Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMH0ZJE)

• Drug Name: Mitomycin Drug Info
• Synonyms: Mitomycin C; mitomycin C; 1950/7/7; Mutamycin; Ametycine; Mitocin-C; Ametycin; Mitomycin-C; Mytozytrex; Mitomycinum; Mytomycin; Mitozytrex; Mitomycinum C; Mitocin C; Mitomycins; Mitamycin; MMC; Mitosol; Mitomycyna C; 7-Amino-9alpha-methoxymitosane; NSC-26980; Mitomycyna C [Polish]; Mito-C; Mit-C; Mitomycin (TN); Mitomycinum [INN-Latin]; Mitomycine [INN-French]; Mitomicina [INN-Spanish]; NCI-C04706; RCRA waste number U010; NSC26980; NSC 26980; Mitomycine; CCRIS 414; UNII-50SG953SK6; HSDB 3239; C15H18N4O5; EINECS 200-008-6; Mitomycin C,; Ametycin; Mitomicina; Muamycin; Mitomycin C from Streptomyces caespitosus; Mitomycin C (JP15); Mitomycin C, Streptomyces caespitosus; Muamycin (TN); Mitomycin (USP/INN); Mitomycin [USAN:INN:BAN]; Mitomycin C, Streptomyces caespitosus, Carrier-Free

Indication

Disease Entry	ICD 11	Status	REF
Breast cancer	2C60-2C65	Approved	[1]
Gastrointestinal cancer	2C11	Approved	[1]
Pancreatic adenocarcinoma		Approved	[2]
Solid tumour/cancer	2A00-2F9Z	Approved	[3]
Urinary bladder cancer		Approved	[2]
Urinary bladder neoplasm		Approved	[2]
Urinary system neoplasm		Approved	[2]
Urinary tract disease	GC2Z	Approved	[2]
Bladder disease	DC11-DC1Z	Investigative	[2]
Colon cancer	2B90.Z	Investigative	[2]

• Therapeutic Class: Anticancer Agents
• Cross-matching ID:
  PubChem CID: 5746
  ChEBI ID: CHEBI:27504
  CAS Number: CAS 50-07-7
  TTD Drug ID: DMH0ZJE
  VARIDT Drug ID: DR01212
  ACDINA Drug ID: D01255

Molecule-Related Drug Atlas

Drug(s) Targeting Human Deoxyribonucleic acid (hDNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[9]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[10]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[11]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[12]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[13]
Carboplatin	DMG281S	Adenocarcinoma	2D40	Approved	[14]
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[15]
Procarbazine	DMIK367	Hodgkin lymphoma	2B30	Approved	[16]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[17]
Dacarbazine	DMNPZL4	Adenocarcinoma	2D40	Approved	[18]

Drug(s) Transported By P-glycoprotein 1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[19]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[20]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[21]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[22]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[21]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[21]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[23]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[21]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[24]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[25]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[26]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[27]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[28]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[29]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[30]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[31]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[32]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[33]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[34]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[32]

Drug(s) Affected By Alternative prion protein (PRNP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[35]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[38]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[42]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[42]
Bortezomib	DMNO38U	Leukemia		Approved	[43]

Drug(s) Affected By Amyloid-beta precursor protein (APP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[35]
Selenium	DM25CGV	N. A.	N. A.	Approved	[44]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[36]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[45]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[46]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[49]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[50]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[51]

Drug(s) Affected By HLA class I histocompatibility antigen, C alpha chain (HLA-C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[52]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[53]
Allopurinol	DMLPAOB	Gout	FA25	Approved	[54]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[55]
Ticlopidine	DMO946V	Acute coronary syndrome	BA41	Approved	[56]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[35]
Selenium	DM25CGV	N. A.	N. A.	Approved	[44]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]

Drug(s) Affected By Bone morphogenetic protein 4 (BMP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[59]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[60]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[35]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[38]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[66]

Drug(s) Affected By G2/mitotic-specific cyclin-B1 (CCNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[67]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[68]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[69]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[70]
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[72]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[73]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[74]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[75]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[76]

Drug(s) Affected By Early growth response protein 1 (EGR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[77]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[79]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[81]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[84]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[50]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[85]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-4 (ATF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[86]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[87]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[35]
Selenium	DM25CGV	N. A.	N. A.	Approved	[44]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[75]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[88]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[89]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[90]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[91]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[92]

Drug(s) Affected By DNA ligase 1 (LIG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[67]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[93]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[97]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[98]

Drug(s) Affected By Nuclear transcription factor Y subunit alpha (NFYA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[100]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[102]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[103]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[104]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[98]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[105]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[106]

Drug(s) Affected By Ephrin type-A receptor 2 (EPHA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[70]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[63]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[107]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[108]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[109]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[110]

Drug(s) Affected By Replication factor C subunit 4 (RFC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[67]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]

Drug(s) Affected By Matrix metalloproteinase-14 (MMP14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[112]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[38]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[113]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[114]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[115]
Cysteamine	DMSYFM8	Nephropathic cystinosis	5C60	Approved	[116]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[117]

Drug(s) Affected By Activated RNA polymerase II transcriptional coactivator p15 (SUB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[118]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[50]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[103]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[120]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[121]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[122]

Drug(s) Affected By Small ribosomal subunit protein eS1 (RPS3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[123]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[124]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[125]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[98]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[126]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[127]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[128]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[129]

Drug(s) Affected By Microtubule-associated protein RP/EB family member 1 (MAPRE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[108]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[130]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[130]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[131]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[98]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[122]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[133]

Drug(s) Affected By Histone-binding protein RBBP7 (RBBP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[134]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Promegestone	DMK4S8I	Gynecological disease	GA6Z	Approved	[135]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[109]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[98]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[134]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[133]

Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[136]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[137]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[138]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[139]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[140]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[141]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[142]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[60]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[143]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[144]

Drug(s) Affected By TP53-regulated inhibitor of apoptosis 1 (TRIAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[145]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[63]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[101]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[146]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[146]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[146]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[146]

Drug(s) Affected By Superoxide dismutase (SOD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[147]
Haloperidol	DM96SE0	Delirium		Approved	[148]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[149]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[69]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[150]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[151]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[152]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[153]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[154]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[155]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[156]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[36]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[157]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[158]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[159]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[160]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[161]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[162]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[163]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[164]

Drug(s) Affected By Heat shock cognate 71 kDa protein (HSPA8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[165]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[86]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[134]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[123]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[166]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[167]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[168]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[169]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[85]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[170]

Drug(s) Affected By Proliferating cell nuclear antigen (PCNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[59]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[171]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[123]
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[172]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[173]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[174]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[175]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[176]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[177]

Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[77]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[86]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[178]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[179]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[75]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[180]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[84]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[181]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[182]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[183]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[184]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[69]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[185]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[186]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[72]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[187]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[73]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[145]

Drug(s) Affected By Quinone oxidoreductase PIG3 (TP53I3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[188]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[175]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Amifostine	DM5FL14	Mucositis	CA00	Approved	[190]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[107]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[191]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[146]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[146]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]

Drug(s) Affected By DNA damage-binding protein 2 (DDB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[70]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[192]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[63]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[101]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[146]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[146]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[61]

Drug(s) Affected By Cystine/glutamate transporter (SLC7A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[193]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[143]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[194]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[143]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[143]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[195]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[196]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[197]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[143]

Drug(s) Affected By Succinate dehydrogenase assembly factor 1, mitochondrial (SDHAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[145]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[101]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[145]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[145]
Adenine	DMZLHKJ	Malnutrition	5B50-5B71	Approved	[145]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[198]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[199]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[200]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[201]

Drug(s) Affected By Serine/threonine-protein kinase Sgk1 (SGK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[202]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[203]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[204]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[145]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[197]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[202]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[205]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[63]

Drug(s) Affected By E3 ubiquitin-protein ligase TRIM38 (TRIM38)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[44]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[145]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[206]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[207]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[38]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[208]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[107]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[39]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[101]

Drug(s) Affected By Torsin-1A (TOR1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[145]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[102]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[109]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[145]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[145]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[98]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[145]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[122]

Drug(s) Affected By Telomerase reverse transcriptase (TERT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[209]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[210]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[211]
Selenium	DM25CGV	N. A.	N. A.	Approved	[212]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[213]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[215]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[216]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[217]

Drug(s) Affected By Serine/threonine-protein kinase Chk1 (CHEK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[67]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[218]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[219]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[220]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[207]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[221]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[222]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[223]

Drug(s) Affected By Transcription factor EC (TFEC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[100]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[145]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[145]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[145]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[224]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[225]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[226]

Drug(s) Affected By Regulator of G-protein signaling 16 (RGS16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[70]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[145]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[77]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[227]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[103]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[228]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[145]

Drug(s) Affected By E3 ubiquitin-protein ligase RNF113A (RNF113A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[145]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[229]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[145]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[145]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[145]
Adenine	DMZLHKJ	Malnutrition	5B50-5B71	Approved	[145]

Drug(s) Affected By HMG box-containing protein 1 (HBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[70]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[230]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[50]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]

Drug(s) Affected By Kinesin-like protein KIF20A (KIF20A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[134]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[70]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[145]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[76]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[101]

Drug(s) Affected By Myelin protein zero-like protein 1 (MPZL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[79]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[229]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[115]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[145]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[145]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[98]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[145]

Drug(s) Affected By Serine/threonine-protein kinase Chk2 (CHEK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[231]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[67]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[232]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[221]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[233]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[217]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[234]

Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[235]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[148]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[236]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[237]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[238]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[239]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[240]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[241]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[242]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[36]

Drug(s) Affected By Interleukin-1 alpha (IL1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[59]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[143]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[143]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[243]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[143]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[36]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[219]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[143]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]

Drug(s) Affected By Thymidine kinase, cytosolic (TK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[244]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[245]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[246]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[247]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[93]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[248]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[249]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]

Drug(s) Affected By Plasminogen activator inhibitor 1 (SERPINE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[250]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[251]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[252]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[253]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[254]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[255]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[247]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[256]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[90]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[257]

Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[195]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[258]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[59]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[259]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[260]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[261]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[243]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[262]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[263]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[195]

Drug(s) Affected By Retinoblastoma-associated protein (RB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[264]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[265]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[266]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[186]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[35]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[267]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[268]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[218]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[269]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[270]

Drug(s) Affected By Fibroblast growth factor 2 (FGF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[271]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[184]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[272]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[273]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[274]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[275]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[207]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[233]
Isradipine	DMA5XGH	Hypertension	BA00-BA04	Approved	[276]
Valdecoxib	DMAY7H4	Osteoarthritis	FA00-FA05	Approved	[277]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[59]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[278]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[279]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[188]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[280]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[73]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[280]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[281]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[282]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[283]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[284]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[285]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[286]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[259]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[287]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[261]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[143]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[150]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[288]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[143]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[289]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[290]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[291]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[292]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[148]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[59]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[293]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[294]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[295]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[296]

Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[260]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[60]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[297]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[243]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[239]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[298]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[299]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[36]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[300]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[301]

Drug(s) Affected By CD59 glycoprotein (CD59)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[302]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[303]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[304]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]

Drug(s) Affected By Histone H2AX (H2AX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[305]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[306]
Selenium	DM25CGV	N. A.	N. A.	Approved	[44]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[307]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[308]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[309]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[196]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[310]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[311]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[312]

Drug(s) Affected By Beta-galactosidase (GLB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[67]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[313]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[314]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[175]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[315]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Bendamustine hydrochloride	DMFH15Z	leukaemia	2A60-2B33	Approved	[316]

Drug(s) Affected By rRNA 2'-O-methyltransferase fibrillarin (FBL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[317]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[317]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[317]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[122]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[129]

Drug(s) Affected By Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[145]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[247]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[318]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[319]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[320]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[149]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[188]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[321]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[322]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[323]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[324]
Fructose	DM43AN2	Vomiting	MD90	Approved	[325]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[197]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[66]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[326]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[327]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[295]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[328]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[329]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[330]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[331]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[332]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[333]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[334]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[326]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[335]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[336]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[337]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[66]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[148]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[302]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[295]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[328]

Drug(s) Affected By GTP cyclohydrolase 1 (GCH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[145]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[76]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[207]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[107]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[98]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[338]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[145]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[106]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[339]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[340]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[162]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[296]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[341]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[342]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[343]
Selenium	DM25CGV	N. A.	N. A.	Approved	[44]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[172]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[344]

Drug(s) Affected By Replication factor C subunit 1 (RFC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[145]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[229]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[345]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[346]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[145]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[145]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[106]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[122]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[347]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[348]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[349]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[159]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[350]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[351]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[352]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[353]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[354]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[355]

Drug(s) Affected By RNA-binding protein 34 (RBM34)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[145]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[108]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[145]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[356]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[145]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[356]
Adenine	DMZLHKJ	Malnutrition	5B50-5B71	Approved	[145]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[199]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 6 (FASLG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[225]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[357]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[358]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[322]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[359]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[81]
Fructose	DM43AN2	Vomiting	MD90	Approved	[325]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[360]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[361]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[362]

Drug(s) Affected By Glycogen synthase kinase-3 beta (GSK3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[165]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[266]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[363]
Selenium	DM25CGV	N. A.	N. A.	Approved	[44]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[364]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[365]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[219]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[366]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[89]

Drug(s) Affected By LIM/homeobox protein Lhx2 (LHX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[145]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[207]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[145]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[145]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[98]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[367]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[145]
Adenine	DMZLHKJ	Malnutrition	5B50-5B71	Approved	[145]

Drug(s) Affected By DNA mismatch repair protein Msh6 (MSH6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[67]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[70]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[145]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[103]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]

Drug(s) Affected By RecQ-like DNA helicase BLM (BLM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[67]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[70]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[145]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]

Drug(s) Affected By Ataxin-1 (ATXN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[225]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[194]
Selenium	DM25CGV	N. A.	N. A.	Approved	[44]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[145]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[207]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[368]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[146]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[146]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[146]

Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[369]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[370]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[59]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[294]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[371]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[372]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[188]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[373]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[374]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[375]

Drug(s) Affected By Ras-related protein Rap-2b (RAP2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[145]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[207]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[145]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[98]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[145]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Adenine	DMZLHKJ	Malnutrition	5B50-5B71	Approved	[145]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[198]

Drug(s) Affected By Cytochrome c (CYCS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[302]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[376]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[278]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[371]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[377]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[378]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[36]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[379]
Pefloxacin	DM49IGF	Gonococcal urethritis	1A70.0Y	Approved	[380]

Drug(s) Affected By E3 ubiquitin-protein ligase Mdm2 (MDM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[302]
Flucytosine	DM13VTW	Cryptococcal meningitis		Approved	[381]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[381]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[382]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[175]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[383]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[157]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[230]
Amifostine	DM5FL14	Mucositis	CA00	Approved	[190]

Drug(s) Affected By Transcription factor E2F1 (E2F1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[384]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[59]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[385]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[210]
Selenium	DM25CGV	N. A.	N. A.	Approved	[44]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[145]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[268]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[176]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[46]

Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[302]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[296]
Selenium	DM25CGV	N. A.	N. A.	Approved	[44]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[386]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[387]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[388]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[389]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[390]

Drug(s) Affected By Protein kinase C zeta type (PRKCZ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[107]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[109]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[106]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[391]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[122]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[392]
Carbachol	DMX9K8F	Glaucoma/ocular hypertension	9C61	Approved	[393]

Drug(s) Affected By DNA repair protein RAD51 homolog 1 (RAD51)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[67]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[394]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[395]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[396]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[397]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Quizartinib	DM8Y4JS	Acute myeloid leukaemia	2A60	Approved	[398]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[101]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[289]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[355]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[59]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[293]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[149]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[371]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[186]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[35]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[174]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[73]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[162]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[399]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[188]
Selenium	DM25CGV	N. A.	N. A.	Approved	[44]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[400]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[175]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[381]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[401]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[219]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[81]

Drug(s) Affected By Tripartite motif-containing protein 26 (TRIM26)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[145]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[109]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[402]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[145]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[70]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[106]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[126]

Drug(s) Affected By E3 ubiquitin-protein ligase TRIM32 (TRIM32)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[145]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[101]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[145]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[98]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[145]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[126]
Adenine	DMZLHKJ	Malnutrition	5B50-5B71	Approved	[145]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[198]

Drug(s) Affected By Chromatin assembly factor 1 subunit A (CHAF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[145]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[229]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[207]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[403]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[109]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[145]

Drug(s) Affected By Chromatin assembly factor 1 subunit B (CHAF1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[145]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[98]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[145]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[126]

Drug(s) Affected By Interleukin-18 (IL18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[302]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[35]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[36]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[404]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[405]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[406]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[345]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[407]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[408]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[407]

Drug(s) Affected By Protein BTG3 (BTG3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[145]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[409]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[121]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[145]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[145]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[98]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[410]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[411]

Drug(s) Affected By Histone RNA hairpin-binding protein (SLBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[225]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[123]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[145]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[46]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[107]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[412]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[145]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[145]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[145]

Drug(s) Affected By Caspase-8 (CASP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[413]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[414]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[415]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[302]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[357]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[416]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[188]
Selenium	DM25CGV	N. A.	N. A.	Approved	[44]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[374]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[36]

Drug(s) Affected By Transforming growth factor-beta-induced protein ig-h3 (TGFBI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[345]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[417]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[200]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[98]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[418]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[419]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[106]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[420]

Drug(s) Affected By Neutral amino acid transporter B(0) (SLC1A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[145]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[146]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[146]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[146]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[146]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[145]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[421]

Drug(s) Affected By Protein MCM10 homolog (MCM10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[67]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[70]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[145]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[93]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[422]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[108]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[423]

Drug(s) Affected By Partner and localizer of BRCA2 (PALB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[145]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[108]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[145]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[98]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[145]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[55]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[122]
Adenine	DMZLHKJ	Malnutrition	5B50-5B71	Approved	[145]

Drug(s) Affected By Leucine-rich repeat-containing protein 47 (LRRC47)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[145]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[424]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[109]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[145]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[145]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[145]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[122]
Adenine	DMZLHKJ	Malnutrition	5B50-5B71	Approved	[145]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[44]

Drug(s) Affected By Bcl2-associated agonist of cell death (BAD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[425]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[355]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[302]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[426]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[427]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[428]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[247]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[429]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[257]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[217]

Drug(s) Affected By Cytochrome c oxidase assembly factor 7 (COA7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[70]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[145]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[109]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[145]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[145]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[98]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[145]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[430]

Drug(s) Affected By Mitochondrial potassium channel (CCDC51)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[145]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[145]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[145]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[98]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[145]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[430]
Adenine	DMZLHKJ	Malnutrition	5B50-5B71	Approved	[145]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[40]

Drug(s) Affected By Integrator complex subunit 15 (INTS15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[44]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[145]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[109]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[145]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[145]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[145]
Adenine	DMZLHKJ	Malnutrition	5B50-5B71	Approved	[145]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[198]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[44]

Drug(s) Affected By Krueppel-like factor 6 (KLF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[59]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[431]
Selenium	DM25CGV	N. A.	N. A.	Approved	[44]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[145]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[176]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[46]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[38]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]

Drug(s) Affected By Cell division control protein 6 homolog (CDC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[67]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[145]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[176]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[118]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[432]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]

Drug(s) Affected By Growth/differentiation factor 15 (GDF15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[77]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[145]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[75]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[118]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[433]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[434]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[434]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[435]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[436]

Drug(s) Affected By Protein orai-3 (ORAI3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[70]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[145]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[146]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[146]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[146]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[403]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[98]

Drug(s) Affected By Protein pelota homolog (PELO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[145]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[437]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[438]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[145]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[145]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[98]

Drug(s) Affected By TIMELESS-interacting protein (TIPIN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[145]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[439]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[440]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[145]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[145]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[145]

Drug(s) Affected By Fanconi anemia group D2 protein (FANCD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[67]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[76]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[441]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[102]

Drug(s) Affected By tRNA pseudouridine(38/39) synthase (PUS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[70]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[145]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[109]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[145]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[145]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[98]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[145]

Drug(s) Affected By Transmembrane protein 185B (TMEM185B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[70]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[145]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[145]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[145]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[145]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[126]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[442]

Drug(s) Affected By Interferon-stimulated 20 kDa exonuclease-like 2 (ISG20L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[145]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[145]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[145]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[145]
Indomethacin	DMSC4A7	Bursitis		Approved	[443]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[70]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[442]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[122]
Adenine	DMZLHKJ	Malnutrition	5B50-5B71	Approved	[145]

Drug(s) Affected By GrpE protein homolog 1, mitochondrial (GRPEL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[145]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[444]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[319]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[145]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[145]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[98]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[145]

Drug(s) Affected By Forkhead box protein J2 (FOXJ2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[145]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[145]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[145]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[145]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[122]
Adenine	DMZLHKJ	Malnutrition	5B50-5B71	Approved	[145]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[229]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[225]

Drug(s) Affected By Homologous-pairing protein 2 homolog (PSMC3IP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[145]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[100]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[108]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[403]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[440]

Drug(s) Affected By rRNA methyltransferase 2, mitochondrial (MRM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[145]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[403]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[109]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[145]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[145]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[98]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[145]

Drug(s) Affected By Frizzled-1 (FZD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[145]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[50]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[445]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[145]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[145]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[302]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[261]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[446]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[143]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[150]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[143]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[262]
Selenium	DM25CGV	N. A.	N. A.	Approved	[447]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[448]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[449]

Drug(s) Affected By Tripartite motif-containing protein 2 (TRIM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[225]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[70]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[75]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[207]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[109]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[98]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[70]

Drug(s) Affected By Acid ceramidase (ASAH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[450]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[149]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[451]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[452]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[450]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[451]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[450]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[207]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[451]

Drug(s) Affected By Fanconi-associated nuclease 1 (FAN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[44]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[453]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[345]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[108]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[130]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[109]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[98]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[122]

Drug(s) Affected By Replication factor C subunit 3 (RFC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[67]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[454]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[102]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[440]

Drug(s) Affected By CD9 antigen (CD9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[455]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[456]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[38]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[109]
Bortezomib	DMNO38U	Leukemia		Approved	[43]

Drug(s) Affected By KN motif and ankyrin repeat domain-containing protein 1 (KANK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[109]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[200]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[98]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[457]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[70]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[442]

Drug(s) Affected By Aldehyde oxidase (AOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[79]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[458]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[195]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[90]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[38]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[440]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[109]

Drug(s) Affected By Mitochondrial fission 1 protein (FIS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[459]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[460]
Selenium	DM25CGV	N. A.	N. A.	Approved	[44]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[461]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[109]
ANGIOTENSIN II	DMLWQ27	Increase blood pressure	BA04	Approved	[462]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[463]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[464]

Drug(s) Affected By Cytoplasmic aconitate hydratase (ACO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[225]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[70]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[319]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[108]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Gallium nitrate	DMF9O6B	Hypercalcaemia	5B91.0	Approved	[465]
Trabectedin	DMG3Y89	Leiomyosarcoma	2B58	Approved	[466]

Drug(s) Affected By Syncytin-2 (ERVFRD-1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[467]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[468]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[6]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[6]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[469]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[468]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[470]
Forskolin	DM6ITNG	Solid tumour/cancer	2A00-2F9Z	Investigative	[471]
Anandamide	DMCKH3P	Discovery agent	N.A.	Investigative	[472]

Drug(s) Affected By Protein FAM171A1 (FAM171A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[109]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[104]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[473]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[106]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[6]

Drug(s) Affected By Sister chromatid cohesion protein PDS5 homolog A (PDS5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[474]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[122]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[475]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[476]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[229]

Drug(s) Affected By Excitatory amino acid transporter 3 (SLC1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[44]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[207]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[477]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[70]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[478]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[479]

Drug(s) Affected By Syntabulin (SYBU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[70]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[480]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[481]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[98]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[106]

Drug(s) Affected By Fatty acid CoA ligase Acsl3 (ACSL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[482]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[319]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[107]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[483]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[484]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[485]

Drug(s) Affected By Prelamin-A/C (LMNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[44]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[175]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[388]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[167]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[486]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[487]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[103]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]

Drug(s) Affected By Methylated-DNA--protein-cysteine methyltransferase (MGMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[488]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[489]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[490]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[491]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[492]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[493]
Dacarbazine	DMNPZL4	Adenocarcinoma	2D40	Approved	[494]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[495]

Drug(s) Affected By Pyridoxal kinase (PDXK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[319]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[439]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[109]
Bortezomib	DMNO38U	Leukemia		Approved	[43]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[98]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[70]

Drug(s) Affected By Proteinase-activated receptor 1 (F2R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[69]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[35]
Selenium	DM25CGV	N. A.	N. A.	Approved	[44]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[496]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[497]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[480]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[498]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[498]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]

Drug(s) Affected By Diamine acetyltransferase 1 (SAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[70]
Selenium	DM25CGV	N. A.	N. A.	Approved	[44]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[499]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[76]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[38]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[500]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[500]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[101]

Drug(s) Affected By Breast cancer type 1 susceptibility protein (BRCA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[59]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[501]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[502]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[386]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[175]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[220]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[50]

Drug(s) Affected By Neprilysin (MME)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[503]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[207]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[504]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[505]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[109]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[506]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[430]

Drug(s) Affected By Lymphokine-activated killer T-cell-originated protein kinase (PBK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[76]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[507]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]

Drug(s) Affected By Protein-glutamine gamma-glutamyltransferase 2 (TGM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[149]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[508]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[509]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[422]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[510]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[511]

Drug(s) Affected By G-protein-signaling modulator 2 (GPSM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[452]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[76]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[439]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[423]
Promegestone	DMK4S8I	Gynecological disease	GA6Z	Approved	[135]

Drug(s) Affected By Dual specificity protein phosphatase 4 (DUSP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[59]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[319]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[38]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[57]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[107]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[345]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[103]

Drug(s) Affected By Interferon-induced GTP-binding protein Mx1 (MX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[44]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[195]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[195]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[169]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[512]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[480]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[107]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[513]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[439]

Drug(s) Affected By Plasminogen activator inhibitor 2 (SERPINB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[59]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[261]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[434]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[434]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[514]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[515]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[119]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]

Drug(s) Affected By Transcriptional regulator ATRX (ATRX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[194]
Selenium	DM25CGV	N. A.	N. A.	Approved	[44]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[100]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[439]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[516]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[120]

Drug(s) Affected By Monocarboxylate transporter 7 (SLC16A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[75]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[477]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[230]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[480]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[517]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[146]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]

Drug(s) Affected By Ras-related protein Rab-17 (RAB17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[38]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[227]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[98]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[430]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[518]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[108]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[6]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[38]

Drug(s) Affected By Stanniocalcin-2 (STC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[59]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[251]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[75]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[519]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[520]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[77]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[521]

Drug(s) Affected By Pirin (PIR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[70]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[434]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[319]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[211]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[63]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[146]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[146]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[522]

Drug(s) Affected By Myelin proteolipid protein (PLP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[207]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[38]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[519]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[417]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[120]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[523]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[524]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[524]

Drug(s) Affected By Protein-S-isoprenylcysteine O-methyltransferase (ICMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[525]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[98]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[129]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[199]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[470]

Drug(s) Affected By G0/G1 switch protein 2 (G0S2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[70]
Selenium	DM25CGV	N. A.	N. A.	Approved	[447]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[206]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[168]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[526]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[480]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[39]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]

Drug(s) Affected By Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform (PPP2R5E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[98]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[122]
Camptothecin	DM6CHNJ	Solid tumour/cancer	2A00-2F9Z	Phase 3	[527]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[528]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[229]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[229]

Drug(s) Affected By cAMP-dependent protein kinase inhibitor alpha (PKIA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[480]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[438]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[481]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[109]
Bortezomib	DMNO38U	Leukemia		Approved	[43]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[106]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[430]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[122]

Drug(s) Affected By Melanoma-associated antigen 12 (MAGEA12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[109]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[419]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[529]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[6]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[199]

Drug(s) Affected By Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform (PPP2R2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[225]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[103]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[402]
Bortezomib	DMNO38U	Leukemia		Approved	[43]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[98]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[530]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[531]

Drug(s) Affected By Tissue factor pathway inhibitor (TFPI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[202]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[207]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[38]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[202]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[532]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[103]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[120]

Drug(s) Affected By Acyl-coenzyme A thioesterase 2, mitochondrial (ACOT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[44]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[319]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[130]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[130]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[533]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[98]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[126]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[122]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[198]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[534]

Drug(s) Affected By Aldehyde dehydrogenase, dimeric NADP-preferring (ALDH3A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[535]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[176]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[536]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[537]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[480]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[320]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[109]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[457]

Drug(s) Affected By Long-chain-fatty-acid--CoA ligase 1 (ACSL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[225]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[70]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[247]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[207]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[38]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[92]
Tolcapone	DM8MNVO	Parkinson disease	8A00.0	Approved	[538]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[146]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[146]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[146]

Drug(s) Affected By Cyclin-dependent kinase 2 (CDK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[67]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[68]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[385]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[539]
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[73]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[540]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[541]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[542]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[270]

Drug(s) Affected By Cochlin (COCH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[319]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[146]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[146]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[146]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[146]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[98]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[457]

Drug(s) Affected By ETS domain-containing protein Elk-3 (ELK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[207]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[98]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[420]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[122]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[38]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[38]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[543]

Drug(s) Affected By High mobility group protein HMGI-C (HMGA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[184]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[103]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[440]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[228]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[98]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[473]

Drug(s) Affected By Protein PRRC2C (PRRC2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[225]
Selenium	DM25CGV	N. A.	N. A.	Approved	[44]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[229]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[544]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[439]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[98]

Drug(s) Affected By Melanocyte protein PMEL (PMEL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[482]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[207]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[319]
Vemurafenib	DM62UG5	Melanoma	2C30	Approved	[545]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[367]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[457]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[55]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[442]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[546]

Drug(s) Affected By BMP and activin membrane-bound inhibitor homolog (BAMBI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[455]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[38]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[57]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[480]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[103]

Drug(s) Affected By Creatine kinase U-type, mitochondrial (CKMT1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[525]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[547]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[6]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[6]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[6]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[548]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[199]
dibutyl phthalate	DMEDGKO	Discovery agent	N.A.	Investigative	[549]

Drug(s) Affected By Sodium/potassium-transporting ATPase subunit alpha-1 (ATP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Reserpine	DM6VM38	Hypertension	BA00-BA04	Approved	[148]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[481]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[550]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[457]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[126]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[551]

Drug(s) Affected By CD166 antigen (ALCAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[302]
Selenium	DM25CGV	N. A.	N. A.	Approved	[44]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[207]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[319]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[38]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[208]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[109]

Drug(s) Affected By Cytochrome c oxidase copper chaperone (COX17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[43]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[98]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[552]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[553]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[122]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[6]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[6]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[6]
Coprexa	DMA0WEK	Neurological disorder	6B60	Phase 3	[554]

Drug(s) Affected By Interleukin-6 receptor subunit alpha (IL6R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[555]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[247]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[556]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[439]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[417]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[557]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[558]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[412]

Drug(s) Affected By Collagen alpha-3(IX) chain (COL9A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[70]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[38]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[108]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[6]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[38]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[40]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[559]

Drug(s) Affected By A-kinase anchor protein 12 (AKAP12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[455]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[206]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[93]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[38]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[534]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[298]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[39]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[101]

Drug(s) Affected By Dystrophin (DMD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[225]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Thioguanine	DM7NKEV	Acute lymphocytic leukaemia	2B33.3	Approved	[560]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[103]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[561]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[562]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[563]

Drug(s) Affected By Dickkopf-related protein 3 (DKK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[225]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[50]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[345]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[564]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[109]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[421]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[98]

Drug(s) Affected By dTDP-D-glucose 4,6-dehydratase (TGDS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[133]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[6]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[199]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[476]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[565]

Drug(s) Affected By Calmegin (CLGN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[195]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[207]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[195]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[38]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[534]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[39]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[516]

Drug(s) Affected By Ras association domain-containing protein 1 (RASSF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[44]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[566]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[108]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[564]
Procainamide	DMNMXR8	Ventricular arrhythmias	BC71	Approved	[567]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[568]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[411]

Drug(s) Affected By Protocadherin Fat 1 (FAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[569]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[570]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[109]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[98]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[571]

Drug(s) Affected By Midkine (MDK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[44]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[572]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[573]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[109]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[200]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[574]

Drug(s) Affected By Serine/arginine-rich splicing factor 1 (SRSF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[134]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[70]
Selenium	DM25CGV	N. A.	N. A.	Approved	[44]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[525]
Bortezomib	DMNO38U	Leukemia		Approved	[43]

Drug(s) Affected By Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (PPP2R5C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[575]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[530]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[106]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[122]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[530]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[6]
Camptothecin	DM6CHNJ	Solid tumour/cancer	2A00-2F9Z	Phase 3	[527]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[576]

Drug(s) Affected By G antigen 7 (GAGE7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[577]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[6]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[199]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[226]
methyl p-hydroxybenzoate	DMO58UW	Discovery agent	N.A.	Investigative	[578]

Drug(s) Affected By Serglycin (SRGN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[519]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[544]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[103]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[109]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[579]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[402]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[98]

Drug(s) Affected By Catenin alpha-1 (CTNNA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[35]
Selenium	DM25CGV	N. A.	N. A.	Approved	[44]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[79]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[118]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[580]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[211]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[580]
Haloperidol	DM96SE0	Delirium		Approved	[130]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[108]

Drug(s) Affected By Sortilin (SORT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[130]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[319]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[581]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[109]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[200]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 2 (BIRC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[582]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[355]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[401]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[583]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[584]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[585]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[586]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[587]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[588]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[589]

Drug(s) Affected By Myelin basic protein (MBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[590]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[107]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[101]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[417]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[591]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[592]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[200]

Drug(s) Affected By Tudor domain-containing protein 3 (TDRD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[79]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[345]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[367]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[367]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[126]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[122]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[6]

Drug(s) Affected By Enhancer of filamentation 1 (NEDD9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[434]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[434]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[146]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[101]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[146]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[146]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[146]

Drug(s) Affected By Squalene synthase (FDFT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[593]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[482]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[319]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[101]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[594]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[320]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]

Drug(s) Affected By Multidrug resistance-associated protein 1 (ABCC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[595]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[596]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[597]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[598]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[599]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[418]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[600]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[601]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[602]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[602]

Drug(s) Affected By Sigma intracellular receptor 2 (TMEM97)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[319]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[50]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[480]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[107]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[481]

Drug(s) Affected By Transmembrane protein 156 (TMEM156)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[345]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[109]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[6]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[6]
PD-0325901	DM27D4J	Breast cancer	2C60-2C65	Phase 2	[603]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[604]

Drug(s) Affected By Probable JmjC domain-containing histone demethylation protein 2C (JMJD1C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[544]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[103]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[457]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[106]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[122]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[129]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[528]

Drug(s) Affected By Unconventional myosin-X (MYO10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[207]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[101]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[504]
Promegestone	DMK4S8I	Gynecological disease	GA6Z	Approved	[135]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[98]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[457]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[70]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[420]

Drug(s) Affected By Tribbles homolog 2 (TRIB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[44]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[115]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[109]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[418]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[605]

Drug(s) Affected By Actin-binding LIM protein 1 (ABLIM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[229]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[50]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[115]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[109]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[411]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[606]

Drug(s) Affected By DNA damage-inducible transcript 4 protein (DDIT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[77]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[452]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[145]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[607]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[608]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[207]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[230]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[233]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[520]

Drug(s) Affected By Protein S100-A11 (S100A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[44]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[36]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[207]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[38]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[50]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[512]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[544]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[609]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]

Drug(s) Affected By Protein S100-A10 (S100A10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[38]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[610]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[609]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[504]

Drug(s) Affected By Melanoma-associated antigen 6 (MAGEA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[611]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[529]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[6]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[6]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[6]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[612]

Drug(s) Affected By Runt-related transcription factor 3 (RUNX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[613]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[614]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[613]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[615]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[613]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[616]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[613]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[106]

Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[617]
Selenium	DM25CGV	N. A.	N. A.	Approved	[447]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[195]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[618]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[154]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[619]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[458]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[247]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[620]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[93]

Drug(s) Affected By Nuclear receptor-interacting protein 1 (NRIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[60]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[93]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[38]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[39]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[516]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[511]
Teniposide	DMLW57T	Acute lymphoblastic leukaemia	2A85	Approved	[621]

Drug(s) Affected By Protein c-Fos (FOS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[50]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[184]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[622]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[86]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[622]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[171]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[35]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[623]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[624]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[625]

Drug(s) Affected By Trefoil factor 3 (TFF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[503]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[626]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[70]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[627]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[55]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[503]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[628]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[6]

Drug(s) Affected By Collagen alpha-2(IV) chain (COL4A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[149]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[580]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[319]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[580]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[439]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[149]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[440]

Drug(s) Affected By Hairy/enhancer-of-split related with YRPW motif protein 1 (HEY1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[207]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[629]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[630]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[109]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[104]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[412]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[98]

Drug(s) Affected By E3 ubiquitin-protein ligase MYLIP (MYLIP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[207]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[38]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[480]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[109]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[98]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]

Drug(s) Affected By Hematopoietically-expressed homeobox protein HHEX (HHEX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[631]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[544]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[412]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[98]
Chenodiol	DMQ8JIK	Cholelithiasis	DC11	Approved	[632]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[633]

Drug(s) Affected By Glycylpeptide N-tetradecanoyltransferase 2 (NMT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[50]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[98]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[634]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[106]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[6]

Drug(s) Affected By Glutathione S-transferase P (GSTP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[635]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[457]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[636]
Chlorambucil	DMRKE63	Chronic lymphocytic leukaemia	2A82.0	Approved	[636]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[637]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[193]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[35]
Selenium	DM25CGV	N. A.	N. A.	Approved	[44]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[166]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[638]

Drug(s) Affected By Protein S100-A4 (S100A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[207]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[319]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[38]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[639]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[217]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[609]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[227]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]

Drug(s) Affected By Tyrosine-protein kinase Fyn (FYN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[640]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[489]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[641]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[206]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[98]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[615]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[473]

Drug(s) Affected By Bridging integrator 3 (BIN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[121]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[98]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[122]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[6]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[528]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[225]

Drug(s) Affected By Transcription factor AP-2-alpha (TFAP2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[642]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[202]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[643]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[572]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[38]
Paroxetine	DM5PVQE	Anxiety disorder	6B00-6B0Z	Approved	[642]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[107]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[227]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[146]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[146]

Drug(s) Affected By Four and a half LIM domains protein 1 (FHL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[207]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[644]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[504]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[43]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[440]
Isoproterenol	DMK7MEY	Atrioventricular block		Approved	[645]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[109]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[646]

Drug(s) Affected By Cysteine-rich hydrophobic domain-containing protein 2 (CHIC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[123]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[98]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[647]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[133]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[108]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[198]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[61]

Drug(s) Affected By Inositol monophosphatase 2 (IMPA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[207]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[526]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[103]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[412]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[98]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[457]

Drug(s) Affected By Neural cell adhesion molecule L1 (L1CAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[60]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[648]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[38]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[648]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[649]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[457]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[55]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[529]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[265]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[650]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[187]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[651]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[652]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[653]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[654]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[655]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[656]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[657]

Drug(s) Affected By Kynurenine--oxoglutarate transaminase 3 (KYAT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[553]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[122]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[658]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[198]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[199]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[476]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[225]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[470]

Drug(s) Affected By Beta-secretase 2 (BACE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[38]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[345]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[114]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[109]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[457]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[126]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[571]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[122]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[547]

Drug(s) Affected By Histone deacetylase 9 (HDAC9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[225]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[207]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[659]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[480]
Pirfenidone	DM6VZFQ	Idiopathic pulmonary fibrosis	CB03.4	Approved	[659]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[320]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[103]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[481]
Indomethacin	DMSC4A7	Bursitis		Approved	[660]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[661]

Drug(s) Affected By SH3 domain-binding protein 5 (SH3BP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[345]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[662]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[40]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[133]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[108]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[198]
Bardoxolone methyl	DMODA2X	Mixed connective tissue disease	4A43.3	Phase 3	[663]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[543]

Drug(s) Affected By Glutathione S-transferase Mu 4 (GSTM4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[149]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[233]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Bortezomib	DMNO38U	Leukemia		Approved	[43]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[664]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[106]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[546]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[665]

Drug(s) Affected By Ras-related protein Rab-20 (RAB20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[79]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[103]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[511]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[666]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[98]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]

Drug(s) Affected By Tumor protein D52 (TPD52)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[667]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[667]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[50]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[667]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[227]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[668]

Drug(s) Affected By DNA dC->dU-editing enzyme APOBEC-3C (APOBEC3C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[63]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[107]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[439]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[108]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[103]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[98]
Artesunate	DMR27C8	Infection of P. falciparum	1F40	Approved	[669]

Drug(s) Affected By Kazrin (KAZN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[98]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[224]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[106]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[553]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[524]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[6]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[6]

Drug(s) Affected By DNA-binding protein inhibitor ID-4 (ID4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[38]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[480]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[345]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[481]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[402]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[98]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[615]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[224]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[55]

Drug(s) Affected By Centrosomal protein of 57 kDa (CEP57)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[194]
Selenium	DM25CGV	N. A.	N. A.	Approved	[44]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[670]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[439]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[43]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[671]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[411]

Drug(s) Affected By Epithelial membrane protein 2 (EMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[44]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[397]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[672]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[98]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[70]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[673]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[674]

Drug(s) Affected By Dermatan-sulfate epimerase (DSE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[44]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[481]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[457]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[126]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[531]

Drug(s) Affected By Adhesion G-protein coupled receptor G1 (ADGRG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[207]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[38]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[227]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[675]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[676]

Drug(s) Affected By Cyclic GMP-AMP phosphodiesterase SMPDL3A (SMPDL3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[70]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[677]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[126]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[571]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[474]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[628]

Drug(s) Affected By MAPK/MAK/MRK overlapping kinase (MOK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[583]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[473]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[678]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[122]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[6]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[6]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[6]

Drug(s) Affected By High mobility group protein HMG-I/HMG-Y (HMGA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[35]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[534]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[679]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[98]
Methamphetamine	DMPM4SK	Anxiety		Approved	[680]

Drug(s) Affected By Receptor tyrosine-protein kinase erbB-3 (ERBB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[60]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[681]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[38]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[227]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[102]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[562]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[682]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[683]

Drug(s) Affected By Dr1-associated corepressor (DRAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[454]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[109]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[98]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[126]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[6]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[6]

Drug(s) Affected By Latent-transforming growth factor beta-binding protein 2 (LTBP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[345]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[525]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[200]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[106]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[122]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[108]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[6]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[6]

Drug(s) Affected By Terminal nucleotidyltransferase 5A (TENT5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[194]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[631]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[403]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[109]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[98]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[411]

Drug(s) Affected By Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LITAF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[44]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[107]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[124]
Mecamylamine	DMGQFYB	Essential hypertension	BA00	Approved	[684]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[481]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[98]

Drug(s) Affected By DNA repair protein RAD51 homolog 3 (RAD51C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[145]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[569]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[158]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[158]

Drug(s) Affected By Calcium-dependent secretion activator 2 (CADPS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[420]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[479]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[547]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[6]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[668]

Drug(s) Affected By Matrilin-2 (MATN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[93]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[685]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[519]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[206]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[109]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[418]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[106]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[55]

Drug(s) Affected By NADPH--cytochrome P450 reductase (POR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[122]
Tacrolimus	DMZ7XNQ	Graft-versus-host disease	4B24	Approved	[686]
Selenium	DM25CGV	N. A.	N. A.	Approved	[44]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[687]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[512]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]

Drug(s) Affected By Ensconsin (MAP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[207]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[211]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[227]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[417]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[367]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[457]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[126]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[474]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[108]

Drug(s) Affected By Protein artemis (DCLRE1C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[123]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[50]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[107]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[126]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[546]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[688]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[688]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[198]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[40]

Drug(s) Affected By Sorbin and SH3 domain-containing protein 1 (SORBS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[229]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[319]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[100]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[439]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[103]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[200]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[457]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[224]

Drug(s) Affected By Protein mago nashi homolog (MAGOH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[93]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[634]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[546]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[199]
PP-242	DM2348V	Discovery agent	N.A.	Investigative	[689]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[690]

Drug(s) Affected By Urokinase-type plasminogen activator (PLAU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[84]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[79]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[691]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[84]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[38]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[113]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[101]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[692]

Drug(s) Affected By Acylamino-acid-releasing enzyme (APEH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[109]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[98]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[122]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[693]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[108]

Drug(s) Affected By Hematopoietic lineage cell-specific protein (HCLS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[319]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[519]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[512]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[439]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[109]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[104]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[694]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[55]

Drug(s) Affected By S-adenosylhomocysteine hydrolase-like protein 1 (AHCYL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[233]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[108]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[576]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[106]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[133]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[6]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[6]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[6]

Drug(s) Affected By Long-chain fatty acid transport protein 3 (SLC27A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[59]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[695]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[109]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[200]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[98]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[457]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[126]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[122]

Drug(s) Affected By Metallothionein-1E (MT1E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[77]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[230]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[696]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[101]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[697]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[698]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[109]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[699]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[700]

Drug(s) Affected By Arginine vasopressin-induced protein 1 (AVPI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[107]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[481]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[403]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[109]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[98]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[473]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[133]

Drug(s) Affected By Neuroendocrine protein 7B2 (SCG5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[480]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[481]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[109]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[701]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[457]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[430]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[524]

Drug(s) Affected By Carbamoyl-phosphate synthase , mitochondrial (CPS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[70]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[569]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[320]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[206]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[702]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[109]
Flucloxacillin	DMNUWST	Bacterial infection	1A00-1C4Z	Approved	[703]

Drug(s) Affected By Peripheral myelin protein 22 (PMP22)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[70]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[207]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[107]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[417]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[200]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[704]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[457]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[705]

Drug(s) Affected By Kinesin-like protein KIF23 (KIF23)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[455]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[76]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Riboflavin	DM8YMWE	Acne vulgaris	ED80	Approved	[706]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]

Drug(s) Affected By SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related (HMG20B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[707]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[6]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[6]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[198]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[129]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[476]
geraniol	DMS3CBD	Discovery agent	N.A.	Investigative	[708]

Drug(s) Affected By Protein Niban 1 (NIBAN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[44]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[639]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[480]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[422]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[120]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[481]

Drug(s) Affected By LIM and calponin homology domains-containing protein 1 (LIMCH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[44]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[207]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[319]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[38]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[120]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[481]

Drug(s) Affected By Galectin-3 (LGALS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[263]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[580]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[38]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[50]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[107]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[580]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]

Drug(s) Affected By L-dopachrome tautomerase (DCT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[327]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[207]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[430]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[637]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[637]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[709]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[6]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[148]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[710]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[711]

Drug(s) Affected By Epithelial discoidin domain-containing receptor 1 (DDR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[207]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[227]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[345]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[481]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[403]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[125]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[530]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[122]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[524]

Drug(s) Affected By Tissue factor pathway inhibitor 2 (TFPI2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[38]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[63]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[107]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[481]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[109]

Drug(s) Affected By Suppressor of tumorigenicity 7 protein (ST7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[207]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[439]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[98]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[473]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[55]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[122]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[6]

Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[146]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[712]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[193]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[150]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[713]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[714]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[715]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[618]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[716]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[458]

Drug(s) Affected By CTD small phosphatase-like protein (CTDSPL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[98]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[457]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[106]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[717]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[133]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[198]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[44]

Drug(s) Affected By C-X-C motif chemokine 5 (CXCL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[67]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[251]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[38]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[233]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[592]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[115]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[481]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[718]

Drug(s) Affected By Eukaryotic translation initiation factor 5B (EIF5B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[130]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[130]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[411]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[634]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[442]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[129]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[719]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Human Deoxyribonucleic acid (hDNA)	TTUTN1I	NOUNIPROTAC	Binder	[4]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[5]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
A-kinase anchor protein 12 (AKAP12)	OTCVRDDX	AKA12_HUMAN	Drug Response	[6]
Acid ceramidase (ASAH1)	OT1DNGXL	ASAH1_HUMAN	Drug Response	[6]
Actin-binding LIM protein 1 (ABLIM1)	OTHXEK3E	ABLM1_HUMAN	Drug Response	[6]
Activated RNA polymerase II transcriptional coactivator p15 (SUB1)	OTK71JYU	TCP4_HUMAN	Gene/Protein Processing	[7]
Acyl-coenzyme A thioesterase 2, mitochondrial (ACOT2)	OTAKUO27	ACOT2_HUMAN	Drug Response	[6]
Acylamino-acid-releasing enzyme (APEH)	OTX258QE	ACPH_HUMAN	Drug Response	[6]
Adhesion G-protein coupled receptor G1 (ADGRG1)	OTQBB8NT	AGRG1_HUMAN	Drug Response	[6]
Aldehyde dehydrogenase, dimeric NADP-preferring (ALDH3A1)	OTAYZZE6	AL3A1_HUMAN	Drug Response	[8]
Aldehyde oxidase (AOX1)	OT2FZP6H	AOXA_HUMAN	Drug Response	[6]
Alternative prion protein (PRNP)	OTE85L1Q	APRIO_HUMAN	Gene/Protein Processing	[7]

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