Details of the Drug

General Information of Drug (ID: DMITSEH)

Drug Name

Isoetharine

Synonyms

Bronkosol; Dilabron; Etyprenaline; Etyprenalinum; Isoetarin; Isoetarina; Isoetarine; Isoetarinum; Neoisuprel; Isoetharine Hcl; Win 3406; Bronkometer (TN); Bronkosol (TN); Dey-Lute Isoetharine; Isoetarina [INN-Spanish]; Isoetarine (INN); Isoetarinum [INN-Latin]; Isoetharine (USP); Isoetharine HCl S/F; Isoetharine [USAN:BAN]; 3,4-Dihydroxy-alpha-(1-(isopropylamino)propyl)benzyl alcohol; 4-[1-hydroxy-2-(propan-2-ylamino)butyl]benzene-1,2-diol

Indication

Disease Entry	ICD 11	Status	REF
Asthma	CA23	Approved	[1], [2]

Therapeutic Class

Bronchodilator Agents

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

#Ro5 Violations (Lipinski): 0

Molecular Weight (mw)

239.31

Topological Polar Surface Area (xlogp)

1.7

Rotatable Bond Count (rotbonds)

Hydrogen Bond Donor Count (hbonddonor)

Hydrogen Bond Acceptor Count (hbondacc)

Chemical Identifiers

Formula: C13H21NO3
IUPAC Name: 4-[1-hydroxy-2-(propan-2-ylamino)butyl]benzene-1,2-diol
Canonical SMILES: CCC(C(C1=CC(=C(C=C1)O)O)O)NC(C)C
InChI: InChI=1S/C13H21NO3/c1-4-10(14-8(2)3)13(17)9-5-6-11(15)12(16)7-9/h5-8,10,13-17H,4H2,1-3H3
InChIKey: HUYWAWARQUIQLE-UHFFFAOYSA-N

Cross-matching ID

PubChem CID: 3762
ChEBI ID: CHEBI:6005
CAS Number: 530-08-5
DrugBank ID: DB00221
TTD ID: D08HUC

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adrenergic receptor beta-2 (ADRB2)	TT2CJVK	ADRB2_HUMAN	Modulator	[3]

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Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease

Asthma

ICD Disease Classification

CA23

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Adrenergic receptor beta-2 (ADRB2)	DTT	ADRB2	4.88E-01	-0.05	-0.12
Adrenergic receptor beta-2 (ADRB2)	DTT	ADRB2	7.10E-01	0.06	0.09

Molecular Expression Atlas (MEA)

MEA Detail

Jump to Detail Molecular Expression Atlas of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Same Disease as Isoetharine

DDI Drug Name	DDI Drug ID	Severity	Mechanism	Disease	REF
Budesonide	DMJIBAW	Minor	Increased risk of hypokalemia by the combination of Isoetharine and Budesonide.	Asthma [CA23]	[13]
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Coadministration of a Drug Treating the Disease Different from Isoetharine (Comorbidity)

DDI Drug Name	DDI Drug ID	Severity	Mechanism	Comorbidity	REF
Methylene blue	DMJAPE7	Moderate	Additive hypertensive effects by the combination of Isoetharine and Methylene blue.	Acquired methaemoglobinaemia [3A93]	[14]
Ivosidenib	DM8S6T7	Moderate	Increased risk of prolong QT interval by the combination of Isoetharine and Ivosidenib.	Acute myeloid leukaemia [2A60]	[15]
Midostaurin	DMI6E0R	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Midostaurin.	Acute myeloid leukaemia [2A60]	[15]
Idarubicin	DMM0XGL	Moderate	Increased risk of prolong QT interval by the combination of Isoetharine and Idarubicin.	Acute myeloid leukaemia [2A60]	[15]
Daunorubicin	DMQUSBT	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Daunorubicin.	Acute myeloid leukaemia [2A60]	[15]
Arn-509	DMT81LZ	Moderate	Increased risk of prolong QT interval by the combination of Isoetharine and Arn-509.	Acute myeloid leukaemia [2A60]	[15]
Gilteritinib	DMWQ4MZ	Moderate	Increased risk of prolong QT interval by the combination of Isoetharine and Gilteritinib.	Acute myeloid leukaemia [2A60]	[15]
Oliceridine	DM6MDCF	Moderate	Increased risk of prolong QT interval by the combination of Isoetharine and Oliceridine.	Acute pain [MG31]	[16]
Ranolazine	DM0C9IL	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Ranolazine.	Angina pectoris [BA40]	[15]
Ivabradine	DM0L594	Moderate	Increased risk of prolong QT interval by the combination of Isoetharine and Ivabradine.	Angina pectoris [BA40]	[15]
Dronedarone	DMA8FS5	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Dronedarone.	Angina pectoris [BA40]	[15]
Hydroxyzine	DMF8Y74	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Hydroxyzine.	Anxiety disorder [6B00-6B0Z]	[15]
Cilostazol	DMZMSCT	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Cilostazol.	Arterial occlusive disease [BD40]	[15]
Voriconazole	DMAOL2S	Moderate	Increased risk of prolong QT interval by the combination of Isoetharine and Voriconazole.	Aspergillosis [1F20]	[15]
Posaconazole	DMUL5EW	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Posaconazole.	Aspergillosis [1F20]	[15]
Lisdexamfetamine	DM6W8V5	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Lisdexamfetamine.	Attention deficit hyperactivity disorder [6A05]	[15]
Droxidopa	DM5YF4M	Moderate	Additive hypertensive effects by the combination of Isoetharine and Droxidopa.	Autonomic nervous system disorder [8D87]	[17]
Ofloxacin	DM0VQN3	Moderate	Increased risk of prolong QT interval by the combination of Isoetharine and Ofloxacin.	Bacterial infection [1A00-1C4Z]	[15]
Ciprofloxacin XR	DM2NLS9	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Ciprofloxacin XR.	Bacterial infection [1A00-1C4Z]	[15]
Clarithromycin	DM4M1SG	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Clarithromycin.	Bacterial infection [1A00-1C4Z]	[15]
Linezolid	DMGFPU2	Moderate	Additive hypertensive effects by the combination of Isoetharine and Linezolid.	Bacterial infection [1A00-1C4Z]	[14]
Gemifloxacin	DMHT34O	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Gemifloxacin.	Bacterial infection [1A00-1C4Z]	[15]
Norfloxacin	DMIZ6W2	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Norfloxacin.	Bacterial infection [1A00-1C4Z]	[16]
Levofloxacin	DMS60RB	Moderate	Increased risk of prolong QT interval by the combination of Isoetharine and Levofloxacin.	Bacterial infection [1A00-1C4Z]	[15]
Telithromycin	DMZ4P3A	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Telithromycin.	Bacterial infection [1A00-1C4Z]	[16]
Retigabine	DMGNYIH	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Retigabine.	Behcet disease [4A62]	[16]
Eribulin	DM1DX4Q	Moderate	Increased risk of prolong QT interval by the combination of Isoetharine and Eribulin.	Breast cancer [2C60-2C6Y]	[15]
Lapatinib	DM3BH1Y	Moderate	Increased risk of prolong QT interval by the combination of Isoetharine and Lapatinib.	Breast cancer [2C60-2C6Y]	[15]
Tamoxifen	DMLB0EZ	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Tamoxifen.	Breast cancer [2C60-2C6Y]	[15]
Toremifene	DMQYUWG	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Toremifene.	Breast cancer [2C60-2C6Y]	[15]
Bosutinib	DMTI8YE	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Bosutinib.	Breast cancer [2C60-2C6Y]	[15]
Corticotropin	DMP9TWZ	Minor	Increased risk of hypokalemia by the combination of Isoetharine and Corticotropin.	Chronic kidney disease [GB61]	[13]
PF-04449913	DMSB068	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and PF-04449913.	Chronic myelomonocytic leukaemia [2A40]	[15]
Levomilnacipran	DMV26S8	Moderate	Increased risk of rapid heart rate by the combination of Isoetharine and Levomilnacipran.	Chronic pain [MG30]	[18]
Oxaliplatin	DMQNWRD	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Oxaliplatin.	Colorectal cancer [2B91]	[15]
Halothane	DM80OZ5	Moderate	Increased risk of prolong QT interval by the combination of Isoetharine and Halothane.	Corneal disease [9A76-9A78]	[15]
Propofol	DMB4OLE	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Propofol.	Corneal disease [9A76-9A78]	[15]
Sevoflurane	DMC9O43	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Sevoflurane.	Corneal disease [9A76-9A78]	[15]
Methadone	DMTW6IU	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Methadone.	Cough [MD12]	[15]
Clofazimine	DMEBOFW	Moderate	Increased risk of prolong QT interval by the combination of Isoetharine and Clofazimine.	Crohn disease [DD70]	[16]
Mifepristone	DMGZQEF	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Mifepristone.	Cushing syndrome [5A70]	[15]
Pasireotide	DMHM7JS	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Pasireotide.	Cushing syndrome [5A70]	[15]
Osilodrostat	DMIJC9X	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Osilodrostat.	Cushing syndrome [5A70]	[16]
Sertraline	DM0FB1J	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Sertraline.	Depression [6A70-6A7Z]	[15]
Fluoxetine	DM3PD2C	Moderate	Increased risk of prolong QT interval by the combination of Isoetharine and Fluoxetine.	Depression [6A70-6A7Z]	[15]
Selegiline	DM6034S	Moderate	Additive hypertensive effects by the combination of Isoetharine and Selegiline.	Depression [6A70-6A7Z]	[14]
Duloxetine	DM9BI7M	Moderate	Increased risk of rapid heart rate by the combination of Isoetharine and Duloxetine.	Depression [6A70-6A7Z]	[18]
Isocarboxazid	DMAF1NB	Moderate	Additive hypertensive effects by the combination of Isoetharine and Isocarboxazid.	Depression [6A70-6A7Z]	[14]
Milnacipran	DMBFE74	Moderate	Increased risk of rapid heart rate by the combination of Isoetharine and Milnacipran.	Depression [6A70-6A7Z]	[18]
Escitalopram	DMFK9HG	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Escitalopram.	Depression [6A70-6A7Z]	[15]
Tranylcypromine	DMGB5RE	Moderate	Additive hypertensive effects by the combination of Isoetharine and Tranylcypromine.	Depression [6A70-6A7Z]	[19]
Desvenlafaxine	DMHD4PE	Moderate	Additive hypertensive effects by the combination of Isoetharine and Desvenlafaxine.	Depression [6A70-6A7Z]	[18]
Phenelzine	DMHIDUE	Moderate	Additive hypertensive effects by the combination of Isoetharine and Phenelzine.	Depression [6A70-6A7Z]	[14]
Trazodone	DMK1GBJ	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Trazodone.	Depression [6A70-6A7Z]	[15]
Mirtazapine	DML53ZJ	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Mirtazapine.	Depression [6A70-6A7Z]	[15]
Maprotiline	DMPWB7T	Moderate	Increased risk of prolong QT interval by the combination of Isoetharine and Maprotiline.	Depression [6A70-6A7Z]	[15]
Venlafaxine	DMR6QH0	Moderate	Increased risk of rapid heart rate by the combination of Isoetharine and Venlafaxine.	Depression [6A70-6A7Z]	[18]
Tetrabenazine	DMYWQ0O	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Tetrabenazine.	Dissociative neurological symptom disorder [6B60]	[15]
Deutetrabenazine	DMUPFLI	Moderate	Increased risk of prolong QT interval by the combination of Isoetharine and Deutetrabenazine.	Dystonic disorder [8A02]	[15]
Ingrezza	DMVPLNC	Moderate	Increased risk of prolong QT interval by the combination of Isoetharine and Ingrezza.	Dystonic disorder [8A02]	[15]
Solifenacin	DMG592Q	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Solifenacin.	Functional bladder disorder [GC50]	[15]
Pentamidine	DMHZJCG	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Pentamidine.	Fungal infection [1F29-1F2F]	[15]
Ketoconazole	DMPZI3Q	Moderate	Increased risk of prolong QT interval by the combination of Isoetharine and Ketoconazole.	Fungal infection [1F29-1F2F]	[15]
Sunitinib	DMCBJSR	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Sunitinib.	Gastrointestinal stromal tumour [2B5B]	[15]
Procarbazine	DMIK367	Moderate	Additive hypertensive effects by the combination of Isoetharine and Procarbazine.	Hodgkin lymphoma [2B30]	[14]
Fostemsavir	DM50ILT	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Fostemsavir.	Human immunodeficiency virus disease [1C60-1C62]	[15]
Efavirenz	DMC0GSJ	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Efavirenz.	Human immunodeficiency virus disease [1C60-1C62]	[15]
Saquinavir	DMG814N	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Saquinavir.	Human immunodeficiency virus disease [1C60-1C62]	[15]
Lopinavir	DMITQS0	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Lopinavir.	Human immunodeficiency virus disease [1C60-1C62]	[16]
Rilpivirine	DMJ0QOW	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Rilpivirine.	Human immunodeficiency virus disease [1C60-1C62]	[15]
Fludrocortisone	DMUDIR8	Minor	Increased risk of hypokalemia by the combination of Isoetharine and Fludrocortisone.	Hypo-osmolality/hyponatraemia [5C72]	[13]
Crizotinib	DM4F29C	Moderate	Increased risk of prolong QT interval by the combination of Isoetharine and Crizotinib.	Lung cancer [2C25]	[15]
Ceritinib	DMB920Z	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Ceritinib.	Lung cancer [2C25]	[15]
Osimertinib	DMRJLAT	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Osimertinib.	Lung cancer [2C25]	[15]
Selpercatinib	DMZR15V	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Selpercatinib.	Lung cancer [2C25]	[16]
Lumefantrine	DM29GAD	Moderate	Increased risk of prolong QT interval by the combination of Isoetharine and Lumefantrine.	Malaria [1F40-1F45]	[16]
Chloroquine	DMSI5CB	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Chloroquine.	Malaria [1F40-1F45]	[15]
Hydroxychloroquine	DMSIVND	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Hydroxychloroquine.	Malaria [1F40-1F45]	[15]
Quinine	DMSWYF5	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Quinine.	Malaria [1F40-1F45]	[15]
Primaquine	DMWQ16I	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Primaquine.	Malaria [1F40-1F45]	[15]
Mefloquine	DMWT905	Moderate	Increased risk of prolong QT interval by the combination of Isoetharine and Mefloquine.	Malaria [1F40-1F45]	[15]
Inotuzumab ozogamicin	DMAC130	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Inotuzumab ozogamicin.	Malignant haematopoietic neoplasm [2B33]	[15]
Arsenic trioxide	DM61TA4	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Arsenic trioxide.	Mature B-cell lymphoma [2A85]	[15]
Vemurafenib	DM62UG5	Moderate	Increased risk of prolong QT interval by the combination of Isoetharine and Vemurafenib.	Melanoma [2C30]	[15]
LGX818	DMNQXV8	Moderate	Increased risk of prolong QT interval by the combination of Isoetharine and LGX818.	Melanoma [2C30]	[15]
Panobinostat	DM58WKG	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Panobinostat.	Multiple myeloma [2A83]	[15]
Siponimod	DM2R86O	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Siponimod.	Multiple sclerosis [8A40]	[15]
Fingolimod	DM5JVAN	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Fingolimod.	Multiple sclerosis [8A40]	[15]
Ozanimod	DMT6AM2	Major	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Ozanimod.	Multiple sclerosis [8A40]	[20]
Romidepsin	DMT5GNL	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Romidepsin.	Mycosis fungoides [2B01]	[16]
Nilotinib	DM7HXWT	Moderate	Increased risk of prolong QT interval by the combination of Isoetharine and Nilotinib.	Myeloproliferative neoplasm [2A20]	[15]
Dasatinib	DMJV2EK	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Dasatinib.	Myeloproliferative neoplasm [2A20]	[15]
Droperidol	DM0DXA8	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Droperidol.	Nausea/vomiting [MD90]	[15]
Prochlorperazine	DM53SRA	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Prochlorperazine.	Nausea/vomiting [MD90]	[15]
Promethazine	DM6I5GR	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Promethazine.	Nausea/vomiting [MD90]	[15]
Palonosetron	DMBHMOX	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Palonosetron.	Nausea/vomiting [MD90]	[15]
Granisetron	DMIUW25	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Granisetron.	Nausea/vomiting [MD90]	[15]
Dolasetron	DMMG26Z	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Dolasetron.	Nausea/vomiting [MD90]	[15]
Ondansetron	DMOTQ1I	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Ondansetron.	Nausea/vomiting [MD90]	[15]
Entrectinib	DMMPTLH	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Entrectinib.	Non-small cell lung cancer [2C25]	[16]
Sibutramine	DMFJTDI	Moderate	Increased risk of rapid heart rate by the combination of Isoetharine and Sibutramine.	Obesity [5B80-5B81]	[21]
Lofexidine	DM1WXA6	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Lofexidine.	Opioid use disorder [6C43]	[15]
Rucaparib	DM9PVX8	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Rucaparib.	Ovarian cancer [2C73]	[15]
Dextropropoxyphene	DM23HCX	Moderate	Increased risk of prolong QT interval by the combination of Isoetharine and Dextropropoxyphene.	Pain [MG30-MG3Z]	[16]
Buprenorphine	DMPRI8G	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Buprenorphine.	Pain [MG30-MG3Z]	[15]
Triclabendazole	DMPWGBR	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Triclabendazole.	Parasitic worm infestation [1F90]	[16]
Safinamide	DM0YWJC	Moderate	Additive hypertensive effects by the combination of Isoetharine and Safinamide.	Parkinsonism [8A00]	[14]
Opicapone	DM1BKA6	Moderate	Decreased metabolism of Isoetharine caused by Opicapone mediated inhibition of non-CYP450 enzyme.	Parkinsonism [8A00]	[22]
Rasagiline	DM3WKQ4	Moderate	Additive hypertensive effects by the combination of Isoetharine and Rasagiline.	Parkinsonism [8A00]	[14]
Tolcapone	DM8MNVO	Moderate	Decreased metabolism of Isoetharine caused by Tolcapone mediated inhibition of non-CYP450 enzyme.	Parkinsonism [8A00]	[22]
Entacapone	DMLBVKQ	Moderate	Decreased metabolism of Isoetharine caused by Entacapone mediated inhibition of non-CYP450 enzyme.	Parkinsonism [8A00]	[22]
Pimavanserin	DMR7IVC	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Pimavanserin.	Parkinsonism [8A00]	[15]
Apomorphine	DMX38HQ	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Apomorphine.	Parkinsonism [8A00]	[15]
Famotidine	DMRL3AB	Moderate	Increased risk of prolong QT interval by the combination of Isoetharine and Famotidine.	Peptic ulcer [DA61]	[23]
Macimorelin	DMQYJIR	Major	Increased risk of prolong QT interval by the combination of Isoetharine and Macimorelin.	Pituitary gland disorder [5A60-5A61]	[24]
Lefamulin	DME6G97	Moderate	Increased risk of prolong QT interval by the combination of Isoetharine and Lefamulin.	Pneumonia [CA40]	[15]
Prednisone	DM2HG4X	Minor	Increased risk of hypokalemia by the combination of Isoetharine and Prednisone.	Postoperative inflammation [1A00-CA43]	[13]
Betamethasone	DMAHJEF	Minor	Increased risk of hypokalemia by the combination of Isoetharine and Betamethasone.	Postoperative inflammation [1A00-CA43]	[13]
Hydrocortisone	DMGEMB7	Minor	Increased risk of hypokalemia by the combination of Isoetharine and Hydrocortisone.	Postoperative inflammation [1A00-CA43]	[13]
Degarelix	DM3O8QY	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Degarelix.	Prostate cancer [2C82]	[15]
ABIRATERONE	DM8V75C	Moderate	Increased risk of prolong QT interval by the combination of Isoetharine and ABIRATERONE.	Prostate cancer [2C82]	[15]
Nilutamide	DMFN07X	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Nilutamide.	Prostate cancer [2C82]	[15]
Enzalutamide	DMGL19D	Moderate	Increased risk of prolong QT interval by the combination of Isoetharine and Enzalutamide.	Prostate cancer [2C82]	[15]
Flutamide	DMK0O7U	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Flutamide.	Prostate cancer [2C82]	[15]
Bicalutamide	DMZMSPF	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Bicalutamide.	Prostate cancer [2C82]	[15]
Alfuzosin	DMZVMKF	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Alfuzosin.	Prostate hyperplasia [GA90]	[15]
Fluphenazine	DMIT8LX	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Fluphenazine.	Psychotic disorder [6A20-6A25]	[15]
Sorafenib	DMS8IFC	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Sorafenib.	Renal cell carcinoma [2C90]	[15]
Gatifloxacin	DMSL679	Moderate	Increased risk of prolong QT interval by the combination of Isoetharine and Gatifloxacin.	Respiratory infection [CA07-CA4Z]	[16]
Ciclesonide	DM2NA4K	Minor	Increased risk of hypokalemia by the combination of Isoetharine and Ciclesonide.	Respiratory system disease [CB40-CB7Z]	[13]
Dexamethasone	DMMWZET	Minor	Increased risk of hypokalemia by the combination of Isoetharine and Dexamethasone.	Rheumatoid arthritis [FA20]	[13]
Quetiapine	DM1N62C	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Quetiapine.	Schizophrenia [6A20]	[15]
Mesoridazine	DM2ZGAN	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Mesoridazine.	Schizophrenia [6A20]	[16]
Thioridazine	DM35M8J	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Thioridazine.	Schizophrenia [6A20]	[16]
Aripiprazole	DM3NUMH	Moderate	Increased risk of prolong QT interval by the combination of Isoetharine and Aripiprazole.	Schizophrenia [6A20]	[23]
Iloperidone	DM6AUFY	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Iloperidone.	Schizophrenia [6A20]	[15]
Paliperidone	DM7NPJS	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Paliperidone.	Schizophrenia [6A20]	[15]
Haloperidol	DM96SE0	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Haloperidol.	Schizophrenia [6A20]	[15]
Perphenazine	DMA4MRX	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Perphenazine.	Schizophrenia [6A20]	[15]
Chlorpromazine	DMBGZI3	Moderate	Increased risk of prolong QT interval by the combination of Isoetharine and Chlorpromazine.	Schizophrenia [6A20]	[15]
Clozapine	DMFC71L	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Clozapine.	Schizophrenia [6A20]	[15]
Trifluoperazine	DMKBYWI	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Trifluoperazine.	Schizophrenia [6A20]	[15]
Ziprasidone	DMM58JY	Moderate	Increased risk of prolong QT interval by the combination of Isoetharine and Ziprasidone.	Schizophrenia [6A20]	[15]
Risperidone	DMN6DXL	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Risperidone.	Schizophrenia [6A20]	[15]
Olanzapine	DMPFN6Y	Moderate	Increased risk of prolong QT interval by the combination of Isoetharine and Olanzapine.	Schizophrenia [6A20]	[23]
Amisulpride	DMSJVAM	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Amisulpride.	Schizophrenia [6A20]	[15]
Asenapine	DMSQZE2	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Asenapine.	Schizophrenia [6A20]	[15]
Pimozide	DMW83TP	Moderate	Increased risk of prolong QT interval by the combination of Isoetharine and Pimozide.	Schizophrenia [6A20]	[15]
Vardenafil	DMTBGW8	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Vardenafil.	Sexual dysfunction [HA00-HA01]	[15]
Methylprednisolone	DM4BDON	Minor	Increased risk of hypokalemia by the combination of Isoetharine and Methylprednisolone.	Solid tumour/cancer [2A00-2F9Z]	[13]
LEE011	DMMX75K	Major	Increased risk of prolong QT interval by the combination of Isoetharine and LEE011.	Solid tumour/cancer [2A00-2F9Z]	[25]
Epirubicin	DMPDW6T	Moderate	Increased risk of prolong QT interval by the combination of Isoetharine and Epirubicin.	Solid tumour/cancer [2A00-2F9Z]	[15]
Prednisolone	DMQ8FR2	Minor	Increased risk of hypokalemia by the combination of Isoetharine and Prednisolone.	Solid tumour/cancer [2A00-2F9Z]	[13]
Vandetanib	DMRICNP	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Vandetanib.	Solid tumour/cancer [2A00-2F9Z]	[15]
Triptorelin	DMTK4LS	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Triptorelin.	Solid tumour/cancer [2A00-2F9Z]	[15]
Doxorubicin	DMVP5YE	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Doxorubicin.	Solid tumour/cancer [2A00-2F9Z]	[15]
Telavancin	DM58VQX	Moderate	Increased risk of prolong QT interval by the combination of Isoetharine and Telavancin.	Staphylococcal/streptococcal disease [1B5Y]	[15]
Ibutilide	DMKXY2R	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Ibutilide.	Supraventricular tachyarrhythmia [BC81]	[15]
Anagrelide	DMSQ8MD	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Anagrelide.	Thrombocytosis [3B63]	[15]
Lenvatinib	DMB1IU4	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Lenvatinib.	Thyroid cancer [2D10]	[15]
Tacrolimus	DMZ7XNQ	Moderate	Increased risk of ventricular arrhythmias by the combination of Isoetharine and Tacrolimus.	Transplant rejection [NE84]	[15]
Triamcinolone	DM98IXF	Minor	Increased risk of hypokalemia by the combination of Isoetharine and Triamcinolone.	Vasomotor/allergic rhinitis [CA08]	[13]
Fluticasone	DMGCSVF	Minor	Increased risk of hypokalemia by the combination of Isoetharine and Fluticasone.	Vasomotor/allergic rhinitis [CA08]	[13]
Disopyramide	DM5SYZP	Moderate	Increased risk of prolong QT interval by the combination of Isoetharine and Disopyramide.	Ventricular tachyarrhythmia [BC71]	[15]
Procainamide	DMNMXR8	Moderate	Increased risk of prolong QT interval by the combination of Isoetharine and Procainamide.	Ventricular tachyarrhythmia [BC71]	[15]
Propafenone	DMPIBJK	Moderate	Increased risk of prolong QT interval by the combination of Isoetharine and Propafenone.	Ventricular tachyarrhythmia [BC71]	[15]
Flecainide	DMSQDLE	Moderate	Increased risk of prolong QT interval by the combination of Isoetharine and Flecainide.	Ventricular tachyarrhythmia [BC71]	[15]
Amiodarone	DMUTEX3	Moderate	Increased risk of prolong QT interval by the combination of Isoetharine and Amiodarone.	Ventricular tachyarrhythmia [BC71]	[15]
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References

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