Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM1DH96)

• Drug Name: QUERCITRIN Drug Info
• Synonyms: quercitrin; 522-12-3; Quercetrin; Quercetin 3-rhamnoside; Quercitroside; Quercimelin; Thujin; Quercetin 3-L-rhamnoside; Quercitronic acid; Quercetin 3-O-rhamnoside; UNII-2Y8906LC5P; CHEBI:17558; Quercetin 3-O-alpha-L-rhamnoside; Quercetin-3-L-rhamnoside; 3,3',4',5,7-Pentahydroxyflavone-3-L-rhamnoside; Quercetin-3-rhamnoside; NSC9221; Quercetin, 3-(6-deoxy-alpha-L-mannopyranoside); 2Y8906LC5P; Mannopyranoside, quercetin-3 6-deoxy-, alpha-L-; Quercetin 3-O-alpha-rhamnopyranoside; Usaf cf-2; Quercetrin-3-O-rham

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 5280459
  ChEBI ID: CHEBI:17558
  CAS Number: CAS 522-12-3
  TTD Drug ID: DM1DH96

Molecule-Related Drug Atlas

Drug(s) Targeting Aldose reductase (AKR1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Epalrestat	DM5OGK0	Diabetic neuropathy	8C0Z	Approved	[3]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[4]
Fidarestat	DMZL1I8	Diabetic complication	5A2Y	Phase 3	[5]
Ranirestat	DMD5QRS	Diabetic neuropathy	8C0Z	Phase 3	[6]
CONTIGOSIDE B	DMX9V8K	Thrombosis	DB61-GB90	Phase 2/3	[7]
BNV-222	DMYFQJL	Diabetic neuropathy	8C0Z	Phase 2/3	[6]
BNV-222	DMYFQJL	Diabetic neuropathy	8C0Z	Phase 2/3	[8]
LIDORESTAT	DMA0RI9	Diabetic complication	5A2Y	Phase 2	[9]
QR-333	DMKVIWM	Diabetic neuropathy	8C0Z	Phase 2	[10]
ADMVA	DM819CO	Diabetic complication	5A2Y	Phase 2	[6]

Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[11]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[12]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[13]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[14]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[15]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[16]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[17]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[18]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[19]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[20]

Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[12]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[21]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[22]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[23]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[24]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[25]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[26]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[27]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[28]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[29]

Drug(s) Affected By ERI1 exoribonuclease 2 (ERI2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[31]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[32]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[34]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[35]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[36]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[37]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[38]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[39]

Drug(s) Affected By Proteinase-activated receptor 3 (F2RL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[41]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[34]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[45]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[41]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[47]

Drug(s) Affected By DNA-directed RNA polymerase, mitochondrial (POLRMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[36]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[48]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[49]
Zalcitabine	DMH7MUV	Human immunodeficiency virus infection	1C62	Approved	[49]
Didanosine	DMI2QPE	Human immunodeficiency virus infection	1C62	Approved	[49]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[48]
INX-189	DMSTJ6Q	Hepatitis C virus infection	1E51.1	Phase 2	[50]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[51]

Drug(s) Affected By C-C chemokine receptor-like 2 (CCRL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[52]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[53]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[55]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[56]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[57]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[47]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[58]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[51]

Drug(s) Affected By Histone deacetylase complex subunit SAP18 (SAP18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[59]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[60]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[61]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[62]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[63]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[37]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[38]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[51]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[39]

Drug(s) Affected By Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (PIK3C2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[64]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[67]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[68]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[69]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[70]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[36]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[71]

Drug(s) Affected By Golgi integral membrane protein 4 (GOLIM4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[72]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[61]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[72]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[72]

Drug(s) Affected By Claudin-4 (CLDN4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[75]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[76]
Selenium	DM25CGV	N. A.	N. A.	Approved	[77]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[78]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[79]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[80]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[41]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[81]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[76]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[42]

Drug(s) Affected By Adhesion G protein-coupled receptor B1 (ADGRB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[77]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[35]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[47]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[77]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[51]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[83]

Drug(s) Affected By Chromodomain-helicase-DNA-binding protein 2 (CHD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[60]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[84]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[85]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[86]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[61]
Bortezomib	DMNO38U	Leukemia		Approved	[68]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[87]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[88]

Drug(s) Affected By Monocarboxylate transporter 5 (SLC16A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[60]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[90]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[91]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[92]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[55]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[93]

Drug(s) Affected By ATP-binding cassette sub-family C member 4 (ABCC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[94]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[95]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[96]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[97]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[98]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[99]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[100]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[101]

Drug(s) Affected By Zinc finger protein SNAI2 (SNAI2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[102]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[103]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[104]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[105]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[105]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[86]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[106]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]

Drug(s) Affected By Alpha-actinin-4 (ACTN4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[77]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[107]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[61]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[108]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[55]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[109]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[77]

Drug(s) Affected By Integral membrane protein GPR137B (GPR137B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[77]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[110]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[105]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[105]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[67]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[55]

Drug(s) Affected By Protein O-GlcNAcase (OGA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[111]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[112]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[113]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[86]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[67]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[36]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[71]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[37]

Drug(s) Affected By Galanin receptor type 3 (GALR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[114]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[77]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[51]

Drug(s) Affected By Splicing factor 3B subunit 1 (SF3B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[111]
Selenium	DM25CGV	N. A.	N. A.	Approved	[77]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[60]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[115]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[116]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[63]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[77]

Drug(s) Affected By Gamma-aminobutyric acid type B receptor subunit 2 (GABBR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[118]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[35]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[119]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[120]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[31]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[41]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[51]

Drug(s) Affected By Ubiquitin-like modifier-activating enzyme ATG7 (ATG7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[121]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[122]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[98]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[124]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[125]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[127]

Drug(s) Affected By Quinone oxidoreductase-like protein 1 (CRYZL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[61]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[88]
methyl p-hydroxybenzoate	DMO58UW	Discovery agent	N.A.	Investigative	[128]

Drug(s) Affected By Interferon alpha-1/13 (IFNA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[129]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[130]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[131]
PMID28870136-Compound-48	DMPIM9L	N. A.	N. A.	Patented	[132]

Drug(s) Affected By HLA class II histocompatibility antigen, DQ alpha 1 chain (HLA-DQA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[133]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[113]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[42]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[74]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[134]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[135]
Capecitabine	DMTS85L	Adenocarcinoma	2D40	Approved	[136]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[119]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[133]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[137]

Drug(s) Affected By Collagen alpha-1(III) chain (COL3A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[138]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[139]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[140]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[141]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[142]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[143]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[144]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[42]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[145]

Drug(s) Affected By HLA class II histocompatibility antigen gamma chain (CD74)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[77]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[146]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[41]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[147]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[148]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[85]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[61]

Drug(s) Affected By HLA class I histocompatibility antigen, A alpha chain (HLA-A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[149]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[150]
Allopurinol	DMLPAOB	Gout	FA25	Approved	[151]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[152]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[153]
Ticlopidine	DMO946V	Acute coronary syndrome	BA41	Approved	[154]
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[153]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[147]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[147]

Drug(s) Affected By Interferon alpha-6 (IFNA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[155]

Drug(s) Affected By Integrin beta-1 (ITGB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[156]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[157]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[158]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[159]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[160]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[161]
Fructose	DM43AN2	Vomiting	MD90	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[163]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[164]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[165]

Drug(s) Affected By Protein kinase C beta type (PRKCB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[77]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[166]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[167]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[112]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[168]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[169]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[86]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[166]

Drug(s) Affected By Insulin receptor (INSR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[170]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[171]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[173]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[174]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[175]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[176]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[177]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[69]

Drug(s) Affected By Cathepsin B (CTSB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[178]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[157]
Selenium	DM25CGV	N. A.	N. A.	Approved	[77]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[60]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[179]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Pyrimethamine	DM5X7VY	Malaria	1F40-1F45	Approved	[180]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[181]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[182]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[183]

Drug(s) Affected By Heat shock protein HSP 90-alpha (HSP90AA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[184]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[156]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[185]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[186]
Selenium	DM25CGV	N. A.	N. A.	Approved	[77]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[187]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[188]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[18]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]

Drug(s) Affected By DNA excision repair protein ERCC-1 (ERCC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[77]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[60]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[190]
Pemetrexed	DMMX2E6	Central nervous system lymphoma	2B33.5	Approved	[191]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[192]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[193]

Drug(s) Affected By Insulin-like growth factor 1 receptor (IGF1R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[194]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[195]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[196]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[197]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[198]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[199]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[200]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[105]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[105]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[72]

Drug(s) Affected By Glutathione S-transferase P (GSTP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[201]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[34]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[202]
Chlorambucil	DMRKE63	Chronic lymphocytic leukaemia	2A82.0	Approved	[202]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[203]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[204]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[159]
Selenium	DM25CGV	N. A.	N. A.	Approved	[77]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[205]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[206]

Drug(s) Affected By Pepsin A-3 (PGA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[47]

Drug(s) Affected By Androgen receptor (AR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[207]
Nilutamide	DMFN07X	Prostate cancer	2C82.0	Approved	[207]
Hydroxyflutamide	DMGIZF5	Prostate cancer	2C82.0	Approved	[207]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[208]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[209]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[210]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[211]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[212]
Selenium	DM25CGV	N. A.	N. A.	Approved	[213]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[214]

Drug(s) Affected By Myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MYL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[215]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[216]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[217]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[119]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[218]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[218]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[51]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[39]

Drug(s) Affected By Heat shock cognate 71 kDa protein (HSPA8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[219]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[220]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[221]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[111]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[205]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[167]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[223]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[18]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[224]

Drug(s) Affected By E3 SUMO-protein ligase EGR2 (EGR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[60]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[225]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[67]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[68]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[55]

Drug(s) Affected By Ornithine decarboxylase (ODC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[226]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[227]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[228]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[229]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[230]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[230]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[231]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[113]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[232]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[233]

Drug(s) Affected By Alpha-actinin-1 (ACTN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[77]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[86]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[61]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[108]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[234]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[35]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[36]

Drug(s) Affected By Cadherin-1 (CDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[157]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[102]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[235]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[236]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[237]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[60]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[163]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[164]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[41]

Drug(s) Affected By Proto-oncogene tyrosine-protein kinase Src (SRC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bosutinib	DMTI8YE	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[238]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[239]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[171]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[240]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[148]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[241]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[242]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[243]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[243]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]

Drug(s) Affected By Tissue factor (F3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[244]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[245]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[246]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[247]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[248]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[249]
Fructose	DM43AN2	Vomiting	MD90	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[250]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[245]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[251]

Drug(s) Affected By HLA class I histocompatibility antigen, alpha chain E (HLA-E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[147]
Clindamycin	DM15HL8	Acne vulgaris	ED80	Approved	[147]
Selenium	DM25CGV	N. A.	N. A.	Approved	[77]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[147]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[147]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[112]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[189]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[225]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[147]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[252]

Drug(s) Affected By HLA class II histocompatibility antigen, DR beta 4 chain (HLA-DRB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[53]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[67]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[92]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[55]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[253]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[254]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[255]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[256]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[257]
Manganese	DMKT129	N. A.	N. A.	Investigative	[258]

Drug(s) Affected By Hepatocyte growth factor (HGF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[159]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[259]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[260]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[261]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[261]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[118]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[262]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[263]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[264]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[265]

Drug(s) Affected By Heat shock 70 kDa protein 6 (HSPA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[266]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[220]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[21]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[188]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[117]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[267]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[163]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[268]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[18]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[86]

Drug(s) Affected By Sphingomyelin phosphodiesterase (SMPD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[198]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[269]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[112]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[270]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[61]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[55]

Drug(s) Affected By General transcription and DNA repair factor IIH helicase subunit XPD (ERCC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[157]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[271]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[61]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[272]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[273]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[274]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[275]

Drug(s) Affected By Alpha-2C adrenergic receptor (ADRA2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[77]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Oxymetazoline	DM8ZXT6	Arrhythmia	BC9Z	Approved	[276]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[277]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[48]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[45]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[88]
Xylometazoline	DMKV32D	Allergic rhinitis	CA08.0	Phase 4	[276]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[49]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[278]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[279]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[53]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[280]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[281]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[282]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[148]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[283]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[284]

Drug(s) Affected By Casein kinase II subunit alpha' (CSNK2A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[64]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[60]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[61]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[69]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[285]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[286]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[287]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[288]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[118]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[284]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[289]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[289]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[101]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[290]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[272]

Drug(s) Affected By Filaggrin (FLG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[291]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[230]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[230]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[292]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[291]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[293]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[294]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[55]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[292]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[230]

Drug(s) Affected By Diamine acetyltransferase 1 (SAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[52]
Selenium	DM25CGV	N. A.	N. A.	Approved	[77]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[295]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[296]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[60]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[112]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[41]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[297]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[297]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[86]

Drug(s) Affected By Protein-glutamine gamma-glutamyltransferase 2 (TGM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[157]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[298]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[299]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[105]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[105]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[300]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[61]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[301]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[302]

Drug(s) Affected By Transcription elongation factor A protein 1 (TCEA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[59]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[159]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[61]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[303]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[57]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[304]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[51]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[39]

Drug(s) Affected By Myosin regulatory light polypeptide 9 (MYL9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[60]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[105]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[105]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[86]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[55]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[35]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[36]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[23]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[157]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[21]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[305]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[306]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[307]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[198]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[308]
Fructose	DM43AN2	Vomiting	MD90	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[157]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[309]

Drug(s) Affected By Moesin (MSN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[77]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[310]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[61]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[311]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[312]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[36]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]

Drug(s) Affected By High mobility group protein B2 (HMGB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[313]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[111]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[60]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[314]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[315]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[105]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[105]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[60]

Drug(s) Affected By Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[316]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[317]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[288]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[98]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[318]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[283]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[252]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[319]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]

Drug(s) Affected By Proteasome subunit beta type-9 (PSMB9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[320]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[112]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[321]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[61]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[322]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[323]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[192]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[320]

Drug(s) Affected By Proteasome subunit beta type-6 (PSMB6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[165]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[324]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[106]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[34]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[35]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[325]
Ardeparin	DMYRX8B	Deep vein thrombosis	BD71	Approved	[326]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[63]

Drug(s) Affected By ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[112]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[327]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[328]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[329]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[330]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[331]
Bortezomib	DMNO38U	Leukemia		Approved	[68]
Omacetaxine mepesuccinate	DMPU2WX	Adult acute monocytic leukemia		Approved	[328]
Novobiocin	DMRFWGK	Bacterial infection	1A00-1C4Z	Approved	[332]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[34]

Drug(s) Affected By S-adenosylmethionine synthase isoform type-2 (MAT2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[333]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[52]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[334]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[112]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[86]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[61]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[335]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[334]

Drug(s) Affected By Heat shock 70 kDa protein 1-like (HSPA1L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[336]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[337]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[16]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[267]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[18]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[61]
Isoproterenol	DMK7MEY	Atrioventricular block		Approved	[338]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Teriflunomide	DMQ2FKJ	Hyperlipidaemia	5C80	Approved	[339]

Drug(s) Affected By Vascular endothelial growth factor receptor 2 (KDR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[340]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[341]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[342]
Haloperidol	DM96SE0	Delirium		Approved	[333]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[333]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[272]
Orlistat	DMRJSP8	Obesity	5B81	Approved	[343]

Drug(s) Affected By Transcription factor 7 (TCF7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[337]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[344]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[252]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[31]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[345]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[32]
Bortezomib	DMNO38U	Leukemia		Approved	[68]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[346]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[116]

Drug(s) Affected By Interleukin-15 (IL15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[347]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[163]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[148]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[348]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[174]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[67]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[349]
Bortezomib	DMNO38U	Leukemia		Approved	[68]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[350]

Drug(s) Affected By Hepatocyte nuclear factor 4-alpha (HNF4A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[351]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[196]
Fructose	DM43AN2	Vomiting	MD90	Approved	[352]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[353]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[354]
SR141716A	DMCO5JZ	Obesity	5B81	Approved	[355]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[356]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[357]
Estriol	DMOEM2I	Hormone deficiency	5A61.1	Approved	[358]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[270]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[359]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[360]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[361]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[362]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[363]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[364]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[365]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[366]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[367]

Drug(s) Affected By Killer cell immunoglobulin-like receptor 2DL3 (KIR2DL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[368]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[87]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[60]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[51]
PMID28870136-Compound-48	DMPIM9L	N. A.	N. A.	Patented	[369]

Drug(s) Affected By Lysophosphatidic acid receptor 6 (LPAR6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[41]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[113]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[370]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[192]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[34]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[371]

Drug(s) Affected By G-protein coupled receptor 4 (GPR4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[116]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[51]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[372]
lysophosphatidylcholine	DMOGFVH	Discovery agent	N.A.	Investigative	[373]

Drug(s) Affected By B1 bradykinin receptor (BDKRB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[105]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[105]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[55]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[277]
Enalaprilat	DMFYAM1	Congestive heart failure	BD10	Approved	[374]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[375]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[376]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[47]
Beclomethasone dipropionate	DM5NW1E	Allergic rhinitis	CA08.0	Phase 4	[377]

Drug(s) Affected By Glioma pathogenesis-related protein 1 (GLIPR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[60]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[225]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[86]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[67]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[68]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[55]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[93]

Drug(s) Affected By Neuropeptides B/W receptor type 1 (NPBWR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[51]

Drug(s) Affected By C-C chemokine receptor type 9 (CCR9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[49]
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[49]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[32]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[256]

Drug(s) Affected By Large ribosomal subunit protein bL12m (MRPL12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[111]
Selenium	DM25CGV	N. A.	N. A.	Approved	[77]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[61]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[378]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[379]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[37]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[77]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[380]

Drug(s) Affected By Diacylglycerol kinase theta (DGKQ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[37]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[381]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[41]

Drug(s) Affected By High mobility group protein HMGI-C (HMGA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[313]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[67]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[61]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[382]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[383]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[384]

Drug(s) Affected By Cysteine-rich secretory protein 1 (CRISP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[51]
Calphostin C	DM9X2D0	N. A.	N. A.	Terminated	[385]

Drug(s) Affected By Myomesin-2 (MYOM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[386]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[217]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[386]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[386]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[387]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[39]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[388]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[59]

Drug(s) Affected By Proteinase-activated receptor 2 (F2RL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[389]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[171]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[60]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[104]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[86]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[390]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[55]

Drug(s) Affected By Adenosine kinase (ADK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[59]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[310]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[252]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[61]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[55]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[391]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[384]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[52]

Drug(s) Affected By P2X purinoceptor 3 (P2RX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[51]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[257]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[392]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[393]

Drug(s) Affected By Claudin-8 (CLDN8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[76]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[394]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[395]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[105]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[105]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[394]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[119]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[396]
Tetracycline	DMZA017	Acne vulgaris	ED80	Approved	[397]

Drug(s) Affected By Cilia- and flagella-associated protein 298 (CFAP298)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[59]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[257]

Drug(s) Affected By Anaphase-promoting complex subunit 15 (ANAPC15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[77]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[86]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[61]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[77]
PEITC	DMOMN31	Prostate cancer	2C82.0	Phase 2	[398]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[399]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[51]

Drug(s) Affected By Ras-related C3 botulinum toxin substrate 3 (RAC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[400]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[163]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[106]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[55]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[32]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[401]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[88]

Drug(s) Affected By Proteasome subunit alpha type-6 (PSMA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[148]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[61]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[52]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[378]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[402]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[403]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[381]
MG-132	DMKA2YS	N. A.	N. A.	Preclinical	[404]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[405]

Drug(s) Affected By Ras-related protein Rap-1A (RAP1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[406]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[221]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[407]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[98]
Minodronate	DM50PMY	Osteoporosis	FB83.0	Approved	[408]
Risedronate	DM5FLTY	Bone Paget disease		Approved	[409]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[410]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Pamidronate	DMB4AVP	Bone Paget disease		Approved	[409]

Drug(s) Affected By Casein kinase II subunit alpha (CSNK2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[77]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[64]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[411]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[64]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[412]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[61]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[413]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]

Drug(s) Affected By Claudin-10 (CLDN10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[157]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[287]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[414]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[293]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[415]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[415]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[416]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[88]
Tetracycline	DMZA017	Acne vulgaris	ED80	Approved	[397]

Drug(s) Affected By Proline-rich protein 3 (PRR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[171]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[105]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[105]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[55]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[417]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[37]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[39]

Drug(s) Affected By b(0,+)-type amino acid transporter 1 (SLC7A9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[60]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[34]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[418]

Drug(s) Affected By Mothers against decapentaplegic homolog 3 (SMAD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[59]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[419]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[420]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[421]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[422]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[423]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[424]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[92]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[425]

Drug(s) Affected By 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 (PLCB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[252]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[273]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[109]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[426]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[426]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[399]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[51]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[39]

Drug(s) Affected By N-acetylgalactosamine kinase (GALK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[112]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[35]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[116]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[427]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[112]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[51]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[39]

Drug(s) Affected By Melanocyte-stimulating hormone receptor (MC1R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[148]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[428]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[429]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[55]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[52]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[37]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[430]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[430]
GUAIACOL	DMN4E7T	N. A.	N. A.	Phase 3	[430]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[430]

Drug(s) Affected By Transcription factor Sp4 (SP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[431]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[431]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[105]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[36]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[88]
Vitamin C	DMXJ7O8	Adenocarcinoma	2D40	Approved	[432]

Drug(s) Affected By CTD small phosphatase-like protein 2 (CTDSPL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[55]
Bortezomib	DMNO38U	Leukemia		Approved	[68]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[34]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[116]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[71]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]

Drug(s) Affected By Rho-associated protein kinase 1 (ROCK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[433]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[434]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[252]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[435]
Pamidronate	DMB4AVP	Bone Paget disease		Approved	[436]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[61]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[437]

Drug(s) Affected By Calcium/calmodulin-dependent protein kinase type II subunit beta (CAMK2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[219]
Selenium	DM25CGV	N. A.	N. A.	Approved	[77]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[163]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[252]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[438]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[61]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[439]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[35]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[440]

Drug(s) Affected By Kelch-like ECH-associated protein 1 (KEAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[441]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[389]
Selenium	DM25CGV	N. A.	N. A.	Approved	[77]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[442]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[443]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[72]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[72]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[444]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[445]

Drug(s) Affected By DAP3-binding cell death enhancer 1 (DELE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]

Drug(s) Affected By Protein-tyrosine kinase 2-beta (PTK2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[446]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[112]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[447]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[448]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[345]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[449]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[35]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[116]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[37]

Drug(s) Affected By Protein FAM50A (FAM50A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[77]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[60]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[116]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[38]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[43]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[39]

Drug(s) Affected By RNA-binding protein 39 (RBM39)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[111]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[36]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[445]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[57]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[450]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[38]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[39]

Drug(s) Affected By Keratin, type II cuticular Hb1 (KRT81)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[92]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[55]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[34]
Orlistat	DMRJSP8	Obesity	5B81	Approved	[451]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[120]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[51]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[59]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[452]

Drug(s) Affected By Caspase-8 (CASP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[453]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[454]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[455]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[156]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[456]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[457]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[305]
Selenium	DM25CGV	N. A.	N. A.	Approved	[77]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[458]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[171]

Drug(s) Affected By Killer cell immunoglobulin-like receptor 2DS5 (KIR2DS5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[87]

Drug(s) Affected By P2Y purinoceptor 6 (P2RY6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[345]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[34]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[459]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[37]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[460]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[461]

Drug(s) Affected By Transcription elongation factor A protein 2 (TCEA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[77]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[53]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[288]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[370]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[415]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[415]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[35]

Drug(s) Affected By Probable G-protein coupled receptor 19 (GPR19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[105]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[105]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[88]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[462]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[463]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[51]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[67]

Drug(s) Affected By Neuropeptide Y receptor type 5 (NPY5R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[174]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[293]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[120]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[51]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[174]

Drug(s) Affected By Occludin (OCLN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[464]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[465]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[466]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[467]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[252]
Thioguanine	DM7NKEV	Acute lymphocytic leukaemia	2B33.3	Approved	[468]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[469]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 3 (CDKN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[347]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[296]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[60]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[470]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[105]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[105]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]

Drug(s) Affected By Schlafen-like protein 1 (SLFNL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[51]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[59]

Drug(s) Affected By Adhesion G-protein coupled receptor F1 (ADGRF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[260]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[119]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[471]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[51]
CH-223191	DMMJZYC	Solid tumour/cancer	2A00-2F9Z	Investigative	[472]

Drug(s) Affected By Early estrogen-induced gene 1 protein (EEIG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[473]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[474]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[55]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[475]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[475]
Estriol	DMOEM2I	Hormone deficiency	5A61.1	Approved	[475]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[34]

Drug(s) Affected By 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2 (OGFOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[273]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[39]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[277]

Drug(s) Affected By Nuclear factor related to kappa-B-binding protein (NFRKB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[35]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[41]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[38]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[476]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[39]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[381]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[381]
4-hydroxy-2-nonenal	DM2LJFZ	Discovery agent	N.A.	Investigative	[159]

Drug(s) Affected By GTPase IMAP family member 6 (GIMAP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[118]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[273]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[36]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]

Drug(s) Affected By INO80 complex subunit C (INO80C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[34]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[37]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[418]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[257]

Drug(s) Affected By Monocarboxylate transporter 13 (SLC16A13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[474]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[477]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[51]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[39]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[478]

Drug(s) Affected By Interferon regulatory factor 2-binding protein 2 (IRF2BP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[282]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[86]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[61]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[282]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[345]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[52]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[36]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[88]

Drug(s) Affected By Adhesion G-protein coupled receptor G6 (ADGRG6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[260]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[36]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[120]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[427]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[479]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[31]

Drug(s) Affected By Junctional adhesion molecule-like (JAML)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[86]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[273]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[52]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[399]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[256]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[59]

Drug(s) Affected By Protein AHNAK2 (AHNAK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[106]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[61]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[92]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[55]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[415]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[415]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[109]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[479]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[480]

Drug(s) Affected By SURP and G-patch domain-containing protein 1 (SUGP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[86]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[55]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[37]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[39]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[381]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[481]

Drug(s) Affected By CD302 antigen (CD302)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[60]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[390]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[382]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[277]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[477]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[45]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[63]

Drug(s) Affected By Protein FAM43A (FAM43A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[29]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[53]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[41]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[395]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[86]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[92]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[345]

Drug(s) Affected By Ceramide synthase 5 (CERS5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[53]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[60]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[183]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[72]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[72]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[55]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[72]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[477]

Drug(s) Affected By tRNA-uridine aminocarboxypropyltransferase 1 (DTWD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[60]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[482]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[370]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[106]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[55]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[34]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[36]

Drug(s) Affected By Acyl-CoA-binding domain-containing protein 7 (ACBD7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[105]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[105]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[86]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[35]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[116]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[37]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[483]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[39]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[481]

Drug(s) Affected By POU domain, class 5, transcription factor 2 (POU5F2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[155]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[387]

Drug(s) Affected By POC1 centriolar protein homolog A (POC1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[105]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[105]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[86]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[273]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[116]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[460]

Drug(s) Affected By Putative RNA-binding protein 15B (RBM15B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[61]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[293]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[55]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[415]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[415]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[37]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[51]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[381]

Drug(s) Affected By PH and SEC7 domain-containing protein 4 (PSD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[60]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[36]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[57]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[399]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[51]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[381]

Drug(s) Affected By Follicular dendritic cell secreted peptide (FDCSP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]

Drug(s) Affected By Tetraspanin-14 (TSPAN14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[77]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[484]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[61]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[293]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[277]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[35]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]

Drug(s) Affected By Proteasome subunit alpha-type 8 (PSMA8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[51]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[59]

Drug(s) Affected By Probable mitochondrial glutathione transporter SLC25A40 (SLC25A40)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[485]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[61]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[68]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[378]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[51]

Drug(s) Affected By Mitochondria-eating protein (SPATA18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[110]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[60]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[55]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[110]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[415]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[415]

Drug(s) Affected By Hepatitis A virus cellular receptor 2 (HAVCR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[148]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[42]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[460]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[486]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[487]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[478]

Drug(s) Affected By Protein FAM216A (FAM216A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[105]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[105]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[55]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[449]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[109]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[37]

Drug(s) Affected By Dimethyladenosine transferase 1, mitochondrial (TFB1M)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[61]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Teriflunomide	DMQ2FKJ	Hyperlipidaemia	5C80	Approved	[339]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[35]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[36]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[31]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[63]

Drug(s) Affected By Adhesion G-protein coupled receptor V1 (ADGRV1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[41]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[370]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[293]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[92]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[55]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[52]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[35]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[479]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[88]

Drug(s) Affected By Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 (ARAP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[41]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[252]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[105]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[67]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[192]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[34]

Drug(s) Affected By Protein FAM3C (FAM3C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[230]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[189]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[61]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[230]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[253]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[273]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[477]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[88]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[63]

Drug(s) Affected By Sortilin-related receptor (SORL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[86]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[72]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[174]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[72]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[72]

Drug(s) Affected By Receptor-type tyrosine-protein phosphatase U (PTPRU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[60]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[421]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[31]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[277]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[34]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[35]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[116]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[488]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[47]

Drug(s) Affected By Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (INPP5D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[415]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[34]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[116]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[57]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[31]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[37]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[41]

Drug(s) Affected By Histone acetyltransferase KAT5 (KAT5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[112]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[489]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[445]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[490]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[491]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[492]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[445]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[112]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[493]

Drug(s) Affected By Claudin-23 (CLDN23)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[52]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[78]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[415]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[415]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[52]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[36]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[41]

Drug(s) Affected By Solute carrier family 22 member 18 (SLC22A18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[52]
Selenium	DM25CGV	N. A.	N. A.	Approved	[77]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[90]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[189]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[168]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[105]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[105]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]

Drug(s) Affected By Metalloendopeptidase OMA1, mitochondrial (OMA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[60]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[302]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[415]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[415]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[36]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[57]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[31]

Drug(s) Affected By P2Y purinoceptor 11 (P2RY11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[494]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[55]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[34]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[48]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[48]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[392]

Drug(s) Affected By Centrosomal protein of 95 kDa (CEP95)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[52]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[38]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[381]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[495]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[381]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[67]

Drug(s) Affected By Fumarylacetoacetate hydrolase domain-containing protein 2A (FAHD2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[104]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[395]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[86]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[61]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[496]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[51]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[497]

Drug(s) Affected By Adhesion G-protein coupled receptor G7 (ADGRG7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[418]

Drug(s) Affected By Inositol polyphosphate-4-phosphatase type I A (INPP4A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[171]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[35]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[116]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[37]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[463]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[51]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[59]

Drug(s) Affected By RING finger and CHY zinc finger domain-containing protein 1 (RCHY1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[77]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[498]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[35]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[57]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[63]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[499]

Drug(s) Affected By Killer cell immunoglobulin-like receptor 2DL4 (KIR2DL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[368]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[87]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[51]

Drug(s) Affected By Endothelial PAS domain-containing protein 1 (EPAS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[500]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[171]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[501]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[442]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[41]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[502]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[86]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ketorolac	DMI4EL5	Postoperative inflammation	1A00-CA43.1	Approved	[502]

Drug(s) Affected By Acyl-CoA-binding domain-containing protein 6 (ACBD6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[60]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[399]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[460]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[277]

Drug(s) Affected By Serine/threonine-protein kinase RIO1 (RIOK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[55]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[109]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[381]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[503]

Drug(s) Affected By Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial (ALKBH7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[61]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[345]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[55]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[35]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[48]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[418]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[71]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[257]

Drug(s) Affected By DCN1-like protein 5 (DCUN1D5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[55]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[109]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[57]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[504]

Drug(s) Affected By Transmembrane protein 208 (TMEM208)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[189]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[415]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[415]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[77]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[51]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[257]

Drug(s) Affected By Ashwin (C2ORF49)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[252]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[61]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[37]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[41]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[60]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[39]

Drug(s) Affected By Sorbin and SH3 domain-containing protein 1 (SORBS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[381]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[189]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[485]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[390]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[67]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[277]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[34]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[114]

Drug(s) Affected By Probable G-protein coupled receptor 174 (GPR174)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[337]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[399]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[51]

Drug(s) Affected By Probable G-protein coupled receptor 63 (GPR63)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[101]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[35]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[109]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[51]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[39]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[67]

Drug(s) Affected By Metal cation symporter ZIP8 (SLC39A8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[163]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[189]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[41]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[505]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[22]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]

Drug(s) Affected By Homeobox protein TGIF2 (TGIF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[60]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[55]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[116]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[48]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[37]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[471]

Drug(s) Affected By NUAK family SNF1-like kinase 2 (NUAK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[53]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[117]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[148]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[86]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[106]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[55]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[35]

Drug(s) Affected By RNA-binding protein 38 (RBM38)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[60]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[106]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[61]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[55]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[384]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[35]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[116]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[47]

Drug(s) Affected By Lysophosphatidic acid receptor 5 (LPAR5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[86]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[37]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[51]

Drug(s) Affected By Tumor protein 63 (TP63)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[59]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[506]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[507]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[508]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[509]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[383]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[510]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[34]

Drug(s) Affected By Thioredoxin-related transmembrane protein 1 (TMX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[252]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[31]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[61]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[511]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[36]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[71]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[71]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[51]

Drug(s) Affected By Ribokinase (RBKS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[60]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[302]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[32]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[36]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[48]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[37]

Drug(s) Affected By Protein eva-1 homolog A (EVA1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[60]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[163]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[81]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[42]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[86]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[92]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[277]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]

Drug(s) Affected By Polyprenol reductase (SRD5A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[72]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[72]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[72]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[72]

Drug(s) Affected By Jupiter microtubule associated homolog 2 (JPT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[53]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[61]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[35]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[31]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[63]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[39]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[512]

Drug(s) Affected By Succinate--hydroxymethylglutarate CoA-transferase (SUGCT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[513]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[34]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[477]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[47]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[37]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[43]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[59]

Drug(s) Affected By p53-induced death domain-containing protein 1 (PIDD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[514]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[78]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[60]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[105]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[105]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[72]

Drug(s) Affected By Neuromedin-U receptor 1 (NMUR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[119]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[51]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[83]

Drug(s) Affected By POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[445]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[293]
Bortezomib	DMNO38U	Leukemia		Approved	[68]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[23]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[88]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[88]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[38]

Drug(s) Affected By Plasminogen receptor (PLGRKT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[156]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[31]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[322]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[116]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[48]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[88]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[37]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[51]

Drug(s) Affected By Cytochrome P450 26B1 (CYP26B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[515]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[370]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[509]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[516]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[517]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[415]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[34]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[35]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[120]

Drug(s) Affected By Thrombospondin type-1 domain-containing protein 1 (THSD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[52]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[34]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[477]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[418]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[497]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[503]

Drug(s) Affected By Probable G-protein coupled receptor 173 (GPR173)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[459]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[119]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[41]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[51]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[39]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[518]

Drug(s) Affected By Fas apoptotic inhibitory molecule 1 (FAIM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[60]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[282]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[86]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[61]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[282]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[277]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]

Drug(s) Affected By Transmembrane protein 242 (TMEM242)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[293]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[51]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[39]

Drug(s) Affected By Large ribosomal subunit protein uL22m (MRPL22)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[52]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[36]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[257]

Drug(s) Affected By Ankyrin repeat and SOCS box protein 6 (ASB6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]

Drug(s) Affected By Transmembrane protein 160 (TMEM160)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[477]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[399]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[39]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[388]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[257]

Drug(s) Affected By Kelch-like protein 28 (KLHL28)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[252]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[67]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[32]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[36]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[88]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[37]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[51]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[67]

Drug(s) Affected By G-protein coupled receptor 83 (GPR83)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[119]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[462]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[51]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[372]

Drug(s) Affected By Cadherin EGF LAG seven-pass G-type receptor 3 (CELSR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[111]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[519]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[55]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[449]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[34]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[35]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[51]

Drug(s) Affected By RB-associated KRAB zinc finger protein (RBAK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[88]
Fenretinide	DMRD5SP	Macular degeneration	9B78.3	Phase 3	[520]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[38]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[39]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[495]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[503]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[174]

Drug(s) Affected By Ubiquinone biosynthesis O-methyltransferase, mitochondrial (COQ3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[60]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[105]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[105]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[34]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[378]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[88]

Drug(s) Affected By 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 (PLCE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[106]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[52]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[35]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[521]
Capecitabine	DMTS85L	Adenocarcinoma	2D40	Approved	[521]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[522]

Drug(s) Affected By P2X purinoceptor 2 (P2RX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[523]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[37]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[51]

Drug(s) Affected By E3 ubiquitin-protein ligase RNF14 (RNF14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[60]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[31]
Bortezomib	DMNO38U	Leukemia		Approved	[68]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[415]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[415]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[36]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[488]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[37]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[51]

Drug(s) Affected By Lysophosphatidic acid receptor 3 (LPAR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[35]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[119]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[375]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[88]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[47]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[524]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[41]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[51]

Drug(s) Affected By ATP-binding cassette sub-family F member 2 (ABCF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[52]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[53]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[31]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[61]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[35]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[109]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[38]

Drug(s) Affected By SERTA domain-containing protein 1 (SERTAD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[60]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[163]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[81]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[72]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[72]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[67]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[72]

Drug(s) Affected By Lymphoid enhancer-binding factor 1 (LEF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[525]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[526]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[527]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[528]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Adenosine	DMM2NSK	Paroxysmal supraventricular tachycardia	BC81.Z	Approved	[529]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[346]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[530]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[88]

Drug(s) Affected By Protein O-mannosyl-transferase 2 (POMT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[523]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[476]

Drug(s) Affected By Malignant T-cell-amplified sequence 1 (MCTS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[111]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[53]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[189]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[148]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[61]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[522]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[531]

Drug(s) Affected By Frizzled-4 (FZD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[86]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[532]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[55]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[277]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[69]

Drug(s) Affected By ATP-dependent RNA helicase DDX19B (DDX19B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[252]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[35]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[51]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[257]

Drug(s) Affected By Serine/arginine repetitive matrix protein 2 (SRRM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[111]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[381]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[200]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[445]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[61]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[333]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[55]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[273]

Drug(s) Affected By Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[370]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[61]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[116]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[533]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[524]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[37]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[534]

Drug(s) Affected By DNA polymerase eta (POLH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[369]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[60]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[200]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[86]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[101]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[67]
Lomustine	DMMWSUL	Brain cancer	2A00	Approved	[535]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[535]

Drug(s) Affected By Lysine-specific demethylase 3A (KDM3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[389]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[536]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[60]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[282]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[148]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[86]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[72]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]

Drug(s) Affected By Neuropeptide FF receptor 2 (NPFFR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[92]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[31]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[41]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[41]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[51]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[59]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[174]

Drug(s) Affected By Prostaglandin D2 receptor 2 (PTGDR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[118]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[86]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[34]
Indomethacin	DMSC4A7	Bursitis		Approved	[537]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[538]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[539]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[37]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[51]

Drug(s) Affected By Peroxisomal membrane protein PEX16 (PEX16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[189]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[55]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[77]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[39]

Drug(s) Affected By Junctional adhesion molecule A (F11R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[59]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[52]
Selenium	DM25CGV	N. A.	N. A.	Approved	[77]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[61]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[217]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[34]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]

Drug(s) Affected By Adhesion G-protein coupled receptor G1 (ADGRG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[60]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[41]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[42]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[86]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[540]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[541]

Drug(s) Affected By Dehydrogenase/reductase SDR family member 11 (DHRS11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[542]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[542]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Flufenamic Acid	DMC8VNH	Dysmenorrhea	GA34.3	Approved	[542]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[67]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[92]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[55]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Aldose reductase (AKR1B1)	TTFBNVI	ALDR_HUMAN	Inhibitor	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 (PLCB2)	OTPAHDGO	PLCB2_HUMAN	Gene/Protein Processing	[2]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 (PLCE1)	OTJISZOX	PLCE1_HUMAN	Gene/Protein Processing	[2]
2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2 (OGFOD2)	OTTXP61X	OGFD2_HUMAN	Gene/Protein Processing	[2]
Actin nucleation-promoting factor WAS	OTD03E8M	WASP_HUMAN	Gene/Protein Processing	[2]
Acyl-CoA-binding domain-containing protein 6 (ACBD6)	OTF3XXNI	ACBD6_HUMAN	Gene/Protein Processing	[2]
Acyl-CoA-binding domain-containing protein 7 (ACBD7)	OTTY4K6K	ACBD7_HUMAN	Gene/Protein Processing	[2]
Adenosine kinase (ADK)	OTXR6VDI	ADK_HUMAN	Gene/Protein Processing	[2]
Adhesion G protein-coupled receptor B1 (ADGRB1)	OTJSEXRC	AGRB1_HUMAN	Gene/Protein Processing	[2]
Adhesion G-protein coupled receptor F1 (ADGRF1)	OTRAOBYH	AGRF1_HUMAN	Gene/Protein Processing	[2]
Adhesion G-protein coupled receptor G1 (ADGRG1)	OTQBB8NT	AGRG1_HUMAN	Gene/Protein Processing	[2]

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