Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMO36RL)

Drug Name	PMID26560530-Compound-35 Drug Info
Cross-matching ID	PubChem CID 5281847 ChEBI ID CHEBI:8899 CAS Number CAS 82-08-6 TTD Drug ID DMO36RL

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Clinical Trial Drug(s)

Patented Agent(s)

Approved Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Tissue transglutaminase (TG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ZED1227	DMDXEN5	Coeliac disease	DA95	Phase 2	[7]
PMID26560530-Compound-13	DMKF26Z	N. A.	N. A.	Patented	[1]
PMID26560530-Compound-54	DM2X4R0	N. A.	N. A.	Patented	[1]
Triazole derivative 1	DM9QB2S	N. A.	N. A.	Patented	[1]
Acyl piperidine derivative 3	DMIDUB4	N. A.	N. A.	Patented	[1]
PMID26560530-Compound-14	DM52MIK	N. A.	N. A.	Patented	[1]
PMID26560530-Compound-1	DMSI7F2	N. A.	N. A.	Patented	[1]
PMID26560530-Compound-3	DM92OT0	N. A.	N. A.	Patented	[1]
PMID26560530-Compound-11	DMZ5UST	N. A.	N. A.	Patented	[1]
Chloroacetyl ester derivative 1	DMW4J0P	N. A.	N. A.	Patented	[1]
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Drug(s) Affected By MAP kinase-activated protein kinase 2 (MAPKAPK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[8]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[10]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[11]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[12]
Sorbitol	DMAN0DE	Constipation	DD91.1	Approved	[8]
Bortezomib	DMNO38U	Leukemia		Approved	[13]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[14]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[15]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[16]
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Drug(s) Affected By MAP kinase-activated protein kinase 5 (MAPKAPK5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[19]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[20]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[20]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[21]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[22]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[23]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[24]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[25]
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Drug(s) Affected By Aromatase (CYP19A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[26]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[27]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[28]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[29]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[28]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[30]
FADROZOLE	DM3C5GZ	Breast cancer	2C60-2C65	Approved	[31]
Bifonazole	DM3KN7V	Fungal infection	1F29-1F2F	Approved	[32]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[28]
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Drug(s) Affected By Ubiquitin-like modifier-activating enzyme ATG7 (ATG7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[34]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[35]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[38]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[39]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[40]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[42]
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Drug(s) Affected By Claudin-1 (CLDN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[43]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[44]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[45]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[47]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[48]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[49]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[50]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[51]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[52]
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Drug(s) Affected By RAF proto-oncogene serine/threonine-protein kinase (RAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[53]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[54]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[55]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[12]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[57]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[58]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[59]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[60]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[61]
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Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[62]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[63]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[64]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[65]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[66]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[67]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[68]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[69]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[70]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[62]
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Drug(s) Affected By Retinoblastoma-associated protein (RB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[71]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[72]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[73]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[74]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[75]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[76]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[77]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[78]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[79]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
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Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[64]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[81]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[82]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[83]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[84]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[85]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[84]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[86]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[87]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[88]
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Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[89]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[90]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[91]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[65]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[92]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[67]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[93]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[94]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[95]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[93]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[96]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[99]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[100]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[64]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[101]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[102]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[103]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[104]
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Drug(s) Affected By Endoplasmic reticulum chaperone BiP (HSPA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[105]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[106]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[107]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[108]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[109]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[110]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[111]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[112]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[113]
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Drug(s) Affected By Macrophage migration inhibitory factor (MIF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[114]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[115]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[10]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[116]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[117]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[118]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[119]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[120]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[14]
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Drug(s) Affected By Neurotensin/neuromedin N (NTS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[121]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[49]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[122]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[123]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[124]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[125]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[20]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[126]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[122]
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Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[127]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[128]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[129]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[104]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[130]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[131]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[132]
Selenium	DM25CGV	N. A.	N. A.	Approved	[133]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[134]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[135]
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Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[136]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[137]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[138]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[139]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[106]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[140]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[109]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[141]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[142]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
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Drug(s) Affected By Serine/threonine-protein kinase mTOR (MTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[143]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[144]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[145]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[34]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[146]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[135]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[147]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[149]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[150]
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Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[151]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[152]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[153]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[154]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[155]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[156]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[157]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[158]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[159]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[160]
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Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[161]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[162]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[64]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[102]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[163]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[164]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[83]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[165]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[166]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[167]
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Drug(s) Affected By Hepcidin (HAMP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[168]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[70]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[169]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[52]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[170]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[171]
Papaverine	DMCA9QP	Brain ischaemia	8B1Z	Approved	[171]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[172]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[173]
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Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 1 (MAP2K1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[53]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[175]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[176]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[177]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[57]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[60]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[178]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[117]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[179]
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Drug(s) Affected By Protein kinase C theta type (PRKCQ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[180]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[170]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[181]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[182]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[120]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[183]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[184]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[185]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[186]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[185]
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Drug(s) Affected By Tight junction protein ZO-1 (TJP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[43]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[75]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[45]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[187]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[117]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[188]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[189]
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Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[96]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[160]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[64]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[101]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[190]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[163]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[74]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[75]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[191]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[85]
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Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[129]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[192]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[83]
Selenium	DM25CGV	N. A.	N. A.	Approved	[133]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[193]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[45]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[194]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[195]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[196]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[197]
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Drug(s) Affected By Beclin-1 (BECN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[198]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[64]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[146]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[45]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[199]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[200]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[201]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[202]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[203]
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Drug(s) Affected By Mitogen-activated protein kinase 14 (MAPK14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[204]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[205]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[206]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[207]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[208]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[209]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[176]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[210]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[211]
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Drug(s) Affected By Occludin (OCLN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[212]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[213]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[5]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[214]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[215]
Thioguanine	DM7NKEV	Acute lymphocytic leukaemia	2B33.3	Approved	[216]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[217]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[181]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[188]
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Drug(s) Affected By Growth/differentiation factor 15 (GDF15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[136]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[140]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[218]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[219]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[180]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[220]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[221]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[222]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[223]
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Drug(s) Affected By Protein kinase C delta type (PRKCD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[224]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[225]
Butorphanol	DM5KYPJ	Pain	MG30-MG3Z	Approved	[226]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[227]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[228]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[229]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[187]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[215]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[230]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Tissue transglutaminase (TG2)	TT2F4OL	TGM2_HUMAN	Inhibitor	[1]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Gene/Protein Processing	[2]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[2]
Aromatase (CYP19A1)	OTZ6XF74	CP19A_HUMAN	Gene/Protein Processing	[3]
Bcl-2-like protein 1 (BCL2L1)	OTRC5K9O	B2CL1_HUMAN	Gene/Protein Processing	[2]
Beclin-1 (BECN1)	OT4X293M	BECN1_HUMAN	Gene/Protein Processing	[2]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Gene/Protein Processing	[4]
Caspase-9 (CASP9)	OTD4RFFG	CASP9_HUMAN	Protein Interaction/Cellular Processes	[2]
Claudin-1 (CLDN1)	OT27KV99	CLD1_HUMAN	Protein Interaction/Cellular Processes	[5]
DNA damage-inducible transcript 3 protein (DDIT3)	OTI8YKKE	DDIT3_HUMAN	Gene/Protein Processing	[4]
Dual specificity mitogen-activated protein kinase kinase 1 (MAP2K1)	OT4Y9NQI	MP2K1_HUMAN	Post-Translational Modifications	[6]

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