General Information of Drug (ID: DM62UG5)

Drug Name
Vemurafenib Drug Info
Synonyms PLX4032; RG7204; RO5185426; Zelboraf (TN); Vemurafenib (BRAF inhibitor)
Indication
Disease Entry ICD 11 Status REF
Melanoma 2C30 Approved [1]
Cross-matching ID
PubChem CID
42611257
ChEBI ID
CHEBI:63637
CAS Number
CAS 918504-65-1
TTD Drug ID
DM62UG5
VARIDT Drug ID
DR00711
INTEDE Drug ID
DR1677
ACDINA Drug ID
D00723

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dabrafenib DMX6OE3 Melanoma 2C30 Approved [12]
LGX818 DMNQXV8 Melanoma 2C30 Approved [13]
PLX8394 DMRTD7I Solid tumour/cancer 2A00-2F9Z Phase 2 [14]
CEP-32496 DMAO04B Solid tumour/cancer 2A00-2F9Z Phase 1/2 [15]
BGB-283 DMVYTG7 Solid tumour/cancer 2A00-2F9Z Phase 1/2 [16]
ARQ 736 DMP9ZT1 Solid tumour/cancer 2A00-2F9Z Phase 1 [17]
RO-5212054 DML4C3Q Solid tumour/cancer 2A00-2F9Z Phase 1 [18]
ASN003 DMJCX6D Solid tumour/cancer 2A00-2F9Z Phase 1 [19]
BMS-908662 DM3K8VM Solid tumour/cancer 2A00-2F9Z Phase 1 [20]
ABM-1310 DMS1HR3 Solid tumour/cancer 2A00-2F9Z Phase 1 [21]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [170]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [137]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [171]
Leflunomide DMR8ONJ Arthritis FA20 Approved [172]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [173]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [57]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [174]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [175]
Famotidine DMRL3AB Gastric ulcer DA60 Approved [176]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [177]
⏷ Show the Full List of 20 Drug(s)
Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [22]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [23]
Methotrexate DM2TEOL Anterior urethra cancer Approved [24]
Folic Acid DMEMBJC Colorectal carcinoma Approved [25]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [24]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [24]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [26]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [24]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [27]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [28]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [29]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [30]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [3]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [31]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [3]
Pravastatin DM6A0X7 Adult acute monocytic leukemia Approved [32]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [33]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [34]
Cerivastatin DMXCM7H Hyperlipidaemia 5C80 Approved [35]
PITAVASTATIN CALCIUM DM1UJO0 Dyslipidemia 5C80-5C81 Approved [32]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [36]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [3]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [37]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [38]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [3]
Pravastatin DM6A0X7 Adult acute monocytic leukemia Approved [39]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [33]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [35]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [40]
Cerivastatin DMXCM7H Hyperlipidaemia 5C80 Approved [35]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [41]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [42]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [43]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [44]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [45]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [46]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [47]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [48]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [42]
Verapamil DMA7PEW Angina pectoris BA40 Approved [49]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [50]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [51]
Quercetin DM3NC4M Obesity 5B81 Approved [52]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [53]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [54]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [55]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [56]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [57]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [58]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [59]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [60]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [61]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [62]
Gefitinib DM15F0X Colon adenocarcinoma Approved [63]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [64]
Selenium DM25CGV N. A. N. A. Approved [65]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [66]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [67]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [68]
Methotrexate DM2TEOL Anterior urethra cancer Approved [69]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [70]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [71]
Selenium DM25CGV N. A. N. A. Approved [65]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [72]
Methotrexate DM2TEOL Anterior urethra cancer Approved [73]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [74]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [75]
Quercetin DM3NC4M Obesity 5B81 Approved [76]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [77]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [78]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-C motif chemokine 2 (CCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [79]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [80]
Gefitinib DM15F0X Colon adenocarcinoma Approved [81]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [82]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [83]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [84]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [85]
Methotrexate DM2TEOL Anterior urethra cancer Approved [69]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [86]
Quercetin DM3NC4M Obesity 5B81 Approved [87]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [88]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [89]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [90]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [91]
Gefitinib DM15F0X Colon adenocarcinoma Approved [92]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [93]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [94]
Selenium DM25CGV N. A. N. A. Approved [95]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [66]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [96]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [97]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [98]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [50]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [99]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [100]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [101]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [102]
Gefitinib DM15F0X Colon adenocarcinoma Approved [103]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [104]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [105]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [106]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [98]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [107]
Paclitaxel DMLB81S Breast carcinoma Approved [108]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [109]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [97]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [110]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [111]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [99]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [100]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CD70 antigen (CD70)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [112]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [113]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [64]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [114]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [115]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [58]
Menthol DMG2KW7 Back pain ME84.Z Approved [116]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [117]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [118]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [119]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [120]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [121]
Gamolenic acid DMQN30Z Allergy 4A80-4A85 Approved [122]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [123]
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [124]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [125]
Ibandronate DM0QZBN Hypercalcaemia 5B91.0 Approved [126]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [80]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [127]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [128]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [77]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [110]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [129]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [130]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [131]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [132]
Quercetin DM3NC4M Obesity 5B81 Approved [133]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [134]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [78]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [135]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Melanocyte protein PMEL (PMEL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluoxetine DM3PD2C Bipolar depression Approved [136]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [53]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [137]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [138]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [139]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [140]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [141]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [142]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [143]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [144]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [118]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [145]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [145]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [141]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [146]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [112]
⏷ Show the Full List of 6 Drug(s)
Drug(s) Affected By Thyroxine 5-deiodinase (DIO3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [147]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [84]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [115]
Ergocalciferol DMHO0AR Hypoparathyroidism 5A50 Approved [148]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [147]
Masoprocol DMMVNZ0 Prostate cancer 2C82.0 Approved [148]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [147]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [149]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [147]
Bicalutamide DMZMSPF Prostate cancer 2C82.0 Approved [150]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [137]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [57]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [151]
PDX-101 DM6OC53 Plasma cell myeloma 2A83.1 Phase 2 [143]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [152]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [112]
⏷ Show the Full List of 6 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [153]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [154]
Prednisone DM2HG4X Acute asthma CA23 Approved [155]
Triamterene DM2HU9I Congestive heart failure BD10 Approved [155]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [156]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [157]
Epinephrine DM3KJBC Acute asthma CA23 Approved [158]
Quercetin DM3NC4M Obesity 5B81 Approved [159]
Fluoxetine DM3PD2C Bipolar depression Approved [136]
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [160]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By GTPase KRas (KRAS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [161]
Quercetin DM3NC4M Obesity 5B81 Approved [162]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [137]
Tiazofurin DM5JWV9 Solid tumour/cancer 2A00-2F9Z Approved [163]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [164]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [165]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [166]
Testosterone enanthate DMB6871 N. A. N. A. Approved [167]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [168]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [169]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [178]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [179]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [61]
Gefitinib DM15F0X Colon adenocarcinoma Approved [180]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [181]
Selenium DM25CGV N. A. N. A. Approved [95]
Etretinate DM2CZFA Keratosis ED56 Approved [182]
Methotrexate DM2TEOL Anterior urethra cancer Approved [69]
Quercetin DM3NC4M Obesity 5B81 Approved [133]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [183]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By GTPase NRas (NRAS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [184]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [185]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [186]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [166]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [173]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [115]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [58]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [118]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [187]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [175]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Serine/threonine-protein kinase B-raf (BRAF) TTWCGQT BRAF_HUMAN Modulator [2]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Organic anion transporting polypeptide 1B1 (SLCO1B1) DT3D8F0 SO1B1_HUMAN Substrate [3]
Organic anion transporting polypeptide 1B3 (SLCO1B3) DT9C1TS SO1B3_HUMAN Substrate [3]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [4]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) Main DME DE4LYSA CP3A4_HUMAN Substrate [5]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
5,6-dihydroxyindole-2-carboxylic acid oxidase OTRK49R4 TYRP1_HUMAN Gene/Protein Processing [6]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Gene/Protein Processing [7]
CD70 antigen (CD70) OTHB2AL1 CD70_HUMAN Gene/Protein Processing [8]
Cyclin-dependent kinase 4 (CDK4) OT7EP05T CDK4_HUMAN Gene/Protein Processing [9]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Gene/Protein Processing [9]
GTPase KRas (KRAS) OT78QCN8 RASK_HUMAN Drug Response [10]
GTPase NRas (NRAS) OTVQ1DG3 RASN_HUMAN Drug Response [10]
Heat shock 70 kDa protein 1A (HSPA1A) OTKGIE76 HS71A_HUMAN Drug Response [11]
Hypoxia-inducible factor 1-alpha (HIF1A) OTADSC03 HIF1A_HUMAN Gene/Protein Processing [7]
Melanocyte protein PMEL (PMEL) OTCDDHHM PMEL_HUMAN Gene/Protein Processing [6]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5893).
2 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
3 Contribution of OATP1B1 and OATP1B3 to the disposition of sorafenib and sorafenib-glucuronide. Clin Cancer Res. 2013 Mar 15;19(6):1458-66.
4 Differential effects of the oncogenic BRAF inhibitor PLX4032 (vemurafenib) and its progenitor PLX4720 on ABCB1 function. J Pharm Pharm Sci. 2014;17(1):154-68.
5 Vemurafenib for the treatment of melanoma. Expert Opin Pharmacother. 2012 Dec;13(17):2533-43.
6 PLX4032 Mediated Melanoma Associated Antigen Potentiation in Patient Derived Primary Melanoma Cells. J Cancer. 2015 Oct 29;6(12):1320-30. doi: 10.7150/jca.11126. eCollection 2015.
7 Overcoming melanoma resistance to vemurafenib by targeting CCL2-induced miR-34a, miR-100 and miR-125b. Oncotarget. 2016 Jan 26;7(4):4428-41. doi: 10.18632/oncotarget.6599.
8 Melanoma Expressed-CD70 Is Regulated by RhoA and MAPK Pathways without Affecting Vemurafenib Treatment Activity. PLoS One. 2016 Feb 1;11(2):e0148095. doi: 10.1371/journal.pone.0148095. eCollection 2016.
9 Role of the protein kinase BRAF in the pathogenesis of endometriosis. Expert Opin Ther Targets. 2016 Aug;20(8):1017-29. doi: 10.1080/14728222.2016.1180367. Epub 2016 May 4.
10 Paradoxical activation of MEK/ERK signaling induced by B-Raf inhibition enhances DR5 expression and DR5 activation-induced apoptosis in Ras-mutant cancer cells. Sci Rep. 2016 May 25;6:26803. doi: 10.1038/srep26803.
11 HSP70 Inhibition Limits FAK-Dependent Invasion and Enhances the Response to Melanoma Treatment with BRAF Inhibitors. Cancer Res. 2016 May 1;76(9):2720-30. doi: 10.1158/0008-5472.CAN-15-2137. Epub 2016 Mar 16.
12 Clinical pipeline report, company report or official report of GlaxoSmithKline (2011).
13 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
14 Identification of PLX4032-resistance mechanisms and implications for novel RAF inhibitors. Pigment Cell Melanoma Res. 2014 Mar;27(2):253-62.
15 Clinical pipeline report, company report or official report of Ambit Biosciences.
16 BGB-283, a Novel RAF Kinase and EGFR Inhibitor, Displays Potent Antitumor Activity in BRAF-Mutated Colorectal Cancers. Mol Cancer Ther. 2015 Oct;14(10):2187-97.
17 National Cancer Institute Drug Dictionary (drug id 688029).
18 National Cancer Institute Drug Dictionary (drug id 680347).
19 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
20 Clinical pipeline report, company report or official report of Exelixis (2011).
21 Clinical pipeline report, company report or official report of ABM Therapeutics.
22 Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007.
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