Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMP36KD)

• Drug Name: MLN4924 Drug Info
• Synonyms: Pevonedistat; 905579-51-3; MLN4924; MLN-4924; MLN 4924; UNII-S3AZD8D215; S3AZD8D215; Sulfamic acid [(1S,2S,4R)-4-[4-[[(1S)-2,3-dihydro-1H-inden-1-yl]amino]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-2-hydroxycyclopentyl]methyl ester; ((1S,2S,4R)-4-(4-(((S)-2,3-dihydro-1H-inden-1-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-hydroxycyclopentyl)methyl sulfamate; C21H25N5O4S; [(1s,2s,4r)-4-{4-[(1s)-2,3-Dihydro-1h-Inden-1-Ylamino]-7h-Pyrrolo[2,3-D]pyrimidin-7-Yl}-2-Hydroxycyclopentyl]methyl Sulfamate; Pevonedistat [USAN:INN]; 3gzn

Indication

Disease Entry	ICD 11	Status	REF
Myelodysplastic syndrome	2A37	Phase 3	[1]
Acute myelogenous leukaemia	2A41	Phase 2	[2]
Advanced malignancy	2A00-2F9Z	Phase 1	[3]
Nasopharyngeal carcinoma	2B6B	Investigative	[4]

• Cross-matching ID:
  PubChem CID: 16720766
  ChEBI ID: CHEBI:95028
  CAS Number: CAS 905579-51-3
  TTD Drug ID: DMP36KD

Molecule-Related Drug Atlas

Drug(s) Affected By C-C motif chemokine 22 (CCL22)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[7]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[8]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[9]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[10]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[11]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[12]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[13]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[14]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[15]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[16]

Drug(s) Affected By CASP8 and FADD-like apoptosis regulator (CFLAR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[17]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[18]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[19]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[20]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[21]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[22]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[23]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[25]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[26]

Drug(s) Affected By Bcl-2-like protein 11 (BCL2L11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[27]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[28]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[31]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[32]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[33]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[34]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[35]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[36]

Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 beta (GADD45B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[37]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[38]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[39]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[40]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[33]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[42]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[43]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[44]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[45]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[38]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[46]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[47]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[48]
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[50]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[28]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[51]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]

Drug(s) Affected By HLA class II histocompatibility antigen gamma chain (CD74)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[53]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[33]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[55]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[56]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[37]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[61]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[63]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[64]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[65]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[64]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[66]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[67]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[68]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[69]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[70]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[71]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[72]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[73]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[37]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[74]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[75]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[76]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[77]

Drug(s) Affected By C-C motif chemokine 5 (CCL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[78]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[80]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[81]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[84]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[85]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[86]

Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[87]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[88]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[38]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[89]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[90]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[91]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[92]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[93]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[94]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[22]

Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[95]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[96]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[77]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[97]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[98]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[99]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[100]
Selenium	DM25CGV	N. A.	N. A.	Approved	[53]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[50]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[101]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 5 (CD40)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[102]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[103]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[104]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[105]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[106]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[103]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[107]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[108]

Drug(s) Affected By NF-kappa-B inhibitor alpha (NFKBIA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fructose	DM43AN2	Vomiting	MD90	Approved	[73]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[109]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[102]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[110]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[111]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[112]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[113]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[114]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[115]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[116]

Drug(s) Affected By G1/S-specific cyclin-D2 (CCND2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[117]
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[40]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[118]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[119]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[120]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[121]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[122]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[123]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]

Drug(s) Affected By C-X-C chemokine receptor type 5 (CXCR5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[124]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[83]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[125]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[126]

Drug(s) Affected By Signal transducer and activator of transcription 5A (STAT5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[127]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[128]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[44]
Quizartinib	DM8Y4JS	Acute myeloid leukaemia	2A60	Approved	[129]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[130]

Drug(s) Affected By C-X-C chemokine receptor type 3 (CXCR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[73]
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[132]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[133]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[134]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[135]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[15]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[107]
Nickel chloride	DMI12Y8	Discovery agent	N.A.	Investigative	[134]

Drug(s) Affected By Heat shock factor protein 1 (HSF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[136]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[137]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[137]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[138]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[139]
Ceftazidime	DM41GRA	Bacteremia	1A73	Approved	[137]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Chlorpheniramine	DM5URA2	Allergic rhinitis	CA08.0	Approved	[137]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[137]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[137]

Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[102]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[77]
Selenium	DM25CGV	N. A.	N. A.	Approved	[53]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[140]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[94]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[115]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[116]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[141]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[142]

Drug(s) Affected By C-X-C motif chemokine 9 (CXCL9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[17]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[144]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[145]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[123]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[107]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[145]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[147]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[148]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[149]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[63]
Selenium	DM25CGV	N. A.	N. A.	Approved	[53]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[150]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[40]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[151]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[21]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[22]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[152]

Drug(s) Affected By Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[153]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[39]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[63]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[154]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[155]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[116]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[156]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[157]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[158]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[159]

Drug(s) Affected By Rapamycin-insensitive companion of mTOR (RICTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[39]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[161]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[162]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[39]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[163]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[164]

Drug(s) Affected By Regulatory-associated protein of mTOR (RPTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[165]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[167]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[168]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[170]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[171]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[172]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[164]

Drug(s) Affected By C-C motif chemokine 17 (CCL17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[7]
Budesonide	DMJIBAW	Allergic rhinitis	CA08.0	Approved	[173]
Isoproterenol	DMK7MEY	Atrioventricular block		Approved	[174]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[11]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[14]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[15]

Drug(s) Affected By Bcl-2-binding component 3, isoforms 3/4 (BBC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[171]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[63]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[175]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[154]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[176]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[177]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[157]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[178]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[179]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[35]

Drug(s) Affected By Repressor of RNA polymerase III transcription MAF1 homolog (MAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[180]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[181]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[182]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[15]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[183]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[160]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[160]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[184]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
NEDD8-activating enzyme (NAE)	TTVKOPM	ULA1_HUMAN; UBA3_HUMAN	Modulator	[5]
Ubiquitin-like protein Nedd8 (NEDD8)	TTNDC4K	NEDD8_HUMAN	Inhibitor	[4]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[6]
Bcl-2-binding component 3, isoforms 3/4 (BBC3)	OTUAXDAY	BBC3B_HUMAN	Gene/Protein Processing	[6]
Bcl-2-like protein 1 (BCL2L1)	OTRC5K9O	B2CL1_HUMAN	Gene/Protein Processing	[6]
Bcl-2-like protein 11 (BCL2L11)	OTNQQWFJ	B2L11_HUMAN	Gene/Protein Processing	[6]
C-C motif chemokine 17 (CCL17)	OTIKW21L	CCL17_HUMAN	Gene/Protein Processing	[6]
C-C motif chemokine 22 (CCL22)	OTT3QJC2	CCL22_HUMAN	Gene/Protein Processing	[6]
C-C motif chemokine 5 (CCL5)	OTSCA5CK	CCL5_HUMAN	Gene/Protein Processing	[6]
C-X-C chemokine receptor type 3 (CXCR3)	OTIGS220	CXCR3_HUMAN	Gene/Protein Processing	[6]
C-X-C chemokine receptor type 5 (CXCR5)	OTVBCQZX	CXCR5_HUMAN	Gene/Protein Processing	[6]
C-X-C motif chemokine 9 (CXCL9)	OTMFVZKZ	CXCL9_HUMAN	Gene/Protein Processing	[6]

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