Details of the Drug Combination

General Information of Drug Combination (ID: DCYN0TA)

Drug Combination Name
Gefitinib Fulvestrant
Indication
Disease Entry Status REF
Adenocarcinoma Investigative [1]
Component Drugs Gefitinib   DM15F0X Fulvestrant   DM0YZC6
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL
High-throughput Screening Result Testing Cell Line: A549
Zero Interaction Potency (ZIP) Score: 1.13
Bliss Independence Score: 2.44
Loewe Additivity Score: 2.34
LHighest Single Agent (HSA) Score: 4.54

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Gefitinib
Disease Entry ICD 11 Status REF
Colon adenocarcinoma N.A. Approved [2]
Glioblastoma 2A00 Approved [2]
Lung cancer 2C25.0 Approved [2]
Non-small-cell lung cancer 2C25.Y Approved [2]
Rectal adenocarcinoma 2B92 Approved [2]
Rectum mucinous adenocarcinoma N.A. Approved [2]
Solid tumour/cancer 2A00-2F9Z Approved [3]
Head and neck cancer 2D42 Phase 3 [3]
Urethral cancer 2C93 Phase 2 [3]
Colon cancer 2B90.Z Investigative [2]
Colon mucinous adenocarcinoma N.A. Investigative [2]
Gefitinib Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Epidermal growth factor receptor (EGFR) TTGKNB4 EGFR_HUMAN Inhibitor [10]
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Gefitinib Interacts with 4 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [11]
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [12]
Organic anion transporting polypeptide 1B1 (SLCO1B1) DT3D8F0 SO1B1_HUMAN Substrate [13]
Organic anion transporting polypeptide 1B3 (SLCO1B3) DT9C1TS SO1B3_HUMAN Substrate [13]
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Gefitinib Interacts with 3 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [14]
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Metabolism [15]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Metabolism [14]
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Gefitinib Interacts with 103 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2) OTW8V2V1 ABCG2_HUMAN Increases ADR [16]
Epidermal growth factor receptor (EGFR) OTAPLO1S EGFR_HUMAN Decreases Response To Substance [17]
Sulfhydryl oxidase 1 (QSOX1) OT4ZPK4P QSOX1_HUMAN Increases Expression [18]
Growth arrest and DNA damage-inducible protein GADD45 gamma (GADD45G) OT8V1J4M GA45G_HUMAN Decreases Expression [18]
Interferon alpha-inducible protein 6 (IFI6) OTWOOAM4 IFI6_HUMAN Decreases Expression [18]
Fibroblast growth factor 6 (FGF6) OTRJ679P FGF6_HUMAN Increases Expression [18]
Ski oncogene (SKI) OT4KJ8F6 SKI_HUMAN Increases Expression [18]
Erythropoietin receptor (EPOR) OTUIOEU3 EPOR_HUMAN Increases Expression [18]
Nuclear factor NF-kappa-B p105 subunit (NFKB1) OTNRRD8I NFKB1_HUMAN Decreases Expression [18]
Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B) OTDS2EAR TNR1B_HUMAN Decreases Expression [18]
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A) OTDRV63V GA45A_HUMAN Increases Expression [18]
Cytochrome P450 2F1 (CYP2F1) OTY3HJH1 CP2F1_HUMAN Decreases Expression [18]
Replication protein A 70 kDa DNA-binding subunit (RPA1) OT76POLP RFA1_HUMAN Increases Expression [18]
Adenosine receptor A1 (ADORA1) OTI7X39E AA1R_HUMAN Decreases Expression [18]
14-3-3 protein sigma (SFN) OTLJCZ1U 1433S_HUMAN Decreases Expression [18]
DNA mismatch repair protein Mlh1 (MLH1) OTG5XDD8 MLH1_HUMAN Decreases Expression [18]
Glycine--tRNA ligase (GARS1) OT5B6R9Y GARS_HUMAN Increases Expression [18]
Epidermal growth factor receptor substrate 15 (EPS15) OT7NPP8U EPS15_HUMAN Increases Expression [18]
Neuronal pentraxin-2 (NPTX2) OT3SSJDP NPTX2_HUMAN Decreases Expression [18]
Leptin receptor (LEPR) OT9H7G0C LEPR_HUMAN Decreases Expression [18]
Neural retina-specific leucine zipper protein (NRL) OT65MFKQ NRL_HUMAN Decreases Expression [18]
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (GNB2) OT3JPRCQ GBB2_HUMAN Decreases Expression [18]
Retinal guanylyl cyclase 1 (GUCY2D) OT81UJI0 GUC2D_HUMAN Decreases Expression [18]
Cell growth regulator with RING finger domain protein 1 (CGRRF1) OTLMNRCL CGRF1_HUMAN Increases Expression [18]
Dual specificity protein phosphatase 9 (DUSP9) OTZZWEQL DUS9_HUMAN Decreases Expression [18]
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Decreases Activity [19]
Retinoblastoma-associated protein (RB1) OTQJUJMZ RB_HUMAN Decreases Expression [20]
Glycogen synthase kinase-3 beta (GSK3B) OTL3L14B GSK3B_HUMAN Decreases Expression [20]
Cyclin-dependent kinase 6 (CDK6) OTR95N0X CDK6_HUMAN Decreases Expression [20]
Telomerase reverse transcriptase (TERT) OT085VVA TERT_HUMAN Decreases Expression [21]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Decreases Expression [22]
Ubiquitin-like modifier-activating enzyme ATG7 (ATG7) OTVT4YA1 ATG7_HUMAN Increases Expression [23]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Decreases Expression [24]
Tumor necrosis factor (TNF) OT4IE164 TNFA_HUMAN Decreases Expression [6]
Interleukin-1 beta (IL1B) OT0DWXXB IL1B_HUMAN Increases Expression [25]
HLA class II histocompatibility antigen, DRB1 beta chain (HLA-DRB1) OTRGGIFP DRB1_HUMAN Affects Expression [26]
Estrogen receptor (ESR1) OTKLU61J ESR1_HUMAN Decreases Phosphorylation [27]
Receptor tyrosine-protein kinase erbB-2 (ERBB2) OTOAUNCK ERBB2_HUMAN Decreases Phosphorylation [28]
HLA class II histocompatibility antigen, DO alpha chain (HLA-DOA) OTZE5Q7R DOA_HUMAN Affects Expression [26]
Heat shock protein HSP 90-alpha (HSP90AA1) OTLG1WPK HS90A_HUMAN Increases Secretion [25]
Insulin-like growth factor 1 receptor (IGF1R) OTXJIF13 IGF1R_HUMAN Increases Phosphorylation [29]
High mobility group protein B1 (HMGB1) OT4B7CPF HMGB1_HUMAN Increases Secretion [25]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Increases Cleavage [30]
Heat shock 70 kDa protein 1A (HSPA1A) OTKGIE76 HS71A_HUMAN Increases Secretion [25]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Increases Secretion [31]
Matrix metalloproteinase-9 (MMP9) OTB2QDAV MMP9_HUMAN Decreases Expression [6]
Platelet endothelial cell adhesion molecule (PECAM1) OTXOM4D9 PECA1_HUMAN Decreases Expression [6]
Ribosomal protein S6 kinase beta-1 (RPS6KB1) OTAELNGX KS6B1_HUMAN Decreases Phosphorylation [23]
Alanine aminotransferase 1 (GPT) OTOXOA0Q ALAT1_HUMAN Increases Secretion [32]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Decreases Expression [17]
DnaJ homolog subfamily B member 1 (DNAJB1) OTCOSEVH DNJB1_HUMAN Increases Secretion [25]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Decreases Expression [33]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Decreases Expression [33]
Caspase-1 (CASP1) OTZ3YQFU CASP1_HUMAN Increases Activity [25]
G1/S-specific cyclin-D3 (CCND3) OTNKPQ22 CCND3_HUMAN Decreases Expression [17]
HLA class I histocompatibility antigen, alpha chain F (HLA-F) OT76CM19 HLAF_HUMAN Affects Expression [26]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Decreases Phosphorylation [34]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Decreases Expression [22]
Serine/threonine-protein kinase mTOR (MTOR) OTHH8KU7 MTOR_HUMAN Decreases Phosphorylation [23]
Cyclin-dependent kinase 4 inhibitor B (CDKN2B) OTAG24N1 CDN2B_HUMAN Increases Expression [24]
Mitogen-activated protein kinase 8 (MAPK8) OTEREYS5 MK08_HUMAN Decreases Phosphorylation [6]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Increases Expression [17]
Tumor necrosis factor ligand superfamily member 6 (FASLG) OTZARCHH TNFL6_HUMAN Increases Response To Substance [35]
Cytochrome c (CYCS) OTBFALJD CYC_HUMAN Affects Localization [30]
Transcription factor E2F1 (E2F1) OTLKYBBC E2F1_HUMAN Decreases Expression [21]
Caveolin-1 (CAV1) OTEZUR1L CAV1_HUMAN Increases Expression [33]
Sequestosome-1 (SQSTM1) OTGY5D5J SQSTM_HUMAN Decreases Expression [36]
Kelch-like ECH-associated protein 1 (KEAP1) OTFHOD0C KEAP1_HUMAN Increases Expression [37]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Increases Cleavage [35]
Cytochrome P450 1B1 (CYP1B1) OTYXFLSD CP1B1_HUMAN Decreases Activity [38]
MHC class I polypeptide-related sequence B (MICB) OTS2DVDW MICB_HUMAN Increases Expression [39]
MHC class I polypeptide-related sequence A (MICA) OTPEIEAR MICA_HUMAN Increases Expression [39]
Estrogen receptor beta (ESR2) OTXNR2WQ ESR2_HUMAN Increases Expression [40]
Serine protease HTRA1 (HTRA1) OTR8ACBF HTRA1_HUMAN Increases Expression [41]
Major histocompatibility complex class I-related gene protein (MR1) OTZU3XX7 HMR1_HUMAN Affects Expression [26]
Autophagy protein 5 (ATG5) OT4T5SMS ATG5_HUMAN Increases Expression [23]
Transcription factor SOX-17 (SOX17) OT9H4WWE SOX17_HUMAN Decreases Localization [42]
MARVEL domain-containing protein 1 (MARVELD1) OT5CPOJE MALD1_HUMAN Decreases Response To Substance [43]
GTPase KRas (KRAS) OT78QCN8 RASK_HUMAN Decreases Response To Substance [44]
Zinc finger protein SNAI2 (SNAI2) OT7Y8EJ2 SNAI2_HUMAN Affects Response To Substance [45]
Membrane-associated progesterone receptor component 1 (PGRMC1) OTBE6WAC PGRC1_HUMAN Decreases Response To Substance [46]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Increases Response To Substance [47]
Glutamate--cysteine ligase catalytic subunit (GCLC) OTESDI4D GSH1_HUMAN Affects Response To Substance [48]
RNA-binding protein 7 (RBM7) OTFIWTMF RBM7_HUMAN Affects Response To Substance [48]
Cell death regulator Aven (AVEN) OTGIN5YK AVEN_HUMAN Affects Response To Substance [48]
Forkhead box protein O3 (FOXO3) OTHXQG4P FOXO3_HUMAN Increases Response To Substance [49]
Phospholipase B-like 1 (PLBD1) OTHYEB4W PLBL1_HUMAN Affects Response To Substance [48]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Affects Response To Substance [50]
Securin (PTTG1) OTIMYS4W PTTG1_HUMAN Decreases Response To Substance [30]
Amphiregulin (AREG) OTJFOR67 AREG_HUMAN Decreases Response To Substance [48]
Pleckstrin homology-like domain family A member 2 (PHLDA2) OTMV9DPP PHLA2_HUMAN Affects Response To Substance [48]
Aurora kinase A (AURKA) OTMX0HYT AURKA_HUMAN Decreases Response To Substance [50]
DNA excision repair protein ERCC-1 (ERCC1) OTNPYQHI ERCC1_HUMAN Affects Response To Substance [9]
Bcl-2-like protein 11 (BCL2L11) OTNQQWFJ B2L11_HUMAN Increases Response To Substance [51]
Ceramide transfer protein (CERT1) OTNUCNHX CERT_HUMAN Affects Response To Substance [48]
DNA repair protein RAD51 homolog 1 (RAD51) OTNVWGC1 RAD51_HUMAN Affects Response To Substance [52]
Oncostatin-M-specific receptor subunit beta (OSMR) OTORWHPL OSMR_HUMAN Affects Response To Substance [48]
Protransforming growth factor alpha (TGFA) OTPD1LL9 TGFA_HUMAN Decreases Response To Substance [53]
Dual specificity protein phosphatase 3 (DUSP3) OTPJX9B4 DUS3_HUMAN Affects Response To Substance [48]
Transcription factor p65 (RELA) OTUJP9CN TF65_HUMAN Decreases Response To Substance [50]
Pericentrin (PCNT) OTW4Z65J PCNT_HUMAN Decreases Response To Substance [46]
Coronin-1C (CORO1C) OTXDF9T3 COR1C_HUMAN Affects Response To Substance [48]
Ribonucleoside-diphosphate reductase large subunit (RRM1) OTXGQOR9 RIR1_HUMAN Affects Response To Substance [9]
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⏷ Show the Full List of 103 DOT(s)
Indication(s) of Fulvestrant
Disease Entry ICD 11 Status REF
Breast cancer 2C60-2C65 Approved [4]
Fulvestrant Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Estrogen receptor (ESR) TTZAYWL ESR1_HUMAN Antagonist [62]
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Fulvestrant Interacts with 2 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [63]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DEYGVN4 UD11_HUMAN Metabolism [64]
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Fulvestrant Interacts with 985 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Superoxide dismutase (SOD1) OT39TA1L SODC_HUMAN Increases Expression [55]
Transferrin receptor protein 1 (TFRC) OT8ZPBDL TFR1_HUMAN Increases Expression [55]
Transcription factor Jun (JUN) OTCYBO6X JUN_HUMAN Increases Expression [55]
Integrin beta-1 (ITGB1) OT6G1IAR ITB1_HUMAN Increases Expression [55]
Macrophage colony-stimulating factor 1 (CSF1) OT68M7RD CSF1_HUMAN Increases Expression [55]
DNA topoisomerase 2-alpha (TOP2A) OT6LPS08 TOP2A_HUMAN Increases Expression [55]
C-C motif chemokine 5 (CCL5) OTSCA5CK CCL5_HUMAN Increases Expression [55]
G2/mitotic-specific cyclin-B1 (CCNB1) OT19S7E5 CCNB1_HUMAN Increases Expression [55]
Ephrin type-A receptor 1 (EPHA1) OTGJMRZ0 EPHA1_HUMAN Increases Expression [55]
Proteinase-activated receptor 1 (F2R) OT4WVWBO PAR1_HUMAN Increases Expression [55]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Increases Expression [55]
Caspase-4 (CASP4) OTVQTV1L CASP4_HUMAN Increases Expression [55]
Dual specificity protein kinase CLK1 (CLK1) OTG1LACW CLK1_HUMAN Increases Expression [55]
Ras-related protein Rab-2A (RAB2A) OT6SK83U RAB2A_HUMAN Increases Expression [55]
CCHC-type zinc finger nucleic acid binding protein (CNBP) OTTGM9NK CNBP_HUMAN Increases Expression [55]
Dynein light chain 1, cytoplasmic (DYNLL1) OTR69LHT DYL1_HUMAN Increases Expression [55]
Paired box protein Pax-5 (PAX5) OTYBJJWX PAX5_HUMAN Increases Expression [55]
GA-binding protein alpha chain (GABPA) OT9YB2SA GABPA_HUMAN Increases Expression [55]
Mitogen-activated protein kinase kinase kinase 11 (MAP3K11) OT0EYZAY M3K11_HUMAN Increases Expression [55]
ATP-binding cassette sub-family C member 3 (ABCC3) OTC3IJV4 MRP3_HUMAN Increases Expression [54]
ATP-binding cassette sub-family C member 5 (ABCC5) OT34G4US MRP5_HUMAN Decreases Expression [54]
Transforming acidic coiled-coil-containing protein 1 (TACC1) OTGX20TE TACC1_HUMAN Increases Expression [54]
Cystatin-A (CSTA) OT1K68KE CYTA_HUMAN Decreases Expression [54]
Protein c-Fos (FOS) OTJBUVWS FOS_HUMAN Decreases Expression [54]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Decreases Expression [54]
Receptor tyrosine-protein kinase erbB-2 (ERBB2) OTOAUNCK ERBB2_HUMAN Increases Expression [54]
Proliferating cell nuclear antigen (PCNA) OTHZ1RIA PCNA_HUMAN Decreases Expression [54]
Cyclin-A2 (CCNA2) OTPHHYZJ CCNA2_HUMAN Decreases Expression [54]
Ephrin-A1 (EFNA1) OTU2NUA2 EFNA1_HUMAN Increases Expression [54]
Insulin-like growth factor-binding protein 4 (IGFBP4) OT2HZRBD IBP4_HUMAN Decreases Expression [54]
Insulin receptor substrate 1 (IRS1) OTNO82CU IRS1_HUMAN Decreases Expression [54]
CCN family member 3 (CCN3) OTOW5YL4 CCN3_HUMAN Increases Expression [54]
Matrix metalloproteinase-15 (MMP15) OT1XF517 MMP15_HUMAN Increases Expression [54]
Neprilysin (MME) OT5Q39P8 NEP_HUMAN Increases Expression [65]
Interferon alpha-inducible protein 6 (IFI6) OTWOOAM4 IFI6_HUMAN Increases Expression [65]
Amphiregulin (AREG) OTJFOR67 AREG_HUMAN Decreases Expression [65]
Trefoil factor 3 (TFF3) OTJJDRTU TFF3_HUMAN Decreases Expression [65]
Interferon-related developmental regulator 1 (IFRD1) OT4SQMLQ IFRD1_HUMAN Decreases Expression [56]
26S proteasome non-ATPase regulatory subunit 14 (PSMD14) OTJWHMZ5 PSDE_HUMAN Decreases Expression [56]
Aurora kinase A (AURKA) OTMX0HYT AURKA_HUMAN Decreases Expression [56]
Protein phosphatase 1D (PPM1D) OT8NLZ9D PPM1D_HUMAN Decreases Expression [56]
ATP-dependent RNA helicase DDX3Y (DDX3Y) OTKL1FNX DDX3Y_HUMAN Decreases Expression [56]
Asparagine--tRNA ligase, cytoplasmic (NARS1) OTFS4J1W SYNC_HUMAN Decreases Expression [56]
Trafficking kinesin-binding protein 2 (TRAK2) OTXVA7FN TRAK2_HUMAN Decreases Expression [56]
Calsyntenin-1 (CLSTN1) OTQN35G2 CSTN1_HUMAN Decreases Expression [56]
Kinesin-like protein KIF20A (KIF20A) OTXOQHE0 KI20A_HUMAN Decreases Expression [56]
Apolipoprotein D (APOD) OTT77XW8 APOD_HUMAN Increases Expression [56]
Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1) OTM0GDTP IF2A_HUMAN Decreases Expression [56]
Nucleophosmin (NPM1) OTTBYYT0 NPM_HUMAN Decreases Expression [56]
Heat shock protein HSP 90-beta (HSP90AB1) OTR69EG7 HS90B_HUMAN Decreases Expression [56]
Asparagine synthetase (ASNS) OT8R922G ASNS_HUMAN Decreases Expression [56]
Matrix Gla protein (MGP) OTZWU3FU MGP_HUMAN Decreases Expression [56]
High mobility group protein B1 (HMGB1) OT4B7CPF HMGB1_HUMAN Decreases Expression [56]
Pro-cathepsin H (CTSH) OTLFL0DG CATH_HUMAN Increases Expression [56]
60 kDa heat shock protein, mitochondrial (HSPD1) OTTO1Y11 CH60_HUMAN Decreases Expression [56]
Heat shock cognate 71 kDa protein (HSPA8) OTJI2RCI HSP7C_HUMAN Decreases Expression [56]
DNA topoisomerase 1 (TOP1) OT51O0CF TOP1_HUMAN Decreases Expression [56]
Endoplasmin (HSP90B1) OT02XLBR ENPL_HUMAN Decreases Expression [56]
Stathmin (STMN1) OTDJ4RV0 STMN1_HUMAN Decreases Expression [56]
Protein SON (SON) OT9VWV18 SON_HUMAN Decreases Expression [56]
Nucleolin (NCL) OTBXPKMP NUCL_HUMAN Decreases Expression [56]
Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1) OTBZKX4P ROA2_HUMAN Decreases Expression [56]
Nuclear receptor subfamily 4immunitygroup A member 1 (NR4A1) OTGP6GA4 NR4A1_HUMAN Increases Expression [56]
Splicing factor, proline- and glutamine-rich (SFPQ) OTLCIAPJ SFPQ_HUMAN Decreases Expression [56]
Ribonucleoside-diphosphate reductase large subunit (RRM1) OTXGQOR9 RIR1_HUMAN Decreases Expression [56]
Signal transducer CD24 (CD24) OT7CODJ4 CD24_HUMAN Increases Expression [56]
Threonine--tRNA ligase 1, cytoplasmic (TARS1) OT0PWST5 SYTC_HUMAN Decreases Expression [56]
DNA-directed RNA polymerase II subunit RPB2 (POLR2B) OTS3F0H2 RPB2_HUMAN Decreases Expression [56]
Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) OTFRWOLM HNRH1_HUMAN Decreases Expression [56]
Heat shock 70 kDa protein 4 (HSPA4) OT5HR0AR HSP74_HUMAN Decreases Expression [56]
Thrombospondin-2 (THBS2) OTXET551 TSP2_HUMAN Decreases Expression [56]
Coatomer subunit beta' (COPB2) OT82JIGC COPB2_HUMAN Decreases Expression [56]
Lamina-associated polypeptide 2, isoform alpha (TMPO) OTL68EL4 LAP2A_HUMAN Decreases Expression [56]
Signal transducer and activator of transcription 1-alpha/beta (STAT1) OTLMBUZ6 STAT1_HUMAN Decreases Expression [56]
Matrin-3 (MATR3) OTESJ5S7 MATR3_HUMAN Decreases Expression [56]
Ras GTPase-activating-like protein IQGAP1 (IQGAP1) OTZRWTGA IQGA1_HUMAN Decreases Expression [56]
Histone H3-like centromeric protein A (CENPA) OT0NEJ4X CENPA_HUMAN Decreases Expression [56]
Sulfate transporter (SLC26A2) OTJNHNTO S26A2_HUMAN Decreases Expression [56]
Importin subunit alpha-1 (KPNA2) OTU7FOE6 IMA1_HUMAN Decreases Expression [56]
Eukaryotic translation initiation factor 5 (EIF5) OT79PQUN IF5_HUMAN Decreases Expression [56]
Ras-related protein Rap-1A (RAP1A) OT5RH6TI RAP1A_HUMAN Decreases Expression [56]
DNA-dependent protein kinase catalytic subunit (PRKDC) OTJVS4EG PRKDC_HUMAN Decreases Expression [56]
Chromobox protein homolog 1 (CBX1) OT2L4XZX CBX1_HUMAN Decreases Expression [56]
Heterogeneous nuclear ribonucleoprotein U (HNRNPU) OTLQN1E2 HNRPU_HUMAN Decreases Expression [56]
Large ribosomal subunit protein eL6 (RPL6) OTRU71O4 RL6_HUMAN Decreases Expression [56]
DNA topoisomerase 2-beta (TOP2B) OTDHKQZ8 TOP2B_HUMAN Decreases Expression [56]
Serine/arginine-rich splicing factor 1 (SRSF1) OTF61HOV SRSF1_HUMAN Decreases Expression [56]
ATP-dependent RNA helicase A (DHX9) OT5AAOQI DHX9_HUMAN Decreases Expression [56]
Neuroblast differentiation-associated protein AHNAK (AHNAK) OT6KH1WG AHNK_HUMAN Decreases Expression [56]
Zinc transporter ZIP6 (SLC39A6) OTCYF466 S39A6_HUMAN Decreases Expression [56]
Importin subunit beta-1 (KPNB1) OTBT2HFL IMB1_HUMAN Decreases Expression [56]
Proteasome activator complex subunit 4 (PSME4) OTDGF53O PSME4_HUMAN Decreases Expression [56]
Condensin complex subunit 2 (NCAPH) OTXOS97C CND2_HUMAN Decreases Expression [56]
PCNA-associated factor (PCLAF) OTMVIOUU PAF15_HUMAN Decreases Expression [56]
26S proteasome non-ATPase regulatory subunit 6 (PSMD6) OTX59EGK PSMD6_HUMAN Decreases Expression [56]
Elongin-B (ELOB) OTZ3X84T ELOB_HUMAN Decreases Expression [56]
Histone-binding protein RBBP7 (RBBP7) OTLB56HX RBBP7_HUMAN Decreases Expression [56]
Transcription initiation factor TFIID subunit 9 (TAF9) OTCTH3C6 TAF9_HUMAN Decreases Expression [56]
Golgin subfamily A member 5 (GOLGA5) OTG6HB6U GOGA5_HUMAN Decreases Expression [56]
Transportin-1 (TNPO1) OT7W2CM8 TNPO1_HUMAN Decreases Expression [56]
Dehydrodolichyl diphosphate synthase complex subunit NUS1 (NUS1) OT4DQ82L NGBR_HUMAN Decreases Expression [56]
UAP56-interacting factor (FYTTD1) OTXXKQJR UIF_HUMAN Decreases Expression [56]
Rac GTPase-activating protein 1 (RACGAP1) OTQE8IEH RGAP1_HUMAN Decreases Expression [56]
Protein ILRUN (ILRUN) OTE8FHQD ILRUN_HUMAN Decreases Expression [56]
Aryl hydrocarbon receptor nuclear translocator 2 (ARNT2) OTAQD3YV ARNT2_HUMAN Increases Expression [56]
Nucleolar RNA helicase 2 (DDX21) OTV73GMZ DDX21_HUMAN Decreases Expression [56]
Very long chain fatty acid elongase 5 (ELOVL5) OT375W1Z ELOV5_HUMAN Decreases Expression [56]
Serine/threonine-protein kinase 26 (STK26) OTW4QE0D STK26_HUMAN Decreases Expression [56]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Increases Expression [66]
Serine/threonine-protein kinase Sgk1 (SGK1) OT301T1U SGK1_HUMAN Decreases Expression [57]
Prostaglandin E synthase (PTGES) OTB7YQFU PTGES_HUMAN Decreases Expression [57]
E3 ubiquitin-protein ligase SIAH2 (SIAH2) OTKED2XN SIAH2_HUMAN Decreases Expression [57]
Carbonic anhydrase 12 (CA12) OT6WNFU8 CAH12_HUMAN Decreases Expression [57]
Tyrosine-protein kinase JAK2 (JAK2) OTBIDOOR JAK2_HUMAN Decreases Expression [57]
monooxygenase MICAL2 (MICAL2) OT04OQQJ MICA2_HUMAN Decreases Expression [57]
Transcription factor AP-2-alpha (TFAP2A) OTMYT3NK AP2A_HUMAN Increases Expression [57]
Proto-oncogene tyrosine-protein kinase receptor Ret (RET) OTLU040A RET_HUMAN Decreases Expression [57]
Monoacylglycerol lipase ABHD2 (ABHD2) OTCRUOCS ABHD2_HUMAN Decreases Expression [57]
Transcriptional activator Myb (MYB) OTJH64IV MYB_HUMAN Decreases Expression [57]
Myb-related protein A (MYBL1) OTBJMC2P MYBA_HUMAN Decreases Expression [57]
Tissue factor pathway inhibitor (TFPI) OTA0FX16 TFPI1_HUMAN Increases Expression [57]
Delta-aminolevulinic acid dehydratase (ALAD) OTHM9GSH HEM2_HUMAN Increases Expression [57]
CD44 antigen (CD44) OT9TTJ41 CD44_HUMAN Decreases Expression [57]
Stromal cell-derived factor 1 (CXCL12) OT2QX5LL SDF1_HUMAN Decreases Expression [57]
Ephrin type-A receptor 4 (EPHA4) OT3AMK0C EPHA4_HUMAN Increases Expression [57]
Single-stranded DNA-binding protein 2 (SSBP2) OTYG1G80 SSBP2_HUMAN Increases Expression [57]
Large neutral amino acids transporter small subunit 1 (SLC7A5) OT2WPVXD LAT1_HUMAN Decreases Expression [57]
DNA-binding protein inhibitor ID-3 (ID3) OTUULW5Z ID3_HUMAN Increases Expression [57]
Urokinase plasminogen activator surface receptor (PLAUR) OTIRKKEQ UPAR_HUMAN Decreases Expression [57]
Early growth response protein 3 (EGR3) OTGPJIRA EGR3_HUMAN Decreases Expression [57]
Forkhead box protein C1 (FOXC1) OTOWZGYO FOXC1_HUMAN Decreases Expression [57]
Cyclin-G2 (CCNG2) OTII38K2 CCNG2_HUMAN Increases Expression [57]
Kynureninase (KYNU) OTINL2RE KYNU_HUMAN Increases Expression [57]
Na(+)/H(+) exchange regulatory cofactor NHE-RF3 (PDZK1) OTGFK4MH NHRF3_HUMAN Decreases Expression [57]
Phosphatidylinositol 3-kinase regulatory subunit gamma (PIK3R3) OTXGJ8N1 P55G_HUMAN Increases Expression [57]
Dual specificity tyrosine-phosphorylation-regulated kinase 2 (DYRK2) OTMDVWPS DYRK2_HUMAN Increases Expression [57]
Transcription factor AP-2 gamma (TFAP2C) OTUDIW05 AP2C_HUMAN Decreases Expression [57]
Serine/threonine-protein kinase Sgk3 (SGK3) OTQ6QO99 SGK3_HUMAN Decreases Expression [57]
Inactive rhomboid protein 1 (RHBDF1) OTCQ7UDS RHDF1_HUMAN Increases Expression [57]
Calmin (CLMN) OT7U5J3T CLMN_HUMAN Increases Expression [57]
DNA endonuclease RBBP8 (RBBP8) OTRHJ3GI CTIP_HUMAN Decreases Expression [57]
Noelin (OLFM1) OTOYPEWW NOE1_HUMAN Decreases Expression [57]
Pleckstrin homology domain-containing family F member 2 (PLEKHF2) OTBGDG8C PKHF2_HUMAN Increases Expression [57]
Spermine oxidase (SMOX) OT11E62Y SMOX_HUMAN Decreases Expression [57]
Nicotinamide riboside kinase 1 (NMRK1) OT0STQLV NRK1_HUMAN Decreases Expression [57]
Rap guanine nucleotide exchange factor-like 1 (RAPGEFL1) OTYKE9ZM RPGFL_HUMAN Decreases Expression [57]
RNA 3'-terminal phosphate cyclase-like protein (RCL1) OT7O00YX RCL1_HUMAN Decreases Expression [57]
Cytochrome P450 1B1 (CYP1B1) OTYXFLSD CP1B1_HUMAN Increases Expression [67]
Extended synaptotagmin-3 (ESYT3) OTG5H3YF ESYT3_HUMAN Increases Methylation [58]
FERM domain-containing protein 3 (FRMD3) OT0CD2GG FRMD3_HUMAN Increases Methylation [58]
Dystrotelin (DYTN) OTC5QZ6R DYTN_HUMAN Increases Methylation [58]
Coiled-coil domain-containing protein 144A (CCDC144A) OTN9UZHR C144A_HUMAN Decreases Methylation [58]
Transmembrane protein 89 (TMEM89) OTZLX09R TMM89_HUMAN Increases Methylation [58]
Delphilin (GRID2IP) OTNDNC0W GRD2I_HUMAN Increases Methylation [58]
Paralemmin-3 (PALM3) OTB83R61 PALM3_HUMAN Increases Methylation [58]
Rho GTPase-activating protein 42 (ARHGAP42) OTIDSJMK RHG42_HUMAN Increases Methylation [58]
Ciliary microtubule inner protein 2C (CIMIP2C) OTKXQKQ4 CMI2C_HUMAN Increases Methylation [58]
Fidgetin-like protein 2 (FIGNL2) OT0GD7S6 FIGL2_HUMAN Increases Methylation [58]
Dorsal root ganglia homeobox protein (DRGX) OTDLEGNE DRGX_HUMAN Increases Methylation [58]
Uncharacterized protein C12orf71 (C12ORF71) OTUFA24U CL071_HUMAN Increases Methylation [58]
Uncharacterized protein C16orf90 (C16ORF90) OTAYN87M CP090_HUMAN Increases Methylation [58]
Isthmin-1 (ISM1) OTZTK2TV ISM1_HUMAN Increases Methylation [58]
Rab GTPase-activating protein 1-like, isoform 10 (RABGAP1L) OT7QO47I RBG10_HUMAN Increases Methylation [58]
Uncharacterized protein C19orf84 (C19ORF84) OT4MVCU6 CS084_HUMAN Increases Methylation [58]
Golgi-associated olfactory signaling regulator (GFY) OTM64CSN GFY_HUMAN Increases Methylation [58]
ATP-dependent RNA helicase DDX39A (DDX39A) OT0Z6E1K DX39A_HUMAN Increases Methylation [58]
Cytosolic acyl coenzyme A thioester hydrolase (ACOT7) OT7C68YV BACH_HUMAN Increases Methylation [58]
Synaptosomal-associated protein 23 (SNAP23) OTY2MYBX SNP23_HUMAN Increases Methylation [58]
Splicing regulator ARVCF (ARVCF) OT78DKOU ARVC_HUMAN Increases Methylation [58]
AP-3 complex subunit beta-1 (AP3B1) OTYTIH5Q AP3B1_HUMAN Decreases Expression [60]
E3 ubiquitin-protein ligase RNF103 (RNF103) OT9DOB4H RN103_HUMAN Increases Methylation [58]
Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) OTQ4W7MT TR11B_HUMAN Increases Expression [60]
Importin-5 (IPO5) OTAK40ED IPO5_HUMAN Increases Methylation [58]
Histone deacetylase complex subunit SAP18 (SAP18) OTJAZWOL SAP18_HUMAN Increases Methylation [58]
Nuclear receptor subfamily 5 group A member 2 (NR5A2) OTXAUJAS NR5A2_HUMAN Increases Expression [60]
Serine/threonine-protein kinase 25 (STK25) OT4YPNTF STK25_HUMAN Increases Methylation [58]
Receptor-binding cancer antigen expressed on SiSo cells (EBAG9) OTTQLQCP RCAS1_HUMAN Decreases Expression [60]
Pro-neuregulin-2, membrane-bound isoform (NRG2) OTMDE844 NRG2_HUMAN Increases Methylation [58]
Homeobox protein cut-like 2 (CUX2) OTDJTQAJ CUX2_HUMAN Increases Methylation [58]
Suppressor of cytokine signaling 3 (SOCS3) OTY183WJ SOCS3_HUMAN Decreases Expression [60]
Olfactory receptor 7A17 (OR7A17) OTFYB5NE OR7AH_HUMAN Increases Methylation [58]
Telomerase reverse transcriptase (TERT) OT085VVA TERT_HUMAN Decreases Expression [68]
Guanine nucleotide-binding protein subunit beta-5 (GNB5) OT3ZSAXH GNB5_HUMAN Increases Methylation [58]
Kinetochore protein NDC80 homolog (NDC80) OTS7D306 NDC80_HUMAN Decreases Expression [59]
Neuropilin-1 (NRP1) OTCGULYV NRP1_HUMAN Decreases Expression [60]
Ras-specific guanine nucleotide-releasing factor 2 (RASGRF2) OT67DAGF RGRF2_HUMAN Decreases Methylation [58]
Protocadherin-17 (PCDH17) OTRK0M05 PCD17_HUMAN Decreases Methylation [58]
Regulator of G-protein signaling 12 (RGS12) OTNCIQTH RGS12_HUMAN Increases Methylation [58]
Microtubule-associated serine/threonine-protein kinase 4 (MAST4) OT3LOE2J MAST4_HUMAN Increases Methylation [58]
Guanine nucleotide exchange factor DBS (MCF2L) OTEURA8N MCF2L_HUMAN Affects Methylation [58]
Ephrin type-B receptor 6 (EPHB6) OTKNN6GC EPHB6_HUMAN Increases Methylation [58]
Laminin subunit alpha-5 (LAMA5) OTIIXE4M LAMA5_HUMAN Increases Methylation [58]
Ataxin-7 (ATXN7) OTL3YF1H ATX7_HUMAN Decreases Methylation [58]
Tumor protein p73 (TP73) OT0LUO47 P73_HUMAN Increases Methylation [58]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Decreases Expression [59]
Trinucleotide repeat-containing gene 18 protein (TNRC18) OTREUWWG TNC18_HUMAN Decreases Methylation [58]
Tapasin (TAPBP) OTL81AVZ TPSN_HUMAN Increases Methylation [58]
Rho guanine nucleotide exchange factor 9 (ARHGEF9) OTB1FLIW ARHG9_HUMAN Increases Methylation [58]
ERI1 exoribonuclease 3 (ERI3) OT0HIU61 ERI3_HUMAN Increases Methylation [58]
Histone-lysine N-methyltransferase SUV39H1 (SUV39H1) OTDTF5BU SUV91_HUMAN Increases Methylation [58]
Forkhead box protein O3 (FOXO3) OTHXQG4P FOXO3_HUMAN Affects Localization [69]
Protein sprouty homolog 2 (SPRY2) OTH0CRCZ SPY2_HUMAN Affects Methylation [58]
Pleiotropic regulator 1 (PLRG1) OTIVZ5LL PLRG1_HUMAN Increases Methylation [58]
Protein regulator of cytokinesis 1 (PRC1) OTHD0XS0 PRC1_HUMAN Decreases Expression [60]
Mitotic checkpoint serine/threonine-protein kinase BUB1 (BUB1) OT80DZMT BUB1_HUMAN Decreases Expression [59]
Sialic acid-binding Ig-like lectin 6 (SIGLEC6) OTO4F5C9 SIGL6_HUMAN Increases Methylation [58]
Tolloid-like protein 1 (TLL1) OTK9NM7G TLL1_HUMAN Decreases Methylation [58]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (BNIP3L) OTJKOMXE BNI3L_HUMAN Increases Methylation [58]
NUAK family SNF1-like kinase 1 (NUAK1) OTLLHJJQ NUAK1_HUMAN Increases Methylation [58]
Phospholipid-transporting ATPase VA (ATP10A) OTYF5A7X AT10A_HUMAN Decreases Methylation [58]
Protein ENTREP2 (ENTREP2) OTEUHFKS EREP2_HUMAN Increases Methylation [58]
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma (PIP5K1C) OT3LPG1R PI51C_HUMAN Decreases Methylation [58]
Gasdermin-E (GSDME) OT1ZWY32 GSDME_HUMAN Increases Methylation [58]
Docking protein 2 (DOK2) OTIJ38UF DOK2_HUMAN Increases Methylation [58]
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (BUB1B) OT8KME51 BUB1B_HUMAN Decreases Expression [59]
Musculin (MSC) OTBRPZL5 MUSC_HUMAN Increases Methylation [58]
Catenin delta-1 (CTNND1) OTUMPSHR CTND1_HUMAN Decreases Methylation [58]
Low-density lipoprotein receptor-related protein 3 (LRP3) OTXMLT8C LRP3_HUMAN Increases Methylation [58]
Protein CBFA2T3 (CBFA2T3) OTOJ10S1 MTG16_HUMAN Increases Methylation [58]
Multiple epidermal growth factor-like domains protein 6 (MEGF6) OTEUYTP1 MEGF6_HUMAN Increases Methylation [58]
Rho-associated protein kinase 2 (ROCK2) OTVYN14T ROCK2_HUMAN Increases Methylation [58]
TSC22 domain family protein 2 (TSC22D2) OTFXF349 T22D2_HUMAN Increases Methylation [58]
Cadherin-16 (CDH16) OTR0GE9G CAD16_HUMAN Increases Methylation [58]
Nuclear receptor corepressor 1 (NCOR1) OT04XNOU NCOR1_HUMAN Increases Expression [60]
Alpha-tectorin (TECTA) OT5E0NE2 TECTA_HUMAN Decreases Methylation [58]
Nuclear receptor subfamily 1 group I member 2 (NR1I2) OTC5U0N5 NR1I2_HUMAN Increases Activity [70]
PC4 and SFRS1-interacting protein (PSIP1) OT4YAFUS PSIP1_HUMAN Increases Methylation [58]
Carbonic anhydrase-related protein 11 (CA11) OT8RX3AJ CAH11_HUMAN Decreases Methylation [58]
Disabled homolog 1 (DAB1) OTPL9MA3 DAB1_HUMAN Increases Methylation [58]
Serpin B7 (SERPINB7) OTZ95LR2 SPB7_HUMAN Increases Methylation [58]
Cell cycle checkpoint protein RAD17 (RAD17) OT1I93DT RAD17_HUMAN Increases Methylation [58]
CCN family member 5 (CCN5) OTADU8JJ CCN5_HUMAN Increases Expression [60]
Regulator of G-protein signaling 20 (RGS20) OT6CGYHW RGS20_HUMAN Increases Methylation [58]
Serine/threonine-protein kinase 17B (STK17B) OT4NYNO8 ST17B_HUMAN Increases Methylation [58]
Slit homolog 2 protein (SLIT2) OTLS2RJ4 SLIT2_HUMAN Increases Methylation [58]
Dendrin (DDN) OTM52ZF5 DEND_HUMAN Increases Methylation [58]
Protein FAM13A (FAM13A) OTZ6GN0Q FA13A_HUMAN Decreases Methylation [58]
G2/mitotic-specific cyclin-B2 (CCNB2) OTIEXTDK CCNB2_HUMAN Decreases Expression [59]
Serine protease 23 (PRSS23) OT6DQAM1 PRS23_HUMAN Increases Methylation [58]
NADH dehydrogenase 1 beta subcomplex subunit 2, mitochondrial (NDUFB2) OT4717TF NDUB2_HUMAN Increases Methylation [58]
Potassium voltage-gated channel subfamily H member 1 (KCNH1) OTZZXWER KCNH1_HUMAN Decreases Expression [71]
NADH dehydrogenase 1 alpha subcomplex subunit 10, mitochondrial (NDUFA10) OTBURQ3A NDUAA_HUMAN Decreases Methylation [58]
CUGBP Elav-like family member 2 (CELF2) OTLJJ4VT CELF2_HUMAN Increases Methylation [58]
Homeobox protein SIX3 (SIX3) OTP5E3VU SIX3_HUMAN Decreases Methylation [58]
Transforming acidic coiled-coil-containing protein 2 (TACC2) OTW4M7HI TACC2_HUMAN Increases Methylation [58]
Supervillin (SVIL) OTWQQ1WK SVIL_HUMAN Increases Methylation [58]
Sodium-dependent phosphate transport protein 2B (SLC34A2) OTLFMBB0 NPT2B_HUMAN Increases Methylation [58]
Adhesion G protein-coupled receptor L2 (ADGRL2) OTCXD2YR AGRL2_HUMAN Decreases Methylation [58]
Solute carrier family 2, facilitated glucose transporter member 10 (SLC2A10) OTL32QH7 GTR10_HUMAN Decreases Methylation [58]
Apoptosis-inducing factor 1, mitochondrial (AIFM1) OTKPWB7Q AIFM1_HUMAN Decreases Methylation [58]
Zinc finger protein SNAI1 (SNAI1) OTDPYAMC SNAI1_HUMAN Increases Expression [60]
Phosphatidylserine lipase ABHD16A (ABHD16A) OTDS9K1Z ABHGA_HUMAN Increases Methylation [58]
Uncharacterized protein C6orf47 (C6ORF47) OTMKBNDD CF047_HUMAN Increases Methylation [58]
One cut domain family member 2 (ONECUT2) OTHUE5YY ONEC2_HUMAN Increases Methylation [58]
Cholesterol 25-hydroxylase (CH25H) OT9S2BSW CH25H_HUMAN Increases Methylation [58]
Securin (PTTG1) OTIMYS4W PTTG1_HUMAN Decreases Expression [72]
G1/S-specific cyclin-E2 (CCNE2) OTBBUKQQ CCNE2_HUMAN Decreases Expression [59]
Aspartate aminotransferase, mitochondrial (GOT2) OT6XBWN0 AATM_HUMAN Increases Methylation [58]
Adenosine deaminase (ADA) OTOX2872 ADA_HUMAN Decreases Methylation [58]
Complement C3 (C3) OTCH5GS0 CO3_HUMAN Decreases Expression [60]
Pro-epidermal growth factor (EGF) OTANRJ0L EGF_HUMAN Affects Activity [73]
Protransforming growth factor alpha (TGFA) OTPD1LL9 TGFA_HUMAN Increases Expression [60]
Transforming growth factor beta-1 proprotein (TGFB1) OTV5XHVH TGFB1_HUMAN Increases Expression [74]
Prolactin (PRL) OTWFQGX7 PRL_HUMAN Decreases Secretion [75]
Interleukin-1 beta (IL1B) OT0DWXXB IL1B_HUMAN Increases Expression [76]
Complement component C9 (C9) OT7I5FDX CO9_HUMAN Increases Methylation [58]
Lactotransferrin (LTF) OT8JWCZ0 TRFL_HUMAN Increases Expression [60]
Estrogen receptor (ESR1) OTKLU61J ESR1_HUMAN Decreases Expression [77]
Glucocorticoid receptor (NR3C1) OTCI2YDI GCR_HUMAN Increases Expression [60]
Trefoil factor 1 (TFF1) OTCYQH4F TFF1_HUMAN Decreases Expression [78]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Decreases Expression [79]
Non-histone chromosomal protein HMG-14 (HMGN1) OTSMGH99 HMGN1_HUMAN Decreases Methylation [58]
Plasminogen activator inhibitor 2 (SERPINB2) OT72QLZB PAI2_HUMAN Increases Expression [76]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Increases Expression [76]
Keratin, type I cytoskeletal 18 (KRT18) OTVLQFIP K1C18_HUMAN Increases Methylation [58]
Tyrosine-protein kinase Lck (LCK) OT883FG9 LCK_HUMAN Increases Methylation [58]
Retinoblastoma-associated protein (RB1) OTQJUJMZ RB_HUMAN Decreases Phosphorylation [80]
Progesterone receptor (PGR) OT0FZ3QE PRGR_HUMAN Decreases Expression [81]
Cyclin-dependent kinase 1 (CDK1) OTW1SC2N CDK1_HUMAN Decreases Expression [59]
ATP synthase subunit beta, mitochondrial (ATP5F1B) OTLFZUQK ATPB_HUMAN Increases Expression [82]
Complement C2 (C2) OTHMF4YM CO2_HUMAN Increases Methylation [58]
Lipoprotein lipase (LPL) OTTW0267 LIPL_HUMAN Decreases Expression [60]
Neurofilament medium polypeptide (NEFM) OT8VCBNF NFM_HUMAN Increases Methylation [58]
Thyroid peroxidase (TPO) OTJJLL20 PERT_HUMAN Increases Methylation [58]
Prostate-specific antigen (KLK3) OTFGSBFJ KLK3_HUMAN Decreases Expression [60]
Cathepsin D (CTSD) OTQZ36F3 CATD_HUMAN Decreases Expression [78]
Heat shock protein HSP 90-alpha (HSP90AA1) OTLG1WPK HS90A_HUMAN Increases Expression [60]
Tyrosine-protein kinase Lyn (LYN) OTP686K2 LYN_HUMAN Increases Methylation [58]
Thrombospondin-1 (THBS1) OT0ECWK3 TSP1_HUMAN Increases Expression [60]
Insulin-like growth factor 1 receptor (IGF1R) OTXJIF13 IGF1R_HUMAN Increases Phosphorylation [83]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Increases Expression [84]
Insulin-like growth factor-binding protein 1 (IGFBP1) OT6UQV2K IBP1_HUMAN Increases Expression [60]
Galectin-1 (LGALS1) OT8LDFWR LEG1_HUMAN Increases Expression [60]
Heme oxygenase 1 (HMOX1) OTC1W6UX HMOX1_HUMAN Decreases Expression [76]
Granulocyte colony-stimulating factor (CSF3) OT9GC6TP CSF3_HUMAN Decreases Expression [76]
Histone H2A.Z (H2AZ1) OT3KJJNQ H2AZ_HUMAN Decreases Expression [85]
Protein RD3-like (RD3L) OTLV3BU0 RD3L_HUMAN Increases Methylation [58]
Granzyme B (GZMB) OTPPVIRS GRAB_HUMAN Decreases Expression [74]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Increases Expression [76]
Lysosomal alpha-glucosidase (GAA) OT03PU29 LYAG_HUMAN Increases Methylation [58]
Androgen receptor (AR) OTUBKAZZ ANDR_HUMAN Decreases Expression [81]
Retinoic acid receptor alpha (RARA) OT192V9V RARA_HUMAN Decreases Expression [60]
Osteopontin (SPP1) OTJGC23Y OSTP_HUMAN Increases Expression [60]
Nuclear receptor subfamily 2 group F member 6 (NR2F6) OTNVO2B6 NR2F6_HUMAN Increases Expression [60]
Transforming growth factor beta-3 proprotein (TGFB3) OT2LOUQ1 TGFB3_HUMAN Decreases Expression [60]
Microtubule-associated protein tau (MAPT) OTMTP2Z7 TAU_HUMAN Decreases Expression [86]
Mast/stem cell growth factor receptor Kit (KIT) OTHUY3VZ KIT_HUMAN Increases Methylation [58]
Ras-related protein Ral-A (RALA) OT734R7X RALA_HUMAN Increases Expression [60]
Spectrin beta chain, erythrocytic (SPTB) OT1Q9ABM SPTB1_HUMAN Increases Methylation [58]
Serine/threonine-protein kinase pim-1 (PIM1) OTWEKXTU PIM1_HUMAN Increases Expression [76]
Glucose-6-phosphate 1-dehydrogenase (G6PD) OT300SMK G6PD_HUMAN Increases Expression [60]
Steroid hormone receptor ERR1 (ESRRA) OTTDTUSP ERR1_HUMAN Increases Expression [82]
Aromatase (CYP19A1) OTZ6XF74 CP19A_HUMAN Increases Expression [60]
Dystrophin (DMD) OTD21T5J DMD_HUMAN Decreases Methylation [58]
Collagen alpha-2(VI) chain (COL6A2) OTQC6PPO CO6A2_HUMAN Increases Methylation [58]
Creatine kinase B-type (CKB) OTUCKOTT KCRB_HUMAN Increases Expression [60]
Bone morphogenetic protein 4 (BMP4) OTPZMDFH BMP4_HUMAN Increases Expression [60]
Nuclear receptor subfamily 2 group C member 1 (NR2C1) OTJEL7WT NR2C1_HUMAN Increases Methylation [58]
Gamma-interferon-inducible lysosomal thiol reductase (IFI30) OT9DERT1 GILT_HUMAN Decreases Methylation [58]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Increases Expression [60]
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (HSD3B1) OTNAZVKB 3BHS1_HUMAN Increases Methylation [58]
Perforin-1 (PRF1) OTFVXD7H PERF_HUMAN Decreases Expression [74]
Interleukin-1 receptor type 1 (IL1R1) OTTU8959 IL1R1_HUMAN Increases Methylation [58]
Matrix metalloproteinase-9 (MMP9) OTB2QDAV MMP9_HUMAN Increases Expression [60]
Junction plakoglobin (JUP) OTUH7VMO PLAK_HUMAN Increases Methylation [58]
Nucleoside diphosphate kinase A (NME1) OT0NELQ1 NDKA_HUMAN Decreases Expression [59]
Transcription factor 4 (TCF4) OTB9ASTK ITF2_HUMAN Increases Methylation [58]
Platelet-derived growth factor receptor alpha (PDGFRA) OTDJXUCN PGFRA_HUMAN Decreases Methylation [58]
Carboxypeptidase E (CPE) OTXNTV79 CBPE_HUMAN Increases Methylation [58]
Transcription factor JunB (JUNB) OTG2JXV5 JUNB_HUMAN Increases Expression [60]
Gap junction alpha-1 protein (GJA1) OTT94MKL CXA1_HUMAN Decreases Expression [87]
Creatine kinase S-type, mitochondrial (CKMT2) OT1KNPI1 KCRS_HUMAN Increases Methylation [58]
Insulin-like growth factor-binding protein 3 (IGFBP3) OTIX63TX IBP3_HUMAN Increases Methylation [58]
Bone morphogenetic protein 7 (BMP7) OTYATP2K BMP7_HUMAN Increases Expression [60]
Inter-alpha-trypsin inhibitor heavy chain H1 (ITIH1) OTSXJGQF ITIH1_HUMAN Increases Methylation [58]
C-X-C motif chemokine 3 (CXCL3) OTSL94KH CXCL3_HUMAN Increases Expression [76]
Follistatin (FST) OTRIVK9Y FST_HUMAN Increases Expression [76]
Gastricsin (PGC) OTQRITKI PEPC_HUMAN Increases Methylation [58]
B-cell receptor CD22 (CD22) OTXDJR9T CD22_HUMAN Increases Methylation [58]
T-cell surface glycoprotein CD3 zeta chain (CD247) OT45FGUX CD3Z_HUMAN Increases Methylation [58]
Cytoplasmic aconitate hydratase (ACO1) OT2VUR7L ACOHC_HUMAN Increases Methylation [58]
Receptor tyrosine-protein kinase erbB-3 (ERBB3) OTRSST0A ERBB3_HUMAN Decreases Expression [60]
Catechol O-methyltransferase (COMT) OTPWKTQG COMT_HUMAN Increases Expression [60]
Tenascin-X (TNXB) OTVBWAV5 TENX_HUMAN Increases Methylation [58]
Fibulin-1 (FBLN1) OT5MHHOP FBLN1_HUMAN Increases Methylation [58]
Transcription elongation factor A protein 1 (TCEA1) OTBFO594 TCEA1_HUMAN Decreases Methylation [58]
Cerebellin-1 (CBLN1) OTIXFRAG CBLN1_HUMAN Increases Methylation [58]
Brain-derived neurotrophic factor (BDNF) OTLGH7EW BDNF_HUMAN Increases Expression [60]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Decreases Expression [77]
Insulin-like growth factor-binding protein 5 (IGFBP5) OTRE5V0C IBP5_HUMAN Increases Expression [60]
G1/S-specific cyclin-E1 (CCNE1) OTLD7UID CCNE1_HUMAN Decreases Expression [88]
Cyclin-dependent kinase 2 (CDK2) OTB5DYYZ CDK2_HUMAN Increases Expression [88]
Endothelin-1 receptor (EDNRA) OTK9T5O3 EDNRA_HUMAN Increases Methylation [58]
Atypical chemokine receptor 3 (ACKR3) OTA6GA4F ACKR3_HUMAN Decreases Methylation [58]
NF-kappa-B inhibitor alpha (NFKBIA) OTFT924M IKBA_HUMAN Decreases Expression [76]
Integrin beta-7 (ITGB7) OT33UUKU ITB7_HUMAN Increases Methylation [58]
DNA cytosine-5)-methyltransferase 1 (DNMT1) OTM2DGTK DNMT1_HUMAN Decreases Expression [59]
NKG2-C type II integral membrane protein (KLRC2) OTT4N86S NKG2C_HUMAN Increases Methylation [58]
Beta-crystallin B3 (CRYBB3) OTTGTQIQ CRBB3_HUMAN Decreases Methylation [58]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Increases Phosphorylation [89]
Proteasome subunit beta type-8 (PSMB8) OTW5XGMF PSB8_HUMAN Increases Methylation [58]
Choline O-acetyltransferase (CHAT) OTEJWQ45 CLAT_HUMAN Increases Methylation [58]
Gamma-aminobutyric acid receptor subunit rho-2 (GABRR2) OTLDLU1S GBRR2_HUMAN Increases Methylation [58]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Increases Phosphorylation [89]
CCN family member 2 (CCN2) OTC39NSU CCN2_HUMAN Increases Expression [60]
Lysine-specific demethylase 5A (KDM5A) OTLYFX8A KDM5A_HUMAN Increases Methylation [58]
Leukocyte tyrosine kinase receptor (LTK) OT4GPX7K LTK_HUMAN Decreases Methylation [58]
Transmembrane 4 L6 family member 1 (TM4SF1) OTY0ECQN T4S1_HUMAN Increases Methylation [58]
Adenosine receptor A1 (ADORA1) OTI7X39E AA1R_HUMAN Decreases Expression [60]
Fibroblast growth factor 9 (FGF9) OT2SKDGM FGF9_HUMAN Decreases Expression [90]
Sodium- and chloride-dependent taurine transporter (SLC6A6) OT67U7G3 SC6A6_HUMAN Increases Methylation [58]
Gamma-aminobutyric acid receptor subunit alpha-5 (GABRA5) OTBIKWQT GBRA5_HUMAN Decreases Methylation [58]
DnaJ homolog subfamily A member 1 (DNAJA1) OT38BZQQ DNJA1_HUMAN Increases Methylation [58]
3-hydroxyisobutyrate dehydrogenase, mitochondrial (HIBADH) OTCMMMIZ 3HIDH_HUMAN Increases Methylation [58]
Neural cell adhesion molecule L1 (L1CAM) OTNWAQ4Y L1CAM_HUMAN Increases Expression [60]
CD70 antigen (CD70) OTHB2AL1 CD70_HUMAN Increases Methylation [58]
Long-chain-fatty-acid--CoA ligase 1 (ACSL1) OTB06ESI ACSL1_HUMAN Increases Methylation [58]
Cytochrome P450 2C18 (CYP2C18) OTY687L9 CP2CI_HUMAN Increases Methylation [58]
Protein S100-A5 (S100A5) OTCGGL6K S10A5_HUMAN Increases Expression [60]
Protein S100-A3 (S100A3) OTVIZJ2R S10A3_HUMAN Increases Methylation [58]
Dual specificity protein kinase TTK (TTK) OTBY1Z5H TTK_HUMAN Decreases Expression [59]
Prostaglandin G/H synthase 2 (PTGS2) OT75U9M4 PGH2_HUMAN Increases Expression [60]
Nuclear receptor ROR-alpha (RORA) OTGQT12P RORA_HUMAN Increases Methylation [58]
Sodium channel protein type 1 subunit alpha (SCN1A) OTJ9ZTYI SCN1A_HUMAN Increases Methylation [58]
Hepatocyte nuclear factor 1-beta (HNF1B) OTSYIC3T HNF1B_HUMAN Decreases Expression [91]
Transcription factor SOX-6 (SOX6) OTT0W0LE SOX6_HUMAN Increases Methylation [58]
Aryl hydrocarbon receptor (AHR) OTFE4EYE AHR_HUMAN Increases Expression [60]
Receptor-type tyrosine-protein kinase FLT3 (FLT3) OTMSRYMK FLT3_HUMAN Increases Methylation [58]
Breast cancer type 1 susceptibility protein (BRCA1) OT5BN6VH BRCA1_HUMAN Decreases Expression [77]
Collagen alpha-1(XVIII) chain (COL18A1) OTJFUH6O COIA1_HUMAN Increases Methylation [58]
Pre-B-cell leukemia transcription factor 3 (PBX3) OT8WMVM4 PBX3_HUMAN Increases Methylation [58]
Glutamate receptor 3 (GRIA3) OT34CNBR GRIA3_HUMAN Decreases Methylation [58]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PIK3CB) OTO8JQJA PK3CB_HUMAN Increases Methylation [58]
Phosphatidylinositol 4-kinase alpha (PI4KA) OT2L2G6C PI4KA_HUMAN Increases Methylation [58]
Dipeptidyl aminopeptidase-like protein 6 (DPP6) OTWW3H0K DPP6_HUMAN Decreases Methylation [58]
Tyrosine-protein kinase Tec (TEC) OTU6QJAJ TEC_HUMAN Increases Methylation [58]
Condensin-2 complex subunit D3 (NCAPD3) OTOZY2UL CNDD3_HUMAN Increases Methylation [58]
Cathepsin O (CTSO) OTFL6VRO CATO_HUMAN Increases Expression [60]
Aldehyde dehydrogenase family 3 member B1 (ALDH3B1) OT5NEUQE AL3B1_HUMAN Increases Methylation [58]
Tumor necrosis factor receptor superfamily member 4 (TNFRSF4) OTDK74C0 TNR4_HUMAN Decreases Methylation [58]
Neuronal acetylcholine receptor subunit alpha-4 (CHRNA4) OT1H0ZXC ACHA4_HUMAN Increases Methylation [58]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Increases Expression [80]
5-hydroxytryptamine receptor 5A (HTR5A) OTRKPCQV 5HT5A_HUMAN Increases Methylation [58]
Tumor necrosis factor ligand superfamily member 6 (FASLG) OTZARCHH TNFL6_HUMAN Decreases Methylation [58]
G protein-activated inward rectifier potassium channel 2 (KCNJ6) OTDE1FT0 KCNJ6_HUMAN Increases Methylation [58]
Retinoic acid receptor RXR-gamma (RXRG) OT254B09 RXRG_HUMAN Decreases Methylation [58]
Nuclear receptor-interacting protein 1 (NRIP1) OTIZOJQV NRIP1_HUMAN Decreases Expression [60]
Protein PRRC2A (PRRC2A) OTBX6FM5 PRC2A_HUMAN Increases Methylation [58]
Protein farnesyltransferase subunit beta (CHURC1-FNTB) OT34M7E3 FNTB_HUMAN Increases Methylation [58]
Protein phosphatase 1F (PPM1F) OTU0MVR7 PPM1F_HUMAN Increases Methylation [58]
Casein kinase I isoform epsilon (CSNK1E) OTF0UXX6 KC1E_HUMAN Increases Methylation [58]
CCAAT/enhancer-binding protein delta (CEBPD) OTNBIPMY CEBPD_HUMAN Increases Methylation [58]
Nuclear pore complex protein Nup153 (NUP153) OTCAS0AR NU153_HUMAN Increases Methylation [58]
Protein Tob1 (TOB1) OTNW949D TOB1_HUMAN Increases Methylation [58]
Lipopolysaccharide-responsive and beige-like anchor protein (LRBA) OTOUZN9G LRBA_HUMAN Increases Methylation [58]
Transcription activator BRG1 (SMARCA4) OT68WOPQ SMCA4_HUMAN Decreases Expression [79]
Nuclear receptor subfamily 0 group B member 1 (NR0B1) OTC8P9GN NR0B1_HUMAN Increases Expression [60]
Serine/threonine-protein kinase Nek2 (NEK2) OT1H27HO NEK2_HUMAN Decreases Expression [59]
Beta-chimaerin (CHN2) OTSSDPWN CHIO_HUMAN Increases Methylation [58]
Ephrin-A5 (EFNA5) OTOH4DRR EFNA5_HUMAN Increases Expression [60]
Stanniocalcin-1 (STC1) OTGVVXYF STC1_HUMAN Decreases Methylation [58]
Ataxin-1 (ATXN1) OTQF0HNR ATX1_HUMAN Increases Methylation [58]
Huntingtin-associated protein 1 (HAP1) OT6SG0JQ HAP1_HUMAN Increases Methylation [58]
Myomesin-2 (MYOM2) OTD2UOXW MYOM2_HUMAN Increases Methylation [58]
Tyrosine-protein phosphatase non-receptor type 5 (PTPN5) OT2H1KDK PTN5_HUMAN Increases Methylation [58]
Protein AF-10 (MLLT10) OTURMDV7 AF10_HUMAN Increases Methylation [58]
Adenosine kinase (ADK) OTXR6VDI ADK_HUMAN Increases Methylation [58]
Hepatocyte nuclear factor 3-alpha (FOXA1) OTEBY0TD FOXA1_HUMAN Increases Expression [60]
Galectin-4 (LGALS4) OTKQCG0H LEG4_HUMAN Increases Methylation [58]
Histone deacetylase 4 (HDAC4) OTQNGD32 HDAC4_HUMAN Increases Methylation [58]
Claudin-17 (CLDN17) OTQCEYBY CLD17_HUMAN Decreases Methylation [58]
Breast cancer anti-estrogen resistance protein 1 (BCAR1) OTKT2C2N BCAR1_HUMAN Increases Expression [60]
Pro-neuregulin-3, membrane-bound isoform (NRG3) OTIFZ5CT NRG3_HUMAN Increases Methylation [58]
Claudin-2 (CLDN2) OTRF3D6Y CLD2_HUMAN Decreases Methylation [58]
Neurexin-1-beta (NRXN1) OTJN1JQA NRX1B_HUMAN Decreases Methylation [58]
CD81 antigen (CD81) OTQFXNAZ CD81_HUMAN Increases Methylation [58]
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN) OTOWDUNT PTEN_HUMAN Increases Methylation [58]
26S proteasome complex subunit SEM1 (SEM1) OTASLBM1 SEM1_HUMAN Decreases Methylation [58]
Protein max (MAX) OTKZ0YKM MAX_HUMAN Increases Methylation [58]
Small ribosomal subunit protein eS7 (RPS7) OTIK25WI RS7_HUMAN Increases Methylation [58]
Small nuclear ribonucleoprotein G (SNRPG) OTWX4XK1 RUXG_HUMAN Increases Methylation [58]
DNA-directed RNA polymerases I, II, and III subunit RPABC5 (POLR2L) OTSSOMUP RPAB5_HUMAN Decreases Methylation [58]
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform (PPP2R2A) OT9297OG 2ABA_HUMAN Increases Methylation [58]
Inward rectifier potassium channel 2 (KCNJ2) OT2OQEZS KCNJ2_HUMAN Decreases Methylation [58]
Tropomyosin alpha-4 chain (TPM4) OTN4YLYR TPM4_HUMAN Increases Methylation [58]
Actin, alpha skeletal muscle (ACTA1) OTOVGLPG ACTS_HUMAN Increases Methylation [58]
Reelin (RELN) OTLKMW1O RELN_HUMAN Increases Methylation [58]
C-C motif chemokine 20 (CCL20) OTUCJY4N CCL20_HUMAN Increases Expression [76]
Small ribosomal subunit protein uS9m (MRPS9) OTD4XOHS RT09_HUMAN Decreases Methylation [58]
Mothers against decapentaplegic homolog 3 (SMAD3) OTNA96MR SMAD3_HUMAN Increases Methylation [58]
Calcium-transporting ATPase type 2C member 1 (ATP2C1) OTQN51T3 AT2C1_HUMAN Affects Methylation [58]
Phospholipid-transporting ATPase IH (ATP11A) OT7M9ZDK AT11A_HUMAN Increases Methylation [58]
Cytochrome c (CYCS) OTBFALJD CYC_HUMAN Increases Expression [82]
Cyclin-dependent kinase 6 (CDK6) OTR95N0X CDK6_HUMAN Increases Expression [79]
Transcription factor E2F1 (E2F1) OTLKYBBC E2F1_HUMAN Decreases Expression [88]
Runt-related transcription factor 1 (RUNX1) OTU7J84H RUNX1_HUMAN Decreases Methylation [58]
Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1) OTCO26FV HMCS1_HUMAN Increases Methylation [58]
ATP-dependent 6-phosphofructokinase, platelet type (PFKP) OTFP7AA8 PFKAP_HUMAN Increases Methylation [58]
DNA-binding protein SATB1 (SATB1) OTT7SUVW SATB1_HUMAN Decreases Methylation [58]
Zinc finger protein basonuclin-1 (BNC1) OTGJ5WUF BNC1_HUMAN Decreases Methylation [58]
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1) OTEUYEW6 ROR1_HUMAN Increases Methylation [58]
2-oxoglutarate dehydrogenase complex component E1 (OGDH) OTHGTQWF ODO1_HUMAN Increases Methylation [58]
Pro-neuregulin-1, membrane-bound isoform (NRG1) OTZO6F1X NRG1_HUMAN Increases Methylation [58]
Dystonin (DST) OTHZBM4X DYST_HUMAN Increases Methylation [58]
Caveolin-1 (CAV1) OTEZUR1L CAV1_HUMAN Decreases Expression [60]
Trefoil factor 2 (TFF2) OTRXB19X TFF2_HUMAN Decreases Expression [92]
Early growth response protein 4 (EGR4) OT4R3ECK EGR4_HUMAN Increases Methylation [58]
Focal adhesion kinase 1 (PTK2) OT3Q1JDY FAK1_HUMAN Increases Degradation [89]
Homeobox protein engrailed-1 (EN1) OT2DKIDK HME1_HUMAN Decreases Methylation [58]
Recombining binding protein suppressor of hairless (RBPJ) OTD7CUG0 SUH_HUMAN Increases Methylation [58]
DNA repair protein RAD51 homolog 1 (RAD51) OTNVWGC1 RAD51_HUMAN Decreases Expression [59]
Collagen alpha-1(XVI) chain (COL16A1) OTOWKUO2 COGA1_HUMAN Increases Methylation [58]
Trichohyalin (TCHH) OT4J7EFT TRHY_HUMAN Decreases Methylation [58]
Forkhead box protein M1 (FOXM1) OT5887KR FOXM1_HUMAN Decreases Expression [59]
3',5'-cyclic-AMP phosphodiesterase 4D (PDE4D) OT1RWFV0 PDE4D_HUMAN Decreases Methylation [58]
Transmembrane protein 62 (TMEM62) OTJ4SPCM TMM62_HUMAN Increases Methylation [58]
General transcription factor 3C polypeptide 1 (GTF3C1) OT7JK0RG TF3C1_HUMAN Increases Methylation [58]
Calcium-activated potassium channel subunit alpha-1 (KCNMA1) OTNYXOZO KCMA1_HUMAN Increases Methylation [58]
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (SMARCB1) OT2LP7LJ SNF5_HUMAN Increases Expression [79]
Cell division cycle protein 20 homolog (CDC20) OTCOEZRV CDC20_HUMAN Decreases Expression [59]
Follistatin-related protein 1 (FSTL1) OT6KEZUD FSTL1_HUMAN Increases Methylation [58]
Splicing factor, suppressor of white-apricot homolog (SFSWAP) OT7H3ETA SFSWA_HUMAN Increases Methylation [58]
Heat shock protein 75 kDa, mitochondrial (TRAP1) OTNG0L8J TRAP1_HUMAN Increases Methylation [58]
Ankyrin-3 (ANK3) OTJ3IRBP ANK3_HUMAN Increases Methylation [58]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 (BNIP2) OTVZD4H6 BNIP2_HUMAN Increases Methylation [58]
Interleukin-24 (IL24) OT4VUWH1 IL24_HUMAN Increases Expression [76]
Semaphorin-3B (SEMA3B) OTCZCPMS SEM3B_HUMAN Increases Methylation [58]
Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1) OTXNGZCG MD2L1_HUMAN Decreases Expression [59]
Growth factor receptor-bound protein 10 (GRB10) OTCKXGRC GRB10_HUMAN Increases Methylation [58]
Metastasis-associated protein MTA1 (MTA1) OTBHW3S9 MTA1_HUMAN Decreases Expression [60]
C-terminal-binding protein 1 (CTBP1) OTVYH2DH CTBP1_HUMAN Decreases Expression [60]
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9) OT70Z4II ADAM9_HUMAN Increases Methylation [58]
snRNA-activating protein complex subunit 2 (SNAPC2) OTN0EL6L SNPC2_HUMAN Increases Methylation [58]
Baculoviral IAP repeat-containing protein 3 (BIRC3) OT3E95KB BIRC3_HUMAN Increases Methylation [58]
Phosphatidylinositol-binding clathrin assembly protein (PICALM) OTQVRPMQ PICAL_HUMAN Increases Methylation [58]
Mastermind-like domain-containing protein 1 (MAMLD1) OT9EVMQY MAMD1_HUMAN Decreases Methylation [58]
Solute carrier family 12 member 1 (SLC12A1) OT6YSX0G S12A1_HUMAN Decreases Methylation [58]
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) OTPLXCDN DYR1A_HUMAN Decreases Methylation [58]
Protein patched homolog 1 (PTCH1) OTMG07H5 PTC1_HUMAN Increases Expression [60]
Nuclear receptor coactivator 4 (NCOA4) OTRVU0UA NCOA4_HUMAN Increases Methylation [58]
ADP-ribosylation factor-related protein 1 (ARFRP1) OTP1OV78 ARFRP_HUMAN Increases Methylation [58]
Protein Shroom2 (SHROOM2) OTZ2FJ7Q SHRM2_HUMAN Increases Methylation [58]
Beta-1-syntrophin (SNTB1) OTSRBECI SNTB1_HUMAN Decreases Methylation [58]
Nuclear nucleic acid-binding protein C1D (C1D) OTI9PMN1 C1D_HUMAN Decreases Methylation [58]
Voltage-dependent L-type calcium channel subunit alpha-1C (CACNA1C) OT6KFNMS CAC1C_HUMAN Increases Methylation [58]
Nidogen-2 (NID2) OTHC33FF NID2_HUMAN Increases Methylation [58]
Protein FAM53B (FAM53B) OTVD7OU6 FA53B_HUMAN Decreases Methylation [58]
Four and a half LIM domains protein 2 (FHL2) OT0OAYWT FHL2_HUMAN Increases Methylation [58]
Dihydropyrimidinase-related protein 3 (DPYSL3) OTINJV20 DPYL3_HUMAN Increases Methylation [58]
Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1) OTD1KRKO DYHC1_HUMAN Increases Methylation [58]
Elongin-A (ELOA) OTOQTF5K ELOA1_HUMAN Increases Methylation [58]
Filamin-C (FLNC) OT3F8J6Y FLNC_HUMAN Decreases Methylation [58]
Histone RNA hairpin-binding protein (SLBP) OTVYYQRT SLBP_HUMAN Decreases Methylation [58]
Inositol 1,4,5-trisphosphate receptor type 2 (ITPR2) OTPHGZ19 ITPR2_HUMAN Increases Methylation [58]
Indian hedgehog protein (IHH) OT1DWGXC IHH_HUMAN Decreases Methylation [58]
Separin (ESPL1) OTMGEVOK ESPL1_HUMAN Decreases Expression [59]
Disco-interacting protein 2 homolog A (DIP2A) OTXPTR8R DIP2A_HUMAN Decreases Methylation [58]
Latent-transforming growth factor beta-binding protein 1 (LTBP1) OTR7Q75L LTBP1_HUMAN Decreases Expression [60]
LIM and SH3 domain protein 1 (LASP1) OT2QIDCL LASP1_HUMAN Increases Methylation [58]
Sodium/hydrogen exchanger 5 (SLC9A5) OTM70CXN SL9A5_HUMAN Decreases Methylation [58]
Protein disulfide-isomerase A6 (PDIA6) OT8YBR17 PDIA6_HUMAN Increases Methylation [58]
Inactive phospholipase C-like protein 1 (PLCL1) OTJL2C79 PLCL1_HUMAN Decreases Methylation [58]
Cyclin-dependent kinase 10 (CDK10) OTKP7TTR CDK10_HUMAN Increases Methylation [58]
Plectin (PLEC) OTU4XDEG PLEC_HUMAN Increases Methylation [58]
Serine/threonine-protein kinase 38 (STK38) OTKMYCYR STK38_HUMAN Increases Methylation [58]
RalA-binding protein 1 (RALBP1) OTBIGB1D RBP1_HUMAN Increases Methylation [58]
Ribosomal protein S6 kinase alpha-2 (RPS6KA2) OTIOYUSU KS6A2_HUMAN Decreases Methylation [58]
Scaffold attachment factor B1 (SAFB) OTGRV2LW SAFB1_HUMAN Increases Methylation [58]
Nuclear receptor subfamily 0 group B member 2 (NR0B2) OT7UVICX NR0B2_HUMAN Decreases Expression [60]
Nuclear receptor coactivator 2 (NCOA2) OTMQFPBB NCOA2_HUMAN Increases Expression [60]
Olfactory receptor 1C1 (OR1C1) OT9WTEX5 OR1C1_HUMAN Decreases Methylation [58]
Mediator of RNA polymerase II transcription subunit 1 (MED1) OTOO24C4 MED1_HUMAN Decreases Expression [60]
ETS-related transcription factor Elf-2 (ELF2) OTEI347F ELF2_HUMAN Increases Methylation [58]
NGFI-A-binding protein 2 (NAB2) OTG4BDF3 NAB2_HUMAN Increases Expression [60]
Nuclear receptor coactivator 1 (NCOA1) OTLIUJQD NCOA1_HUMAN Increases Expression [60]
Glutamate receptor ionotropic, kainate 4 (GRIK4) OTL5EIPA GRIK4_HUMAN Decreases Methylation [58]
NT-3 growth factor receptor (NTRK3) OTII30MY NTRK3_HUMAN Increases Methylation [58]
Meprin A subunit alpha (MEP1A) OTY2Z48T MEP1A_HUMAN Increases Methylation [58]
Receptor-type tyrosine-protein phosphatase O (PTPRO) OTFLKWOY PTPRO_HUMAN Increases Methylation [58]
Cysteine dioxygenase type 1 (CDO1) OTLG1P77 CDO1_HUMAN Decreases Methylation [58]
Protein inscuteable homolog (INSC) OTP16ERR INSC_HUMAN Increases Methylation [58]
Inverted formin-2 (INF2) OT8ZM13C INF2_HUMAN Increases Methylation [58]
Transmembrane protein 266 (TMEM266) OTM17VHD TM266_HUMAN Increases Methylation [58]
ATP-binding cassette sub-family B member 5 (ABCB5) OT8AKP1J ABCB5_HUMAN Increases Methylation [58]
CST complex subunit CTC1 (CTC1) OTRJY7QD CTC1_HUMAN Decreases Methylation [58]
FH1/FH2 domain-containing protein 3 (FHOD3) OT1WUBQX FHOD3_HUMAN Decreases Methylation [58]
Carcinoembryonic antigen-related cell adhesion molecule 16 (CEACAM16) OTUMUSY0 CEA16_HUMAN Increases Methylation [58]
Leucine-rich repeat flightless-interacting protein 1 (LRRFIP1) OTN7XAUD LRRF1_HUMAN Decreases Methylation [58]
Polycomb group RING finger protein 3 (PCGF3) OTY7TPPZ PCGF3_HUMAN Increases Methylation [58]
MAP7 domain-containing protein 1 (MAP7D1) OTMGC8N9 MA7D1_HUMAN Decreases Methylation [58]
Mucin-like protein 3 (MUCL3) OTGAD3I0 MUCL3_HUMAN Increases Methylation [58]
Cilia- and flagella-associated protein 100 (CFAP100) OTHHFM2Z CP100_HUMAN Increases Methylation [58]
Spermatogenesis-associated serine-rich protein 1 (SPATS1) OTPUXCSA SPAS1_HUMAN Decreases Methylation [58]
Cryptochrome-2 (CRY2) OTERZ93T CRY2_HUMAN Increases Methylation [58]
Ceramide kinase-like protein (CERKL) OTG4YGBR CERKL_HUMAN Decreases Methylation [58]
NAD kinase 2, mitochondrial (NADK2) OT1I8GDE NAKD2_HUMAN Decreases Methylation [58]
Glucoside xylosyltransferase 1 (GXYLT1) OTI5MDYW GXLT1_HUMAN Increases Methylation [58]
Protein GREB1 (GREB1) OTU6ZA26 GREB1_HUMAN Decreases Expression [60]
PAN2-PAN3 deadenylation complex catalytic subunit PAN2 (PAN2) OTB65N2I PAN2_HUMAN Increases Methylation [58]
Acylglycerol kinase, mitochondrial (AGK) OTJGWBYT AGK_HUMAN Increases Methylation [58]
Fibulin-7 (FBLN7) OT1XRDP6 FBLN7_HUMAN Increases Methylation [58]
FRAS1-related extracellular matrix protein 1 (FREM1) OTMHRV87 FREM1_HUMAN Increases Methylation [58]
SH3 domain-containing protein 19 (SH3D19) OTVU3VS2 SH319_HUMAN Increases Methylation [58]
Protein crumbs homolog 2 (CRB2) OTG0L2CE CRUM2_HUMAN Increases Expression [60]
NHL repeat-containing protein 3 (NHLRC3) OTBI6YSN NHLC3_HUMAN Increases Methylation [58]
Dedicator of cytokinesis protein 11 (DOCK11) OTFSTN6A DOC11_HUMAN Increases Methylation [58]
Protein FAM78A (FAM78A) OTDZ36V8 FA78A_HUMAN Decreases Methylation [58]
EF-hand domain-containing protein 1 (EFHC1) OTS9IBNE EFHC1_HUMAN Increases Methylation [58]
Calcium homeostasis modulator protein 4 (CALHM4) OTUDL2HG CAHM4_HUMAN Increases Methylation [58]
Tubulin-specific chaperone cofactor E-like protein (TBCEL) OT2PZLLL TBCEL_HUMAN Increases Methylation [58]
Mucin-21 (MUC21) OTQ8GP5L MUC21_HUMAN Increases Methylation [58]
Uncharacterized protein C6orf132 (C6ORF132) OTMH4S7O CF132_HUMAN Increases Methylation [58]
Calmodulin-regulated spectrin-associated protein 1 (CAMSAP1) OT1N2182 CAMP1_HUMAN Increases Methylation [58]
Uncharacterized protein C1orf185 (C1ORF185) OT32C5NW CA185_HUMAN Increases Methylation [58]
Coiled-coil domain-containing protein 18 (CCDC18) OT0S9DA2 CCD18_HUMAN Decreases Methylation [58]
Growth hormone-regulated TBC protein 1 (GRTP1) OT8HORRZ GRTP1_HUMAN Increases Methylation [58]
Protein sel-1 homolog 2 (SEL1L2) OTSBDWIG SE1L2_HUMAN Increases Methylation [58]
E3 ubiquitin-protein ligase RNF220 (RNF220) OT2FIEXO RN220_HUMAN Increases Methylation [58]
Forkhead box protein B2 (FOXB2) OTJE3RRR FOXB2_HUMAN Increases Methylation [58]
Armadillo repeat-containing protein 3 (ARMC3) OTF6M9MM ARMC3_HUMAN Increases Methylation [58]
Anoctamin-1 (ANO1) OTSREUNI ANO1_HUMAN Increases Methylation [58]
Meteorin-like protein (METRNL) OTB0DDL0 METRL_HUMAN Increases Methylation [58]
DDB1- and CUL4-associated factor 15 (DCAF15) OTWBXZ0E DCA15_HUMAN Increases Methylation [58]
Autophagy-related protein 16-1 (ATG16L1) OTEOYC5D A16L1_HUMAN Increases Methylation [58]
Tensin-3 (TNS3) OTPG2D8Z TENS3_HUMAN Increases Methylation [58]
Coiled-coil domain-containing protein 102B (CCDC102B) OTVDZVD0 C102B_HUMAN Decreases Methylation [58]
Cytosolic phospholipase A2 zeta (PLA2G4F) OT8MUO5U PA24F_HUMAN Increases Methylation [58]
NADH-cytochrome b5 reductase 2 (CYB5R2) OTTLM7XN NB5R2_HUMAN Increases Methylation [58]
Bridge-like lipid transfer protein family member 3A (BLTP3A) OTRLMP17 BLT3A_HUMAN Increases Methylation [58]
Capping protein, Arp2/3 and myosin-I linker protein 2 (CARMIL2) OTV5S1J2 CARL2_HUMAN Increases Methylation [58]
Fatty-acid amide hydrolase 2 (FAAH2) OTS6LX01 FAAH2_HUMAN Decreases Methylation [58]
GRAM domain-containing protein 4 (GRAMD4) OT1HXEPM GRAM4_HUMAN Decreases Methylation [58]
Pleckstrin homology domain-containing family A member 7 (PLEKHA7) OTNUMAZ0 PKHA7_HUMAN Increases Methylation [58]
Beta-1,4-N-acetylgalactosaminyltransferase 3 (B4GALNT3) OT6BFB22 B4GN3_HUMAN Decreases Methylation [58]
Teneurin-4 (TENM4) OT91K3FC TEN4_HUMAN Increases Methylation [58]
SANT and BTB domain regulator of class switch recombination (SANBR) OTY7ZODH SANBR_HUMAN Decreases Methylation [58]
Homeobox-containing protein 1 (HMBOX1) OTPKTBVI HMBX1_HUMAN Increases Methylation [58]
TELO2-interacting protein 2 (TTI2) OTU7TQCO TTI2_HUMAN Decreases Methylation [58]
Phostensin (PPP1R18) OT0JVGOZ PPR18_HUMAN Decreases Methylation [58]
Phospholipase B1, membrane-associated (PLB1) OTZ6TTYV PLB1_HUMAN Increases Methylation [58]
Enhancer of mRNA-decapping protein 4 (EDC4) OTBBNIUJ EDC4_HUMAN Increases Methylation [58]
Uncharacterized protein C16orf46 (C16ORF46) OT8FDG3A CP046_HUMAN Increases Methylation [58]
Serine/threonine-protein kinase Nek5 (NEK5) OTHDXCYZ NEK5_HUMAN Increases Methylation [58]
Neuroblastoma breakpoint family member 10 (NBPF10) OTGOCELY NBPFA_HUMAN Affects Methylation [58]
NIPA-like protein 3 (NIPAL3) OTI858LL NPAL3_HUMAN Increases Methylation [58]
Cytochrome b5 domain-containing protein 1 (CYB5D1) OTSZWTPT CB5D1_HUMAN Increases Methylation [58]
E3 ubiquitin-protein ligase RFWD3 (RFWD3) OTDUULBQ RFWD3_HUMAN Decreases Methylation [58]
tRNA methyltransferase 10 homolog B (TRMT10B) OT3EJP6J TM10B_HUMAN Increases Methylation [58]
Kv channel-interacting protein 4 (KCNIP4) OTB1BS0X KCIP4_HUMAN Decreases Methylation [58]
Docking protein 6 (DOK6) OTX55OIF DOK6_HUMAN Affects Methylation [58]
Solute carrier family 25 member 47 (SLC25A47) OT5NGRWC S2547_HUMAN Increases Methylation [58]
SCAN domain-containing protein 3 (SCAND3) OTIIMBQL SCND3_HUMAN Decreases Methylation [58]
Opsin-5 (OPN5) OTCYGHDA OPN5_HUMAN Decreases Methylation [58]
CREB-regulated transcription coactivator 3 (CRTC3) OTVIGVUW CRTC3_HUMAN Increases Methylation [58]
Golgi-associated kinase 1B (GASK1B) OT2HPHEI GAK1B_HUMAN Decreases Methylation [58]
Transmembrane and coiled-coil domain-containing protein 3 (TMCO3) OTYW1KP2 TMCO3_HUMAN Increases Methylation [58]
Protein SNORC (SNORC) OTY3IJK5 SNORC_HUMAN Increases Methylation [58]
Inactive serine protease PAMR1 (PAMR1) OT83ZH5U PAMR1_HUMAN Increases Methylation [58]
Serine/threonine-protein kinase LMTK1 (AATK) OTVHAX5N LMTK1_HUMAN Decreases Methylation [58]
Metastasis-associated in colon cancer protein 1 (MACC1) OTV3DLX0 MACC1_HUMAN Decreases Methylation [58]
Ferric-chelate reductase 1 (FRRS1) OTQDEGEB FRRS1_HUMAN Increases Methylation [58]
Neurobeachin-like protein 2 (NBEAL2) OTMCAXWR NBEL2_HUMAN Increases Methylation [58]
Transmembrane protein 182 (TMEM182) OTVDIS2V TM182_HUMAN Increases Methylation [58]
RING finger protein 207 (RNF207) OT9AYVGV RN207_HUMAN Increases Methylation [58]
Protein ITPRID1 (ITPRID1) OT9MH0BX ITPI1_HUMAN Increases Methylation [58]
Colorectal cancer-associated protein 1 (COLCA1) OT8BP6UD COLC1_HUMAN Decreases Methylation [58]
Protein shisa-6 (SHISA6) OTWBCJ8O SHSA6_HUMAN Decreases Methylation [58]
Major facilitator superfamily domain-containing protein 6 (MFSD6) OTQ6KAV1 MFSD6_HUMAN Increases Methylation [58]
BEN domain-containing protein 4 (BEND4) OT7Z1422 BEND4_HUMAN Increases Methylation [58]
Tumor protein p63-regulated gene 1 protein (TPRG1) OTS48DQM TPRG1_HUMAN Increases Methylation [58]
Phosphoinositide 3-kinase adapter protein 1 (PIK3AP1) OTMW1B47 BCAP_HUMAN Increases Methylation [58]
Coiled-coil domain-containing protein 149 (CCDC149) OT7S7MU9 CC149_HUMAN Decreases Methylation [58]
Cytochrome P450 4V2 (CYP4V2) OTQKNK0D CP4V2_HUMAN Decreases Methylation [58]
MOB kinase activator 2 (MOB2) OTMBE0NS MOB2_HUMAN Affects Methylation [58]
RING finger protein 44 (RNF44) OTGWL4U4 RNF44_HUMAN Increases Methylation [58]
DET1 homolog (DET1) OTHYSDX3 DET1_HUMAN Increases Methylation [58]
MOB kinase activator 1B (MOB1B) OTRE19ZS MOB1B_HUMAN Increases Methylation [58]
Keratin, type I cytoskeletal 26 (KRT26) OTLAXIN0 K1C26_HUMAN Increases Methylation [58]
CUB and sushi domain-containing protein 2 (CSMD2) OT541Z3W CSMD2_HUMAN Increases Methylation [58]
Protein lifeguard 1 (GRINA) OTMC1O66 LFG1_HUMAN Increases Methylation [58]
Podocan (PODN) OTV3P7P5 PODN_HUMAN Increases Methylation [58]
Protein sidekick-1 (SDK1) OTX26906 SDK1_HUMAN Increases Methylation [58]
Ankyrin repeat and sterile alpha motif domain-containing protein 1B (ANKS1B) OT26DGM9 ANS1B_HUMAN Increases Methylation [58]
Transcription factor AP-2-delta (TFAP2D) OT71O6YN AP2D_HUMAN Decreases Methylation [58]
Pleckstrin homology domain-containing family H member 3 (PLEKHH3) OTREOQBO PKHH3_HUMAN Increases Methylation [58]
Cytokine-dependent hematopoietic cell linker (CLNK) OTOWK51S CLNK_HUMAN Decreases Methylation [58]
Calcium/calmodulin-dependent protein kinase II inhibitor 1 (CAMK2N1) OTKCR5XL CK2N1_HUMAN Increases Methylation [58]
Uncharacterized protein C11orf96 (C11ORF96) OTEQU0V7 CK096_HUMAN Increases Methylation [58]
Polypeptide N-acetylgalactosaminyltransferase 5 (GALNT5) OTCV61V1 GALT5_HUMAN Increases Methylation [58]
Pleckstrin homology-like domain family B member 2 (PHLDB2) OTDKMB2G PHLB2_HUMAN Increases Methylation [58]
Protein hinderin (KIAA1328) OT2RMGGB K1328_HUMAN Increases Methylation [58]
TBC1 domain family member 1 (TBC1D1) OTI9V7B0 TBCD1_HUMAN Increases Methylation [58]
Store-operated calcium entry regulator STIMATE (STIMATE) OTEDLKEW STIMA_HUMAN Increases Methylation [58]
Armadillo-like helical domain-containing protein 4 (ARMH4) OT25GBJM ARMD4_HUMAN Increases Methylation [58]
Protein polybromo-1 (PBRM1) OT39WUR9 PB1_HUMAN Decreases Methylation [58]
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (MAGI2) OTXDDKZS MAGI2_HUMAN Decreases Methylation [58]
Reticulon-4 receptor-like 1 (RTN4RL1) OTDKKOE7 R4RL1_HUMAN Increases Methylation [58]
Telomerase-binding protein EST1A (SMG6) OTRCEJQL EST1A_HUMAN Increases Methylation [58]
Leucine zipper protein 1 (LUZP1) OTQV3VZM LUZP1_HUMAN Increases Methylation [58]
Serine incorporator 5 (SERINC5) OT3COPVF SERC5_HUMAN Increases Methylation [58]
Myotubularin-related protein 13 (SBF2) OTBB8NO8 MTMRD_HUMAN Increases Methylation [58]
Histone-arginine methyltransferase CARM1 (CARM1) OT0IPRVR CARM1_HUMAN Increases Expression [60]
Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) OTHCYR6Y ANKL2_HUMAN Increases Methylation [58]
Angiopoietin-related protein 5 (ANGPTL5) OTC6AFVO ANGL5_HUMAN Increases Methylation [58]
Cilium assembly protein DZIP1 (DZIP1) OTBVPO66 DZIP1_HUMAN Increases Methylation [58]
Probable guanine nucleotide exchange factor MCF2L2 (MCF2L2) OTOGFMIH MF2L2_HUMAN Increases Methylation [58]
Protein O-mannosyl-transferase TMTC1 (TMTC1) OTZ7NW96 TMTC1_HUMAN Increases Methylation [58]
Neuron navigator 3 (NAV3) OT97M1TR NAV3_HUMAN Decreases Methylation [58]
Glycerate kinase (GLYCTK) OTVTBNSM GLCTK_HUMAN Increases Methylation [58]
Aprataxin and PNK-like factor (APLF) OTYUR3AH APLF_HUMAN Increases Expression [60]
Adhesion G protein-coupled receptor A3 (ADGRA3) OTPJEV0S AGRA3_HUMAN Increases Methylation [58]
Proton-coupled zinc antiporter SLC30A8 (SLC30A8) OTF0FG5K ZNT8_HUMAN Increases Methylation [58]
Sphingosine-1-phosphate phosphatase 2 (SGPP2) OTIDIJCR SGPP2_HUMAN Increases Methylation [58]
Neuronal PAS domain-containing protein 3 (NPAS3) OT8D1ILB NPAS3_HUMAN Increases Methylation [58]
POU domain class 2-associating factor 2 (POU2AF2) OTPBW3NC OCAT1_HUMAN Increases Methylation [58]
Lamin tail domain-containing protein 2 (LMNTD2) OTKGJ1ST LMTD2_HUMAN Increases Methylation [58]
Nucleotidyltransferase MB21D2 (MB21D2) OT5C4VVU M21D2_HUMAN Increases Methylation [58]
PEX5-related protein (PEX5L) OTLR4HSR PEX5R_HUMAN Decreases Methylation [58]
Proline-, glutamic acid- and leucine-rich protein 1 (PELP1) OTVXQNOT PELP1_HUMAN Decreases Expression [60]
Voltage-dependent calcium channel subunit alpha-2/delta-3 (CACNA2D3) OTEH9HGE CA2D3_HUMAN Increases Methylation [58]
Transcription initiation factor TFIID subunit 1-like (TAF1L) OT9Z7EVA TAF1L_HUMAN Increases Methylation [58]
Leucine-rich repeat LGI family member 2 (LGI2) OTFJ2ZSG LGI2_HUMAN Decreases Methylation [58]
Regulatory-associated protein of mTOR (RPTOR) OT4TQZ9F RPTOR_HUMAN Increases Methylation [58]
UPF0462 protein C4orf33 (C4ORF33) OT3O3FC3 CD033_HUMAN Decreases Methylation [58]
Mesoderm induction early response protein 2 (MIER2) OTYURSWD MIER2_HUMAN Increases Methylation [58]
Xylosyl- and glucuronyltransferase LARGE2 (LARGE2) OT5BZS3J LARG2_HUMAN Increases Methylation [58]
Putative transporter SVOPL (SVOPL) OTJ4G2ND SVOPL_HUMAN Increases Methylation [58]
Follistatin-related protein 5 (FSTL5) OT18C29S FSTL5_HUMAN Decreases Methylation [58]
ADAMTS-like protein 1 (ADAMTSL1) OTBNYF3F ATL1_HUMAN Increases Methylation [58]
EF-hand domain-containing family member B (EFHB) OT83HFEP EFHB_HUMAN Increases Methylation [58]
Protein BANP (BANP) OT1JMTBD BANP_HUMAN Increases Methylation [58]
Sodium-dependent lysophosphatidylcholine symporter 1 (MFSD2A) OTVG1VG0 NLS1_HUMAN Increases Methylation [58]
Kyphoscoliosis peptidase (KY) OTK1L8VX KY_HUMAN Increases Methylation [58]
Clarin-3 (CLRN3) OTZDNL65 CLRN3_HUMAN Increases Methylation [58]
Exophilin-5 (EXPH5) OTOMXDUO EXPH5_HUMAN Decreases Methylation [58]
Nesprin-1 (SYNE1) OTSBSLUH SYNE1_HUMAN Increases Methylation [58]
Metalloreductase STEAP2 (STEAP2) OTGE9ETG STEA2_HUMAN Decreases Methylation [58]
Kelch repeat and BTB domain-containing protein 8 (KBTBD8) OTO8X1UF KBTB8_HUMAN Decreases Methylation [58]
Neuroligin-2 (NLGN2) OTHDYL3H NLGN2_HUMAN Increases Methylation [58]
Serine/threonine-protein kinase Nek11 (NEK11) OTMYENTC NEK11_HUMAN Decreases Methylation [58]
Olfactory receptor 5T1 (OR5T1) OTJT8C6S OR5T1_HUMAN Decreases Methylation [58]
Olfactory receptor 2AK2 (OR2AK2) OTNG4ZS1 O2AK2_HUMAN Increases Methylation [58]
Olfactory receptor 8J3 (OR8J3) OTLQYWZG OR8J3_HUMAN Decreases Methylation [58]
Olfactory receptor 8J1 (OR8J1) OTWWGQW0 OR8J1_HUMAN Decreases Methylation [58]
Olfactory receptor 4S2 (OR4S2) OTHEO86H OR4S2_HUMAN Decreases Methylation [58]
LHFPL tetraspan subfamily member 5 protein (LHFPL5) OTNDTO5B LHPL5_HUMAN Decreases Methylation [58]
SWI/SNF complex subunit SMARCC2 (SMARCC2) OTC5SNMZ SMRC2_HUMAN Decreases Expression [79]
Iron-sulfur cluster transfer protein NUBPL (NUBPL) OTQMCSXT NUBPL_HUMAN Increases Methylation [58]
DEP domain-containing mTOR-interacting protein (DEPTOR) OTCBP1BT DPTOR_HUMAN Increases Methylation [58]
T-cell immunomodulatory protein (ITFG1) OTX0PCR3 TIP_HUMAN Decreases Methylation [58]
Glutamate receptor ionotropic, NMDA 3A (GRIN3A) OTQS9GYY NMD3A_HUMAN Increases Methylation [58]
Transmembrane channel-like protein 1 (TMC1) OTHYH8MU TMC1_HUMAN Increases Methylation [58]
Polycystin-1-like protein 1 (PKD1L1) OTLAARJ1 PK1L1_HUMAN Increases Methylation [58]
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 (ASAP3) OTQB4H1J ASAP3_HUMAN Increases Methylation [58]
Epidermal growth factor receptor kinase substrate 8-like protein 3 (EPS8L3) OT7XYA2T ES8L3_HUMAN Increases Methylation [58]
Epidermal growth factor receptor kinase substrate 8-like protein 1 (EPS8L1) OT83O8WI ES8L1_HUMAN Decreases Methylation [58]
Importin-4 (IPO4) OT2N5020 IPO4_HUMAN Increases Methylation [58]
Membrane progestin receptor beta (PAQR8) OTGZ8W9F PAQR8_HUMAN Decreases Methylation [58]
Dual specificity protein phosphatase 19 (DUSP19) OT0RRSG9 DUS19_HUMAN Decreases Methylation [58]
Splicing factor Cactin (CACTIN) OTO7UVK7 CATIN_HUMAN Increases Methylation [58]
AFG1-like ATPase (AFG1L) OTQ9VV5T AFG1L_HUMAN Increases Methylation [58]
Ankyrin repeat and SOCS box protein 10 (ASB10) OTYSZ9V6 ASB10_HUMAN Increases Methylation [58]
Autism susceptibility gene 2 protein (AUTS2) OTAEXHSC AUTS2_HUMAN Increases Methylation [58]
Cysteine/serine-rich nuclear protein 3 (CSRNP3) OTOANEHZ CSRN3_HUMAN Increases Methylation [58]
Phosphoinositide 3-kinase regulatory subunit 5 (PIK3R5) OT4LNXJU PI3R5_HUMAN Decreases Methylation [58]
Piezo-type mechanosensitive ion channel component 1 (PIEZO1) OTBG1FU4 PIEZ1_HUMAN Increases Methylation [58]
Phosphatidate phosphatase LPIN2 (LPIN2) OTRRTMXX LPIN2_HUMAN Increases Methylation [58]
Sorting nexin-19 (SNX19) OTGNS3HG SNX19_HUMAN Decreases Methylation [58]
Engulfment and cell motility protein 1 (ELMO1) OTY2ORXK ELMO1_HUMAN Decreases Methylation [58]
Delta-sarcoglycan (SGCD) OTRBL3NQ SGCD_HUMAN Increases Methylation [58]
A-kinase anchor protein 1, mitochondrial (AKAP1) OTIIB2JB AKAP1_HUMAN Increases Expression [60]
Estrogen receptor beta (ESR2) OTXNR2WQ ESR2_HUMAN Increases Expression [60]
Transcription initiation factor TFIID subunit 4B (TAF4B) OTCICY31 TAF4B_HUMAN Increases Methylation [58]
General transcription factor IIH subunit 4 (GTF2H4) OTPD1DIU TF2H4_HUMAN Decreases Methylation [58]
Histone acetyltransferase KAT6A (KAT6A) OT4TSQLG KAT6A_HUMAN Decreases Methylation [58]
Neuronal cell adhesion molecule (NRCAM) OT80HHQ2 NRCAM_HUMAN Increases Methylation [58]
Bcl-2-like protein 2 (BCL2L2) OTMKVO0J B2CL2_HUMAN Increases Expression [60]
Caspase-10 (CASP10) OTE6J88E CASPA_HUMAN Increases Methylation [58]
ATP-binding cassette sub-family C member 2 (ABCC2) OTJSIGV5 MRP2_HUMAN Increases Expression [84]
Fibroblast growth factor 13 (FGF13) OTHNNVSG FGF13_HUMAN Increases Methylation [58]
SWI/SNF complex subunit SMARCC1 (SMARCC1) OTUOMBE7 SMRC1_HUMAN Increases Expression [79]
Receptor-type tyrosine-protein phosphatase N2 (PTPRN2) OTL6SH28 PTPR2_HUMAN Increases Methylation [58]
Lipoma-preferred partner (LPP) OT6TU8SE LPP_HUMAN Increases Methylation [58]
Mediator of RNA polymerase II transcription subunit 12 (MED12) OTQZ4D2X MED12_HUMAN Increases Methylation [58]
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 (ATP2A3) OTFYDEES AT2A3_HUMAN Increases Methylation [58]
Secretory carrier-associated membrane protein 4 (SCAMP4) OTSCZTJ5 SCAM4_HUMAN Increases Methylation [58]
Endoplasmic reticulum-Golgi intermediate compartment protein 1 (ERGIC1) OT351FKB ERGI1_HUMAN Decreases Methylation [58]
Terminal nucleotidyltransferase 5B (TENT5B) OTO2P28B TET5B_HUMAN Increases Methylation [58]
Collagen alpha-1(XXVI) chain (COL26A1) OTMS7RNF COQA1_HUMAN Decreases Methylation [58]
Isochorismatase domain-containing protein 2 (ISOC2) OT69N6MB ISOC2_HUMAN Increases Methylation [58]
Repulsive guidance molecule A (RGMA) OTZAMDO2 RGMA_HUMAN Increases Methylation [58]
Dedicator of cytokinesis protein 10 (DOCK10) OTI3MBLV DOC10_HUMAN Increases Methylation [58]
EF-hand domain-containing protein D2 (EFHD2) OTM9VMN3 EFHD2_HUMAN Increases Methylation [58]
Netrin-G2 (NTNG2) OTTY88DL NTNG2_HUMAN Increases Methylation [58]
Anaphase-promoting complex subunit 16 (ANAPC16) OTG9MUYS APC16_HUMAN Increases Methylation [58]
Rho guanine nucleotide exchange factor 26 (ARHGEF26) OTX0U8PX ARHGQ_HUMAN Increases Methylation [58]
PHD finger protein 21B (PHF21B) OTU5GLCQ PF21B_HUMAN Increases Methylation [58]
Polypeptide N-acetylgalactosaminyltransferase 14 (GALNT14) OT9BSDDQ GLT14_HUMAN Increases Methylation [58]
CKLF-like MARVEL transmembrane domain-containing protein 7 (CMTM7) OTI7Q2JW CKLF7_HUMAN Decreases Methylation [58]
Aurora kinase B (AURKB) OTIY4VHU AURKB_HUMAN Decreases Expression [59]
Protein FAM163A (FAM163A) OT0MYZ0F F163A_HUMAN Increases Methylation [58]
SH3 domain-containing YSC84-like protein 1 (SH3YL1) OTVXOONW SH3Y1_HUMAN Increases Methylation [58]
ATP-binding cassette sub-family C member 11 (ABCC11) OTVHL7OR MRP8_HUMAN Increases Methylation [58]
Cadherin-related family member 1 (CDHR1) OT1ORXCM CDHR1_HUMAN Decreases Methylation [58]
Membrane-spanning 4-domains subfamily A member 4A (MS4A4A) OTWV82RP M4A4A_HUMAN Decreases Methylation [58]
Protein maelstrom homolog (MAEL) OTZ2VU30 MAEL_HUMAN Decreases Methylation [58]
MAP/microtubule affinity-regulating kinase 4 (MARK4) OT6Z2TGV MARK4_HUMAN Increases Methylation [58]
Zeta-sarcoglycan (SGCZ) OTVGTEOD SGCZ_HUMAN Decreases Methylation [58]
Adenylate kinase 8 (AK8) OT2UF6YM KAD8_HUMAN Decreases Methylation [58]
bMERB domain-containing protein 1 (BMERB1) OT1IH086 MERB1_HUMAN Increases Methylation [58]
Junctional sarcoplasmic reticulum protein 1 (JSRP1) OT1AAYWO JSPR1_HUMAN Increases Methylation [58]
Cytosolic carboxypeptidase 4 (AGBL1) OT8NQLH0 CBPC4_HUMAN Decreases Methylation [58]
Nucleolar protein 4-like (NOL4L) OT14W6UW NOL4L_HUMAN Increases Methylation [58]
Retinol dehydrogenase 12 (RDH12) OTELFRRJ RDH12_HUMAN Increases Methylation [58]
N-terminal EF-hand calcium-binding protein 3 (NECAB3) OTRASC9G NECA3_HUMAN Increases Methylation [58]
Noelin-3 (OLFM3) OTBHPDTL NOE3_HUMAN Decreases Methylation [58]
Erythroid membrane-associated protein (ERMAP) OTKXBB52 ERMAP_HUMAN Decreases Methylation [58]
CUB and sushi domain-containing protein 1 (CSMD1) OTIVDSC4 CSMD1_HUMAN Decreases Methylation [58]
PHD finger protein 12 (PHF12) OTECRO7N PHF12_HUMAN Increases Methylation [58]
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (MAGI1) OTMV4ASV MAGI1_HUMAN Decreases Methylation [58]
Olfactory receptor 8B4 (OR8B4) OTT4T35X OR8B4_HUMAN Decreases Methylation [58]
Galactose-3-O-sulfotransferase 4 (GAL3ST4) OTCXGJGO G3ST4_HUMAN Increases Methylation [58]
Erbin (ERBIN) OTNWTUA8 ERBIN_HUMAN Increases Methylation [58]
Intraflagellar transport protein 140 homolog (IFT140) OT6KO5FH IF140_HUMAN Increases Methylation [58]
GPI transamidase component PIG-S (PIGS) OTCC4CEN PIGS_HUMAN Increases Methylation [58]
Tetraspanin-18 (TSPAN18) OTHSGPVB TSN18_HUMAN Decreases Methylation [58]
2-aminoethanethiol dioxygenase (ADO) OTRLGQ7V AEDO_HUMAN Increases Methylation [58]
Eyes absent homolog 1 (EYA1) OTHU807A EYA1_HUMAN Decreases Methylation [58]
G-protein coupled estrogen receptor 1 (GPER1) OTUK0TDC GPER1_HUMAN Increases Expression [93]
Prohibitin-2 (PHB2) OTCAX3AW PHB2_HUMAN Decreases Expression [60]
Ataxin-2 (ATXN2) OT465IGT ATX2_HUMAN Increases Methylation [58]
Tumor susceptibility gene 101 protein (TSG101) OT97UIXC TS101_HUMAN Increases Methylation [58]
Calcium and integrin-binding protein 1 (CIB1) OT4BVCRU CIB1_HUMAN Increases Methylation [58]
Histone H2B type 1-M (H2BC14) OTSDZZZY H2B1M_HUMAN Increases Methylation [58]
Cbp/p300-interacting transactivator 2 (CITED2) OT812TV7 CITE2_HUMAN Increases Expression [60]
Semaphorin-3C (SEMA3C) OTEGUY7F SEM3C_HUMAN Increases Methylation [58]
Testican-3 (SPOCK3) OTYSOOO7 TICN3_HUMAN Decreases Methylation [58]
SH3-containing GRB2-like protein 3-interacting protein 1 (SGIP1) OTQW6R3Z SGIP1_HUMAN Increases Methylation [58]
Uncharacterized protein C7orf50 (C7ORF50) OTDHN459 CG050_HUMAN Increases Methylation [58]
Ferroptosis suppressor protein 1 (AIFM2) OT57XWXO FSP1_HUMAN Increases Methylation [58]
Phagosome assembly factor 1 (PHAF1) OTF7ZOG6 PHAF1_HUMAN Increases Methylation [58]
NEDD4 family-interacting protein 1 (NDFIP1) OTIORSWF NFIP1_HUMAN Increases Methylation [58]
Death-inducer obliterator 1 (DIDO1) OT9PB547 DIDO1_HUMAN Increases Methylation [58]
CDK5 and ABL1 enzyme substrate 2 (CABLES2) OTGD9A2A CABL2_HUMAN Increases Methylation [58]
Tubulin-specific chaperone D (TBCD) OTS4JKNQ TBCD_HUMAN Increases Methylation [58]
E3 ubiquitin-protein ligase TRIM62 (TRIM62) OT15YO6N TRI62_HUMAN Decreases Methylation [58]
PHD finger protein 20 (PHF20) OTCBVH5P PHF20_HUMAN Increases Methylation [58]
Protein TALPID3 (KIAA0586) OTOZRC1U TALD3_HUMAN Increases Methylation [58]
Katanin p60 ATPase-containing subunit A-like 1 (KATNAL1) OTBUZ7KA KATL1_HUMAN Increases Methylation [58]
Chitinase domain-containing protein 1 (CHID1) OT4DIUKC CHID1_HUMAN Decreases Methylation [58]
Brother of CDO (BOC) OTXBCY9W BOC_HUMAN Decreases Methylation [58]
Sal-like protein 3 (SALL3) OTJ2LZKQ SALL3_HUMAN Affects Methylation [58]
Leucine-rich repeat-containing G-protein coupled receptor 4 (LGR4) OTIMWEK5 LGR4_HUMAN Increases Methylation [58]
Hydroxycarboxylic acid receptor 1 (HCAR1) OT5ZSESQ HCAR1_HUMAN Increases Methylation [58]
Caspase recruitment domain-containing protein 11 (CARD11) OTRCTLYC CAR11_HUMAN Increases Methylation [58]
Calcium-binding protein 8 (CALN1) OTN2XE4T CABP8_HUMAN Increases Methylation [58]
R-spondin-3 (RSPO3) OTZK8GDS RSPO3_HUMAN Increases Methylation [58]
Histone deacetylase 8 (HDAC8) OT5L4RYX HDAC8_HUMAN Increases Methylation [58]
Dual specificity protein phosphatase 16 (DUSP16) OTK7S078 DUS16_HUMAN Decreases Methylation [58]
Alpha-(1,6)-fucosyltransferase (FUT8) OTJJCVG1 FUT8_HUMAN Decreases Methylation [58]
Hyccin (HYCC1) OTO65AE3 HYCCI_HUMAN Increases Methylation [58]
Keratin-associated protein 2-1 (KRTAP2-1) OTV1SGF2 KRA21_HUMAN Increases Methylation [58]
F-box-like/WD repeat-containing protein TBL1XR1 (TBL1XR1) OTM3B3OA TBL1R_HUMAN Increases Methylation [58]
Reticulon-4 receptor (RTN4R) OT8J693X RTN4R_HUMAN Increases Methylation [58]
Forkhead box protein P3 (FOXP3) OTA9Z9OC FOXP3_HUMAN Increases Methylation [58]
E3 ubiquitin-protein ligase TRIM4 (TRIM4) OTLKQNKQ TRIM4_HUMAN Increases Methylation [58]
Tripartite motif-containing protein 2 (TRIM2) OT0V1YVC TRIM2_HUMAN Increases Methylation [58]
Cilia- and flagella-associated protein 74 (CFAP74) OTVW2BGR CFA74_HUMAN Increases Methylation [58]
SRC kinase signaling inhibitor 1 (SRCIN1) OTQZNQQ5 SRCN1_HUMAN Decreases Methylation [58]
Eukaryotic translation initiation factor 5A-2 (EIF5A2) OT4SY4KY IF5A2_HUMAN Decreases Methylation [58]
Hyaluronan and proteoglycan link protein 2 (HAPLN2) OT0G3KEQ HPLN2_HUMAN Decreases Methylation [58]
Phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP) OT9AGAIJ LHPP_HUMAN Increases Methylation [58]
Transmembrane protein 168 (TMEM168) OTJKZ6G9 TM168_HUMAN Increases Methylation [58]
B-cell lymphoma/leukemia 11A (BCL11A) OTI6ZBP6 BC11A_HUMAN Increases Methylation [58]
EH domain-containing protein 4 (EHD4) OT7G5JTT EHD4_HUMAN Increases Methylation [58]
Enhancer of polycomb homolog 1 (EPC1) OT3Q25ND EPC1_HUMAN Increases Methylation [58]
Sodium-coupled neutral amino acid symporter 1 (SLC38A1) OTO3VD5E S38A1_HUMAN Increases Methylation [58]
Chordin (CHRD) OTNM60Y1 CHRD_HUMAN Increases Methylation [58]
Cysteine-rich secretory protein LCCL domain-containing 1 (CRISPLD1) OT38HXJP CRLD1_HUMAN Increases Methylation [58]
Polyadenylate-binding protein 3 (PABPC3) OTTR9DPT PABP3_HUMAN Increases Methylation [58]
Tumor protein 63 (TP63) OT0WOOKQ P63_HUMAN Increases Methylation [58]
Thiamin pyrophosphokinase 1 (TPK1) OTCHPUD0 TPK1_HUMAN Increases Methylation [58]
Homeodomain-interacting protein kinase 3 (HIPK3) OT4WYQM2 HIPK3_HUMAN Increases Methylation [58]
Serine/threonine-protein kinase PLK3 (PLK3) OT19CT2Z PLK3_HUMAN Increases Methylation [58]
Alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase (ST6GALNAC4) OTJCJQI7 SIA7D_HUMAN Increases Methylation [58]
PR domain zinc finger protein 13 (PRDM13) OTUNAFQW PRD13_HUMAN Increases Methylation [58]
Dual specificity protein phosphatase 21 (DUSP21) OTZAGY5R DUS21_HUMAN Decreases Methylation [58]
Uncharacterized protein C19orf44 (C19ORF44) OTES5EZZ CS044_HUMAN Increases Methylation [58]
Histone-lysine N-methyltransferase SMYD3 (SMYD3) OT9YR20G SMYD3_HUMAN Affects Methylation [58]
Proton-activated chloride channel (PACC1) OTKBS8CC PACC1_HUMAN Increases Methylation [58]
Tetratricopeptide repeat protein 12 (TTC12) OTDB24YV TTC12_HUMAN Increases Methylation [58]
Probable ATP-dependent RNA helicase DDX31 (DDX31) OTNWY581 DDX31_HUMAN Increases Methylation [58]
Protein argonaute-3 (AGO3) OTNQGROH AGO3_HUMAN Affects Methylation [58]
Akirin-1 (AKIRIN1) OTINWTT9 AKIR1_HUMAN Increases Methylation [58]
Homeobox protein NANOG (NANOG) OTUEY1FM NANOG_HUMAN Increases Expression [94]
Adhesion G protein-coupled receptor L3 (ADGRL3) OT81Q8LY AGRL3_HUMAN Decreases Methylation [58]
Protein ERGIC-53-like (LMAN1L) OT2CSBR3 LMA1L_HUMAN Increases Methylation [58]
Histone-lysine N-methyltransferase PRDM16 (PRDM16) OT0BGA27 PRD16_HUMAN Decreases Methylation [58]
Solute carrier family 38 member 10 (SLC38A10) OTXPUL6S S38AA_HUMAN Increases Methylation [58]
Mucin-5B (MUC5B) OTPW6K5C MUC5B_HUMAN Increases Methylation [58]
Transcription factor HES-4 (HES4) OTCGMQDT HES4_HUMAN Increases Methylation [58]
Helicase MOV-10 (MOV10) OT0KAY9G MOV10_HUMAN Increases Methylation [58]
Synaptotagmin-like protein 2 (SYTL2) OTUIOWKL SYTL2_HUMAN Increases Methylation [58]
E3 ubiquitin-protein ligase MSL2 (MSL2) OTVPQYBG MSL2_HUMAN Increases Methylation [58]
Mineralization regulator ANKH (ANKH) OTCN25R5 ANKH_HUMAN Decreases Methylation [58]
Roundabout homolog 2 (ROBO2) OTFJ9FQW ROBO2_HUMAN Decreases Methylation [58]
Fibrosin-1-like protein (FBRSL1) OT4BPXGG FBSL_HUMAN Increases Methylation [58]
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (PDE11A) OT9X261C PDE11_HUMAN Increases Methylation [58]
LYR motif-containing protein 4 (LYRM4) OTK6JCKL LYRM4_HUMAN Increases Methylation [58]
Regulation of nuclear pre-mRNA domain-containing protein 1B (RPRD1B) OTB41D5K RPR1B_HUMAN Increases Methylation [58]
Gephyrin (GPHN) OTAKK1SV GEPH_HUMAN Increases Methylation [58]
Transcriptional and immune response regulator (TCIM) OTARUXQF TCIM_HUMAN Increases Expression [60]
Matrix-remodeling-associated protein 5 (MXRA5) OTXZBWCU MXRA5_HUMAN Decreases Methylation [58]
CTP synthase 2 (CTPS2) OT2X9YO1 PYRG2_HUMAN Increases Methylation [58]
Bromodomain adjacent to zinc finger domain protein 1A (BAZ1A) OTWHOVZS BAZ1A_HUMAN Increases Methylation [58]
Solute carrier family 2, facilitated glucose transporter member 9 (SLC2A9) OTENU71Z GTR9_HUMAN Increases Methylation [58]
Interleukin-17 receptor B (IL17RB) OT0KDNSF I17RB_HUMAN Decreases Expression [59]
Double-stranded RNA-specific editase B2 (ADARB2) OTDJKS39 RED2_HUMAN Increases Methylation [58]
Protein DEPP1 (DEPP1) OTB36PHJ DEPP1_HUMAN Decreases Expression [76]
E3 ubiquitin-protein ligase RNF146 (RNF146) OTE4CO7E RN146_HUMAN Decreases Methylation [58]
Double-stranded RNA-binding protein Staufen homolog 2 (STAU2) OTORNUIF STAU2_HUMAN Decreases Methylation [58]
tRNA:m(4)X modification enzyme TRM13 homolog (TRMT13) OT2H0MCE TRM13_HUMAN Increases Methylation [58]
F-box only protein 28 (FBXO28) OTKTMVC4 FBX28_HUMAN Decreases Methylation [58]
Transmembrane protein 51 (TMEM51) OTZCW8XJ TMM51_HUMAN Increases Methylation [58]
Solute carrier family 52, riboflavin transporter, member 1 (SLC52A1) OTQ4D276 S52A1_HUMAN Increases Methylation [58]
CUE domain-containing protein 1 (CUEDC1) OTQ7V4FF CUED1_HUMAN Increases Methylation [58]
Membrane progestin receptor gamma (PAQR5) OTGGWXQE PAQR5_HUMAN Increases Methylation [58]
Rho guanine nucleotide exchange factor 38 (ARHGEF38) OTA6K93F ARH38_HUMAN Increases Methylation [58]
Odorant-binding protein 2a (OBP2A) OTBIJ5TI OBP2A_HUMAN Increases Methylation [58]
Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) OTPT2I7B SL2A8_HUMAN Increases Methylation [58]
Sodium channel regulatory subunit beta-3 (SCN3B) OTNTQT9O SCN3B_HUMAN Decreases Methylation [58]
Probable ATP-dependent RNA helicase DDX56 (DDX56) OTGURA53 DDX56_HUMAN Increases Methylation [58]
Cytochrome c oxidase assembly factor 4 homolog, mitochondrial (COA4) OT8319UQ COA4_HUMAN Increases Methylation [58]
24-hydroxycholesterol 7-alpha-hydroxylase (CYP39A1) OTBAJT4I CP39A_HUMAN Increases Methylation [58]
Cadherin EGF LAG seven-pass G-type receptor 1 (CELSR1) OT7PS8O1 CELR1_HUMAN Increases Methylation [58]
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (SMARCAL1) OTTKXLUZ SMAL1_HUMAN Decreases Methylation [58]
Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) OT9G360P IF2B1_HUMAN Increases Methylation [58]
Ral guanine nucleotide dissociation stimulator-like 1 (RGL1) OTY6ZHVA RGL1_HUMAN Increases Methylation [58]
Interleukin-1 receptor accessory protein-like 1 (IL1RAPL1) OTW3T4B2 IRPL1_HUMAN Decreases Methylation [58]
CXXC-type zinc finger protein 1 (CXXC1) OTO10D1N CXXC1_HUMAN Decreases Methylation [58]
Neurotrimin (NTM) OTHF0UQU NTRI_HUMAN Decreases Methylation [58]
Costars family protein ABRACL (ABRACL) OT95T48Q ABRAL_HUMAN Increases Methylation [58]
Coiled-coil domain-containing protein 180 (CCDC180) OT4AL3LW CC180_HUMAN Increases Methylation [58]
Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2 (NYAP2) OT80PO4Q NYAP2_HUMAN Increases Methylation [58]
Rho GTPase-activating protein 20 (ARHGAP20) OTG1STV8 RHG20_HUMAN Increases Methylation [58]
KAT8 regulatory NSL complex subunit 3 (KANSL3) OTWXDTLY KANL3_HUMAN Decreases Methylation [58]
Arginine-glutamic acid dipeptide repeats protein (RERE) OT3G4GBZ RERE_HUMAN Increases Methylation [58]
Sperm microtubule associated protein 2 (SPMAP2) OTLJPJ39 SPMA2_HUMAN Increases Methylation [58]
Protein IMPACT (IMPACT) OTQ923OB IMPCT_HUMAN Increases Methylation [58]
Copine-7 (CPNE7) OTR0FJ8A CPNE7_HUMAN Increases Methylation [58]
Dickkopf-related protein 3 (DKK3) OTDU94EY DKK3_HUMAN Increases Methylation [58]
PTB domain-containing engulfment adapter protein 1 (GULP1) OT1WMVDH GULP1_HUMAN Increases Methylation [58]
Gamma-aminobutyric acid type B receptor subunit 1 (GABBR1) OTU5A52J GABR1_HUMAN Increases Methylation [58]
Alpha-catulin (CTNNAL1) OTESJ6JD CTNL1_HUMAN Increases Methylation [58]
Protein CLN8 (CLN8) OT0D4CB5 CLN8_HUMAN Decreases Methylation [58]
Tripartite motif-containing protein 10 (TRIM10) OTEO4UCZ TRI10_HUMAN Increases Methylation [58]
Death domain-associated protein 6 (DAXX) OTX6O7PL DAXX_HUMAN Increases Methylation [58]
tRNA (FTSJ1) OTNE7W96 TRM7_HUMAN Increases Methylation [58]
Dynein axonemal heavy chain 17 (DNAH17) OT4G6E70 DYH17_HUMAN Increases Methylation [58]
Regulator of G-protein signaling 17 (RGS17) OT5RVUDS RGS17_HUMAN Decreases Methylation [58]
Olfactory receptor 12D3 (OR12D3) OTQ9XNBB O12D3_HUMAN Increases Methylation [58]
Deleted in malignant brain tumors 1 protein (DMBT1) OTVNU9D9 DMBT1_HUMAN Increases Expression [95]
Switch-associated protein 70 (SWAP70) OTPHT2QD SWP70_HUMAN Decreases Methylation [58]
Contactin-associated protein-like 2 (CNTNAP2) OT48T2ZP CNTP2_HUMAN Increases Methylation [58]
Interleukin-17B (IL17B) OTS86H50 IL17B_HUMAN Decreases Methylation [58]
Sodium channel protein type 11 subunit alpha (SCN11A) OTY0HJJZ SCNBA_HUMAN Increases Methylation [58]
Cardiolipin synthase (CRLS1) OT7XNL0K CRLS1_HUMAN Decreases Methylation [58]
Ectonucleotide pyrophosphatase/phosphodiesterase family member 5 (ENPP5) OTY807N5 ENPP5_HUMAN Decreases Methylation [58]
Anaphase-promoting complex subunit 2 (ANAPC2) OTAGLIAO ANC2_HUMAN Increases Methylation [58]
ADP-ribosylation factor-binding protein GGA1 (GGA1) OTSEV0JU GGA1_HUMAN Increases Methylation [58]
Serine/threonine-protein kinase tousled-like 1 (TLK1) OTICTXI8 TLK1_HUMAN Increases Methylation [58]
POU domain, class 2, transcription factor 3 (POU2F3) OTIOOJWD PO2F3_HUMAN Increases Methylation [58]
Mucin-12 (MUC12) OTYDC13T MUC12_HUMAN Increases Methylation [58]
F-box only protein 5 (FBXO5) OTTR957W FBX5_HUMAN Decreases Expression [59]
Histone deacetylase 9 (HDAC9) OTO8O0LF HDAC9_HUMAN Decreases Methylation [58]
Protein argonaute-2 (AGO2) OT4JY32Q AGO2_HUMAN Increases Methylation [58]
Bromodomain and PHD finger-containing protein 3 (BRPF3) OTRNO4PR BRPF3_HUMAN Increases Methylation [58]
DENN domain-containing protein 2A (DENND2A) OT01E1PL DEN2A_HUMAN Increases Methylation [58]
Cell cycle progression protein 1 (CCPG1) OT0IHDKL CCPG1_HUMAN Increases Methylation [58]
Myocardin-related transcription factor B (MRTFB) OT9OXGS9 MRTFB_HUMAN Decreases Methylation [58]
Protein HEG homolog 1 (HEG1) OT3CUXA7 HEG1_HUMAN Increases Methylation [58]
Glutamate receptor ionotropic, delta-1 (GRID1) OTJ3WIKC GRID1_HUMAN Increases Methylation [58]
Transcription factor MafF (MAFF) OT9B7MX0 MAFF_HUMAN Increases Expression [60]
Protein ATP1B4 (ATP1B4) OT2YC9GZ AT1B4_HUMAN Decreases Methylation [58]
Dual specificity protein phosphatase CDC14A (CDC14A) OTL10OY6 CC14A_HUMAN Increases Methylation [58]
FAS-associated factor 1 (FAF1) OTGAMLM4 FAF1_HUMAN Increases Methylation [58]
Protein timeless homolog (TIMELESS) OTD8DCBJ TIM_HUMAN Decreases Expression [59]
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (MACF1) OTVIHD77 MACF1_HUMAN Increases Methylation [58]
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 (AGAP1) OTVX8835 AGAP1_HUMAN Affects Methylation [58]
Trinucleotide repeat-containing gene 6B protein (TNRC6B) OTGVT0SH TNR6B_HUMAN Increases Methylation [58]
Transcription factor 19 (TCF19) OT7NKLF9 TCF19_HUMAN Decreases Expression [59]
Type 2 lactosamine alpha-2,3-sialyltransferase (ST3GAL6) OTB17Q43 SIA10_HUMAN Increases Methylation [58]
UDP-N-acetylglucosamine transporter (SLC35A3) OTG92DK5 S35A3_HUMAN Increases Methylation [58]
Protein strawberry notch homolog 2 (SBNO2) OT1C6J3K SBNO2_HUMAN Increases Methylation [58]
Angiomotin-like protein 2 (AMOTL2) OTRCTKV9 AMOL2_HUMAN Increases Methylation [58]
Serine/threonine-protein kinase SIK3 (SIK3) OTH0V1L5 SIK3_HUMAN Increases Methylation [58]
Peptidyl-prolyl cis-trans isomerase-like 1 (PPIL1) OTS5S837 PPIL1_HUMAN Increases Methylation [58]
Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1) OT8M52QY LMBL1_HUMAN Decreases Methylation [58]
Transformation/transcription domain-associated protein (TRRAP) OT68OI2Y TRRAP_HUMAN Increases Methylation [58]
FERM, ARHGEF and pleckstrin domain-containing protein 1 (FARP1) OTL1EBTM FARP1_HUMAN Increases Methylation [58]
Centrosomal protein of 170 kDa protein B (CEP170B) OTYB0VGH C170B_HUMAN Increases Methylation [58]
Protein PRRC2C (PRRC2C) OTBX3MXM PRC2C_HUMAN Increases Methylation [58]
Ankyrin repeat and SOCS box protein 4 (ASB4) OTI4AFZL ASB4_HUMAN Increases Methylation [58]
Ankyrin repeat and SOCS box protein 3 (ASB3) OTI3TK38 ASB3_HUMAN Decreases Methylation [58]
AP-4 complex subunit sigma-1 (AP4S1) OTM3QBU8 AP4S1_HUMAN Decreases Methylation [58]
Protocadherin gamma-A1 (PCDHGA1) OTR1U1LI PCDG1_HUMAN Increases Methylation [58]
Methyltransferase N6AMT1 (N6AMT1) OTOK0NYQ N6MT1_HUMAN Increases Methylation [58]
Sorting nexin-8 (SNX8) OTMG63Z6 SNX8_HUMAN Increases Methylation [58]
Nuclear receptor corepressor 2 (NCOR2) OTY917X0 NCOR2_HUMAN Increases Methylation [58]
Junctional adhesion molecule A (F11R) OTGHPAV6 JAM1_HUMAN Decreases Methylation [58]
Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (ARFGEF1) OTPAU0L4 BIG1_HUMAN Increases Methylation [58]
Synphilin-1 (SNCAIP) OTH8VNOK SNCAP_HUMAN Increases Methylation [58]
TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L (TAF6L) OTQLO30U TAF6L_HUMAN Increases Methylation [58]
Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) OT4ZSEEE IF2B2_HUMAN Increases Methylation [58]
Nuclear receptor coactivator 3 (NCOA3) OTBX300Z NCOA3_HUMAN Increases Expression [60]
Calmodulin-binding transcription activator 1 (CAMTA1) OTAN1S5B CMTA1_HUMAN Increases Methylation [58]
Ras-related and estrogen-regulated growth inhibitor (RERG) OTF6MMLV RERG_HUMAN Affects Response To Substance [79]
Serine/threonine-protein kinase mTOR (MTOR) OTHH8KU7 MTOR_HUMAN Decreases Response To Substance [59]
Breast cancer anti-estrogen resistance protein 3 (BCAR3) OTPJ17M8 BCAR3_HUMAN Affects Response To Substance [79]
FK506-binding protein-like (FKBPL) OTR9ND6K FKBPL_HUMAN Increases Response To Substance [96]
Anterior gradient protein 2 homolog (AGR2) OTRRZT7W AGR2_HUMAN Affects Response To Substance [97]
AT-rich interactive domain-containing protein 1A (ARID1A) OTRWDV3P ARI1A_HUMAN Decreases Response To Substance [98]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2) OTW8V2V1 ABCG2_HUMAN Affects Response To Substance [79]
Artemin (ARTN) OTWIWGL6 ARTN_HUMAN Decreases Response To Substance [99]
Cyclin-dependent kinase 12 (CDK12) OTZUDGNU CDK12_HUMAN Affects Response To Substance [100]
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⏷ Show the Full List of 985 DOT(s)

Test Results of This Drug Combination in Other Disease Systems

Indication DrugCom ID Cell Line Status REF
Adult T acute lymphoblastic leukemia DCWP914 MOLT-4 Investigative [1]
Anaplastic large cell lymphoma DCDWRYK SR Investigative [1]
Lung adenocarcinoma DCB7IGH EKVX Investigative [1]
Lung adenocarcinoma DCX0AGX NCI-H522 Investigative [1]
------------------------------------------------------------------------------------

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2 Gefitinib FDA Label
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4 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1015).
5 Synergistic antitumor effect of S-1 and the epidermal growth factor receptor inhibitor gefitinib in non-small cell lung cancer cell lines: role of gefitinib-induced down-regulation of thymidylate synthase. Mol Cancer Ther. 2008 Mar;7(3):599-606.
6 Frankincense myrrh attenuates hepatocellular carcinoma by regulating tumor blood vessel development through multiple epidermal growth factor receptor-mediated signaling pathways. World J Gastrointest Oncol. 2022 Feb 15;14(2):450-477. doi: 10.4251/wjgo.v14.i2.450.
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