Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM1DH96)

• Drug Name: QUERCITRIN Drug Info
• Synonyms: quercitrin; 522-12-3; Quercetrin; Quercetin 3-rhamnoside; Quercitroside; Quercimelin; Thujin; Quercetin 3-L-rhamnoside; Quercitronic acid; Quercetin 3-O-rhamnoside; UNII-2Y8906LC5P; CHEBI:17558; Quercetin 3-O-alpha-L-rhamnoside; Quercetin-3-L-rhamnoside; 3,3',4',5,7-Pentahydroxyflavone-3-L-rhamnoside; Quercetin-3-rhamnoside; NSC9221; Quercetin, 3-(6-deoxy-alpha-L-mannopyranoside); 2Y8906LC5P; Mannopyranoside, quercetin-3 6-deoxy-, alpha-L-; Quercetin 3-O-alpha-rhamnopyranoside; Usaf cf-2; Quercetrin-3-O-rham

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 5280459
  ChEBI ID: CHEMBL82242
  CAS Number: CAS 522-12-3
  TTD Drug ID: DM1DH96

Molecule-Related Drug Atlas

Drug(s) Targeting Aldose reductase (AKR1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Epalrestat	DM5OGK0	Diabetic neuropathy	8C0Z	Approved	[3]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[4]
Fidarestat	DMZL1I8	Diabetic complication	5A2Y	Phase 3	[5]
Ranirestat	DMD5QRS	Diabetic neuropathy	8C0Z	Phase 3	[6]
CONTIGOSIDE B	DMX9V8K	Thrombosis	DB61-GB90	Phase 2/3	[7]
BNV-222	DMYFQJL	Diabetic neuropathy	8C0Z	Phase 2/3	[6]
BNV-222	DMYFQJL	Diabetic neuropathy	8C0Z	Phase 2/3	[8]
LIDORESTAT	DMA0RI9	Diabetic complication	5A2Y	Phase 2	[9]
QR-333	DMKVIWM	Diabetic neuropathy	8C0Z	Phase 2	[10]
ADMVA	DM819CO	Diabetic complication	5A2Y	Phase 2	[6]

Drug(s) Affected By ERI1 exoribonuclease 2 (ERI2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[11]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[12]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[13]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[14]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[15]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[16]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[17]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[18]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[19]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[20]

Drug(s) Affected By DNA-directed RNA polymerase, mitochondrial (POLRMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[17]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[22]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[23]
Zalcitabine	DMH7MUV	Human immunodeficiency virus infection	1C62	Approved	[23]
Didanosine	DMI2QPE	Human immunodeficiency virus infection	1C62	Approved	[23]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[22]
INX-189	DMSTJ6Q	Hepatitis C virus infection	1E51.1	Phase 2	[24]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[25]

Drug(s) Affected By C-C chemokine receptor-like 2 (CCRL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[26]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[27]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[31]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[32]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[33]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[34]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[25]

Drug(s) Affected By Histone deacetylase complex subunit SAP18 (SAP18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[35]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[11]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[37]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[38]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[39]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[18]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[19]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[25]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[20]

Drug(s) Affected By Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (PIK3C2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[40]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[43]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[44]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[14]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[45]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[46]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[17]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[47]

Drug(s) Affected By Golgi integral membrane protein 4 (GOLIM4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[49]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[49]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[50]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[37]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[49]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[14]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[49]

Drug(s) Affected By Chromodomain-helicase-DNA-binding protein 2 (CHD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[52]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[53]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[37]
Bortezomib	DMNO38U	Leukemia		Approved	[44]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[55]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[56]

Drug(s) Affected By Monocarboxylate transporter 5 (SLC16A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[57]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[58]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[60]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[61]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[62]

Drug(s) Affected By ATP-binding cassette sub-family C member 4 (ABCC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[63]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[64]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[65]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[66]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[67]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[68]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[69]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[70]

Drug(s) Affected By Zinc finger protein SNAI2 (SNAI2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[71]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[59]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[73]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[74]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[74]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[75]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]

Drug(s) Affected By Alpha-actinin-4 (ACTN4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[76]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[77]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[37]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[78]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[79]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[80]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[76]

Drug(s) Affected By Integral membrane protein GPR137B (GPR137B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[76]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[57]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[81]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[74]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[43]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]

Drug(s) Affected By Protein O-GlcNAcase (OGA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[84]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[43]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[37]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[17]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[47]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[18]

Drug(s) Affected By Galanin receptor type 3 (GALR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[85]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[76]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[25]

Drug(s) Affected By Splicing factor 3B subunit 1 (SF3B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[82]
Selenium	DM25CGV	N. A.	N. A.	Approved	[76]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[86]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[37]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[87]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[39]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[76]

Drug(s) Affected By Gamma-aminobutyric acid type B receptor subunit 2 (GABBR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[88]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[89]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[16]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[90]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[91]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[12]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[59]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[25]

Drug(s) Affected By Ubiquitin-like modifier-activating enzyme ATG7 (ATG7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[92]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[93]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[94]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[67]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[95]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[96]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[97]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[67]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[98]

Drug(s) Affected By Quinone oxidoreductase-like protein 1 (CRYZL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[37]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[14]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[80]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[56]
methyl p-hydroxybenzoate	DMO58UW	Discovery agent	N.A.	Investigative	[99]

Drug(s) Affected By Interferon alpha-1/13 (IFNA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[100]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[101]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[102]
PMID28870136-Compound-48	DMPIM9L	N. A.	N. A.	Patented	[103]

Drug(s) Affected By HLA class II histocompatibility antigen, DQ alpha 1 chain (HLA-DQA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[104]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[84]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[105]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[51]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[106]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[107]
Capecitabine	DMTS85L	Adenocarcinoma	2D40	Approved	[108]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[90]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[104]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[109]

Drug(s) Affected By Collagen alpha-1(III) chain (COL3A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[110]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[111]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[112]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[113]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[114]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[115]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[116]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[105]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[117]

Drug(s) Affected By HLA class II histocompatibility antigen gamma chain (CD74)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[76]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[118]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[59]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[119]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[120]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[53]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[11]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[37]

Drug(s) Affected By Interferon alpha-6 (IFNA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[121]

Drug(s) Affected By Heat shock protein HSP 90-alpha (HSP90AA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[122]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[123]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[124]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[125]
Selenium	DM25CGV	N. A.	N. A.	Approved	[76]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[126]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[127]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[128]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]

Drug(s) Affected By DNA excision repair protein ERCC-1 (ERCC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[76]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[129]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[130]
Pemetrexed	DMMX2E6	Central nervous system lymphoma	2B33.5	Approved	[131]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[132]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[14]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[133]

Drug(s) Affected By Pepsin A-3 (PGA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[33]

Drug(s) Affected By Myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MYL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[135]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[136]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[90]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[137]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[137]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[25]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[20]

Drug(s) Affected By Heat shock cognate 71 kDa protein (HSPA8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[138]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[139]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[140]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[82]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[141]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[142]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[143]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[144]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[128]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[145]

Drug(s) Affected By E3 SUMO-protein ligase EGR2 (EGR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[26]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[146]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[147]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[43]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[44]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]

Drug(s) Affected By Alpha-actinin-1 (ACTN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[76]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[37]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[78]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[14]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[148]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[16]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[17]

Drug(s) Affected By Cadherin-1 (CDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[149]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[71]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[150]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[151]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[152]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[153]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[155]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[59]

Drug(s) Affected By Proto-oncogene tyrosine-protein kinase Src (SRC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bosutinib	DMTI8YE	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[156]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[157]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[158]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[159]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[120]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[160]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[161]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[162]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[162]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]

Drug(s) Affected By HLA class I histocompatibility antigen, alpha chain E (HLA-E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[119]
Clindamycin	DM15HL8	Acne vulgaris	ED80	Approved	[119]
Selenium	DM25CGV	N. A.	N. A.	Approved	[76]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[119]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[119]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[129]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[146]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[119]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[163]

Drug(s) Affected By HLA class II histocompatibility antigen, DR beta 4 chain (HLA-DRB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[27]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[43]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[61]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[164]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[165]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[166]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[167]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[168]
Manganese	DMKT129	N. A.	N. A.	Investigative	[169]

Drug(s) Affected By Heat shock 70 kDa protein 6 (HSPA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[170]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[139]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[171]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[127]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[88]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[172]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[173]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[128]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[54]

Drug(s) Affected By General transcription and DNA repair factor IIH helicase subunit XPD (ERCC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[149]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[174]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[11]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[37]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[175]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[176]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[177]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[80]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[178]

Drug(s) Affected By Alpha-2C adrenergic receptor (ADRA2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[76]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[179]
Oxymetazoline	DM8ZXT6	Arrhythmia	BC9Z	Approved	[180]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[181]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[14]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[22]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[182]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[56]
Xylometazoline	DMKV32D	Allergic rhinitis	CA08.0	Phase 4	[180]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[23]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[183]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[184]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[27]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[185]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[186]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[187]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[120]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[188]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[189]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[190]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[191]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[192]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[89]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[189]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[193]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[193]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[70]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[194]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[175]

Drug(s) Affected By Filaggrin (FLG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[195]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[196]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[196]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[195]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[198]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[199]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[197]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[196]

Drug(s) Affected By Diamine acetyltransferase 1 (SAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[26]
Selenium	DM25CGV	N. A.	N. A.	Approved	[76]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[200]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[201]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[59]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[202]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[202]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[54]

Drug(s) Affected By Protein-glutamine gamma-glutamyltransferase 2 (TGM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[149]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[203]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[204]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[74]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[37]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[206]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[207]

Drug(s) Affected By Transcription elongation factor A protein 1 (TCEA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[35]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[208]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[37]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[14]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[209]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[32]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[210]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[25]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[20]

Drug(s) Affected By Myosin regulatory light polypeptide 9 (MYL9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[74]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[74]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[16]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[17]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[211]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[149]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[171]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[212]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[213]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[214]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[215]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[216]
Fructose	DM43AN2	Vomiting	MD90	Approved	[217]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[218]

Drug(s) Affected By Moesin (MSN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[76]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[219]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[37]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[220]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[221]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[17]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[80]

Drug(s) Affected By Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[222]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[223]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[192]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[179]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[67]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[224]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[188]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[163]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[225]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]

Drug(s) Affected By Proteasome subunit beta type-9 (PSMB9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[226]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[105]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[227]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[37]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[228]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[229]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[132]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[226]

Drug(s) Affected By Proteasome subunit beta type-6 (PSMB6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[230]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[231]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[75]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[37]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[15]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[16]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[80]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[232]
Ardeparin	DMYRX8B	Deep vein thrombosis	BD71	Approved	[233]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[39]

Drug(s) Affected By Heat shock 70 kDa protein 1-like (HSPA1L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[234]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[235]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[236]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[172]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[128]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[37]
Isoproterenol	DMK7MEY	Atrioventricular block		Approved	[237]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[14]
Teriflunomide	DMQ2FKJ	Hyperlipidaemia	5C80	Approved	[238]

Drug(s) Affected By Transcription factor 7 (TCF7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[235]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[239]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[163]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[12]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[240]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[13]
Bortezomib	DMNO38U	Leukemia		Approved	[44]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[14]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[241]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[87]

Drug(s) Affected By Killer cell immunoglobulin-like receptor 2DL3 (KIR2DL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[242]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[55]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[36]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[25]
PMID28870136-Compound-48	DMPIM9L	N. A.	N. A.	Patented	[243]

Drug(s) Affected By G-protein coupled receptor 4 (GPR4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[87]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[25]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[244]
lysophosphatidylcholine	DMOGFVH	Discovery agent	N.A.	Investigative	[245]

Drug(s) Affected By Neuropeptides B/W receptor type 1 (NPBWR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[25]

Drug(s) Affected By Large ribosomal subunit protein bL12m (MRPL12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[82]
Selenium	DM25CGV	N. A.	N. A.	Approved	[76]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[37]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[14]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[246]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[247]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[18]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[76]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[248]

Drug(s) Affected By Diacylglycerol kinase theta (DGKQ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[18]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[249]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[59]

Drug(s) Affected By Cysteine-rich secretory protein 1 (CRISP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[25]
Calphostin C	DM9X2D0	N. A.	N. A.	Terminated	[250]

Drug(s) Affected By Myomesin-2 (MYOM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[251]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[136]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[251]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[251]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[252]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[20]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[253]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[35]

Drug(s) Affected By Claudin-8 (CLDN8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[254]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[255]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[256]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[74]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[74]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[255]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[90]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[257]
Tetracycline	DMZA017	Acne vulgaris	ED80	Approved	[258]

Drug(s) Affected By Cilia- and flagella-associated protein 298 (CFAP298)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[14]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[35]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[168]

Drug(s) Affected By Anaphase-promoting complex subunit 15 (ANAPC15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[76]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[37]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[80]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[76]
PEITC	DMOMN31	Prostate cancer	2C82.0	Phase 2	[259]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[260]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[25]

Drug(s) Affected By Ras-related C3 botulinum toxin substrate 3 (RAC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[261]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[75]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[13]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[14]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[262]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[80]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[56]

Drug(s) Affected By Proteasome subunit alpha type-6 (PSMA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[120]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[37]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[26]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[246]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[263]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[264]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[249]
MG-132	DMKA2YS	N. A.	N. A.	Preclinical	[265]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[266]

Drug(s) Affected By Ras-related protein Rap-1A (RAP1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[267]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[140]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[268]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[67]
Minodronate	DM50PMY	Osteoporosis	FB83.0	Approved	[269]
Risedronate	DM5FLTY	Bone Paget disease		Approved	[270]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[271]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[11]
Pamidronate	DMB4AVP	Bone Paget disease		Approved	[270]

Drug(s) Affected By Casein kinase II subunit alpha (CSNK2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[76]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[40]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[272]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[40]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[273]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[37]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[274]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[14]

Drug(s) Affected By Claudin-10 (CLDN10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[149]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[191]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[275]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[198]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[276]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[276]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[277]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[56]
Tetracycline	DMZA017	Acne vulgaris	ED80	Approved	[258]

Drug(s) Affected By Proline-rich protein 3 (PRR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[158]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[74]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[74]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[80]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[278]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[18]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[20]

Drug(s) Affected By b(0,+)-type amino acid transporter 1 (SLC7A9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[14]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[15]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[279]

Drug(s) Affected By 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 (PLCB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[163]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[176]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[79]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[80]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[280]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[280]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[260]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[25]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[20]

Drug(s) Affected By N-acetylgalactosamine kinase (GALK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[16]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[87]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[281]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[83]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[25]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[20]

Drug(s) Affected By Melanocyte-stimulating hormone receptor (MC1R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[120]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[282]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[283]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[26]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[18]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[284]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[284]
GUAIACOL	DMN4E7T	N. A.	N. A.	Phase 3	[284]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[284]

Drug(s) Affected By Transcription factor Sp4 (SP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[285]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[285]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[74]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[17]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[80]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[56]
Vitamin C	DMXJ7O8	Adenocarcinoma	2D40	Approved	[286]

Drug(s) Affected By CTD small phosphatase-like protein 2 (CTDSPL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[11]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Bortezomib	DMNO38U	Leukemia		Approved	[44]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[14]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[15]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[87]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[47]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[80]

Drug(s) Affected By Calcium/calmodulin-dependent protein kinase type II subunit beta (CAMK2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[138]
Selenium	DM25CGV	N. A.	N. A.	Approved	[76]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[163]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[287]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[37]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[288]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[16]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[289]

Drug(s) Affected By Kelch-like ECH-associated protein 1 (KEAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[290]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[291]
Selenium	DM25CGV	N. A.	N. A.	Approved	[76]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[292]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[293]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[49]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[49]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[294]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[295]

Drug(s) Affected By DAP3-binding cell death enhancer 1 (DELE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[80]

Drug(s) Affected By Protein-tyrosine kinase 2-beta (PTK2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[296]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[297]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[298]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[240]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[299]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[16]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[87]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[80]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[18]

Drug(s) Affected By Protein FAM50A (FAM50A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[76]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[37]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[87]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[80]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[19]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[29]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[20]

Drug(s) Affected By RNA-binding protein 39 (RBM39)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[14]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[17]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[295]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[32]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[300]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[19]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[20]

Drug(s) Affected By Keratin, type II cuticular Hb1 (KRT81)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[11]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[61]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[15]
Orlistat	DMRJSP8	Obesity	5B81	Approved	[301]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[91]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[25]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[35]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[302]

Drug(s) Affected By Killer cell immunoglobulin-like receptor 2DS5 (KIR2DS5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[55]

Drug(s) Affected By Transcription elongation factor A protein 2 (TCEA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[76]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[27]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[192]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[303]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[11]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[14]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[276]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[276]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[16]

Drug(s) Affected By Probable G-protein coupled receptor 19 (GPR19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[74]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[56]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[304]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[305]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[25]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[43]

Drug(s) Affected By Occludin (OCLN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[306]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[307]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[308]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[309]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[163]
Thioguanine	DM7NKEV	Acute lymphocytic leukaemia	2B33.3	Approved	[310]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[311]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 3 (CDKN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[312]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[201]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[88]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[313]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[74]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]

Drug(s) Affected By Schlafen-like protein 1 (SLFNL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[25]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[35]

Drug(s) Affected By Adhesion G-protein coupled receptor F1 (ADGRF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[314]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[179]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[61]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[14]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[90]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[315]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[25]
CH-223191	DMMJZYC	Solid tumour/cancer	2A00-2F9Z	Investigative	[316]

Drug(s) Affected By Early estrogen-induced gene 1 protein (EEIG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[317]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[318]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[319]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[319]
Estriol	DMOEM2I	Hormone deficiency	5A61.1	Approved	[319]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[14]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[15]

Drug(s) Affected By 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2 (OGFOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[14]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[176]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[20]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[181]

Drug(s) Affected By Nuclear factor related to kappa-B-binding protein (NFRKB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[208]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[16]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[59]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[19]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[320]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[20]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[249]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[249]
4-hydroxy-2-nonenal	DM2LJFZ	Discovery agent	N.A.	Investigative	[208]

Drug(s) Affected By GTPase IMAP family member 6 (GIMAP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[89]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[176]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[17]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[80]

Drug(s) Affected By INO80 complex subunit C (INO80C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[15]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[18]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[279]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[168]

Drug(s) Affected By Monocarboxylate transporter 13 (SLC16A13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[318]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[321]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[25]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[20]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[322]

Drug(s) Affected By Interferon regulatory factor 2-binding protein 2 (IRF2BP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[187]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[37]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[187]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[240]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[26]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[17]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[80]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[56]

Drug(s) Affected By Adhesion G-protein coupled receptor G6 (ADGRG6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[314]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[11]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[14]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[17]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[91]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[281]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[323]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[12]

Drug(s) Affected By Junctional adhesion molecule-like (JAML)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[11]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[176]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[26]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[260]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[167]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[35]

Drug(s) Affected By Protein AHNAK2 (AHNAK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[75]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[37]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[61]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[276]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[276]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[79]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[323]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[324]

Drug(s) Affected By SURP and G-patch domain-containing protein 1 (SUGP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[14]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[80]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[18]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[20]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[249]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[325]

Drug(s) Affected By CD302 antigen (CD302)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[326]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[327]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[181]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[14]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[321]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[182]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[80]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[39]

Drug(s) Affected By Protein FAM43A (FAM43A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[328]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[27]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[59]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[256]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[61]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[240]

Drug(s) Affected By Ceramide synthase 5 (CERS5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[27]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[329]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[49]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[49]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[49]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[49]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[321]

Drug(s) Affected By tRNA-uridine aminocarboxypropyltransferase 1 (DTWD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[330]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[303]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[75]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[14]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[15]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[17]

Drug(s) Affected By Acyl-CoA-binding domain-containing protein 7 (ACBD7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[74]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[74]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[54]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[16]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[87]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[18]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[331]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[20]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[325]

Drug(s) Affected By POU domain, class 5, transcription factor 2 (POU5F2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[121]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[252]

Drug(s) Affected By POC1 centriolar protein homolog A (POC1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[74]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[74]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[11]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[14]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[176]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[87]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[332]

Drug(s) Affected By Putative RNA-binding protein 15B (RBM15B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[11]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[37]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[198]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[276]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[276]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[18]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[25]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[249]

Drug(s) Affected By PH and SEC7 domain-containing protein 4 (PSD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[17]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[80]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[32]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[260]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[25]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[249]

Drug(s) Affected By Follicular dendritic cell secreted peptide (FDCSP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]

Drug(s) Affected By Tetraspanin-14 (TSPAN14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[76]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[179]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[333]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[11]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[37]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[198]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[181]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[16]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[80]

Drug(s) Affected By Proteasome subunit alpha-type 8 (PSMA8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[25]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[35]

Drug(s) Affected By Probable mitochondrial glutathione transporter SLC25A40 (SLC25A40)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[334]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[37]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[44]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[14]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[246]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[80]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[25]

Drug(s) Affected By Mitochondria-eating protein (SPATA18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[81]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[11]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[81]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[14]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[276]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[276]

Drug(s) Affected By Hepatitis A virus cellular receptor 2 (HAVCR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[120]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[105]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[332]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[335]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[336]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[322]

Drug(s) Affected By Protein FAM216A (FAM216A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[74]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[299]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[14]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[79]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[18]

Drug(s) Affected By Dimethyladenosine transferase 1, mitochondrial (TFB1M)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[37]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[14]
Teriflunomide	DMQ2FKJ	Hyperlipidaemia	5C80	Approved	[238]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[16]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[17]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[80]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[12]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[39]

Drug(s) Affected By Adhesion G-protein coupled receptor V1 (ADGRV1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[59]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[303]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[198]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[61]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[26]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[16]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[323]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[56]

Drug(s) Affected By Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 (ARAP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[59]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[163]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[43]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[132]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[15]

Drug(s) Affected By Protein FAM3C (FAM3C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[196]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[37]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[196]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[164]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[176]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[321]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[56]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[39]

Drug(s) Affected By Sortilin-related receptor (SORL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[49]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[54]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[49]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[49]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[337]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[49]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[49]

Drug(s) Affected By Receptor-type tyrosine-protein phosphatase U (PTPRU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[338]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[147]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[12]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[181]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[15]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[16]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[87]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[339]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[33]

Drug(s) Affected By Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (INPP5D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[179]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[14]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[276]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[15]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[87]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[32]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[12]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[18]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[59]

Drug(s) Affected By Histone acetyltransferase KAT5 (KAT5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[340]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[11]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[295]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[341]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[342]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[343]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[295]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[83]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[344]

Drug(s) Affected By Claudin-23 (CLDN23)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[26]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[345]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[14]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[276]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[276]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[26]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[17]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[59]

Drug(s) Affected By Solute carrier family 22 member 18 (SLC22A18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[26]
Selenium	DM25CGV	N. A.	N. A.	Approved	[76]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[179]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[58]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[129]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[346]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[74]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]

Drug(s) Affected By Metalloendopeptidase OMA1, mitochondrial (OMA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[207]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[14]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[276]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[276]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[17]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[32]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[12]

Drug(s) Affected By Centrosomal protein of 95 kDa (CEP95)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[26]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[80]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[19]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[249]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[347]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[249]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[43]

Drug(s) Affected By Fumarylacetoacetate hydrolase domain-containing protein 2A (FAHD2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[73]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[256]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[37]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[348]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[25]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[349]

Drug(s) Affected By Adhesion G-protein coupled receptor G7 (ADGRG7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[279]

Drug(s) Affected By RING finger and CHY zinc finger domain-containing protein 1 (RCHY1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[76]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[350]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[11]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[14]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[16]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[32]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[39]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[351]

Drug(s) Affected By Killer cell immunoglobulin-like receptor 2DL4 (KIR2DL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[242]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[55]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[25]

Drug(s) Affected By Endothelial PAS domain-containing protein 1 (EPAS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[352]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[158]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[353]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[292]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[59]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[354]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Ketorolac	DMI4EL5	Postoperative inflammation	1A00-CA43.1	Approved	[354]

Drug(s) Affected By Acyl-CoA-binding domain-containing protein 6 (ACBD6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[260]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[332]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[181]

Drug(s) Affected By Serine/threonine-protein kinase RIO1 (RIOK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[147]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[79]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[249]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[355]

Drug(s) Affected By Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial (ALKBH7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[37]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[240]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[16]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[22]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[279]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[47]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[168]

Drug(s) Affected By DCN1-like protein 5 (DCUN1D5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[79]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[80]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[32]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[356]

Drug(s) Affected By Transmembrane protein 208 (TMEM208)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[129]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[147]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[276]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[276]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[80]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[76]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[25]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[168]

Drug(s) Affected By Ashwin (C2ORF49)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[163]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[37]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[14]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[80]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[18]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[59]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[36]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[20]

Drug(s) Affected By Sorbin and SH3 domain-containing protein 1 (SORBS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[249]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[129]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[334]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[326]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[43]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[181]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[15]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[85]

Drug(s) Affected By Probable G-protein coupled receptor 174 (GPR174)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[235]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[260]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[25]

Drug(s) Affected By Probable G-protein coupled receptor 63 (GPR63)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[70]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[16]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[79]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[80]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[25]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[20]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[43]

Drug(s) Affected By Metal cation symporter ZIP8 (SLC39A8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[129]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[59]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[357]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[61]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[14]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[358]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[80]

Drug(s) Affected By Homeobox protein TGIF2 (TGIF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[11]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[14]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[87]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[22]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[18]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[315]

Drug(s) Affected By RNA-binding protein 38 (RBM38)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[75]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[37]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[359]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[16]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[87]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[33]

Drug(s) Affected By Tumor protein 63 (TP63)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[35]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[360]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[361]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[362]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[363]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[364]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[14]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[365]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[15]

Drug(s) Affected By Thioredoxin-related transmembrane protein 1 (TMX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[163]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[11]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[12]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[37]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[366]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[17]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[47]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[80]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[47]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[25]

Drug(s) Affected By Ribokinase (RBKS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[26]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[129]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[11]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[207]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[13]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[14]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[17]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[22]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[18]

Drug(s) Affected By Protein eva-1 homolog A (EVA1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[147]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[105]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[61]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[181]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[14]

Drug(s) Affected By Polyprenol reductase (SRD5A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[49]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[49]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[49]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[49]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[14]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[49]

Drug(s) Affected By Jupiter microtubule associated homolog 2 (JPT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[27]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[11]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[37]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[16]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[80]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[12]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[39]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[20]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[367]

Drug(s) Affected By Succinate--hydroxymethylglutarate CoA-transferase (SUGCT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[368]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[61]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[14]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[15]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[321]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[33]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[18]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[29]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[35]

Drug(s) Affected By p53-induced death domain-containing protein 1 (PIDD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[369]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[345]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[74]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[74]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[49]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[49]

Drug(s) Affected By POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[295]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[198]
Bortezomib	DMNO38U	Leukemia		Approved	[44]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[14]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[211]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[80]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[56]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[56]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[19]

Drug(s) Affected By Plasminogen receptor (PLGRKT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[123]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[11]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[12]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[228]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[14]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[87]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[22]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[56]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[18]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[25]

Drug(s) Affected By Cytochrome P450 26B1 (CYP26B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[370]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[303]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[363]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[371]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[372]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[14]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[276]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[15]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[16]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[91]

Drug(s) Affected By Thrombospondin type-1 domain-containing protein 1 (THSD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[26]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[14]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[15]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[321]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[279]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[349]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[355]

Drug(s) Affected By Probable G-protein coupled receptor 173 (GPR173)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[373]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[90]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[59]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[25]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[20]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[374]

Drug(s) Affected By Fas apoptotic inhibitory molecule 1 (FAIM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[187]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[11]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[37]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[187]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[181]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[14]

Drug(s) Affected By Transmembrane protein 242 (TMEM242)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[198]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[80]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[25]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[20]

Drug(s) Affected By Large ribosomal subunit protein uL22m (MRPL22)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[26]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[37]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[17]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[168]

Drug(s) Affected By Ankyrin repeat and SOCS box protein 6 (ASB6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[80]

Drug(s) Affected By Transmembrane protein 160 (TMEM160)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[37]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[321]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[260]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[20]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[253]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[168]

Drug(s) Affected By Kelch-like protein 28 (KLHL28)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[163]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[11]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[43]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[13]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[17]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[56]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[18]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[25]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[43]

Drug(s) Affected By G-protein coupled receptor 83 (GPR83)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[90]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[304]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[25]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[244]

Drug(s) Affected By Cadherin EGF LAG seven-pass G-type receptor 3 (CELSR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[375]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[299]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[15]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[16]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[80]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[25]

Drug(s) Affected By RB-associated KRAB zinc finger protein (RBAK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[14]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[80]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[56]
Fenretinide	DMRD5SP	Macular degeneration	9B78.3	Phase 3	[376]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[19]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[20]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[347]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[355]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[337]

Drug(s) Affected By Ubiquinone biosynthesis O-methyltransferase, mitochondrial (COQ3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[74]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[61]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[14]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[15]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[246]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[56]

Drug(s) Affected By 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 (PLCE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[75]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[26]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[16]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[80]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[377]
Capecitabine	DMTS85L	Adenocarcinoma	2D40	Approved	[377]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[378]

Drug(s) Affected By P2X purinoceptor 2 (P2RX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[379]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[18]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[25]

Drug(s) Affected By E3 ubiquitin-protein ligase RNF14 (RNF14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[11]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[12]
Bortezomib	DMNO38U	Leukemia		Approved	[44]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[276]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[276]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[17]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[339]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[18]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[25]

Drug(s) Affected By Lysophosphatidic acid receptor 3 (LPAR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[16]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[90]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[380]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[56]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[33]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[381]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[59]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[25]

Drug(s) Affected By ATP-binding cassette sub-family F member 2 (ABCF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[26]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[27]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[12]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[37]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[16]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[79]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[19]

Drug(s) Affected By SERTA domain-containing protein 1 (SERTAD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[147]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[49]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[49]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[11]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[49]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[43]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[49]

Drug(s) Affected By Lymphoid enhancer-binding factor 1 (LEF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[382]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[383]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[384]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[385]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Adenosine	DMM2NSK	Paroxysmal supraventricular tachycardia	BC81.Z	Approved	[386]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[241]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[80]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[387]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[56]

Drug(s) Affected By Protein O-mannosyl-transferase 2 (POMT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[379]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[320]

Drug(s) Affected By Malignant T-cell-amplified sequence 1 (MCTS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[82]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[27]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[129]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[120]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[37]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[14]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[80]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[378]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[388]

Drug(s) Affected By Frizzled-4 (FZD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[179]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[389]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[181]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[14]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[45]

Drug(s) Affected By ATP-dependent RNA helicase DDX19B (DDX19B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[163]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[16]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[25]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[168]

Drug(s) Affected By Serine/arginine repetitive matrix protein 2 (SRRM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[82]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[249]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[390]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[11]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[295]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[37]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[391]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[176]

Drug(s) Affected By Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[303]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[37]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[14]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[87]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[392]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[381]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[18]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[393]

Drug(s) Affected By DNA polymerase eta (POLH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[243]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[390]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[70]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[43]
Lomustine	DMMWSUL	Brain cancer	2A00	Approved	[394]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[394]

Drug(s) Affected By Peroxisomal membrane protein PEX16 (PEX16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[76]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[20]

Drug(s) Affected By Adhesion G-protein coupled receptor G1 (ADGRG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[88]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[59]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[105]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[11]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[395]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[396]

Drug(s) Affected By Dehydrogenase/reductase SDR family member 11 (DHRS11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[397]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[397]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[129]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Flufenamic Acid	DMC8VNH	Dysmenorrhea	GA34.3	Approved	[397]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[43]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[61]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[30]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Aldose reductase (AKR1B1)	TTFBNVI	ALDR_HUMAN	Inhibitor	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 (PLCB2)	OTPAHDGO	PLCB2_HUMAN	Gene/Protein Processing	[2]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 (PLCE1)	OTJISZOX	PLCE1_HUMAN	Gene/Protein Processing	[2]
2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2 (OGFOD2)	OTTXP61X	OGFD2_HUMAN	Gene/Protein Processing	[2]
Actin nucleation-promoting factor WAS	OTD03E8M	WASP_HUMAN	Gene/Protein Processing	[2]
Acyl-CoA-binding domain-containing protein 6 (ACBD6)	OTF3XXNI	ACBD6_HUMAN	Gene/Protein Processing	[2]
Acyl-CoA-binding domain-containing protein 7 (ACBD7)	OTTY4K6K	ACBD7_HUMAN	Gene/Protein Processing	[2]
Adhesion G-protein coupled receptor F1 (ADGRF1)	OTRAOBYH	AGRF1_HUMAN	Gene/Protein Processing	[2]
Adhesion G-protein coupled receptor G1 (ADGRG1)	OTQBB8NT	AGRG1_HUMAN	Gene/Protein Processing	[2]
Adhesion G-protein coupled receptor G6 (ADGRG6)	OTY2UBXO	AGRG6_HUMAN	Gene/Protein Processing	[2]
Adhesion G-protein coupled receptor G7 (ADGRG7)	OT4IPNZC	AGRG7_HUMAN	Gene/Protein Processing	[2]

References

• [1] Erigeroflavanone, a flavanone derivative from the flowers of Erigeron annuus with protein glycation and aldose reductase inhibitory activity. J Nat Prod. 2008 Apr;71(4):713-5.
• [2] Molecular mechanisms of quercitrin-induced apoptosis in non-small cell lung cancer. Arch Med Res. 2014 Aug;45(6):445-54.
• [3] Long-term effect of epalrestat, an aldose reductase inhibitor, on the development of incipient diabetic nephropathy in Type 2 diabetic patients. J Diabetes Complications. 2001 Sep-Oct;15(5):241-4.
• [4] Inhibition of human lens aldose reductase by flavonoids, sulindac and indomethacin. Biochem Pharmacol. 1983 Jul 1;32(13):1995-8.
• [5] Clinical efficacy of fidarestat, a novel aldose reductase inhibitor, for diabetic peripheral neuropathy: a 52-week multicenter placebo-controlled double-blind parallel group study. Diabetes Care. 2001 Oct;24(10):1776-82.
• [6] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2768).
• [7] Effect of Polygonum hydropiper sulfated flavonoids on lens aldose reductase and related enzymes. J Nat Prod. 1996 Apr;59(4):443-5.
• [8] ClinicalTrials.gov (NCT02332005) 12-Month Efficacy and Safety of Diepalrestat in Adults With Diabetic Peripheral Neuropathy, a DB, Placebo-Controlled Study (DE-DPN). U.S. National Institutes of Health.
• [9] Discovery of 3-[(4,5,7-trifluorobenzothiazol-2-yl)methyl]indole-N-acetic acid (lidorestat) and congeners as highly potent and selective inhibitors ... J Med Chem. 2005 May 5;48(9):3141-52.
• [10] A multicenter, double-blind, safety study of QR-333 for the treatment of symptomatic diabetic peripheral neuropathy. A preliminary report. J Diabetes Complications. 2005 Sep-Oct;19(5):247-53.
• [11] Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
• [12] Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay. Toxicol Sci. 2015 Aug;146(2):311-20. doi: 10.1093/toxsci/kfv094. Epub 2015 May 15.
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