Details of Disease

General Information of Disease (ID: DIS0IJEF)

Disease Name	Pancreatitis
Synonyms	pancreas inflammation; inflammation of pancreas
Disease Class	DC31-DC34: Pancreatitis
Definition	Inflammation of the pancreas.
Disease Hierarchy	DIS184KT: Skin inflammation DISWD40R: Disease DISDH7NI: Pancreas disorder DIS0IJEF: Pancreatitis
ICD Code	ICD-11 ICD-11: DC31-DC34 Expand ICD-9 577
Disease Identifiers	MONDO ID MONDO_0004982 MESH ID D010195 UMLS CUI C0030305 MedGen ID 14586 HPO ID HP:0001733 SNOMED CT ID 75694006

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 4 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Eupatilin	DMD02QS	Approved	Small molecular drug	[1]
Gabexate	DMU9D2F	Approved	Small molecular drug	[2]
Methantheline	DM8X4A1	Approved	Small molecular drug	[1]
Nafamostat	DMU1XOD	Approved	Small molecular drug	[3]
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This Disease is Treated as An Indication in 2 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
GSK065	DMO87YS	Phase 1	Small molecular drug	[4]
PMID15026062C41	DMJGFLD	Clinical trial	Small molecular drug	[5]
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This Disease is Treated as An Indication in 1 Patented Agent(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
PMID27998201-Compound-22	DMS9QA7	Patented	Small molecular drug	[6]
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This Disease is Treated as An Indication in 2 Preclinical Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
GSK180	DMNU3SI	Preclinical	Small molecular drug	[4]
GSK366	DM04UGQ	Preclinical	Small molecular drug	[4]
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This Disease is Treated as An Indication in 1 Discontinued Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
R-102444	DM46YHG	Terminated	NA	[7]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 80 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
AGR2	TT9K86S	Limited	Biomarker	[8]
ALB	TTFNGC9	Limited	Biomarker	[9]
CEL	TTTRNQW	Limited	Biomarker	[10]
CNR1	TT6OEDT	Limited	Biomarker	[11]
CPA1	TT3LJ6G	Limited	Biomarker	[12]
CTSG	TTQAJF1	Limited	Altered Expression	[13]
FGF21	TTQ916P	Limited	Altered Expression	[14]
HGF	TT4V2JM	Limited	Therapeutic	[15]
HTR2A	TTJQOD7	Limited	Biomarker	[16]
INS	TTZOPHG	Limited	Biomarker	[17]
PAK4	TT7Y3BZ	Limited	Biomarker	[18]
PNLIP	TTXMY0J	Limited	Biomarker	[10]
PPID	TTNAFOU	Limited	Biomarker	[19]
PPIF	TTRFQTB	Limited	Biomarker	[19]
S100A12	TTQ4ESF	Limited	Biomarker	[20]
SLCO1B3	TTU86P0	Limited	Biomarker	[21]
TICAM1	TT2GQT6	Limited	Biomarker	[22]
TUSC2	TTJ8O14	Limited	Altered Expression	[23]
IL18	TTRICUF	moderate	Biomarker	[24]
SERPINA1	TTA7UJC	moderate	Biomarker	[25]
AMY2A	TTCGSZ4	Strong	Biomarker	[26]
APOA4	TTNC3WS	Strong	Biomarker	[27]
ASPA	TT6TLZP	Strong	Biomarker	[28]
BDKRB2	TTGY8IW	Strong	Biomarker	[29]
CASP3	TTPF2QI	Strong	Biomarker	[30]
CAV1	TTXUBN2	Strong	Altered Expression	[31]
CCK	TT90CMU	Strong	Biomarker	[32]
CCL5	TT9DWLC	Strong	Genetic Variation	[33]
CD14	TT6I7DC	Strong	Genetic Variation	[34]
CD4	TTN2JFW	Strong	Biomarker	[35]
CDC20	TTBKFDV	Strong	Altered Expression	[36]
CNR2	TTMSFAW	Strong	Biomarker	[37]
CTLA4	TTI2S1D	Strong	Genetic Variation	[38]
CTRC	TT3RMNA	Strong	Biomarker	[39]
CTSB	TTF2LRI	Strong	Biomarker	[13]
CTSL	TT36ETB	Strong	Biomarker	[40]
DUSP1	TTG8HIM	Strong	Biomarker	[41]
DUSP10	TTF3RJ0	Strong	Biomarker	[41]
EGR1	TTE8LGD	Strong	Biomarker	[42]
EHMT1	TTOFXD7	Strong	Genetic Variation	[43]
FGG	TTR31L7	Strong	Biomarker	[44]
FGL2	TTYBS89	Strong	Biomarker	[45]
GLP1R	TTVIMDE	Strong	Genetic Variation	[43]
HLA-DQA1	TTU2I3J	Strong	Genetic Variation	[46]
HLA-DRB1	TTUXSTW	Strong	Genetic Variation	[46]
HSP90AB1	TTH5YN2	Strong	Biomarker	[47]
ICAM1	TTA1L39	Strong	Therapeutic	[48]
IL13	TT0GVCH	Strong	Biomarker	[49]
IL15	TTJFA35	Strong	Biomarker	[50]
KLK1	TT5T3P6	Strong	Biomarker	[51]
LAMP2	TTULDG7	Strong	Biomarker	[52]
LEPR	TT0HD6V	Strong	Biomarker	[53]
LIPE	TTLUQ8E	Strong	Biomarker	[54]
LPL	TTOF3WZ	Strong	Altered Expression	[55]
MANF	TT56RYE	Strong	Biomarker	[56]
MDM2	TT9TE0O	Strong	Biomarker	[57]
MPO	TTVCZPI	Strong	Biomarker	[58]
NOD2	TTYPUHA	Strong	Biomarker	[59]
OTC	TT5KIO9	Strong	Genetic Variation	[60]
PDGFA	TTSM78N	Strong	Biomarker	[61]
PPARG	TTT2SVW	Strong	Altered Expression	[62]
PPP3CA	TTA4LDE	Strong	Biomarker	[63]
PPY	TTIB95A	Strong	Biomarker	[64]
PRTN3	TT5MLC4	Strong	Altered Expression	[13]
PSEN2	TTWN3F4	Strong	Biomarker	[65]
REG3A	TTL4H8N	Strong	Altered Expression	[66]
RIPK2	TTCQ2E5	Strong	Biomarker	[67]
SELL	TT2IYXF	Strong	Biomarker	[68]
SMO	TT8J1S3	Strong	Biomarker	[69]
SST	TTWF7UG	Strong	Biomarker	[70]
ST8SIA4	TTDP8YM	Strong	Genetic Variation	[71]
STC2	TT4EFTR	Strong	Biomarker	[72]
SULF2	TTLQTHB	Strong	Genetic Variation	[73]
TACR1	TTZPO1L	Strong	Biomarker	[74]
TDGF1	TTN7HMG	Strong	Altered Expression	[75]
TLR2	TTY7ZHS	Strong	Biomarker	[76]
TLR3	TTD24Y0	Strong	Biomarker	[22]
TRPV1	TTMI6F5	Strong	Biomarker	[77]
USP14	TTVSYP9	Strong	Genetic Variation	[78]
XDH	TT7RJY8	Strong	Genetic Variation	[79]
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⏷ Show the Full List of 80 DTT(s)

This Disease Is Related to 2 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
ABCB4	DTZRMK5	Limited	Autosomal dominant	[80]
SLC12A2	DTHKL3Q	Strong	Biomarker	[81]
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This Disease Is Related to 7 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
ACP3	DEDW5H6	Limited	Altered Expression	[23]
AKR1A1	DED2FW3	Limited	Biomarker	[82]
ADH1B	DEEN9RD	Strong	Genetic Variation	[83]
ADH1C	DEM1HNL	Strong	Genetic Variation	[84]
ADH4	DEOCWU3	Strong	Genetic Variation	[85]
ASNS	DEXISVQ	Strong	Genetic Variation	[86]
GPT	DER5HFI	Strong	Altered Expression	[87]
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⏷ Show the Full List of 7 DME(s)

This Disease Is Related to 79 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ABCB4	OTE6PY83	Limited	Autosomal dominant	[80]
AMT	OTQYEWZQ	Limited	Genetic Variation	[88]
APOA5	OTEVKLVA	Limited	Genetic Variation	[89]
ASAP1	OT4DLRYY	Limited	Altered Expression	[23]
ASAP2	OTGEXULW	Limited	Altered Expression	[23]
CTRB1	OTFFF738	Limited	Genetic Variation	[90]
GATA1	OTX1R7O1	Limited	Biomarker	[91]
GOLGA6A	OTHU9MRX	Limited	Genetic Variation	[92]
GPIHBP1	OTDF8R2M	Limited	Genetic Variation	[93]
HHIP	OT77RQYS	Limited	Altered Expression	[94]
LMF1	OTOL14ZD	Limited	Biomarker	[95]
MRPS30	OTDXIAGG	Limited	Altered Expression	[23]
MTPAP	OT6HQ02S	Limited	Altered Expression	[23]
NUPR1	OT4FU8C0	Limited	Altered Expression	[96]
PAPOLA	OTPHD65D	Limited	Altered Expression	[23]
PDAP1	OTJSWMOD	Limited	Altered Expression	[23]
PNLIPRP2	OTJG6BA7	Limited	Biomarker	[10]
RCBTB1	OTAYELI8	Limited	Genetic Variation	[92]
TIGAR	OTR7NMRJ	Limited	Biomarker	[97]
APOC2	OTLINYIQ	moderate	Genetic Variation	[93]
CLDN2	OTRF3D6Y	moderate	Genetic Variation	[98]
A1CF	OTJBKFA1	Strong	Biomarker	[28]
ABCF1	OT6Q079J	Strong	Biomarker	[99]
ADGRE2	OTUYJVYG	Strong	Biomarker	[100]
ADGRE5	OTTSB84Q	Strong	Biomarker	[100]
ANLN	OTXJY54C	Strong	Biomarker	[101]
AP2S1	OTEV2XGW	Strong	Genetic Variation	[102]
ARFRP1	OTP1OV78	Strong	Biomarker	[56]
ATP2C2	OTGIHTYQ	Strong	Altered Expression	[103]
ATP8B1	OTALGS63	Strong	Biomarker	[104]
BNIP3L	OTJKOMXE	Strong	Biomarker	[105]
BTBD8	OT3A3RD7	Strong	Biomarker	[106]
CASP12	OTY2W6FG	Strong	Biomarker	[30]
CCL1	OT23NON8	Strong	Genetic Variation	[107]
CETN1	OTGQ8JOZ	Strong	Biomarker	[108]
CNPY2	OTGY8ESX	Strong	Biomarker	[109]
CRISP1	OTDI4B55	Strong	Biomarker	[56]
CRISPLD2	OTVSFHTL	Strong	Biomarker	[110]
CTRB2	OTR9TOBV	Strong	Genetic Variation	[90]
CUZD1	OTDQJVZ8	Strong	Altered Expression	[111]
DPYSL3	OTINJV20	Strong	Altered Expression	[112]
DSPP	OT1TYNDN	Strong	Genetic Variation	[113]
DUSP6	OT4H6RKW	Strong	Biomarker	[41]
EBPL	OT59J1GY	Strong	Biomarker	[114]
FDX1	OT7I3DN0	Strong	Biomarker	[115]
FGA	OTMIHY80	Strong	Biomarker	[44]
FGB	OT6RKLI9	Strong	Biomarker	[44]
HRG	OTPLUFOG	Strong	Biomarker	[116]
IER3	OTZJI5FZ	Strong	Biomarker	[117]
IFITM3	OT2QP8D3	Strong	Altered Expression	[118]
IGSF9	OTNTKWS2	Strong	Altered Expression	[119]
MORC4	OTJBEHNE	Strong	Genetic Variation	[98]
MYBBP1A	OTIVEMIU	Strong	Genetic Variation	[120]
NBL1	OTT37U4O	Strong	Altered Expression	[101]
NRDC	OTWBBCXO	Strong	Biomarker	[121]
NUDT15	OTX8SZOT	Strong	Genetic Variation	[122]
PDZD2	OTPPVRGY	Strong	Biomarker	[123]
PIAS3	OT3TWH9R	Strong	Altered Expression	[124]
PPP3CB	OTEGNEHW	Strong	Biomarker	[125]
PRDM14	OTWZKY4L	Strong	Altered Expression	[126]
PRSS3	OTN3S5YB	Strong	Biomarker	[127]
PRSS58	OTVUH7KR	Strong	Genetic Variation	[128]
PYCR1	OTQHB52T	Strong	Biomarker	[129]
QTRT1	OTC33MCV	Strong	Genetic Variation	[78]
RAMP1	OT7UT2XB	Strong	Biomarker	[20]
REG1B	OTSC2133	Strong	Altered Expression	[130]
RERE	OT3G4GBZ	Strong	Biomarker	[56]
RIPPLY1	OT19XBFD	Strong	Genetic Variation	[131]
ROPN1L	OTRWZJ68	Strong	Biomarker	[28]
RPL29	OTUFIBJL	Strong	Biomarker	[132]
SARAF	OTH5JIFE	Strong	Biomarker	[133]
SDF4	OTQ7WFYW	Strong	Biomarker	[108]
SPEF2	OTO04K1T	Strong	Genetic Variation	[120]
ST13	OTNML6UP	Strong	Biomarker	[132]
STX2	OTO2IDDR	Strong	Biomarker	[134]
STXBP3	OTTTYMAQ	Strong	Biomarker	[135]
SULF1	OTJCNCO0	Strong	Genetic Variation	[73]
TFIP11	OT7NVSWU	Strong	Altered Expression	[119]
TRIM69	OTTEGTRD	Strong	Biomarker	[136]
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⏷ Show the Full List of 79 DOT(s)

References

1	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7863).
3	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4262).
4	Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond. Nat Rev Drug Discov. 2019 May;18(5):379-401.
5	Carbazates as potent inhibitors of hormone-sensitive lipase. Bioorg Med Chem Lett. 2004 Apr 5;14(7):1741-4.
6	Cathepsin B and L inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2017 Jun;27(6):643-656.
7	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800015510)
8	Anterior Gradient 2 (AGR2) Induced Epidermal Growth Factor Receptor (EGFR) Signaling Is Essential for Murine Pancreatitis-Associated Tissue Regeneration.PLoS One. 2016 Oct 20;11(10):e0164968. doi: 10.1371/journal.pone.0164968. eCollection 2016.
9	Evaluation of two novel peptide safety markers for exocrine pancreatic toxicity.Toxicol Sci. 2007 Mar;96(1):184-93. doi: 10.1093/toxsci/kfl190. Epub 2006 Dec 14.
10	Carboxyl Ester Lipase May Not Mediate Lipotoxic Injury during Severe Acute Pancreatitis.Am J Pathol. 2019 Jun;189(6):1226-1240. doi: 10.1016/j.ajpath.2019.02.015. Epub 2019 Apr 5.
11	Cannabinoids ameliorate pain and reduce disease pathology in cerulein-induced acute pancreatitis.Gastroenterology. 2007 May;132(5):1968-78. doi: 10.1053/j.gastro.2007.02.035. Epub 2007 Feb 21.
12	Genetics of pancreatitis: the 2014 update.Tohoku J Exp Med. 2014 Feb;232(2):69-77. doi: 10.1620/tjem.232.69.
13	Deficiency of cathepsin C ameliorates severity of acute pancreatitis by reduction of neutrophil elastase activation and cleavage of E-cadherin.J Biol Chem. 2019 Jan 11;294(2):697-707. doi: 10.1074/jbc.RA118.004376. Epub 2018 Nov 19.
14	FGF21 Is an Exocrine Pancreas Secretagogue.Cell Metab. 2017 Feb 7;25(2):472-480. doi: 10.1016/j.cmet.2016.12.004. Epub 2017 Jan 12.
15	Inhibition of cyclooxygenase-2 reduces the protective effect of hepatocyte growth factor in experimental pancreatitis.Eur J Pharmacol. 2004 Feb 13;486(1):107-19. doi: 10.1016/j.ejphar.2003.12.015.
16	Effects of R-102444 and its active metabolite R-96544, selective 5-HT2A receptor antagonists, on experimental acute and chronic pancreatitis: Additional evidence for possible involvement of 5-HT2A receptors in the development of experimental pancreatitis.Eur J Pharmacol.2005 Oct 3;521(1-3):156-63.
17	Tamoxifen-induced severe hypertriglyceridaemia and acute pancreatitis.Clin Drug Investig. 2006;26(5):297-302. doi: 10.2165/00044011-200626050-00007.
18	P21-activated kinase 4 in pancreatic acinar cells is activated by numerous gastrointestinal hormones/neurotransmitters and growth factors by novel signaling, and its activation stimulates secretory/growth cascades.Am J Physiol Gastrointest Liver Physiol. 2018 Aug 1;315(2):G302-G317. doi: 10.1152/ajpgi.00005.2018. Epub 2018 Apr 19.
19	Novel mitochondrial transition pore inhibitor N-methyl-4-isoleucine cyclosporin is a new therapeutic option in acute pancreatitis.J Physiol. 2019 Dec;597(24):5879-5898. doi: 10.1113/JP278517. Epub 2019 Dec 1.
20	The neuropeptide receptor subunit RAMP1 constrains the innate immune response during acute pancreatitis in mice.Pancreatology. 2019 Jun;19(4):541-547. doi: 10.1016/j.pan.2019.05.455. Epub 2019 May 11.
21	Characterization of OATP1B3 and OATP2B1 transporter expression in the islet of the adult human pancreas.Histochem Cell Biol. 2017 Oct;148(4):345-357. doi: 10.1007/s00418-017-1580-6. Epub 2017 May 10.
22	Loss of TLR3 and its downstream signaling accelerates acinar cell damage in the acute phase of pancreatitis.Pancreatology. 2019 Jan;19(1):149-157. doi: 10.1016/j.pan.2018.12.005. Epub 2018 Dec 15.
23	PAP/REG3A favors perineural invasion in pancreatic adenocarcinoma and serves as a prognostic marker.Cell Mol Life Sci. 2017 Nov;74(22):4231-4243. doi: 10.1007/s00018-017-2579-9. Epub 2017 Jun 27.
24	The role of interleukin-18 in pancreatitis and pancreatic cancer.Cytokine Growth Factor Rev. 2019 Dec;50:1-12. doi: 10.1016/j.cytogfr.2019.11.001. Epub 2019 Nov 9.
25	Hepatic steatosis depresses alpha-1-antitrypsin levels in human and rat acute pancreatitis.Sci Rep. 2015 Dec 4;5:17833. doi: 10.1038/srep17833.
26	Amylase alpha-2A autoantibodies: novel marker of autoimmune pancreatitis and fulminant type 1 diabetes.Diabetes. 2009 Mar;58(3):732-7. doi: 10.2337/db08-0493. Epub 2008 Nov 10.
27	Large-scale clinical validation of biomarkers for pancreatic cancer using a mass spectrometry-based proteomics approach.Oncotarget. 2017 Jun 27;8(26):42761-42771. doi: 10.18632/oncotarget.17463.
28	Severe drug-induced hypertriglyceridemia treated with plasmapheresis in children with acute lymphoblastic leukemia.Transfus Apher Sci. 2019 Oct;58(5):634-637. doi: 10.1016/j.transci.2019.08.025. Epub 2019 Sep 5.
29	Effects of the bradykinin B2 receptor antagonist S 16118 (p-guanidobenzoyl-[Hyp3,Thi5,D-Tic7,Oic8]bradykinin) in different in vivo animal models of inflammation.J Pharmacol Exp Ther. 1995 Jun;273(3):1078-84.
30	Early activation of endoplasmic reticulum stress is associated with arginine-induced acute pancreatitis.Am J Physiol Gastrointest Liver Physiol. 2006 Aug;291(2):G238-45. doi: 10.1152/ajpgi.00471.2005. Epub 2006 Mar 30.
31	Caveolin-1 Modulates Mechanotransduction Responses to Substrate Stiffness through Actin-Dependent Control of YAP.Cell Rep. 2018 Nov 6;25(6):1622-1635.e6. doi: 10.1016/j.celrep.2018.10.024.
32	Cholecystokinin-8 treatment reduces acinar necrosis and edema of pigs with induced pancreatitis.Asian J Surg. 2020 Jan;43(1):272-277. doi: 10.1016/j.asjsur.2019.05.002. Epub 2019 Jun 3.
33	Inflammation, genetic polymorphisms in proinflammatory genes TNF-A, RANTES, and CCR5, and risk of pancreatic adenocarcinoma.Cancer Epidemiol Biomarkers Prev. 2006 Apr;15(4):726-31. doi: 10.1158/1055-9965.EPI-05-0797.
34	CD14 promoter polymorphism in Chinese alcoholic patients with cirrhosis of liver and acute pancreatitis.World J Gastroenterol. 2005 Oct 14;11(38):6043-8. doi: 10.3748/wjg.v11.i38.6043.
35	Circulating nave and CD4+CD25high regulatory T cells in patients with autoimmune pancreatitis.Pancreas. 2008 Mar;36(2):133-40. doi: 10.1097/MPA.0b013e3181577553.
36	Increased CDC20 expression is associated with pancreatic ductal adenocarcinoma differentiation and progression.J Hematol Oncol. 2012 Apr 4;5:15. doi: 10.1186/1756-8722-5-15.
37	Involvement of cannabinoid CB1- and CB2-receptors in the modulation of exocrine pancreatic secretion.Pharmacol Res. 2009 Mar;59(3):207-14. doi: 10.1016/j.phrs.2008.11.002. Epub 2008 Nov 27.
38	Incidence of pancreatitis with the use of immune checkpoint inhibitors (ICI) in advanced cancers: A systematic review and meta-analysis.Pancreatology. 2019 Jun;19(4):587-594. doi: 10.1016/j.pan.2019.04.015. Epub 2019 May 2.
39	Natural single-nucleotide deletion in chymotrypsinogen C gene increases severity of secretagogue-induced pancreatitis in C57BL/6 mice.JCI Insight. 2019 Jun 18;4(14):e129717. doi: 10.1172/jci.insight.129717. Print 2019 Jul 25.
40	Cathepsin L inactivates human trypsinogen, whereas cathepsin L-deletion reduces the severity of pancreatitis in mice.Gastroenterology. 2010 Feb;138(2):726-37. doi: 10.1053/j.gastro.2009.10.048. Epub 2009 Nov 10.
41	Map kinase phosphatases (MKP's) are early responsive genes during induction of cerulein hyperstimulation pancreatitis.Biochem Biophys Res Commun. 2000 Sep 24;276(2):680-5. doi: 10.1006/bbrc.2000.3530.
42	Expression of early growth response factor-1 in rats with cerulein-induced acute pancreatitis and its significance.World J Gastroenterol. 2005 Aug 28;11(32):5022-4. doi: 10.3748/wjg.v11.i32.5022.
43	Comparison of serum amylase level between dipeptidyl peptidase-4 inhibitor and GLP-1 analog administration in patients with type 2 diabetes mellitus.J Health Popul Nutr. 2019 Nov 14;38(1):33. doi: 10.1186/s41043-019-0197-x.
44	Quantitative organellar proteomics analysis of rough endoplasmic reticulum from normal and acute pancreatitis rat pancreas.J Proteome Res. 2010 Feb 5;9(2):885-96. doi: 10.1021/pr900784c.
45	Adenovirus-mediated artificial miRNA targetting fibrinogen-like protein 2 attenuates the severity of acute pancreatitis in mice.Biosci Rep. 2017 Nov 23;37(6):BSR20170964. doi: 10.1042/BSR20170964. Print 2017 Dec 22.
46	HLA-DQA1-HLA-DRB1 polymorphism is a major predictor of azathioprine-induced pancreatitis in patients with inflammatory bowel disease.Aliment Pharmacol Ther. 2018 Mar;47(5):615-620. doi: 10.1111/apt.14483. Epub 2017 Dec 22.
47	Acute pancreatitis: hypertonic saline increases heat shock proteins 70 and 90 and reduces neutrophil infiltration in lung injury.Pancreas. 2009 Jul;38(5):507-14. doi: 10.1097/MPA.0b013e31819fef75.
48	Effects of dexamethasone and Salvia miltiorrhiza on multiple organs in rats with severe acute pancreatitis.J Zhejiang Univ Sci B. 2012 Nov;13(11):919-31. doi: 10.1631/jzus.B1100351.
49	IL-13 promotes the proliferation of rat pancreatic stellate cells through the suppression of NF-kappaB/TGF-beta1 pathway.Biochem Biophys Res Commun. 2010 Feb 26;393(1):61-5. doi: 10.1016/j.bbrc.2010.01.078. Epub 2010 Jan 25.
50	Significant expression of interleukin 15 in rat experimental severe acute pancreatitis.Eur Surg Res. 2010;44(3-4):159-69. doi: 10.1159/000283241. Epub 2010 Mar 24.
51	Mechanism of kinin release during experimental acute pancreatitis in rats: evidence for pro- as well as anti-inflammatory roles of oedema formation.Br J Pharmacol. 2003 May;139(2):299-308. doi: 10.1038/sj.bjp.0705247.
52	Impaired autolysosome formation correlates with Lamp-2 depletion: role of apoptosis, autophagy, and necrosis in pancreatitis.Gastroenterology. 2009 Jul;137(1):350-60, 360.e1-5. doi: 10.1053/j.gastro.2009.04.003. Epub 2009 Apr 9.
53	Progression of pancreatitis prior to diabetes onset in WBN/Kob-Lepr(fa) rats.J Vet Med Sci. 2012 Jan;74(1):65-70. doi: 10.1292/jvms.11-0168. Epub 2011 Aug 12.
54	Deficiency in hormone-sensitive lipase accelerates the development of pancreatic cancer in conditional KrasG12D mice.BMC Cancer. 2018 Aug 7;18(1):797. doi: 10.1186/s12885-018-4713-y.
55	A lipoprotein lipase-GPI-anchored high-density lipoprotein-binding protein 1 fusion lowers triglycerides in mice: Implications for managing familial chylomicronemia syndrome.J Biol Chem. 2020 Mar 6;295(10):2900-2912. doi: 10.1074/jbc.RA119.011079. Epub 2019 Oct 23.
56	An Evaluation of Factors Associated With Pathogenic PRSS1, SPINK1, CTFR, and/or CTRC Genetic Variants in Patients With Idiopathic Pancreatitis.Am J Gastroenterol. 2017 Aug;112(8):1320-1329. doi: 10.1038/ajg.2017.106. Epub 2017 Apr 25.
57	Inflammatory cells regulate p53 and caspases in acute pancreatitis.Am J Physiol Gastrointest Liver Physiol. 2010 Jan;298(1):G92-100. doi: 10.1152/ajpgi.00324.2009. Epub 2009 Oct 22.
58	Extracellular release of ATP promotes systemic inflammation during acute pancreatitis.Am J Physiol Gastrointest Liver Physiol. 2019 Oct 1;317(4):G463-G475. doi: 10.1152/ajpgi.00395.2018. Epub 2019 Aug 21.
59	Expression of NOD2 in a rat model of acute pancreatitis.Pancreas. 2010 Oct;39(7):1034-40. doi: 10.1097/MPA.0b013e3181da0f1d.
60	Ornithine transcarbamylase deficiency and pancreatitis.J Pediatr. 2001 Jan;138(1):123-4. doi: 10.1067/mpd.2001.109792.
61	Effect of ischemic preconditioning on pancreatic regeneration and pancreatic expression of vascular endothelial growth factor and platelet-derived growth factor-A in ischemia/reperfusion-induced pancreatitis.J Physiol Pharmacol. 2006 Mar;57(1):39-58.
62	New wine into old wineskins: PGC-1 and NF-B in obesity and acute pancreatitis.J Pathol. 2019 May;248(1):6-8. doi: 10.1002/path.5220. Epub 2019 Feb 11.
63	Exocrine pancreatic carcinogenesis and autotaxin expression. PLoS One. 2012;7(8):e43209. doi: 10.1371/journal.pone.0043209. Epub 2012 Aug 29.
64	Pancreatic polypeptide in pancreatitis.Peptides. 2002 Feb;23(2):331-8. doi: 10.1016/s0196-9781(01)00605-2.
65	Localisation of presenilin 2 in human and rodent pancreatic islet beta-cells; Met239Val presenilin 2 variant is not associated with diabetes in man.J Cell Sci. 1999 Jul;112 ( Pt 13):2137-44. doi: 10.1242/jcs.112.13.2137.
66	Eckol inhibits Reg3A-induced proliferation of human SW1990 pancreatic cancer cells.Exp Ther Med. 2019 Oct;18(4):2825-2832. doi: 10.3892/etm.2019.7889. Epub 2019 Aug 14.
67	Identification and Characterization of Novel Receptor-Interacting Serine/Threonine-Protein Kinase 2 Inhibitors Using Structural Similarity Analysis.J Pharmacol Exp Ther. 2018 May;365(2):354-367. doi: 10.1124/jpet.117.247163. Epub 2018 Mar 19.
68	Protein kinase C modulates the pulmonary inflammatory response in acute pancreatitis.Respir Physiol Neurobiol. 2006 May;152(1):16-26. doi: 10.1016/j.resp.2005.07.005. Epub 2005 Oct 7.
69	Expression of sonic hedgehog signaling pathways in a rat model of chronic pancreatitis.Saudi Med J. 2010 Jan;31(1):14-7.
70	Comparative Efficacy of 9 Major Drugs for Postendoscopic Retrograde Cholangiopancreatography Pancreatitis: A Network Meta-Analysis.Surg Laparosc Endosc Percutan Tech. 2019 Dec;29(6):426-432. doi: 10.1097/SLE.0000000000000707.
71	Idiopathic pancreatitis related to CFTR: complex inheritance and identification of a modifier gene.J Investig Med. 2002 Sep;50(5):247S-255S. doi: 10.1136/jim-50-suppl5-01.
72	Stanniocalcin 2 alters PERK signalling and reduces cellular injury during cerulein induced pancreatitis in mice.BMC Cell Biol. 2011 May 5;12:17. doi: 10.1186/1471-2121-12-17.
73	SULF1/SULF2 splice variants differentially regulate pancreatic tumour growth progression.Exp Cell Res. 2014 Jun 10;324(2):157-71. doi: 10.1016/j.yexcr.2014.04.001. Epub 2014 Apr 12.
74	Role of substance P and bradykinin in acute pancreatitis induced by secretory phospholipase A2.Pancreas. 2008 Jul;37(1):50-5. doi: 10.1097/MPA.0b013e3185d9b9b.
75	Expression of cripto in human pancreatic tumors.Jpn J Cancer Res. 1994 Feb;85(2):118-21. doi: 10.1111/j.1349-7006.1994.tb02069.x.
76	Expression of toll-like receptor 2 and 4 in intestinal mucosa in experimental severe acute pancreatitis.Hepatogastroenterology. 2008 Nov-Dec;55(88):2247-51.
77	The role of Transient Receptor Potential Vanilloid 1 (TRPV1) channels in pancreatitis.Biochim Biophys Acta. 2007 Aug;1772(8):869-78. doi: 10.1016/j.bbadis.2007.02.012. Epub 2007 Mar 12.
78	Identification of a novel pancreatitis-associated missense mutation, R116C, in the human cationic trypsinogen gene (PRSS1).Mol Genet Metab. 2001 Nov;74(3):342-4. doi: 10.1006/mgme.2001.3246.
79	Gene polymorphisms involved in manifestation of leucopenia, digestive intolerance, and pancreatitis in azathioprine-treated patients.Dig Dis Sci. 2012 Sep;57(9):2394-401. doi: 10.1007/s10620-012-2163-y. Epub 2012 Apr 26.
80	Classification of Genes: Standardized Clinical Validity Assessment of Gene-Disease Associations Aids Diagnostic Exome Analysis and Reclassifications. Hum Mutat. 2017 May;38(5):600-608. doi: 10.1002/humu.23183. Epub 2017 Feb 13.
81	Quantitative Ultrasound and the Pancreas: Demonstration of Early Detection Capability.J Ultrasound Med. 2019 Aug;38(8):2093-2102. doi: 10.1002/jum.14901. Epub 2018 Dec 21.
82	The Alcohol Dehydrogenase Isoenzyme as a Potential Marker of Pancreatitis.Anticancer Res. 2018 May;38(5):3019-3024. doi: 10.21873/anticanres.12556.
83	SPINK1, ADH2, and ALDH2 gene variants and alcoholic chronic pancreatitis in Japan.J Gastroenterol Hepatol. 2008 Mar;23 Suppl 1:S82-6. doi: 10.1111/j.1440-1746.2007.05291.x.
84	Association between alcohol dehydrogenase 1C gene 1/2 polymorphism and pancreatitis risk: a meta-analysis.Genet Mol Res. 2015 Nov 30;14(4):15267-75. doi: 10.4238/2015.November.30.2.
85	Genotypes of alcohol-metabolizing enzymes in relation to alcoholic chronic pancreatitis in Japan.Alcohol Clin Exp Res. 1999 Apr;23(4 Suppl):85S-91S. doi: 10.1111/j.1530-0277.1999.tb04541.x.
86	Polymorphisms of asparaginase pathway and asparaginase-related complications in children with acute lymphoblastic leukemia.Clin Cancer Res. 2015 Jan 15;21(2):329-34. doi: 10.1158/1078-0432.CCR-14-0508. Epub 2014 Jun 6.
87	Ethyl pyruvate treatment ameliorates pancreatic damage: evidence from a rat model of acute necrotizing pancreatitis.Arch Med Sci. 2019 Jan;15(1):232-239. doi: 10.5114/aoms.2017.65231. Epub 2017 Jan 23.
88	Alipogene tiparvovec: a review of its use in adults with familial lipoprotein lipase deficiency.Drugs. 2015 Feb;75(2):175-82. doi: 10.1007/s40265-014-0339-9.
89	Severe hypertriglyceridaemia and pancreatitis in a patient with lipoprotein lipase deficiency based on mutations in lipoprotein lipase (LPL) and apolipoprotein A5 (APOA5) genes.BMJ Case Rep. 2019 Apr 3;12(4):e228199. doi: 10.1136/bcr-2018-228199.
90	Genome-wide association study identifies inversion in the CTRB1-CTRB2 locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis.Gut. 2018 Oct;67(10):1855-1863. doi: 10.1136/gutjnl-2017-314454. Epub 2017 Jul 28.
91	Role of eosinophils in the initiation and progression of pancreatitis pathogenesis.Am J Physiol Gastrointest Liver Physiol. 2018 Feb 1;314(2):G211-G222. doi: 10.1152/ajpgi.00210.2017. Epub 2017 Sep 21.
92	Pancreatitis Incidence in the Exenatide BID, Exenatide QW, and Exenatide QW Suspension Development Programs: Pooled Analysis of 35 Clinical Trials.Diabetes Ther. 2019 Aug;10(4):1249-1270. doi: 10.1007/s13300-019-0627-1. Epub 2019 May 10.
93	Extreme hypertriglyceridemia: Genetic diversity, pancreatitis, pregnancy, and prevalence.J Clin Lipidol. 2019 Jan-Feb;13(1):89-99. doi: 10.1016/j.jacl.2018.09.007. Epub 2018 Sep 18.
94	Hedgehog Interacting Protein (Hhip) Regulates Insulin Secretion in Mice Fed High Fat Diets.Sci Rep. 2019 Aug 1;9(1):11183. doi: 10.1038/s41598-019-47633-3.
95	Genetic Variants Associated with Gestational Hypertriglyceridemia and Pancreatitis.PLoS One. 2015 Jun 16;10(6):e0129488. doi: 10.1371/journal.pone.0129488. eCollection 2015.
96	Dendrimers as Competitors of Protein-Protein Interactions of the Intrinsically Disordered Nuclear Chromatin Protein NUPR1.Biomacromolecules. 2019 Jul 8;20(7):2567-2576. doi: 10.1021/acs.biomac.9b00378. Epub 2019 Jun 24.
97	Pancreatitis: TIGAR-O Version 2 Risk/Etiology Checklist With Topic Reviews, Updates, and Use Primers.Clin Transl Gastroenterol. 2019 Jun;10(6):e00027. doi: 10.14309/ctg.0000000000000027.
98	Effects of PRSS1-PRSS2 rs10273639, CLDN2 rs7057398 and MORC4 rs12688220 polymorphisms on individual susceptibility to pancreatitis: A meta-analysis.Genomics. 2020 Jan;112(1):848-852. doi: 10.1016/j.ygeno.2019.05.025. Epub 2019 Jun 1.
99	Two critical genes (HLA-DRB1 and ABCF1)in the HLA region are associated with the susceptibility to autoimmune pancreatitis.Immunogenetics. 2007 Jan;59(1):45-52. doi: 10.1007/s00251-006-0178-2. Epub 2006 Nov 21.
100	CD97, CD95 and Fas-L clearly discriminate between chronic pancreatitis and pancreatic ductal adenocarcinoma in perioperative evaluation of cryocut sections.Pathol Int. 2002 Feb;52(2):83-8. doi: 10.1046/j.1440-1827.2002.01324.x.
101	NBL1 and anillin (ANLN) genes over-expression in pancreatic carcinoma.Folia Histochem Cytobiol. 2009;47(2):249-55. doi: 10.2478/v10042-009-0031-1.
102	Cinacalcet sustainedly prevents pancreatitis in a child with a compound heterozygous SPINK1/AP2S1 mutation.Pancreatology. 2019 Sep;19(6):801-804. doi: 10.1016/j.pan.2019.07.045. Epub 2019 Jul 30.
103	Atp2c2 Is Transcribed From a Unique Transcriptional Start Site in Mouse Pancreatic Acinar Cells.J Cell Physiol. 2016 Dec;231(12):2768-78. doi: 10.1002/jcp.25391. Epub 2016 Apr 21.
104	Mutational analysis of ATP8B1 in patients with chronic pancreatitis.PLoS One. 2013 Nov 19;8(11):e80553. doi: 10.1371/journal.pone.0080553. eCollection 2013.
105	Increased expression of 19-kD interacting protein-3-like protein and the relationship to apoptosis in the lung of rats with severe acute pancreatitis.Crit Care Med. 2003 Oct;31(10):2527-34. doi: 10.1097/01.CCM.0000090006.49055.6D.
106	Concurrent Diabetic Ketoacidosis in Hypertriglyceridemia-Induced Pancreatitis: How Does It Affect the Clinical Course and Severity Scores?.Pancreas. 2017 Nov/Dec;46(10):1336-1340. doi: 10.1097/MPA.0000000000000937.
107	Short tandem repeat polymorphisms of exon 4 in Kazal-type gene ECRG2 in pancreatic carcinoma and chronic pancreatitis.Anticancer Res. 2007 Jan-Feb;27(1A):69-73.
108	The calcium binding protein S100A9 is essential for pancreatic leukocyte infiltration and induces disruption of cell-cell contacts.J Cell Physiol. 2008 Aug;216(2):558-67. doi: 10.1002/jcp.21433.
109	From moderately severe to severe hypertriglyceridemia induced acute pancreatitis: circulating miRNAs play role as potential biomarkers.PLoS One. 2014 Nov 3;9(11):e111058. doi: 10.1371/journal.pone.0111058. eCollection 2014.
110	Characterization of dsRNA-induced pancreatitis model reveals the regulatory role of IFN regulatory factor 2 (Irf2) in trypsinogen5 gene transcription.Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):18766-71. doi: 10.1073/pnas.1116273108. Epub 2011 Oct 31.
111	Protection from pancreatitis by the zymogen granule membrane protein integral membrane-associated protein-1.J Biol Chem. 2002 Dec 27;277(52):50725-33. doi: 10.1074/jbc.M204159200. Epub 2002 Oct 24.
112	Caerulein-induced pancreatitis augments the expression and phosphorylation of collapsin response mediator protein 4.J Hepatobiliary Pancreat Sci. 2016 Jul;23(7):422-31. doi: 10.1002/jhbp.361. Epub 2016 Jun 12.
113	Nationwide Trends in Pancreatitis and Pancreatic Cancer Risk Among Patients With Newly Diagnosed Type 2 Diabetes Receiving Dipeptidyl Peptidase 4 Inhibitors.Diabetes Care. 2019 Nov;42(11):2057-2064. doi: 10.2337/dc18-2195. Epub 2019 Aug 20.
114	Values of mutations of K-ras oncogene at codon 12 in detection of pancreatic cancer: 15-year experience.World J Gastroenterol. 2004 Feb 15;10(4):471-5. doi: 10.3748/wjg.v10.i4.471.
115	Pancreatic gene expression during the initiation of acute pancreatitis: identification of EGR-1 as a key regulator.Physiol Genomics. 2003 Jun 24;14(1):59-72. doi: 10.1152/physiolgenomics.00174.2002.
116	Histidine-Rich Glycoprotein Suppresses Hyperinflammatory Responses of Lung in a Severe Acute Pancreatitis Mouse Model.Pancreas. 2018 Oct;47(9):1156-1164. doi: 10.1097/MPA.0000000000001153.
117	IER3 supports KRASG12D-dependent pancreatic cancer development by sustaining ERK1/2 phosphorylation.J Clin Invest. 2014 Nov;124(11):4709-22. doi: 10.1172/JCI76037. Epub 2014 Sep 24.
118	Cloning of IP15, a pancreatitis-induced gene whose expression inhibits cell growth.Biochem Biophys Res Commun. 2004 Jul 2;319(3):1001-9. doi: 10.1016/j.bbrc.2004.05.085.
119	Evaluation of neurotensin receptor 1 as a potential imaging target in pancreatic ductal adenocarcinoma.Amino Acids. 2017 Aug;49(8):1325-1335. doi: 10.1007/s00726-017-2430-5. Epub 2017 May 23.
120	Whole-exome sequencing identified genetic risk factors for asparaginase-related complications in childhood ALL patients.Oncotarget. 2017 Jul 4;8(27):43752-43767. doi: 10.18632/oncotarget.17959.
121	Nardilysin inhibits pancreatitis and suppresses pancreatic ductal adenocarcinoma initiation in mice.Gut. 2019 May;68(5):882-892. doi: 10.1136/gutjnl-2017-315425. Epub 2018 May 24.
122	Update on thiopurine pharmacogenetics in inflammatory bowel disease.Pharmacogenomics. 2015 Jul;16(8):891-903. doi: 10.2217/pgs.15.29. Epub 2015 Jun 12.
123	Th2 and regulatory immune reactions are increased in immunoglobin G4-related sclerosing pancreatitis and cholangitis.Hepatology. 2007 Jun;45(6):1538-46. doi: 10.1002/hep.21697.
124	RNA-Seq Analyses of the Role of miR-21 in Acute Pancreatitis.Cell Physiol Biochem. 2018;51(5):2198-2211. doi: 10.1159/000495866. Epub 2018 Dec 7.
125	Exposure to Radiocontrast Agents Induces Pancreatic Inflammation by Activation of Nuclear Factor-B, Calcium Signaling, and Calcineurin.Gastroenterology. 2015 Sep;149(3):753-64.e11. doi: 10.1053/j.gastro.2015.05.004. Epub 2015 May 14.
126	PRDM14 is overexpressed in chronic pancreatitis prior to pancreatic cancer.FEBS Open Bio. 2018 Sep 17;8(10):1733-1741. doi: 10.1002/2211-5463.12519. eCollection 2018 Oct.
127	Human mesotrypsin defies natural trypsin inhibitors: from passive resistance to active destruction.Protein Pept Lett. 2005 Jul;12(5):457-64. doi: 10.2174/0929866054395356.
128	Metastatic pancreatic adenocarcinoma associated with chronic calcific pancreatitis and a heterozygous SPINK1 N34S mutation.Pancreatology. 2016 Sep-Oct;16(5):869-72. doi: 10.1016/j.pan.2016.06.006. Epub 2016 Jun 21.
129	Clusterin and Pycr1 alterations associate with strain and model differences in susceptibility to experimental pancreatitis.Biochem Biophys Res Commun. 2017 Jan 22;482(4):1346-1352. doi: 10.1016/j.bbrc.2016.12.039. Epub 2016 Dec 7.
130	Reg2 Expression Is Required for Pancreatic Islet Compensation in Response to Aging and High-Fat Diet-Induced Obesity.Endocrinology. 2017 Jun 1;158(6):1634-1644. doi: 10.1210/en.2016-1551.
131	Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis. Nat Genet. 2012 Dec;44(12):1349-54. doi: 10.1038/ng.2466. Epub 2012 Nov 11.
132	Structural organization and chromosomal localization of a human gene (HIP/PAP) encoding a C-type lectin overexpressed in primary liver cancer.Eur J Biochem. 1994 Aug 15;224(1):29-38. doi: 10.1111/j.1432-1033.1994.tb19991.x.
133	Ca(2+) Influx Channel Inhibitor SARAF Protects Mice From Acute Pancreatitis.Gastroenterology. 2019 Dec;157(6):1660-1672.e2. doi: 10.1053/j.gastro.2019.08.042. Epub 2019 Sep 4.
134	Pancreatitis-Induced Depletion of Syntaxin 2 Promotes Autophagy and Increases Basolateral Exocytosis.Gastroenterology. 2018 May;154(6):1805-1821.e5. doi: 10.1053/j.gastro.2018.01.025. Epub 2018 Jan 31.
135	Depletion of the membrane-fusion regulator Munc18c attenuates caerulein hyperstimulation-induced pancreatitis.J Biol Chem. 2018 Feb 16;293(7):2510-2522. doi: 10.1074/jbc.RA117.000792. Epub 2017 Dec 28.
136	MyD88 inhibition amplifies dendritic cell capacity to promote pancreatic carcinogenesis via Th2 cells.J Exp Med. 2012 Aug 27;209(9):1671-87. doi: 10.1084/jem.20111706. Epub 2012 Aug 20.