Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMB8CNL)

Drug Name
Lindane Drug Info
Synonyms
Aalindan; Aficide; Agrocide; Agronexit; Ameisenatod; Ameisentod; Aparasin; Aphtiria; Aphtitria; Aplidal; Arbitex; BBH; Benhexachlor; Benhexol; Benzanex; Benzex; Bexol; Celanex; Chloresene; Codechine; Devoran; Dolmix; Entomoxan; Esoderm; Exagama; Forlin; Gallogama; Gamacarbatox; Gamacid; Gamacide; Gamaphex; Gamene; Gamiso; Gammahexa; Gammahexane; Gammalin; Gammasan; Gammaterr; Gammex; Gammexane; Gammopaz; Gamtox; Geobilan; Gexane; Gyben; HCH; Hcch; Heclotox; Hecoltox; Hexa; Hexablanc; Hexachlor; Hexachloran; Hexachlorane; Hexamul; Hexapoudre; Hexatox; Hexaverm; Hexcidum; Hexicide; Hexit; Hexyclan; Hilbeech; Hortex; Inexit; Isatox; Isotox; Jacutin; Kokotine; Kwell; Lasochron; Lendine; Lentox; Lidenal; Lindafor; Lindagam; Lindagrain; Lindagranox; Lindalo; Lindamul; Lindan; Lindano; Lindanum; Lindapoudre; Lindaterra; Lindatox; Lindex; Lindosep; Lintox; Linvur; Lorexane; Mszycol; Nexit; Nicochloran; Novigam; Novigan; Omnitox; Ovadziak; Owadziak; PLK; Pedraczak; Pflanzol; Quellada; Scabene; Silvanol; Streunex; Submar; Viton; Agrocide III; Agrocide WP; Am eisenatod; Arcotal S; BHCor HCH; Borer Spray; DOL GRANULE; Eso derm; Gamma BHC; HCH [BSI]; HCH [ISO]; Hilbeec h; Isot ox; Lacco HI lin; Lindam ul; Mglawik L; New kotol; Nexen fb; PMS Lindane; Sang gamma; Agrocide 2; Agrocide6G; Agrocide 7; Bentox 10; Detox 25; Gamacide 20; Gammalin 20; Geolin G 3; Hungaria L7; Latka 666; Milbol 49; PS71_SUPELCO; TAP 85; Agrisol G-20; Alpha-BHC; Alpha-HCH; Ben-Hex; Beta-BHC; Beta-HCH; Beta-Lindane; Beta-isomer; D-BHC; Delta-BHC; Delta-HCH; ENT 7,796; ENT 8,601; ENT 9,232; ENT 9,233; ENT 9,234; Epsilon-HCH; Forst-nexen; Gamma-BHC; Gamma-HCH; Gamma-col; HCH (alpha); HCH (beta); KWELL (TN); Kwell-R; Nexen-fb; Nexi t-stark; Nexit-stark; Nexol-E; Sang-gamma; T-HCH; TRI-6; Trives-T
Indication
Disease Entry ICD 11 Status REF
Infestations of lice and scabies 1G00.Z Approved [1]
Pediculus capitis infestation 1G00.0 Approved [2]
Pthirus pubis infestation Approved [2]
Therapeutic Class
Antiscabies Agent
Cross-matching ID
PubChem CID
727
ChEBI ID
CHEBI:24536
TTD Drug ID
DMB8CNL
ACDINA Drug ID
D01211

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Preclinical Drug(s)
Discontinued Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Glutamate receptor AMPA (GRIA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Halothane DM80OZ5 Anaesthesia 9A78.6 Approved [10]
E-2007 DMJDYNQ Diabetic neuropathy 8C0Z Approved [11]
Zopiclone DMPI6Z0 Insomnia 7A00-7A0Z Approved [12]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [13]
Enflurane DM0YJSB Anaesthesia 9A78.6 Approved [14]
Isoflurane DMY6T31 Anaesthesia 9A78.6 Approved [15]
Bromazepam DMY9TCW Anxiety disorder 6B00-6B0Z Approved [16]
Artemisinin SP DMFETDK Malaria 1F40-1F45 Approved [17]
Dihydroergotoxine DM5D6WZ Alzheimer disease 8A20 Approved [18]
Barbiturate DMJIA6T Anaesthesia 9A78.6 Approved [19]
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Drug(s) Affected By Fatty acid synthase (FASN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [20]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [21]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [22]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [23]
Quercetin DM3NC4M Obesity 5B81 Approved [24]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [25]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [26]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [27]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [28]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [29]
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Drug(s) Affected By Cytochrome P450 3A7 (CYP3A7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [27]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [31]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [32]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [33]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [34]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [35]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [36]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [37]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [25]
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Drug(s) Affected By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eplerenone DMF0NQR Heart failure BD10-BD13 Approved [38]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [39]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [40]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [41]
Proguanil DMBL79I Malaria 1F40-1F45 Approved [42]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [42]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [43]
Nelfinavir mesylate DMFX6G8 N. A. N. A. Approved [44]
Capsaicin DMGMF6V Back pain ME84.Z Approved [45]
Axitinib DMGVH6N Renal cell carcinoma 2C90 Approved [46]
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Drug(s) Affected By Cholesterol side-chain cleavage enzyme, mitochondrial (CYP11A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [47]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [48]
Testosterone DM7HUNW Hot flushes GA30 Approved [49]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [51]
Ethanol DMDRQZU Chronic pain MG30 Approved [52]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [53]
Hydroxyflutamide DMGIZF5 Prostate cancer 2C82.0 Approved [54]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [55]
Arsenic DMTL2Y1 N. A. N. A. Approved [56]
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Drug(s) Affected By Aromatase (CYP19A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Letrozole DMH07Y3 Estrogen-receptor positive breast cancer Approved [57]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [58]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [59]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [60]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [59]
Methotrexate DM2TEOL Anterior urethra cancer Approved [61]
FADROZOLE DM3C5GZ Breast cancer 2C60-2C65 Approved [62]
Bifonazole DM3KN7V Fungal infection 1F29-1F2F Approved [63]
Quercetin DM3NC4M Obesity 5B81 Approved [64]
Fluoxetine DM3PD2C Bipolar depression Approved [59]
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Drug(s) Affected By 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (HSD3B2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [65]
Topiramate DM82Z30 Alcohol dependence 6C40.2 Approved [66]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [66]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [51]
Metyrapone DMI7FVQ Cushing disease 5A70 Approved [67]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [65]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [68]
Pioglitazone DMKJ485 Amyotrophic lateral sclerosis 8B60.0 Approved [69]
Levetiracetam DMTGDN8 Epilepsy 8A60-8A68 Approved [51]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [70]
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Drug(s) Affected By Steroidogenic acute regulatory protein, mitochondrial (STAR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Etretinate DM2CZFA Keratosis ED56 Approved [71]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [72]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [73]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [74]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [75]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [51]
Ethanol DMDRQZU Chronic pain MG30 Approved [76]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [77]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [78]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [79]
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Drug(s) Affected By Sulfotransferase 2A1 (SULT2A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [47]
Methotrexate DM2TEOL Anterior urethra cancer Approved [80]
Quercetin DM3NC4M Obesity 5B81 Approved [81]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [27]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [27]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [82]
Leflunomide DMR8ONJ Arthritis FA20 Approved [83]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [84]
Ethanol DMDRQZU Chronic pain MG30 Approved [85]
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Drug(s) Affected By Catalase (CAT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [86]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [87]
Haloperidol DM96SE0 Delirium Approved [88]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [89]
Selenium DM25CGV N. A. N. A. Approved [90]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [91]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [92]
Methotrexate DM2TEOL Anterior urethra cancer Approved [61]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [93]
Quercetin DM3NC4M Obesity 5B81 Approved [81]
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Drug(s) Affected By Cytochrome P450 2E1 (CYP2E1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fomepizole DM6VOWQ Athylene glycol or methanol poisoning NE61 Approved [94]
Ademetionine DMYQDBO Hepatic fibrosis DB93.0 Approved [95]
Theophylline DMRJFN9 Bronchitis CA20 Approved [88]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [96]
Ethanol DMDRQZU Chronic pain MG30 Approved [97]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [98]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Didanosine DMI2QPE Human immunodeficiency virus infection 1C62 Approved [88]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [101]
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Drug(s) Affected By Cytochrome P450 2D6 (CYP2D6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [102]
Paliperidone DM7NPJS Psychotic disorder 6A20-6A25 Approved [103]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [104]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [105]
Oxatomide DM1F42Z Hay fever CA08.00 Approved [106]
Cinacalcet DMCX0K3 Hyperparathyroidism 5A51 Approved [107]
Capsaicin DMGMF6V Back pain ME84.Z Approved [108]
Pentamidine DMHZJCG African trypanosomiasis 1F51 Approved [42]
Quinidine DMLPICK N. A. N. A. Approved [109]
Buprenorphine DMPRI8G Opioid dependence 6C43.2Z Approved [110]
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Drug(s) Affected By Cytochrome P450 2B6 (CYP2B6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [111]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [112]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [113]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [114]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [115]
Clopidogrel DMOL54H Acute coronary syndrome BA41 Approved [116]
Artemisinin DMOY7W3 Malaria 1F40-1F45 Approved [117]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [118]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [119]
Permethrin DMZ0Q1G Pediculus capitis infestation 1G00.0 Approved [120]
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Drug(s) Affected By Steroid hormone receptor ERR1 (ESRRA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [121]
Methotrexate DM2TEOL Anterior urethra cancer Approved [61]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [122]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [74]
Bortezomib DMNO38U Leukemia Approved [123]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [124]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [125]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [125]
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [126]
Isoflavone DM7U58J N. A. N. A. Phase 4 [127]
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Drug(s) Affected By Nitric oxide synthase, inducible (NOS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [128]
Indomethacin DMSC4A7 Bursitis Approved [129]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [130]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [131]
Methotrexate DM2TEOL Anterior urethra cancer Approved [132]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [133]
Quercetin DM3NC4M Obesity 5B81 Approved [134]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [135]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [136]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [137]
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Drug(s) Affected By Small ribosomal subunit protein mS29 (DAP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [72]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [138]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [139]
Menthol DMG2KW7 Back pain ME84.Z Approved [140]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [141]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [142]
Bortezomib DMNO38U Leukemia Approved [143]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [144]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [145]
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Drug(s) Affected By Transcription factor A, mitochondrial (TFAM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [146]
Quercetin DM3NC4M Obesity 5B81 Approved [147]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [122]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [72]
Testosterone DM7HUNW Hot flushes GA30 Approved [148]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [149]
Chloramphenicol DMFXEWT Bacterial infection 1A00-1C4Z Approved [150]
Zalcitabine DMH7MUV Human immunodeficiency virus infection 1C62 Approved [151]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [152]
Pioglitazone DMKJ485 Amyotrophic lateral sclerosis 8B60.0 Approved [122]
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Drug(s) Affected By Nuclear respiratory factor 1 (NRF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [146]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [153]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [154]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [155]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [156]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [157]
Arsenic DMTL2Y1 N. A. N. A. Approved [158]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [98]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [159]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [160]
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Drug(s) Affected By Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PPRC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [161]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [162]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [163]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [161]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [164]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [165]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [166]
Methotrexate DM2TEOL Anterior urethra cancer Approved [167]
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Drug(s) Affected By Dimethyladenosine transferase 2, mitochondrial (TFB2M)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [161]
Selenium DM25CGV N. A. N. A. Approved [20]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [162]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [168]
Leflunomide DMR8ONJ Arthritis FA20 Approved [83]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [149]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [139]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [157]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [169]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [128]
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Drug(s) Affected By Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [81]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [122]
Fructose DM43AN2 Vomiting MD90 Approved [170]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [171]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [153]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [73]
Ketotifen DM74XKS Allergic conjunctivitis 9A60.02 Approved [172]
Riboflavin DM8YMWE Acne vulgaris ED80 Approved [173]
Leflunomide DMR8ONJ Arthritis FA20 Approved [83]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [173]
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Drug(s) Affected By N-arachidonyl glycine receptor (GPR18)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [72]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [4]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [174]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [175]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [4]
3R14S-OCHRATOXIN A DM2KEW6 Discovery agent N.A. Investigative [4]
Milchsaure DM462BT Pruritus EC90 Investigative [176]
Rapamycin Immunosuppressant Drug DM678IB Discovery agent N.A. Investigative [4]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [177]
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Drug(s) Affected By Glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [178]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [4]
Panobinostat DM58WKG Chronic graft versus host disease Approved [179]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [174]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [180]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [178]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [181]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Racecadotril DMFOTZ7 Diarrhea ME05.1 Approved [182]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [123]
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Drug(s) Affected By Serine/threonine-protein kinase Sgk1 (SGK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [183]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [184]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [185]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [186]
Quercetin DM3NC4M Obesity 5B81 Approved [81]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [162]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [4]
Estrone DM5T6US Acne vulgaris ED80 Approved [183]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [187]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [168]
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Drug(s) Affected By Kinesin-like protein KIF21B (KIF21B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [162]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [4]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [188]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [75]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [189]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [163]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [98]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [165]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [128]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [190]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Signal transducing adapter molecule 2 (STAM2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [4]
Testosterone DM7HUNW Hot flushes GA30 Approved [148]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [191]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [192]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [157]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [164]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [128]
Urethane DM7NSI0 N. A. N. A. Phase 4 [193]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [194]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Phospholipid-transporting ATPase ABCA1 (ABCA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [195]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [196]
Quercetin DM3NC4M Obesity 5B81 Approved [81]
Fluoxetine DM3PD2C Bipolar depression Approved [197]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [25]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [198]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [199]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [200]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [201]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [202]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Amino acid transporter heavy chain SLC3A2 (SLC3A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [20]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [203]
Quercetin DM3NC4M Obesity 5B81 Approved [81]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [204]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [205]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [4]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [206]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [4]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [168]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [207]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Asparagine synthetase (ASNS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [178]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [208]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [209]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [208]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [203]
Methotrexate DM2TEOL Anterior urethra cancer Approved [210]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [211]
Fluoxetine DM3PD2C Bipolar depression Approved [208]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [204]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [72]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial (MTHFD2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [203]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [162]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [4]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [4]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [168]
Leflunomide DMR8ONJ Arthritis FA20 Approved [83]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [212]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [139]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [142]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CCAAT/enhancer-binding protein beta (CEBPB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [213]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [161]
Methotrexate DM2TEOL Anterior urethra cancer Approved [80]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [214]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [215]
Quercetin DM3NC4M Obesity 5B81 Approved [216]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [204]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [217]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [4]
Panobinostat DM58WKG Chronic graft versus host disease Approved [179]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein EVI2A (EVI2A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluoxetine DM3PD2C Bipolar depression Approved [4]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [4]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [4]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [218]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [142]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [219]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [220]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [221]
THAPSIGARGIN DMDMQIE N. A. N. A. Preclinical [222]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Trans-acting T-cell-specific transcription factor GATA-3 (GATA3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [161]
Methotrexate DM2TEOL Anterior urethra cancer Approved [61]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [223]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [224]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [225]
Panobinostat DM58WKG Chronic graft versus host disease Approved [179]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [226]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [218]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [227]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Adenylate kinase 4, mitochondrial (AK4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [24]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [228]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [207]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [207]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [75]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [207]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [139]
Folic Acid DMEMBJC Colorectal carcinoma Approved [229]
Adefovir Dipivoxil DMMAWY1 Hepatitis B virus infection 1E51.0 Approved [207]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA-binding protein inhibitor ID-1 (ID1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [230]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [231]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [232]
Selenium DM25CGV N. A. N. A. Approved [20]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [233]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [234]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [235]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [168]
Leflunomide DMR8ONJ Arthritis FA20 Approved [83]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By B-cell lymphoma 6 protein (BCL6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [161]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [72]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [4]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [4]
Leflunomide DMR8ONJ Arthritis FA20 Approved [83]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [68]
Bortezomib DMNO38U Leukemia Approved [123]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [157]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [236]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Regulator of G-protein signaling 2 (RGS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [161]
Methotrexate DM2TEOL Anterior urethra cancer Approved [61]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [237]
Quercetin DM3NC4M Obesity 5B81 Approved [81]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [162]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [238]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [168]
Testosterone DM7HUNW Hot flushes GA30 Approved [148]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [239]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [155]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ATP-binding cassette sub-family G member 1 (ABCG1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [196]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [25]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [228]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [113]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [168]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [207]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [207]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [207]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [212]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Radiation-inducible immediate-early gene IEX-1 (IER3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [213]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [232]
Selenium DM25CGV N. A. N. A. Approved [240]
Quercetin DM3NC4M Obesity 5B81 Approved [81]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [204]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [217]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [4]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [241]
Panobinostat DM58WKG Chronic graft versus host disease Approved [179]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [235]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CX3C chemokine receptor 1 (CX3CR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [242]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [72]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [243]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [244]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [128]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [34]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [245]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [246]
GW-501516 DMPL2KM Type-1 diabetes 5A10 Discontinued in Phase 4 [243]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cysteine--tRNA ligase, cytoplasmic (CARS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [247]
Methotrexate DM2TEOL Anterior urethra cancer Approved [80]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [72]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [4]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [238]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [207]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [207]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [189]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [207]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sestrin-2 (SESN2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [178]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [86]
Methotrexate DM2TEOL Anterior urethra cancer Approved [248]
Quercetin DM3NC4M Obesity 5B81 Approved [81]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [204]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [4]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [206]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [4]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [249]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [178]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [250]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [251]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [161]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [252]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [252]
Quercetin DM3NC4M Obesity 5B81 Approved [24]
Fluoxetine DM3PD2C Bipolar depression Approved [252]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [25]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [253]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [217]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Early activation antigen CD69 (CD69)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [217]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [4]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [254]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [4]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [156]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [255]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [78]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [256]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [257]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [258]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transmembrane protein 267 (TMEM267)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [72]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [4]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [4]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [259]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [256]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [260]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [164]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [245]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [4]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Proline-rich nuclear receptor coactivator 1 (PNRC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [161]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [233]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [73]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [75]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [259]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [68]
Bexarotene DMOBIKY Cutaneous T-cell lymphoma 2B01 Approved [261]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [157]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [260]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [163]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Baculoviral IAP repeat-containing protein 3 (BIRC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [262]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [263]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [251]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [264]
Methotrexate DM2TEOL Anterior urethra cancer Approved [132]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [25]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [162]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [4]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [265]
Trovafloxacin DM6AN32 Acute gonococcal cervicitis Approved [266]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Inactive phospholipase C-like protein 1 (PLCL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [251]
Fluoxetine DM3PD2C Bipolar depression Approved [4]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [4]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [259]
Folic Acid DMEMBJC Colorectal carcinoma Approved [267]
Prednisolone DMQ8FR2 Acute adrenal insufficiency Approved [4]
Urethane DM7NSI0 N. A. N. A. Phase 4 [193]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [30]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [268]
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Drug(s) Affected By Cyclin-G2 (CCNG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [183]
Quercetin DM3NC4M Obesity 5B81 Approved [81]
Fluoxetine DM3PD2C Bipolar depression Approved [4]
Panobinostat DM58WKG Chronic graft versus host disease Approved [179]
Estrone DM5T6US Acne vulgaris ED80 Approved [183]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [73]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [191]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [207]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [207]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [75]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Programmed cell death protein 4 (PDCD4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [269]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [161]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [270]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [269]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [206]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [73]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [271]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [235]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [269]
Testosterone DM7HUNW Hot flushes GA30 Approved [148]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transmembrane protein 177 (TMEM177)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [72]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [4]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [156]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [255]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [142]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [272]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [157]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [161]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [273]
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Drug(s) Affected By Kelch-like protein 24 (KLHL24)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [161]
Fluoxetine DM3PD2C Bipolar depression Approved [4]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [162]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [73]
Testosterone DM7HUNW Hot flushes GA30 Approved [148]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [155]
Testosterone enanthate DMB6871 N. A. N. A. Approved [274]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [259]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [255]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [68]
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Drug(s) Affected By Uncharacterized protein C15orf39 (C15ORF39)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [255]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [157]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [163]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [161]
Arsenic DMTL2Y1 N. A. N. A. Approved [56]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [164]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [165]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [128]
Urethane DM7NSI0 N. A. N. A. Phase 4 [193]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear receptor coactivator 7 (NCOA7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [161]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [162]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [4]
Panobinostat DM58WKG Chronic graft versus host disease Approved [179]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [275]
Leflunomide DMR8ONJ Arthritis FA20 Approved [83]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [155]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [255]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [139]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Prostamide/prostaglandin F synthase (PRXL2B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [213]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [4]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [168]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [256]
Pioglitazone DMKJ485 Amyotrophic lateral sclerosis 8B60.0 Approved [276]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [128]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [277]
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Drug(s) Affected By Alanine aminotransferase 2 (GPT2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [278]
Quercetin DM3NC4M Obesity 5B81 Approved [81]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [72]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [4]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [206]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [4]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [218]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Motexafin gadolinium DMEJKRF Brain cancer 2A00 Approved [206]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nanos homolog 1 (NANOS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [228]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [4]
Panobinostat DM58WKG Chronic graft versus host disease Approved [179]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [168]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [75]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [123]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [279]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [280]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [281]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Proto-oncogene FRAT1 (FRAT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [20]
Quercetin DM3NC4M Obesity 5B81 Approved [81]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [282]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [98]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [30]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [149]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [283]
Urethane DM7NSI0 N. A. N. A. Phase 4 [193]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By F-box only protein 32 (FBXO32)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [178]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [4]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [178]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [191]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [75]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [156]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [284]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [142]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [280]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [157]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Insulin gene enhancer protein ISL-2 (ISL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [4]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [4]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [75]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [156]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [157]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [163]
Urethane DM7NSI0 N. A. N. A. Phase 4 [193]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [4]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [277]
3R14S-OCHRATOXIN A DM2KEW6 Discovery agent N.A. Investigative [4]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transmembrane and coiled-coil domain-containing protein 6 (TMCO6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [4]
Testosterone DM7HUNW Hot flushes GA30 Approved [148]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [75]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [259]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [281]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [169]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [128]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [149]
Urethane DM7NSI0 N. A. N. A. Phase 4 [193]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [221]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By E3 ubiquitin-protein ligase pellino homolog 1 (PELI1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [72]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [4]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [4]
Leflunomide DMR8ONJ Arthritis FA20 Approved [83]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [75]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [256]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [157]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [285]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [163]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Centriolar and ciliogenesis-associated protein HYLS1 (HYLS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [81]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [72]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [4]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [249]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [75]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [255]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [142]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [157]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [169]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Germ cell nuclear acidic protein (GCNA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [81]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [255]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [157]
Urethane DM7NSI0 N. A. N. A. Phase 4 [193]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [286]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [30]
Torcetrapib DMDHYM7 Hyperlipidaemia 5C80 Discontinued in Phase 2 [287]
THAPSIGARGIN DMDMQIE N. A. N. A. Preclinical [288]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tribbles homolog 3 (TRIB3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [178]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [253]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [289]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [4]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [206]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [290]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [4]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [235]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [291]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [168]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transmembrane 6 superfamily member 1 (TM6SF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [4]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [4]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [292]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Racecadotril DMFOTZ7 Diarrhea ME05.1 Approved [182]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [284]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [281]
Arsenic DMTL2Y1 N. A. N. A. Approved [56]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [293]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [294]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein FAM107B (FAM107B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [247]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [289]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [4]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [4]
Testosterone DM7HUNW Hot flushes GA30 Approved [148]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [191]
Leflunomide DMR8ONJ Arthritis FA20 Approved [83]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [255]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [142]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [157]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By 2-aminomuconic semialdehyde dehydrogenase (ALDH8A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [182]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Racecadotril DMFOTZ7 Diarrhea ME05.1 Approved [182]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [253]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [295]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [256]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [296]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [297]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [164]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Semaphorin-3G (SEMA3G)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [81]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [4]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [168]
Leflunomide DMR8ONJ Arthritis FA20 Approved [83]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [75]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [259]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [279]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [165]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [149]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [298]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cysteine-rich motor neuron 1 protein (CRIM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [228]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [299]
Testosterone DM7HUNW Hot flushes GA30 Approved [148]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [155]
Testosterone enanthate DMB6871 N. A. N. A. Approved [274]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [139]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [142]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [300]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [157]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DnaJ homolog subfamily B member 4 (DNAJB4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [178]
Selenium DM25CGV N. A. N. A. Approved [20]
Quercetin DM3NC4M Obesity 5B81 Approved [81]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [135]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [4]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [206]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [188]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [301]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [291]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [178]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By SLAM family member 5 (CD84)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [72]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [4]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [4]
Epanova DMHEAGL Hypertriglyceridemia 5C80.1 Approved [302]
Pioglitazone DMKJ485 Amyotrophic lateral sclerosis 8B60.0 Approved [276]
Prednisolone DMQ8FR2 Acute adrenal insufficiency Approved [4]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [297]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [303]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [221]
Rapamycin Immunosuppressant Drug DM678IB Discovery agent N.A. Investigative [4]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cystine/glutamate transporter (SLC7A11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [304]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [305]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [278]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [305]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [305]
Methotrexate DM2TEOL Anterior urethra cancer Approved [210]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [306]
Quercetin DM3NC4M Obesity 5B81 Approved [81]
Fluoxetine DM3PD2C Bipolar depression Approved [4]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [305]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear factor erythroid 2-related factor 3 (NFE2L3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [161]
Quercetin DM3NC4M Obesity 5B81 Approved [81]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [228]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [4]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [123]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [142]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [296]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [157]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dual specificity protein phosphatase 10 (DUSP10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [307]
Methotrexate DM2TEOL Anterior urethra cancer Approved [308]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [27]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [4]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [27]
Panobinostat DM58WKG Chronic graft versus host disease Approved [179]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [4]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [291]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [191]
Leflunomide DMR8ONJ Arthritis FA20 Approved [83]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Solute carrier family 22 member 1 (SLC22A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Phenoxybenzamine DM8KSQH Malignant essential hypertension BA00 Approved [309]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [310]
Trospium chloride DM32XZT Discovery agent N.A. Approved [311]
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [312]
Lamivudine DMI347A Chronic HBV infection 1E51.0Z Approved [313]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [314]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [253]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [72]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [315]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [314]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [316]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [317]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [318]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [319]
Cepharanthine DM9Y5JB N. A. N. A. Approved [320]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [321]
Clozapine DMFC71L Schizophrenia 6A20 Approved [322]
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [323]
Trifluoperazine DMKBYWI Anxiety Approved [324]
Olanzapine DMPFN6Y Bipolar depression Approved [322]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Hepatic sodium/bile acid cotransporter (SLC10A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Clavulanate DM2FGRT Bacteremia 1A73 Approved [325]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [326]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [253]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [327]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [82]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [328]
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [329]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [253]
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Drug(s) Affected By Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [330]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [330]
Gefitinib DM15F0X Colon adenocarcinoma Approved [331]
Sunitinib DMCBJSR Acute undifferentiated leukemia Approved [88]
Rosuvastatin DMMIQ7G Arteriosclerosis BD40 Approved [332]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [333]
Methotrexate DM2TEOL Anterior urethra cancer Approved [334]
Quercetin DM3NC4M Obesity 5B81 Approved [335]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [205]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [336]
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Drug(s) Affected By Glutathione reductase, mitochondrial (GSR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [337]
Ketoprofen DMRKXPT Bursitis Approved [88]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [89]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [338]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [325]
Quercetin DM3NC4M Obesity 5B81 Approved [339]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [25]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [340]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [206]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [341]
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Drug(s) Affected By Leukemia inhibitory factor (LIF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [213]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [342]
Methotrexate DM2TEOL Anterior urethra cancer Approved [132]
Quercetin DM3NC4M Obesity 5B81 Approved [81]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [204]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [343]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [344]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [168]
Leflunomide DMR8ONJ Arthritis FA20 Approved [83]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [155]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glutamate--cysteine ligase catalytic subunit (GCLC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [304]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [345]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [346]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [325]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [347]
Quercetin DM3NC4M Obesity 5B81 Approved [348]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [204]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [72]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [349]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [350]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glutamate--cysteine ligase regulatory subunit (GCLM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [304]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [278]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [325]
Quercetin DM3NC4M Obesity 5B81 Approved [351]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [72]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [241]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [206]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [290]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [299]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [301]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sequestosome-1 (SQSTM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [352]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [353]
Gefitinib DM15F0X Colon adenocarcinoma Approved [354]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [47]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [355]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [203]
Methotrexate DM2TEOL Anterior urethra cancer Approved [132]
Quercetin DM3NC4M Obesity 5B81 Approved [81]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [204]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [356]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glycerol-3-phosphate acyltransferase 3 (GPAT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [357]
Quercetin DM3NC4M Obesity 5B81 Approved [81]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [228]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [235]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [207]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [207]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [207]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [189]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [207]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sulfiredoxin-1 (SRXN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [304]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [161]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [204]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [162]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [358]
Ethacrynic acid DM60QMR Edema MG29 Approved [359]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [4]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [207]
Leflunomide DMR8ONJ Arthritis FA20 Approved [83]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [207]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Neutrophil cytosol factor 1 (NCF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [360]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [217]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [361]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Ethanol DMDRQZU Chronic pain MG30 Approved [362]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [163]
Arsenic DMTL2Y1 N. A. N. A. Approved [363]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [364]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [365]
Tamibarotene DM3G74J T-cell leukaemia 2A90 Phase 3 [217]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nitric oxide synthase 3 (NOS3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [366]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [367]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [88]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [368]
Methotrexate DM2TEOL Anterior urethra cancer Approved [80]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [369]
Quercetin DM3NC4M Obesity 5B81 Approved [370]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [371]
Fructose DM43AN2 Vomiting MD90 Approved [372]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 7A1 (CYP7A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcipotriol DM03CP7 Psoriasis EA90 Approved [374]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [325]
Methotrexate DM2TEOL Anterior urethra cancer Approved [80]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [375]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [326]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [135]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [376]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [82]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [119]
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [375]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sterol 26-hydroxylase, mitochondrial (CYP27A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Clavulanate DM2FGRT Bacteremia 1A73 Approved [325]
Methotrexate DM2TEOL Anterior urethra cancer Approved [195]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [25]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [27]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [377]
Testosterone DM7HUNW Hot flushes GA30 Approved [148]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [218]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [378]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bile acid receptor (NR1H4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [357]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [379]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [329]
Quercetin DM3NC4M Obesity 5B81 Approved [81]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [380]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [82]
Nisoldipine DM7ISKJ Hypertension BA00-BA04 Approved [379]
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [329]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [381]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase (CYP8B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Chenodiol DMQ8JIK Cholelithiasis DC11 Approved [329]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [325]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [329]
Quercetin DM3NC4M Obesity 5B81 Approved [81]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [25]
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [329]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Arsenic DMTL2Y1 N. A. N. A. Approved [56]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [112]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glycine receptor subunit alpha-3 (GLRA3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [382]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [246]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [251]
Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [383]
Vidarabine DM0N85H Hepatosplenic T-cell lymphoma Approved [383]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [384]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [385]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [386]
Etidronic acid DM1XHYJ Bone Paget disease Approved [383]
Tiaprofenic acid DM23D7J Osteoarthritis FA00-FA05 Approved [383]
Bromperidol DM24XYQ Schizophrenia 6A20 Approved [383]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [387]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [388]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Prolactin (PRL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [389]
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [390]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [391]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [392]
Methotrexate DM2TEOL Anterior urethra cancer Approved [61]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [393]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [394]
Aripiprazole DM3NUMH Bipolar I disorder Approved [395]
Fluoxetine DM3PD2C Bipolar depression Approved [396]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [397]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor (TNF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [398]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [399]
Fructose DM43AN2 Vomiting MD90 Approved [88]
Ketoprofen DMRKXPT Bursitis Approved [88]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [400]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [401]
Baclofen DM0QV1J Multiple sclerosis 8A40 Approved [402]
Gefitinib DM15F0X Colon adenocarcinoma Approved [403]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [404]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [405]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interferon gamma (IFNG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [297]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [406]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [407]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [408]
Methotrexate DM2TEOL Anterior urethra cancer Approved [61]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [409]
Quercetin DM3NC4M Obesity 5B81 Approved [410]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [411]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [412]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [413]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Estrogen receptor (ESR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [414]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [415]
Gefitinib DM15F0X Colon adenocarcinoma Approved [416]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [417]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [418]
Liraglutide DM3FXPS Non-insulin dependent diabetes 5A11 Approved [419]
Quercetin DM3NC4M Obesity 5B81 Approved [420]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [421]
Procaine DM4LSNE Anaesthesia 9A78.6 Approved [417]
Estrone DM5T6US Acne vulgaris ED80 Approved [422]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Trefoil factor 1 (TFF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [423]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [161]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [424]
Quercetin DM3NC4M Obesity 5B81 Approved [425]
Estrone DM5T6US Acne vulgaris ED80 Approved [426]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [427]
Reserpine DM6VM38 Hypertension BA00-BA04 Approved [424]
Testosterone DM7HUNW Hot flushes GA30 Approved [428]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [218]
Exemestane DM9HPW3 Hormonally-responsive breast cancer 2C60-2C65 Approved [429]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Receptor tyrosine-protein kinase erbB-2 (ERBB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Trastuzumab DMZQOUX Breast cancer 2C60-2C65 Approved [88]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [430]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [431]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [432]
Gefitinib DM15F0X Colon adenocarcinoma Approved [433]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [232]
Selenium DM25CGV N. A. N. A. Approved [20]
Methotrexate DM2TEOL Anterior urethra cancer Approved [132]
Quercetin DM3NC4M Obesity 5B81 Approved [434]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [228]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-5 (IL5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [406]
Tolnaftate DM28MU7 Dermatophytosis 1F28.2 Approved [435]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [436]
Prednisone DM2HG4X Acute asthma CA23 Approved [437]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [438]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [225]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [439]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [440]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [441]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [442]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor Jun (JUN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [443]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [364]
Fructose DM43AN2 Vomiting MD90 Approved [88]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [444]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [445]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [307]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [446]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [278]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [447]
Methotrexate DM2TEOL Anterior urethra cancer Approved [448]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Thyroxine-binding globulin (SERPINA7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Leuprolide DM5XPIJ Plasma cell myeloma 2A83.1 Approved [88]
Quercetin DM3NC4M Obesity 5B81 Approved [81]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [449]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [296]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [157]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [98]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [30]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [166]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Progesterone receptor (PGR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [450]
Drospirenone DM1A9W3 Acne vulgaris ED80 Approved [451]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [452]
Estrone DM5T6US Acne vulgaris ED80 Approved [453]
Tibolone DM78XFG Anabolic metabolism 5C50-5C8Z Approved [454]
Testosterone DM7HUNW Hot flushes GA30 Approved [455]
Exemestane DM9HPW3 Hormonally-responsive breast cancer 2C60-2C65 Approved [429]
Goserelin DMAT8CG Breast cancer 2C60-2C65 Approved [456]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [457]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Prostate-specific antigen (KLK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [60]
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [458]
Selenium DM25CGV N. A. N. A. Approved [459]
Quercetin DM3NC4M Obesity 5B81 Approved [460]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [461]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [462]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [463]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [464]
Testosterone DM7HUNW Hot flushes GA30 Approved [465]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [50]
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Drug(s) Affected By Heat shock 70 kDa protein 1A (HSPA1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [466]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [178]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [307]
Gefitinib DM15F0X Colon adenocarcinoma Approved [467]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [342]
Selenium DM25CGV N. A. N. A. Approved [20]
Etretinate DM2CZFA Keratosis ED56 Approved [468]
Methotrexate DM2TEOL Anterior urethra cancer Approved [61]
Quercetin DM3NC4M Obesity 5B81 Approved [81]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [135]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Androgen receptor (AR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [469]
Nilutamide DMFN07X Prostate cancer 2C82.0 Approved [469]
Hydroxyflutamide DMGIZF5 Prostate cancer 2C82.0 Approved [469]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [470]
Bicalutamide DMZMSPF Prostate cancer 2C82.0 Approved [471]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [450]
Drospirenone DM1A9W3 Acne vulgaris ED80 Approved [472]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [379]
Selenium DM25CGV N. A. N. A. Approved [459]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [473]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Retinoic acid receptor alpha (RARA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [474]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [60]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [475]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [207]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [207]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [207]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [207]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [476]
Ethanol DMDRQZU Chronic pain MG30 Approved [477]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [207]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [478]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [479]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [480]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [481]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [88]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [213]
Verapamil DMA7PEW Angina pectoris BA40 Approved [482]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [483]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [401]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [484]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Medium-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [61]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [289]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [241]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [485]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [191]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [139]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [486]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [157]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [163]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [487]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [60]
Gefitinib DM15F0X Colon adenocarcinoma Approved [403]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [405]
Selenium DM25CGV N. A. N. A. Approved [488]
Pentosan Polysulfate DM2HRKE Interstitial cystitis GC00.3 Approved [489]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [490]
Methotrexate DM2TEOL Anterior urethra cancer Approved [491]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [492]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [493]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Histone H2AX (H2AX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [494]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [495]
Selenium DM25CGV N. A. N. A. Approved [20]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [496]
Etretinate DM2CZFA Keratosis ED56 Approved [497]
Methotrexate DM2TEOL Anterior urethra cancer Approved [498]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [306]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [499]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [500]
Quercetin DM3NC4M Obesity 5B81 Approved [501]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Short-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [20]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [157]
Arsenic DMTL2Y1 N. A. N. A. Approved [56]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [98]
Urethane DM7NSI0 N. A. N. A. Phase 4 [193]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [20]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [221]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [277]
CITCO DM0N634 Discovery agent N.A. Investigative [502]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [503]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Gamma-aminobutyric acid receptor subunit beta-1 (GABRB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [228]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [259]
Folic Acid DMEMBJC Colorectal carcinoma Approved [504]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [68]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [505]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [245]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [221]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [251]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Glycine receptor subunit alpha-1 (GLRA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [88]
Quercetin DM3NC4M Obesity 5B81 Approved [506]
Leflunomide DMR8ONJ Arthritis FA20 Approved [83]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [507]
Glycine DMIOZ29 Allergic rhinitis CA08.0 Approved [508]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [506]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [221]
acetaldehyde DMJFKG4 Discovery agent N.A. Investigative [509]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Glycine receptor subunit alpha-2 (GLRA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [221]
[3H]methyltrienolone DMTSGOW Discovery agent N.A. Investigative [510]
Drug(s) Affected By Gamma-aminobutyric acid receptor subunit rho-1 (GABRR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [228]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [511]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [221]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [512]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [511]
Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [513]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [514]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [484]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [415]
Gefitinib DM15F0X Colon adenocarcinoma Approved [515]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [516]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [517]
Selenium DM25CGV N. A. N. A. Approved [20]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [518]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [519]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [520]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [521]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [522]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [401]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [523]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [524]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [525]
Gefitinib DM15F0X Colon adenocarcinoma Approved [526]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [527]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [528]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Gamma-aminobutyric acid receptor subunit beta-3 (GABRB3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [228]
Panobinostat DM58WKG Chronic graft versus host disease Approved [179]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [511]
Testosterone DM7HUNW Hot flushes GA30 Approved [148]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Flunitrazepam DMGR5Z3 Insomnia 7A00-7A0Z Approved [529]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [530]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [157]
Flumazenil DMPCG2L Benzodiazepine overdose PC91 Approved [531]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [532]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [533]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [521]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [534]
Paclitaxel DMLB81S Breast carcinoma Approved [535]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [536]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [520]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [88]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [537]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [401]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [523]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Retinoic acid receptor RXR-beta (RXRB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [538]
Leflunomide DMR8ONJ Arthritis FA20 Approved [83]
Testosterone enanthate DMB6871 N. A. N. A. Approved [274]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [259]
Capsaicin DMGMF6V Back pain ME84.Z Approved [539]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [540]
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [541]
Bexarotene DMOBIKY Cutaneous T-cell lymphoma 2B01 Approved [540]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [542]
Arsenic DMTL2Y1 N. A. N. A. Approved [56]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Aryl hydrocarbon receptor (AHR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [60]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [543]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [544]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [545]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [546]
Quercetin DM3NC4M Obesity 5B81 Approved [547]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [548]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [162]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [549]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [550]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sterol regulatory element-binding protein 1 (SREBF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [204]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [88]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [474]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [551]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [325]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [552]
Quercetin DM3NC4M Obesity 5B81 Approved [81]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [25]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [72]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [202]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Breast cancer type 1 susceptibility protein (BRCA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [213]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [415]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [553]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [554]
Methotrexate DM2TEOL Anterior urethra cancer Approved [132]
Quercetin DM3NC4M Obesity 5B81 Approved [555]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [556]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [204]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [217]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [73]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [557]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [558]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [446]
Gefitinib DM15F0X Colon adenocarcinoma Approved [559]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [516]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [342]
Etretinate DM2CZFA Keratosis ED56 Approved [560]
Prednisone DM2HG4X Acute asthma CA23 Approved [561]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [562]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [186]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [478]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [263]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [213]
Verapamil DMA7PEW Angina pectoris BA40 Approved [482]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [474]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [563]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [516]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [232]
Meloxicam DM2AR7L Arthritis FA20 Approved [564]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [562]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear receptor subfamily 1 group I member 3 (NR1I3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [387]
Quercetin DM3NC4M Obesity 5B81 Approved [565]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [26]
Artemether DM48QOT Malaria 1F40-1F45 Approved [566]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [567]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [82]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [549]
Estrone DM5T6US Acne vulgaris ED80 Approved [568]
Leflunomide DMR8ONJ Arthritis FA20 Approved [569]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Estrogen receptor beta (ESR2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [60]
Gefitinib DM15F0X Colon adenocarcinoma Approved [570]
Quercetin DM3NC4M Obesity 5B81 Approved [571]
Estrone DM5T6US Acne vulgaris ED80 Approved [572]
Tibolone DM78XFG Anabolic metabolism 5C50-5C8Z Approved [573]
Testosterone DM7HUNW Hot flushes GA30 Approved [574]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [575]
Mestranol DMG3F94 Contraception QA21 Approved [576]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [577]
Paclitaxel DMLB81S Breast carcinoma Approved [520]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Parkinson disease protein 7 (PARK7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [578]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [149]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [139]
Menthol DMG2KW7 Back pain ME84.Z Approved [140]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [337]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [145]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [579]
Sodium phenylbutyrate DMXLBCQ Spinal muscular atrophy 8B61 Approved [580]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [581]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [582]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ATP-binding cassette sub-family G member 8 (ABCG8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [81]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [200]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [583]
Leflunomide DMR8ONJ Arthritis FA20 Approved [83]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Chenodiol DMQ8JIK Cholelithiasis DC11 Approved [584]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [98]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [30]
Urethane DM7NSI0 N. A. N. A. Phase 4 [193]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Adiponectin (ADIPOQ)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [585]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [585]
Ramipril DM2R68E Acute heart failure BD10-BD13 Approved [586]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [587]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [585]
Cilazapril DM4V6JA Congestive heart failure BD10 Approved [588]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [589]
Stavudine DM6DEK9 Human immunodeficiency virus infection 1C62 Approved [585]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [590]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [591]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ATP-citrate synthase (ACLY)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [22]
Quercetin DM3NC4M Obesity 5B81 Approved [592]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [253]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [241]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [593]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [139]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [594]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [78]
OPC-34712 DMHG57U Major depressive disorder 6A70.3 Approved [595]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glutathione S-transferase Mu 1 (GSTM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Busulfan DMXYJ9C Chronic myelogenous leukaemia 2A20.0 Approved [596]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [597]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [167]
Ethanol DMDRQZU Chronic pain MG30 Approved [598]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [27]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [27]
Methyldopa DM5I621 Hypertension BA00-BA04 Approved [599]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [73]
Testosterone DM7HUNW Hot flushes GA30 Approved [50]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [50]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Glutamate receptor AMPA (GRIA) TTAN6JD NOUNIPROTAC Antagonist [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
2-aminomuconic semialdehyde dehydrogenase (ALDH8A1) OTINY3MW AL8A1_HUMAN Gene/Protein Processing [4]
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (HSD3B2) OT02MSKN 3BHS2_HUMAN Gene/Protein Processing [5]
7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase (CYP8B1) OTRI4UR1 CP8B1_HUMAN Gene/Protein Processing [6]
Adenylate kinase 4, mitochondrial (AK4) OTA0T02Q KAD4_HUMAN Gene/Protein Processing [4]
Adiponectin (ADIPOQ) OTNX23LE ADIPO_HUMAN Drug Response [7]
Alanine aminotransferase 2 (GPT2) OTS5VF7N ALAT2_HUMAN Gene/Protein Processing [4]
Amino acid transporter heavy chain SLC3A2 (SLC3A2) OTBR33M9 4F2_HUMAN Gene/Protein Processing [4]
Androgen receptor (AR) OTUBKAZZ ANDR_HUMAN Gene/Protein Processing [8]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [9]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [9]

References

1 FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 088190.
2 Lindane FDA Label
3 NMDA-induced seizure intensity is enhanced in COX-2 deficient mice. Neurotoxicology. 2008 Nov;29(6):1114-20.
4 Transcriptome-based functional classifiers for direct immunotoxicity. Arch Toxicol. 2014 Mar;88(3):673-89.
5 Steroidogenic gene expression in H295R cells and the human adrenal gland: adrenotoxic effects of lindane in vitro. J Appl Toxicol. 2006 Nov-Dec;26(6):484-92.
6 Organochloride pesticides modulated gut microbiota and influenced bile acid metabolism in mice. Environ Pollut. 2017 Jul;226:268-276.
7 Interaction between -hexachlorocyclohexane and ADIPOQ genotypes contributes to the risk of type 2 diabetes mellitus in East Chinese adults. Sci Rep. 2016 Nov 24;6:37769. doi: 10.1038/srep37769.
8 -Hexachlorocyclohexane: A Small Molecule with a Big Impact on Human Cellular Biochemistry. Biomedicines. 2020 Nov 16;8(11):505. doi: 10.3390/biomedicines8110505.
9 Low dose induction of micronuclei by lindane. Carcinogenesis. 2004 Apr;25(4):613-22. doi: 10.1093/carcin/bgh048. Epub 2003 Dec 19.
10 Reduced inhibition of cortical glutamate and GABA release by halothane in mice lacking the K+ channel, TREK-1. Br J Pharmacol. 2007 Nov;152(6):939-45.
11 Nat Rev Drug Discov. 2013 Feb;12(2):87-90.
12 Eszopiclone: its use in the treatment of insomnia. Neuropsychiatr Dis Treat. 2007 Aug;3(4):441-453.
13 Effects of sevoflurane on carrageenan- and fentanyl-induced pain hypersensitivity in Sprague-Dawley rats. Can J Anaesth. 2009 Feb;56(2):126-35.
14 Enflurane directly depresses glutamate AMPA and NMDA currents in mouse spinal cord motor neurons independent of actions on GABAA or glycine receptors. Anesthesiology. 2000 Oct;93(4):1075-84.
15 Transmembrane residues define the action of isoflurane at the GABAA receptor alpha-3 subunit. Brain Res. 2005 Jan 25;1032(1-2):30-5.
16 Glutamatergic and GABAergic modulations of ultrasonic vocalizations during maternal separation distress in mouse pups. Psychopharmacology (Berl). 2009 May;204(1):61-71.
17 GABA(A) receptor ligands and their therapeutic potentials. Curr Top Med Chem. 2002 Aug;2(8):817-32.
18 Pharmacologic management of Alzheimer disease, Part II: Antioxidants, antihypertensives, and ergoloid derivatives. Ann Pharmacother. 1999 Feb;33(2):188-97.
19 Anaesthetic drugs: linking molecular actions to clinical effects. Curr Pharm Des. 2006;12(28):3665-79.
20 Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
21 Low-expressional IGF1 mediated methimazole-induced liver developmental toxicity in fetal mice. Toxicology. 2018 Sep 1;408:70-79. doi: 10.1016/j.tox.2018.07.004. Epub 2018 Jul 7.
22 Drug-induced hepatic steatosis in absence of severe mitochondrial dysfunction in HepaRG cells: proof of multiple mechanism-based toxicity. Cell Biol Toxicol. 2021 Apr;37(2):151-175. doi: 10.1007/s10565-020-09537-1. Epub 2020 Jun 14.
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