Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMRWLB2)

Drug Name
Fluticasone propionate Drug Info
Synonyms
FLUTICASONE PROPIONATE; Flovent; Cutivate; Flixotide; Flonase; Flixonase; Flovent HFA; Flunase; Flutide; Fluspiral; Flusonal; atemur; Flutivate; Fluinol; Axotide; Asmatil; Brethal; Flovent Diskus 50; Flixotide Disks; Flixotide Disk; Flovent Diskus; Flovent Diskus 100; Flovent Diskus 250; Flixotide Inhaler; Trialona; Rinosone; Inalacor; Cultivate; Ubizol; Zoflut; Flixonase Nasal Spray; Flonase Aq; Fluticasonpropionat Allen; Fluticasone (propionate); UNII-O2GMZ0LF5W; CCI-18781; CCI 18781; MFCD00866007; O2GMZ0LF5W
Indication
Disease Entry ICD 11 Status REF
Allergic asthma CA23.0 Approved [1]
Allergic rhinitis CA08.0 Approved [1]
Bronchiolitis Approved [1]
Exanthem Approved [1]
Granuloma annulare Approved [1]
Intrinsic asthma Approved [1]
Primary cutaneous T-cell lymphoma Approved [1]
Pulmonary emphysema CA21.Z Approved [1]
Cross-matching ID
PubChem CID
444036
ChEBI ID
CHEBI:31441
CAS Number
CAS 80474-14-2
TTD Drug ID
DMRWLB2
VARIDT Drug ID
DR01643

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTP
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [10]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [11]
Methotrexate DM2TEOL Anterior urethra cancer Approved [12]
Folic Acid DMEMBJC Colorectal carcinoma Approved [13]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [12]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [12]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [14]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [12]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [15]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [16]
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Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [17]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [18]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [19]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [20]
Cepharanthine DM9Y5JB N. A. N. A. Approved [21]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [22]
Clozapine DMFC71L Schizophrenia 6A20 Approved [23]
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [24]
Trifluoperazine DMKBYWI Anxiety Approved [25]
Olanzapine DMPFN6Y Bipolar depression Approved [23]
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Drug(s) Affected By Glutathione hydrolase 5 proenzyme (GGT5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [26]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [27]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [30]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [31]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [32]
Beclomethasone dipropionate DM5NW1E Allergic rhinitis CA08.0 Phase 4 [8]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [33]
Maleic Acid DM4L0R7 Discovery agent N.A. Investigative [34]
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Drug(s) Affected By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eplerenone DMF0NQR Heart failure BD10-BD13 Approved [35]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [36]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [37]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [38]
Proguanil DMBL79I Malaria 1F40-1F45 Approved [39]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [39]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [40]
Nelfinavir mesylate DMFX6G8 N. A. N. A. Approved [41]
Capsaicin DMGMF6V Back pain ME84.Z Approved [42]
Axitinib DMGVH6N Renal cell carcinoma 2C90 Approved [43]
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Drug(s) Affected By Cytochrome P450 3A5 (CYP3A5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eplerenone DMF0NQR Heart failure BD10-BD13 Approved [35]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [36]
Nelfinavir mesylate DMFX6G8 N. A. N. A. Approved [41]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [41]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [44]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [45]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [46]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [33]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [47]
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Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [48]
Vidarabine DM0N85H Hepatosplenic T-cell lymphoma Approved [48]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [49]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [50]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [51]
Etidronic acid DM1XHYJ Bone Paget disease Approved [48]
Tiaprofenic acid DM23D7J Osteoarthritis FA00-FA05 Approved [48]
Bromperidol DM24XYQ Schizophrenia 6A20 Approved [48]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [52]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [53]
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Drug(s) Affected By Osteocalcin (BGLAP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [54]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [55]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [56]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [57]
Quercetin DM3NC4M Obesity 5B81 Approved [58]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [59]
Pamidronate DMB4AVP Bone Paget disease Approved [60]
Falecalcitrol DMBI9ZJ Hyperparathyroidism 5A51 Approved [61]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [62]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [63]
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Drug(s) Affected By Antileukoproteinase (SLPI)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [64]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [64]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [65]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [64]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [64]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [64]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [64]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [27]
Penbutolol DM4ES8F Hypertension BA00-BA04 Approved [64]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [64]
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Drug(s) Affected By Annexin A1 (ANXA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [66]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [67]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Panobinostat DM58WKG Chronic graft versus host disease Approved [69]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [70]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [71]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [72]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [73]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [67]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [33]
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Drug(s) Affected By Granulocyte-macrophage colony-stimulating factor (CSF2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [74]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [76]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [77]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [78]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [79]
Testosterone DM7HUNW Hot flushes GA30 Approved [80]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [81]
Acetylcholine DMDF79Z Cataract 9B10 Approved [82]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [83]
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Drug(s) Affected By Glucocorticoid receptor (NR3C1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [84]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [85]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [65]
Selenium DM25CGV N. A. N. A. Approved [86]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [87]
Methotrexate DM2TEOL Anterior urethra cancer Approved [88]
Quercetin DM3NC4M Obesity 5B81 Approved [58]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [89]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [90]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [91]
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Drug(s) Affected By Interleukin-5 (IL5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [92]
Tolnaftate DM28MU7 Dermatophytosis 1F28.2 Approved [93]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [94]
Prednisone DM2HG4X Acute asthma CA23 Approved [95]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [96]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [97]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [98]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [99]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [101]
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Drug(s) Affected By Protein kinase C alpha type (PRKCA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [102]
Quercetin DM3NC4M Obesity 5B81 Approved [103]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [104]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [27]
Panobinostat DM58WKG Chronic graft versus host disease Approved [69]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [105]
Leflunomide DMR8ONJ Arthritis FA20 Approved [106]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [107]
Capsaicin DMGMF6V Back pain ME84.Z Approved [108]
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Drug(s) Affected By Serum paraoxonase/arylesterase 1 (PON1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [109]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [110]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [111]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [112]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [113]
Quercetin DM3NC4M Obesity 5B81 Approved [114]
Panobinostat DM58WKG Chronic graft versus host disease Approved [69]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [115]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [116]
Gabapentin DM6T924 Complex partial seizure 8A68.0 Approved [109]
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Drug(s) Affected By Dual specificity protein phosphatase 1 (DUSP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [117]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [118]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [119]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [120]
Methotrexate DM2TEOL Anterior urethra cancer Approved [121]
Quercetin DM3NC4M Obesity 5B81 Approved [58]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [122]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [123]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [124]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [125]
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Drug(s) Affected By Cytosolic phospholipase A2 (PLA2G4A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [126]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [127]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [90]
Panobinostat DM58WKG Chronic graft versus host disease Approved [69]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [128]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [33]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [129]
Capsaicin DMGMF6V Back pain ME84.Z Approved [130]
Budesonide DMJIBAW Allergic rhinitis CA08.0 Approved [131]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [132]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Annexin A1 (ANXA1) OT5OFDJC ANXA1_HUMAN Protein Interaction/Cellular Processes [3]
Antileukoproteinase (SLPI) OTUNFUU8 SLPI_HUMAN Gene/Protein Processing [4]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Regulation of Drug Effects [5]
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Gene/Protein Processing [6]
Cytochrome P450 3A5 (CYP3A5) OTSXFBXB CP3A5_HUMAN Gene/Protein Processing [7]
Cytosolic phospholipase A2 (PLA2G4A) OTE70SOT PA24A_HUMAN Protein Interaction/Cellular Processes [3]
Dual specificity protein phosphatase 1 (DUSP1) OTN6BR75 DUS1_HUMAN Gene/Protein Processing [4]
Glucocorticoid receptor (NR3C1) OTCI2YDI GCR_HUMAN Protein Interaction/Cellular Processes [4]
Glutathione hydrolase 5 proenzyme (GGT5) OTDJYEO7 GGT5_HUMAN Gene/Protein Processing [8]
Granulocyte-macrophage colony-stimulating factor (CSF2) OT1M7D28 CSF2_HUMAN Protein Interaction/Cellular Processes [9]

References

1 Fluticasone propionate FDA Label
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5 Oral and inhaled corticosteroids: differences in P-glycoprotein (ABCB1) mediated efflux. Toxicol Appl Pharmacol. 2012 May 1;260(3):294-302. doi: 10.1016/j.taap.2012.03.008. Epub 2012 Mar 23.
6 The inhaled glucocorticoid fluticasone propionate efficiently inactivates cytochrome P450 3A5, a predominant lung P450 enzyme. Chem Res Toxicol. 2010 Aug 16;23(8):1356-64.
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19 Editor's Highlight: PlacentalDisposition and Effects of Crizotinib: An Ex Vivo Study in the Isolated Dual-Side Perfused Human Cotyledon. Toxicol Sci. 2017 Jun 1;157(2):500-509. doi: 10.1093/toxsci/kfx063.
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27 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
28 Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
29 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
30 Endometrial receptivity is affected in women with high circulating progesterone levels at the end of the follicular phase: a functional genomics analysis. Hum Reprod. 2011 Jul;26(7):1813-25.
31 Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
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34 Profiling transcriptomes of human SH-SY5Y neuroblastoma cells exposed to maleic acid. PeerJ. 2017 Apr 5;5:e3175.
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36 Characterization of the structural determinants required for potent mechanism-based inhibition of human cytochrome P450 1A1 by cannabidiol. Chem Biol Interact. 2014 May 25;215:62-8.
37 Retinoids activate the RXR/SXR-mediated pathway and induce the endogenous CYP3A4 activity in Huh7 human hepatoma cells. Toxicol Sci. 2006 Jul;92(1):51-60.
38 The novel azole R126638 is a selective inhibitor of ergosterol synthesis in Candida albicans, Trichophyton spp., and Microsporum canis. Antimicrob Agents Chemother. 2004 Sep;48(9):3272-8.
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40 Cetirizine and loratadine-based antihistamines with 5-lipoxygenase inhibitory activity. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5591-4.
41 Mechanism-based inactivation of CYP3A by HIV protease inhibitors. J Pharmacol Exp Ther. 2005 Feb;312(2):583-91.
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43 Investigation of the effects of axitinib on the pharmacokinetics of loperamide and its main metabolite N-demethylated loperamide in rats by UPLC-MS/MS. Chem Biol Interact. 2019 Sep 1;310:108744. doi: 10.1016/j.cbi.2019.108744. Epub 2019 Jul 9.
44 Contribution of CYP3A5 to hepatic and renal ifosfamide N-dechloroethylation. Drug Metab Dispos. 2005 Jul;33(7):1074-81. doi: 10.1124/dmd.104.002279. Epub 2005 Apr 8.
45 Use of mRNA expression to detect the induction of drug metabolising enzymes in rat and human hepatocytes. Toxicol Appl Pharmacol. 2009 Feb 15;235(1):86-96.
46 Induction of human cytochrome P450 3A enzymes in cultured placental cells by thalidomide and relevance to bioactivation and toxicity. J Toxicol Sci. 2017;42(3):343-348.
47 Induction of hepatic CYP3A enzymes by pregnancy-related hormones: studies in human hepatocytes and hepatic cell lines. Drug Metab Dispos. 2013 Feb;41(2):281-90.
48 Screening of a chemical library reveals novel PXR-activating pharmacologic compounds. Toxicol Lett. 2015 Jan 5;232(1):193-202. doi: 10.1016/j.toxlet.2014.10.009. Epub 2014 Oct 16.
49 Induction of PXR-mediated metabolism by beta-carotene. Biochim Biophys Acta. 2005 May 30;1740(2):162-9. doi: 10.1016/j.bbadis.2004.11.013. Epub 2004 Dec 8.
50 Lignans, bacteriocides and organochlorine compounds activate the human pregnane X receptor (PXR). Toxicol Appl Pharmacol. 2005 Dec 1;209(2):123-33. doi: 10.1016/j.taap.2005.03.015.
51 Identification and validation of novel human pregnane X receptor activators among prescribed drugs via ligand-based virtual screening. Drug Metab Dispos. 2011 Feb;39(2):337-44. doi: 10.1124/dmd.110.035808. Epub 2010 Nov 10.
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