Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM3Q1SM)

• Drug Name: obeticholic acid Drug Info
• Synonyms: INT747; INT-747; 6-ethylchenodeoxycholic acid; 6-ECDCA; OCA; 6-Et CDCA

Indication

Disease Entry	ICD 11	Status	REF
Primary biliary cholangitis	DB96.1	Approved	[1]
Insomnia	7A00-7A0Z	Clinical trial	[2]

• Cross-matching ID:
  PubChem CID: 447715
  ChEBI ID: CHEBI:43602
  CAS Number: CAS 459789-99-2
  TTD Drug ID: DM3Q1SM
  INTEDE Drug ID: DR1183
  ACDINA Drug ID: D00482

Molecule-Related Drug Atlas

Drug(s) Targeting Farnesoid X-activated receptor (FXR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Chenodiol	DMQ8JIK	Cholelithiasis	DC11	Approved	[5]
Guggulsterone	DMP7LK1	Osteoarthritis	FA00-FA05	Approved	[6]
GS-9674	DM936V7	Primary sclerosing cholangitis	DB96.2	Phase 3	[7]
Apomine	DM6B9HP	Osteopetrosis	LD24.10	Phase 2	[8]
LJN452	DM3XRUH	Primary biliary cholangitis	DB96.1	Phase 2	[9]
EYP001	DM5PBLM	Non-alcoholic steatohepatitis	DB92.1	Phase 2	[10]
EDP-305	DMGJYZ8	Non-alcoholic steatohepatitis	DB92.1	Phase 2	[11]
LMB763	DMQOXNL	Diabetic nephropathy	GB61.Z	Phase 2	[12]
MET409	DM89QXT	Non-alcoholic steatohepatitis	DB92.1	Phase 2	[13]
Turofexorate isopropyl	DM36ONA	Hyperlipidaemia	5C80	Phase 1	[14]

Drug(s) Metabolized By Bile acid-CoA thioesterase (BAAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glycine	DMIOZ29	Allergic rhinitis	CA08.0	Approved	[15]
taurine	DMVW7N3	Discovery agent	N.A.	Investigative	[15]
ZX-AP000068	DM4Y0NI	N. A.	N. A.	Investigative	[15]
NSC-39851	DMMXZBK	N. A.	N. A.	Investigative	[15]

Drug(s) Affected By Very long chain fatty acid elongase 7 (ELOVL7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[16]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[19]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[20]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[21]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[20]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[22]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[23]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[24]

Drug(s) Affected By cTAGE family member 15 (CTAGE15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[23]

Drug(s) Affected By Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PIK3CD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[25]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[29]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[30]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[31]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[32]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[33]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[30]

Drug(s) Affected By Nuclear receptor subfamily 5 group A member 2 (NR5A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[16]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[37]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[38]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[39]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[40]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[41]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[35]

Drug(s) Affected By Suppressor of cytokine signaling 2 (SOCS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[42]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[44]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[45]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[46]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[47]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]

Drug(s) Affected By Copper chaperone for superoxide dismutase (CCS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[50]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[53]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[54]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[55]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[29]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[39]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[41]

Drug(s) Affected By Ectoderm-neural cortex protein 1 (ENC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[16]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[58]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[59]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[47]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[60]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[61]

Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 7 (MAP2K7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[62]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[21]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[63]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[22]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[26]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[64]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[23]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[65]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[66]

Drug(s) Affected By 1-acyl-sn-glycerol-3-phosphate acyltransferase beta (AGPAT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[44]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[67]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[68]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[61]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[69]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[70]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[29]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[71]

Drug(s) Affected By Peroxisomal acyl-coenzyme A oxidase 3 (ACOX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[45]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[41]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[23]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[73]

Drug(s) Affected By Tapasin (TAPBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[66]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[75]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[40]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[63]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[76]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[23]

Drug(s) Affected By Interleukin-1 receptor-associated kinase-like 2 (IRAK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[77]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[46]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[47]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[37]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[78]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[79]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[75]

Drug(s) Affected By Long-chain-fatty-acid--CoA ligase 4 (ACSL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[80]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[29]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[84]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[63]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[85]

Drug(s) Affected By Transcription factor Maf (MAF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[16]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[20]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[86]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[87]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[88]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[50]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[89]

Drug(s) Affected By Ribosomal protein S6 kinase alpha-5 (RPS6KA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[90]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[91]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[46]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[93]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[61]
Ximelegatran	DMU8ANS	Myocardial infarction	BA41-BA43	Approved	[94]

Drug(s) Affected By Ribosomal protein S6 kinase alpha-4 (RPS6KA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[95]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[61]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[63]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[96]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[97]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[24]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[65]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[65]

Drug(s) Affected By Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial (SLC25A12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[61]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[29]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[98]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[99]

Drug(s) Affected By Lathosterol oxidase (SC5D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[50]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[100]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[101]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[67]
Haloperidol	DM96SE0	Delirium		Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[101]

Drug(s) Affected By Phospholipid-transporting ATPase ABCA1 (ABCA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[102]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[103]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[81]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[104]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[105]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[106]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[107]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[108]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[109]

Drug(s) Affected By Fibroblast growth factor 19 (FGF19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[110]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[80]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[111]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[112]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[113]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[68]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[111]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[93]

Drug(s) Affected By Alcohol dehydrogenase 1C (ADH1C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[114]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[78]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[115]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[116]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[115]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[117]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[78]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[118]

Drug(s) Affected By Glutathione reductase, mitochondrial (GSR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[119]
Ketoprofen	DMRKXPT	Bursitis		Approved	[120]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[121]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[122]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[110]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[124]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[125]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[126]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[121]

Drug(s) Affected By Alpha-1-antitrypsin (SERPINA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[127]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[50]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[95]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[128]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[129]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[75]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[130]

Drug(s) Affected By Alpha-2-macroglobulin (A2M)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[131]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[132]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[100]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[117]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Aminocaproic Acid	DMFGND4	Bleeding disorder	GA20-GA21	Approved	[132]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[134]

Drug(s) Affected By Metalloproteinase inhibitor 1 (TIMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pentoxifylline	DMU3DNC	Alcoholic hepatitis	DB94.1	Approved	[120]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[135]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[136]
Selenium	DM25CGV	N. A.	N. A.	Approved	[137]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[136]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[138]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[139]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[140]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[141]

Drug(s) Affected By Protein c-Fos (FOS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[142]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[90]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[143]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[144]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[143]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[145]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[146]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[147]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[148]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[149]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[150]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[144]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[145]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[151]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[152]
Selenium	DM25CGV	N. A.	N. A.	Approved	[153]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[154]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[155]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[156]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[80]

Drug(s) Affected By GTPase HRas (HRAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[157]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[158]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[159]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[95]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[160]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[161]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[162]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]

Drug(s) Affected By Low-density lipoprotein receptor (LDLR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[163]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[164]
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[163]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[165]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[166]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[167]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[100]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[101]

Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[168]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[120]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[25]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[169]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[170]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[171]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[172]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[173]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[174]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[80]

Drug(s) Affected By Collagen alpha-1(I) chain (COL1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[120]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[175]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[176]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[177]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[178]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[179]
Ceruletide	DM2WE5K	Caerulein stimulated gastric and pancreatic secretion	5A4Y	Approved	[180]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[181]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[182]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[183]

Drug(s) Affected By Apolipoprotein A-I (APOA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[184]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[185]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[186]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[187]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[188]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[190]
Gemfibrozil	DMD8Q3J	Hyperlipidaemia	5C80	Approved	[191]

Drug(s) Affected By Apolipoprotein E (APOE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[192]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[193]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[77]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[194]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[59]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[195]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]

Drug(s) Affected By Apolipoprotein A-II (APOA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[196]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[196]
Atenolol	DMNKG1Z	Angina pectoris	BA40	Approved	[189]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[196]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[29]
Nifedipine	DMSVOZT	Angina pectoris	BA40	Approved	[197]

Drug(s) Affected By Apolipoprotein C-II (APOC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[29]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[89]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[23]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[198]

Drug(s) Affected By Apolipoprotein C-III (APOC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[199]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[50]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[199]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[199]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[200]
Allopurinol	DMLPAOB	Gout	FA25	Approved	[199]

Drug(s) Affected By C-reactive protein (CRP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lidocaine	DML4ZOT	Anaesthesia	9A78.6	Approved	[120]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[201]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[202]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[203]
Acalabrutinib	DM7GCVW	leukaemia	2A60-2B33	Approved	[204]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[205]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[206]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[207]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[67]
Milrinone	DM8TUPF	Congestive heart failure	BD10	Approved	[208]

Drug(s) Affected By Albumin (ALB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[41]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[120]
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[209]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[210]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[211]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[212]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[213]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[214]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[215]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[216]

Drug(s) Affected By 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[217]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[166]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[218]
Digoxin	DMQCTIH	Arrhythmia	BC9Z	Approved	[120]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[164]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[212]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[81]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[219]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]

Drug(s) Affected By Fructose-bisphosphate aldolase A (ALDOA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[220]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[221]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[222]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[167]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[223]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[224]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[225]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[225]

Drug(s) Affected By Apolipoprotein B-100 (APOB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[199]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[50]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[199]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[226]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[199]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[227]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[199]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[228]
Bendroflumethiazide	DM7EVLC	High blood pressure	BA00	Approved	[229]

Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[230]
Selenium	DM25CGV	N. A.	N. A.	Approved	[231]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[232]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[233]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[234]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[235]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[236]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[237]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[238]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[232]

Drug(s) Affected By Phosphatidylcholine-sterol acyltransferase (LCAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[146]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[188]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[239]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[29]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[240]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[240]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[41]

Drug(s) Affected By Thymidine kinase, cytosolic (TK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[241]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[242]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[164]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[243]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[77]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[238]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[244]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[245]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[45]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[45]

Drug(s) Affected By Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[146]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[246]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[247]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[220]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[224]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[248]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[249]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[62]

Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[250]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[251]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[252]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[253]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[254]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[255]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[256]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[257]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[258]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[259]

Drug(s) Affected By Fructose-bisphosphate aldolase B (ALDOB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[260]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[78]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[118]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[261]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[29]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[262]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[35]

Drug(s) Affected By Plasminogen activator inhibitor 1 (SERPINE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[263]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[264]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[265]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[266]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[267]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[268]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[58]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[269]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[44]

Drug(s) Affected By Cytochrome P450 1A2 (CYP1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zolmitriptan	DM1IB4Q	Migraine	8A80	Approved	[270]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[270]
Etoricoxib	DM6A4NW	Rheumatoid arthritis	FA20	Approved	[270]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[271]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[272]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[273]
Nifedipine	DMSVOZT	Angina pectoris	BA40	Approved	[274]
Zileuton	DMVRIC2	Allergic asthma	CA23.0	Approved	[275]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[276]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[120]

Drug(s) Affected By Cytochrome P450 2E1 (CYP2E1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fomepizole	DM6VOWQ	Athylene glycol or methanol poisoning	NE61	Approved	[277]
Ademetionine	DMYQDBO	Hepatic fibrosis	DB93.0	Approved	[278]
Theophylline	DMRJFN9	Bronchitis	CA20	Approved	[120]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[279]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[114]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[84]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[280]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Didanosine	DMI2QPE	Human immunodeficiency virus infection	1C62	Approved	[120]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[281]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[282]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[283]
Fructose	DM43AN2	Vomiting	MD90	Approved	[120]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[284]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[285]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[144]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[286]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[287]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[288]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[289]

Drug(s) Affected By Alpha-enolase (ENO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[290]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[220]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[221]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[222]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[16]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[125]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[291]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[292]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[225]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[293]

Drug(s) Affected By Histone H2B type 1-J (H2BC11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[47]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[53]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[294]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[29]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[39]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[41]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[63]
Berberine	DMC5Q8X	N. A.	N. A.	Phase 4	[295]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[296]

Drug(s) Affected By Protein disulfide-isomerase (P4HB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[199]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[220]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[199]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[297]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[199]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[125]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[199]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[142]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]

Drug(s) Affected By Apolipoprotein(a) (LPA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[298]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[29]
Vitamin B3	DMQVRZH	Chronic renal failure	GB61.Z	Approved	[299]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[23]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[300]

Drug(s) Affected By Monocyte differentiation antigen CD14 (CD14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[144]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[77]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[301]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[59]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[302]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[303]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[45]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[304]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[305]

Drug(s) Affected By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[306]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[307]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[308]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[309]
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[310]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[310]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[311]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[312]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[313]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[314]

Drug(s) Affected By Steroid 21-hydroxylase (CYP21A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[315]
Mitotane	DMU1GX0	Adrenocortical carcinoma	2D11.Z	Approved	[316]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[41]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[22]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[317]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[23]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[318]
Forskolin	DM6ITNG	Solid tumour/cancer	2A00-2F9Z	Investigative	[319]
3-MeSO2-DDE	DMAWEQH	Discovery agent	N.A.	Investigative	[320]

Drug(s) Affected By Interleukin-6 receptor subunit alpha (IL6R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[321]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[322]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[323]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[324]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[325]
Mebendazole	DMO14SG	Ascariasis	1F62	Approved	[323]

Drug(s) Affected By Proto-oncogene tyrosine-protein kinase ROS (ROS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[246]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[326]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[39]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[84]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[327]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[76]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[23]

Drug(s) Affected By 3-ketoacyl-CoA thiolase, peroxisomal (ACAA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[100]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[200]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[29]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[32]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[21]
Capecitabine	DMTS85L	Adenocarcinoma	2D40	Approved	[328]

Drug(s) Affected By Glutathione S-transferase P (GSTP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[329]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[39]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[330]
Chlorambucil	DMRKE63	Chronic lymphocytic leukaemia	2A82.0	Approved	[330]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[331]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[127]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[146]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[220]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[332]

Drug(s) Affected By Fructose-1,6-bisphosphatase 1 (FBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[333]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[194]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[100]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[334]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[128]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[29]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[335]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[336]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[337]

Drug(s) Affected By Inhibin beta B chain (INHBB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[164]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[116]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[95]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[47]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[69]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[29]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[39]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[164]

Drug(s) Affected By Fructose-bisphosphate aldolase C (ALDOC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[249]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[194]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[338]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[339]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[53]

Drug(s) Affected By Serum amyloid A-1 protein (SAA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[116]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[45]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[45]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[75]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[69]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[340]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[262]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[341]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[342]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[343]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[344]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[345]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[346]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[120]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[347]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[348]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[349]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[350]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[351]

Drug(s) Affected By Transforming growth factor beta-3 proprotein (TGFB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[176]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[34]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[50]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[116]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[292]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[45]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[352]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]

Drug(s) Affected By Cytochrome P450 2C8 (CYP2C8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[353]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[354]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[353]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[354]
Sulfinpyrazone	DMEV954	Gout	FA25	Approved	[355]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[353]
Zafirlukast	DMHNQOG	Asthma	CA23	Approved	[353]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[353]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[356]
Dabrafenib	DMX6OE3	Melanoma	2C30	Approved	[357]

Drug(s) Affected By Cytochrome P450 2D6 (CYP2D6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[358]
Paliperidone	DM7NPJS	Psychotic disorder	6A20-6A25	Approved	[359]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[360]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[361]
Oxatomide	DM1F42Z	Hay fever	CA08.00	Approved	[362]
Cinacalcet	DMCX0K3	Hyperparathyroidism	5A51	Approved	[363]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[271]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[310]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[364]
Buprenorphine	DMPRI8G	Opioid dependence	6C43.2Z	Approved	[365]

Drug(s) Affected By Hepatic triacylglycerol lipase (LIPC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[100]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[366]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[29]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[40]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[84]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[367]

Drug(s) Affected By Pyruvate carboxylase, mitochondrial (PC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[194]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[60]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[261]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[61]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[63]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[85]

Drug(s) Affected By Cytochrome P450 2A6 (CYP2A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tegafur	DM31ZQM	Solid tumour/cancer	2A00-2F9Z	Approved	[368]
Methoxsalen	DME8FZ9	Cutaneous T-cell lymphoma	2B01	Approved	[369]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[370]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[371]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[84]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[372]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[373]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[374]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[375]

Drug(s) Affected By Aromatase (CYP19A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[376]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[377]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[378]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[34]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[378]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[80]
FADROZOLE	DM3C5GZ	Breast cancer	2C60-2C65	Approved	[379]
Bifonazole	DM3KN7V	Fungal infection	1F29-1F2F	Approved	[380]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[381]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[378]

Drug(s) Affected By Cytochrome P450 2C9 (CYP2C9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[307]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[382]
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[310]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[309]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[271]
Zafirlukast	DMHNQOG	Asthma	CA23	Approved	[383]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[310]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[384]
Fluconazole	DMOWZ6B	Cryptococcal meningitis		Approved	[309]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[310]

Drug(s) Affected By Beta-enolase (ENO3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[385]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[72]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[249]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[261]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[61]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[29]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[240]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[240]

Drug(s) Affected By Farnesyl pyrophosphate synthase (FDPS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[386]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[100]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[387]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[101]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[29]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[32]

Drug(s) Affected By 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 (PFKFB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[78]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[41]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[35]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[388]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[22]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[35]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[24]

Drug(s) Affected By Protein kinase C alpha type (PRKCA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[389]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[390]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[224]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[47]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[391]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[61]

Drug(s) Affected By Transcription factor JunB (JUNB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[285]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[34]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[50]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[142]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[44]
Nilotinib	DM7HXWT	Chronic myelogenous leukaemia	2A20.0	Approved	[392]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[393]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[47]

Drug(s) Affected By Glutathione peroxidase 2 (GPX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[127]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[164]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[110]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[394]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[395]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[58]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[396]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[45]

Drug(s) Affected By Syndecan-1 (SDC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[194]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[334]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[128]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[397]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[75]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[398]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[399]

Drug(s) Affected By Retinoic acid receptor RXR-alpha (RXRA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[400]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[50]
Selenium	DM25CGV	N. A.	N. A.	Approved	[401]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[402]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[403]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[404]
Acitretin	DM8BKU9	Psoriasis vulgaris	EA90	Approved	[405]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[225]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[406]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[225]

Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[407]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[408]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[144]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[409]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[146]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[410]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[411]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[246]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[412]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[413]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[409]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[414]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[152]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[415]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[416]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[416]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[397]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[417]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[62]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[75]

Drug(s) Affected By Cytochrome P450 3A5 (CYP3A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[306]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[307]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[312]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[312]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[418]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[419]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[420]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[421]

Drug(s) Affected By Phosphatidylcholine translocator ABCB4 (ABCB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[422]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[423]
Methysergide	DM1EF73	Migraine	8A80	Approved	[424]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[110]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[385]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[424]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[425]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[115]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[16]

Drug(s) Affected By Glycerol-3-phosphate dehydrogenase , cytoplasmic (GPD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[67]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[69]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[41]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[35]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[22]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[426]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[426]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[426]

Drug(s) Affected By Glutathione peroxidase 3 (GPX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[127]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[100]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[67]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[427]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[428]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[429]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[430]

Drug(s) Affected By Fibroblast growth factor receptor 4 (FGFR4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[431]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[432]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[67]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[397]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[75]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[93]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[29]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[39]

Drug(s) Affected By Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[57]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[433]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[100]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[47]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[78]

Drug(s) Affected By Cytochrome P450 3A7 (CYP3A7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[419]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[434]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[435]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[436]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[437]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[438]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[439]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[440]

Drug(s) Affected By Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[441]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[390]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[116]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[58]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[442]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[443]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[67]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[339]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[444]

Drug(s) Affected By Peroxiredoxin-6 (PRDX6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[445]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[446]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[447]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[448]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[69]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[449]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[33]

Drug(s) Affected By Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (PPP2R1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[67]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[29]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[30]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[98]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[30]

Drug(s) Affected By Glutathione S-transferase theta-1 (GSTT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[450]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[142]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[30]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[40]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[84]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[451]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[452]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[30]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[453]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[454]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[455]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[351]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[456]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[457]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[458]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[212]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[154]

Drug(s) Affected By RAC-beta serine/threonine-protein kinase (AKT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[212]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[459]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[460]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[459]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[461]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[62]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[462]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[463]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[30]

Drug(s) Affected By 14-3-3 protein sigma (SFN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[464]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[409]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[179]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[55]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[333]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[55]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[465]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[466]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[225]

Drug(s) Affected By Glycerol kinase (GK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[100]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[396]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[78]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[467]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[29]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[468]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[469]

Drug(s) Affected By Long-chain-fatty-acid--CoA ligase 1 (ACSL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[66]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[50]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[16]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[470]
Tolcapone	DM8MNVO	Parkinson disease	8A00.0	Approved	[471]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[225]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[225]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[225]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]

Drug(s) Affected By Protein S100-A3 (S100A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[66]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[46]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[75]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[61]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[29]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[472]

Drug(s) Affected By Phosphoenolpyruvate carboxykinase, cytosolic (PCK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[50]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[80]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[473]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[474]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[475]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[476]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[47]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]

Drug(s) Affected By Insulin-like growth factor-binding protein complex acid labile subunit (IGFALS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[62]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[477]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[478]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[29]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[478]
Cenestin	DMXQS7K	Menopause symptom	GA30.0	Approved	[478]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[479]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[22]

Drug(s) Affected By Phosphoglucomutase-1 (PGM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[16]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[100]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[142]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[200]

Drug(s) Affected By TGF-beta receptor type-1 (TGFBR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[25]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[176]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[480]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[481]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[416]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[416]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[67]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[482]

Drug(s) Affected By Sterol regulatory element-binding protein 1 (SREBF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[77]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[120]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[177]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[483]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[110]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[484]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[108]
Vemurafenib	DM62UG5	Melanoma	2C30	Approved	[485]

Drug(s) Affected By Interleukin-6 receptor subunit beta (IL6ST)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[486]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[487]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[16]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[488]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[416]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[416]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[45]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[45]

Drug(s) Affected By Malate dehydrogenase, cytoplasmic (MDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[489]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[247]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[100]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[248]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[249]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[249]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[69]

Drug(s) Affected By Mitogen-activated protein kinase kinase kinase 8 (MAP3K8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[144]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[50]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[385]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[16]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[46]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[47]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]

Drug(s) Affected By 3-ketoacyl-CoA thiolase, mitochondrial (ACAA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[80]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[100]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[152]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[117]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[78]

Drug(s) Affected By ATP-binding cassette sub-family G member 1 (ABCG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[103]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[16]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[115]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[44]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[225]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[225]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[225]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[490]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[428]

Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[385]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[491]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[492]

Drug(s) Affected By Lanosterol synthase (LSS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[493]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[110]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[493]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[493]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[493]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[78]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[494]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[493]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[493]

Drug(s) Affected By Fatty acid synthase (FASN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[495]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[212]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[199]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[496]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[497]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[425]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[498]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[499]

Drug(s) Affected By Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[500]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[80]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[425]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[59]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[501]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[502]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[292]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[47]

Drug(s) Affected By Interleukin-1 receptor-associated kinase 1 (IRAK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[50]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[503]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[413]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[504]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[505]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[506]
Bortezomib	DMNO38U	Leukemia		Approved	[507]

Drug(s) Affected By Aldo-keto reductase family 1 member D1 (AKR1D1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[325]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[29]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[39]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[84]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[35]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[436]

Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 6 (MAP2K6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[50]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[508]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[77]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[16]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[509]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[352]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[491]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]

Drug(s) Affected By Tricarboxylate transport protein, mitochondrial (SLC25A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[249]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[510]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[511]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[61]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[69]

Drug(s) Affected By Diphosphomevalonate decarboxylase (MVD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[100]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[67]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[75]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[29]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[512]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[262]

Drug(s) Affected By Mitogen-activated protein kinase 12 (MAPK12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[513]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[514]
Sorbitol	DMAN0DE	Constipation	DD91.1	Approved	[515]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[516]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[517]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[43]
Amsacrine	DMZKYIV	Acute lymphoblastic leukaemia	2A85	Approved	[516]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[518]

Drug(s) Affected By Glycogen synthase, liver (GYS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[39]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[84]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[35]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[35]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[519]
P-Coumaric Acid	DMGJSVD	Discovery agent	N.A.	Investigative	[520]

Drug(s) Affected By Phospholipid transfer protein (PLTP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[179]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[16]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[100]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[334]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[128]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[39]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[40]

Drug(s) Affected By BH3-interacting domain death agonist (BID)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[486]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[521]
Selenium	DM25CGV	N. A.	N. A.	Approved	[522]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[413]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[194]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[523]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[524]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[525]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]

Drug(s) Affected By 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 (HSD17B7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[526]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[194]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[100]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[67]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[61]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[29]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[39]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[40]

Drug(s) Affected By Transforming growth factor beta-2 proprotein (TGFB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[527]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[528]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[529]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[45]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[352]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[46]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[75]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[134]

Drug(s) Affected By Ras-related protein R-Ras2 (RRAS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[530]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[531]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[532]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[533]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[61]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[69]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[534]

Drug(s) Affected By Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (PPP2CB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[164]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[385]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[142]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[261]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[29]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[164]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[535]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[40]

Drug(s) Affected By Metallothionein-1H (MT1H)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[536]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[164]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[125]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[338]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[37]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[537]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[69]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[538]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[539]

Drug(s) Affected By Basement membrane-specific heparan sulfate proteoglycan core protein (HSPG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[385]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[540]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[29]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[84]
Seocalcitol	DMKL9QO	Rickets	5B57	Phase 3	[541]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[542]

Drug(s) Affected By Nuclear factor NF-kappa-B p100 subunit (NFKB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[486]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[144]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[503]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[95]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[505]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]

Drug(s) Affected By Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[249]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[66]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[50]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[543]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[543]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[497]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[543]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[498]

Drug(s) Affected By Protein kinase C epsilon type (PRKCE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[544]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[77]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[194]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Indomethacin	DMSC4A7	Bursitis		Approved	[545]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[40]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[546]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[63]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[22]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[547]

Drug(s) Affected By Sterol 26-hydroxylase, mitochondrial (CYP27A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[110]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[102]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[42]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[548]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[67]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[128]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[549]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[192]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]

Drug(s) Affected By DNA-binding protein inhibitor ID-2 (ID2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[489]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[550]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[551]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[490]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[125]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[152]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[550]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[44]

Drug(s) Affected By Cytochrome P450 4A11 (CYP4A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[552]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[553]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[553]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[42]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[553]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[553]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[553]
Oxaprozin	DM9UB0P	Osteoarthritis	FA00-FA05	Approved	[553]

Drug(s) Affected By Mevalonate kinase (MVK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[110]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[81]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[100]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[467]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[69]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[29]

Drug(s) Affected By Peroxiredoxin-1 (PRDX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[554]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[220]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[503]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[255]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[555]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[142]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[556]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[555]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[248]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]

Drug(s) Affected By Cytochrome P450 4F3 (CYP4F3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[557]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[100]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[37]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[29]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[39]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[21]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[435]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[558]

Drug(s) Affected By Adenylate cyclase type 1 (ADCY1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Reserpine	DM6VM38	Hypertension	BA00-BA04	Approved	[120]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[194]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[225]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[225]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[225]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[225]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[559]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[39]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[452]

Drug(s) Affected By Sterol regulatory element-binding protein 2 (SREBF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[120]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[560]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[194]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[498]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[44]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[561]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[496]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[496]

Drug(s) Affected By Dihydropyrimidine dehydrogenase (DPYD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[562]
Capecitabine	DMTS85L	Adenocarcinoma	2D40	Approved	[563]
Tegafur	DM31ZQM	Solid tumour/cancer	2A00-2F9Z	Approved	[564]
Flucytosine	DM13VTW	Cryptococcal meningitis		Approved	[120]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]

Drug(s) Affected By TNF receptor-associated factor 2 (TRAF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[565]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[413]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[269]
Ceritinib	DMB920Z	Non-small-cell lung cancer	2C25.Y	Approved	[566]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[62]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[567]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[29]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[39]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[21]

Drug(s) Affected By Protein AF1q (MLLT11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[55]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[568]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[68]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[75]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[61]
Bortezomib	DMNO38U	Leukemia		Approved	[467]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[86]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[29]

Drug(s) Affected By Acetyl-CoA carboxylase 1 (ACACA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[569]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[570]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[199]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[540]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[194]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[498]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[499]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[100]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[571]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[501]

Drug(s) Affected By FAS-associated death domain protein (FADD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[347]
Selenium	DM25CGV	N. A.	N. A.	Approved	[572]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[246]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[573]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[125]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[574]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[556]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[44]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[575]
Acitretin	DM8BKU9	Psoriasis vulgaris	EA90	Approved	[576]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 3 (BIRC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[577]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[578]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[66]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[521]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[503]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[194]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[490]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[579]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[580]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[396]

Drug(s) Affected By Isopentenyl-diphosphate Delta-isomerase 1 (IDI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[497]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[490]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[100]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[47]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[249]

Drug(s) Affected By Phosphatidate phosphatase LPIN1 (LPIN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[81]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[100]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[581]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[467]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[61]

Drug(s) Affected By Delta(14)-sterol reductase LBR (LBR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[164]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[45]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[45]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[47]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[68]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[69]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[29]

Drug(s) Affected By Caspase-8 (CASP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[582]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[583]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[584]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[486]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[585]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[586]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[521]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[587]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[80]

Drug(s) Affected By Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[67]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[200]
Ciprofibrate	DMGC5DB	Hyperlipoproteinemia	5C80	Approved	[588]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[589]
Sodium Acetate Anhydrous	DMH21E0	Hyponatraemia	5C72	Approved	[590]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[366]

Drug(s) Affected By Ribosomal protein S6 kinase alpha-2 (RPS6KA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[66]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[396]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[591]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[592]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[539]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[240]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[39]

Drug(s) Affected By Transcription elongation factor A protein 2 (TCEA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[385]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[46]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[29]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[240]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[240]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[40]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[21]

Drug(s) Affected By TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (TAB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[63]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[22]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[23]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[65]
Manganese	DMKT129	N. A.	N. A.	Investigative	[593]

Drug(s) Affected By Mitogen-activated protein kinase 11 (MAPK11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[503]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[594]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[595]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[45]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[39]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[596]

Drug(s) Affected By Methylsterol monooxygenase 1 (MSMO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[50]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[167]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[100]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[167]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[67]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[45]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[47]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]

Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[513]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[597]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[144]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[598]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[599]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[600]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[233]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[601]

Drug(s) Affected By Dual specificity protein phosphatase 6 (DUSP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[347]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[50]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[602]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[396]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[82]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[47]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[37]

Drug(s) Affected By Lanosterol 14-alpha demethylase (CYP51A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[570]
FADROZOLE	DM3C5GZ	Breast cancer	2C60-2C65	Approved	[603]
Bifonazole	DM3KN7V	Fungal infection	1F29-1F2F	Approved	[603]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[100]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[292]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[67]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[47]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]

Drug(s) Affected By Meteorin-like protein (METRNL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[66]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[50]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[46]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[75]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[93]

Drug(s) Affected By Cyclic AMP-responsive element-binding protein 3-like protein 3 (CREB3L3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[50]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[47]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[78]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[72]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[29]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[41]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[35]

Drug(s) Affected By Single Ig IL-1-related receptor (SIGIRR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[39]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[84]
Diphenylpyraline	DMW4X37	Allergic rhinitis	CA08.0	Approved	[604]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[68]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[85]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[96]

Drug(s) Affected By Ultra-long-chain fatty acid omega-hydroxylase (CYP4F22)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[128]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[240]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[240]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[84]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[605]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[23]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[606]

Drug(s) Affected By Vitamin D 25-hydroxylase (CYP2R1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[61]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[477]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[50]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[22]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[76]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[606]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[36]

Drug(s) Affected By SUZ domain-containing protein 1 (SZRD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[29]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[88]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[21]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[85]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[27]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[23]

Drug(s) Affected By Cytochrome P450 2U1 (CYP2U1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[607]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[45]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[428]
Bortezomib	DMNO38U	Leukemia		Approved	[467]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[608]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[41]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[63]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[20]

Drug(s) Affected By Tubulin epsilon and delta complex protein 1 (TEDC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[61]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[29]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[32]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[22]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[609]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[24]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[610]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[611]

Drug(s) Affected By ADAMTS-like protein 2 (ADAMTSL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[194]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[40]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[63]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[612]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[23]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[24]

Drug(s) Affected By 60 kDa lysophospholipase (ASPG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[41]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[613]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[66]

Drug(s) Affected By Organic solute transporter subunit alpha (SLC51A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[50]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[110]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[385]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[111]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[614]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[111]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[46]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[47]

Drug(s) Affected By Organic solute transporter subunit beta (SLC51B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[615]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[50]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[111]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[614]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[476]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[111]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[616]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[47]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]

Drug(s) Affected By Na(+)/citrate cotransporter (SLC13A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[511]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[617]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[67]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[29]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[240]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[41]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[479]

Drug(s) Affected By Leucine-rich repeat LGI family member 4 (LGI4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[21]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[479]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[24]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[66]

Drug(s) Affected By Neuropeptide W (NPW)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[68]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[605]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[618]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[23]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[619]

Drug(s) Affected By Sodium-dependent lysophosphatidylcholine symporter 1 (MFSD2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[66]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[44]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[46]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[620]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[78]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[78]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[621]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[29]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[84]

Drug(s) Affected By Mixed lineage kinase domain-like protein (MLKL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[58]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[622]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[623]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[78]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[325]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[29]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[240]

Drug(s) Affected By Scavenger receptor class B member 1 (SCARB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[624]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[625]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[626]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[194]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[107]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[109]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[561]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[627]

Drug(s) Affected By Phosphatidate phosphatase LPIN2 (LPIN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[66]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[32]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[41]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[63]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[68]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[628]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[609]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[24]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[65]

Drug(s) Affected By Caspase-10 (CASP10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[66]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[570]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[521]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[385]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[629]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[255]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[630]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[67]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]

Drug(s) Affected By Bcl2-associated agonist of cell death (BAD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[631]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[578]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[486]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[632]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[633]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[634]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[635]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[269]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[443]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[556]

Drug(s) Affected By Cyclic AMP-responsive element-binding protein 3-like protein 1 (CREB3L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[45]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[128]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[605]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[63]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[23]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[24]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[636]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[637]

Drug(s) Affected By Diacylglycerol O-acyltransferase 2 (DGAT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[483]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[80]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[194]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[67]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[46]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[638]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[69]

Drug(s) Affected By Leukocyte receptor cluster member 8 (LENG8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[32]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[40]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[63]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[22]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[23]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[24]

Drug(s) Affected By Cytochrome P450 2S1 (CYP2S1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[639]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[45]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[46]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[640]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[641]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[641]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[325]

Drug(s) Affected By Peroxisomal acyl-coenzyme A oxidase 2 (ACOX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[100]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[45]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[29]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[240]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[240]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[262]

Drug(s) Affected By Mitogen-activated protein kinase kinase kinase 14 (MAP3K14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[503]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[565]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[194]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[45]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[45]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[47]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[397]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[62]

Drug(s) Affected By Mitogen-activated protein kinase kinase kinase 5 (MAP3K5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[642]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[16]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[643]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[644]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[491]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[61]
Levodopa	DMN3E57	Parkinson disease	8A00.0	Approved	[645]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[399]

Drug(s) Affected By Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial (ECSIT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[39]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[26]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[96]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[23]

Drug(s) Affected By Receptor-transporting protein 3 (RTP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[47]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[609]

Drug(s) Affected By Very long chain fatty acid elongase 1 (ELOVL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[100]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[646]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[21]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[647]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[648]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[618]

Drug(s) Affected By Protein amnionless (AMN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[385]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[649]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[19]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[84]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[23]

Drug(s) Affected By Forkhead box protein P3 (FOXP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[66]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[650]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[651]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[652]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[477]
GSK618334	DMJPXZ4	Drug abuse	6C4G.1Z	Phase 1	[653]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[23]
Dorsomorphin	DMKYXJW	Discovery agent	N.A.	Investigative	[654]
Mepacrine	DMU8L7C	Discovery agent	N.A.	Investigative	[655]

Drug(s) Affected By 3 beta-hydroxysteroid dehydrogenase type 7 (HSD3B7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[41]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[63]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[22]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[609]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[24]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[656]

Drug(s) Affected By Lck-interacting transmembrane adapter 1 (LIME1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[640]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[22]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[96]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[657]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[24]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[65]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[198]

Drug(s) Affected By Very long chain fatty acid elongase 6 (ELOVL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[75]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[134]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[69]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[658]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[29]

Drug(s) Affected By Cytochrome P450 3A43 (CYP3A43)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[177]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[78]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[152]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[118]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[21]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[437]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[659]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[22]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[23]

Drug(s) Affected By Cytochrome P450 4F11 (CYP4F11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[660]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[142]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[128]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[661]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[61]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[660]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[325]

Drug(s) Affected By Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[570]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[80]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[67]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[53]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[662]

Drug(s) Affected By Cytochrome P450 4F12 (CYP4F12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[661]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[294]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[29]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[21]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[612]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[35]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[37]

Drug(s) Affected By Solute carrier organic anion transporter family member 1B3 (SLCO1B3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Warfarin	DMJYCVW	Atrial fibrillation	BC81.3	Approved	[663]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[664]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[665]
Trospium chloride	DM32XZT	Discovery agent	N.A.	Approved	[666]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[111]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[614]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[111]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[46]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[667]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]

Drug(s) Affected By 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon (AGPAT5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[509]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[47]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[75]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[29]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[99]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[605]

Drug(s) Affected By Very long chain fatty acid elongase 2 (ELOVL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[509]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[29]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[30]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[21]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[611]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[63]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[85]

Drug(s) Affected By 24-hydroxycholesterol 7-alpha-hydroxylase (CYP39A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[66]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[16]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[152]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[239]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[262]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[85]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[437]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[85]

Drug(s) Affected By Very-long-chain enoyl-CoA reductase (TECR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[100]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[568]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[61]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[40]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[63]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[24]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[198]

Drug(s) Affected By C5a anaphylatoxin chemotactic receptor 2 (C5AR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[605]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[23]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[66]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[606]

Drug(s) Affected By 7-dehydrocholesterol reductase (DHCR7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[668]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[194]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[100]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[125]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[292]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[128]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[47]

Drug(s) Affected By DnaJ homolog subfamily B member 11 (DNAJB11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Haloperidol	DM96SE0	Delirium		Approved	[249]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[249]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[249]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[669]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[63]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[337]

Drug(s) Affected By Mitochondrial dicarboxylate carrier (SLC25A10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[77]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[194]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[511]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[39]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[99]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[22]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[670]

Drug(s) Affected By Cysteine-rich C-terminal protein 1 (CRCT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[396]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[19]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[294]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[671]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[558]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[23]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[606]

Drug(s) Affected By Fetuin-B (FETUB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[29]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[671]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[21]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[35]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[22]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[35]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[66]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[606]

Drug(s) Affected By Polypyrimidine tract-binding protein 2 (PTBP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[67]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[60]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[61]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[70]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[39]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[63]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[672]

Drug(s) Affected By Long-chain-fatty-acid--CoA ligase 6 (ACSL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[80]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[29]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[262]
Methamphetamine	DMPM4SK	Anxiety		Approved	[673]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[22]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[674]
methyl p-hydroxybenzoate	DMO58UW	Discovery agent	N.A.	Investigative	[675]

Drug(s) Affected By Long-chain-fatty-acid--CoA ligase 5 (ACSL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[100]
Tolcapone	DM8MNVO	Parkinson disease	8A00.0	Approved	[471]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[75]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[69]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[325]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[29]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[41]

Drug(s) Affected By Myocardin-related transcription factor B (MRTFB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[66]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[100]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[621]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[29]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[41]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[63]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[22]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[676]

Drug(s) Affected By Carbonic anhydrase 14 (CA14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[89]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[657]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[24]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[677]

Drug(s) Affected By Transcription factor MafF (MAFF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[127]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[34]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[50]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[678]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[77]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[16]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[100]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[58]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[509]

Drug(s) Affected By 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase (CYP8B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Chenodiol	DMQ8JIK	Cholelithiasis	DC11	Approved	[111]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[110]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[111]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[111]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[549]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[40]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[679]

Drug(s) Affected By Protein phosphatase 1 regulatory subunit 3C (PPP1R3C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[536]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[530]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[385]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[238]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[67]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[78]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[134]

Drug(s) Affected By Long-chain fatty acid transport protein 5 (SLC27A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[614]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[60]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[29]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[680]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[84]
Berberine	DMC5Q8X	N. A.	N. A.	Phase 4	[681]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[35]

Drug(s) Affected By Acyl-coenzyme A thioesterase 9, mitochondrial (ACOT9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[59]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[67]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[29]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[68]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[20]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[23]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[24]

Drug(s) Affected By Chloride intracellular channel protein 4 (CLIC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[126]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[536]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[249]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[29]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[39]

Drug(s) Affected By Solute carrier organic anion transporter family member 1B1 (SLCO1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Enalapril	DMNFUZR	Congestive heart failure	BD10	Approved	[682]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[683]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[118]
Repaglinide	DM5SXUV	Diabetic complication	5A2Y	Approved	[684]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[685]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[686]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[687]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[687]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[665]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[688]

Drug(s) Affected By Bile salt export pump (ABCB11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[689]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[690]
Glipizide	DMZA5PQ	Diabetic complication	5A2Y	Approved	[690]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[118]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[689]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[690]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[424]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[689]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[691]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[689]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[692]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[693]
Fructose	DM43AN2	Vomiting	MD90	Approved	[120]
Ketoprofen	DMRKXPT	Bursitis		Approved	[120]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[694]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[350]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[695]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[696]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[697]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[698]

Drug(s) Affected By Cytochrome P450 7A1 (CYP7A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[699]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[110]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[385]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[700]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[255]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[112]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[58]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[701]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[700]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[702]

Drug(s) Affected By Hepatic sodium/bile acid cotransporter (SLC10A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[110]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[703]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[58]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[704]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[111]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[705]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[78]

Drug(s) Affected By Nuclear receptor subfamily 0 group B member 2 (NR0B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[699]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[493]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[34]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[530]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[110]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[493]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[494]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[626]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[493]

Drug(s) Affected By Protein arginine N-methyltransferase 1 (PRMT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[706]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[707]
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[708]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[142]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[249]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Farnesoid X-activated receptor (FXR)	TTS4UGC	NR1H4_HUMAN	Modulator	[1]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Bile acid-CoA thioesterase (BAAT) Main DME	DERA3OF	BAAT_HUMAN	Substrate	[3]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
1-acyl-sn-glycerol-3-phosphate acyltransferase beta (AGPAT2)	OT5I4Y9K	PLCB_HUMAN	Gene/Protein Processing	[4]
1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon (AGPAT5)	OTNY3VMD	PLCE_HUMAN	Gene/Protein Processing	[4]
14-3-3 protein sigma (SFN)	OTLJCZ1U	1433S_HUMAN	Gene/Protein Processing	[4]
24-hydroxycholesterol 7-alpha-hydroxylase (CYP39A1)	OTBAJT4I	CP39A_HUMAN	Gene/Protein Processing	[4]
3 beta-hydroxysteroid dehydrogenase type 7 (HSD3B7)	OT2Y9IW4	3BHS7_HUMAN	Gene/Protein Processing	[4]
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)	OTRT3F3U	HMDH_HUMAN	Gene/Protein Processing	[4]
3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 (HSD17B7)	OTV7VOV3	DHB7_HUMAN	Gene/Protein Processing	[4]
3-ketoacyl-CoA thiolase, mitochondrial (ACAA2)	OTGLVWOP	THIM_HUMAN	Gene/Protein Processing	[4]
3-ketoacyl-CoA thiolase, peroxisomal (ACAA1)	OTVKRET0	THIK_HUMAN	Gene/Protein Processing	[4]
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 (PFKFB1)	OTTHX4NB	F261_HUMAN	Gene/Protein Processing	[4]

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