General Information of Disease (ID: DISXZG0T)

Disease Name Acute kidney injury
Synonyms kidney failure, acute; acute renal failure; acute kidney injury; ARF; AKI
Disease Class GB60-GB6Z: Kidney failure
Definition Sudden and sustained deterioration of the kidney function characterized by decreased glomerular filtration rate, increased serum creatinine or oliguria.
Disease Hierarchy
DIS070UC: Renal failure
DISBV50J: Acute disease
DISXZG0T: Acute kidney injury
ICD Code
ICD-11
ICD-11: GB60
ICD-9
ICD-9: 584
Expand ICD-9
584
Disease Identifiers
MONDO ID
MONDO_0002492
MESH ID
D058186
UMLS CUI
C2609414
MedGen ID
388570
HPO ID
HP:0001919

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 4 Clinical Trial Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
BQ788 DM6KRLW Phase 3 Small molecular drug [1]
EA-230 DM6P15C Phase 2 Peptide [2]
MB-102 DMLPNVS Phase 2 NA [3]
OPI-1002 DML6TAS Phase 2 siRNA drug [4]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 97 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
ECE1 TTQ9RYT Limited Biomarker [5]
IGF1R TTQFBMY Limited Biomarker [6]
B2M TTY7FKA Disputed Biomarker [7]
BAX TTQ57WJ Disputed Biomarker [8]
CLU TTRL76H Disputed Biomarker [7]
EGFR TTGKNB4 Disputed Therapeutic [9]
HBEGF TT15SL0 Disputed Biomarker [10]
HMOX1 TTI6V2A Disputed Therapeutic [11]
HP TTLC8E1 Disputed Biomarker [7]
MPO TTVCZPI Disputed Biomarker [8]
NFE2L2 TTA6ZN2 Disputed Biomarker [12]
NOS3 TTCM4B3 Disputed Biomarker [13]
NQO1 TT8XK6L Disputed Therapeutic [14]
PTAFR TTQL5VC Disputed Therapeutic [15]
SIRT1 TTUF2HO Disputed ModifyingMutation [16]
AHSG TTKF4WV Strong Biomarker [7]
ALB TTFNGC9 Strong Therapeutic [7]
AVP TTJ8EWH Strong Biomarker [17]
BDKRB2 TTGY8IW Strong Biomarker [18]
C3 TTJGY7A Strong Biomarker [7]
CCR5 TTJIH8Q Strong Biomarker [19]
CD44 TTWFBT7 Strong Biomarker [20]
CYP2C19 TTZ58XG Strong Biomarker [21]
CYP2C9 TTR40YJ Strong Biomarker [21]
CYP2D6 TTVG215 Strong Biomarker [21]
EDN1 TTJR60Z Strong Biomarker [22]
EPHX2 TT7WVHI Strong Therapeutic [23]
EPO TTQG4NR Strong Therapeutic [24]
G6PD TTKN8W0 Strong Biomarker [25]
GAS6 TT69QD2 Strong Biomarker [26]
GPNMB TT7315J Strong Biomarker [20]
GSK3B TTRSMW9 Strong Biomarker [27]
GSTA1 TT4P8DE Strong Biomarker [7]
GSTP1 TT40K12 Strong Biomarker [8]
HEXB TTKIBKM Strong Biomarker [28]
IFNA2 TTSIUJ9 Strong Biomarker [29]
IGF1 TTT6LOU Strong Therapeutic [30]
IGFBP1 TTCJTWF Strong Therapeutic [30]
IL20 TTNZMY2 Strong Biomarker [31]
INS TTZOPHG Strong Biomarker [32]
KLK1 TT5T3P6 Strong Therapeutic [33]
KNG1 TTDJ4MY Strong Therapeutic [34]
LCN2 TTKTLAI Strong Biomarker [35]
LRP2 TTPH1AJ Strong Biomarker [36]
MTHFR TTQWOU1 Strong Biomarker [37]
NFKB1 TTUIZKC Strong Biomarker [36]
NOS2 TTF10I9 Strong Biomarker [38]
PLG TTP86E2 Strong Biomarker [7]
POMC TT21AKM Strong Therapeutic [39]
PPARG TTT2SVW Strong Therapeutic [40]
PTGER4 TT79WV3 Strong Therapeutic [41]
RAPGEF3 TTOE7I0 Strong Biomarker [42]
SERPINA1 TTA7UJC Strong Biomarker [7]
SLC22A12 TTA592U Strong Biomarker [43]
SOD1 TTP9K3Q Strong Biomarker [7]
SPP1 TT8ME6I Strong Biomarker [8]
TF TT8WXAV Strong Biomarker [7]
THBD TTAPV67 Strong Therapeutic [44]
TLR2 TTY7ZHS Strong Biomarker [36]
TNFRSF12A TTKPS7V Strong Biomarker [20]
TTR TTPOYU7 Strong Biomarker [7]
UGT1A1 TT34ZAF Strong Biomarker [45]
ADRB2 TTG8ZWP Definitive Biomarker [46]
ALAD TTJHKYD Definitive Biomarker [47]
ALOX5 TTSJ6Q4 Definitive Biomarker [48]
ANXA1 TTUCK4B Definitive Therapeutic [49]
AR TTKPW01 Definitive Biomarker [50]
ARG1 TT7ZQEV Definitive Biomarker [51]
ARG2 TTV1AG6 Definitive Biomarker [51]
AVPR1A TT4TFGN Definitive Biomarker [52]
BCL2L1 TTRE6AX Definitive Biomarker [53]
CAPN1 TT1WBIJ Definitive Therapeutic [54]
CASP1 TTCQIBE Definitive Biomarker [55]
CDKN1B TTLGFVW Definitive Biomarker [55]
CRP TTWRN6M Definitive Biomarker [56]
CYP2E1 TTWVHQ5 Definitive Therapeutic [57]
EGF TTED8JB Definitive Biomarker [10]
EGLN1 TT9ISBX Definitive Biomarker [58]
EPAS1 TTWPA54 Definitive Therapeutic [59]
FN1 TTPJ921 Definitive Biomarker [60]
GSR TTEP6RV Definitive Biomarker [61]
HDAC3 TT4YWTO Definitive Biomarker [16]
HDAC5 TTUELN5 Definitive Biomarker [16]
HSPA8 TTMQL3K Definitive Biomarker [62]
ICAM1 TTA1L39 Definitive Therapeutic [63]
LGALS3 TTFPQV7 Definitive Biomarker [64]
MTOR TTCJG29 Definitive Biomarker [65]
NES TTHZ752 Definitive Biomarker [50]
NOS1 TTZUFI5 Definitive Biomarker [66]
NPPB TTY63XT Definitive Biomarker [67]
SCGB1A1 TTONPVW Definitive Biomarker [68]
SLC22A1 TTM5Q4V Definitive Therapeutic [69]
SLC22A2 TT0XOJN Definitive Therapeutic [69]
TGFA TTTLQFR Definitive Biomarker [10]
TLR4 TTISGCA Definitive Biomarker [36]
UTS2R TTW5UDX Definitive Biomarker [70]
XDH TT7RJY8 Definitive Therapeutic [71]
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⏷ Show the Full List of 97 DTT(s)
This Disease Is Related to 1 DTP Molecule(s)
Gene Name DTP ID Evidence Level Mode of Inheritance REF
SLC11A1 DT650XW Strong Biomarker [8]
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This Disease Is Related to 3 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
CYP27B1 DE3FYEM Disputed Biomarker [72]
UGT1A9 DE85D2P Strong Biomarker [8]
EGLN3 DEMQTKH Definitive Biomarker [58]
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This Disease Is Related to 34 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
PKD2 OTIXBU8H Limited Biomarker [73]
GATM OTIJ4Z11 Disputed Biomarker [74]
GFER OTVK43OK Disputed Therapeutic [75]
HAVCR1 OT184CRZ Disputed Biomarker [7]
NPPA OTMQNTNX Disputed Biomarker [67]
A2M OTFTX90K Strong Biomarker [20]
AFM OTPOR8IO Strong Biomarker [7]
AMBP OTLU8GU8 Strong Therapeutic [7]
AMN OTS1TJXG Strong Therapeutic [76]
ATP5F1B OTLFZUQK Strong Biomarker [77]
CP OTM8JE4Y Strong Biomarker [7]
CST3 OTNZ6AO4 Strong Biomarker [7]
FSTL1 OT6KEZUD Strong Biomarker [78]
GC OTWS63BY Strong Biomarker [7]
GSTM2 OTG4WT05 Strong Biomarker [8]
HBG2 OT4J48JJ Strong Biomarker [79]
HPX OT14T7Q1 Strong Biomarker [7]
HSPA1A OTKGIE76 Strong Biomarker [80]
OCLN OTSUTVWL Strong Biomarker [81]
ORM1 OTZKSBRE Strong Biomarker [7]
SLC22A24 OTNVZ8Z1 Strong Biomarker [82]
TFF3 OTJJDRTU Strong Biomarker [20]
ACE OTDF1964 Definitive Therapeutic [83]
BAD OT63ERYM Definitive Therapeutic [53]
DDIT3 OTI8YKKE Definitive Biomarker [84]
FGA OTMIHY80 Definitive Biomarker [85]
FIS1 OT2HL10J Definitive Biomarker [86]
GOT2 OT6XBWN0 Definitive Biomarker [87]
HES1 OT8P19W2 Definitive Biomarker [88]
MB OTYWYL2D Definitive Biomarker [89]
MFN1 OTCBXQZF Definitive Biomarker [86]
NDUFB8 OTW4A4Q0 Definitive Biomarker [90]
PROCR OTRHED17 Definitive Therapeutic [11]
RB1 OT9VMY7B Definitive Biomarker [91]
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⏷ Show the Full List of 34 DOT(s)

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 Clinical pipeline report, company report or official report of Exponential Biotherapies.
3 ClinicalTrials.gov (NCT02772276) Pharmacokinetics of MB-102 and Use of the Non-invasive Optical Renal Function Monitor (ORFM) Device in Subjects With Normal and Impaired Renal Function and a Range of Skin Color Types. U.S. National Institutes of Health.
4 2011 Pipeline of Quark Pharm.
5 Protective effect of SM-19712, a novel and potent endothelin converting enzyme inhibitor, on ischemic acute renal failure in rats. Jpn J Pharmacol. 2000 Sep;84(1):16-24.
6 IGF-I binding proteins, IGF-I binding protein mRNA and IGF-I receptor mRNA in rats with acute renal failure given IGF-I.Kidney Int. 1998 Oct;54(4):1070-82. doi: 10.1046/j.1523-1755.1998.00096.x.
7 A Multiplatform Approach for the Discovery of Novel Drug-Induced Kidney Injury Biomarkers.Chem Res Toxicol. 2017 Oct 16;30(10):1823-1834. doi: 10.1021/acs.chemrestox.7b00159. Epub 2017 Sep 27.
8 Phenotypic and genotypic assessment of concomitant drug-induced toxic effects in liver, kidney and blood.J Appl Toxicol. 2011 Mar;31(2):117-30. doi: 10.1002/jat.1562.
9 Importance of functional EGF receptors in recovery from acute nephrotoxic injury.J Am Soc Nephrol. 2003 Dec;14(12):3147-54. doi: 10.1097/01.asn.0000098681.56240.1a.
10 Control of the epidermal growth factor receptor and its ligands during renal injury.Nephron. 2001 May;88(1):71-9. doi: 10.1159/000045962.
11 Heme oxygenase 1 modulates thrombomodulin and endothelial protein C receptor levels to attenuate septic kidney injury.Shock. 2013 Aug;40(2):136-43. doi: 10.1097/SHK.0b013e31829d23f5.
12 Hepatic sulfotransferase as a nephropreventing target by suppression of the uremic toxin indoxyl sulfate accumulation in ischemic acute kidney injury.Toxicol Sci. 2014 Sep;141(1):206-17. doi: 10.1093/toxsci/kfu119. Epub 2014 Jun 23.
13 Gender Differences in the Acute Kidney Injury to Chronic Kidney Disease Transition.Sci Rep. 2017 Sep 25;7(1):12270. doi: 10.1038/s41598-017-09630-2.
14 S-AllylmercaptocysteineAttenuates Cisplatin-InducedNephrotoxicitythrough SuppressionofApoptosis,OxidativeStress,and Inflammation.Nutrients. 2017 Feb 20;9(2):166. doi: 10.3390/nu9020166.
15 Role of platelet activating factor in endotoxemic acute renal failure in the male rat.J Lab Clin Med. 1989 Mar;113(3):316-24.
16 Cisplatin induces Sirt1 in association with histone deacetylation and increased Werner syndrome protein in the kidney.Clin Exp Nephrol. 2011 Jun;15(3):363-372. doi: 10.1007/s10157-011-0421-5. Epub 2011 Mar 18.
17 Atrial natriuretic peptide reverses experimental acute renal failure induced by arginine vasopressin.Miner Electrolyte Metab. 1990;16(1):48-53.
18 Kinin B2 receptor deletion and blockage ameliorates cisplatin-induced acute renal injury.Int Immunopharmacol. 2014 Sep;22(1):115-9. doi: 10.1016/j.intimp.2014.06.025. Epub 2014 Jun 25.
19 CCR5 deficiency increased susceptibility to lipopolysaccharide-induced acute renal injury.Arch Toxicol. 2016 May;90(5):1151-62. doi: 10.1007/s00204-015-1530-9. Epub 2015 Jun 9.
20 Repeat oral dose toxicity studies of melamine in rats and monkeys.Arch Toxicol. 2013 Mar;87(3):517-27. doi: 10.1007/s00204-012-0939-7. Epub 2012 Sep 28.
21 Acute kidney injury in patients with inactive cytochrome P450 polymorphisms. Ren Fail. 2009;31(8):749-52. doi: 10.3109/08860220903118608.
22 Altered expression of endothelin-1 and endothelial nitric oxide synthase in the juxtaglomerular apparatus of rats with HgCl2-induced acute renal failure.Toxicol Lett. 1998 Sep 15;98(3):181-8. doi: 10.1016/s0378-4274(98)00122-2.
23 Change in soluble epoxide hydrolase (sEH) during cisplatin-induced acute renal failure in mice.J Toxicol Sci. 2015 Aug;40(4):451-7. doi: 10.2131/jts.40.451.
24 Amelioration of lipopolysaccharide-induced acute kidney injury by erythropoietin: involvement of mitochondria-regulated apoptosis.Toxicology. 2014 Apr 6;318:13-21. doi: 10.1016/j.tox.2014.01.011. Epub 2014 Feb 20.
25 Acute renal failure due to intravascular hemolysis in the North Indian patients.Am J Med Sci. 1977 Sep-Oct;274(2):139-46. doi: 10.1097/00000441-197709000-00004.
26 Growth arrest specific protein 6 participates in DOCA-induced target-organ damage.Hypertension. 2009 Aug;54(2):359-64. doi: 10.1161/HYPERTENSIONAHA.109.129460. Epub 2009 Jun 29.
27 Specific deletion of glycogen synthase kinase-3 in the renal proximal tubule protects against acute nephrotoxic injury in mice.Kidney Int. 2012 Nov;82(9):1000-9. doi: 10.1038/ki.2012.239. Epub 2012 Jul 11.
28 Decrease in urinary creatinine in acute kidney injury influences diagnostic value of urinary biomarker-to-creatinine ratio in rats.Toxicology. 2011 Dec 18;290(2-3):241-8. doi: 10.1016/j.tox.2011.10.001. Epub 2011 Oct 8.
29 Phase II trial of cisplatin, 5-fluorouracil, and interferon-alpha-2B as first line treatment of advanced urothelial cancer.Urol Oncol. 2003 May-Jun;21(3):185-9. doi: 10.1016/s1078-1439(02)00204-1.
30 Insulin-like growth factor-1 (IGF-1) enhances recovery from HgCl2-induced acute renal failure: the effects on renal IGF-1, IGF-1 receptor, and IGF-binding protein-1 mRNA.J Am Soc Nephrol. 1995 Apr;5(10):1782-91. doi: 10.1681/ASN.V5101782.
31 Interleukin-20 induced cell death in renal epithelial cells and was associated with acute renal failure.Genes Immun. 2008 Jul;9(5):395-404. doi: 10.1038/gene.2008.28. Epub 2008 May 22.
32 Rhabdomyolysis with concurrent atorvastatin and diltiazem.Ann Pharmacother. 2002 Oct;36(10):1546-9. doi: 10.1345/aph.1A481.
33 Role of tissue kallikrein in prevention and recovery of gentamicin-induced renal injury.Toxicol Sci. 2008 Apr;102(2):433-43. doi: 10.1093/toxsci/kfn008. Epub 2008 Jan 27.
34 The role of high-energy phosphate in norepinephrine-induced acute renal failure in the dog.Circ Res. 1986 Jul;59(1):93-104. doi: 10.1161/01.res.59.1.93.
35 Neutrophil gelatinase-associated lipocalin production negatively correlates with HK-2 cell impairment: Evaluation of NGAL as a marker of toxicity in HK-2 cells. Toxicol In Vitro. 2017 Mar;39:52-57. doi: 10.1016/j.tiv.2016.11.012. Epub 2016 Nov 22.
36 Relevance of megalin receptor injury with nuclear factor-kappa B upregulation in acute kidney injury induced in rats.J Biochem Mol Toxicol. 2018 Jan;32(1). doi: 10.1002/jbt.22014. Epub 2017 Dec 29.
37 Renal failure after high-dose methotrexate in a child homozygous for MTHFR C677T polymorphism.Pediatr Blood Cancer. 2008 Jan;50(1):154-6. doi: 10.1002/pbc.21176.
38 Inducible nitric oxide synthase expression in mercury chloride-induced acute tubular necrosis.Ind Health. 1998 Oct;36(4):324-30. doi: 10.2486/indhealth.36.324.
39 The effect of alpha-melanocyte stimulating hormone on gentamicin-induced acute nephrotoxicity in rats.J Appl Toxicol. 2007 Mar-Apr;27(2):183-8. doi: 10.1002/jat.1191.
40 Explicit role of peroxisome proliferator-activated receptor gamma in gallic acid-mediated protection against ischemia-reperfusion-induced acute kidney injury in rats.J Surg Res. 2014 Apr;187(2):631-9. doi: 10.1016/j.jss.2013.11.1088. Epub 2013 Nov 22.
41 Role of EP2 and EP4 receptor-selective agonists of prostaglandin E(2) in acute and chronic kidney failure.Kidney Int. 2006 Sep;70(6):1099-106. doi: 10.1038/sj.ki.5001715. Epub 2006 Jul 26.
42 cAMP signalling protects proximal tubular epithelial cells from cisplatin-induced apoptosis via activation of Epac.Br J Pharmacol. 2012 Feb;165(4b):1137-50. doi: 10.1111/j.1476-5381.2011.01594.x.
43 Two male siblings with hereditary renal hypouricemia and exercise-induced ARF.Am J Kidney Dis. 2003 Dec;42(6):1287-92. doi: 10.1053/j.ajkd.2003.08.032.
44 Soluble thrombomodulin protects ischemic kidneys.J Am Soc Nephrol. 2009 Mar;20(3):524-34. doi: 10.1681/ASN.2008060593. Epub 2009 Jan 28.
45 Salicylate nephropathy in the Gunn rat: potential role of prostaglandins.Prostaglandins. 1985 Sep;30(3):511-25. doi: 10.1016/0090-6980(85)90123-6.
46 Renal beta(2)-adrenoceptor modulates the lipopolysaccharide transport system in sepsis-induced acute renal failure.Inflammation. 2009 Feb;32(1):12-9. doi: 10.1007/s10753-008-9097-8.
47 Diphenyl diselenide protects against glycerol-induced renal damage in rats.J Appl Toxicol. 2009 Oct;29(7):612-8. doi: 10.1002/jat.1449.
48 Post-treatment effects of erythropoietin and nordihydroguaiaretic acid on recovery from cisplatin-induced acute renal failure in the rat.J Korean Med Sci. 2009 Jan;24 Suppl(Suppl 1):S170-5. doi: 10.3346/jkms.2009.24.S1.S170. Epub 2009 Jan 29.
49 Annexin A1 protein attenuates cyclosporine-induced renal hemodynamics changes and macrophage infiltration in rats.Inflamm Res. 2012 Mar;61(3):189-96. doi: 10.1007/s00011-011-0400-z. Epub 2011 Nov 19.
50 Identification of nestin as a urinary biomarker for acute kidney injury.Am J Nephrol. 2014;39(2):110-21. doi: 10.1159/000358260. Epub 2014 Feb 6.
51 L-Arginine transport is augmented through up-regulation of tubular CAT-2 mRNA in ischemic acute renal failure in rats.Kidney Int. 2002 Nov;62(5):1700-6. doi: 10.1046/j.1523-1755.2002.t01-1-00622.x.
52 Early, but not late therapy with a vasopressin V1a-antagonist ameliorates the development of renal damage after 5/6 nephrectomy.J Renin Angiotensin Aldosterone Syst. 2006 Dec;7(4):217-24. doi: 10.3317/jraas.2006.041.
53 N-acetylcysteine attenuates glycerol-induced acute kidney injury by regulating MAPKs and Bcl-2 family proteins.Nephrol Dial Transplant. 2010 May;25(5):1435-43. doi: 10.1093/ndt/gfp659. Epub 2009 Dec 27.
54 Perspective on rhabdomyolysis-induced acute kidney injury and new treatment options.Am J Nephrol. 2013;38(5):368-78. doi: 10.1159/000355537. Epub 2013 Oct 22.
55 Role of caspases on cell death, inflammation, and cell cycle in glycerol-induced acute renal failure.Kidney Int. 2006 Apr;69(8):1385-92. doi: 10.1038/sj.ki.5000315.
56 Role of quercetin and arginine in ameliorating nano zinc oxide-induced nephrotoxicity in rats.BMC Complement Altern Med. 2012 May 2;12:60. doi: 10.1186/1472-6882-12-60.
57 Inhibition of cytochrome P450 2E1 and activation of transcription factor Nrf2 are renoprotective in myoglobinuric acute kidney injury.Kidney Int. 2014 Aug;86(2):338-49. doi: 10.1038/ki.2014.65. Epub 2014 Apr 9.
58 HIF-prolyl hydroxylases in the rat kidney: physiologic expression patterns and regulation in acute kidney injury.Am J Pathol. 2009 May;174(5):1663-74. doi: 10.2353/ajpath.2009.080687. Epub 2009 Apr 6.
59 Preconditional activation of hypoxia-inducible factors ameliorates ischemic acute renal failure.J Am Soc Nephrol. 2006 Jul;17(7):1970-8. doi: 10.1681/ASN.2005121302. Epub 2006 Jun 8.
60 Important role for fibronectin-EIIIA during renal tubular repair and cellular recovery in uranyl acetate-induced acute renal failure of rats.Virchows Arch. 2003 Aug;443(2):194-205. doi: 10.1007/s00428-003-0846-7. Epub 2003 Jul 17.
61 Effects of glycerol-induced acute renal failure on tissue glutathione and glutathione-dependent enzymes in the rat.Methods Find Exp Clin Pharmacol. 1991 Jan-Feb;13(1):23-8.
62 73-kDa molecular chaperone HSP73 is a direct target of antibiotic gentamicin.J Biol Chem. 2004 Apr 23;279(17):17295-300. doi: 10.1074/jbc.M312217200. Epub 2004 Feb 13.
63 Erythropoietin attenuates cardiopulmonary bypass-induced renal inflammatory injury by inhibiting nuclear factor-B p65 expression.Eur J Pharmacol. 2012 Aug 15;689(1-3):154-9. doi: 10.1016/j.ejphar.2012.05.027. Epub 2012 May 30.
64 Up-regulation of galectin-3 in acute renal failure of the rat.Am J Pathol. 2000 Sep;157(3):815-23. doi: 10.1016/S0002-9440(10)64595-6.
65 Involvement of autophagy in the pharmacological effects of the mTOR inhibitor everolimus in acute kidney injury.Eur J Pharmacol. 2012 Dec 5;696(1-3):143-54. doi: 10.1016/j.ejphar.2012.09.010. Epub 2012 Sep 26.
66 Renal neuronal nitric oxide synthase protein expression as a marker of renal injury.Kidney Int. 2003 Nov;64(5):1765-71. doi: 10.1046/j.1523-1755.2003.00260.x.
67 Altered regulation of nitric oxide and natriuretic peptide system in cisplatin-induced nephropathy.Regul Pept. 2012 Feb 10;174(1-3):65-70. doi: 10.1016/j.regpep.2011.12.001. Epub 2011 Dec 28.
68 Modulation of aquaporin-2/vasopressin2 receptor kidney expression and tubular injury after endotoxin (lipopolysaccharide) challenge.Crit Care Med. 2008 Nov;36(11):3054-61. doi: 10.1097/CCM.0b013e318186a938.
69 Regulation of renal organic anion and cation transporters by thymoquinone in cisplatin induced kidney injury.Food Chem Toxicol. 2012 May;50(5):1675-9. doi: 10.1016/j.fct.2012.02.082. Epub 2012 Mar 3.
70 Pharmacology of the urotensin-II receptor antagonist palosuran (ACT-058362; 1-[2-(4-benzyl-4-hydroxy-piperidin-1-yl)-ethyl]-3-(2-methyl-quinolin-4-yl)-urea sulfate salt): first demonstration of a pathophysiological role of the urotensin System.J Pharmacol Exp Ther. 2004 Oct;311(1):204-12. doi: 10.1124/jpet.104.068320. Epub 2004 May 14.
71 Nephroprotective efficacy of chrysin against cisplatin-induced toxicity via attenuation of oxidative stress.J Pharm Pharmacol. 2012 Jun;64(6):872-81. doi: 10.1111/j.2042-7158.2012.01470.x. Epub 2012 Mar 22.
72 Changes in 25-hydroxyvitamin D3 alpha- and 24-hydroxylase activities of kidney cells isolated from rats with either unilateral kidney damage or acute renal insufficiency.Endocrinology. 1983 Aug;113(2):476-84. doi: 10.1210/endo-113-2-476.
73 Altered expression pattern of polycystin-2 in acute and chronic renal tubular diseases.J Am Soc Nephrol. 2002 Jul;13(7):1855-64. doi: 10.1097/01.asn.0000018402.33620.c7.
74 Interrelation of urinary and plasma levels of guanidinoacetic acid with alteration in renal activity of glycine amidinotransferase in acute renal failure rats.Chem Pharm Bull (Tokyo). 1989 Mar;37(3):781-4. doi: 10.1248/cpb.37.781.
75 Expression of augmenter of liver regeneration in rats with gentamicin-induced acute renal failure and its protective effect on kidney.Ren Fail. 2009;31(10):946-55. doi: 10.3109/08860220903216154.
76 Pituitary adenylate cyclase-activating polypeptide prevents cisplatin-induced renal failure.J Mol Neurosci. 2011 Jan;43(1):58-66. doi: 10.1007/s12031-010-9394-1. Epub 2010 Jun 1.
77 Urinary ATP Synthase Subunit Is a Novel Biomarker of Renal Mitochondrial Dysfunction in Acute Kidney Injury.Toxicol Sci. 2015 May;145(1):108-17. doi: 10.1093/toxsci/kfv038. Epub 2015 Feb 9.
78 Follistatin-like 1 regulates renal IL-1 expression in cisplatin nephrotoxicity.Am J Physiol Renal Physiol. 2010 Dec;299(6):F1320-7. doi: 10.1152/ajprenal.00325.2010. Epub 2010 Sep 22.
79 Morphologic demonstration of tubular obstruction in acute renal failure.Am J Pathol. 1977 May;87(2):323-30.
80 Heat shock protein 72 protects kidney proximal tubule cells from injury induced by triptolide by means of activation of the MEK/ERK pathway. Int J Toxicol. 2009 May-Jun;28(3):177-89. doi: 10.1177/1091581809337418.
81 The protective effect of alpha-tocopherol against dichromate-induced renal tight junction damage is mediated via ERK1/2.Toxicol Lett. 2009 Dec 15;191(2-3):279-88. doi: 10.1016/j.toxlet.2009.09.011. Epub 2009 Sep 17.
82 Organic Anion Transporter 5 (Oat5) Urinary Excretion Is a Specific Biomarker of Kidney Injury: Evaluation of Urinary Excretion of Exosomal Oat5 after N-Acetylcysteine Prevention of Cisplatin Induced Nephrotoxicity.Chem Res Toxicol. 2015 Aug 17;28(8):1595-602. doi: 10.1021/acs.chemrestox.5b00176. Epub 2015 Aug 7.
83 The restoration of kidney mitochondria function by inhibition of angiotensin-II production in rats with acute adriamycin-induced nephrotoxicity.Ren Fail. 2014 May;36(4):606-12. doi: 10.3109/0886022X.2014.882737. Epub 2014 Feb 6.
84 The induction of cell cycle regulatory and DNA repair proteins in cisplatin-induced acute renal failure.Toxicol Appl Pharmacol. 2004 Oct 15;200(2):111-20. doi: 10.1016/j.taap.2004.04.003.
85 Prediction of nephrotoxicant action and identification of candidate toxicity-related biomarkers.Toxicol Pathol. 2005;33(3):343-55. doi: 10.1080/01926230590927230.
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