Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMZDUXG)

• Drug Name: cinnamaldehyde Drug Info
• Synonyms: cinnamic aldehyde

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 637511
  ChEBI ID: CHEBI:16731
  CAS Number: CAS 104-55-2
  TTD Drug ID: DMZDUXG

Molecule-Related Drug Atlas

Drug(s) Targeting Transient receptor potential cation channel V3 (TRPV3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
SAR292833	DM63QY0	Pain	MG30-MG3Z	Phase 2	[10]
2-APB	DM9AKVR	Discovery agent	N.A.	Investigative	[11]
diphenylboronic anhydride	DMRQZTS	Discovery agent	N.A.	Investigative	[12]
citral	DM53ZGY	Discovery agent	N.A.	Investigative	[13]
aspirin-triggered resolvin D1	DMOP941	Discovery agent	N.A.	Investigative	[14]
carvacrol	DMINM2D	Discovery agent	N.A.	Investigative	[15]
diphenyltetrahydrofuran	DMK8T61	Discovery agent	N.A.	Investigative	[12]
carveol	DMGIZ5U	Discovery agent	N.A.	Investigative	[16]
dihydrocarveol	DMS4U68	Discovery agent	N.A.	Investigative	[16]
tetrahydrocannabivarin	DMDY1MZ	Discovery agent	N.A.	Investigative	[17]

Drug(s) Targeting Transformation-sensitive protein p120 (TRPA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[18]
LY3526318	DMFXNQM	Chronic low-back pain	MG30	Phase 2	[19]
HX-100	DMFRM15	Diabetic neuropathy	8C0Z	Phase 1	[20]
NPPB	DMFIWAN	Discovery agent	N.A.	Investigative	[21]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[22]
[3H]resolvin D1	DMFT0HU	Discovery agent	N.A.	Investigative	[23]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[24]
icilin	DMYVOL9	Discovery agent	N.A.	Investigative	[25]
4-oxo-nonenal	DMPX1J9	Discovery agent	N.A.	Investigative	[26]
dibutyl phthalate	DMEDGKO	Discovery agent	N.A.	Investigative	[27]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[28]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[29]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[30]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[31]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[32]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[33]
Selenium	DM25CGV	N. A.	N. A.	Approved	[34]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[35]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[36]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]

Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[38]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[39]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[40]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[41]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[42]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[43]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[44]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[45]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[47]

Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[48]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[31]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[49]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[41]
Selenium	DM25CGV	N. A.	N. A.	Approved	[50]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[51]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[44]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[45]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[53]

Drug(s) Affected By Glutathione reductase, mitochondrial (GSR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[54]
Ketoprofen	DMRKXPT	Bursitis		Approved	[55]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[56]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[57]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[58]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[59]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[60]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[61]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[62]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[63]

Drug(s) Affected By Lymphotoxin-alpha (LTA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[64]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[65]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[68]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[69]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[70]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[71]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[72]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[72]

Drug(s) Affected By Plasminogen activator inhibitor 1 (SERPINE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[73]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[74]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[75]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[76]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[77]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[60]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[79]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[80]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[81]

Drug(s) Affected By Neutrophil cytosol factor 1 (NCF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[84]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[87]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[88]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[89]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[90]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[91]

Drug(s) Affected By NADPH--cytochrome P450 reductase (POR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
Tacrolimus	DMZ7XNQ	Graft-versus-host disease	4B24	Approved	[93]
Selenium	DM25CGV	N. A.	N. A.	Approved	[50]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[94]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[64]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[95]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]

Drug(s) Affected By Early growth response protein 1 (EGR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[29]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[98]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[99]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[64]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[101]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[103]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[65]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[104]

Drug(s) Affected By Glutathione peroxidase 2 (GPX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[40]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[98]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[58]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[60]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[105]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[106]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[107]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[80]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[108]

Drug(s) Affected By Cytochrome P450 7A1 (CYP7A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[109]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[58]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[99]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[110]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[111]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[64]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[112]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[80]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[113]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[110]

Drug(s) Affected By Caspase-1 (CASP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[114]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[115]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[116]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[117]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[118]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[119]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[120]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[121]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[122]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[123]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[29]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[124]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[49]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[125]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[126]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[98]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[127]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[128]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[129]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[130]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[131]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[132]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[133]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[134]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[98]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[135]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[136]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[137]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[138]

Drug(s) Affected By Flavin-containing monooxygenase 5 (FMO5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[64]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[101]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[139]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[139]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[105]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[105]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[140]

Drug(s) Affected By E3 ubiquitin-protein ligase Mdm2 (MDM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[114]
Flucytosine	DM13VTW	Cryptococcal meningitis		Approved	[141]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[141]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[143]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[144]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[62]
Amifostine	DM5FL14	Mucositis	CA00	Approved	[145]

Drug(s) Affected By Titin (TTN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[147]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[148]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[149]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[150]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[151]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[152]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[153]

Drug(s) Affected By Sulfiredoxin-1 (SRXN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[40]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[154]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[155]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[156]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[157]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[158]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[159]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[38]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[38]

Drug(s) Affected By Kelch-like ECH-associated protein 1 (KEAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[160]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[161]
Selenium	DM25CGV	N. A.	N. A.	Approved	[50]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[120]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[123]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[38]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[38]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[162]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[163]

Drug(s) Affected By Toll-like receptor 4 (TLR4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[164]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[165]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[166]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[167]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[168]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[169]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[170]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[165]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[38]

Drug(s) Affected By Pirin (PIR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[154]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[171]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[172]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[173]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[168]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[38]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[38]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[174]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[175]

Drug(s) Affected By ATP-binding cassette sub-family C member 3 (ABCC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[176]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[177]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[178]
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[109]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[40]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[179]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[154]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[180]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[181]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[182]

Drug(s) Affected By Disintegrin and metalloproteinase domain-containing protein 23 (ADAM23)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[105]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[167]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[184]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[149]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[185]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[186]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 21 (TNFRSF21)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[187]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[155]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[188]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[81]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[189]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[190]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[114]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[32]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[115]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[191]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[41]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[191]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[117]
Selenium	DM25CGV	N. A.	N. A.	Approved	[192]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[193]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[194]

Drug(s) Affected By Ferritin heavy chain (FTH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[40]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[195]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[43]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[99]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[155]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[188]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[196]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[197]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[198]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[38]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[199]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[200]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[201]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[30]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[202]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[32]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[191]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[41]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[203]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[191]

Drug(s) Affected By Glucose-6-phosphate 1-dehydrogenase (G6PD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[204]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[55]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[205]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[206]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[57]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[58]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[171]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[172]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[207]

Drug(s) Affected By Interferon-induced GTP-binding protein Mx1 (MX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[50]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[208]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[188]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[208]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[209]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[95]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[108]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[210]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[211]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[212]

Drug(s) Affected By Liver carboxylesterase 1 (CES1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[213]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[131]
Dextropropoxyphene	DM23HCX	Pain	MG30-MG3Z	Approved	[214]
Selenium	DM25CGV	N. A.	N. A.	Approved	[50]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[215]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[188]
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[216]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[217]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[108]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[218]

Drug(s) Affected By Low affinity immunoglobulin gamma Fc region receptor II-b (FCGR2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[164]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[119]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[70]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[83]
EUGENOL	DM7US1H	Discovery agent	N.A.	Patented	[219]

Drug(s) Affected By Low affinity immunoglobulin gamma Fc region receptor II-c (FCGR2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[188]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[70]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[220]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[221]

Drug(s) Affected By Sodium/calcium exchanger 1 (SLC8A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[222]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[223]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[224]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[225]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[226]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[39]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[149]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[227]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[228]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[153]

Drug(s) Affected By Pro-adrenomedullin (ADM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[131]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[229]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[164]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[167]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[230]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[231]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[28]

Drug(s) Affected By Interferon alpha-inducible protein 27, mitochondrial (IFI27)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[154]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[208]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[188]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[208]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[210]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[232]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[212]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[233]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[66]

Drug(s) Affected By T-lymphocyte activation antigen CD86 (CD86)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[234]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[235]
Kanamycin	DM2DMPO	Bacteremia	1A73	Approved	[236]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[164]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[165]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[188]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[236]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[173]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[236]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[190]

Drug(s) Affected By Excitatory amino acid transporter 2 (SLC1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[237]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[167]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[238]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[239]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[174]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[147]
Thiamphenicol	DMDRKH2	Bacterial infection	1A00-1C4Z	Approved	[240]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[237]

Drug(s) Affected By Adenosine kinase (ADK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[186]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[241]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[210]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[222]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[147]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[184]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[148]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[242]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[243]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[154]

Drug(s) Affected By Phospholipid-transporting ATPase IH (ATP11A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[186]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[187]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[156]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[174]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[244]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[147]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[88]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[224]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[245]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[246]

Drug(s) Affected By Collagen alpha-1(VII) chain (COL7A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[247]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[248]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[155]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[249]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[222]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[250]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[251]

Drug(s) Affected By cAMP-responsive element modulator (CREM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[99]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[65]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[252]
Bortezomib	DMNO38U	Leukemia		Approved	[253]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[254]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[245]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[246]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]

Drug(s) Affected By Aldo-keto reductase family 1 member C1 (AKR1C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[255]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[256]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[257]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[258]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[256]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[256]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[248]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[259]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[258]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[256]

Drug(s) Affected By Serine/arginine-rich splicing factor 11 (SRSF11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[260]
Selenium	DM25CGV	N. A.	N. A.	Approved	[50]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[167]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[222]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[147]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[253]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[252]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[154]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[224]

Drug(s) Affected By Dematin (DMTN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[174]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[262]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[263]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[264]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[265]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[153]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[266]

Drug(s) Affected By Urea transporter 1 (SLC14A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[210]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[267]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[268]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[97]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[269]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[270]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[271]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[270]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[272]

Drug(s) Affected By cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B (PDE3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[188]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[174]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Roflumilast	DMPGHY8	Asthma	CA23	Approved	[273]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[274]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[149]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[275]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[276]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[265]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[153]

Drug(s) Affected By Mothers against decapentaplegic homolog 2 (SMAD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[277]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[278]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[279]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[275]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[280]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[281]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[281]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[147]

Drug(s) Affected By Hereditary hemochromatosis protein (HFE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[108]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[282]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[283]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[147]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[284]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[151]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[285]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[286]
paraquat	DMR8O3X	Discovery agent	N.A.	Investigative	[287]

Drug(s) Affected By Interferon-induced protein 44-like (IFI44L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[208]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[188]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[208]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[108]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[210]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[282]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[212]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[275]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[66]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[184]

Drug(s) Affected By Pleckstrin homology-like domain family A member 2 (PHLDA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[154]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[155]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[288]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[121]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[172]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[275]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[173]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]

Drug(s) Affected By Neuroblastoma breakpoint family member 10 (NBPF10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[186]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[289]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[289]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[290]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[246]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[151]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[275]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[266]

Drug(s) Affected By Protein ABHD12B (ABHD12B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[291]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[149]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[265]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[292]

Drug(s) Affected By Reticulon-4 receptor-like 1 (RTN4RL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[186]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[168]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[293]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[148]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[149]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[262]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[265]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[153]

Drug(s) Affected By Liprin-beta-1 (PPFIBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[50]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[99]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[156]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[294]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[190]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[38]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[38]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[222]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[38]

Drug(s) Affected By Threonine synthase-like 2 (THNSL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[295]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[224]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[97]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[295]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[97]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[296]

Drug(s) Affected By MAP kinase-activated protein kinase 5 (MAPKAPK5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[295]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[297]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[297]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[298]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[299]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[265]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[153]
PMID26560530-Compound-35	DMO36RL	N. A.	N. A.	Patented	[300]

Drug(s) Affected By Anion exchange transporter (SLC26A7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[301]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[246]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[246]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[302]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[152]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[303]

Drug(s) Affected By Delta-sarcoglycan (SGCD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[186]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[167]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[304]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[232]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[305]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[270]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[149]

Drug(s) Affected By ELL-associated factor 2 (EAF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[156]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[306]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[307]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[190]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[222]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[306]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[293]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[308]

Drug(s) Affected By Coiled-coil domain-containing protein 34 (CCDC34)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[260]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[188]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[139]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[139]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[140]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[151]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[309]

Drug(s) Affected By Alsin (ALS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[190]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[222]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[148]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[310]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[88]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[245]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[311]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[265]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[266]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[312]

Drug(s) Affected By Proton myo-inositol cotransporter (SLC2A13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[151]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[309]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[97]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[304]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[313]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[314]

Drug(s) Affected By Pannexin-2 (PANX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[65]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[168]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[231]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[184]
Bortezomib	DMNO38U	Leukemia		Approved	[253]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[204]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[270]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[264]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[265]

Drug(s) Affected By Probable G-protein coupled receptor 21 (GPR21)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[315]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[153]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[292]

Drug(s) Affected By Endothelial PAS domain-containing protein 1 (EPAS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[277]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[164]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[316]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[120]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[275]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[317]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[222]
Ketorolac	DMI4EL5	Postoperative inflammation	1A00-CA43.1	Approved	[317]

Drug(s) Affected By Oxidoreductase HTATIP2 (HTATIP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[154]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[188]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[173]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[210]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[38]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[281]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[212]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[281]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[222]

Drug(s) Affected By PDZ domain-containing protein MAGIX (MAGIX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[99]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[293]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[318]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[265]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[153]

Drug(s) Affected By Dynein light chain roadblock-type 1 (DYNLRB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[260]
Selenium	DM25CGV	N. A.	N. A.	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[174]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[222]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[184]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[204]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[265]

Drug(s) Affected By PR domain zinc finger protein 5 (PRDM5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[222]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[148]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[151]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[265]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[319]

Drug(s) Affected By Double-stranded RNA-binding protein Staufen homolog 2 (STAU2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[186]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[222]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[320]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[265]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[266]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[321]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[319]

Drug(s) Affected By CCR4-NOT transcription complex subunit 2 (CNOT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[154]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[173]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[147]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[312]
Sodium phenylbutyrate	DMXLBCQ	Spinal muscular atrophy	8B61	Approved	[322]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[266]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[323]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[186]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[324]

Drug(s) Affected By LIM and cysteine-rich domains protein 1 (LMCD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[190]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[38]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[38]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[147]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[325]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[326]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[184]

Drug(s) Affected By Cysteine-rich motor neuron 1 protein (CRIM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[167]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[327]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[210]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[231]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[212]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[147]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[184]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[252]

Drug(s) Affected By Rho GTPase-activating protein 23 (ARHGAP23)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[188]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[88]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[224]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
Testosterone undecanoate	DMZO10Y	Hypogonadism	5A61.0	Approved	[328]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[329]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[276]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[330]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[153]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[266]

Drug(s) Affected By B-cell receptor-associated protein 29 (BCAP29)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[260]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[331]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[156]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[172]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[139]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[148]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[150]

Drug(s) Affected By Integrin alpha-11 (ITGA11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[74]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[232]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[326]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[251]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[305]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[149]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[151]

Drug(s) Affected By Suppressor of fused homolog (SUFU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[266]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[168]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[148]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[318]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[332]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[333]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
Vismodegib	DM5IXKQ	Basal cell carcinoma	2C32	Approved	[334]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[262]
LDE225	DMM9F25	Basal cell carcinoma	2C32	Phase 2	[334]

Drug(s) Affected By Ninein-like protein (NINL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[164]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[148]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[312]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[50]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[265]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[312]

Drug(s) Affected By Sorting nexin-24 (SNX24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[222]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[226]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[275]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[97]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[312]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[292]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[314]

Drug(s) Affected By Low-density lipoprotein receptor-related protein 12 (LRP12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[275]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[168]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[148]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[88]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[226]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[262]

Drug(s) Affected By LHFPL tetraspan subfamily member 6 protein (LHFPL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[188]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[172]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[275]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[84]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[335]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[267]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[243]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[204]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[336]

Drug(s) Affected By Serine/threonine-protein kinase 24 (STK24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[50]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[65]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[147]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[184]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[311]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[337]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[262]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[330]

Drug(s) Affected By Interleukin-7 receptor subunit alpha (IL7R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[338]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[95]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[198]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[210]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[190]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[282]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[66]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[184]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[339]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[340]

Drug(s) Affected By Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[29]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[161]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[341]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[342]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[343]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[344]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[101]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[289]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[62]

Drug(s) Affected By Neurogenic locus notch homolog protein 3 (NOTCH3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[50]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[168]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[339]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[345]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[267]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[184]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Tetracycline	DMZA017	Acne vulgaris	ED80	Approved	[346]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[264]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[265]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[347]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[49]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[179]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[348]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[173]
Selenium	DM25CGV	N. A.	N. A.	Approved	[349]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[350]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[351]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[352]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[164]

Drug(s) Affected By Ferritin light chain (FTL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[40]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[98]
Selenium	DM25CGV	N. A.	N. A.	Approved	[50]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[195]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[120]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[65]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[353]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[222]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[147]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[354]

Drug(s) Affected By Troponin T, cardiac muscle (TNNT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[355]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[156]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[356]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[148]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[224]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
Tacrolimus	DMZ7XNQ	Graft-versus-host disease	4B24	Approved	[357]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[358]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[149]

Drug(s) Affected By AMP deaminase 3 (AMPD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[50]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[188]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[232]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[148]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[245]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[151]

Drug(s) Affected By Sequestosome-1 (SQSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[359]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[360]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[361]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[277]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[362]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[331]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[155]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[120]

Drug(s) Affected By Protein sel-1 homolog 3 (SEL1L3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[167]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[304]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[212]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[363]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[184]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[251]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[140]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[88]

Drug(s) Affected By Nesprin-2 (SYNE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[266]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[222]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[147]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[245]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[151]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[315]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[265]

Drug(s) Affected By Aldo-keto reductase family 1 member C2 (AKR1C2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[256]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[257]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[98]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[364]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[256]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[365]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[256]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[366]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[210]

Drug(s) Affected By Aldo-keto reductase family 1 member B10 (AKR1B10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[161]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[58]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[105]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[367]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[157]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[108]
Reserpine	DM6VM38	Hypertension	BA00-BA04	Approved	[368]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[231]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[353]

Drug(s) Affected By C-X-C motif chemokine 14 (CXCL14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[167]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[275]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[304]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[190]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[267]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[369]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[370]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Indomethacin	DMSC4A7	Bursitis		Approved	[291]

Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[371]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[372]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[373]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[374]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[375]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[64]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[258]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[104]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[376]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[377]

Drug(s) Affected By Intercellular adhesion molecule 1 (ICAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[378]
Dicloxacillin	DM8EU0Z	Bacterial infection	1A00-1C4Z	Approved	[378]
Ergonovine	DM0VEC1	Postpartum haemorrhage	JA43	Approved	[55]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[379]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[380]
Mizolastine	DM1FDN8	Allergic rhinitis	CA08.0	Approved	[381]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[382]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[383]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[118]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[35]

Drug(s) Affected By Stromelysin-1 (MMP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[55]
Fluvastatin	DM4MDJY	Arteriosclerosis	BD40	Approved	[55]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[55]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[55]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[114]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[74]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[384]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[385]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[386]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[387]

Drug(s) Affected By Growth-regulated alpha protein (CXCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[388]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[74]
Selenium	DM25CGV	N. A.	N. A.	Approved	[192]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[99]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[47]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[155]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[171]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[208]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[171]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[389]

Drug(s) Affected By C-C motif chemokine 4 (CCL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[64]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[101]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[390]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[198]
Betamethasone	DMAHJEF	Acute adrenal insufficiency		Approved	[391]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[231]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[391]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[66]

Drug(s) Affected By Fatty acid-binding protein, adipocyte (FABP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[47]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[392]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[393]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[394]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[47]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[395]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[396]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[397]

Drug(s) Affected By C-X-C chemokine receptor type 1 (CXCR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[398]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[399]
Teriflunomide	DMQ2FKJ	Hyperlipidaemia	5C80	Approved	[400]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[401]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[402]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[403]
PBI-05204	DM05WIU	Pancreatic cancer	2C10	Phase 2	[404]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[50]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[405]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[406]

Drug(s) Affected By Dual specificity protein phosphatase 1 (DUSP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[388]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[49]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[33]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[407]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[408]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[409]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[410]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[411]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[168]

Drug(s) Affected By Serpin B3 (SERPINB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[119]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[409]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[412]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[211]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[314]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[267]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[6]
Seocalcitol	DMKL9QO	Rickets	5B57	Phase 3	[412]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[265]
EUGENOL	DM7US1H	Discovery agent	N.A.	Patented	[6]

Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[413]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[414]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[415]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[416]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[417]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[418]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[419]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[206]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[191]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[420]

Drug(s) Affected By C-C motif chemokine 20 (CCL20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[388]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[32]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[74]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[208]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[155]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[421]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[208]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[190]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[169]

Drug(s) Affected By Pro-interleukin-16 (IL16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[164]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[188]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[422]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[232]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[423]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[424]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[6]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[268]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[68]

Drug(s) Affected By Interleukin-18 (IL18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[114]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[425]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[164]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[426]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[123]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[427]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[231]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[281]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[428]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[281]

Drug(s) Affected By Insulin-induced gene 1 protein (INSIG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[277]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[429]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[105]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[120]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[430]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[172]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[120]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[95]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[139]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[38]

Drug(s) Affected By Transforming growth factor beta-1-induced transcript 1 protein (TGFB1I1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[161]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[171]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[171]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[275]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[431]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[147]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[432]

Drug(s) Affected By Serine protease HTRA2, mitochondrial (HTRA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[48]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[343]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[188]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[249]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[139]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[222]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[147]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[433]
Bortezomib	DMNO38U	Leukemia		Approved	[434]

Drug(s) Affected By Tripartite motif-containing protein 16 (TRIM16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[188]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[327]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[190]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[212]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[147]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[175]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[267]
Penicillin V	DMKVOYF	Acute otitis media	AB00	Approved	[175]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[435]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[436]

Drug(s) Affected By Hypoxanthine-guanine phosphoribosyltransferase (HPRT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Thioguanine	DM7NKEV	Acute lymphocytic leukaemia	2B33.3	Approved	[437]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[438]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[439]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[164]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[64]
Fructose	DM43AN2	Vomiting	MD90	Approved	[440]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[167]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[441]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[139]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[139]

Drug(s) Affected By Protein c-Fos (FOS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[65]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[131]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[442]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[49]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[442]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[179]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[425]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[443]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[444]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[445]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[446]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[447]
Fructose	DM43AN2	Vomiting	MD90	Approved	[55]
Ketoprofen	DMRKXPT	Bursitis		Approved	[55]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[448]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[449]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[450]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[451]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[452]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[453]

Drug(s) Affected By Interleukin-1 alpha (IL1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[388]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[191]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[191]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[453]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[191]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[164]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[454]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[191]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[64]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[188]

Drug(s) Affected By Prelamin-A/C (LMNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[50]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[455]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[456]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[457]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[168]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[218]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[147]

Drug(s) Affected By Albumin (ALB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[245]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[55]
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[458]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[459]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[460]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[461]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[462]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[463]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[464]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[465]

Drug(s) Affected By Platelet basic protein (PPBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[466]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[467]
Nortriptyline	DM4KDYJ	Depression	6A70-6A7Z	Approved	[468]
Paroxetine	DM5PVQE	Anxiety disorder	6B00-6B0Z	Approved	[468]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[469]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[29]
Amlodipine	DMBDAZV	Angina pectoris	BA40	Approved	[470]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[267]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[471]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[472]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[164]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[144]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[473]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[474]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[475]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[476]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[477]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[478]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[479]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[480]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[90]
Fructose	DM43AN2	Vomiting	MD90	Approved	[55]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[481]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[202]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[49]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[132]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[187]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[482]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[483]

Drug(s) Affected By Heat shock protein HSP 90-alpha (HSP90AA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[484]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[114]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[206]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[115]
Selenium	DM25CGV	N. A.	N. A.	Approved	[50]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[485]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[146]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[388]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[486]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[487]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[341]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[488]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[137]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[488]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[489]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[490]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[491]

Drug(s) Affected By Heat shock 70 kDa protein 1A (HSPA1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[492]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[29]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[49]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[115]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[98]
Selenium	DM25CGV	N. A.	N. A.	Approved	[50]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[493]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[164]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[64]

Drug(s) Affected By C-C motif chemokine 3 (CCL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[494]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[164]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[64]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[101]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[495]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[469]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[390]
Betamethasone	DMAHJEF	Acute adrenal insufficiency		Approved	[391]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[391]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[494]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[496]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[497]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[498]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[499]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[55]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[388]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[500]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[501]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[449]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[502]

Drug(s) Affected By Heat shock cognate 71 kDa protein (HSPA8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[503]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[49]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[504]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[260]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[493]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[456]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[495]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[209]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[104]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[505]

Drug(s) Affected By Cytochrome P450 2A6 (CYP2A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tegafur	DM31ZQM	Solid tumour/cancer	2A00-2F9Z	Approved	[506]
Methoxsalen	DME8FZ9	Cutaneous T-cell lymphoma	2B01	Approved	[507]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[508]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[509]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[510]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[511]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[512]
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[513]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[514]

Drug(s) Affected By C-C motif chemokine 5 (CCL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[132]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[515]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[235]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[164]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[516]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[155]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[517]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[390]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[518]

Drug(s) Affected By Pyruvate kinase PKM (PKM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[277]
Selenium	DM25CGV	N. A.	N. A.	Approved	[50]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[519]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[120]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[275]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[520]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[521]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[218]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[162]

Drug(s) Affected By Cyclic AMP-responsive element-binding protein 1 (CREB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[522]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[523]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[187]
Selenium	DM25CGV	N. A.	N. A.	Approved	[50]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[338]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[524]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[525]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[525]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[526]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[527]

Drug(s) Affected By Heat shock 70 kDa protein 6 (HSPA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[29]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[49]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[98]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[146]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[155]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[101]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[156]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[528]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[104]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]

Drug(s) Affected By Transcription factor JunD (JUND)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[202]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[49]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[425]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[331]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[529]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[62]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[80]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[173]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[530]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-3 (ATF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[29]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[98]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[331]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[306]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[248]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[531]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[105]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[188]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[62]

Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[28]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[530]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[49]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[532]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[425]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[533]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[534]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[535]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[536]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[454]

Drug(s) Affected By Fibroblast growth factor receptor 2 (FGFR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[247]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[154]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[537]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[173]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[538]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[538]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[139]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[139]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[231]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[244]

Drug(s) Affected By CCN family member 2 (CCN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[388]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[206]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[74]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[105]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[288]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[208]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[539]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[108]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[29]

Drug(s) Affected By M-phase inducer phosphatase 2 (CDC25B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[540]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[260]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[541]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[188]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[542]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[139]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[139]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[543]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[544]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[545]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[477]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[502]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[546]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[547]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[548]
Selenium	DM25CGV	N. A.	N. A.	Approved	[50]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[461]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[350]

Drug(s) Affected By Glutaredoxin-1 (GLRX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[98]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[108]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[147]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[184]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[140]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[252]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[148]

Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 2 (MAP2K2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[549]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[550]
Selenium	DM25CGV	N. A.	N. A.	Approved	[50]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[266]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[551]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[552]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[95]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[553]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[147]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[554]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[555]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[556]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[474]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[557]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[558]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[559]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[560]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[561]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[562]

Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[563]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[481]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[451]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[33]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[482]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[454]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[564]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[565]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[482]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[566]

Drug(s) Affected By Crk-like protein (CRKL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nilotinib	DM7HXWT	Chronic myelogenous leukaemia	2A20.0	Approved	[567]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[568]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[147]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[569]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[570]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[312]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
Rigosertib	DMOSTXF	Myelodysplastic syndrome	2A37	Phase 3	[571]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[572]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[330]

Drug(s) Affected By Glutamate--cysteine ligase catalytic subunit (GCLC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[40]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[33]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[573]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[58]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[181]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[574]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[155]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[188]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[575]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[576]

Drug(s) Affected By Glutamate--cysteine ligase regulatory subunit (GCLM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[40]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[187]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[58]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[577]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[188]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[172]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[62]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[578]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[327]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[579]

Drug(s) Affected By Dual specificity protein kinase CLK2 (CLK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[580]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[174]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[148]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[581]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[265]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[266]
T83193	DMHO29Y	Discovery agent	N.A.	Patented	[582]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[583]

Drug(s) Affected By BH3-interacting domain death agonist (BID)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[114]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[341]
Selenium	DM25CGV	N. A.	N. A.	Approved	[584]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[454]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[60]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[156]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[585]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[586]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[526]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]

Drug(s) Affected By Actin, cytoplasmic 1 (ACTB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[425]
Selenium	DM25CGV	N. A.	N. A.	Approved	[50]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[493]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[188]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[587]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[65]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]

Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein K (HNRNPK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[266]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[588]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[589]
Haloperidol	DM96SE0	Delirium		Approved	[205]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[162]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[147]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[543]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[590]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[589]

Drug(s) Affected By Histone H4 (H4C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[388]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[98]
Selenium	DM25CGV	N. A.	N. A.	Approved	[50]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[331]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[99]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[155]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[188]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[591]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[249]

Drug(s) Affected By Hemoglobin subunit beta (HBB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[277]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[592]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[65]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[593]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Voxelotor	DMCS6M5	Sickle-cell disorder	3A51	Approved	[594]
Ibrutinib	DMHZCPO	Mantle cell lymphoma	2A85.5	Approved	[595]
Flucloxacillin	DMNUWST	Bacterial infection	1A00-1C4Z	Approved	[596]
Capecitabine	DMTS85L	Adenocarcinoma	2D40	Approved	[597]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[598]

Drug(s) Affected By Cytochrome c (CYCS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[114]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[599]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[486]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[600]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[601]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[602]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[164]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[603]
Pefloxacin	DM49IGF	Gonococcal urethritis	1A70.0Y	Approved	[604]

Drug(s) Affected By CD83 antigen (CD83)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[605]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[165]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[155]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[188]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[198]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[606]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[607]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[174]

Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[114]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[502]
Selenium	DM25CGV	N. A.	N. A.	Approved	[50]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[608]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[536]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[455]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[609]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[610]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[496]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[562]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[388]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[500]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[611]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[600]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[134]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[425]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[612]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[137]

Drug(s) Affected By Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[449]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[611]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[613]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[605]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[614]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[615]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[101]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[611]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[616]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[617]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 3 (BIRC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[618]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[562]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[186]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[341]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[60]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[156]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[159]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[619]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[620]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 2 (BIRC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[618]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[562]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[621]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[622]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[623]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[539]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[624]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[620]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[625]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[626]

Drug(s) Affected By Eukaryotic translation initiation factor 3 subunit A (EIF3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[154]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[627]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[174]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[147]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[148]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[628]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[54]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[204]

Drug(s) Affected By Frizzled-2 (FZD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[154]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[629]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[167]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[275]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[108]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[168]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[222]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[630]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[184]

Drug(s) Affected By Caspase-8 (CASP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[631]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[632]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[633]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[114]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[634]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[635]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[341]
Selenium	DM25CGV	N. A.	N. A.	Approved	[50]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[636]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[164]

Drug(s) Affected By Dual specificity protein phosphatase 6 (DUSP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[388]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[154]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[60]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[108]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[553]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[174]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[222]

Drug(s) Affected By Nucleotide sugar transporter SLC35D2 (SLC35D2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[637]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[148]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[245]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[151]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[295]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[221]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[638]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[153]

Drug(s) Affected By Heat shock protein 105 kDa (HSPH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[64]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[159]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[62]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[81]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[411]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[231]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[222]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[147]

Drug(s) Affected By MAP/microtubule affinity-regulating kinase 4 (MARK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[186]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[188]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[163]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[204]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[262]
Rigosertib	DMOSTXF	Myelodysplastic syndrome	2A37	Phase 3	[639]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[640]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[265]

Drug(s) Affected By Serine/threonine-protein phosphatase 1 regulatory subunit 10 (PPP1R10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[388]
Selenium	DM25CGV	N. A.	N. A.	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[174]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[147]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[369]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[148]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[88]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[224]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[245]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]

Drug(s) Affected By Diablo IAP-binding mitochondrial protein (DIABLO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[48]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[260]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[341]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[343]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[615]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[641]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[586]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[168]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[295]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[147]

Drug(s) Affected By DNA damage-inducible transcript 4 protein (DDIT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[29]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[277]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[138]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[629]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[642]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[167]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[62]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[249]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[643]

Drug(s) Affected By Programmed cell death 1 ligand 1 (CD274)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[644]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[188]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[645]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[331]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[646]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[139]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[190]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[647]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]

Drug(s) Affected By DNA (DNMT3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[648]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[649]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[650]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[139]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[139]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[295]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[651]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[356]

Drug(s) Affected By DnaJ homolog subfamily B member 4 (DNAJB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[29]
Selenium	DM25CGV	N. A.	N. A.	Approved	[50]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[64]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[159]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[62]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[173]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[579]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[411]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[29]

Drug(s) Affected By C-type lectin domain family 4 member A (CLEC4A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[188]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[652]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[305]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[265]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[153]
EUGENOL	DM7US1H	Discovery agent	N.A.	Patented	[653]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[313]

Drug(s) Affected By Cystine/glutamate transporter (SLC7A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[40]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[191]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[187]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[191]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[191]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[208]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[654]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[159]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[191]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Transformation-sensitive protein p120 (TRPA1)	TTELV3W	TRPA1_HUMAN	Activator	[2]
Transient receptor potential cation channel V3 (TRPV3)	TT946IA	TRPV3_HUMAN	Activator	[3]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Actin, cytoplasmic 1 (ACTB)	OT1MCP2F	ACTB_HUMAN	Biochemical Pathways	[4]
Adenosine kinase (ADK)	OTXR6VDI	ADK_HUMAN	Gene/Protein Processing	[5]
Albumin (ALB)	OTVMM513	ALBU_HUMAN	Biochemical Pathways	[4]
Aldo-keto reductase family 1 member B10 (AKR1B10)	OTOA4HTH	AK1BA_HUMAN	Gene/Protein Processing	[6]
Aldo-keto reductase family 1 member C1 (AKR1C1)	OTQKR4CM	AK1C1_HUMAN	Gene/Protein Processing	[5]
Aldo-keto reductase family 1 member C2 (AKR1C2)	OTQ2XMO3	AK1C2_HUMAN	Gene/Protein Processing	[7]
Alsin (ALS2)	OT8BAM04	ALS2_HUMAN	Gene/Protein Processing	[5]
AMP deaminase 3 (AMPD3)	OT5SP1KJ	AMPD3_HUMAN	Gene/Protein Processing	[8]
Anion exchange transporter (SLC26A7)	OTZ4ZMHV	S26A7_HUMAN	Gene/Protein Processing	[5]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Gene/Protein Processing	[9]

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