Details of Disease

General Information of Disease (ID: DISFTVXF)

Disease Name	Myocardial ischemia
Synonyms	ischemic heart diseases; heart disease, ischemic; ischaemic heart diseases; ischemia, myocardial; diseases, ischaemic heart; disease, ischemic heart; heart diseases, ischemic; ischemias, myocardial; diseases, ischemic heart; heart disease, ischaemic; myocardial Ischemias; disease, ischaemic heart; heart diseases, ischaemic; ischemic heart disease; myocardium ischaemic disease; ischaemic disease of myocardium; IHD; ischemic disease of myocardium; myocardium ischemic disease; ischaemic heart disease
Disease Class	BA6Z: Ischaemic heart disease
Definition	A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (coronary artery disease), to obstruction by a thrombus (coronary thrombosis), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (myocardial infarction).
Disease Hierarchy	DISRYD6K: Myocardial disease DIS5XOOY: Ischemia DISFTVXF: Myocardial ischemia
ICD Code	ICD-11 ICD-11: BA6Z ICD-10 ICD-10: I20-I25 ICD-9 ICD-9: 410, 459.89 Expand ICD-11 'BA6Z Expand ICD-10 'I20-I25 Expand ICD-9 410459.89
Disease Identifiers	MONDO ID MONDO_0024644 MESH ID D017202 UMLS CUI C0151744 MedGen ID 101801 SNOMED CT ID 414545008

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 4 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
CLBS14	DMGTUAE	Phase 2	Cell therapy	[1]
DP9	DMVKUT8	Phase 2	NA	[2]
TP10	DM5W07I	Phase 2	NA	[3]
PMID18163548C4	DMHPME3	Clinical trial	Small molecular drug	[4]
------------------------------------------------------------------------------------

This Disease is Treated as An Indication in 1 Discontinued Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
GP-531	DMGE3N3	Discontinued in Phase 2	Small molecular drug	[5]
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This Disease is Treated as An Indication in 1 Preclinical Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
BAY 60-6583	DMTEJV1	Preclinical	Small molecular drug	[6]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 197 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
ADORA1	TTK25J1	Limited	Altered Expression	[7]
AGT	TT5C0UB	Limited	Biomarker	[8]
AREG	TT76B3W	Limited	Altered Expression	[9]
CALR	TTUZ7OA	Limited	Biomarker	[10]
CD36	TTPJMCU	Limited	Biomarker	[11]
CHIT1	TTDYX6T	Limited	Altered Expression	[12]
CRK	TTFEUYR	Limited	Altered Expression	[13]
F3	TT38MDJ	Limited	Altered Expression	[14]
FGF1	TTMY81X	Limited	Biomarker	[15]
FGF2	TTGKIED	Limited	Biomarker	[16]
GDF15	TT4MXVG	Limited	Biomarker	[17]
GLP1R	TTVIMDE	Limited	Biomarker	[18]
GRK2	TTAZ3MN	Limited	Biomarker	[19]
IGFBP3	TTZHNQA	Limited	Biomarker	[15]
IL1A	TTPM6HI	Limited	Genetic Variation	[20]
LPA	TTU9LGY	Limited	Biomarker	[21]
POMC	TT21AKM	Limited	Biomarker	[22]
REN	TTB2MXP	Limited	Biomarker	[23]
SELP	TTE5VG0	Limited	Biomarker	[15]
SENP1	TTW9HY5	Limited	Biomarker	[24]
SPARC	TTBQFM7	Limited	Biomarker	[25]
TCF7L2	TT80QAL	Limited	Altered Expression	[26]
TNNI3	TTNLDK6	Limited	Altered Expression	[27]
VCAM1	TTHCEF6	Limited	Biomarker	[28]
VWF	TT3SZBT	Limited	Biomarker	[29]
ABCG1	TTMWDGU	moderate	Genetic Variation	[30]
ADORA2B	TTNE7KG	moderate	Biomarker	[31]
ALKBH5	TTOHB1M	moderate	Biomarker	[32]
ARG2	TTV1AG6	moderate	Posttranslational Modification	[33]
C5	TTKANGO	moderate	Biomarker	[34]
CYP2J2	TTNE1C7	moderate	Altered Expression	[35]
DDIT4	TTVEOY6	moderate	Biomarker	[36]
EIF5A	TTIVCNR	moderate	Altered Expression	[37]
GCLM	TTNFESW	moderate	Genetic Variation	[38]
GJA4	TTQO1VY	moderate	Genetic Variation	[39]
JAK2	TTRMX3V	moderate	Altered Expression	[40]
KCNQ3	TTIVDM3	moderate	Altered Expression	[41]
KLK4	TT4319X	moderate	Biomarker	[42]
NOD1	TTYSRXM	moderate	Biomarker	[43]
NPC1L1	TTPD1CN	moderate	Biomarker	[44]
P2RX3	TT2THBD	moderate	Biomarker	[45]
P2RY11	TTYXPCO	moderate	Biomarker	[46]
PLN	TTMCVJF	moderate	Biomarker	[47]
RAB9A	TT958S6	moderate	Genetic Variation	[48]
RGS6	TTJ96M8	moderate	Altered Expression	[49]
S100G	TTIXUDE	moderate	Biomarker	[50]
SCN9A	TT4G2JS	moderate	Altered Expression	[41]
SLC23A1	TT6XAGK	moderate	Genetic Variation	[51]
SUV39H1	TTUWQTK	moderate	Biomarker	[52]
TAGLN2	TTP6BIJ	moderate	Genetic Variation	[53]
TNNT2	TTWAS18	moderate	Biomarker	[54]
TRIP10	TTKHTGE	moderate	Biomarker	[55]
ABCC9	TTEF5MJ	Strong	Biomarker	[56]
ACE2	TTUI5H7	Strong	Biomarker	[57]
ACVR1B	TTPKHTZ	Strong	Biomarker	[58]
ADM2	TTM642F	Strong	Biomarker	[59]
ADRB1	TTR6W5O	Strong	Altered Expression	[60]
ADRB2	TTG8ZWP	Strong	Biomarker	[61]
AKR1B1	TTFBNVI	Strong	Altered Expression	[62]
ALDH2	TTFLN4T	Strong	Biomarker	[63]
ANGPT1	TTWNQ1T	Strong	Biomarker	[64]
ANXA5	TT2Z83I	Strong	Biomarker	[65]
APLN	TT87D3J	Strong	Altered Expression	[66]
APOA1	TT5S8DR	Strong	Genetic Variation	[67]
APOB	TTN1IE2	Strong	Biomarker	[21]
APOC3	TTXOZQ1	Strong	Genetic Variation	[44]
APOE	TTKS9CB	Strong	Biomarker	[68]
ASIC3	TTLGDIS	Strong	Biomarker	[69]
ASPA	TT6TLZP	Strong	Biomarker	[70]
ATP1A1	TTWK8D0	Strong	Biomarker	[15]
BAX	TTQ57WJ	Strong	Therapeutic	[71]
BDKRB2	TTGY8IW	Strong	Biomarker	[72]
C1QB	TT8A9DM	Strong	Biomarker	[15]
CACNA2D2	TTU8P3M	Strong	Biomarker	[73]
CAD	TT2YT1K	Strong	Biomarker	[74]
CCL3	TT8I4WB	Strong	Biomarker	[15]
CCND1	TTFCJ7S	Strong	Biomarker	[15]
CCR5	TTJIH8Q	Strong	Biomarker	[75]
CD38	TTPURFN	Strong	Biomarker	[15]
CD40	TT1ERKL	Strong	Therapeutic	[76]
CD40LG	TTIJP3Q	Strong	Biomarker	[77]
CDH2	TT1WS0T	Strong	Biomarker	[15]
CPT1B	TTDL0NY	Strong	Biomarker	[15]
CRYAB	TT7RUHB	Strong	Biomarker	[78]
CS	TTZA6B3	Strong	Altered Expression	[79]
CTSC	TT4H0V2	Strong	Biomarker	[15]
CX3CL1	TT1OFBQ	Strong	Biomarker	[15]
CXCL2	TTZF0K2	Strong	Biomarker	[15]
CYP2D6	TTVG215	Strong	Genetic Variation	[80]
CYSLTR1	TTGKOY9	Strong	Biomarker	[81]
DCN	TTB3XAN	Strong	Biomarker	[15]
DLL4	TTV23LH	Strong	Biomarker	[82]
DPP4	TTDIGC1	Strong	Genetic Variation	[83]
DUSP1	TTG8HIM	Strong	Biomarker	[15]
EDN1	TTJR60Z	Strong	Biomarker	[84]
EDNRB	TT3ZTGU	Strong	Altered Expression	[85]
EIF2AK3	TT79U1M	Strong	Biomarker	[86]
EIF2AK4	TT9U4EP	Strong	Altered Expression	[87]
EIF4E	TTZGCP6	Strong	Biomarker	[88]
EIF4EBP1	TTKGEBL	Strong	Biomarker	[88]
ENSA	TTQD0YT	Strong	Biomarker	[15]
EPHX2	TT7WVHI	Strong	Biomarker	[89]
F2	TT6L509	Strong	Genetic Variation	[90]
F2RL1	TTQR74A	Strong	Biomarker	[15]
F5	TT1O264	Strong	Genetic Variation	[90]
FABP3	TT3TGLR	Strong	Genetic Variation	[91]
FABP5	TTNT2S6	Strong	Biomarker	[15]
FDPS	TTIKWV4	Strong	Biomarker	[92]
FGF4	TTCEKVZ	Strong	Biomarker	[93]
GCH1	TTLSWP6	Strong	Biomarker	[15]
GHR	TTHJWYD	Strong	Biomarker	[15]
GHRL	TT1OCL0	Strong	ModifyingMutation	[94]
GHSR	TTWDC17	Strong	Biomarker	[94]
GLO1	TTV9A7R	Strong	Altered Expression	[95]
GSTA1	TT4P8DE	Strong	Biomarker	[15]
GSTP1	TT40K12	Strong	Biomarker	[15]
HBA2	TTQO71U	Strong	Biomarker	[96]
HGF	TT4V2JM	Strong	Biomarker	[97]
HK2	TTK02H8	Strong	Biomarker	[15]
HMGCS2	TTS0EZJ	Strong	Biomarker	[15]
HMOX1	TTI6V2A	Strong	Biomarker	[98]
HSD17B13	TTDJYZR	Strong	Genetic Variation	[99]
HSPA9	TTMTPG3	Strong	Biomarker	[15]
HSPD1	TT9HL5R	Strong	Biomarker	[100]
ID1	TTBXVDE	Strong	Biomarker	[15]
IGF1	TTT6LOU	Strong	Genetic Variation	[101]
IRF1	TT4TU3L	Strong	Biomarker	[15]
KCNJ11	TT329V4	Strong	Biomarker	[102]
KDR	TTUTJGQ	Strong	Biomarker	[15]
KITLG	TTDJ51N	Strong	Biomarker	[15]
KLF4	TTTI53X	Strong	Biomarker	[15]
KLK1	TT5T3P6	Strong	Biomarker	[103]
LCT	TTA0OSE	Strong	Genetic Variation	[104]
LDLR	TTH0DUS	Strong	Biomarker	[105]
LOX	TTQHNAM	Strong	Biomarker	[106]
LPL	TTOF3WZ	Strong	Genetic Variation	[107]
LTC4S	TTW7OTG	Strong	Genetic Variation	[108]
MANF	TT56RYE	Strong	Biomarker	[109]
MAP3K8	TTGECUM	Strong	Biomarker	[15]
MAPK10	TT056SO	Strong	Genetic Variation	[99]
MAPK14	TTQBR95	Strong	Biomarker	[110]
MBL2	TTMQDZ5	Strong	Biomarker	[111]
MCM6	TTQGKSD	Strong	Genetic Variation	[112]
MTTP	TTUS1RD	Strong	Genetic Variation	[44]
NCL	TTK1V5Q	Strong	Biomarker	[15]
NEDD4	TT1QU6G	Strong	Biomarker	[15]
NFKBIA	TTSHAEB	Strong	Biomarker	[15]
NOS3	TTCM4B3	Strong	Genetic Variation	[113]
NPPB	TTY63XT	Strong	Biomarker	[114]
NPR1	TTM9IYA	Strong	Biomarker	[115]
NR4A1	TTMXE2Q	Strong	Biomarker	[15]
OLR1	TTKSND3	Strong	Biomarker	[11]
OPA1	TTTU49Q	Strong	Therapeutic	[116]
PCSK9	TTNIZ2B	Strong	Biomarker	[117]
PDE4B	TTVIAT9	Strong	Biomarker	[15]
PEBP1	TT1BGU8	Strong	Biomarker	[15]
PFKFB3	TTTHMQJ	Strong	Biomarker	[15]
PLA2G2A	TTO8QRU	Strong	Biomarker	[15]
PLA2G7	TTDNFMT	Strong	Biomarker	[118]
PNPLA3	TTEUAEH	Strong	Genetic Variation	[119]
PPAT	TTZFTY4	Strong	Biomarker	[15]
PPID	TTNAFOU	Strong	Biomarker	[120]
PPIF	TTRFQTB	Strong	Biomarker	[120]
PPP2CA	TTHTKNY	Strong	Biomarker	[15]
PRKCD	TT7A1BO	Strong	Biomarker	[121]
PRKCE	TT57MT2	Strong	Biomarker	[15]
PSMB5	TT68GPI	Strong	Biomarker	[15]
PYGM	TTZHY6R	Strong	Biomarker	[122]
RAB7A	TTF6WAQ	Strong	Biomarker	[15]
RALBP1	TTVSRUA	Strong	Biomarker	[15]
RXRG	TTH029C	Strong	Biomarker	[15]
SAA1	TTY0DN9	Strong	Genetic Variation	[123]
SCN5A	TTZOVE0	Strong	Altered Expression	[26]
SELE	TT1PL7M	Strong	Biomarker	[15]
SFRP4	TTX8I1Y	Strong	Biomarker	[124]
SFTPD	TTGLMU7	Strong	Biomarker	[125]
SLC22A6	TTTYH7A	Strong	Biomarker	[126]
SLC22A8	TTTQR47	Strong	Biomarker	[126]
SLC29A1	TTLXAKE	Strong	Biomarker	[127]
SLC33A1	TTL69WB	Strong	Biomarker	[103]
SLC5A1	TT2UE56	Strong	Biomarker	[128]
SLC5A2	TTF8JAT	Strong	Biomarker	[129]
SLC8A1	TTCF82X	Strong	Biomarker	[15]
SLC9A1	TTGSEFH	Strong	Altered Expression	[130]
SOCS3	TTI0ME6	Strong	Biomarker	[15]
TAP1	TT7JZI8	Strong	Biomarker	[15]
TFRC	TT8MG4S	Strong	Biomarker	[15]
TMSB4X	TTMVAIU	Strong	Biomarker	[131]
TNF	TTF8CQI	Strong	Biomarker	[132]
TXN	TTZJ5U9	Strong	Biomarker	[133]
TXNIP	TTTLDZK	Strong	Biomarker	[134]
TXNRD1	TTR7UJ3	Strong	Biomarker	[15]
UGCG	TTPHEX3	Strong	Biomarker	[15]
UTS2R	TTW5UDX	Strong	Altered Expression	[135]
VEGFB	TTPJQHE	Strong	Biomarker	[136]
ZNF202	TTD9R62	Strong	Genetic Variation	[137]
HMGB1	TTWQYB7	Definitive	Biomarker	[138]
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⏷ Show the Full List of 197 DTT(s)

This Disease Is Related to 3 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
ATP2B1	DTJWQ1L	Strong	Genetic Variation	[139]
KCNK2	DTENHUP	Strong	Biomarker	[140]
SLC6A6	DTHWCVA	Strong	Biomarker	[15]
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This Disease Is Related to 14 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
EPHX1	DELB4KP	Limited	Biomarker	[89]
GCLC	DESYL1F	Limited	Genetic Variation	[38]
SULT1A1	DEYWLRK	Limited	Biomarker	[55]
CYP2R1	DEBIHM3	moderate	Genetic Variation	[141]
MSRA	DEU2ZBY	moderate	Genetic Variation	[142]
ACOT2	DEMEPVJ	Strong	Biomarker	[15]
ADH1C	DEM1HNL	Strong	Genetic Variation	[143]
APRT	DE2MV1R	Strong	Altered Expression	[144]
CES3	DEMI4VE	Strong	Biomarker	[15]
DDAH1	DEY0TQC	Strong	Biomarker	[145]
HK1	DEDMAGE	Strong	Biomarker	[15]
PCYT1A	DEQYXD4	Strong	Biomarker	[146]
PGM1	DEA3VM1	Strong	Biomarker	[15]
UGT1A6	DESD26P	Strong	Genetic Variation	[147]
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⏷ Show the Full List of 14 DME(s)

This Disease Is Related to 182 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ABRAXAS2	OTAW1I4C	Limited	Altered Expression	[148]
AXIN2	OTRMGQNU	Limited	Biomarker	[149]
CCL4	OT6B8P25	Limited	Genetic Variation	[150]
CIRBP	OTXWTPBL	Limited	Biomarker	[151]
ELN	OTFSO7PG	Limited	Biomarker	[15]
IRF2BP2	OTSSRRCA	Limited	Altered Expression	[152]
ITLN1	OT7ZLJVV	Limited	Altered Expression	[153]
NPPA	OTMQNTNX	Limited	Genetic Variation	[154]
PER2	OTU2B1DJ	Limited	Biomarker	[155]
TTN	OT0LZ058	Limited	Biomarker	[156]
AIRE	OTA7G1Y1	moderate	Biomarker	[157]
AMIGO2	OTPAIT1O	moderate	Biomarker	[158]
BTBD8	OT3A3RD7	moderate	Biomarker	[159]
CCL4L2	OTDBSXOU	moderate	Genetic Variation	[150]
CERS1	OT6EYRM3	moderate	Genetic Variation	[150]
CHD9	OTWNFDKJ	moderate	Biomarker	[160]
CLEC7A	OTRTBH27	moderate	Biomarker	[161]
CREG1	OTRHJ8HK	moderate	Biomarker	[162]
CYGB	OTX153DQ	moderate	Biomarker	[163]
DESI1	OTFNIW98	moderate	Biomarker	[164]
DIAPH1	OTZBYPLH	moderate	Biomarker	[165]
EEF2	OTZ7SZ39	moderate	Biomarker	[166]
ENDOG	OT5IM7B3	moderate	Biomarker	[167]
ETV7	OTIAADPA	moderate	Biomarker	[168]
FUNDC1	OTA6IVKQ	moderate	Biomarker	[169]
GDF1	OTZ1VRBH	moderate	Genetic Variation	[150]
GGPS1	OTVEHG28	moderate	Biomarker	[170]
GNLY	OTZJKA8C	moderate	Biomarker	[171]
HBA1	OTW2BQF4	moderate	Altered Expression	[172]
HECTD1	OTJ95JJS	moderate	Biomarker	[173]
JAZF1	OTXTYSYD	moderate	Altered Expression	[174]
KLF10	OT4F4UGS	moderate	Biomarker	[175]
KLF15	OTGMQMVR	moderate	Biomarker	[176]
MCF2L2	OTOGFMIH	moderate	Biomarker	[177]
MCU	OTQZAYWQ	moderate	Biomarker	[178]
MSX2	OT1WDKE1	moderate	Biomarker	[22]
MYOM1	OTWALWGY	moderate	Altered Expression	[179]
NUDT1	OTZSES3W	moderate	Genetic Variation	[180]
OXCT1	OT536PE7	moderate	Genetic Variation	[181]
PAPPA	OTTTG9PG	moderate	Genetic Variation	[182]
PHLPP1	OTIFXW8D	moderate	Altered Expression	[183]
PIAS1	OTZVAHZI	moderate	Biomarker	[184]
PLIN5	OTV8G50L	moderate	Biomarker	[185]
POC1A	OTXAG4PL	moderate	Genetic Variation	[186]
PPAN	OT0UFQBZ	moderate	Biomarker	[46]
RCAN1	OT1MVXC7	moderate	Altered Expression	[187]
SENP3	OTFQDOMC	moderate	Biomarker	[188]
SIRT7	OT5M4OT4	moderate	Biomarker	[189]
SLC35G1	OTKZUA8O	moderate	Biomarker	[164]
SOSTDC1	OTAKDNSM	moderate	Biomarker	[190]
SRXN1	OTYDBO4L	moderate	Biomarker	[191]
STX1A	OTSBUZB4	moderate	Genetic Variation	[192]
TAB1	OTPM6F85	moderate	Genetic Variation	[110]
TELO2	OT2YQ9L8	moderate	Biomarker	[168]
TMIGD2	OTWWAHTV	moderate	Biomarker	[193]
TRAF1	OTTLM5RU	moderate	Biomarker	[194]
TRAF3IP2	OTLLZERL	moderate	Biomarker	[195]
A1CF	OTJBKFA1	Strong	Biomarker	[70]
ACTB	OT1MCP2F	Strong	Biomarker	[15]
AGXT2	OTO6QUTM	Strong	Biomarker	[145]
AK1	OT614AR3	Strong	Biomarker	[15]
ALDH6A1	OT8LCZCT	Strong	Biomarker	[15]
ALDOA	OTWRFTIB	Strong	Biomarker	[15]
AMPD1	OTU17BCI	Strong	Genetic Variation	[196]
APLP2	OTTFE53M	Strong	Biomarker	[15]
APOA5	OTEVKLVA	Strong	Genetic Variation	[197]
ARC	OTN2QQPG	Strong	Altered Expression	[198]
ATP5PF	OTDAE8FP	Strong	Genetic Variation	[199]
BHLHE40	OTITX14U	Strong	Biomarker	[15]
CAMK2D	OTJ5XLVU	Strong	Biomarker	[15]
CANX	OTYP1F6J	Strong	Biomarker	[15]
CCND2	OTDULQF9	Strong	Biomarker	[15]
CEBPD	OTNBIPMY	Strong	Biomarker	[15]
CLEC10A	OTD8HQT6	Strong	Biomarker	[15]
COL5A2	OT5VOSQE	Strong	Biomarker	[200]
COX4I1	OTU0FC24	Strong	Altered Expression	[79]
COX4I2	OTB98B21	Strong	Altered Expression	[79]
COX5B	OTDP94F3	Strong	Biomarker	[15]
CSN2	OT22C0PD	Strong	Biomarker	[201]
CTTNBP2	OT4CL1EW	Strong	Biomarker	[15]
DLAT	OT9LBJVN	Strong	Biomarker	[15]
DNM1L	OTXK1Q1G	Strong	Biomarker	[15]
DUSP6	OT4H6RKW	Strong	Biomarker	[15]
EDIL3	OTDVVNS0	Strong	Biomarker	[202]
EGR2	OTAVQ78J	Strong	Biomarker	[15]
EIF2A	OTWXELQP	Strong	Biomarker	[86]
EIF4G1	OT2CF1E6	Strong	Biomarker	[88]
EPRS1	OTXK0FLB	Strong	Biomarker	[203]
FEV	OTYEC4IR	Strong	Biomarker	[15]
FEZ2	OTAFCKAX	Strong	Biomarker	[15]
FGB	OT6RKLI9	Strong	Genetic Variation	[204]
FXYD1	OTNKT6GP	Strong	Altered Expression	[205]
GATM	OTIJ4Z11	Strong	Biomarker	[15]
GBP2	OTVU4G07	Strong	Biomarker	[15]
GCKR	OTSIWXGG	Strong	Genetic Variation	[206]
GDF10	OTEVXGJ7	Strong	Genetic Variation	[207]
GK	OTK2YRA0	Strong	Biomarker	[15]
GMFG	OTMPNSE7	Strong	Altered Expression	[208]
GNA12	OT3IRZH3	Strong	Biomarker	[15]
GPLD1	OTUUQOVY	Strong	Biomarker	[209]
GSTM2	OTG4WT05	Strong	Biomarker	[15]
GYG1	OT9PU6I2	Strong	Biomarker	[15]
HADHA	OTO557N2	Strong	Biomarker	[15]
HIVEP2	OTVOMCW4	Strong	Biomarker	[15]
HLA-E	OTX1CTFB	Strong	Biomarker	[15]
HSPA1A	OTKGIE76	Strong	Biomarker	[15]
HSPA2	OTSDET7B	Strong	Biomarker	[15]
HSPB6	OTFPLGZI	Strong	Posttranslational Modification	[210]
ID3	OTUULW5Z	Strong	Biomarker	[15]
IFNGR1	OTCTQBWW	Strong	Biomarker	[15]
IFRD1	OT4SQMLQ	Strong	Genetic Variation	[211]
IL18BP	OTW0LRYZ	Strong	Altered Expression	[212]
IL6ST	OT1N9C70	Strong	Altered Expression	[213]
JUNB	OTG2JXV5	Strong	Biomarker	[15]
KCNJ8	OTZ8G8FE	Strong	Biomarker	[102]
LIPC	OTZY5SC9	Strong	Genetic Variation	[214]
MAP1LC3B	OTUYHB84	Strong	Biomarker	[215]
MAP2K3	OTI2OREX	Strong	Biomarker	[216]
MAPRE1	OTCVQD60	Strong	Biomarker	[15]
MB	OTYWYL2D	Strong	Biomarker	[217]
MED23	OTKZQT0R	Strong	Genetic Variation	[145]
MEF2A	OTV2SF6E	Strong	Genetic Variation	[218]
MEOX2	OTKZCJCB	Strong	Biomarker	[15]
MFAP1	OTZN4FT3	Strong	Altered Expression	[144]
MFN1	OTCBXQZF	Strong	Therapeutic	[116]
MFN2	OTPYN8A3	Strong	Altered Expression	[79]
MPI	OTBH6ZK1	Strong	Biomarker	[219]
MRTFA	OTCVXASM	Strong	Biomarker	[220]
MSN	OTZJ4J6G	Strong	Biomarker	[15]
MX1	OT6X8G5T	Strong	Biomarker	[15]
NGB	OTW0SIUY	Strong	Altered Expression	[221]
NMU	OTW9X7BQ	Strong	Altered Expression	[222]
NPHS2	OTLCNUII	Strong	Genetic Variation	[223]
NPTN	OTAQKSAU	Strong	Biomarker	[15]
P4HB	OTTYNYPF	Strong	Biomarker	[15]
PADI2	OTT40K94	Strong	Biomarker	[224]
PDHA1	OTGEU8IK	Strong	Biomarker	[15]
PDK4	OTCMHMBZ	Strong	Biomarker	[15]
PDLIM5	OTLQVV22	Strong	Biomarker	[15]
PENK	OT8P3HMP	Strong	Therapeutic	[225]
PFKM	OT1QY9JM	Strong	Biomarker	[15]
PLCD1	OT6WFVXZ	Strong	Biomarker	[226]
PPM1B	OTZMH6V3	Strong	Biomarker	[15]
PPP1R15A	OTYG179K	Strong	Altered Expression	[227]
PPP3R1	OTGQNFJQ	Strong	Biomarker	[15]
PRDX6	OTS8KC8A	Strong	Biomarker	[15]
PRSS23	OT6DQAM1	Strong	Biomarker	[228]
PTPRA	OTZA82J1	Strong	Biomarker	[15]
PYGB	OT2ZTJT0	Strong	Biomarker	[15]
RAB12	OTM84KTU	Strong	Biomarker	[15]
RAB1B	OTAFCUAS	Strong	Biomarker	[15]
RAB5A	OTFR2KM4	Strong	Biomarker	[15]
RAMP2	OTGQXLH5	Strong	Biomarker	[59]
RELB	OTU3QYEF	Strong	Biomarker	[229]
RGCC	OTYJMLWM	Strong	Biomarker	[15]
RHOC	OTOLE1FT	Strong	Biomarker	[15]
RLN2	OTY3OG71	Strong	Biomarker	[230]
RLN3	OTQSQMUQ	Strong	Therapeutic	[231]
ROPN1L	OTRWZJ68	Strong	Biomarker	[70]
RPL17	OTTYMPS6	Strong	Biomarker	[15]
RSAD2	OTCA9WCM	Strong	Biomarker	[15]
RTN1	OTCX1SMK	Strong	Biomarker	[15]
RYR2	OT0PF19E	Strong	Biomarker	[15]
SAA2	OTYAVJWG	Strong	Genetic Variation	[123]
SAMM50	OTRYFYIU	Strong	Genetic Variation	[99]
SCG2	OTXWUQQL	Strong	Biomarker	[232]
SIRT4	OT5S0J23	Strong	Altered Expression	[233]
SLN	OTERIU75	Strong	Altered Expression	[234]
SNAP23	OTY2MYBX	Strong	Biomarker	[15]
SOD3	OTIOZQAB	Strong	Genetic Variation	[235]
STAT5A	OTBSJGN3	Strong	Biomarker	[236]
TAB3	OT1ECMDL	Strong	Biomarker	[237]
TCP1	OT1MGUX9	Strong	Biomarker	[146]
TEAD1	OTK6971C	Strong	Altered Expression	[238]
TFEB	OTJUJJQY	Strong	Biomarker	[239]
TLE4	OT4QEH6T	Strong	Biomarker	[15]
TLE5	OTEH0BFG	Strong	Biomarker	[15]
TMED2	OTBLO7RW	Strong	Biomarker	[15]
TMPO	OTL68EL4	Strong	Biomarker	[15]
TRIB1	OTPEO17G	Strong	Genetic Variation	[206]
TRIM63	OTUSWA74	Strong	Altered Expression	[240]
ND2	OTG9OHOX	Definitive	Genetic Variation	[241]
------------------------------------------------------------------------------------


⏷ Show the Full List of 182 DOT(s)

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86	Aldose reductase decreases endoplasmic reticulum stress in ischemic hearts. Chem Biol Interact. 2009 Mar 16;178(1-3):242-9. doi: 10.1016/j.cbi.2008.10.055. Epub 2008 Nov 11.
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91	Usefulness of Heart-Type Fatty Acid-Binding Protein and Myocardial Performance Index for Early Detection of 5-Fluorouracil Cardiotoxicity.Angiology. 2017 Jan;68(1):52-58. doi: 10.1177/0003319716637516. Epub 2016 Mar 15.
92	Overexpression of farnesyl pyrophosphate synthase increases myocardial ischemia/reperfusion injury in mice.Gene. 2018 Sep 25;672:72-78. doi: 10.1016/j.gene.2018.05.116. Epub 2018 Jun 1.
93	Therapeutics targeting angiogenesis: genetics and epigenetics, extracellular miRNAs and signaling networks (Review).Int J Mol Med. 2013 Oct;32(4):763-7. doi: 10.3892/ijmm.2013.1444. Epub 2013 Jul 16.
94	Cardioprotective effects of ghrelin and des-octanoyl ghrelin on myocardial injury induced by isoproterenol in rats.Acta Pharmacol Sin. 2006 May;27(5):527-35. doi: 10.1111/j.1745-7254.2006.00319.x.
95	Glyoxalase 1 Prevents Chronic Hyperglycemia Induced Heart-Explant Derived Cell Dysfunction.Theranostics. 2019 Aug 9;9(19):5720-5730. doi: 10.7150/thno.36639. eCollection 2019.
96	Hemoglobins emerging roles in mental disorders. Metabolical, genetical and immunological aspects.Int J Dev Neurosci. 2017 Oct;61:73-85. doi: 10.1016/j.ijdevneu.2017.06.007. Epub 2017 Jul 8.
97	Establishment of a lentiviral vector encoding human HGF and the infection of human ADSCs.Biomed Res Int. 2013;2013:724896. doi: 10.1155/2013/724896. Epub 2013 Jan 20.
98	Hyperglycemia in streptozotocin-induced diabetic rat increases infarct size associated with low levels of myocardial HO-1 during ischemia/reperfusion.Diabetes. 2005 Mar;54(3):803-10. doi: 10.2337/diabetes.54.3.803.
99	Mendelian randomization estimates of alanine aminotransferase with cardiovascular disease: Guangzhou Biobank Cohort study.Hum Mol Genet. 2017 Jan 15;26(2):430-437. doi: 10.1093/hmg/ddw396.
100	Proteomic analysis of rat heart in ischemia and ischemia-reperfusion using fluorescence two-dimensional difference gel electrophoresis.Proteomics. 2003 Jul;3(7):1318-24. doi: 10.1002/pmic.200300432.
101	Case report: low circulating IGF-I levels due to Acid-Labile Subunit deficiency in adulthood are not associated with early development of atherosclerosis and impaired heart function.Growth Horm IGF Res. 2011 Aug;21(4):233-7. doi: 10.1016/j.ghir.2011.05.004. Epub 2011 Jun 12.
102	Effect of electronic stimulation at Neiguan (PC 6) acupoint on gene expression of adenosine triphosphate-sensitive potassium channel and protein kinases in rats with myocardial ischemia.J Tradit Chin Med. 2015 Oct;35(5):577-82. doi: 10.1016/s0254-6272(15)30142-4.
103	Pathophysiology of genetic deficiency in tissue kallikrein activity in mouse and man.Thromb Haemost. 2013 Sep;110(3):476-83. doi: 10.1160/TH12-12-0937. Epub 2013 Apr 4.
104	Milk intake is not associated with ischaemic heart disease in observational or Mendelian randomization analyses in 98,529 Danish adults.Int J Epidemiol. 2015 Apr;44(2):587-603. doi: 10.1093/ije/dyv109.
105	Scavenger Receptor Class B Type 1 Deletion Led to Coronary Atherosclerosis and Ischemic Heart Disease in Low-density Lipoprotein Receptor Knockout Mice on Modified Western-type Diet.J Atheroscler Thromb. 2017 Feb 1;24(2):133-146. doi: 10.5551/jat.33019. Epub 2016 Jul 2.
106	Differential regulation of functional gene clusters in overt coronary artery disease in a transgenic atherosclerosis-hypertensive rat model.Mol Med. 2002 Jul;8(7):367-75.
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