General Information of Drug (ID: DMQJXL4)

Drug Name
AMG 386 Drug Info
Synonyms
7440-23-5; Natrium; Sodium-23; Sodio; Sodium metal; Sodio [Spanish]; Sodium (liquid alloy); UNII-9NEZ333N27; HSDB 687; EINECS 231-132-9; UN1428; UNII-23J3BHR95O; Sodium, dry stick; 9NEZ333N27; MFCD00085307; Sodium, 998%, oiled sticks, wrapped in aluminium foil; monosodium; sodium atom; mono sodium; mono-sodium; Sodium, CP; SodiuR4733m hydride, CP; AC1NSENP; ACMC-1BKTZ; Sodium, ACS reagent, dry; 11Na; EC 231-132-9; AC1Q1W6R; SODIUM, LARGE PIECES; Sodium hydride, dry, 95%; NAH 80; HSDB 745; CTK2H7876; CHEBI:26708; Oravescent fentanyl; R3487; PT-15; R4930
Indication
Disease Entry ICD 11 Status REF
Breast cancer 2C60-2C65 Phase 3 [1]
Neuropathic pain 8E43.0 Phase 3 [2]
Alzheimer disease 8A20 Phase 2 [3]
Asthma CA23 Discontinued in Phase 2 [4]
Sexual dysfunction HA00-HA01 Preclinical [5]
Cross-matching ID
PubChem CID
5360545
ChEBI ID
CHEBI:26708
CAS Number
CAS 7440-23-5
TTD Drug ID
DMQJXL4

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Preclinical Drug(s)
Investigative Drug(s)
Patented Agent(s)
Drug(s) Targeting Angiopoietin-2 (ANGPT2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Faricimab DM83SEB Diabetic macular edema 9B71.02 Approved [19]
Trebananib DMOG2X1 Ovarian cancer 2C73 Phase 3 [20]
RG7221 DM8J9DC Colorectal cancer 2B91.Z Phase 2 [21]
RO5520985 DMD3WNP Colorectal cancer 2B91.Z Phase 2 [22]
LY3127804 DMAC457 Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 2 Trial [23]
REGN910-3 DMTBRPO Neovascular age-related macular degeneration 9B78.3Z Phase 2 [24]
CVX-060 DM03LWZ Solid tumour/cancer 2A00-2F9Z Phase 1/2 [25]
BI 836880 DMRI6YT Neoplasm 2A00-2F9Z Phase 1 [26]
CVX-241 DMV74JC Solid tumour/cancer 2A00-2F9Z Phase 1 [27]
REGN-910 DMHR7D4 Solid tumour/cancer 2A00-2F9Z Phase 1 [28]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Opioid receptor (OPR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methadone DMTW6IU Advanced cancer 2A00-2F9Z Approved [29]
Ketobemidone DMM3L6Z Pain MG30-MG3Z Approved [30]
Oxymorphone DM65AGJ Pain MG30-MG3Z Approved [31]
Dextropropoxyphene DM23HCX Pain MG30-MG3Z Approved [32]
Sufentanil DMU7YEL Analgesia MB40.8 Approved [33]
Naltrexone DMUL45H Alcohol dependence 6C40.2 Approved [34]
Levorphanol DMGS80V Pain MG30-MG3Z Approved [35]
Pentazocine DM1XBHS Pain MG30-MG3Z Approved [36]
Nalmefene DM4YWCZ Opioid dependence 6C43.2Z Approved [37]
Tilidine DMJW0VS Pain MG30-MG3Z Approved [38]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Ziprasidone DMM58JY Bipolar disorder 6A60 Approved [39]
ALCURONIUM DM2U4XQ Anaesthesia 9A78.6 Approved [40]
CYTISINE DMUF0BJ Tobacco dependence 6C4A.2 Phase 3 [41]
EVP-6124 DMLQO7F Alzheimer disease 8A20 Phase 3 [42]
GTS-21 DMEN5KA Parkinson disease 8A00.0 Phase 2 [43]
JNJ-39393406 DMUOEKM Depression 6A70-6A7Z Phase 2 [44]
ABT-126 DM2OS51 Alzheimer disease 8A20 Phase 2 [45]
TC-6987 DMNFP21 Asthma CA23 Phase 2 [46]
AQW-051 DMD2RFO Alzheimer disease 8A20 Phase 2 [47]
MEM-3454 DMPNDYU Schizophrenia 6A20 Phase 2 [39]
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Drug(s) Targeting Angiopoietin-1 (ANGPT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Trebananib DMOG2X1 Ovarian cancer 2C73 Phase 3 [20]
AMG 780 DMTGZN8 Solid tumour/cancer 2A00-2F9Z Phase 1 [48]
Drug Name Drug ID Indication ICD 11 Highest Status REF
RG7888 DM2SWI8 Solid tumour/cancer 2A00-2F9Z Phase 2 [49]
Amlitelimab DMKR3BQ Asthma CA23 Phase 2 [50]
mRNA-2752 DMUKBI2 Solid tumour/cancer 2A00-2F9Z Phase 1 [51]
MEDI6383 DM1YSMD Solid tumour/cancer 2A00-2F9Z Phase 1 [52]
mRNA-2416 DMFTAWU Lymphoma 2A80-2A86 Phase 1 [53]
SAR442970 DM3DHWE Inflammation 1A00-CA43.1 Phase 1 [54]
⏷ Show the Full List of 6 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methylnaltrexone bromide DMZTGN2 Opioid-induced constipation DB32.1 Approved [5]
Bremelanotide DM20LIM Hypoactive sexual desire dysfunction HA00 Approved [55]
Setmelanotide DMPVRN9 Obesity 5B81 Approved [56]
Amylin DMWDEN0 N. A. N. A. Phase 4 [57]
PMX-53 DMZUAJ4 Atopic dermatitis EA80 Phase 2 [58]
PF-446687 DML38VU Female sexual arousal dysfunction HA01.1 Phase 2 [59]
AP-1030 DMBGA35 Metabolic disorder 5C50-5D2Z Phase 1/2 [6]
PF-07258669 DM3CJ5N Malnutrition 5B50-5B71 Phase 1 [60]
PT-14 DMYM9JL Erectile dysfunction HA01.1 Discontinued in Phase 2 [61]
Melanotetan II DMYK8MV Obesity 5B81 Preclinical [5]
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Drug(s) Targeting Gamma-secretase (GS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nirogacestat DMUP5Z0 Desmoid tumour 2F7C Approved [62]
(S)-FLURBIPROFEN DMF2O4T Myalgia FB56.2 Preregistration [63]
Semagacestat DML83IW Parkinson disease 8A00.0 Phase 3 [64]
R-flurbiprofen DMFIVSR N. A. N. A. Phase 2 [63]
MK-0752 DMLTAES Alzheimer disease 8A20 Phase 2 [65]
BMS-708163 DM51LTG Alzheimer disease 8A20 Phase 2 [66]
CHF-5074 DMTE071 Alzheimer disease 8A20 Phase 2 [67]
RO-4929097 DMXA6B3 Breast cancer 2C60-2C65 Phase 2 [68]
AL102 DMCTWIB Desmoid tumour 2F7C Phase 2 [69]
SPI-014 DM5IPUS Alzheimer disease 8A20 Phase 1 [70]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ceruloplasmin (CP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [71]
Quercetin DM3NC4M Obesity 5B81 Approved [72]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [73]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [74]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [75]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [76]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [79]
Ampicillin DMHWE7P Acute epiglottitis Approved [72]
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Drug(s) Affected By Renin (REN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [80]
Acebutolol DM0TI4U Hypertension BA00-BA04 Approved [81]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [82]
Reboxetine DM26PRD Depression 6A70-6A7Z Approved [83]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [84]
Ramipril DM2R68E Acute heart failure BD10-BD13 Approved [85]
Rhucin DM3ADGP Erectile dysfunction HA01.1 Approved [86]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [87]
Epinephrine DM3KJBC Acute asthma CA23 Approved [88]
Chlorthalidone DM4DMBT Edema MG29 Approved [89]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Kallikrein-1 (KLK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [90]
Magnesium DMU4ORS Ischemic stroke 8B11.5Z Approved [15]
Dobutamine DMD1B8Z Heart failure BD10-BD13 Approved [91]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [92]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [93]
acetaldehyde DMJFKG4 Discovery agent N.A. Investigative [94]
⏷ Show the Full List of 6 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [95]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [96]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [97]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [98]
Adefovir DMM278X N. A. N. A. Approved [99]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [100]
CHLORIDE DM1TJXA Solid tumour/cancer 2A00-2F9Z Phase 3 [101]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [93]
D-glucose DMMG2TO Discovery agent N.A. Investigative [102]
Selenious acid DMB7GPA N. A. N. A. Investigative [103]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [104]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [105]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [106]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [107]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [74]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [108]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [109]
Paclitaxel DMLB81S Breast carcinoma Approved [110]
Arsenic DMTL2Y1 N. A. N. A. Approved [111]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sodium bicarbonate DMMU6BJ Metabolic acidosis 5C73 Approved [13]
Selenium DM25CGV N. A. N. A. Approved [112]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [73]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [113]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [114]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [115]
Arsenic DMTL2Y1 N. A. N. A. Approved [116]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [117]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [118]
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Drug(s) Affected By Somatotropin (GH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Polyethylene glycol DM4I1JP Constipation DD91.1 Approved [119]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [120]
Adenosine triphosphate DM79F6G Malnutrition 5B50-5B71 Approved [121]
Cyproheptadine DM92AH3 Allergic rhinitis CA08.0 Approved [122]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [96]
Sodium oxybate DMBOV5P Narcolepsy 7A20 Approved [123]
Ethanol DMDRQZU Chronic pain MG30 Approved [119]
Connexyn DMF29Q5 Attention deficit hyperactivity disorder 6A05.Z Approved [124]
Gamma Hydroxybutyric Acid DMGBKVD Narcolepsy 7A20 Approved [125]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [126]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [127]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [128]
Prednisone DM2HG4X Acute asthma CA23 Approved [129]
Triamterene DM2HU9I Congestive heart failure BD10 Approved [129]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [130]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [131]
Epinephrine DM3KJBC Acute asthma CA23 Approved [132]
Quercetin DM3NC4M Obesity 5B81 Approved [104]
Fluoxetine DM3PD2C Bipolar depression Approved [133]
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [134]
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Drug(s) Affected By Angiotensinogen (AGT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [135]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [136]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [137]
Reboxetine DM26PRD Depression 6A70-6A7Z Approved [83]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [138]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [139]
Rhucin DM3ADGP Erectile dysfunction HA01.1 Approved [86]
Quercetin DM3NC4M Obesity 5B81 Approved [72]
Lisinopril DMUOK4C Chronic heart failure BD1Z Approved [140]
Irbesartan DMTP1DC Diabetic kidney disease GB61.Z Approved [141]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Uridine DMQTREB Depression 6A70-6A7Z Approved [142]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [109]
Arsenic DMTL2Y1 N. A. N. A. Approved [111]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [143]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [144]
Adenosine DMM2NSK Paroxysmal supraventricular tachycardia BC81.Z Approved [142]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [145]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [146]
Purine Riboside DMHNS0V Discovery agent N.A. Investigative [142]
⏷ Show the Full List of 9 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [147]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [96]
Menthol DMG2KW7 Back pain ME84.Z Approved [148]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [149]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [145]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [93]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [150]
⏷ Show the Full List of 7 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aldosterone DM9S2JW Hypertension BA00-BA04 Approved [151]
FADROZOLE DM3C5GZ Breast cancer 2C60-2C65 Approved [152]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [153]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [96]
Potassium Chloride DMMTAJC Hypokalemia 5C77 Approved [154]
Dutasteride DMQ4TJK Benign prostatic hyperplasia GA90 Approved [155]
Mitotane DMU1GX0 Adrenocortical carcinoma 2D11.Z Approved [156]
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [153]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [157]
Irbesartan DMTP1DC Diabetic kidney disease GB61.Z Approved [158]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [159]
Selenium DM25CGV N. A. N. A. Approved [160]
Methotrexate DM2TEOL Anterior urethra cancer Approved [161]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [162]
Epinephrine DM3KJBC Acute asthma CA23 Approved [163]
Quercetin DM3NC4M Obesity 5B81 Approved [164]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [165]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [166]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [167]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [168]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [169]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [106]
Leflunomide DMR8ONJ Arthritis FA20 Approved [170]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [171]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [172]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [93]
Arachidonic Acid DMUOQZD Discovery agent N.A. Investigative [173]
⏷ Show the Full List of 7 Drug(s)
Drug(s) Affected By Secretin (SCT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [174]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [175]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [96]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [97]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [176]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [172]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [177]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [178]
Pentagastrin DMRCLZB Diagnostic imaging N.A. Approved [179]
CHLORIDE DM1TJXA Solid tumour/cancer 2A00-2F9Z Phase 3 [17]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [106]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [180]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [181]
Arsenic DMTL2Y1 N. A. N. A. Approved [111]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [172]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [93]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [182]
Milchsaure DM462BT Pruritus EC90 Investigative [183]
benzamil DM57SVW Discovery agent N.A. Investigative [181]
3-iodothyronamine DM3L0F8 Discovery agent N.A. Investigative [184]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Angiopoietin-1 (ANGPT1) TTWNQ1T ANGP1_HUMAN Modulator [6]
Angiopoietin-2 (ANGPT2) TTKLQTJ ANGP2_HUMAN Modulator [6]
Gamma-secretase (GS) TT9W8GU APH1A_HUMAN; APH1B_HUMAN; PEN2_HUMAN; NICA_HUMAN; PSN1_HUMAN Inhibitor [7]
Melanocortin receptor 4 (MC4R) TTD0CIQ MC4R_HUMAN Agonist [5]
Neuronal acetylcholine receptor alpha-7 (CHRNA7) TTLA931 ACHA7_HUMAN Agonist [7]
Opioid receptor (OPR) TTN4QDT NOUNIPROTAC Agonist [2]
TAX transcriptionally-activated glycoprotein 1 (OX40) TTBW580 TNFL4_HUMAN Modulator [8]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Angiotensinogen (AGT) OTBZLYR3 ANGT_HUMAN Regulation of Drug Effects [9]
Band 3 anion transport protein (SLC4A1) OT3EFUK8 B3AT_HUMAN Regulation of Drug Effects [10]
Ceruloplasmin (CP) OTM8JE4Y CERU_HUMAN Protein Interaction/Cellular Processes [11]
Cytochrome P450 11B2, mitochondrial (CYP11B2) OTIOLWYN C11B2_HUMAN Drug Response [12]
Electrogenic sodium bicarbonate cotransporter 1 (SLC4A4) OT727K92 S4A4_HUMAN Regulation of Drug Effects [13]
Hypoxia-inducible factor 1-alpha (HIF1A) OTADSC03 HIF1A_HUMAN Regulation of Drug Effects [14]
Kallikrein-1 (KLK1) OTFGP3UR KLK1_HUMAN Gene/Protein Processing [15]
Renin (REN) OT52GZR2 RENI_HUMAN Gene/Protein Processing [16]
Secretin (SCT) OTV3MLOO SECR_HUMAN Regulation of Drug Effects [17]
Sodium/hydrogen exchanger 1 (SLC9A1) OT6HNHFV SL9A1_HUMAN Regulation of Drug Effects [18]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8414).
2 Emerging drugs in neuropathic pain. Expert Opin Emerg Drugs. 2007 Mar;12(1):113-26.
3 Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system. Nat Rev Drug Discov. 2009 Sep;8(9):733-50.
4 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027884)
5 Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60.
6 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
7 Clinical pipeline report, company report or official report of Roche (2009).
8 Clinical targeting of the TNF and TNFR superfamilies.Nat Rev Drug Discov.2013 Feb;12(2):147-68.
9 Effects of truncated angiotensins in humans after double blockade of the renin system. Am J Physiol Regul Integr Comp Physiol. 2003 Nov;285(5):R981-91. doi: 10.1152/ajpregu.00263.2003. Epub 2003 Jul 17.
10 Monovalent cation leaks in human red cells caused by single amino-acid substitutions in the transport domain of the band 3 chloride-bicarbonate exchanger, AE1. Nat Genet. 2005 Nov;37(11):1258-63. doi: 10.1038/ng1656. Epub 2005 Oct 9.
11 Ceruloplasmin revisited: structural and functional roles of various metal cation-binding sites. Acta Crystallogr D Biol Crystallogr. 2007 Feb;63(Pt 2):240-8. doi: 10.1107/S090744490604947X. Epub 2007 Jan 16.
12 Renin-angiotensin-aldosterone system and G-protein beta-3 subunit gene polymorphisms in salt-sensitive essential hypertension. J Hum Hypertens. 2003 Mar;17(3):187-91. doi: 10.1038/sj.jhh.1001534.
13 G418-mediated ribosomal read-through of a nonsense mutation causing autosomal recessive proximal renal tubular acidosis. Am J Physiol Renal Physiol. 2008 Sep;295(3):F633-41. doi: 10.1152/ajprenal.00015.2008. Epub 2008 Jul 9.
14 Overexpression of HIF-1 transgene in the renal medulla attenuated salt sensitive hypertension in Dahl S rats. Biochim Biophys Acta. 2012 Jun;1822(6):936-41. doi: 10.1016/j.bbadis.2012.02.002. Epub 2012 Feb 12.
15 The effect of cations on the amidase activity of human tissue kallikrein: 1-linear competitive inhibition by sodium, potassium, calcium and magnesium. 2-linear mixed inhibition by aluminium. J Enzyme Inhib Med Chem. 2004 Aug;19(4):317-25. doi: 10.1080/14756360409162444.
16 Endothelial function during stimulation of renin-angiotensin system by low-sodium diet in humans. Am J Physiol Heart Circ Physiol. 2001 May;280(5):H2248-54. doi: 10.1152/ajpheart.2001.280.5.H2248.
17 The influence of secretin on ion transport in the human jejunum. Gut. 1973 Jun;14(6):485-90. doi: 10.1136/gut.14.6.485.
18 Mutations of Arg440 and Gly455/Gly456 oppositely change pH sensing of Na+/H+ exchanger 1. J Biol Chem. 2003 Apr 4;278(14):11828-35. doi: 10.1074/jbc.M213243200. Epub 2003 Jan 30.
19 Faricimab: an investigational agent targeting the Tie-2/angiopoietin pathway and VEGF-A for the treatment of retinal diseases. Expert Opin Investig Drugs. 2021 Mar;30(3):193-200.
20 Pediatric Phase I Trial and Pharmacokinetic Study of Trebananib in Relapsed Solid Tumors, Including Primary Tumors of the Central Nervous System ADVL1115: A Children's Oncology Group Phase I Consortium Report. Clin Cancer Res. 2017 Oct 15;23(20):6062-6069.
21 Company report (Roche pipeline: July 27, 2017)
22 Bispecific antibodies rise again. Nat Rev Drug Discov. 2014 Nov;13(11):799-801.
23 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
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