Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMH1M9B)

Drug Name
Benazepril Drug Info
Synonyms
Benazapril; Benazeprilum; Benzazepril; Benazepril Sandoz; Benazeprilum [Latin]; Forteekor [veterinary]; Benazepril (INN); Benazepril Sandoz (TN); Benazepril [INN:BAN]; Forteekor [veterinary] (TN); Fortekor (TN); Lotensin (TN); CGS-14824-A; [(3S)-3-{[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino}-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]acetic acid; [(3S)-3-({(1S)-1-[(ethyloxy)carbonyl]-3-phenylpropyl}amino)-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]acetic acid; [(3S)-3-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]acetic acid; 2-[(3S)-3-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]-2-oxo-4,5-dihydro-3H-1-benzazepin-1-yl]acetic acid
Indication
Disease Entry ICD 11 Status REF
Hypertension BA00-BA04 Approved [1]
Malignant essential hypertension BA00 Approved [2]
Therapeutic Class
Antihypertensive Agents
Cross-matching ID
PubChem CID
5362124
ChEBI ID
CHEBI:3011
CAS Number
CAS 86541-75-5
TTD Drug ID
DMH1M9B
VARIDT Drug ID
DR00286
INTEDE Drug ID
DR0186
ACDINA Drug ID
D00060

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Angiotensin-converting enzyme (ACE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Enalapril DMNFUZR Congestive heart failure BD10 Approved [15]
Spirapril DM5XLTY Hypertension BA00-BA04 Approved [16]
Captopril DM458UM Chronic heart failure BD1Z Approved [17]
Moexipril DM26E4B Hypertension BA00-BA04 Approved [18]
Ramipril DM2R68E Acute heart failure BD10-BD13 Approved [19]
Perindopril DMOPZDT Hypertension BA00-BA04 Approved [20]
Trandolapril DM4L6EU Chronic heart failure BD1Z Approved [21]
Fosinopril DM9NJ52 Chronic heart failure BD1Z Approved [22]
Lisinopril DMUOK4C Chronic heart failure BD1Z Approved [23]
Enalaprilat DMFYAM1 Congestive heart failure BD10 Approved [24]
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Drug(s) Transported By Peptide transporter 1 (SLC15A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [25]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [26]
Ampicillin DMHWE7P Acute epiglottitis Approved [27]
Losartan DM72JXH Diabetic kidney disease GB61.Z Approved [28]
Enalapril DMNFUZR Congestive heart failure BD10 Approved [29]
Cefazolin DMPDYFR Bacteremia 1A73 Approved [30]
Ceftriaxone DMCEW64 Acute gonococcal cervicitis Approved [31]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [26]
Cefadroxil DMMC345 Bacterial infection 1A00-1C4Z Approved [28]
Irbesartan DMTP1DC Diabetic kidney disease GB61.Z Approved [28]
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Drug(s) Transported By Peptide transporter 2 (SLC15A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [25]
Ampicillin DMHWE7P Acute epiglottitis Approved [32]
Enalapril DMNFUZR Congestive heart failure BD10 Approved [33]
Entecavir DM7VTQO Hepatitis B virus infection 1E51.0 Approved [34]
Cefadroxil DMMC345 Bacterial infection 1A00-1C4Z Approved [35]
Cephalexin DMD5JU8 Acute otitis media AB00 Approved [32]
Valaciclovir DMHKS94 Genital herpes 1A94 Approved [36]
Cefaclor DMJXDGC Bacterial infection 1A00-1C4Z Approved [25]
Aminolevulinic acid hci DMS4BLQ Acne vulgaris ED80 Approved [37]
Spirapril DM5XLTY Hypertension BA00-BA04 Approved [4]
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Drug(s) Metabolized By Methylenetetrahydrofolate reductase (MTHFR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [38]
Folic Acid DMEMBJC Colorectal carcinoma Approved [39]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [40]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [41]
ISO-901 DMBQ8CA N. A. N. A. Phase 1 [42]
Folic Acid DMEMBJC Colorectal carcinoma Approved [43]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [44]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [45]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [46]
Testosterone DM7HUNW Hot flushes GA30 Approved [47]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [47]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [48]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [49]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [50]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [51]
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Drug(s) Affected By Toll-like receptor 4 (TLR4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [52]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [53]
Quercetin DM3NC4M Obesity 5B81 Approved [54]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [55]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [56]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [57]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [58]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [48]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [59]
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Drug(s) Affected By Renin (REN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [60]
Acebutolol DM0TI4U Hypertension BA00-BA04 Approved [61]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [62]
Reboxetine DM26PRD Depression 6A70-6A7Z Approved [63]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [64]
Ramipril DM2R68E Acute heart failure BD10-BD13 Approved [65]
Rhucin DM3ADGP Erectile dysfunction HA01.1 Approved [66]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [67]
Epinephrine DM3KJBC Acute asthma CA23 Approved [68]
Chlorthalidone DM4DMBT Edema MG29 Approved [69]
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Drug(s) Affected By Angiotensinogen (AGT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [70]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [71]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [72]
Reboxetine DM26PRD Depression 6A70-6A7Z Approved [63]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [73]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [74]
Rhucin DM3ADGP Erectile dysfunction HA01.1 Approved [66]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Lisinopril DMUOK4C Chronic heart failure BD1Z Approved [76]
Irbesartan DMTP1DC Diabetic kidney disease GB61.Z Approved [77]
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Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Gabapentin DM6T924 Complex partial seizure 8A68.0 Approved [79]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [80]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [81]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [82]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [83]
Prednisone DM2HG4X Acute asthma CA23 Approved [84]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [85]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [86]
Methotrexate DM2TEOL Anterior urethra cancer Approved [52]
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Drug(s) Affected By Tumor necrosis factor (TNF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [87]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [88]
Fructose DM43AN2 Vomiting MD90 Approved [79]
Ketoprofen DMRKXPT Bursitis Approved [79]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [89]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [90]
Baclofen DM0QV1J Multiple sclerosis 8A40 Approved [91]
Gefitinib DM15F0X Colon adenocarcinoma Approved [92]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [93]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [94]
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Drug(s) Affected By Protein AMBP (AMBP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [95]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [96]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [97]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [59]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [98]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [48]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [99]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [100]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [101]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [102]
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Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [103]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [104]
Gefitinib DM15F0X Colon adenocarcinoma Approved [92]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [94]
Selenium DM25CGV N. A. N. A. Approved [105]
Pentosan Polysulfate DM2HRKE Interstitial cystitis GC00.3 Approved [106]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [107]
Methotrexate DM2TEOL Anterior urethra cancer Approved [108]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [109]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [110]
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Drug(s) Affected By Methionine synthase (MTR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Folic Acid DMEMBJC Colorectal carcinoma Approved [111]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [112]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [113]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [114]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [115]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [116]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [99]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [117]
Nitrous oxide DMTHWBI Anxiety disorder 6B00-6B0Z Approved [118]
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Drug(s) Affected By Cytochrome P450 11B2, mitochondrial (CYP11B2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aldosterone DM9S2JW Hypertension BA00-BA04 Approved [119]
FADROZOLE DM3C5GZ Breast cancer 2C60-2C65 Approved [120]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [121]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [48]
Potassium Chloride DMMTAJC Hypokalemia 5C77 Approved [122]
Dutasteride DMQ4TJK Benign prostatic hyperplasia GA90 Approved [123]
Mitotane DMU1GX0 Adrenocortical carcinoma 2D11.Z Approved [124]
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [121]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [125]
Irbesartan DMTP1DC Diabetic kidney disease GB61.Z Approved [126]
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Drug(s) Affected By Lysosomal Pro-X carboxypeptidase (PRCP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [46]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [98]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [48]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [116]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [127]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [99]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [100]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [128]
Gentamicin DMKINJO Bacteremia 1A73 Approved [79]
Urethane DM7NSI0 N. A. N. A. Phase 4 [129]
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Drug(s) Affected By Beta-2 adrenergic receptor (ADRB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Salmeterol DMIEU69 Allergic asthma CA23.0 Approved [130]
Bambuterol DMKLSHF Asthma CA23 Approved [131]
Terbutaline DMD4381 Asthma CA23 Approved [132]
Salbutamol DMN9CWF Acute asthma CA23 Approved [133]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [134]
Methotrexate DM2TEOL Anterior urethra cancer Approved [135]
Epinephrine DM3KJBC Acute asthma CA23 Approved [136]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [46]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [137]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [138]
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Drug(s) Affected By Angiotensin-converting enzyme 2 (ACE2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Captopril DM458UM Chronic heart failure BD1Z Approved [139]
Diazepam DM08E9O Alcohol withdrawal Approved [140]
Dantrolene DM1D8XY Hyperthermia MG26 Approved [140]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [140]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [140]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [140]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [140]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [140]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [140]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [140]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Angiotensin-converting enzyme (ACE) TTL69WB ACE_HUMAN Inhibitor [3]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Peptide transporter 2 (SLC15A2) DT8QKNP S15A2_HUMAN Substrate [4]
Peptide transporter 1 (SLC15A1) DT9G7XN S15A1_HUMAN Substrate [4]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Methylenetetrahydrofolate reductase (MTHFR) Main DME DEOXTPZ MTHR_HUMAN Substrate [5]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Angiotensin-converting enzyme 2 (ACE2) OTTRZGU7 ACE2_HUMAN Drug Response [6]
Angiotensinogen (AGT) OTBZLYR3 ANGT_HUMAN Gene/Protein Processing [7]
Beta-2 adrenergic receptor (ADRB2) OTSDOX4Q ADRB2_HUMAN Drug Response [8]
Cytochrome P450 11B2, mitochondrial (CYP11B2) OTIOLWYN C11B2_HUMAN Drug Response [9]
Lysosomal Pro-X carboxypeptidase (PRCP) OTIUY91L PCP_HUMAN Drug Response [10]
Matrix metalloproteinase-9 (MMP9) OTB2QDAV MMP9_HUMAN Gene/Protein Processing [11]
Methionine synthase (MTR) OTF2K2TA METH_HUMAN Drug Response [5]
Methylenetetrahydrofolate reductase (MTHFR) OTUBJSR7 MTHR_HUMAN Drug Response [12]
Protein AMBP (AMBP) OTLU8GU8 AMBP_HUMAN Gene/Protein Processing [13]
Renin (REN) OT52GZR2 RENI_HUMAN Gene/Protein Processing [14]

References

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2 Amlodipine FDA Label
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27 Several hPepT1-transported drugs are substrates of the Escherichia coli proton-coupled oligopeptide transporter YdgR. Res Microbiol. 2017 Jun;168(5):443-449.
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35 Species Differences in Human and Rodent PEPT2-Mediated Transport of Glycylsarcosine and Cefadroxil in Pichia Pastoris Transformants. Drug Metab Dispos. 2017 Feb;45(2):130-136.
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38 The pharmacogenetics of methotrexate. Rheumatology (Oxford). 2007 Oct;46(10):1520-4.
39 Genetic variation: impact on folate (and choline) bioefficacy. Int J Vitam Nutr Res. 2010 Oct;80(4-5):319-29.
40 5-Fluorouracil pharmacogenomics: still rocking after all these years? Pharmacogenomics. 2011 Feb;12(2):251-65.
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44 Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphism in normal tissue as predictors of fluorouracil sensitivity. J Clin Oncol. 2005 Mar 1;23(7):1365-9. doi: 10.1200/JCO.2005.06.219.
45 Homocysteine modulates the effect of simvastatin on expression of ApoA-I and NF-kappaB/iNOS. Cardiovasc Res. 2008 Oct 1;80(1):151-8.
46 Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
47 Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
48 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
49 Gene expression analysis of precision-cut human liver slices indicates stable expression of ADME-Tox related genes. Toxicol Appl Pharmacol. 2011 May 15;253(1):57-69.
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