Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMU7FC5)

Drug Name
[3H]CP55940 Drug Info
Synonyms
5-(1,1-Dimethylheptyl)-2-[5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]phenol; CP55940; CP-55940; UNII-KFY70972J5; CP55,940; CP 55940; CP 55,940; KFY70972J5; 2-[(1r,2r,5r)-5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]-5-(2-methyloctan-2-yl)phenol; 83002-04-4; CP-55,940; 83003-12-7; C24H40O3; 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol; Phenol, 5-(1,1-dimethylheptyl)-2-((1R,2R,5R)-5-hydroxy-2-(3-hydroxypropyl)cyclohexyl)-, rel-
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
104895
CAS Number
CAS 83002-04-4
TTD Drug ID
DMU7FC5

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Cannabinoid receptor 2 (CB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Guanfacine extended release DMB1CZ8 Attention deficit hyperactivity disorder 6A05.Z Approved [10]
NABILONE DMVRYT2 Insomnia 7A00-7A0Z Approved [11]
GW-42004 DMY3KSU Lipid metabolism disorder 5C52.Z Phase 2 [12]
KHK-6188 DMF6CTI Neuropathic pain 8E43.0 Phase 2 [13]
LY-2828360 DMO8IEZ Pain MG30-MG3Z Phase 2 [13]
APD371 DM3XT5V Crohn disease DD70 Phase 2 [14]
S-777469 DMZGNOJ Atopic dermatitis EA80 Phase 2 [15]
842166X DMOV0AP Pain MG30-MG3Z Phase 2 [16]
Beta-caryophyllene DM7583A Pain MG30-MG3Z Phase 2 [17]
Vicasinabin DMF16CU Diabetic retinopathy 9B71.0 Phase 2 [18]
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Drug(s) Targeting Cannabinoid receptor 1 (CB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [19]
NABILONE DMVRYT2 Insomnia 7A00-7A0Z Approved [11]
Orlistat DMRJSP8 Obesity 5B81 Approved [20]
SR141716A DMCO5JZ Obesity 5B81 Approved [21]
Tebipenem DMVSX6O Urinary tract infection GC08 Phase 3 [22]
Conatumumab DM2UOSN Colorectal cancer 2B91.Z Phase 2 [23]
GW-42004 DMY3KSU Lipid metabolism disorder 5C52.Z Phase 2 [12]
SR-147778 DMNAECP Obesity 5B81 Phase 2 [24]
Nimacimab DM21Z68 Diabetic nephropathy GB61.Z Phase 2 [25]
AEF0117 DMQ1GH4 Marijuana use disorder 6C41 Phase 2 [26]
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Drug(s) Targeting G-protein coupled receptor 55 (GPR55)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Guanfacine extended release DMB1CZ8 Attention deficit hyperactivity disorder 6A05.Z Approved [4]
BIO-017 DMYHK3Y Angelman syndrome LD90.0 Phase 1 [27]
N-oleoylethanolamide DMJQ4L7 Discovery agent N.A. Investigative [4]
lysophosphatidylinositol DMETM3R Discovery agent N.A. Investigative [28]
O-1602 DM9VISB Discovery agent N.A. Investigative [29]
abnormal cannabidiol DMV6DAO Discovery agent N.A. Investigative [4]
O-arachidonoyl ethanolamine DML0P72 Discovery agent N.A. Investigative [4]
CID1172084 DMK6YOP Discovery agent N.A. Investigative [30]
CID16020046 DMLWZRT Discovery agent N.A. Investigative [31]
2-arachidonyl glyceryl ether DM2H8TV Discovery agent N.A. Investigative [4]
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Drug(s) Affected By E3 ubiquitin-protein ligase parkin (PRKN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Emtricitabine DMBMUWZ Hepatitis virus infection 1E50-1E51 Approved [32]
Tubocurarine DMBZIVP Anaesthesia 9A78.6 Approved [33]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Ethanol DMDRQZU Chronic pain MG30 Approved [35]
Trifluoperazine DMKBYWI Anxiety Approved [36]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [37]
Methamphetamine DMPM4SK Anxiety Approved [38]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [39]
Arsenic DMTL2Y1 N. A. N. A. Approved [40]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [41]
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Drug(s) Affected By Tumor necrosis factor (TNF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [42]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [43]
Fructose DM43AN2 Vomiting MD90 Approved [44]
Ketoprofen DMRKXPT Bursitis Approved [44]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [45]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [46]
Baclofen DM0QV1J Multiple sclerosis 8A40 Approved [47]
Gefitinib DM15F0X Colon adenocarcinoma Approved [48]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [49]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [50]
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Drug(s) Affected By Cellular tumor antigen p53 (TP53)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [51]
Methotrexate DM2TEOL Anterior urethra cancer Approved [52]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [53]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [54]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [55]
Paclitaxel DMLB81S Breast carcinoma Approved [56]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [57]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [58]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [59]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [60]
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Drug(s) Affected By Transcription factor Jun (JUN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [61]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [62]
Fructose DM43AN2 Vomiting MD90 Approved [44]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [63]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [64]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [65]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [66]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [67]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [68]
Methotrexate DM2TEOL Anterior urethra cancer Approved [69]
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Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [70]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [71]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [72]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [73]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [64]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [74]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [75]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [76]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [77]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [75]
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Drug(s) Affected By Proto-oncogene tyrosine-protein kinase Src (SRC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Bosutinib DMTI8YE Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [78]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [79]
Methotrexate DM2TEOL Anterior urethra cancer Approved [52]
Quercetin DM3NC4M Obesity 5B81 Approved [80]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [81]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [82]
Plicamycin DM7C8YV Hypercalcaemia 5B91.0 Approved [83]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [84]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [84]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
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Drug(s) Affected By C-C motif chemokine 2 (CCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [85]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [86]
Gefitinib DM15F0X Colon adenocarcinoma Approved [87]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [50]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [88]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [89]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [90]
Methotrexate DM2TEOL Anterior urethra cancer Approved [52]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [91]
Quercetin DM3NC4M Obesity 5B81 Approved [92]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [93]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [94]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [95]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [46]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [96]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [97]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [98]
Gefitinib DM15F0X Colon adenocarcinoma Approved [99]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [100]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [101]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [102]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [94]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [103]
Paclitaxel DMLB81S Breast carcinoma Approved [104]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [105]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [93]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [44]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [106]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [46]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [96]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [107]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [108]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [109]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [55]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [110]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [111]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [112]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [113]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [114]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [115]
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Drug(s) Affected By Caspase-9 (CASP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [116]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [117]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [118]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [119]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [120]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [121]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [122]
Meloxicam DM2AR7L Arthritis FA20 Approved [123]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [124]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [125]
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Drug(s) Affected By Interleukin-2 (IL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sirolimus DMGW1ID Advanced cancer 2A00-2F9Z Approved [44]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [88]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [126]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [127]
Methotrexate DM2TEOL Anterior urethra cancer Approved [128]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [129]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [130]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [131]
Fentanyl DM8WAHT Analgesia MB40.8 Approved [132]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [133]
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Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [134]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [115]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [118]
Verapamil DMA7PEW Angina pectoris BA40 Approved [135]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [136]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [120]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [137]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [138]
Meloxicam DM2AR7L Arthritis FA20 Approved [139]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [140]
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Drug(s) Affected By Bcl-2-binding component 3, isoforms 3/4 (BBC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [141]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [122]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [142]
Methotrexate DM2TEOL Anterior urethra cancer Approved [143]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [144]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [145]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [146]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [147]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [148]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [149]
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Drug(s) Affected By Parkinson disease protein 7 (PARK7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [150]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [151]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [152]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [153]
Menthol DMG2KW7 Back pain ME84.Z Approved [154]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [155]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [156]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [157]
Sodium phenylbutyrate DMXLBCQ Spinal muscular atrophy 8B61 Approved [158]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [159]
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Drug(s) Affected By Serine/threonine-protein kinase PINK1, mitochondrial (PINK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [160]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [161]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [162]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [161]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [163]
Ethanol DMDRQZU Chronic pain MG30 Approved [35]
Capsaicin DMGMF6V Back pain ME84.Z Approved [164]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [165]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [166]
Melatonin DMKWFBT Depression 6A70-6A7Z Approved [167]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Cannabinoid receptor 1 (CB1) TT6OEDT CNR1_HUMAN Agonist [2]
Cannabinoid receptor 2 (CB2) TTMSFAW CNR2_HUMAN Agonist [3]
G-protein coupled receptor 55 (GPR55) TTNET8J GPR55_HUMAN Agonist [4]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [5]
Bcl-2-binding component 3, isoforms 3/4 (BBC3) OTUAXDAY BBC3B_HUMAN Gene/Protein Processing [5]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Gene/Protein Processing [6]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [7]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Gene/Protein Processing [7]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Gene/Protein Processing [5]
E3 ubiquitin-protein ligase parkin (PRKN) OTJBN41W PRKN_HUMAN Gene/Protein Processing [5]
Interleukin-2 (IL2) OTGI4NSA IL2_HUMAN Gene/Protein Processing [8]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Gene/Protein Processing [6]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Post-Translational Modifications [9]

References

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4 The orphan receptor GPR55 is a novel cannabinoid receptor. Br J Pharmacol. 2007 Dec;152(7):1092-101.
5 Cannabinoid CP55940 selectively induces apoptosis in Jurkat cells and in ex vivo T-cell acute lymphoblastic leukemia through H(2)O(2) signaling mechanism. Leuk Res. 2020 Aug;95:106389. doi: 10.1016/j.leukres.2020.106389. Epub 2020 May 26.
6 Stimulation of peripheral cannabinoid receptor CB2 induces MCP-1 and IL-8 gene expression in human promyelocytic cell line HL60. FEBS Lett. 1999 Apr 9;448(2-3):273-7. doi: 10.1016/s0014-5793(99)00380-4.
7 Synthetic cannabinoid CP-55,940 induces apoptosis in a human skeletal muscle model via regulation of CB(1) receptors and L-type Ca(2+) channels. Arch Toxicol. 2021 Feb;95(2):617-630. doi: 10.1007/s00204-020-02944-7. Epub 2020 Nov 10.
8 Anti-inflammatory and antinociceptive effects of the selective cannabinoid CB(2) receptor agonist ABK5. J Pharmacol Sci. 2021 Apr;145(4):319-326. doi: 10.1016/j.jphs.2020.12.006. Epub 2020 Dec 29.
9 Pyrimidinyl Biphenylureas Act as Allosteric Modulators to Activate Cannabinoid Receptor 1 and Initiate -Arrestin-Dependent Responses. Mol Pharmacol. 2019 Jan;95(1):1-10. doi: 10.1124/mol.118.112854. Epub 2018 Oct 15.
10 Posttraining activation of CB1 cannabinoid receptors in the CA1 region of the dorsal hippocampus impairs object recognition long-term memory. Neurobiol Learn Mem. 2008 Sep;90(2):374-81.
11 Novel 1',1'-chain substituted hexahydrocannabinols: 9-hydroxy-3-(1-hexyl-cyclobut-1-yl)-hexahydrocannabinol (AM2389) a highly potent cannabinoid r... J Med Chem. 2010 Oct 14;53(19):6996-7010.
12 Company report (Gwpharm)
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14 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
15 Emerging drugs for atopic dermatitis. Expert Opin Emerg Drugs. 2009 Mar;14(1):165-79.
16 The agonist binding mechanism of human CB2 receptor studied by molecular dynamics simulation, free energy calculation and 3D-QSAR studies. Yao Xue Xue Bao. 2013 Sep;48(9):1436-49.
17 The cannabinoid CB1 receptor-selective phytocannabinoid beta-caryophyllene exerts analgesic effects in mouse models of inflammatory and neuropathic pain. Eur Neuropsychopharmacol. 2014 Apr;24(4):608-20.
18 Clinical pipeline report, company report or official report of Roche
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20 Tetrahydrolipstatin analogues as modulators of endocannabinoid 2-arachidonoylglycerol metabolism. J Med Chem. 2008 Nov 13;51(21):6970-9.
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24 Surinabant, a selective cannabinoid receptor type 1 antagonist, inhibits 9-tetrahydrocannabinol-induced central nervous system and heart rate effects in humans.Br J Clin Pharmacol.2013 Jul;76(1):65-77.
25 Clinical pipeline report, company report or official report of Bird Rock Bio.
26 Clinical pipeline report, company report or official report of Affimed Therapeutics.
27 Clinical pipeline report, company report or official report of Biom Therapeutics
28 Screening beta-arrestin recruitment for the identification of natural ligands for orphan G-protein-coupled receptors. J Biomol Screen. 2013 Jun;18(5):599-609.
29 International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB and CB Pharmacol Rev. 2010 Dec;62(4):588-631.
30 Identification of the GPR55 agonist binding site using a novel set of high-potency GPR55 selective ligands. Biochemistry. 2011 Jun 28;50(25):5633-47.
31 A selective antagonist reveals a potential role of G protein-coupled receptor 55 in platelet and endothelial cell function. J Pharmacol Exp Ther. 2013 Jul;346(1):54-66.
32 Chronic Nucleoside Reverse Transcriptase Inhibitors Disrupt Mitochondrial Homeostasis and Promote Premature Endothelial Senescence. Toxicol Sci. 2019 Dec 1;172(2):445-456. doi: 10.1093/toxsci/kfz203.
33 Nicotinic modulation of gene expression in SH-SY5Y neuroblastoma cells. Brain Res. 2006 Oct 20;1116(1):39-49.
34 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
35 Silibinin inhibits ethanol- or acetaldehyde-induced ferroptosis in liver cell lines. Toxicol In Vitro. 2022 Aug;82:105388. doi: 10.1016/j.tiv.2022.105388. Epub 2022 May 18.
36 Rescue of Pink1 Deficiency by Stress-Dependent Activation of Autophagy. Cell Chem Biol. 2017 Apr 20;24(4):471-480.e4. doi: 10.1016/j.chembiol.2017.03.005. Epub 2017 Mar 30.
37 Induction of parkin expression in the presence of oxidative stress. Eur J Neurosci. 2006 Sep;24(5):1366-72. doi: 10.1111/j.1460-9568.2006.04998.x.
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