General Information of Disease (ID: DISQKVLA)

Disease Name Pulmonary fibrosis
Synonyms pulmonary interstitial fibrosis; fibrosis of lung
Disease Class CB03: Idiopathic interstitial pneumonitis
Definition
Chronic progressive interstitial lung disorder characterized by the replacement of the lung tissue by connective tissue, leading to progressive dyspnea, respiratory failure, or right heart failure. Causes include chronic inflammatory processes, exposure to environmental irritants, radiation therapy, autoimmune disorders, certain drugs, or it may be idiopathic (no identifiable cause).
Disease Hierarchy
DISWSHC6: Interstitial lung disease
DISQKVLA: Pulmonary fibrosis
ICD Code
ICD-11
ICD-11: CB03.4
ICD-10
ICD-10: J84.1
Expand ICD-11
'CB03.4
Expand ICD-10
'J84.1
Expand ICD-9
515516.3
Disease Identifiers
MONDO ID
MONDO_0002771
MESH ID
D011658
UMLS CUI
C0034069
MedGen ID
11028
HPO ID
HP:0002206
SNOMED CT ID
51615001

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 1 Approved Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Dichloroacetate DMZ5Y1P Phase 4 Small molecular drug [1]
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This Disease is Treated as An Indication in 5 Clinical Trial Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
BMS-986278 DMD27RW Phase 2 Small molecule [2]
Carlumab DMAUN15 Phase 2 Antibody [3]
SAR-156597 DMUICJD Phase 2 Antibody [4]
BI 1839100 DMTT0P9 Phase 1 NA [5]
BMS-986337 DM9GC6L Phase 1 Small molecule [6]
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This Disease is Treated as An Indication in 7 Preclinical Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
CA-074Me DMVN3FU Preclinical Small molecular drug [7]
Ciglitazone DMAPO0T Preclinical Small molecular drug [8]
CWHM-12 DM8YUJT Preclinical Small molecular drug [9]
P-007 DMKGMK6 Preclinical Antibody [10]
PIRINIXIC ACID DM82Y75 Preclinical Small molecular drug [8]
SB-431542 DM0YOXQ Preclinical Small molecular drug [7]
Z-VAD-fmk DMTDG7L Preclinical Small molecular drug [7]
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⏷ Show the Full List of 7 Drug(s)
This Disease is Treated as An Indication in 6 Investigative Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
3PO DMPF5OX Investigative Small molecular drug [11]
DasKloster 0028-01 DMSZRCN Investigative NA [12]
GRN-510 DMTYWKC Investigative NA [12]
NCX-226 DMJ9HHX Investigative NA [12]
PTL-101 DMAEL4C Investigative NA [13]
SD-560 DMNUJX5 Investigative NA [12]
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⏷ Show the Full List of 6 Drug(s)

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 200 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
CAT TTPS279 Limited Altered Expression [14]
CAV1 TTXUBN2 Limited Biomarker [15]
CCL5 TT9DWLC Limited Biomarker [16]
CEBPB TTUI35N Limited Biomarker [17]
CFTR TTRLZHP Limited Genetic Variation [18]
CTLA4 TTI2S1D Limited Biomarker [19]
EGF TTED8JB Limited Biomarker [20]
FASLG TTO7014 Limited Altered Expression [21]
FGF1 TTMY81X Limited Biomarker [22]
HMOX1 TTI6V2A Limited Biomarker [23]
IL17A TTG0MT6 Limited Biomarker [24]
IL6 TTT1V78 Limited Biomarker [25]
IRAK1 TTXAJWN Limited Biomarker [26]
MECP2 TTTAU9R Limited Biomarker [27]
PRKCD TT7A1BO Limited Biomarker [28]
PRTN3 TT5MLC4 Limited Biomarker [29]
STAT6 TTWOE1T Limited Biomarker [30]
TGFB3 TTWOMY8 Limited Genetic Variation [31]
UTRN TTNO1VA Limited Biomarker [32]
ADORA2B TTNE7KG moderate Altered Expression [33]
AGER TTMO9HF moderate Biomarker [34]
ATF3 TTCE793 moderate Altered Expression [35]
BACH1 TT2ME4S moderate Altered Expression [36]
CCR3 TTD3XFU moderate Biomarker [37]
CCR4 TT7HQD0 moderate Biomarker [38]
CCR8 TTE836A moderate Biomarker [38]
CDH11 TTRGWZC moderate Biomarker [39]
CNR2 TTMSFAW moderate Biomarker [40]
CSF1 TT0IQER moderate Biomarker [41]
CSF3 TT5TQ2W moderate Biomarker [42]
FGF2 TTGKIED moderate Altered Expression [43]
FN1 TTPJ921 moderate Altered Expression [44]
FOLR2 TTT54CI moderate Altered Expression [45]
FST TTDNM9W moderate Biomarker [46]
GLRX TTRJCNG moderate Biomarker [47]
HDAC8 TTT6LFV moderate Biomarker [48]
IL1RN TT6GSR3 moderate Genetic Variation [49]
IL5 TTPREZD moderate Biomarker [16]
ITGB6 TTKQSXZ moderate Altered Expression [50]
LDHA TTW76JE moderate Biomarker [51]
LTB4R TTN53ZF moderate Biomarker [52]
MAPK7 TTU6FSC moderate Biomarker [53]
MAPKAPK2 TTMUG9D moderate Biomarker [54]
MMP7 TTMTWOS moderate Biomarker [55]
MTOR TTCJG29 moderate Biomarker [56]
NLRP1 TTQX29T moderate Altered Expression [57]
NOX4 TTQRBSJ moderate Biomarker [58]
OSM TTIVXSE moderate Biomarker [59]
PARP1 TTVDSZ0 moderate Biomarker [60]
PDGFA TTSM78N moderate Biomarker [61]
PF4 TTSG7Q5 moderate Biomarker [62]
PTPRC TTUS45N moderate Altered Expression [63]
ROCK2 TTGWKQJ moderate Altered Expression [64]
SDC2 TT5H2F0 moderate Altered Expression [65]
SERPINB3 TT6QLPX moderate Biomarker [66]
SIRT6 TTUXYWF moderate Biomarker [67]
SMAD7 TT0J32Z moderate Biomarker [68]
SSRP1 TTETDKQ moderate Biomarker [34]
TFF1 TTNOJIZ moderate Genetic Variation [69]
THBD TTAPV67 moderate Biomarker [70]
TNF TTF8CQI moderate Biomarker [71]
TNFSF14 TTKVENM moderate Biomarker [72]
ABCG1 TTMWDGU Strong Biomarker [73]
ACE2 TTUI5H7 Strong Altered Expression [74]
ACO2 TTMTF2P Strong Biomarker [75]
ADAM33 TTQICM2 Strong Biomarker [76]
ADIPOQ TTXKA7D Strong Therapeutic [77]
AGT TT5C0UB Strong Biomarker [78]
ANGPT1 TTWNQ1T Strong Biomarker [79]
ANXA1 TTUCK4B Strong Biomarker [80]
AOC3 TT7HC21 Strong Altered Expression [81]
AREG TT76B3W Strong Biomarker [82]
BMP7 TTKOBRA Strong Biomarker [83]
BMPR2 TTGKF90 Strong Altered Expression [84]
C3AR1 TTI6B3F Strong Biomarker [85]
CALCA TTVSFJW Strong Biomarker [86]
CCL11 TTCF05Y Strong Altered Expression [87]
CCL17 TTMPHAE Strong Biomarker [38]
CCL22 TTBTWI1 Strong Altered Expression [88]
CCL3 TT8I4WB Strong Biomarker [89]
CD36 TTPJMCU Strong Biomarker [90]
CDH5 TTXLCFO Strong Altered Expression [91]
CEBPA TT5LWG1 Strong Therapeutic [92]
CFD TT8D13I Strong Biomarker [93]
CHAT TTKYFSB Strong Biomarker [94]
CHIT1 TTDYX6T Strong Altered Expression [95]
CHST15 TTFK7E1 Strong Biomarker [96]
CMA1 TT8VUE0 Strong Biomarker [97]
COL1A2 TTUABC1 Strong Genetic Variation [98]
CRLF1 TT6YF5K Strong Biomarker [99]
CSF2 TTNYZG2 Strong Biomarker [100]
CSNK1D TTH30UI Strong Biomarker [101]
CXCL2 TTZF0K2 Strong Biomarker [102]
CXCR4 TTBID49 Strong Biomarker [103]
CYSLTR1 TTGKOY9 Strong Biomarker [104]
CYSLTR2 TT0PZR5 Strong Biomarker [105]
DDR2 TTU98HG Strong Biomarker [106]
DEPTOR TTLYP6D Strong Altered Expression [107]
DUSP10 TTF3RJ0 Strong Biomarker [108]
ECE1 TTQ9RYT Strong Biomarker [109]
EDN1 TTJR60Z Strong Altered Expression [110]
ELANE TTPLTSQ Strong Biomarker [111]
F2R TTL935N Strong Biomarker [112]
F2RL1 TTQR74A Strong Biomarker [113]
F2RL2 TTVSEBF Strong Biomarker [114]
FGF7 TTFY134 Strong Biomarker [115]
FKBP10 TT4P8O2 Strong Altered Expression [116]
FOSL2 TT689IR Strong Altered Expression [117]
FURIN TTH9WF6 Strong Biomarker [118]
FYN TT2B9KF Strong Biomarker [119]
FZD7 TTUQMO5 Strong Biomarker [120]
GAS6 TT69QD2 Strong Biomarker [121]
GLI1 TTJOMH6 Strong Biomarker [122]
GREM1 TTOUZN5 Strong Genetic Variation [123]
GRHL2 TTUGH4C Strong Biomarker [124]
HGF TT4V2JM Strong Altered Expression [125]
HSP90AB1 TTH5YN2 Strong Biomarker [126]
HSPB3 TTLH8WG Strong Altered Expression [127]
HSPD1 TT9HL5R Strong Biomarker [128]
ICAM1 TTA1L39 Strong Biomarker [129]
IGF1 TTT6LOU Strong Altered Expression [130]
IL11RA TTZPLJS Strong Biomarker [131]
IL12B TTGW72V Strong Biomarker [132]
IL13 TT0GVCH Strong Altered Expression [133]
IL1A TTPM6HI Strong Biomarker [134]
IL1RL1 TT4GZA4 Strong Biomarker [135]
IL33 TT5MD4P Strong Biomarker [136]
IL4 TTLGTKB Strong Altered Expression [137]
INPP5D TTTP2Z1 Strong Biomarker [138]
ITGA6 TT165T3 Strong Biomarker [139]
ITGAE TTH0Z37 Strong Biomarker [140]
KLF4 TTTI53X Strong Biomarker [141]
LILRB1 TTC0QRJ Strong Altered Expression [142]
LOX TTQHNAM Strong Biomarker [143]
LOXL2 TTFSUHX Strong Biomarker [144]
LTBR TTFO0PM Strong Biomarker [145]
MAP3K11 TTETX6Q Strong Biomarker [146]
MARCKS TTHRM39 Strong Biomarker [147]
MARK2 TTAJ45Y Strong Altered Expression [113]
METAP2 TTZL0OI Strong Biomarker [148]
MMP1 TTMX39J Strong Genetic Variation [149]
MMP2 TTLM12X Strong Altered Expression [150]
MSR1 TT2TDH9 Strong Biomarker [151]
MUC5AC TTEL90S Strong Biomarker [152]
NEDD8 TTNDC4K Strong Altered Expression [153]
NFE2L2 TTA6ZN2 Strong Biomarker [154]
NLRP3 TT4EN8X Strong Altered Expression [155]
NT5E TTK0O6Y Strong Biomarker [156]
P2RX1 TTJW7B3 Strong Biomarker [157]
P2RX3 TT2THBD Strong Biomarker [157]
P2RX4 TT1NLOA Strong Biomarker [157]
PDE1A TT73TEJ Strong Altered Expression [158]
PDGFB TTQA6SX Strong Biomarker [159]
PDGFRA TT8FYO9 Strong Biomarker [160]
PLAU TTGY7WI Strong Altered Expression [161]
PLG TTP86E2 Strong Biomarker [162]
POSTN TT8ALTZ Strong Biomarker [163]
PTPN13 TT405FP Strong Altered Expression [164]
PTPRJ TTWMKXP Strong Biomarker [65]
RAPGEF3 TTOE7I0 Strong Biomarker [109]
RGS2 TTKB7T3 Strong Biomarker [165]
RGS6 TTJ96M8 Strong Biomarker [166]
ROBO4 TT3S9TY Strong Altered Expression [167]
RXFP1 TTMAHD1 Strong Altered Expression [168]
S100A4 TTPR5SX Strong Altered Expression [169]
S1PR2 TTVSMOH Strong Biomarker [170]
S1PR3 TTDYP7I Strong Biomarker [171]
SELPLG TTS5K8U Strong Biomarker [172]
SERPINA1 TTA7UJC Strong Genetic Variation [18]
SERPINE1 TTTO43N Strong Biomarker [20]
SERPINH1 TTPSWQG Strong Biomarker [173]
SETD7 TTJ0FSU Strong Biomarker [174]
SFTPD TTGLMU7 Strong Altered Expression [175]
SGPL1 TT618Q2 Strong Biomarker [176]
SIRT3 TTVZLIJ Strong Biomarker [177]
SLC52A2 TT6TKEN Strong Altered Expression [113]
SMN1 TT8QL6X Strong Biomarker [178]
SOD1 TTP9K3Q Strong Biomarker [178]
SPHK1 TTOHFIY Strong Biomarker [176]
SPP1 TT8ME6I Strong Altered Expression [179]
STAT1 TTN7R6K Strong Biomarker [180]
STAT3 TTHJT3X Strong Biomarker [119]
SULF2 TTLQTHB Strong Biomarker [181]
TERT TTQY2EJ Strong Genetic Variation [182]
TGFA TTTLQFR Strong Biomarker [183]
TGFBR2 TTZE3P7 Strong Biomarker [184]
TIAM1 TTNU6I5 Strong Biomarker [185]
TMBIM6 TT7QSMG Strong Biomarker [186]
TMPRSS11D TTWHYC8 Strong Biomarker [187]
TNC TTUCPMY Strong Altered Expression [188]
TNNC1 TT8RDXP Strong Altered Expression [189]
TOP1 TTGTQHC Strong Biomarker [190]
TPH1 TTZSJHV Strong Biomarker [191]
TRIP10 TTKHTGE Strong Altered Expression [192]
TRPA1 TTELV3W Strong Altered Expression [193]
TRPM8 TTXDKTO Strong Altered Expression [194]
TSLP TTHMW3T Strong Biomarker [195]
ULK1 TT4D7MJ Strong Biomarker [196]
VWF TT3SZBT Strong Biomarker [197]
IL37 TTQTX98 Definitive Biomarker [198]
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⏷ Show the Full List of 200 DTT(s)
This Disease Is Related to 3 DTP Molecule(s)
Gene Name DTP ID Evidence Level Mode of Inheritance REF
ABCA3 DT2T6VQ moderate Biomarker [199]
SLC52A1 DT7NOKR moderate Biomarker [113]
ANXA11 DTGQ2CF Strong Biomarker [200]
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This Disease Is Related to 3 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
CRMP1 DE0EUXB Limited Biomarker [32]
BLMH DECH1VP Strong Altered Expression [201]
DDAH1 DEY0TQC Strong Biomarker [202]
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This Disease Is Related to 202 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
BMP3 OTCTI0UW Limited Biomarker [203]
CHP1 OTHTXN1A Limited Biomarker [204]
COL3A1 OTT1EMLM Limited Altered Expression [188]
DAPK2 OTWODUQG Limited Biomarker [32]
DCTN4 OTM7C943 Limited Biomarker [205]
DENR OTXP9HOY Limited Biomarker [32]
DKC1 OTX7DJR6 Limited Biomarker [206]
ELN OTFSO7PG Limited Biomarker [207]
FAM13A OTZ6GN0Q Limited Biomarker [208]
HLA-DPB1 OTW8JHU2 Limited Genetic Variation [209]
LTBP4 OTC8WL2V Limited Biomarker [210]
PPL OTTM4WDO Limited Genetic Variation [211]
RHOV OTW4N3QN Limited Biomarker [204]
SOD3 OTIOZQAB Limited Biomarker [212]
STAT4 OTAK3VFR Limited Biomarker [26]
TM7SF2 OTILU5S7 Disputed Biomarker [79]
ACTA2 OTEDLG8E moderate Biomarker [213]
CBLIF OTNE20WU moderate Altered Expression [137]
CCL4 OT6B8P25 moderate Biomarker [214]
COL1A1 OTI31178 moderate Biomarker [215]
CTHRC1 OTV88X2G moderate Biomarker [216]
CXCL16 OTD49T9R moderate Biomarker [217]
DSP OTB2MOP8 moderate Genetic Variation [218]
ELK1 OTH9MXD6 moderate Altered Expression [219]
GPX4 OTRAFFX2 moderate Biomarker [220]
HAS2 OTTD3PAL moderate Biomarker [54]
HPS4 OTBTW01J moderate Genetic Variation [221]
IL18BP OTW0LRYZ moderate Biomarker [222]
LAMB1 OT6J9LJR moderate Altered Expression [223]
LCLAT1 OTCOP0JN moderate Biomarker [224]
LOXL1 OTA0NEJU moderate Biomarker [225]
MAP1LC3B OTUYHB84 moderate Biomarker [226]
MARCO OT0NW2Q0 moderate Biomarker [227]
MCU OTQZAYWQ moderate Altered Expression [228]
MIP OTEBLU3E moderate Altered Expression [229]
MOK OTQK7M9V moderate Biomarker [34]
NREP OT2AZPKK moderate Biomarker [230]
NUDT21 OTZHKWAR moderate Altered Expression [215]
RIPK3 OTL1D484 moderate Altered Expression [231]
RTEL1 OTI3PJCT moderate Biomarker [182]
STING1 OTDAP4G0 moderate Genetic Variation [232]
TFEB OTJUJJQY moderate Biomarker [233]
TINF2 OT861N2N Moderate Autosomal dominant [234]
TSPAN1 OTZQPIYK moderate Altered Expression [235]
ACE OTDF1964 Strong Biomarker [236]
ACKR2 OTWYY14H Strong Biomarker [237]
ADGRE2 OTUYJVYG Strong Biomarker [238]
ADGRE5 OTTSB84Q Strong Biomarker [238]
AEBP1 OTBI1RZ6 Strong Biomarker [239]
AP3B1 OTYTIH5Q Strong Genetic Variation [69]
ARID3A OTZZ4SFP Strong Biomarker [240]
ASPRV1 OT8WVIBW Strong Biomarker [241]
ATG12 OTJRO09Y Strong Altered Expression [242]
ATG4B OTQ4RNRM Strong Biomarker [243]
ATP6AP2 OT0IABVV Strong Biomarker [244]
ATP8B1 OTALGS63 Strong Biomarker [245]
B3GAT1 OTXFP98E Strong Biomarker [246]
B3GAT3 OTDSN5XF Strong Altered Expression [247]
BAD OT63ERYM Strong Biomarker [248]
BARD1 OTTC0Z9Y Strong Biomarker [249]
BLM OTEJOAJX Strong Biomarker [250]
CAPN9 OTE4IU5U Strong Biomarker [251]
CAST OTBXZZGF Strong Biomarker [252]
CBX5 OT8VYY84 Strong Biomarker [253]
CCL18 OT7JYSK9 Strong Altered Expression [254]
CCL24 OT9LGHV0 Strong Biomarker [255]
CCN4 OT69BER9 Strong Biomarker [256]
CCN5 OTADU8JJ Strong Altered Expression [257]
CCN6 OTRFHQ2Z Strong Biomarker [258]
CCR10 OT7ZWSSD Strong Biomarker [259]
CD151 OTF3UZS7 Strong Biomarker [260]
CDCP1 OTD7RRWK Strong Biomarker [261]
CFHR1 OT72R16T Strong Biomarker [262]
CRIP1 OT0EICG3 Strong Altered Expression [263]
CRISPLD2 OTVSFHTL Strong Biomarker [264]
CRNKL1 OTWBQNGU Strong Biomarker [99]
CSAD OT3I2G0A Strong Biomarker [265]
CSRP1 OTUS7RM2 Strong Altered Expression [263]
DDIT3 OTI8YKKE Strong Biomarker [266]
DECR1 OTCDIR6X Strong Biomarker [267]
DIO2 OTGPNSLH Strong Biomarker [268]
DNAH8 OTGES2OU Strong Biomarker [269]
DNER OT2GH2E5 Strong Biomarker [270]
DNM1L OTXK1Q1G Strong Biomarker [32]
E2F4 OTB3JFH4 Strong Biomarker [271]
EBF3 OTB0IWLW Strong Biomarker [272]
ECT2 OTQDUCT6 Strong Altered Expression [273]
EIF3A OTFABY9G Strong Biomarker [274]
EIF6 OTEXMUED Strong Biomarker [274]
ELMOD2 OTO5WT78 Strong Biomarker [275]
ELOVL6 OTB26UJJ Strong Biomarker [276]
ENC1 OTJEUB6U Strong Altered Expression [277]
FAM111B OT9IQ9NV Strong Genetic Variation [278]
FAM72A OTBZYSR3 Strong Biomarker [279]
FAM72B OT6AOG64 Strong Biomarker [279]
FBL OTRODIE5 Strong Genetic Variation [280]
FBLN5 OTLVNZ8U Strong Biomarker [53]
FBXO32 OTUE978R Strong Biomarker [136]
FGL1 OTT0QHQ1 Strong Biomarker [281]
FLT3LG OTU0YGC4 Strong Biomarker [282]
FOXD1 OT80PRHS Strong Biomarker [215]
FOXF1 OT2CJZ5K Strong Biomarker [283]
FSTL1 OT6KEZUD Strong Biomarker [284]
FUT8 OTJJCVG1 Strong Biomarker [285]
GAB1 OTQKE6V4 Strong Biomarker [286]
GAB2 OTBFN705 Strong Biomarker [286]
GABPA OT9YB2SA Strong Biomarker [154]
GGPS1 OTVEHG28 Strong Biomarker [287]
GTSE1 OTPP742Z Strong Biomarker [281]
H3-4 OTY6ITYF Strong Altered Expression [288]
HABP2 OTAUIPW0 Strong Biomarker [289]
HLF OTTRK9XN Strong Biomarker [290]
IL17B OTS86H50 Strong Biomarker [291]
ING4 OT0VVG4V Strong Altered Expression [292]
ING5 OTRNNSFM Strong Biomarker [141]
IRF5 OT8SIIAP Strong Genetic Variation [26]
ITGA9 OTHN1IKA Strong Altered Expression [277]
IVD OT8JFXUQ Strong Genetic Variation [293]
JTB OT314JB6 Strong Biomarker [294]
KCNMB1 OTO4KNJ4 Strong Biomarker [295]
KLF9 OTBFEJRQ Strong Altered Expression [296]
LAMA1 OTQZMP86 Strong Biomarker [297]
LOXL3 OTLLY1QI Strong Biomarker [298]
MFN1 OTCBXQZF Strong Biomarker [299]
MFN2 OTPYN8A3 Strong Biomarker [299]
MID1 OTWN1PGU Strong Altered Expression [300]
MMP19 OTLSTT2B Strong Biomarker [301]
MMP28 OTHQZXM1 Strong Altered Expression [302]
MMRN1 OT7ZNYHT Strong Biomarker [303]
MPG OTAHW80B Strong Biomarker [304]
MRTFA OTCVXASM Strong Biomarker [305]
MSC OTBRPZL5 Strong Biomarker [306]
NEU3 OTQ5PQOW Strong Biomarker [307]
NINJ1 OTLRZ1EU Strong Biomarker [308]
NKX2-5 OTS1SAWM Strong Biomarker [309]
NPNT OTFZAO1G Strong Biomarker [310]
P2RX2 OT0LF34A Strong Biomarker [157]
P2RX6 OT1FNTXA Strong Biomarker [157]
PARD3 OTH5BPLO Strong Biomarker [114]
PARN OTTG4PE3 Strong Genetic Variation [182]
PCLAF OTMVIOUU Strong Biomarker [311]
PGAM5 OT6Q5M0C Strong Biomarker [312]
PHEX OTG7N3J7 Strong Biomarker [178]
PIGN OTHHTJKX Strong Biomarker [313]
PINK1 OT50NR57 Strong Biomarker [314]
PIP OTH719AH Strong Biomarker [315]
PLXNC1 OTJ5XKYY Strong Biomarker [316]
POLE3 OTOELRF6 Strong Biomarker [279]
POU2AF1 OTOO6WHL Strong Biomarker [317]
PPP1R11 OTSHYPPW Strong Biomarker [78]
PPP1R13B OTC88VQO Strong Biomarker [318]
PRH1 OTQZ6HX0 Strong Altered Expression [319]
PRKAA1 OT7TNF0L Strong Altered Expression [320]
PRKAA2 OTU1KZPV Strong Altered Expression [320]
PRKAB1 OT1OG4QZ Strong Altered Expression [320]
PRX OT34Z10B Strong Biomarker [321]
PTX3 OTPXHRKU Strong Biomarker [322]
RAC2 OTAOHFNH Strong Biomarker [323]
RAMP2 OTGQXLH5 Strong Altered Expression [324]
RASAL1 OTAHUNN7 Strong Biomarker [325]
RBP2 OTR8QG5V Strong Biomarker [326]
RCN3 OTHWE0NF Strong Biomarker [327]
RETNLB OT9JJQQQ Strong Biomarker [328]
RMDN1 OTE1NB6U Strong Biomarker [205]
RNH1 OT6EC79B Strong Biomarker [329]
ROMO1 OTIEYVBW Strong Biomarker [330]
RPL17 OTTYMPS6 Strong Altered Expression [19]
SARS1 OTFKXQ1O Strong Biomarker [331]
SARS2 OTU4T99W Strong Biomarker [331]
SCGB3A2 OTB63PHR Strong Biomarker [332]
SDC4 OTKUVUGZ Strong Biomarker [333]
SEMA4A OT8901H3 Strong Altered Expression [334]
SEMA7A OT0ZJK64 Strong Biomarker [335]
SERPINE2 OTYF5340 Strong Biomarker [336]
SFTPA1 OT87XL1U Strong Altered Expression [231]
SFTPA2 OT6SFOMU Strong Genetic Variation [337]
SFTPC OTIZJD09 Strong Genetic Variation [338]
SIRT7 OT5M4OT4 Strong Biomarker [339]
SKI OT4KJ8F6 Strong Biomarker [340]
SKIL OTNBXH32 Strong Therapeutic [341]
SMAD2 OTC6VB4K Strong Biomarker [342]
SMAD4 OTWQWCKG Strong Altered Expression [343]
SMN2 OT54RLO1 Strong Biomarker [178]
SMOC2 OTK1EQ49 Strong Biomarker [344]
SNX9 OTLNQ0ZM Strong Altered Expression [345]
SPATA2 OTOA45GL Strong Altered Expression [19]
SPINT1 OT1CLR5L Strong Biomarker [346]
STX2 OTO2IDDR Strong Biomarker [347]
SULF1 OTJCNCO0 Strong Biomarker [181]
SYBU OT3FQV7N Strong Biomarker [205]
SYT7 OTBWAOWY Strong Biomarker [316]
TCIM OTARUXQF Strong Posttranslational Modification [348]
THY1 OTVONVTB Strong Altered Expression [349]
TICAM2 OTK7GIJ5 Strong Biomarker [350]
TIMP1 OTOXC51H Strong Biomarker [61]
TM4SF5 OTPAV531 Strong Biomarker [351]
TMED7 OTONO8E6 Strong Biomarker [350]
TMPRSS4 OTCCGY2K Strong Altered Expression [352]
TRAM1 OT3I0H8E Strong Biomarker [353]
TRIB3 OTG5OS7X Strong Biomarker [354]
TRIM16 OTLRXYOZ Strong Genetic Variation [355]
NAF1 OTMJKJAK Definitive Genetic Variation [356]
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⏷ Show the Full List of 202 DOT(s)

References

1 ClinicalTrials.gov (NCT01083524) Dichloroacetate (DCA) for the Treatment of Pulmonary Arterial Hypertension. U.S. National Institutes of Health.
2 ClinicalTrials.gov (NCT04308681) A Multicenter, Randomized, Double-blind, Placebo-controlled, Phase 2 Study of the Efficacy and the Safety and Tolerability of BMS-986278 in Participants With Pulmonary Fibrosis. U.S.National Institutes of Health.
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 771).
4 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800034106)
5 ClinicalTrials.gov (NCT05354453) Safety, Tolerability, and Pharmacokinetics of Single Rising Oral Doses of BI 1839100 in Healthy Male Subjects (Single-blind, Randomised, Placebo-controlled, Parallel Group Design). U.S.National Institutes of Health.
6 ClinicalTrials.gov (NCT04550195) A Double-Blind, Placebo-Controlled, Randomized, Single and Multiple Ascending Dose Study of the Safety and Tolerability, and Pharmacokinetics (Including Food Effect, pH Effect and Japanese Bridging Study) of BMS-986337 Following Oral Administration in Healthy Participants. U.S.National Institutes of Health.
7 Drugs and Targets in Fibrosis. Front Pharmacol. 2017 Nov 23;8:855.
8 Targeting metabolic dysregulation for fibrosis therapy. Nat Rev Drug Discov. 2020 Jan;19(1):57-75.
9 Targeting of alphav integrin identifies a core molecular pathway that regulates fibrosis in several organs. Nat Med. 2013 Dec;19(12):1617-24.
10 Opportunities for therapeutic antibodies directed at G-protein-coupled receptors. Nat Rev Drug Discov. 2017 Sep;16(9):787-810.
11 PI3K-Akt-mTOR/PFKFB3 pathway mediated lung fibroblast aerobic glycolysis and collagen synthesis in lipopolysaccharide-induced pulmonary fibrosis. Lab Invest. 2020 Jun;100(6):801-811.
12 The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
13 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1788).
14 Salvia officinalis attenuates bleomycin-induced oxidative stress and lung fibrosis in rats.Nutr Cancer. 2020;72(7):1135-1145. doi: 10.1080/01635581.2019.1675724. Epub 2019 Oct 12.
15 Caveolin-1-derived peptide limits development of pulmonary fibrosis.Sci Transl Med. 2019 Dec 11;11(522):eaat2848. doi: 10.1126/scitranslmed.aat2848.
16 Relationship between eosinophilia and levels of chemokines (CCL5 and CCL11) and IL-5 in bronchoalveolar lavage fluid of patients with mustard gas-induced pulmonary fibrosis.J Clin Immunol. 2007 Nov;27(6):605-12. doi: 10.1007/s10875-007-9114-y. Epub 2007 Jul 10.
17 Targeting Degradation of the Transcription Factor C/EBP Reduces Lung Fibrosis by Restoring Activity of the Ubiquitin-Editing Enzyme A20 in Macrophages.Immunity. 2019 Sep 17;51(3):522-534.e7. doi: 10.1016/j.immuni.2019.06.014. Epub 2019 Aug 27.
18 Therapeutic strategies to correct proteostasis-imbalance in chronic obstructive lung diseases.Curr Mol Med. 2012 Aug;12(7):807-14. doi: 10.2174/156652412801318809.
19 Characterization of CD28(null) T cells in idiopathic pulmonary fibrosis.Mucosal Immunol. 2019 Jan;12(1):212-222. doi: 10.1038/s41385-018-0082-8. Epub 2018 Oct 12.
20 The fibrogenic actions of the coagulant and plasminogen activation systems in pulmonary fibrosis.Int J Biochem Cell Biol. 2018 Apr;97:108-117. doi: 10.1016/j.biocel.2018.02.016. Epub 2018 Feb 21.
21 Quercetin Enhances Ligand-induced Apoptosis in Senescent Idiopathic Pulmonary Fibrosis Fibroblasts and Reduces Lung Fibrosis In Vivo.Am J Respir Cell Mol Biol. 2019 Jan;60(1):28-40. doi: 10.1165/rcmb.2017-0289OC.
22 Fibroblast growth factor-1 attenuates TGF-1-induced lung fibrosis.J Pathol. 2016 Oct;240(2):197-210. doi: 10.1002/path.4768.
23 Nrf2 antioxidant pathway suppresses Numb-mediated epithelial-mesenchymal transition during pulmonary fibrosis.Cell Death Dis. 2018 Jan 23;9(2):83. doi: 10.1038/s41419-017-0198-x.
24 Acute Lung Injury: IL-17A-Mediated Inflammatory Pathway and Its Regulation by Curcumin.Inflammation. 2019 Aug;42(4):1160-1169. doi: 10.1007/s10753-019-01010-4.
25 Biomarkers of skin and lung fibrosis in systemic sclerosis.Expert Rev Clin Immunol. 2019 Nov;15(11):1215-1223. doi: 10.1080/1744666X.2020.1670062. Epub 2019 Sep 30.
26 The status of pulmonary fibrosis in systemic sclerosis is associated with IRF5, STAT4, IRAK1, and CTGF polymorphisms.Rheumatol Int. 2017 Aug;37(8):1303-1310. doi: 10.1007/s00296-017-3722-5. Epub 2017 Apr 22.
27 Repression of TSC1/TSC2 mediated by MeCP2 regulates human embryo lung fibroblast cell differentiation and proliferation.Int J Biol Macromol. 2017 Mar;96:578-588. doi: 10.1016/j.ijbiomac.2016.12.062. Epub 2016 Dec 29.
28 Interleukin-7 and transforming growth factor-beta play counter-regulatory roles in protein kinase C-delta-dependent control of fibroblast collagen synthesis in pulmonary fibrosis.J Biol Chem. 2004 Jul 2;279(27):28315-9. doi: 10.1074/jbc.C400115200. Epub 2004 May 7.
29 Anti-citrullinated peptides antibodies in systemic sclerosis: Meta-analysis of frequency and meaning.Joint Bone Spine. 2018 Mar;85(2):147-153. doi: 10.1016/j.jbspin.2017.11.006. Epub 2017 Nov 26.
30 A STAT6 Inhibitor AS1517499 Reduces Preventive Effects of Apoptotic Cell Instillation on Bleomycin-Induced Lung Fibrosis by Suppressing PPAR.Cell Physiol Biochem. 2018;45(5):1863-1877. doi: 10.1159/000487877. Epub 2018 Feb 28.
31 Transforming growth factor-{beta} gene polymorphisms in different phenotypes of sarcoidosis.Eur Respir J. 2011 Jul;38(1):169-75. doi: 10.1183/09031936.00120410. Epub 2010 Dec 9.
32 miR-30a as Potential Therapeutics by Targeting TET1 through Regulation of Drp-1 Promoter Hydroxymethylation in Idiopathic Pulmonary Fibrosis. Int J Mol Sci. 2017 Mar 15;18(3). pii: E633.
33 HIF1A up-regulates the ADORA2B receptor on alternatively activated macrophages and contributes to pulmonary fibrosis.FASEB J. 2017 Nov;31(11):4745-4758. doi: 10.1096/fj.201700219R. Epub 2017 Jul 12.
34 miR-627/HMGB1/NF-B regulatory loop modulates TGF-1-induced pulmonary fibrosis.J Cell Biochem. 2019 Mar;120(3):2983-2993. doi: 10.1002/jcb.27038. Epub 2018 Dec 9.
35 Inhibitory effects of pirfenidone on fibroblast to myofibroblast transition in rheumatoid arthritis-associated interstitial lung disease via the downregulation of activating transcription factor 3 (ATF3).Int Immunopharmacol. 2019 Sep;74:105700. doi: 10.1016/j.intimp.2019.105700. Epub 2019 Jun 19.
36 Pirfenidone attenuates bleomycin-induced pulmonary fibrosis in mice by regulating Nrf2/Bach1 equilibrium.BMC Pulm Med. 2017 Apr 18;17(1):63. doi: 10.1186/s12890-017-0405-7.
37 Role of Eotaxin-1 (CCL11) and CC chemokine receptor 3 (CCR3) in bleomycin-induced lung injury and fibrosis.Am J Pathol. 2005 Dec;167(6):1485-96. doi: 10.1016/S0002-9440(10)61235-7.
38 Elevated expression of TARC (CCL17) and MDC (CCL22) in models of cigarette smoke-induced pulmonary inflammation.Biochem Biophys Res Commun. 2005 Aug 19;334(1):254-62. doi: 10.1016/j.bbrc.2005.06.084.
39 Cadherin-11 contributes to liver fibrosis induced by carbon tetrachloride.PLoS One. 2019 Jul 3;14(7):e0218971. doi: 10.1371/journal.pone.0218971. eCollection 2019.
40 Pirfenidone activates cannabinoid receptor 2 in a mouse model of bleomycin-induced pulmonary fibrosis.Exp Ther Med. 2019 Dec;18(6):4241-4248. doi: 10.3892/etm.2019.8045. Epub 2019 Sep 25.
41 Important roles for macrophage colony-stimulating factor, CC chemokine ligand 2, and mononuclear phagocytes in the pathogenesis of pulmonary fibrosis.Am J Respir Crit Care Med. 2007 Jul 1;176(1):78-89. doi: 10.1164/rccm.200609-1279OC. Epub 2007 Apr 12.
42 Pretreatment with G-CSF Could Enhance the Antifibrotic Effect of BM-MSCs on Pulmonary Fibrosis.Stem Cells Int. 2019 Jan 3;2019:1726743. doi: 10.1155/2019/1726743. eCollection 2019.
43 Neotuberostemonine inhibits the differentiation of lung fibroblasts into myofibroblasts in mice by regulating HIF-1 signaling.Acta Pharmacol Sin. 2018 Sep;39(9):1501-1512. doi: 10.1038/aps.2017.202. Epub 2018 Apr 12.
44 MiR-34b-5p knockdown attenuates bleomycin-induced pulmonary fibrosis by targeting tissue inhibitor of metalloproteinase 3 (TIMP3).Eur Rev Med Pharmacol Sci. 2019 Mar;23(5):2273-2279. doi: 10.26355/eurrev_201903_17276.
45 (18)F-AzaFol for Detection of Folate Receptor- Positive Macrophages in Experimental Interstitial Lung Disease-A Proof-of-Concept Study.Front Immunol. 2019 Nov 22;10:2724. doi: 10.3389/fimmu.2019.02724. eCollection 2019.
46 Knockdown of Fstl1 attenuates hepatic stellate cell activation through the TGF?/Smad3 signaling pathway.Mol Med Rep. 2017 Nov;16(5):7119-7123. doi: 10.3892/mmr.2017.7445. Epub 2017 Sep 8.
47 Redox Regulation via Glutaredoxin-1 and Protein S-Glutathionylation.Antioxid Redox Signal. 2020 Apr 1;32(10):677-700. doi: 10.1089/ars.2019.7963. Epub 2020 Jan 23.
48 HDAC8 inhibition ameliorates pulmonary fibrosis.Am J Physiol Lung Cell Mol Physiol. 2019 Jan 1;316(1):L175-L186. doi: 10.1152/ajplung.00551.2017. Epub 2018 Oct 25.
49 IL1RN genetic variations and risk of IPF: a meta-analysis and mRNA expression study.Immunogenetics. 2012 May;64(5):371-7. doi: 10.1007/s00251-012-0604-6. Epub 2012 Feb 10.
50 Reduced Ets Domain-containing Protein Elk1 Promotes Pulmonary Fibrosis via Increased Integrin v6 Expression.J Biol Chem. 2016 Apr 29;291(18):9540-53. doi: 10.1074/jbc.M115.692368. Epub 2016 Feb 9.
51 Prevention and treatment of bleomycin-induced pulmonary fibrosis with the lactate dehydrogenase inhibitor gossypol.PLoS One. 2018 May 24;13(5):e0197936. doi: 10.1371/journal.pone.0197936. eCollection 2018.
52 BLT1 Mediates Bleomycin-Induced Lung Fibrosis Independently of Neutrophils and CD4+ T Cells.J Immunol. 2017 Feb 15;198(4):1673-1684. doi: 10.4049/jimmunol.1600465. Epub 2017 Jan 11.
53 Specific Features of Fibrotic Lung Fibroblasts Highly Sensitive to Fibrotic Processes Mediated via TGF--ERK5 Interaction.Cell Physiol Biochem. 2019;52(4):822-837. doi: 10.33594/000000057.
54 Mitogen-activated Protein Kinase-activated Protein Kinase 2 Inhibition Attenuates Fibroblast Invasion and Severe Lung Fibrosis.Am J Respir Cell Mol Biol. 2019 Jan;60(1):41-48. doi: 10.1165/rcmb.2018-0033OC.
55 Matrix Metalloproteinases-7 and Kidney Fibrosis.Front Physiol. 2017 Feb 10;8:21. doi: 10.3389/fphys.2017.00021. eCollection 2017.
56 The Role of the Mammalian Target of Rapamycin (mTOR) in Pulmonary Fibrosis.Int J Mol Sci. 2018 Mar 8;19(3):778. doi: 10.3390/ijms19030778.
57 Invivo effects of the NLRP1/NLRP3 inflammasome pathway on latent respiratory virus infection.Int J Mol Med. 2018 Jun;41(6):3620-3628. doi: 10.3892/ijmm.2018.3521. Epub 2018 Feb 28.
58 NOX4 modulates macrophage phenotype and mitochondrial biogenesis in asbestosis.JCI Insight. 2019 Aug 22;4(16):e126551. doi: 10.1172/jci.insight.126551.
59 Oncostatin M-Preconditioned Mesenchymal Stem Cells Alleviate Bleomycin-Induced Pulmonary Fibrosis Through Paracrine Effects of the Hepatocyte Growth Factor.Stem Cells Transl Med. 2017 Mar;6(3):1006-1017. doi: 10.5966/sctm.2016-0054. Epub 2016 Oct 18.
60 Effects of PARP-1 Deficiency and Histamine H(4) Receptor Inhibition in an Inflammatory Model of Lung Fibrosis in Mice.Front Pharmacol. 2019 May 16;10:525. doi: 10.3389/fphar.2019.00525. eCollection 2019.
61 Therapeutic effects of obeticholic acid (OCA) treatment in a bleomycin-induced pulmonary fibrosis rat model.J Endocrinol Invest. 2019 Mar;42(3):283-294. doi: 10.1007/s40618-018-0913-1. Epub 2018 Jun 19.
62 Biomarkers for Pulmonary Vascular Remodeling in Systemic Sclerosis: A Pathophysiological Approach.Front Physiol. 2018 Jun 19;9:587. doi: 10.3389/fphys.2018.00587. eCollection 2018.
63 Reduced supply of monocyte-derived macrophages leads to a transition from nodular to diffuse lesions and tissue cell activation in silica-induced pulmonary fibrosis in mice.Am J Pathol. 2015 Nov;185(11):2923-38. doi: 10.1016/j.ajpath.2015.07.013. Epub 2015 Oct 9.
64 The Rho Kinase Isoforms ROCK1 and ROCK2 Each Contribute to the Development of Experimental Pulmonary Fibrosis.Am J Respir Cell Mol Biol. 2018 Apr;58(4):471-481. doi: 10.1165/rcmb.2017-0075OC.
65 Syndecan-2 Attenuates Radiation-induced Pulmonary Fibrosis and Inhibits Fibroblast Activation by Regulating PI3K/Akt/ROCK Pathway via CD148.Am J Respir Cell Mol Biol. 2018 Feb;58(2):208-215. doi: 10.1165/rcmb.2017-0088OC.
66 Overexpression of SERPIN B3 promotes epithelial proliferation and lung fibrosis in mice.Lab Invest. 2011 Jun;91(6):945-54. doi: 10.1038/labinvest.2011.1. Epub 2011 Mar 14.
67 Sirtuin 6 inhibits MWCNTs-induced epithelial-mesenchymal transition in human bronchial epithelial cells via inactivating TGF-1/Smad2 signaling pathway.Toxicol Appl Pharmacol. 2019 Jul 1;374:1-10. doi: 10.1016/j.taap.2019.04.013. Epub 2019 Apr 18.
68 SET9-Mediated Regulation of TGF- Signaling Links Protein Methylation to Pulmonary Fibrosis.Cell Rep. 2016 Jun 21;15(12):2733-44. doi: 10.1016/j.celrep.2016.05.051. Epub 2016 Jun 9.
69 Pulmonary Fibrosis in Hermansky-Pudlak Syndrome.Ann Am Thorac Soc. 2016 Oct;13(10):1839-1846. doi: 10.1513/AnnalsATS.201603-186FR.
70 Roles of high-mobility group box 1 and thrombin in murine pulmonary fibrosis and the therapeutic potential of thrombomodulin.Am J Physiol Lung Cell Mol Physiol. 2018 Mar 1;314(3):L473-L483. doi: 10.1152/ajplung.00287.2017. Epub 2017 Dec 6.
71 Role of bone marrow mesenchymal stem cells in the development of PQinduced pulmonary fibrosis.Mol Med Rep. 2019 Apr;19(4):3283-3290. doi: 10.3892/mmr.2019.9976. Epub 2019 Feb 20.
72 Tumor necrosis factor family member LIGHT acts with IL-1 and TGF- to promote airway remodeling during rhinovirus infection.Allergy. 2018 Jul;73(7):1415-1424. doi: 10.1111/all.13390. Epub 2018 Mar 1.
73 A pneumocyte-macrophage paracrine lipid axis drives the lung toward fibrosis.Am J Respir Cell Mol Biol. 2015 Jul;53(1):74-86. doi: 10.1165/rcmb.2014-0343OC.
74 Interaction of N-acetyl-seryl-aspartyl-lysyl-proline with the angiotensin-converting enzyme2-angiotensin-(1-7)-Mas axis attenuates pulmonary fibrosis in silicotic rats.Exp Physiol. 2019 Oct;104(10):1562-1574. doi: 10.1113/EP087515. Epub 2019 Aug 13.
75 The Role of Mitochondrial DNA in Mediating Alveolar Epithelial Cell Apoptosis and Pulmonary Fibrosis.Int J Mol Sci. 2015 Sep 7;16(9):21486-519. doi: 10.3390/ijms160921486.
76 ADAM33 gene polymorphisms are associated with the risk of idiopathic pulmonary fibrosis.Lung. 2014 Aug;192(4):525-32. doi: 10.1007/s00408-014-9578-5. Epub 2014 Apr 13.
77 Adiponectin attenuates lung fibroblasts activation and pulmonary fibrosis induced by paraquat. PLoS One. 2015 May 6;10(5):e0125169. doi: 10.1371/journal.pone.0125169. eCollection 2015.
78 Autophagy Attenuates Angiotensin II-Induced Pulmonary Fibrosis by Inhibiting Redox Imbalance-Mediated NOD-Like Receptor Family Pyrin Domain Containing 3 Inflammasome Activation.Antioxid Redox Signal. 2019 Feb 1;30(4):520-541. doi: 10.1089/ars.2017.7261. Epub 2018 May 7.
79 Effect of preventive or therapeutic treatment with angiotensin 1-7 in a model of bleomycin-induced lung fibrosis in mice.J Leukoc Biol. 2019 Sep;106(3):677-686. doi: 10.1002/JLB.MA1218-490RR. Epub 2019 Jun 30.
80 Identification of annexin 1 as a novel autoantigen in acute exacerbation of idiopathic pulmonary fibrosis.J Immunol. 2008 Jul 1;181(1):756-67. doi: 10.4049/jimmunol.181.1.756.
81 Amine oxidase activity regulates the development of pulmonary fibrosis.FASEB J. 2017 Jun;31(6):2477-2491. doi: 10.1096/fj.201600935R. Epub 2017 Mar 1.
82 The immunopathology of lung fibrosis: amphiregulin-producing pathogenic memory T helper-2 cells control the airway fibrotic responses by inducing eosinophils to secrete osteopontin.Semin Immunopathol. 2019 May;41(3):339-348. doi: 10.1007/s00281-019-00735-6. Epub 2019 Apr 9.
83 Anti-fibrotic effects of bone morphogenetic protein-7-modified bone marrow mesenchymal stem cells on silica-induced pulmonary fibrosis.Exp Mol Pathol. 2017 Feb;102(1):70-77. doi: 10.1016/j.yexmp.2016.12.010. Epub 2017 Jan 4.
84 Macrophage bone morphogenic protein receptor 2 depletion in idiopathic pulmonary fibrosis and Group III pulmonary hypertension.Am J Physiol Lung Cell Mol Physiol. 2016 Aug 1;311(2):L238-54. doi: 10.1152/ajplung.00142.2016. Epub 2016 Jun 17.
85 Contribution of the anaphylatoxin receptors, C3aR and C5aR, to the pathogenesis of pulmonary fibrosis.FASEB J. 2016 Jun;30(6):2336-50. doi: 10.1096/fj.201500044. Epub 2016 Mar 8.
86 Calcitonin gene-related peptide (CGRP) as hazard marker for lung injury induced by dusts.Inhal Toxicol. 2007 Mar;19(3):283-9. doi: 10.1080/08958370601069364.
87 Intranasal Curcumin Inhibits Pulmonary Fibrosis by Modulating Matrix Metalloproteinase-9 (MMP-9) in Ovalbumin-Induced Chronic Asthma.Inflammation. 2017 Feb;40(1):248-258. doi: 10.1007/s10753-016-0475-3.
88 Alternatively activated alveolar macrophages in pulmonary fibrosis-mediator production and intracellular signal transduction.Clin Immunol. 2010 Oct;137(1):89-101. doi: 10.1016/j.clim.2010.06.017. Epub 2010 Jul 31.
89 Elevated levels of MCP-1, MIP-alpha and MIP-1 beta in the bronchoalveolar lavage (BAL) fluid of patients with mustard gas-induced pulmonary fibrosis.Toxicology. 2007 Oct 30;240(1-2):60-9. doi: 10.1016/j.tox.2007.07.014. Epub 2007 Aug 1.
90 Palmitic Acid-Rich High-Fat Diet Exacerbates Experimental Pulmonary Fibrosis by Modulating Endoplasmic Reticulum Stress.Am J Respir Cell Mol Biol. 2019 Dec;61(6):737-746. doi: 10.1165/rcmb.2018-0324OC.
91 NLRP3 Inflammasome Activation Contributes to Mechanical Stretch-Induced Endothelial-Mesenchymal Transition and Pulmonary Fibrosis.Crit Care Med. 2018 Jan;46(1):e49-e58. doi: 10.1097/CCM.0000000000002799.
92 Taurine ameliorates particulate matter-induced emphysema by switching on mitochondrial NADH dehydrogenase genes.Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):E9655-E9664. doi: 10.1073/pnas.1712465114. Epub 2017 Oct 25.
93 Adipokine adipsin is associated with the degree of lung fibrosis in asbestos-exposed workers.Respir Med. 2012 Oct;106(10):1435-40. doi: 10.1016/j.rmed.2012.07.003. Epub 2012 Jul 24.
94 Deficiency of 7 nicotinic acetylcholine receptor attenuates bleomycin-induced lung fibrosis in mice.Mol Med. 2017 Apr;23:34-39. doi: 10.2119/molmed.2016.00083. Epub 2017 Mar 6.
95 Prognostic Biomarkers of Sarcoidosis: A Comparative Study of Serum Chitotriosidase, ACE, Lysozyme, and KL-6.Dis Markers. 2019 Mar 3;2019:8565423. doi: 10.1155/2019/8565423. eCollection 2019.
96 Silencing of Carbohydrate Sulfotransferase 15 Hinders Murine Pulmonary Fibrosis Development.Mol Ther Nucleic Acids. 2017 Mar 17;6:163-172. doi: 10.1016/j.omtn.2016.12.008. Epub 2016 Dec 31.
97 Chymase is activated in the pulmonary inflammation and fibrosis induced by paraquat in hamsters.Tohoku J Exp Med. 2004 Aug;203(4):287-94. doi: 10.1620/tjem.203.287.
98 Pivotal role of connective tissue growth factor in lung fibrosis: MAPK-dependent transcriptional activation of type I collagen.Arthritis Rheum. 2009 Jul;60(7):2142-55. doi: 10.1002/art.24620.
99 Cytokine-like factor 1 gene expression is enriched in idiopathic pulmonary fibrosis and drives the accumulation of CD4+ T cells in murine lungs: evidence for an antifibrotic role in bleomycin injury.Am J Pathol. 2012 May;180(5):1963-78. doi: 10.1016/j.ajpath.2012.01.010. Epub 2012 Mar 16.
100 Increased granulocyte-colony stimulating factor (G-CSF) and granulocyte-macrophage colony stimulating factor (GM-CSF) levels in BAL fluid from patients with sulfur mustard gas-induced pulmonary fibrosis.J Aerosol Med. 2007 Fall;20(3):352-60. doi: 10.1089/jam.2007.0590.
101 Casein Kinase 1/ Inhibitor, PF670462 Attenuates the Fibrogenic Effects of Transforming Growth Factor- in Pulmonary Fibrosis.Front Pharmacol. 2018 Jul 10;9:738. doi: 10.3389/fphar.2018.00738. eCollection 2018.
102 Gene expression of cytokines and growth factors in the lungs after paraquat administration in mice.Leg Med (Tokyo). 2006 Mar;8(2):102-9. doi: 10.1016/j.legalmed.2005.08.010. Epub 2005 Dec 1.
103 Megakaryocytes participate in the occurrence of bleomycin-induced pulmonary fibrosis.Cell Death Dis. 2019 Sep 9;10(9):648. doi: 10.1038/s41419-019-1903-8.
104 [Lung fibrosis induced by mechanical ventilation with different tidal volume in neonatal rats].Zhongguo Dang Dai Er Ke Za Zhi. 2010 Oct;12(10):799-803.
105 Targeted gene disruption reveals the role of the cysteinyl leukotriene 2 receptor in increased vascular permeability and in bleomycin-induced pulmonary fibrosis in mice.J Biol Chem. 2004 Oct 29;279(44):46129-34. doi: 10.1074/jbc.M407057200. Epub 2004 Aug 24.
106 Role of a novel immune modulating DDR2-expressing population in silica-induced pulmonary fibrosis.PLoS One. 2017 Jul 10;12(7):e0180724. doi: 10.1371/journal.pone.0180724. eCollection 2017.
107 Genome-Wide Association Study of Susceptibility to Idiopathic Pulmonary Fibrosis.Am J Respir Crit Care Med. 2020 Mar 1;201(5):564-574. doi: 10.1164/rccm.201905-1017OC.
108 Role of dual-specificity protein phosphatase DUSP10/MKP-5 in pulmonary fibrosis.Am J Physiol Lung Cell Mol Physiol. 2019 Nov 1;317(5):L678-L689. doi: 10.1152/ajplung.00264.2018. Epub 2019 Sep 4.
109 Endothelin-converting enzyme-1 gene ablation attenuates pulmonary fibrosis via CGRP-cAMP/EPAC1 pathway.Am J Respir Cell Mol Biol. 2013 Apr;48(4):465-76. doi: 10.1165/rcmb.2012-0354OC.
110 Activation of PERK in ET-1- and thrombin-induced pulmonary fibroblast differentiation: Inhibitory effects of curcumin.J Cell Physiol. 2019 Sep;234(9):15977-15988. doi: 10.1002/jcp.28256. Epub 2019 Mar 1.
111 Neutrophil elastase promotes myofibroblast differentiation in lung fibrosis.J Leukoc Biol. 2015 Aug;98(2):143-52. doi: 10.1189/jlb.3HI1014-493R. Epub 2015 Mar 5.
112 Uncoupling of the profibrotic and hemostatic effects of thrombin in lung fibrosis.JCI Insight. 2017 May 4;2(9):e86608. doi: 10.1172/jci.insight.86608. eCollection 2017 May 4.
113 Protease-activated receptor (PAR)-2 is required for PAR-1 signalling in pulmonary fibrosis.J Cell Mol Med. 2015 Jun;19(6):1346-56. doi: 10.1111/jcmm.12520. Epub 2015 Feb 16.
114 Protease-activated receptors (PAR)-1 and -3 drive epithelial-mesenchymal transition of alveolar epithelial cells - potential role in lung fibrosis.Thromb Haemost. 2013 Aug;110(2):295-307. doi: 10.1160/TH12-11-0854. Epub 2013 Jun 6.
115 Adenovirus vector expressing keratinocyte growth factor using CAG promoter impairs pulmonary function of mice with elastase-induced emphysema.Microbiol Immunol. 2017 Jul;61(7):264-271. doi: 10.1111/1348-0421.12492.
116 Developmental regulation and coordinate reexpression of FKBP65 with extracellular matrix proteins after lung injury suggest a specialized function for this endoplasmic reticulum immunophilin.Cell Stress Chaperones. 2005 Winter;10(4):285-95. doi: 10.1379/csc-118r.1.
117 Transcription factor Fra-2 and its emerging role in matrix deposition, proliferation and inflammation in chronic lung diseases.Cell Signal. 2019 Dec;64:109408. doi: 10.1016/j.cellsig.2019.109408. Epub 2019 Aug 29.
118 PACE: A Probabilistic Atlas for Normal Tissue Complication Estimation in Radiation Oncology.Front Oncol. 2019 Mar 13;9:130. doi: 10.3389/fonc.2019.00130. eCollection 2019.
119 Aberrant expression of miR-125a-3p promotes fibroblast activation via Fyn/STAT3 pathway during silica-induced pulmonary fibrosis.Toxicology. 2019 Feb 15;414:57-67. doi: 10.1016/j.tox.2019.01.007. Epub 2019 Jan 15.
120 Frizzled-7 mediates TGF--induced pulmonary fibrosis by transmitting non-canonical Wnt signaling.Exp Cell Res. 2017 Oct 1;359(1):226-234. doi: 10.1016/j.yexcr.2017.07.025. Epub 2017 Jul 20.
121 Genetic loss of Gas6/Mer pathway attenuates silica-induced lung inflammation and fibrosis in mice.Toxicol Lett. 2019 Oct 1;313:178-187. doi: 10.1016/j.toxlet.2019.07.008. Epub 2019 Jul 5.
122 The Hedgehog target Gli1 is not required for bleomycin-induced lung fibrosis.Exp Lung Res. 2019 Feb-Mar;45(1-2):22-29. doi: 10.1080/01902148.2019.1601795. Epub 2019 Apr 13.
123 Genetic variation in GREM1 is a risk factor for fibrosis in pulmonary sarcoidosis.Tissue Antigens. 2011 Feb;77(2):112-7. doi: 10.1111/j.1399-0039.2010.01590.x.
124 Grainyhead-like 2 (GRHL2) distribution reveals novel pathophysiological differences between human idiopathic pulmonary fibrosis and mouse models of pulmonary fibrosis.Am J Physiol Lung Cell Mol Physiol. 2014 Mar 1;306(5):L405-19. doi: 10.1152/ajplung.00143.2013. Epub 2013 Dec 27.
125 Orally administered berberine ameliorates bleomycin-induced pulmonary fibrosis in mice through promoting activation of PPAR- and subsequent expression of HGF in colons. Toxicol Appl Pharmacol. 2018 Mar 15;343:1-15. doi: 10.1016/j.taap.2018.02.001. Epub 2018 Feb 3.
126 Synergistic role of HSP90 and HSP90 to promote myofibroblast persistence in lung fibrosis.Eur Respir J. 2018 Jan 31;51(2):1700386. doi: 10.1183/13993003.00386-2017. Print 2018 Feb.
127 The Hsp27-Mediated IkB-NFB Signaling Axis Promotes Radiation-Induced Lung Fibrosis.Clin Cancer Res. 2019 Sep 1;25(17):5364-5375. doi: 10.1158/1078-0432.CCR-18-3900. Epub 2019 May 24.
128 Role of heat shock protein 60 (HSP60) on paraquat intoxication.J Appl Toxicol. 2001 Sep-Oct;21(5):425-30. doi: 10.1002/jat.774.
129 The effects of aerosolized STAT1 antisense oligodeoxynucleotides on rat pulmonary fibrosis.Cell Mol Immunol. 2009 Feb;6(1):51-9. doi: 10.1038/cmi.2009.7.
130 MicroRNA let-7 Downregulates Ligand-Independent Estrogen Receptor-mediated Male-Predominant Pulmonary Fibrosis.Am J Respir Crit Care Med. 2019 Nov 15;200(10):1246-1257. doi: 10.1164/rccm.201903-0508OC.
131 Interleukin-11 is a therapeutic target in idiopathic pulmonary fibrosis.Sci Transl Med. 2019 Sep 25;11(511):eaaw1237. doi: 10.1126/scitranslmed.aaw1237.
132 A profibrotic function of IL-12p40 in experimental pulmonary fibrosis.J Immunol. 2002 Sep 1;169(5):2653-61. doi: 10.4049/jimmunol.169.5.2653.
133 Role of B7H3/IL-33 Signaling in Pulmonary Fibrosis-induced Profibrogenic Alterations in Bone Marrow.Am J Respir Crit Care Med. 2019 Oct 15;200(8):1032-1044. doi: 10.1164/rccm.201808-1560OC.
134 IL-1-IL-17 Signaling Axis Contributes to Fibrosis and Inflammation in Two Different Murine Models of Systemic Sclerosis.Front Immunol. 2018 Jul 10;9:1611. doi: 10.3389/fimmu.2018.01611. eCollection 2018.
135 An ST2-dependent role of bone marrow-derived group 2 innate lymphoid cells in pulmonary fibrosis.J Pathol. 2018 Aug;245(4):399-409. doi: 10.1002/path.5092. Epub 2018 Jun 5.
136 Elevation of IL-6 and IL-33 Levels in Serum Associated with Lung Fibrosis and Skeletal Muscle Wasting in a Bleomycin-Induced Lung Injury Mouse Model.Mediators Inflamm. 2019 Mar 27;2019:7947596. doi: 10.1155/2019/7947596. eCollection 2019.
137 Valsartan attenuates bleomycin-induced pulmonary fibrosis by inhibition of NF-B expression and regulation of Th1/Th2 cytokines.Immunopharmacol Immunotoxicol. 2018 Jun;40(3):225-231. doi: 10.1080/08923973.2018.1431924. Epub 2018 Feb 15.
138 AQX-1125, small molecule SHIP1 activator inhibits bleomycin-induced pulmonary fibrosis.Br J Pharmacol. 2017 Sep;174(18):3045-3057. doi: 10.1111/bph.13934. Epub 2017 Aug 11.
139 miR-542-5p Attenuates Fibroblast Activation by Targeting Integrin 6 in Silica-Induced Pulmonary Fibrosis.Int J Mol Sci. 2018 Nov 22;19(12):3717. doi: 10.3390/ijms19123717.
140 Modulation of CD11c+ lung dendritic cells in respect to TGF- in experimental pulmonary fibrosis.Cell Biol Int. 2017 Sep;41(9):991-1000. doi: 10.1002/cbin.10800. Epub 2017 Jul 16.
141 Expression analysis of microRNAs and mRNAs in myofibroblast differentiation of lung resident mesenchymal stem cells.Differentiation. 2020 Mar-Apr;112:10-16. doi: 10.1016/j.diff.2019.11.002. Epub 2019 Dec 10.
142 Neutrophil extracellular traps activate lung fibroblast to induce polymyositis-related interstitial lung diseases via TLR9-miR-7-Smad2 pathway.J Cell Mol Med. 2020 Jan;24(2):1658-1669. doi: 10.1111/jcmm.14858. Epub 2019 Dec 10.
143 LOX/LOXL in pulmonary fibrosis: potential therapeutic targets.J Drug Target. 2019 Aug;27(7):790-796. doi: 10.1080/1061186X.2018.1550649. Epub 2018 Nov 29.
144 The serum level and significance of lysyl oxidase-like 2 in patients with rheumatoid arthritis-associated interstitial lung disease.Clin Rheumatol. 2018 Jan;37(1):193-198. doi: 10.1007/s10067-017-3878-0. Epub 2017 Oct 19.
145 The tumor necrosis factor family member LIGHT is a target for asthmatic airway remodeling.Nat Med. 2011 May;17(5):596-603. doi: 10.1038/nm.2356. Epub 2011 Apr 17.
146 A novel lnc-PCF promotes the proliferation of TGF-1-activated epithelial cells by targeting miR-344a-5p to regulate map3k11 in pulmonary fibrosis.Cell Death Dis. 2017 Oct 26;8(10):e3137. doi: 10.1038/cddis.2017.500.
147 Tackling MARCKS-PIP3 circuit attenuates fibroblast activation and fibrosis progression.FASEB J. 2019 Dec;33(12):14354-14369. doi: 10.1096/fj.201901705R. Epub 2019 Oct 26.
148 Early treatment with fumagillin, an inhibitor of methionine aminopeptidase-2, prevents Pulmonary Hypertension in monocrotaline-injured rats.PLoS One. 2012;7(4):e35388. doi: 10.1371/journal.pone.0035388. Epub 2012 Apr 11.
149 Matrix metalloproteinase-1 polymorphism (-1607G) and disease severity in non-cystic fibrosis bronchiectasis in Taiwan.PLoS One. 2013 Jun 11;8(6):e66265. doi: 10.1371/journal.pone.0066265. Print 2013.
150 Fructose-1,6-bisphosphate prevents pulmonary fibrosis by regulating extracellular matrix deposition and inducing phenotype reversal of lung myofibroblasts.PLoS One. 2019 Sep 11;14(9):e0222202. doi: 10.1371/journal.pone.0222202. eCollection 2019.
151 Lung collagens perpetuate pulmonary fibrosis via CD204 and M2 macrophage activation.PLoS One. 2013 Nov 20;8(11):e81382. doi: 10.1371/journal.pone.0081382. eCollection 2013.
152 Oral N-acetylcysteine reduces bleomycin-induced lung damage and mucin Muc5ac expression in rats.Eur Respir J. 2003 Dec;22(6):900-5. doi: 10.1183/09031936.03.00018003.
153 MLN4924 protects against bleomycin-induced pulmonary fibrosis by inhibiting the early inflammatory process.Am J Transl Res. 2017 Apr 15;9(4):1810-1821. eCollection 2017.
154 Rapamycin attenuates the paraquat-induced pulmonary fibrosis through activating Nrf2 pathway.J Cell Physiol. 2020 Feb;235(2):1759-1768. doi: 10.1002/jcp.29094. Epub 2019 Jul 12.
155 Carbon black nanoparticles induce pulmonary fibrosis through NLRP3 inflammasome pathway modulated by miR-96 targeted FOXO3a.Chemosphere. 2020 Feb;241:125075. doi: 10.1016/j.chemosphere.2019.125075. Epub 2019 Oct 11.
156 Cell type- and tissue-specific functions of ecto-5'-nucleotidase (CD73).Am J Physiol Cell Physiol. 2019 Dec 1;317(6):C1079-C1092. doi: 10.1152/ajpcell.00285.2019. Epub 2019 Aug 28.
157 The purinergic receptor subtype P2Y2 mediates chemotaxis of neutrophils and fibroblasts in fibrotic lung disease.Oncotarget. 2017 May 30;8(22):35962-35972. doi: 10.18632/oncotarget.16414.
158 MiR-541-5p regulates lung fibrosis by targeting cyclic nucleotide phosphodiesterase 1A.Exp Lung Res. 2017 Aug-Sep;43(6-7):249-258. doi: 10.1080/01902148.2017.1349210. Epub 2017 Aug 17.
159 Fatal pulmonary fibrosis associated with BCNU: the relative role of platelet-derived growth factor-B, insulin-like growth factor I, transforming growth factor-beta1 and cyclooxygenase-2. Bone Marrow Transplant. 2004 Oct;34(7):609-14. doi: 10.1038/sj.bmt.1704616.
160 Blockade of platelet-derived growth factor receptor-, not receptor- ameliorates bleomycin-induced pulmonary fibrosis in mice.PLoS One. 2018 Dec 31;13(12):e0209786. doi: 10.1371/journal.pone.0209786. eCollection 2018.
161 Inactivation of urokinase-type plasminogen activator receptor (uPAR) gene induces dermal and pulmonary fibrosis and peripheral microvasculopathy in mice: a new model of experimental scleroderma?.Ann Rheum Dis. 2014 Sep;73(9):1700-9. doi: 10.1136/annrheumdis-2013-203706. Epub 2013 Jul 12.
162 Glycogen Synthase Kinase-3 Inhibition with 9-ING-41 Attenuates the Progression of Pulmonary Fibrosis.Sci Rep. 2019 Dec 12;9(1):18925. doi: 10.1038/s41598-019-55176-w.
163 Cross-Talk between Transforming Growth Factor- and Periostin Can Be Targeted for Pulmonary Fibrosis.Am J Respir Cell Mol Biol. 2020 Feb;62(2):204-216. doi: 10.1165/rcmb.2019-0245OC.
164 Protein Tyrosine Phosphatase-N13 Promotes Myofibroblast Resistance to Apoptosis in Idiopathic Pulmonary Fibrosis.Am J Respir Crit Care Med. 2018 Oct 1;198(7):914-927. doi: 10.1164/rccm.201707-1497OC.
165 Upregulation of RGS2: a new mechanism for pirfenidone amelioration of pulmonary fibrosis.Respir Res. 2016 Aug 22;17(1):103. doi: 10.1186/s12931-016-0418-4.
166 Effectiveness of pulmonary rehabilitation in patients with interstitial lung disease of different etiology: a multicenter prospective study.BMC Pulm Med. 2017 Oct 10;17(1):130. doi: 10.1186/s12890-017-0476-5.
167 Genomic profile of matrix and vasculature remodeling in TGF-alpha induced pulmonary fibrosis.Am J Respir Cell Mol Biol. 2007 Sep;37(3):309-21. doi: 10.1165/rcmb.2006-0455OC. Epub 2007 May 11.
168 Expression of RXFP1 Is Decreased in Idiopathic Pulmonary Fibrosis. Implications for Relaxin-based Therapies.Am J Respir Crit Care Med. 2016 Dec 1;194(11):1392-1402. doi: 10.1164/rccm.201509-1865OC.
169 S100A4(+) Macrophages Are Necessary for Pulmonary Fibrosis by Activating Lung Fibroblasts.Front Immunol. 2018 Aug 6;9:1776. doi: 10.3389/fimmu.2018.01776. eCollection 2018.
170 Deficiency of Sphingosine-1-Phosphate Receptor 2 (S1P(2)) Attenuates Bleomycin-Induced Pulmonary Fibrosis.Biomol Ther (Seoul). 2019 May 1;27(3):318-326. doi: 10.4062/biomolther.2018.131.
171 S1PR3 deficiency alleviates radiation-induced pulmonary fibrosis through the regulation of epithelial-mesenchymal transition by targeting miR-495-3p.J Cell Physiol. 2020 Mar;235(3):2310-2324. doi: 10.1002/jcp.29138. Epub 2019 Sep 5.
172 Deficiency of Psgl-1 accelerates bleomycin (BLM)-induced lung fibrosis and inflammation in mice through activating PI3K/AKT.Biochem Biophys Res Commun. 2017 Sep 16;491(2):558-565. doi: 10.1016/j.bbrc.2017.03.003. Epub 2017 Mar 3.
173 Treatment of pulmonary fibrosis with siRNA against a collagen-specific chaperone HSP47 in vitamin A-coupled liposomes.Exp Lung Res. 2017 Aug-Sep;43(6-7):271-282. doi: 10.1080/01902148.2017.1354946. Epub 2017 Oct 16.
174 Identification and Characterizations of Novel, Selective Histone Methyltransferase SET7 Inhibitors by Scaffold Hopping- and 2D-Molecular Fingerprint-Based Similarity Search.Molecules. 2018 Mar 2;23(3):567. doi: 10.3390/molecules23030567.
175 Naftopidil reduced the proliferation of lung fibroblasts and bleomycin-induced lung fibrosis in mice.J Cell Mol Med. 2019 May;23(5):3563-3571. doi: 10.1111/jcmm.14255. Epub 2019 Mar 15.
176 Quercetin ameliorates pulmonary fibrosis by inhibiting SphK1/S1P signaling.Biochem Cell Biol. 2018 Dec;96(6):742-751. doi: 10.1139/bcb-2017-0302. Epub 2018 Jun 25.
177 Novel Insights on Systemic and Brain Aging, Stroke, Amyotrophic Lateral Sclerosis, and Alzheimer's Disease.Aging Dis. 2019 Apr 1;10(2):470-482. doi: 10.14336/AD.2019.0330. eCollection 2019 Apr.
178 Costunolide inhibits pulmonary fibrosis via regulating NF-kB and TGF-(1)/Smad(2)/Nrf(2)-NOX(4) signaling pathways.Biochem Biophys Res Commun. 2019 Mar 5;510(2):329-333. doi: 10.1016/j.bbrc.2019.01.104. Epub 2019 Jan 29.
179 Osteopontin lung gene expression is a marker of disease severity in pulmonary arterial hypertension.Respirology. 2019 Nov;24(11):1104-1110. doi: 10.1111/resp.13557. Epub 2019 Apr 8.
180 STAT1-dependent and -independent pulmonary allergic and fibrogenic responses in mice after exposure to tangled versus rod-like multi-walled carbon nanotubes.Part Fibre Toxicol. 2017 Jul 17;14(1):26. doi: 10.1186/s12989-017-0207-3.
181 Overexpression of Sulf2 in idiopathic pulmonary fibrosis.Glycobiology. 2013 Jun;23(6):709-19. doi: 10.1093/glycob/cwt010. Epub 2013 Feb 14.
182 Lung Transplant Outcomes in Patients With Pulmonary Fibrosis With Telomere-Related Gene Variants.Chest. 2019 Sep;156(3):477-485. doi: 10.1016/j.chest.2019.03.030. Epub 2019 Apr 9.
183 Longitudinal free-breathing MRI measurement of murine lung physiology in a progressive model of lung fibrosis.J Appl Physiol (1985). 2019 Apr 1;126(4):1138-1149. doi: 10.1152/japplphysiol.00993.2018. Epub 2019 Feb 7.
184 The CDR1as/miR-7/TGFBR2 Axis Modulates EMT in Silica-Induced Pulmonary Fibrosis.Toxicol Sci. 2018 Dec 1;166(2):465-478. doi: 10.1093/toxsci/kfy221.
185 TIAM1 inhibits lung fibroblast differentiation in pulmonary fibrosis.Exp Ther Med. 2017 Nov;14(5):4254-4262. doi: 10.3892/etm.2017.5024. Epub 2017 Aug 24.
186 BAX inhibitor-1-associated V-ATPase glycosylation enhances collagen degradation in pulmonary fibrosis.Cell Death Dis. 2014 Mar 13;5(3):e1113. doi: 10.1038/cddis.2014.86.
187 Human airway trypsin-like protease exerts potent, antifibrotic action in pulmonary fibrosis.FASEB J. 2018 Mar;32(3):1250-1264. doi: 10.1096/fj.201700583R. Epub 2018 Jan 3.
188 Anti-fibrotic effects of pirfenidone and rapamycin in primary IPF fibroblasts and human alveolar epithelial cells.BMC Pulm Med. 2018 Apr 27;18(1):63. doi: 10.1186/s12890-018-0626-4.
189 Localized expression of tenascin in systemic sclerosis-associated pulmonary fibrosis and its regulation by insulin-like growth factor binding protein 3.Arthritis Rheum. 2012 Jan;64(1):272-80. doi: 10.1002/art.30647.
190 Pathogenic roles of B lymphocytes in systemic sclerosis.Immunol Lett. 2018 Mar;195:76-82. doi: 10.1016/j.imlet.2018.01.002. Epub 2018 Jan 5.
191 Serotonin Exhibits Accelerated Bleomycin-Induced Pulmonary Fibrosis through TPH1 Knockout Mouse Experiments.Mediators Inflamm. 2018 Apr 16;2018:7967868. doi: 10.1155/2018/7967868. eCollection 2018.
192 Cdc42-interacting protein 4 silencing relieves pulmonary fibrosis in STZ-induced diabetic mice via the Wnt/GSK-3/-catenin pathway.Exp Cell Res. 2017 Oct 1;359(1):284-290. doi: 10.1016/j.yexcr.2017.07.018. Epub 2017 Jul 16.
193 Increased expression of lung TRPV1/TRPA1 in a cough model of bleomycin-induced pulmonary fibrosis in Guinea pigs.BMC Pulm Med. 2019 Feb 4;19(1):27. doi: 10.1186/s12890-019-0792-z.
194 Transient receptor potential (TRP) channels as molecular targets in lung toxicology and associated diseases.Cell Calcium. 2017 Nov;67:123-137. doi: 10.1016/j.ceca.2017.04.005. Epub 2017 Apr 26.
195 Macrophage-secreted TSLP and MMP9 promote bleomycin-induced pulmonary fibrosis.Toxicol Appl Pharmacol. 2019 Mar 1;366:10-16. doi: 10.1016/j.taap.2019.01.011. Epub 2019 Jan 14.
196 Pregnancy exposure to carbon black nanoparticles exacerbates bleomycin-induced lung fibrosis in offspring via disrupting LKB1-AMPK-ULK1 axis-mediated autophagy.Toxicology. 2019 Sep 1;425:152244. doi: 10.1016/j.tox.2019.152244. Epub 2019 Jul 11.
197 Distribution of von Willebrand factor in capillary endothelial cells of rat lungs with pulmonary fibrosis.Exp Toxicol Pathol. 1996 Jun;48(4):283-8. doi: 10.1016/S0940-2993(96)80020-0.
198 IL-37 Attenuates Lung Fibrosis by Inducing Autophagy and Regulating TGF-1 Production in Mice.J Immunol. 2019 Oct 15;203(8):2265-2275. doi: 10.4049/jimmunol.1801515. Epub 2019 Sep 13.
199 ABCA3 mutations led to pulmonary fibrosis and emphysema with pulmonary hypertension in an 8-year-old girl.Pediatr Pulmonol. 2016 Jun;51(6):E21-3. doi: 10.1002/ppul.23379. Epub 2016 Jan 18.
200 Annexin A11 is associated with pulmonary fibrosis in African American patients with sarcoidosis.Sarcoidosis Vasc Diffuse Lung Dis. 2016 Dec 23;33(4):418-422.
201 Bleomycin hydrolase and a genetic locus within the MHC affect risk for pulmonary fibrosis in mice.Hum Mol Genet. 2002 Aug 1;11(16):1855-63. doi: 10.1093/hmg/11.16.1855.
202 Dimethylarginine dimethylaminohydrolase 1 deficiency aggravates monocrotaline-induced pulmonary oxidative stress, pulmonary arterial hypertension and right heart failure in rats.Int J Cardiol. 2019 Nov 15;295:14-20. doi: 10.1016/j.ijcard.2019.07.078. Epub 2019 Jul 27.
203 Reduced expression of BMP3 contributes to the development of pulmonary fibrosis and predicts the unfavorable prognosis in IIP patients.Oncotarget. 2017 Aug 9;8(46):80531-80544. doi: 10.18632/oncotarget.20083. eCollection 2017 Oct 6.
204 In Situ Imaging of Tissue Remodeling with Collagen Hybridizing Peptides.ACS Nano. 2017 Oct 24;11(10):9825-9835. doi: 10.1021/acsnano.7b03150. Epub 2017 Sep 18.
205 Beclin 1, LC3, and p62 expression in paraquat-induced pulmonary fibrosis.Hum Exp Toxicol. 2019 Jul;38(7):794-802. doi: 10.1177/0960327119842633. Epub 2019 Apr 12.
206 A case report of heterozygous TINF2 gene mutation associated with pulmonary fibrosis in a patient with dyskeratosis congenita.Medicine (Baltimore). 2018 May;97(19):e0724. doi: 10.1097/MD.0000000000010724.
207 Increased circulating desmosine and age-dependent elastinolysis in idiopathic pulmonary fibrosis.Respir Res. 2018 Mar 20;19(1):45. doi: 10.1186/s12931-018-0747-6.
208 High expression of FAM13A was associated with increasing the liver cirrhosis risk.Mol Genet Genomic Med. 2019 Mar;7(3):e543. doi: 10.1002/mgg3.543. Epub 2019 Jan 2.
209 Association of HLA-DPB1 with scleroderma and its clinical features in Chinese population.PLoS One. 2014 Jan 31;9(1):e87363. doi: 10.1371/journal.pone.0087363. eCollection 2014.
210 Increased expression of latent TGF--binding protein 4 affects the fibrotic process in scleroderma by TGF-/SMAD signaling.Lab Invest. 2017 May;97(5):591-601. doi: 10.1038/labinvest.2017.20. Epub 2017 Mar 6.
211 Identification of periplakin as a major regulator of lung injury and repair in mice.JCI Insight. 2018 Mar 8;3(5):e90163. doi: 10.1172/jci.insight.90163.
212 Role of SOD3 in silica-related lung fibrosis and pulmonary vascular remodeling.Respir Res. 2018 Nov 20;19(1):221. doi: 10.1186/s12931-018-0933-6.
213 TMEM100 mediates inflammatory cytokines secretion in hepatic stellate cells and its mechanism research.Toxicol Lett. 2019 Dec 15;317:82-91. doi: 10.1016/j.toxlet.2018.12.010. Epub 2019 Jan 11.
214 miR-142-5p and miR-130a-3p are regulated by IL-4 and IL-13 and control profibrogenic macrophage program.Nat Commun. 2015 Oct 5;6:8523. doi: 10.1038/ncomms9523.
215 Cleavage factor 25 deregulation contributes to pulmonary fibrosis through alternative polyadenylation.J Clin Invest. 2019 Feb 28;129(5):1984-1999. doi: 10.1172/JCI122106. Print 2019 May 1.
216 Pirfenidone attenuates lung fibrotic fibroblast responses to transforming growth factor-1.Respir Res. 2019 Jun 11;20(1):119. doi: 10.1186/s12931-019-1093-z.
217 CXCL16/CXCR6 axis promotes bleomycin-induced fibrotic process in MRC-5 cells via the PI3K/AKT/FOXO3a pathway.Int Immunopharmacol. 2020 Apr;81:106035. doi: 10.1016/j.intimp.2019.106035. Epub 2019 Nov 19.
218 A Novel Variant of Desmoplakin Is Potentially Associated with Silicosis Risk.DNA Cell Biol. 2018 Nov;37(11):925-931. doi: 10.1089/dna.2018.4370. Epub 2018 Sep 12.
219 The effects of atorvastatin on the kidney injury in mice with pulmonary fibrosis.J Pharm Pharmacol. 2019 Aug;71(8):1301-1310. doi: 10.1111/jphp.13128. Epub 2019 Jun 18.
220 Involvement of GPx4-Regulated Lipid Peroxidation in Idiopathic Pulmonary Fibrosis Pathogenesis.J Immunol. 2019 Oct 15;203(8):2076-2087. doi: 10.4049/jimmunol.1801232. Epub 2019 Sep 18.
221 A novel mutation causes Hermansky-Pudlak syndrome type 4 with pulmonary fibrosis in 2 siblings from China.Medicine (Baltimore). 2019 Aug;98(33):e16899. doi: 10.1097/MD.0000000000016899.
222 Interleukin-18 promotes fibroblast senescence in pulmonary fibrosis through down-regulating Klotho expression.Biomed Pharmacother. 2019 May;113:108756. doi: 10.1016/j.biopha.2019.108756. Epub 2019 Mar 11.
223 The association of LAMB1 polymorphism and expression changes with the risk of coal workers' pneumoconiosis.Environ Toxicol. 2017 Sep;32(9):2182-2190. doi: 10.1002/tox.22431. Epub 2017 Apr 26.
224 Lysocardiolipin acyltransferase regulates TGF- mediated lung fibroblast differentiation.Free Radic Biol Med. 2017 Nov;112:162-173. doi: 10.1016/j.freeradbiomed.2017.07.023. Epub 2017 Jul 24.
225 Lysyl Oxidase-Like 1 Protein Deficiency Protects Mice from Adenoviral Transforming Growth Factor-1-induced Pulmonary Fibrosis.Am J Respir Cell Mol Biol. 2018 Apr;58(4):461-470. doi: 10.1165/rcmb.2017-0252OC.
226 Susceptibility of microtubule-associated protein 1 light chain 3 (MAP1LC3B/LC3B) knockout mice to lung injury and fibrosis.FASEB J. 2019 Nov;33(11):12392-12408. doi: 10.1096/fj.201900854R. Epub 2019 Aug 20.
227 Therapeutic effects of scavenger receptor MARCO ligand on silica-induced pulmonary fibrosis in rats.Toxicol Lett. 2019 Sep 1;311:1-10. doi: 10.1016/j.toxlet.2019.04.026. Epub 2019 Apr 24.
228 Mitochondrial calcium uniporter regulates PGC-1 expression to mediate metabolic reprogramming in pulmonary fibrosis.Redox Biol. 2019 Sep;26:101307. doi: 10.1016/j.redox.2019.101307. Epub 2019 Aug 25.
229 Augmented production of chemokines (monocyte chemotactic protein-1 (MCP-1), macrophage inflammatory protein-1alpha (MIP-1alpha) and MIP-1beta) in patients with systemic sclerosis: MCP-1 and MIP-1alpha may be involved in the development of pulmonary fibrosis.Clin Exp Immunol. 1999 Jul;117(1):159-65. doi: 10.1046/j.1365-2249.1999.00929.x.
230 P311 Promotes Lung Fibrosis via Stimulation of Transforming Growth Factor-1, -2, and -3 Translation.Am J Respir Cell Mol Biol. 2019 Feb;60(2):221-231. doi: 10.1165/rcmb.2018-0028OC.
231 A homozygous SFTPA1 mutation drives necroptosis of type II alveolar epithelial cells in patients with idiopathic pulmonary fibrosis.J Exp Med. 2019 Dec 2;216(12):2724-2735. doi: 10.1084/jem.20182351. Epub 2019 Oct 10.
232 A Human Gain-of-Function STING Mutation Causes Immunodeficiency and Gammaherpesvirus-Induced Pulmonary Fibrosis in Mice.J Virol. 2019 Feb 5;93(4):e01806-18. doi: 10.1128/JVI.01806-18. Print 2019 Feb 15.
233 Cell-surface translocation of annexin A2 contributes to bleomycin-induced pulmonary fibrosis by mediating inflammatory response in mice.Clin Sci (Lond). 2019 Apr 15;133(7):789-804. doi: 10.1042/CS20180687.
234 Classification of Genes: Standardized Clinical Validity Assessment of Gene-Disease Associations Aids Diagnostic Exome Analysis and Reclassifications. Hum Mutat. 2017 May;38(5):600-608. doi: 10.1002/humu.23183. Epub 2017 Feb 13.
235 Tetraspanin 1 as a mediator of fibrosis inhibits EMT process and Smad2/3 and beta-catenin pathway in human pulmonary fibrosis.J Cell Mol Med. 2019 May;23(5):3583-3596. doi: 10.1111/jcmm.14258. Epub 2019 Mar 14.
236 Angiotensin-converting enzyme defines matrikine-regulated inflammation and fibrosis.JCI Insight. 2017 Nov 16;2(22):e91923. doi: 10.1172/jci.insight.91923. eCollection 2017 Nov 16.
237 The atypical chemokine receptor ACKR2 drives pulmonary fibrosis by tuning influx of CCR2(+) and CCR5(+) IFN-producing T cells in mice.Am J Physiol Lung Cell Mol Physiol. 2018 Jun 1;314(6):L1010-L1025. doi: 10.1152/ajplung.00233.2017. Epub 2018 Feb 22.
238 Cell-surface phenotyping identifies CD36 and CD97 as novel markers of fibroblast quiescence in lung fibrosis.Am J Physiol Lung Cell Mol Physiol. 2018 Nov 1;315(5):L682-L696. doi: 10.1152/ajplung.00439.2017. Epub 2018 Jun 28.
239 Aortic carboxypeptidase-like protein is expressed in fibrotic human lung and its absence protects against bleomycin-induced lung fibrosis.Am J Pathol. 2009 Mar;174(3):818-28. doi: 10.2353/ajpath.2009.080856. Epub 2009 Jan 29.
240 Cross talk between Id1 and its interactive protein Dril1 mediate fibroblast responses to transforming growth factor-beta in pulmonary fibrosis.Am J Pathol. 2008 Aug;173(2):337-46. doi: 10.2353/ajpath.2008.070915. Epub 2008 Jun 26.
241 Senolytic drugs targetalveolar epithelial cell function and attenuate experimental lung fibrosis ex vivo.Eur Respir J. 2017 Aug 3;50(2):1602367. doi: 10.1183/13993003.02367-2016. Print 2017 Aug.
242 Autophagy induction by celastrol augments protection against bleomycin-induced experimental pulmonary fibrosis in rats: Role of adaptor protein p62/ SQSTM1.Pulm Pharmacol Ther. 2017 Aug;45:47-61. doi: 10.1016/j.pupt.2017.04.003. Epub 2017 Apr 4.
243 Impaired autophagic activity and ATG4B deficiency are associated with increased endoplasmic reticulum stress-induced lung injury.Aging (Albany NY). 2018 Aug 27;10(8):2098-2112. doi: 10.18632/aging.101532.
244 Evaluation of Renin and Soluble (Pro)renin Receptor in Patients with IPF. A Comparison with Hypersensitivity Pneumonitis.Lung. 2019 Dec;197(6):715-720. doi: 10.1007/s00408-019-00278-5. Epub 2019 Oct 15.
245 Oxidative stress induces club cell proliferation and pulmonary fibrosis in Atp8b1 mutant mice.Aging (Albany NY). 2019 Jan 13;11(1):209-229. doi: 10.18632/aging.101742.
246 Glycosyltransferases and glycosaminoglycans in bleomycin and transforming growth factor-1-induced pulmonary fibrosis.Am J Respir Cell Mol Biol. 2014 Mar;50(3):583-94. doi: 10.1165/rcmb.2012-0226OC.
247 Increased deposition of chondroitin/dermatan sulfate glycosaminoglycan and upregulation of 1,3-glucuronosyltransferase I in pulmonary fibrosis.Am J Physiol Lung Cell Mol Physiol. 2011 Feb;300(2):L191-203. doi: 10.1152/ajplung.00214.2010. Epub 2010 Nov 5.
248 Novel and extensive aspects of paraquat-induced pulmonary fibrogenesis: comparative and time-course microarray analyses in fibrogenic and non-fibrogenic rats.J Toxicol Sci. 2007 Dec;32(5):529-53. doi: 10.2131/jts.32.529.
249 BARD1 mediates TGF- signaling in pulmonary fibrosis.Respir Res. 2015 Sep 29;16:118. doi: 10.1186/s12931-015-0278-3.
250 Antifibrotic action of Yifei Sanjie formula enhanced autophagy via PI3K-AKT-mTOR signaling pathway in mouse model of pulmonary fibrosis.Biomed Pharmacother. 2019 Oct;118:109293. doi: 10.1016/j.biopha.2019.109293. Epub 2019 Aug 8.
251 Calpain 9 as a therapeutic target in TGF-induced mesenchymal transition and fibrosis.Sci Transl Med. 2019 Jul 17;11(501):eaau2814. doi: 10.1126/scitranslmed.aau2814.
252 The calpain inhibitor calpeptin prevents bleomycin-induced pulmonary fibrosis in mice.Clin Exp Immunol. 2010 Dec;162(3):560-7. doi: 10.1111/j.1365-2249.2010.04257.x. Epub 2010 Sep 15.
253 CBX5/G9a/H3K9me-mediated gene repression is essential to fibroblast activation during lung fibrosis.JCI Insight. 2019 May 16;5(12):e127111. doi: 10.1172/jci.insight.127111.
254 Performance of Candidate Serum Biomarkers for Systemic Sclerosis-Associated Interstitial Lung Disease.Arthritis Rheumatol. 2019 Jun;71(6):972-982. doi: 10.1002/art.40815. Epub 2019 Apr 26.
255 Blockade of CCL24 with a monoclonal antibody ameliorates experimental dermal and pulmonary fibrosis.Ann Rheum Dis. 2019 Sep;78(9):1260-1268. doi: 10.1136/annrheumdis-2019-215119. Epub 2019 May 25.
256 WISP1 mediates IL-6-dependent proliferation in primary human lung fibroblasts.Sci Rep. 2016 Feb 12;6:20547. doi: 10.1038/srep20547.
257 CCN5 overexpression inhibits profibrotic phenotypes via the PI3K/Akt signaling pathway in lung fibroblasts isolated from patients with idiopathic pulmonary fibrosis and in an in vivo model of lung fibrosis.Int J Mol Med. 2014 Feb;33(2):478-86. doi: 10.3892/ijmm.2013.1565. Epub 2013 Nov 25.
258 WISP3 prevents fibroblast-myofibroblast transdifferentiation in NRK-49F cells.Biomed Pharmacother. 2018 Mar;99:306-312. doi: 10.1016/j.biopha.2018.01.005.
259 CCR10+ epithelial cells from idiopathic pulmonary fibrosis lungs drive remodeling.JCI Insight. 2018 Aug 23;3(16):e122211. doi: 10.1172/jci.insight.122211. eCollection 2018 Aug 23.
260 Tetraspanin CD151 protects against pulmonary fibrosis by maintaining epithelial integrity.Am J Respir Crit Care Med. 2012 Jul 15;186(2):170-80. doi: 10.1164/rccm.201201-0117OC. Epub 2012 May 16.
261 Cub domain-containing protein 1 negatively regulates TGF- signaling and myofibroblast differentiation.Am J Physiol Lung Cell Mol Physiol. 2018 May 1;314(5):L695-L707. doi: 10.1152/ajplung.00205.2017. Epub 2018 Jan 4.
262 Triptolide protects against TGF-1-induced pulmonary fibrosis by regulating FAK/calpain signaling.Exp Ther Med. 2019 Dec;18(6):4781-4789. doi: 10.3892/etm.2019.8127. Epub 2019 Oct 25.
263 Cysteine-rich protein 1 is regulated by transforming growth factor-1 and expressed in lung fibrosis.J Cell Physiol. 2012 Jun;227(6):2605-12. doi: 10.1002/jcp.23000.
264 Therapeutic effect of ulinastatin on pulmonary fibrosis via downregulation of TGF?, TNF?and NFB.Mol Med Rep. 2018 Jan;17(1):1717-1723. doi: 10.3892/mmr.2017.8056. Epub 2017 Nov 14.
265 Antifibrotic properties of caveolin-1 scaffolding domain in vitro and in vivo.Am J Physiol Lung Cell Mol Physiol. 2008 May;294(5):L843-61. doi: 10.1152/ajplung.00295.2007. Epub 2008 Jan 18.
266 Localized hypoxia links ER stress to lung fibrosis through induction of C/EBP homologous protein.JCI Insight. 2018 Aug 23;3(16):e99543. doi: 10.1172/jci.insight.99543. eCollection 2018 Aug 23.
267 NADPH Oxidases and Aging Models of Lung Fibrosis.Methods Mol Biol. 2019;1982:487-496. doi: 10.1007/978-1-4939-9424-3_29.
268 Thyroid hormone inhibits lung fibrosis in mice by improving epithelial mitochondrial function.Nat Med. 2018 Jan;24(1):39-49. doi: 10.1038/nm.4447. Epub 2017 Dec 4.
269 The profibrotic effect of downregulated Na,KATPase 1 subunit in alveolar epithelial cells during lung fibrosis.Int J Mol Med. 2019 Jul;44(1):273-280. doi: 10.3892/ijmm.2019.4201. Epub 2019 May 16.
270 Pharmacological targeting of BET proteins attenuates radiation-induced lung fibrosis.Sci Rep. 2018 Jan 17;8(1):998. doi: 10.1038/s41598-018-19343-9.
271 Overexpressing p130/E2F4 in mesenchymal stem cells facilitates the repair of injured alveolar epithelial cells in LPS-induced ARDS mice.Stem Cell Res Ther. 2019 Mar 6;10(1):74. doi: 10.1186/s13287-019-1169-1.
272 Associations of Pulmonary Fibrosis with Peripheral Blood Th1/Th2 Cell Imbalance and EBF3 Gene Methylation in Uygur Pigeon Breeder's Lung Patients.Cell Physiol Biochem. 2018;47(3):1141-1151. doi: 10.1159/000490208. Epub 2018 Jun 15.
273 The Oncogene ECT2 Contributes to a Hyperplastic, Proliferative Lung Epithelial Cell Phenotype in Idiopathic Pulmonary Fibrosis.Am J Respir Cell Mol Biol. 2019 Dec;61(6):713-726. doi: 10.1165/rcmb.2019-0047OC.
274 Inhibitory effect of l-mimosine on bleomycin-induced pulmonary fibrosis in rats: Role of eIF3a and p27.Int Immunopharmacol. 2015 Jul;27(1):53-64. doi: 10.1016/j.intimp.2015.04.048. Epub 2015 May 5.
275 ELMOD2 is a candidate gene for familial idiopathic pulmonary fibrosis.Am J Hum Genet. 2006 Jul;79(1):149-54. doi: 10.1086/504639. Epub 2006 May 9.
276 Deranged fatty acid composition causes pulmonary fibrosis in Elovl6-deficient mice.Nat Commun. 2013;4:2563. doi: 10.1038/ncomms3563.
277 Shared and Tissue-Specific Expression Signatures between Bone Marrow from Primary Myelofibrosis and Essential Thrombocythemia.Exp Hematol. 2019 Nov;79:16-25.e3. doi: 10.1016/j.exphem.2019.10.001. Epub 2019 Nov 1.
278 Family of hereditary fibrosing poikiloderma with tendon contractures, myopathy and pulmonary fibrosis caused by a novel FAM111B mutation.J Dermatol. 2019 Nov;46(11):1014-1018. doi: 10.1111/1346-8138.15045. Epub 2019 Aug 7.
279 Therapeutic effect of a peptide inhibitor of TGF- on pulmonary fibrosis.Cytokine. 2011 Mar;53(3):327-33. doi: 10.1016/j.cyto.2010.11.019. Epub 2010 Dec 23.
280 Ethnicity and race and systemic sclerosis: how it affects susceptibility, severity, antibody genetics, and clinical manifestations.Curr Rheumatol Rep. 2003 Apr;5(2):160-7. doi: 10.1007/s11926-003-0045-1.
281 Identification of molecular signatures involved in radiation-induced lung fibrosis.J Mol Med (Berl). 2019 Jan;97(1):37-47. doi: 10.1007/s00109-018-1715-9. Epub 2018 Nov 7.
282 The FMS-like tyrosine kinase-3 ligand/lung dendritic cell axis contributes to regulation of pulmonary fibrosis.Thorax. 2019 Oct;74(10):947-957. doi: 10.1136/thoraxjnl-2018-212603. Epub 2019 May 10.
283 FOXF1 Inhibits Pulmonary Fibrosis by Preventing CDH2-CDH11 Cadherin Switch in Myofibroblasts.Cell Rep. 2018 Apr 10;23(2):442-458. doi: 10.1016/j.celrep.2018.03.067.
284 Haplodeletion of Follistatin-Like 1 Attenuates Radiation-Induced Pulmonary Fibrosis in Mice.Int J Radiat Oncol Biol Phys. 2019 Jan 1;103(1):208-216. doi: 10.1016/j.ijrobp.2018.08.035. Epub 2018 Aug 29.
285 The effect of core fucosylation-mediated regulation of multiple signaling pathways on lung pericyte activation and fibrosis.Int J Biochem Cell Biol. 2019 Dec;117:105639. doi: 10.1016/j.biocel.2019.105639. Epub 2019 Oct 24.
286 Increased levels of Gab1 and Gab2 adaptor proteins skew interleukin-4 (IL-4) signaling toward M2 macrophage-driven pulmonary fibrosis in mice.J Biol Chem. 2017 Aug 25;292(34):14003-14015. doi: 10.1074/jbc.M117.802066. Epub 2017 Jul 7.
287 Geranylgeranyl diphosphate synthase deficiency aggravates lung fibrosis in mice by modulating TGF-1/BMP-4 signaling.Biol Chem. 2019 Nov 26;400(12):1617-1627. doi: 10.1515/hsz-2019-0168.
288 Effects of dynamic changes in histone acetylation and deacetylase activity on pulmonary fibrosis.Int Immunopharmacol. 2017 Nov;52:272-280. doi: 10.1016/j.intimp.2017.09.020. Epub 2017 Sep 27.
289 Changes in factor VII-activating protease in a bleomycin-induced lung injury rat model and its influence on human pulmonary fibroblasts in vitro.Int J Mol Med. 2010 Oct;26(4):549-55. doi: 10.3892/ijmm_00000498.
290 Protocatechuic aldehyde ameliorates experimental pulmonary fibrosis by modulating HMGB1/RAGE pathway.Toxicol Appl Pharmacol. 2015 Feb 15;283(1):50-6. doi: 10.1016/j.taap.2015.01.001. Epub 2015 Jan 9.
291 Dysregulated Lung Commensal Bacteria Drive Interleukin-17B Production to Promote Pulmonary Fibrosis through Their Outer Membrane Vesicles.Immunity. 2019 Mar 19;50(3):692-706.e7. doi: 10.1016/j.immuni.2019.02.001. Epub 2019 Feb 26.
292 Expression of HIF-1A/VEGF/ING-4 Axis in Pulmonary Sarcoidosis.Adv Exp Med Biol. 2015;866:61-9. doi: 10.1007/5584_2015_144.
293 The MUC5B promoter polymorphism is associated with idiopathic pulmonary fibrosis in a Mexican cohort but is rare among Asian ancestries.Chest. 2015 Feb;147(2):460-464. doi: 10.1378/chest.14-0867.
294 Herbal decoctosome is a novel form of medicine.Sci China Life Sci. 2019 Mar;62(3):333-348. doi: 10.1007/s11427-018-9508-0. Epub 2019 Mar 21.
295 The Role of KCNMB1 and BK Channels in Myofibroblast Differentiation and Pulmonary Fibrosis.Am J Respir Cell Mol Biol. 2020 Feb;62(2):191-203. doi: 10.1165/rcmb.2019-0163OC.
296 Nrf2 amplifies oxidative stress via induction of Klf9.Mol Cell. 2014 Mar 20;53(6):916-928. doi: 10.1016/j.molcel.2014.01.033. Epub 2014 Mar 6.
297 Laminin 1 is a genetic modifier of TGF-1-stimulated pulmonary fibrosis.JCI Insight. 2018 Sep 20;3(18):e99574. doi: 10.1172/jci.insight.99574. eCollection 2018 Sep 20.
298 Identification and Optimization of Mechanism-Based Fluoroallylamine Inhibitors of Lysyl Oxidase-like 2/3.J Med Chem. 2019 Nov 14;62(21):9874-9889. doi: 10.1021/acs.jmedchem.9b01283. Epub 2019 Oct 16.
299 Mitofusins regulate lipid metabolism to mediate the development of lung fibrosis.Nat Commun. 2019 Jul 29;10(1):3390. doi: 10.1038/s41467-019-11327-1.
300 TRAIL signals through the ubiquitin ligase MID1 to promote pulmonary fibrosis.BMC Pulm Med. 2019 Feb 7;19(1):31. doi: 10.1186/s12890-019-0786-x.
301 Matrix metalloproteinase-19 is a key regulator of lung fibrosis in mice and humans.Am J Respir Crit Care Med. 2012 Oct 15;186(8):752-62. doi: 10.1164/rccm.201202-0302OC. Epub 2012 Aug 2.
302 Identification of MMP28 as a biomarker for the differential diagnosis of idiopathic pulmonary fibrosis.PLoS One. 2018 Sep 12;13(9):e0203779. doi: 10.1371/journal.pone.0203779. eCollection 2018.
303 Developmental pathways in the pathogenesis of lung fibrosis.Mol Aspects Med. 2019 Feb;65:56-69. doi: 10.1016/j.mam.2018.08.004. Epub 2018 Aug 23.
304 Amplified canonical transforming growth factor- signalling via heat shock protein 90 in pulmonary fibrosis.Eur Respir J. 2017 Feb 23;49(2):1501941. doi: 10.1183/13993003.01941-2015. Print 2017 Feb.
305 Inhibition of mechanosensitive signaling in myofibroblasts ameliorates experimental pulmonary fibrosis.J Clin Invest. 2013 Mar;123(3):1096-108. doi: 10.1172/JCI66700. Epub 2013 Feb 22.
306 Transplantation of adipose-derived mesenchymal stem cells attenuates pulmonary fibrosis of silicosis via anti-inflammatory and anti-apoptosis effects in rats.Stem Cell Res Ther. 2018 Apr 19;9(1):110. doi: 10.1186/s13287-018-0846-9.
307 Attenuated pulmonary fibrosis in sialidase-3 knockout (Neu3(-/-)) mice.Am J Physiol Lung Cell Mol Physiol. 2020 Jan 1;318(1):L165-L179. doi: 10.1152/ajplung.00275.2019. Epub 2019 Oct 16.
308 Ninjurin1 Plays a Crucial Role in Pulmonary Fibrosis by Promoting Interaction between Macrophages and Alveolar Epithelial Cells.Sci Rep. 2018 Dec 3;8(1):17542. doi: 10.1038/s41598-018-35997-x.
309 Nkx2.5/Csx represses myofibroblast differentiation.Am J Respir Cell Mol Biol. 2010 Feb;42(2):218-26. doi: 10.1165/rcmb.2008-0404OC. Epub 2009 Apr 24.
310 Role of Nephronectin in Pathophysiology of Silicosis.Int J Mol Sci. 2019 May 26;20(10):2581. doi: 10.3390/ijms20102581.
311 Tenofovir alafenamide fumarate attenuates bleomycin-induced pulmonary fibrosis by upregulating the NS5ATP9 and TGF-1/Smad3 signaling pathway.Respir Res. 2019 Jul 22;20(1):163. doi: 10.1186/s12931-019-1102-2.
312 PGAM5 is a key driver of mitochondrial dysfunction in experimental lung fibrosis.Cell Mol Life Sci. 2019 Dec;76(23):4783-4794. doi: 10.1007/s00018-019-03133-1. Epub 2019 Jun 5.
313 Anti-inflammatory and anti-fibrotic effects of intravenous adipose-derived stem cell transplantation in a mouse model of bleomycin-induced interstitial pneumonia.Sci Rep. 2017 Nov 6;7(1):14608. doi: 10.1038/s41598-017-15022-3.
314 PINK1 attenuates mtDNA release in alveolar epithelial cells and TLR9 mediated profibrotic responses.PLoS One. 2019 Jun 6;14(6):e0218003. doi: 10.1371/journal.pone.0218003. eCollection 2019.
315 Histological hallmarks and role of Slug/PIP axis in pulmonary hypertension secondary to pulmonary fibrosis.EMBO Mol Med. 2019 Sep;11(9):e10061. doi: 10.15252/emmm.201810061. Epub 2019 Aug 29.
316 Plexin C1 deficiency permits synaptotagmin 7-mediated macrophage migration and enhances mammalian lung fibrosis.FASEB J. 2016 Dec;30(12):4056-4070. doi: 10.1096/fj.201600373R. Epub 2016 Sep 8.
317 Transcriptional regulatory model of fibrosis progression in the human lung.JCI Insight. 2019 Nov 14;4(22):e131597. doi: 10.1172/jci.insight.131597.
318 CircRNA-012091/PPP1R13B-mediated Lung Fibrotic Response in Silicosis via Endoplasmic Reticulum Stress and Autophagy.Am J Respir Cell Mol Biol. 2019 Sep;61(3):380-391. doi: 10.1165/rcmb.2019-0017OC.
319 Citrus Alkaline Extract Delayed the Progression of Pulmonary Fibrosis by Inhibiting p38/NF-B Signaling Pathway-Induced Cell Apoptosis.Evid Based Complement Alternat Med. 2019 Feb 4;2019:1528586. doi: 10.1155/2019/1528586. eCollection 2019.
320 Wedelolactone Attenuates Pulmonary Fibrosis Partly Through Activating AMPK and Regulating Raf-MAPKs Signaling Pathway.Front Pharmacol. 2019 Mar 5;10:151. doi: 10.3389/fphar.2019.00151. eCollection 2019.
321 Expression of Peroxiredoxins and Pulmonary Surfactant Protein A Induced by Silica in Rat Lung Tissue.Biomed Environ Sci. 2016 Aug;29(8):584-588. doi: 10.3967/bes2016.077.
322 The role of pentraxin-3 as a prognostic biomarker in paraquat poisoning.Toxicol Lett. 2012 Jul 20;212(2):157-60. doi: 10.1016/j.toxlet.2011.12.007. Epub 2011 Dec 22.
323 Rac2 is required for alternative macrophage activation and bleomycin induced pulmonary fibrosis; a macrophage autonomous phenotype.PLoS One. 2017 Aug 17;12(8):e0182851. doi: 10.1371/journal.pone.0182851. eCollection 2017.
324 Regulation of myofibroblast differentiation and bleomycin-induced pulmonary fibrosis by adrenomedullin.Am J Physiol Lung Cell Mol Physiol. 2013 Jun 1;304(11):L757-64. doi: 10.1152/ajplung.00262.2012. Epub 2013 Apr 12.
325 lncRNAPCAT29 inhibits pulmonary fibrosis via the TGF?regulated RASAL1/ERK1/2 signal pathway.Mol Med Rep. 2018 Jun;17(6):7781-7788. doi: 10.3892/mmr.2018.8807. Epub 2018 Mar 28.
326 Hypocrea peltata: a mycological Dr Jekyll and Mr Hyde?.Mycologia. 2011 May-Jun;103(3):616-30. doi: 10.3852/10-227. Epub 2011 Jan 24.
327 Reticulocalbin 3 Deficiency in Alveolar Epithelium Exacerbated Bleomycin-induced Pulmonary Fibrosis.Am J Respir Cell Mol Biol. 2018 Sep;59(3):320-333. doi: 10.1165/rcmb.2017-0347OC.
328 FIZZ2/RELM- induction and role in pulmonary fibrosis.J Immunol. 2011 Jul 1;187(1):450-61. doi: 10.4049/jimmunol.1000964. Epub 2011 May 20.
329 The novel inhibitor PRI-724 for Wnt/-catenin/CBP signaling ameliorates bleomycin-induced pulmonary fibrosis in mice.Exp Lung Res. 2019 Sep;45(7):188-199. doi: 10.1080/01902148.2019.1638466. Epub 2019 Jul 12.
330 Reactive oxygen species modulator 1 regulates oxidative stress and induces renal and pulmonary fibrosis in a unilateral ureteral obstruction rat model and in HK? cells.Mol Med Rep. 2017 Oct;16(4):4855-4862. doi: 10.3892/mmr.2017.7161. Epub 2017 Aug 3.
331 Early upregulation of acute respiratory distress syndrome-associated cytokines promotes lethal disease in an aged-mouse model of severe acute respiratory syndrome coronavirus infection.J Virol. 2009 Jul;83(14):7062-74. doi: 10.1128/JVI.00127-09. Epub 2009 May 6.
332 Secretoglobin 3A2 suppresses bleomycin-induced pulmonary fibrosis by transforming growth factor beta signaling down-regulation.J Biol Chem. 2011 Jun 3;286(22):19682-92. doi: 10.1074/jbc.M111.239046. Epub 2011 Apr 10.
333 Syndecan-4 Inhibits the Development of Pulmonary Fibrosis by Attenuating TGF- Signaling.Int J Mol Sci. 2019 Oct 9;20(20):4989. doi: 10.3390/ijms20204989.
334 Semaphorin 4A enhances lung fibrosis through activation of Akt via PlexinD1 receptor.J Biosci. 2015 Dec;40(5):855-62. doi: 10.1007/s12038-015-9566-9.
335 Endogenous Semaphorin-7A Impedes Human Lung Fibroblast Differentiation.PLoS One. 2017 Jan 17;12(1):e0170207. doi: 10.1371/journal.pone.0170207. eCollection 2017.
336 Hematopoietic protease nexin-1 protects against lung injury by preventing thrombin signaling in mice.Blood Adv. 2018 Sep 25;2(18):2389-2399. doi: 10.1182/bloodadvances.2018018283.
337 Epigallocatechin-3-gallate (EGCG) inhibits aggregation of pulmonary fibrosis associated mutant surfactant protein A2 via a proteasomal degradation pathway.Int J Biochem Cell Biol. 2019 Nov;116:105612. doi: 10.1016/j.biocel.2019.105612. Epub 2019 Sep 20.
338 Invitro expansion of endogenous human alveolar epithelial type II cells in fibroblast-free spheroid culture.Biochem Biophys Res Commun. 2019 Aug 6;515(4):579-585. doi: 10.1016/j.bbrc.2019.05.187. Epub 2019 Jun 6.
339 Sirtuin 7 is decreased in pulmonary fibrosis and regulates the fibrotic phenotype of lung fibroblasts.Am J Physiol Lung Cell Mol Physiol. 2017 Jun 1;312(6):L945-L958. doi: 10.1152/ajplung.00473.2016. Epub 2017 Apr 6.
340 Abrogation of transforming growth factor--induced tissue fibrosis in TBRIcaCol1a2Cre transgenic mice by the second generation tyrosine kinase inhibitor SKI-606 (Bosutinib).PLoS One. 2018 May 2;13(5):e0196559. doi: 10.1371/journal.pone.0196559. eCollection 2018.
341 Docosahexaenoic acid (DHA) ameliorates paraquat-induced pulmonary fibrosis in rats possibly through up-regulation of Smad 7 and SnoN.Food Chem Toxicol. 2013 Jul;57:330-7. doi: 10.1016/j.fct.2013.03.045. Epub 2013 Apr 13.
342 Protective effects of GHK-Cu in bleomycin-induced pulmonary fibrosis via anti-oxidative stress and anti-inflammation pathways.Life Sci. 2020 Jan 15;241:117139. doi: 10.1016/j.lfs.2019.117139. Epub 2019 Dec 4.
343 Effects of curcumin on artery blood gas index of rats with pulmonary fibrosis caused by paraquat poisoning and the expression of Smad 4, Smurf 2, interleukin-4 and interferon-.Exp Ther Med. 2019 May;17(5):3664-3670. doi: 10.3892/etm.2019.7341. Epub 2019 Mar 4.
344 Suppression of SMOC2 reduces bleomycin (BLM)-induced pulmonary fibrosis by inhibition of TGF-1/SMADs pathway.Biomed Pharmacother. 2018 Sep;105:841-847. doi: 10.1016/j.biopha.2018.03.058. Epub 2018 Jun 18.
345 Cell-penetrating peptides selectively targeting SMAD3 inhibit profibrotic TGF- signaling.J Clin Invest. 2017 Jun 30;127(7):2541-2554. doi: 10.1172/JCI88696. Epub 2017 May 22.
346 Imbalance in the pro-hepatocyte growth factor activation system in bleomycin-induced lung fibrosis in mice.Am J Respir Cell Mol Biol. 2010 Mar;42(3):286-93. doi: 10.1165/rcmb.2008-0305OC. Epub 2009 May 15.
347 Epimorphin expression in interstitial pneumonia.Respir Res. 2005 Jan 16;6(1):6. doi: 10.1186/1465-9921-6-6.
348 Epigenetic regulation of cyclooxygenase-2 by methylation of c8orf4 in pulmonary fibrosis.Clin Sci (Lond). 2016 Apr;130(8):575-86. doi: 10.1042/CS20150697. Epub 2016 Jan 7.
349 Up-regulation of THY1 attenuates interstitial pulmonary fibrosis and promotes lung fibroblast apoptosis during acute interstitial pneumonia by blockade of the WNT signaling pathway.Cell Cycle. 2019 Mar-Apr;18(6-7):670-681. doi: 10.1080/15384101.2019.1578144. Epub 2019 Mar 4.
350 P27 Promotes TGF--Mediated Pulmonary Fibrosis via Interacting with MTORC2.Can Respir J. 2019 Sep 19;2019:7157861. doi: 10.1155/2019/7157861. eCollection 2019.
351 TM4SF5-mediated CD44v8-10 splicing variant promotes survival of type II alveolar epithelial cells during idiopathic pulmonary fibrosis.Cell Death Dis. 2019 Sep 9;10(9):645. doi: 10.1038/s41419-019-1878-5.
352 Transmembrane protease, serine 4 (TMPRSS4) is upregulated in IPF lungs and increases the fibrotic response in bleomycin-induced lung injury.PLoS One. 2018 Mar 12;13(3):e0192963. doi: 10.1371/journal.pone.0192963. eCollection 2018.
353 The KCa3.1 blocker TRAM-34 inhibits proliferation of fibroblasts in paraquat-induced pulmonary fibrosis.Toxicol Lett. 2018 Oct 1;295:408-415. doi: 10.1016/j.toxlet.2018.07.020. Epub 2018 Jul 20.
354 Expression of TRB3 promotes epithelialmesenchymal transition of MLE?2 murine alveolar type II epithelial cells through the TGF?/Smad3 signaling pathway.Mol Med Rep. 2019 Apr;19(4):2869-2875. doi: 10.3892/mmr.2019.9900. Epub 2019 Jan 28.
355 Positional cloning reveals strain-dependent expression of Trim16 to alter susceptibility to bleomycin-induced pulmonary fibrosis in mice.PLoS Genet. 2013;9(1):e1003203. doi: 10.1371/journal.pgen.1003203. Epub 2013 Jan 17.
356 Loss-of-function mutations in the RNA biogenesis factor NAF1 predispose to pulmonary fibrosis-emphysema. Sci Transl Med. 2016 Aug 10;8(351):351ra107. doi: 10.1126/scitranslmed.aaf7837.