Details of Disease

General Information of Disease (ID: DISBUOMJ)

Disease Name Chronic pancreatitis
Synonyms pancreatitis, chronic
Definition A chronic inflammatory process causing damage and fibrosis of the pancreatic parenchyma. Signs and symptoms include abdominal pain, malabsorption and diabetes mellitus.
Disease Hierarchy
DIS0IJEF: Pancreatitis
DISBUOMJ: Chronic pancreatitis
Disease Identifiers
MONDO ID
MONDO_0005003
MESH ID
D050500
UMLS CUI
C0149521
MedGen ID
101753
HPO ID
HP:0006280
SNOMED CT ID
235494005

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 28 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
CASR TTBUYHA Limited Biomarker [1]
IL1RAP TTWS50K Limited Altered Expression [2]
IL1RL2 TTUS18T Limited Altered Expression [2]
NNT TTKIH76 Limited Biomarker [3]
PNPLA3 TTEUAEH Limited Genetic Variation [4]
PPP5C TTTW7FJ Limited Biomarker [5]
PPT1 TTSQC14 Limited Biomarker [5]
PSCA TT9T4AV Limited Altered Expression [6]
REG4 TTVZEHU Limited Altered Expression [7]
SCT TTOBVIN Limited Biomarker [8]
SLC5A7 TTRV7W3 Limited Biomarker [9]
TACR2 TTYO0A3 Limited Biomarker [5]
TACR3 TTBPGLU Limited Altered Expression [5]
TK1 TTP3QRF Limited Altered Expression [10]
ATF4 TTQCKWT moderate Biomarker [11]
CPA1 TT3LJ6G moderate Biomarker [12]
ENPEP TT9PBIL moderate Biomarker [13]
REG3A TTL4H8N moderate Biomarker [14]
TFF1 TTNOJIZ moderate Biomarker [15]
ANXA10 TT0NL6U Strong Altered Expression [16]
CFTR TTRLZHP Strong Genetic Variation [17]
CTDSP1 TTHZAF0 Strong Altered Expression [18]
CTRC TT3RMNA Strong Biomarker [19]
LPL TTOF3WZ Strong Genetic Variation [20]
NGF TTDN3LF Strong Altered Expression [21]
NPTX2 TTNJ5A6 Strong Posttranslational Modification [22]
PDX1 TT8SGZK Strong Biomarker [23]
ST8SIA4 TTDP8YM Strong Biomarker [24]
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⏷ Show the Full List of 28 DTT(s)
This Disease Is Related to 1 DTP Molecule(s)
Gene Name DTP ID Evidence Level Mode of Inheritance REF
SLC26A6 DTVGOLN Limited Biomarker [25]
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This Disease Is Related to 7 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
ADH1B DEEN9RD Limited Genetic Variation [26]
UGT1A6 DESD26P Limited Genetic Variation [27]
UGT1A7 DEZO4N3 Limited Genetic Variation [28]
UGT1A8 DE2GB8N Limited Genetic Variation [27]
ADH1C DEM1HNL Strong Biomarker [29]
ADH5 DEIOH6A Strong Biomarker [29]
AKR1A1 DED2FW3 Strong Genetic Variation [30]
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⏷ Show the Full List of 7 DME(s)
This Disease Is Related to 61 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
AIP OTDJ3OSV Limited Biomarker [31]
ANAPC13 OTQWXHEJ Limited Biomarker [32]
APOC2 OTLINYIQ Limited Genetic Variation [33]
BHLHA15 OTY7IER8 Limited Biomarker [34]
CCL8 OTCTWYN8 Limited Biomarker [3]
CELA3A OT9JAL80 Limited Biomarker [35]
CELA3B OTGU8BE9 Limited Biomarker [36]
CEMP1 OTUEH5X5 Limited Biomarker [37]
COL11A1 OTB0DRMS Limited Altered Expression [38]
CRISP3 OTBSWMPL Limited Altered Expression [39]
CTRB1 OTFFF738 Limited Genetic Variation [40]
CTRB2 OTR9TOBV Limited Genetic Variation [41]
CTRL OTB6NA5O Limited Biomarker [35]
FGF5 OTQXGHBY Limited Altered Expression [42]
GPC1 OTQKRSSV Limited Altered Expression [43]
GPIHBP1 OTDF8R2M Limited Genetic Variation [44]
HAP1 OT6SG0JQ Limited Genetic Variation [45]
HEY2 OTU4J3ZI Limited Altered Expression [46]
IL36A OTHBEL5H Limited Biomarker [2]
MARVELD2 OTKB96L5 Limited Biomarker [47]
NFYA OTWFFOVH Limited Genetic Variation [45]
PNLIPRP2 OTJG6BA7 Limited Biomarker [48]
RB1CC1 OTZK8PFX Limited Biomarker [49]
REG3G OTLIUY8Z Limited Biomarker [50]
RIPPLY1 OT19XBFD Limited Genetic Variation [51]
SMAD5 OTQNSVCQ Limited Biomarker [52]
SPOP OTP0107S Limited Biomarker [53]
STX12 OT5IBQ62 Limited Biomarker [52]
TFF2 OTRXB19X Limited Biomarker [15]
TGFB1I1 OTIK337D Limited Altered Expression [54]
TNFRSF10C OTVHOL9B Limited Biomarker [55]
TNFRSF10D OTOSRDJT Limited Biomarker [55]
TPST2 OT2XKFCE Limited Genetic Variation [56]
FMOD OT9EJ5H8 Disputed Altered Expression [57]
ATF6 OTAFHAVI moderate Altered Expression [58]
BAD OT63ERYM moderate ModifyingMutation [59]
COL1A1 OTI31178 moderate Therapeutic [60]
CYGB OTX153DQ moderate Biomarker [61]
LGALS3BP OT9AGQKH moderate Altered Expression [62]
NOX1 OTZPJQCC moderate Biomarker [63]
PDHX OTG7O271 moderate Biomarker [23]
RASSF6 OT25GVWY moderate Altered Expression [64]
CCL1 OT23NON8 Strong Genetic Variation [65]
CLDN2 OTRF3D6Y Strong Genetic Variation [66]
DEFA1 OT5N1B9B Strong Altered Expression [67]
DPYSL3 OTINJV20 Strong Biomarker [68]
FXYD3 OT9PPRHE Strong Biomarker [69]
KRT8 OTTM4X11 Strong Genetic Variation [70]
MORC4 OTJBEHNE Strong Genetic Variation [71]
MSX2 OT1WDKE1 Strong Altered Expression [72]
MUC7 OTSTMP0X Strong Altered Expression [73]
PRDM14 OTWZKY4L Strong Biomarker [74]
PRSS3 OTN3S5YB Strong Genetic Variation [75]
PTHLH OTI1JF13 Strong Biomarker [76]
REG1A OTMHUH1D Strong Biomarker [77]
SCPEP1 OT43LYEZ Strong Altered Expression [18]
SPARCL1 OT74DWMV Strong Biomarker [78]
SPINK7 OTK3VOI3 Strong Genetic Variation [65]
SYCP1 OTWFV4KA Strong Altered Expression [18]
TIGAR OTR7NMRJ Strong Genetic Variation [79]
GP2 OTB6TMGY Definitive Biomarker [80]
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⏷ Show the Full List of 61 DOT(s)

References

1 The vitamin D system is deregulated in pancreatic diseases.J Steroid Biochem Mol Biol. 2014 Oct;144 Pt B:402-9. doi: 10.1016/j.jsbmb.2014.07.011. Epub 2014 Jul 30.
2 Interleukin-36 Induces Inflammatory Mediators From Human Pancreatic Myofibroblasts Via a MyD88 Dependent Pathway.Pancreas. 2017 Apr;46(4):539-548. doi: 10.1097/MPA.0000000000000765.
3 Differences in the degree of cerulein-induced chronic pancreatitis in C57BL/6 mouse substrains lead to new insights in identification of potential risk factors in the development of chronic pancreatitis.Am J Pathol. 2013 Sep;183(3):692-708. doi: 10.1016/j.ajpath.2013.05.020. Epub 2013 Jul 8.
4 A common variant of PNPLA3 (p.I148M) is not associated with alcoholic chronic pancreatitis.PLoS One. 2012;7(1):e29433. doi: 10.1371/journal.pone.0029433. Epub 2012 Jan 20.
5 Neurokinin-2 receptor levels correlate with intensity, frequency, and duration of pain in chronic pancreatitis.Ann Surg. 2007 Nov;246(5):786-93. doi: 10.1097/SLA.0b013e318070d56e.
6 Prostate stem cell antigen is a putative target for immunotherapy in pancreatic cancer.Pancreas. 2005 Aug;31(2):119-25. doi: 10.1097/01.mpa.0000173459.81193.4d.
7 Prognostic and diagnostic value of REG4 serum and tissue expression in pancreatic ductal adenocarcinoma.Tumour Biol. 2018 Mar;40(3):1010428318761494. doi: 10.1177/1010428318761494.
8 Jejunal response to secretin is independent of the pancreatic response in secretin-enhanced magnetic resonance cholangiopancreatography.Eur J Radiol. 2019 Mar;112:7-13. doi: 10.1016/j.ejrad.2018.12.024. Epub 2019 Jan 3.
9 Inhibition of the high affinity choline transporter enhances hyperalgesia in a rat model of chronic pancreatitis.Biochem Biophys Res Commun. 2017 Jun 17;488(1):204-210. doi: 10.1016/j.bbrc.2017.05.036. Epub 2017 May 5.
10 Evaluation of pyrimidine metabolising enzymes and in vitro uptake of 3'-[(18)F]fluoro-3'-deoxythymidine ([(18)F]FLT) in pancreatic cancer cell lines.Eur J Nucl Med Mol Imaging. 2002 Sep;29(9):1174-81. doi: 10.1007/s00259-002-0851-0. Epub 2002 Jun 4.
11 Discovery and Functional Annotation of PRSS1 Promoter Variants in Chronic Pancreatitis.Hum Mutat. 2016 Nov;37(11):1149-1152. doi: 10.1002/humu.23053. Epub 2016 Aug 21.
12 Genetic risk in chronic pancreatitis: the misfolding-dependent pathway.Curr Opin Gastroenterol. 2017 Sep;33(5):390-395. doi: 10.1097/MOG.0000000000000380.
13 International consensus statements on early chronic Pancreatitis. Recommendations from the working group for the international consensus guidelines for chronic pancreatitis in collaboration with The International Association of Pancreatology, American Pancreatic Association, Japan Pancreas Society, PancreasFest Working Group and European Pancreatic Club.Pancreatology. 2018 Jul;18(5):516-527. doi: 10.1016/j.pan.2018.05.008. Epub 2018 May 21.
14 Secretory apparatus assessed by analysis of pancreatic secretory stress protein expression in a rat model of chronic pancreatitis.Cell Tissue Res. 2003 Jun;312(3):291-9. doi: 10.1007/s00441-003-0733-1. Epub 2003 May 23.
15 Trefoil factor(s) and CA19.9: A promising panel for early detection of pancreatic cancer.EBioMedicine. 2019 Apr;42:375-385. doi: 10.1016/j.ebiom.2019.03.056. Epub 2019 Apr 5.
16 Annexin A10 is a candidate marker associated with the progression of pancreatic precursor lesions to adenocarcinoma.PLoS One. 2017 Apr 3;12(4):e0175039. doi: 10.1371/journal.pone.0175039. eCollection 2017.
17 Genetic variants in acute, acute recurrent and chronic pancreatitis affect the progression of disease in children.Pancreatology. 2019 Jun;19(4):535-540. doi: 10.1016/j.pan.2019.05.001. Epub 2019 May 7.
18 Expression of cancer testis antigens in pancreatic carcinoma cell lines, pancreatic adenocarcinoma and chronic pancreatitis.Int J Cancer. 2004 Apr 20;109(4):568-75. doi: 10.1002/ijc.20006.
19 SPINK1, PRSS1, CTRC, and CFTR Genotypes Influence Disease Onset and Clinical Outcomes in Chronic Pancreatitis. Clin Transl Gastroenterol. 2018 Nov 12;9(11):204. doi: 10.1038/s41424-018-0069-5.
20 Molecular and functional characterization of familial chylomicronemia syndrome.Atherosclerosis. 2018 Feb;269:272-278. doi: 10.1016/j.atherosclerosis.2017.11.006. Epub 2017 Nov 14.
21 Morphological and immunohistochemical comparison of intrapancreatic nerves between chronic pancreatitis and type 1 autoimmune pancreatitis.Pancreatology. 2017 May-Jun;17(3):403-410. doi: 10.1016/j.pan.2017.02.009. Epub 2017 Feb 20.
22 NPTX2 hypermethylation in pure pancreatic juice predicts pancreatic neoplasms.Am J Med Sci. 2013 Sep;346(3):175-80. doi: 10.1097/MAJ.0b013e31827b94b6.
23 Interferon- Decreases Nuclear Localization of Pdx-1 and Triggers -Cell Dysfunction in Chronic Pancreatitis.J Interferon Cytokine Res. 2015 Jul;35(7):523-9. doi: 10.1089/jir.2014.0082. Epub 2015 Apr 3.
24 Idiopathic pancreatitis related to CFTR: complex inheritance and identification of a modifier gene.J Investig Med. 2002 Sep;50(5):247S-255S. doi: 10.1136/jim-50-suppl5-01.
25 Genetic analysis of the bicarbonate secreting anion exchanger SLC26A6 in chronic pancreatitis.Pancreatology. 2015 Sep-Oct;15(5):508-513. doi: 10.1016/j.pan.2015.08.008. Epub 2015 Sep 1.
26 SPINK1, ADH2, and ALDH2 gene variants and alcoholic chronic pancreatitis in Japan.J Gastroenterol Hepatol. 2008 Mar;23 Suppl 1:S82-6. doi: 10.1111/j.1440-1746.2007.05291.x.
27 Functional polymorphisms of UDP-glucuronosyltransferases 1A1, 1A6 and 1A8 are not involved in chronic pancreatitis.Pharmacogenetics. 2004 Jun;14(6):351-7. doi: 10.1097/00008571-200406000-00004.
28 UGT1A7 polymorphisms in chronic pancreatitis: an example of genotyping pitfalls.Pharmacogenomics J. 2008 Feb;8(1):34-41. doi: 10.1038/sj.tpj.6500443. Epub 2007 Feb 27.
29 The Alcohol Dehydrogenase Isoenzyme as a Potential Marker of Pancreatitis.Anticancer Res. 2018 May;38(5):3019-3024. doi: 10.21873/anticanres.12556.
30 Genetic polymorphisms in alcohol dehydrogenase, aldehyde dehydrogenase and alcoholic chronic pancreatitis susceptibility: a meta-analysis.Gastroenterol Hepatol. 2015 Aug-Sep;38(7):417-25. doi: 10.1016/j.gastrohep.2014.11.009. Epub 2014 Dec 23.
31 The Propagation Display Method Improves the Reproducibility of Pancreatic Shear Wave Elastography.Ultrasound Med Biol. 2019 Aug;45(8):2242-2247. doi: 10.1016/j.ultrasmedbio.2019.04.003. Epub 2019 May 16.
32 Identifying miRNA-mRNA regulation network of chronic pancreatitis based on the significant functional expression.Medicine (Baltimore). 2017 May;96(21):e6668. doi: 10.1097/MD.0000000000006668.
33 A Novel APOC2 Missense Mutation Causing Apolipoprotein C-II Deficiency With Severe Triglyceridemia and Pancreatitis.J Clin Endocrinol Metab. 2017 May 1;102(5):1454-1457. doi: 10.1210/jc.2016-3903.
34 Activation of protein kinase C leads to increased pancreatic acinar cell dedifferentiation in the absence of MIST1.J Pathol. 2012 Nov;228(3):351-65. doi: 10.1002/path.4015. Epub 2012 May 2.
35 Genetic Analysis of Human Chymotrypsin-Like Elastases 3A and 3B (CELA3A and CELA3B) to Assess the Role of Complex Formation between Proelastases and Procarboxypeptidases in Chronic Pancreatitis.Int J Mol Sci. 2016 Dec 20;17(12):2148. doi: 10.3390/ijms17122148.
36 Incomplete functional and morphological recovery after acute and acute recurrent pancreatitis in children.J Gastroenterol Hepatol. 2019 Jan;34(1):293-301. doi: 10.1111/jgh.14288. Epub 2018 Jun 28.
37 Tumor angiogenesis in chronic pancreatitis and pancreatic adenocarcinoma: impact of K-ras mutations.Pancreas. 2000 Apr;20(3):248-55. doi: 10.1097/00006676-200004000-00005.
38 Gene Expression of Col11A1 Is a Marker Not only for Pancreas Carcinoma But also for Adenocarcinoma of the Papilla of Vater, Discriminating Between Carcinoma and Chronic Pancreatitis.Anticancer Res. 2015 Nov;35(11):6153-8.
39 Preferential expression of cystein-rich secretory protein-3 (CRISP-3) in chronic pancreatitis.Histol Histopathol. 2003 Apr;18(2):425-33. doi: 10.14670/HH-18.425.
40 Genome-wide association study identifies inversion in the CTRB1-CTRB2 locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis.Gut. 2018 Oct;67(10):1855-1863. doi: 10.1136/gutjnl-2017-314454. Epub 2017 Jul 28.
41 Chronic pancreatitis: an update on genetic risk factors.Curr Opin Gastroenterol. 2018 Sep;34(5):322-329. doi: 10.1097/MOG.0000000000000461.
42 Enhanced fibroblast growth factor 5 expression in stromal and exocrine elements of the pancreas in chronic pancreatitis.Gut. 1998 Jul;43(1):134-9. doi: 10.1136/gut.43.1.134.
43 A microRNA signature in circulating exosomes is superior to exosomal glypican-1 levels for diagnosing pancreatic cancer.Cancer Lett. 2017 May 1;393:86-93. doi: 10.1016/j.canlet.2017.02.019. Epub 2017 Feb 20.
44 Homozygous missense mutation (G56R) in glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 (GPI-HBP1) in two siblings with fasting chylomicronemia (MIM 144650).Lipids Health Dis. 2007 Sep 20;6:23. doi: 10.1186/1476-511X-6-23.
45 Significance of MUC2 gene methylation detection in pancreatic cancer diagnosis.Pancreatology. 2019 Dec;19(8):1049-1053. doi: 10.1016/j.pan.2019.09.012. Epub 2019 Sep 27.
46 Evidence of Notch pathway activation in the ectatic ducts of chronic pancreatitis.J Pathol. 2008 Feb;214(3):312-9. doi: 10.1002/path.2293.
47 Adhesion molecules and pancreatitis.J Gastroenterol. 2019 Feb;54(2):99-107. doi: 10.1007/s00535-018-1500-0. Epub 2018 Aug 23.
48 The common truncation variant in pancreatic lipase related protein 2 (PNLIPRP2) is expressed poorly and does not alter risk for chronic pancreatitis.PLoS One. 2018 Nov 8;13(11):e0206869. doi: 10.1371/journal.pone.0206869. eCollection 2018.
49 RB1CC1-enhanced autophagy facilitates PSCs activation and pancreatic fibrogenesis in chronic pancreatitis.Cell Death Dis. 2018 Sep 20;9(10):952. doi: 10.1038/s41419-018-0980-4.
50 Acceleration of pancreatic tumorigenesis under immunosuppressive microenvironment induced by Reg3g overexpression.Cell Death Dis. 2017 Sep 7;8(9):e3033. doi: 10.1038/cddis.2017.424.
51 Polymorphisms at PRSS1-PRSS2 and CLDN2-MORC4 loci associate with alcoholic and non-alcoholic chronic pancreatitis in a European replication study.Gut. 2015 Sep;64(9):1426-33. doi: 10.1136/gutjnl-2014-307453. Epub 2014 Sep 24.
52 STX12 lncRNA/miR-148a/SMAD5 participate in the regulation of pancreatic stellate cell activation through a mechanism involving competing endogenous RNA.Pancreatology. 2017 Mar-Apr;17(2):237-246. doi: 10.1016/j.pan.2017.01.010. Epub 2017 Feb 1.
53 SPOP inhibits mice pancreatic stellate cell activation by promoting FADD degradation in cerulein-induced chronic pancreatitis.Exp Cell Res. 2019 Nov 1;384(1):111606. doi: 10.1016/j.yexcr.2019.111606. Epub 2019 Sep 4.
54 Hic-5 deficiency protects cerulein-induced chronic pancreatitis via down-regulation of the NF-B (p65)/IL-6 signalling pathway.J Cell Mol Med. 2020 Jan;24(2):1488-1503. doi: 10.1111/jcmm.14833. Epub 2019 Dec 3.
55 In chronic pancreatitis, widespread emergence of TRAIL receptors in epithelia coincides with neoexpression of TRAIL by pancreatic stellate cells of early fibrotic areas.Lab Invest. 2003 Jun;83(6):825-36. doi: 10.1097/01.lab.0000073126.56932.46.
56 Sequence analysis of the human tyrosylprotein sulfotransferase-2 gene in subjects with chronic pancreatitis.Pancreatology. 2010;10(2-3):165-72. doi: 10.1159/000231979. Epub 2010 May 12.
57 Fibromodulin is upregulated by oxidative stress through the MAPK/AP-1 pathway to promote pancreatic stellate cell activation.Pancreatology. 2020 Mar;20(2):278-287. doi: 10.1016/j.pan.2019.09.011. Epub 2019 Sep 26.
58 ATF6 regulates the development of chronic pancreatitis by inducing p53-mediated apoptosis.Cell Death Dis. 2019 Sep 10;10(9):662. doi: 10.1038/s41419-019-1919-0.
59 p38MAPK suppresses chronic pancreatitis by regulating HSP27 and BAD expression.Free Radic Biol Med. 2012 Jun 1-15;52(11-12):2284-91. doi: 10.1016/j.freeradbiomed.2012.03.010. Epub 2012 Apr 16.
60 Comparison of antioxidative and antifibrotic effects of -tocopherol with those of tocotrienol-rich fraction in a rat model of chronic pancreatitis.Pancreas. 2011 Oct;40(7):1091-6. doi: 10.1097/MPA.0b013e31821b59c6.
61 Cytoglobin/STAP, its unique localization in splanchnic fibroblast-like cells and function in organ fibrogenesis.Lab Invest. 2004 Jan;84(1):91-101. doi: 10.1038/labinvest.3700013.
62 Serum levels of Wisteria floribunda agglutinin-positive Mac-2 binding protein reflect the severity of chronic pancreatitis.J Dig Dis. 2017 May;18(5):302-308. doi: 10.1111/1751-2980.12475.
63 NADPH oxidase 1 mediates caerulein-induced pancreatic fibrosis in chronic pancreatitis.Free Radic Biol Med. 2020 Feb 1;147:139-149. doi: 10.1016/j.freeradbiomed.2019.11.034. Epub 2019 Dec 16.
64 Low RASSF6 expression in pancreatic ductal adenocarcinoma is associated with poor survival.World J Gastroenterol. 2015 Jun 7;21(21):6621-30. doi: 10.3748/wjg.v21.i21.6621.
65 Short tandem repeat polymorphisms of exon 4 in Kazal-type gene ECRG2 in pancreatic carcinoma and chronic pancreatitis.Anticancer Res. 2007 Jan-Feb;27(1A):69-73.
66 Common variants in the CLDN2-MORC4 and PRSS1-PRSS2 loci confer susceptibility to acute pancreatitis.Pancreatology. 2018 Jul;18(5):477-481. doi: 10.1016/j.pan.2018.05.486. Epub 2018 Jun 1.
67 Antimicrobial Peptide Human Neutrophil Peptide 1 as a Potential Link Between Chronic Inflammation and Ductal Adenocarcinoma of the Pancreas.Pancreas. 2018 May/Jun;47(5):561-567. doi: 10.1097/MPA.0000000000001054.
68 Caerulein-induced pancreatitis augments the expression and phosphorylation of collapsin response mediator protein 4.J Hepatobiliary Pancreat Sci. 2016 Jul;23(7):422-31. doi: 10.1002/jhbp.361. Epub 2016 Jun 12.
69 FXYD3 is overexpressed in pancreatic ductal adenocarcinoma and influences pancreatic cancer cell growth.Int J Cancer. 2006 Jan 1;118(1):43-54. doi: 10.1002/ijc.21257.
70 Keratin 8 mutations are not associated with familial, sporadic and alcoholic pancreatitis in a population from the United States.Pancreatology. 2006;6(1-2):103-8. doi: 10.1159/000090029. Epub 2005 Dec 1.
71 Do pancreatic cancer and chronic pancreatitis share the same genetic risk factors? A PANcreatic Disease ReseArch (PANDoRA) consortium investigation.Int J Cancer. 2018 Jan 15;142(2):290-296. doi: 10.1002/ijc.31047. Epub 2017 Oct 16.
72 Evaluation of MSX2 mRNA in brush cytology specimens distinguished pancreatic carcinoma from chronic pancreatitis.Cancer Sci. 2011 Jan;102(1):157-61. doi: 10.1111/j.1349-7006.2010.01759.x. Epub 2010 Oct 21.
73 Mucin expression pattern in pancreatic diseases: findings from EUS-guided fine-needle aspiration biopsies.Am J Gastroenterol. 2011 Jul;106(7):1359-63. doi: 10.1038/ajg.2011.22. Epub 2011 Jun 7.
74 PRDM14 is overexpressed in chronic pancreatitis prior to pancreatic cancer.FEBS Open Bio. 2018 Sep 17;8(10):1733-1741. doi: 10.1002/2211-5463.12519. eCollection 2018 Oct.
75 Mesotrypsin Signature Mutation in a Chymotrypsin C (CTRC) Variant Associated with Chronic Pancreatitis.J Biol Chem. 2015 Jul 10;290(28):17282-92. doi: 10.1074/jbc.M114.618439. Epub 2015 May 26.
76 Acinar cell-specific knockout of the PTHrP gene decreases the proinflammatory and profibrotic responses in pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2014 Sep 1;307(5):G533-49. doi: 10.1152/ajpgi.00428.2013. Epub 2014 Jul 17.
77 Is genetic analysis helpful for diagnosing chronic pancreatitis in its early stage?.J Gastroenterol. 2007 Jan;42 Suppl 17:60-5. doi: 10.1007/s00535-006-1934-7.
78 Tumor-suppressor function of SPARC-like protein 1/Hevin in pancreatic cancer.Neoplasia. 2007 Jan;9(1):8-17. doi: 10.1593/neo.06646.
79 Validation of Demographics, Etiology, and Risk Factors for Chronic Pancreatitis in the USA: A Report of the North American Pancreas Study (NAPS) Group.Dig Dis Sci. 2017 Aug;62(8):2133-2140. doi: 10.1007/s10620-017-4621-z. Epub 2017 Jun 9.
80 Serological diagnosis and prognosis of severe acute pancreatitis by analysis of serum glycoprotein 2.Clin Chem Lab Med. 2017 May 1;55(6):854-864. doi: 10.1515/cclm-2016-0797.