Details of the Drug-Related molecule(s) Interaction Atlas

Glyceryl trinitrate Drug Info

Gilustenon; Glycerol trinitrate; Glyceryl trinitrate; Lenitral; Minitran; Natispray; Nitro-Bid; Nitro-dur; Nitrocine; Nitroderm; Cordipatch; Corditrine; Epinitril; Nitroderm TTS; Nitroglicerina; Nitroglycerine; Nitroglycerol; Nitroglyn; Nitrolan; Nitrolingual; Nitronet; Nitrong; Nitroplast; Nitrorectal; Nitroretard; Nitrospan; Nitrostat; Perglottal; Perlinganit; Rectogesic; Susadrin; Sustonit; Transderm Nitro; Transderm-nitro; Tridil; Trinitrin; Trinitroglycerin; Trinitroglycerol; Trinitrolong; Trinitrosan; nitroglycerin; 55-63-0; Niong

Cross-matching ID

PubChem CID

4510

ChEBI ID

CHEMBL28787

CAS Number

CAS 55-63-0

TTD Drug ID

DMF72W3

INTEDE Drug ID

DR2513

General Information of Drug (ID: DMF72W3)

Molecule-Related Drug Atlas

Molecule Type:

DME

DOT

Drug Status:

Approved Drug(s)

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Drug(s) Affected By Aldehyde dehydrogenase, mitochondrial (ALDH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[11]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[12]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[13]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[14]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[15]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[16]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[18]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[19]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[20]
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Drug(s) Affected By Renin (REN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[21]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[22]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[23]
Reboxetine	DM26PRD	Depression	6A70-6A7Z	Approved	[24]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[25]
Ramipril	DM2R68E	Acute heart failure	BD10-BD13	Approved	[26]
Rhucin	DM3ADGP	Erectile dysfunction	HA01.1	Approved	[27]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[28]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[29]
Chlorthalidone	DM4DMBT	Edema	MG29	Approved	[30]
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Drug(s) Affected By Calcitonin (CALCA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[31]
Fructose	DM43AN2	Vomiting	MD90	Approved	[32]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[33]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[35]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[36]
Nizatidine	DMGFV3Z	Acid-reflux disorder	DA22	Approved	[31]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[37]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[39]
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Drug(s) Affected By Matrilysin (MMP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[40]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[43]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[47]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[48]
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Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[49]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[50]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[52]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[53]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[54]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[53]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[55]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[56]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]
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Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[58]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[59]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[60]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[61]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[62]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[63]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[64]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[65]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[66]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[64]
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Drug(s) Affected By Catenin beta-1 (CTNNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[67]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[68]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[69]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[70]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[72]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[73]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[74]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[75]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[76]
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Drug(s) Affected By Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 (GNB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[77]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[79]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[36]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[80]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[81]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[82]
Nortriptyline	DM4KDYJ	Depression	6A70-6A7Z	Approved	[83]
Sibutramine	DMFJTDI	Obesity	5B81	Approved	[84]
Almogran	DM7I64Z	Migraine	8A80	Approved	[85]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Microsomal glutathione S-transferase 1 (MGST1)^{Main DME}	DEAPJSO	MGST1_HUMAN	Substrate	[1]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Aldehyde dehydrogenase, mitochondrial (ALDH2)	OTKJ9I3N	ALDH2_HUMAN	Gene/Protein Processing	[2]
Calcitonin (CALCA)	OTZ11LHB	CALC_HUMAN	Gene/Protein Processing	[3]
Catenin beta-1 (CTNNB1)	OTZ932A3	CTNB1_HUMAN	Protein Interaction/Cellular Processes	[4]
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 (GNB3)	OTA6HYBA	GBB3_HUMAN	Drug Response	[5]
Interleukin-8 (CXCL8)	OTS7T5VH	IL8_HUMAN	Gene/Protein Processing	[6]
Matrilysin (MMP7)	OTVT3SEJ	MMP7_HUMAN	Gene/Protein Processing	[7]
Poly polymerase 1 (PARP1)	OT310QSG	PARP1_HUMAN	Gene/Protein Processing	[8]
Renin (REN)	OT52GZR2	RENI_HUMAN	Gene/Protein Processing	[9]
Vasodilator-stimulated phosphoprotein	OTFC3010	VASP_HUMAN	Post-Translational Modifications	[10]

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