General Information of Drug (ID: DMX9V8K)

Drug Name
CONTIGOSIDE B Drug Info
Synonyms
Isoquercitrin; Isoquercetin; 482-35-9; Hirsutrin; 3-Glucosylquercetin; Glucosyl 3-quercetin; Quercetin 3-glucoside; Quercetol 3-glucoside; Quercetin 3-o-glucopyranoside; Quercetin 3-D-glucoside; Quercetol 3-monoglucoside; Quercetin 3-monoglucoside; Isotrifoliin; Quercetin 3-beta-glucoside; Quercetin 3-O-glucoside; quercetin-3-glucoside; Quercetin 3-beta-O-glucoside; Quercetin-3-O-glucopyranoside; UNII-6HN2PC637T; quercetin-3-O-glucoside; NSC 115918; BRN 0100989; CHEMBL250450; 6HN2PC637T; CHEBI:68352; quercetin 3-O-beta-D-glucopyran
Indication
Disease Entry ICD 11 Status REF
Thrombosis DB61-GB90 Phase 2/3 [1]
Cross-matching ID
PubChem CID
5280804
ChEBI ID
CHEBI:68352
CAS Number
CAS 482-35-9
TTD Drug ID
DMX9V8K
INTEDE Drug ID
DR2159

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Drug(s) Targeting Aldose reductase (AKR1B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Epalrestat DM5OGK0 Diabetic neuropathy 8C0Z Approved [9]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [10]
Fidarestat DMZL1I8 Diabetic complication 5A2Y Phase 3 [11]
Ranirestat DMD5QRS Diabetic neuropathy 8C0Z Phase 3 [12]
BNV-222 DMYFQJL Diabetic neuropathy 8C0Z Phase 2/3 [12]
BNV-222 DMYFQJL Diabetic neuropathy 8C0Z Phase 2/3 [13]
LIDORESTAT DMA0RI9 Diabetic complication 5A2Y Phase 2 [14]
QR-333 DMKVIWM Diabetic neuropathy 8C0Z Phase 2 [15]
ADMVA DM819CO Diabetic complication 5A2Y Phase 2 [12]
M-16209 DMZ7YX3 Diabetic complication 5A2Y Phase 2 [16]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Enalapril DMNFUZR Congestive heart failure BD10 Approved [17]
Spirapril DM5XLTY Hypertension BA00-BA04 Approved [18]
Captopril DM458UM Chronic heart failure BD1Z Approved [19]
Benazepril DMH1M9B Hypertension BA00-BA04 Approved [20]
Moexipril DM26E4B Hypertension BA00-BA04 Approved [21]
Ramipril DM2R68E Acute heart failure BD10-BD13 Approved [22]
Perindopril DMOPZDT Hypertension BA00-BA04 Approved [23]
Trandolapril DM4L6EU Chronic heart failure BD1Z Approved [24]
Fosinopril DM9NJ52 Chronic heart failure BD1Z Approved [25]
Lisinopril DMUOK4C Chronic heart failure BD1Z Approved [26]
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Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [27]
Riluzole DMECBWN Amyotrophic lateral sclerosis 8B60.0 Approved [28]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [29]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [30]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [31]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [32]
Ethacrynic acid DM60QMR Edema MG29 Approved [33]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [34]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [35]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [36]
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Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [28]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [37]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [38]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [39]
Estrone DM5T6US Acne vulgaris ED80 Approved [40]
Melatonin DMKWFBT Depression 6A70-6A7Z Approved [41]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [42]
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [43]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [44]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [45]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Momelotinib DMF98Q0 Myelofibrosis 2A20.2 Approved [46]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [47]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [48]
Quercetin DM3NC4M Obesity 5B81 Approved [49]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [50]
Paroxetine DM5PVQE Anxiety disorder 6B00-6B0Z Approved [51]
Estrone DM5T6US Acne vulgaris ED80 Approved [47]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Amlodipine DMBDAZV Angina pectoris BA40 Approved [54]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Pentoxifylline DMU3DNC Alcoholic hepatitis DB94.1 Approved [55]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [56]
Verapamil DMA7PEW Angina pectoris BA40 Approved [57]
Selenium DM25CGV N. A. N. A. Approved [58]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [57]
Quercetin DM3NC4M Obesity 5B81 Approved [59]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [60]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [61]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [62]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [63]
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Drug(s) Affected By Apolipoprotein A-I (APOA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [64]
Quercetin DM3NC4M Obesity 5B81 Approved [65]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [60]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [66]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [67]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [68]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [69]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [70]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [71]
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Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [72]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [73]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [74]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [45]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [75]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [76]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [77]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [78]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [79]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [77]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [80]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [81]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [82]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [83]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [55]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [84]
Verapamil DMA7PEW Angina pectoris BA40 Approved [85]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [86]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [87]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [88]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [89]
Quercetin DM3NC4M Obesity 5B81 Approved [49]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [61]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [90]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [91]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [92]
Tofacitinib DMBS370 Rheumatoid arthritis FA20 Approved [93]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [94]
Clozapine DMFC71L Schizophrenia 6A20 Approved [95]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [96]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [97]
Quercetin DM3NC4M Obesity 5B81 Approved [98]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [60]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [99]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [100]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [101]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [102]
Testosterone DM7HUNW Hot flushes GA30 Approved [103]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [104]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Catenin beta-1 (CTNNB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [105]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [106]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [107]
Quercetin DM3NC4M Obesity 5B81 Approved [108]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [109]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [110]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [111]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [112]
Testosterone DM7HUNW Hot flushes GA30 Approved [113]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [114]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [55]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [115]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [116]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [117]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [118]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [119]
Methotrexate DM2TEOL Anterior urethra cancer Approved [120]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [121]
Cladribine DM3JDRP Hairy cell leukaemia 2A82.2 Approved [122]
Quercetin DM3NC4M Obesity 5B81 Approved [123]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [115]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [124]
Methotrexate DM2TEOL Anterior urethra cancer Approved [120]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [125]
Panobinostat DM58WKG Chronic graft versus host disease Approved [126]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [127]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [124]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [94]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [128]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [129]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [115]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [130]
Quercetin DM3NC4M Obesity 5B81 Approved [49]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [50]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [131]
Adenosine triphosphate DM79F6G Malnutrition 5B50-5B71 Approved [132]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [133]
Cantharidin DMBP5N3 Molluscum contagiosum infection 1E76 Approved [134]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [135]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [94]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [136]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [137]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [138]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [139]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [140]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [141]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [142]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [143]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [144]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [145]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [146]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [147]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [130]
Methotrexate DM2TEOL Anterior urethra cancer Approved [148]
Quercetin DM3NC4M Obesity 5B81 Approved [149]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [150]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [131]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [151]
Testosterone DM7HUNW Hot flushes GA30 Approved [152]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [152]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [87]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [153]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [154]
Methotrexate DM2TEOL Anterior urethra cancer Approved [155]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [156]
Quercetin DM3NC4M Obesity 5B81 Approved [108]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [157]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [153]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [158]
Ethacrynic acid DM60QMR Edema MG29 Approved [159]
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Drug(s) Affected By Caspase-8 (CASP8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [160]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [161]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [162]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [115]
Gefitinib DM15F0X Colon adenocarcinoma Approved [163]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [164]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [165]
Selenium DM25CGV N. A. N. A. Approved [166]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [167]
Methotrexate DM2TEOL Anterior urethra cancer Approved [148]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Aldose reductase (AKR1B1) TTFBNVI ALDR_HUMAN Inhibitor [2]
Angiotensin-converting enzyme (ACE) TTL69WB ACE_HUMAN Inhibitor [3]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Beta-glucosidase (bglA) DEXLYGD Q9ZNN7_BACSP Substrate [4]
Beta-glucosidase (bglA) DEZXOEW R5RU84_9BACE Substrate [4]
Beta-glucosidase (bglA) DE4WCJL R5RU84_9BACE Substrate [4]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apolipoprotein A-I (APOA1) OT5THARI APOA1_HUMAN Protein Interaction/Cellular Processes [5]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [6]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [6]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Gene/Protein Processing [6]
Catenin beta-1 (CTNNB1) OTZ932A3 CTNB1_HUMAN Gene/Protein Processing [6]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Gene/Protein Processing [7]
Cytochrome P450 1B1 (CYP1B1) OTYXFLSD CP1B1_HUMAN Gene/Protein Processing [7]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) OT2YYI1A MCL1_HUMAN Gene/Protein Processing [6]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Gene/Protein Processing [6]
Metalloproteinase inhibitor 1 (TIMP1) OTOXC51H TIMP1_HUMAN Gene/Protein Processing [8]

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 Effect of Polygonum hydropiper sulfated flavonoids on lens aldose reductase and related enzymes. J Nat Prod. 1996 Apr;59(4):443-5.
3 Inhibitory effects of various flavonoids isolated from leaves of persimmon on angiotensin-converting enzyme activity. J Nat Prod. 1987 Jul-Aug;50(4):680-3.
4 Identification of rutin deglycosylated metabolites produced by human intestinal bacteria using UPLC-Q-TOF/MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Jun 1;898:95-100.
5 Induction of hepatic apolipoprotein A-I gene expression by the isoflavones quercetin and isoquercetrin. Life Sci. 2014 Aug 6;110(1):8-14. doi: 10.1016/j.lfs.2014.06.014. Epub 2014 Jun 22.
6 Improved Preventive Effects of Combined Bioactive Compounds Present in Different Blueberry Varieties as Compared to Single Phytochemicals. Nutrients. 2018 Dec 29;11(1):61. doi: 10.3390/nu11010061.
7 Inhibition of human cytochrome CYP 1 enzymes by flavonoids of StJohn's wort. Toxicology. 2006 Jan 16;217(2-3):194-205.
8 Flavonoid glycosides isolated from Salicornia herbacea inhibit matrix metalloproteinase in HT1080 cells. Toxicol In Vitro. 2008 Oct;22(7):1742-8. doi: 10.1016/j.tiv.2008.07.013. Epub 2008 Jul 31.
9 Long-term effect of epalrestat, an aldose reductase inhibitor, on the development of incipient diabetic nephropathy in Type 2 diabetic patients. J Diabetes Complications. 2001 Sep-Oct;15(5):241-4.
10 Inhibition of human lens aldose reductase by flavonoids, sulindac and indomethacin. Biochem Pharmacol. 1983 Jul 1;32(13):1995-8.
11 Clinical efficacy of fidarestat, a novel aldose reductase inhibitor, for diabetic peripheral neuropathy: a 52-week multicenter placebo-controlled double-blind parallel group study. Diabetes Care. 2001 Oct;24(10):1776-82.
12 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2768).
13 ClinicalTrials.gov (NCT02332005) 12-Month Efficacy and Safety of Diepalrestat in Adults With Diabetic Peripheral Neuropathy, a DB, Placebo-Controlled Study (DE-DPN). U.S. National Institutes of Health.
14 Discovery of 3-[(4,5,7-trifluorobenzothiazol-2-yl)methyl]indole-N-acetic acid (lidorestat) and congeners as highly potent and selective inhibitors ... J Med Chem. 2005 May 5;48(9):3141-52.
15 A multicenter, double-blind, safety study of QR-333 for the treatment of symptomatic diabetic peripheral neuropathy. A preliminary report. J Diabetes Complications. 2005 Sep-Oct;19(5):247-53.
16 Effects of novel aldose reductase inhibitors, M16209 and M16287, on streptozotocin-induced diabetic neuropathy in rats. Eur J Pharmacol. 1991 Feb 7;193(2):185-91.
17 Determination of bezafibrate, methotrexate, cyclophosphamide, orlistat and enalapril in waste and surface waters using on-line solid-phase extracti... J Environ Monit. 2009 Apr;11(4):830-8.
18 Central angiotensin II controls alcohol consumption via its AT1 receptor. FASEB J. 2005 Sep;19(11):1474-81.
19 Using ACE inhibitors appropriately. Am Fam Physician. 2002 Aug 1;66(3):461-8.
20 Efficacy of benazepril hydrochloride to delay the progression of occult dilated cardiomyopathy in Doberman Pinschers. J Vet Intern Med. 2009 Sep-Oct;23(5):977-83.
21 Moexipril for treatment of primary biliary cirrhosis in patients with an incomplete response to ursodeoxycholic acid. Dig Dis Sci. 2010 Feb;55(2):476-83.
22 Knockouts model the 100 best-selling drugs--will they model the next 100 Nat Rev Drug Discov. 2003 Jan;2(1):38-51.
23 Fixed combination perindopril-amlodipine (Coveram) in the treatment of hypertension and coronary heart disease. Rev Med Liege. 2009 Apr;64(4):223-7.
24 Selective reduction of central pulse pressure under angiotensin blockage in SHR: role of the fibronectin-alpha5beta1 integrin complex. Am J Hypertens. 2009 Jul;22(7):711-7.
25 Angiotensin-converting enzyme inhibition and novel cardiovascular risk biomarkers: results from the Trial of Angiotensin Converting Enzyme Inhibition and Novel Cardiovascular Risk Factors (TRAIN) study. Am Heart J. 2009 Feb;157(2):334.e1-8.
26 Involvement of vascular angiotensin II-forming enzymes in the progression of aortic abdominal aneurysms in angiotensin II- infused ApoE-deficient m... J Atheroscler Thromb. 2009 Jun;16(3):164-71.
27 Cytochrome P450 1A1/2 induction by antiparasitic drugs: dose-dependent increase in ethoxyresorufin O-deethylase activity and mRNA caused by quinine, primaquine and albendazole in HepG2 cells. Eur J Clin Pharmacol. 2002 Nov;58(8):537-42.
28 Association of CYP1A1 and CYP1B1 inhibition in in vitro assays with drug-induced liver injury. J Toxicol Sci. 2021;46(4):167-176. doi: 10.2131/jts.46.167.
29 Anti-androgenic effect of 6-formylindolo[3,2-b]carbazole (FICZ) in LNCaP cells is mediated by the aryl hydrocarbon-androgen receptors cross-talk. Steroids. 2020 Jan;153:108508. doi: 10.1016/j.steroids.2019.108508. Epub 2019 Oct 3.
30 Pharmacologic profiling of human and rat cytochrome P450 1A1 and 1A2 induction and competition. Arch Toxicol. 2008 Dec;82(12):909-21.
31 Effect of CYP1A1 gene polymorphisms on estrogen metabolism and bone density. J Bone Miner Res. 2005 Feb;20(2):232-9. doi: 10.1359/JBMR.041110. Epub 2004 Nov 16.
32 Increased sensitivity for troglitazone-induced cytotoxicity using a human in vitro co-culture model. Toxicol In Vitro. 2009 Oct;23(7):1387-95.
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34 Gene expression changes in human small airway epithelial cells exposed to Delta9-tetrahydrocannabinol. Toxicol Lett. 2005 Aug 14;158(2):95-107.
35 The metallohormone cadmium modulates AhR-associated gene expression in the small intestine of rats similar to ethinyl-estradiol. Arch Toxicol. 2013 Apr;87(4):633-43.
36 Evidence for a new human CYP1A1 regulation pathway involving PPAR-alpha and 2 PPRE sites. Gastroenterology. 2004 Nov;127(5):1436-45.
37 Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells. Cancer Res. 2002 Nov 1;62(21):6246-54.
38 Convergent transcriptional profiles induced by endogenous estrogen and distinct xenoestrogens in breast cancer cells. Carcinogenesis. 2006 Aug;27(8):1567-78.
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