Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMHYLQ2)

• Drug Name: Lithium chloride Drug Info
• Synonyms: LITHIUM CHLORIDE; 7447-41-8; Lithiumchloride; Lithium chloride (LiCl); LiCl; chlorure de lithium; Chlorku litu; chlorolithium; Lithiumchlorid; Chlorku litu [Polish]; Luthium chloride; Chlorure de lithium [French]; CCRIS 5924; UNII-G4962QA067; HSDB 4281; EINECS 231-212-3; lithium(1+) ion chloride; NSC 327172; CHEMBL69710; CHEBI:48607; NSC327172; MFCD00011078; G4962QA067; Lithium chloride, 99%, extra pure; ClLi; Lithium chloride, 99+%, ACS reagent; Lithium chloride, 99%, for molecular biology; Lithium chloride, 99%, for analysis, anhyd

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 433294
  ChEBI ID: CHEMBL69710
  CAS Number: CAS 7447-41-8
  TTD Drug ID: DMHYLQ2

Molecule-Related Drug Atlas

Drug(s) Targeting Glycogen synthase kinase-3 alpha (GSK-3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[5]
LY2090314	DMTBFE4	Acute myeloid leukaemia	2A60	Phase 2	[6]
Lithium	DMZ3OU6	Bipolar disorder	6A60	Phase 2	[7]
KENPAULLONE	DMAGVXW	Discovery agent	N.A.	Patented	[6]
CHIR-99021	DMB8MNU	Allergic inflammation	4A80-4A85	Patented	[6]
TDZD-8	DMG6Q45	Malignant glioma	2A00.0	Patented	[6]
AR-A014418	DMUPN01	Ovarian cancer	2C73	Patented	[6]
PMID27828716-Compound-21	DMO1NAR	N. A.	N. A.	Patented	[6]
Thiadiazolidindione derivative 2	DM5AUL0	N. A.	N. A.	Patented	[6]
PMID27828716-Compound-18	DMNR6KL	N. A.	N. A.	Patented	[6]

Drug(s) Affected By Paired box protein Pax-3 (PAX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[8]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[9]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[10]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[9]
Nilotinib	DM7HXWT	Chronic myelogenous leukaemia	2A20.0	Approved	[9]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[11]
Dabigatran	DMDI6R4	Stroke	8B20	Approved	[9]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[12]
Abacavir	DMMN36E	Human immunodeficiency virus infection	1C62	Approved	[9]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[13]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[14]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[15]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[16]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[18]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[19]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[20]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[21]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[22]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[23]

Drug(s) Affected By Homeobox protein SIX1 (SIX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[10]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[26]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[27]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[28]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[29]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[30]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[31]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[32]

Drug(s) Affected By Cell division cycle 7-related protein kinase (CDC7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[33]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[35]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[36]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[38]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[39]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[40]

Drug(s) Affected By Cdc42 effector protein 2 (CDC42EP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[44]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[45]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[46]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[47]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[49]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[30]

Drug(s) Affected By Dihydroxyacetone phosphate acyltransferase (GNPAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[51]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[52]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[27]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[46]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[41]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[53]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[31]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[54]

Drug(s) Affected By Intermediate conductance calcium-activated potassium channel protein 4 (KCNN4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[55]
Chlorzoxazone	DMCYVDT	Acute pain	MG31	Approved	[56]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[27]
Charybdotoxin	DMKN345	Scorpion envenoming syndrome	8D43	Approved	[57]
Clotrimazole	DMMFCIH	Cutaneous candidiasis	1F23.14	Approved	[56]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[58]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[41]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[60]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[61]

Drug(s) Affected By Heat shock 70 kDa protein 12A (HSPA12A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[64]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[51]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[44]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[65]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[66]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[67]

Drug(s) Affected By Phospholipid phosphatase 2 (PLPP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[68]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[70]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[71]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[72]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[73]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[29]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[74]

Drug(s) Affected By Microphthalmia-associated transcription factor (MITF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[75]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[76]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[77]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[78]
Vemurafenib	DM62UG5	Melanoma	2C30	Approved	[79]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[51]

Drug(s) Affected By Kelch repeat and BTB domain-containing protein 11 (KBTBD11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[82]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[10]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[83]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[27]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[66]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[41]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[84]

Drug(s) Affected By CUGBP Elav-like family member 2 (CELF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[85]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[86]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[50]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[88]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[45]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[89]

Drug(s) Affected By Adenomatous polyposis coli protein 2 (APC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[90]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[91]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[92]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[31]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[93]
UNC0379	DMD1E4J	Hepatocellular carcinoma	2C12.02	Preclinical	[94]
AHPN	DM8G6O4	Discovery agent	N.A.	Investigative	[95]

Drug(s) Affected By Histone-lysine N-methyltransferase NSD2 (NSD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[54]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[10]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[96]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[97]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[38]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[46]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]

Drug(s) Affected By Tropomyosin alpha-1 chain (TPM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[33]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[99]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[68]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[100]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[51]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[45]
Bortezomib	DMNO38U	Leukemia		Approved	[101]

Drug(s) Affected By Alkaline phosphatase, germ cell type (ALPG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[102]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[103]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[104]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[105]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[102]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[106]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[107]
Hydroxyestradiol	DMJXQME	N. A.	N. A.	Investigative	[104]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[108]

Drug(s) Affected By Hyaluronan and proteoglycan link protein 1 (HAPLN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[10]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[60]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[109]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[10]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[110]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[74]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[10]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[111]

Drug(s) Affected By Laminin subunit gamma-1 (LAMC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[112]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[50]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[113]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[114]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[51]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[27]
Indomethacin	DMSC4A7	Bursitis		Approved	[115]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[41]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[116]

Drug(s) Affected By Metallothionein-1G (MT1G)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[117]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[118]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[119]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[120]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[64]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[122]

Drug(s) Affected By Plastin-2 (LCP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[123]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[124]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Hydroxyflutamide	DMGIZF5	Prostate cancer	2C82.0	Approved	[125]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[126]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[44]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[27]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]

Drug(s) Affected By Troponin T, slow skeletal muscle (TNNT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[127]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[128]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[27]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[129]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[28]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[130]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[129]

Drug(s) Affected By Beta-1,4-galactosyltransferase 1 (B4GALT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[131]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[26]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[51]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[45]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[132]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[132]
Estriol	DMOEM2I	Hormone deficiency	5A61.1	Approved	[132]

Drug(s) Affected By CD44 antigen (CD44)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[133]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[134]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[41]
Selenium	DM25CGV	N. A.	N. A.	Approved	[135]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[136]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[137]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[112]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[138]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[10]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[139]

Drug(s) Affected By Cadherin-2 (CDH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[140]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[141]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[142]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[10]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[143]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[144]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[145]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[146]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[147]

Drug(s) Affected By Guanine nucleotide-binding protein G(z) subunit alpha (GNAZ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[148]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[46]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[41]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[74]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[30]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[17]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[37]

Drug(s) Affected By B-cell lymphoma 3 protein (BCL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[149]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[150]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[151]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[64]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[152]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[152]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[152]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[88]

Drug(s) Affected By Receptor tyrosine-protein kinase erbB-3 (ERBB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[153]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[154]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[10]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[69]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[11]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[129]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[155]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[156]

Drug(s) Affected By Pentraxin-related protein PTX3 (PTX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[157]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[158]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[26]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[38]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[159]
Bortezomib	DMNO38U	Leukemia		Approved	[160]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[66]

Drug(s) Affected By 5-hydroxytryptamine receptor 2A (HTR2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[161]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[162]
Paliperidone	DM7NPJS	Psychotic disorder	6A20-6A25	Approved	[163]
Haloperidol	DM96SE0	Delirium		Approved	[163]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[27]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[164]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[165]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[67]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[166]

Drug(s) Affected By Protein S100-A3 (S100A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[85]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[167]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[51]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[44]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[27]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[46]

Drug(s) Affected By Amiloride-sensitive sodium channel subunit alpha (SCNN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[168]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[169]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[10]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[170]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[69]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[64]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[171]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]

Drug(s) Affected By Alpha-synuclein (SNCA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[96]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[172]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[51]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[83]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[27]
Bortezomib	DMNO38U	Leukemia		Approved	[173]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[174]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[65]

Drug(s) Affected By Melanocyte protein PMEL (PMEL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[175]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[50]
Vemurafenib	DM62UG5	Melanoma	2C30	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[65]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[176]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[84]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[128]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 2A (CDKN2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[177]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[33]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[178]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[179]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[22]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[181]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[182]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[183]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[184]

Drug(s) Affected By Cyclin-dependent kinase 4 inhibitor B (CDKN2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[177]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[185]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[140]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[178]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[186]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[187]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[97]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[97]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]

Drug(s) Affected By Neurogenic locus notch homolog protein 1 (NOTCH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[188]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[189]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[190]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[68]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[191]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[192]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[27]
Mebendazole	DMO14SG	Ascariasis	1F62	Approved	[193]

Drug(s) Affected By Adhesion G protein-coupled receptor E5 (ADGRE5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[41]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[194]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[195]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[50]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[196]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[26]

Drug(s) Affected By Paxillin (PXN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[198]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[199]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[200]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[87]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[2]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[51]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[201]
Terbinafine	DMI6HUW	Fungal infection	1F29-1F2F	Approved	[202]

Drug(s) Affected By CCAAT/enhancer-binding protein delta (CEBPD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[85]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[10]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[203]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[204]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[97]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[97]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]

Drug(s) Affected By Annexin A11 (ANXA11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[51]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[207]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[53]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[29]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[105]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[208]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[209]

Drug(s) Affected By Mitogen-activated protein kinase 10 (MAPK10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[10]
Sorbitol	DMAN0DE	Constipation	DD91.1	Approved	[210]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[211]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[207]
Dicumarol	DMFQCB1	Bleeding disorder	GA20-GA21	Approved	[210]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[88]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[44]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[212]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[210]

Drug(s) Affected By Troponin C, slow skeletal and cardiac muscles (TNNC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[213]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[51]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[166]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[74]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[30]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[128]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[31]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[93]

Drug(s) Affected By Cyclin-A1 (CCNA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[214]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[215]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[214]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[216]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[217]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[215]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[12]
Atropine	DMEN6X7	Organophosphate poisoning	NE6Z	Approved	[218]

Drug(s) Affected By Helix-loop-helix protein 1 (NHLH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[29]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[31]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[85]

Drug(s) Affected By Proteasome activator complex subunit 1 (PSME1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[123]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[51]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[46]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[65]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[65]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[47]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]

Drug(s) Affected By 3',5'-cyclic-AMP phosphodiesterase 4B (PDE4B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[214]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[216]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[26]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[44]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[83]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[220]

Drug(s) Affected By Kinesin heavy chain isoform 5A (KIF5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[91]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[221]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[222]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[30]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[31]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[85]

Drug(s) Affected By Protein AF1q (MLLT11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[223]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[167]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[123]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[224]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[44]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[27]
Bortezomib	DMNO38U	Leukemia		Approved	[101]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[225]

Drug(s) Affected By DNA topoisomerase 3-alpha (TOP3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[226]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[68]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[114]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[27]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[226]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[226]
Adenine	DMZLHKJ	Malnutrition	5B50-5B71	Approved	[226]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[31]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[227]

Drug(s) Affected By Protein disulfide-isomerase A5 (PDIA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[10]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[152]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[152]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[152]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[152]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[51]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[152]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[152]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[152]

Drug(s) Affected By Platelet-derived growth factor receptor-like protein (PDGFRL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[69]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[12]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[44]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[27]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[45]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[28]

Drug(s) Affected By Ecto-NOX disulfide-thiol exchanger 2 (ENOX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[46]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[29]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[228]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[229]
Phenoxodiol	DMBUJVX	Ovarian cancer	2C73	Phase 1/2	[229]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[230]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[85]

Drug(s) Affected By Reticulon-1 (RTN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[50]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[10]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[51]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[231]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[10]

Drug(s) Affected By Tumor protein D53 (TPD52L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[35]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[50]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[10]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[97]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[152]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[97]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[152]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[152]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[152]

Drug(s) Affected By Collagen alpha-1(XIII) chain (COL13A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[148]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[27]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[45]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[232]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[65]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[233]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]

Drug(s) Affected By RNA-binding protein MEX3B (MEX3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[27]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[234]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[46]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[89]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[235]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[84]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]

Drug(s) Affected By Probable RNA-binding protein 23 (RBM23)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[96]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[236]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[30]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[237]

Drug(s) Affected By Dynein regulatory complex protein 11 (IQCA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[10]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[238]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[97]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[128]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[31]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[93]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[239]

Drug(s) Affected By Protein FAM90A1 (FAM90A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[234]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[240]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[31]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[241]

Drug(s) Affected By E3 ubiquitin-protein ligase MIB1 (MIB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[123]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[242]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[191]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[46]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[53]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[111]

Drug(s) Affected By GRAM domain-containing protein 2A (GRAMD2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[243]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[128]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[31]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[244]

Drug(s) Affected By cTAGE family member 4 (CTAGE4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[2]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[105]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[240]

Drug(s) Affected By MARVEL domain-containing protein 2 (MARVELD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[64]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[12]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[74]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[240]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[31]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[93]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[54]

Drug(s) Affected By Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 (GBGT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[123]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[176]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[29]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[128]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[245]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[246]

Drug(s) Affected By Myc target protein 1 (MYCT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[207]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[74]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[111]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[31]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[32]

Drug(s) Affected By Formylglycine-generating enzyme (SUMF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[247]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[123]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[64]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[51]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[27]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[46]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[41]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[84]

Drug(s) Affected By Probable aminopeptidase NPEPL1 (NPEPL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[51]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[27]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[17]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[31]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[248]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[45]

Drug(s) Affected By sn-1-specific diacylglycerol lipase ABHD11 (ABHD11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[26]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[51]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[47]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[249]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[105]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[47]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[250]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[93]

Drug(s) Affected By Protein phosphatase 1 regulatory subunit 14C (PPP1R14C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[97]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[97]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[114]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[27]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[235]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[251]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[74]

Drug(s) Affected By Jun dimerization protein 2 (JDP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[41]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[10]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[62]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[83]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[46]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[89]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[235]

Drug(s) Affected By FXYD domain-containing ion transport regulator 5 (FXYD5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[252]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[123]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[253]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[10]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[252]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[46]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[65]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[65]

Drug(s) Affected By Corrinoid adenosyltransferase MMAB (MMAB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[247]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[64]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[236]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[46]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[235]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[254]

Drug(s) Affected By GRAM domain-containing protein 2B (GRAMD2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[255]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[27]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[235]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[37]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[128]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[30]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[128]

Drug(s) Affected By Sperm-associated antigen 5 (SPAG5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[41]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[256]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[35]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[123]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[97]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[97]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[51]

Drug(s) Affected By Tribbles homolog 3 (TRIB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[117]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[252]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[148]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[257]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[119]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[258]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[257]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[216]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[259]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[87]

Drug(s) Affected By Centrosome-associated protein CEP250 (CEP250)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[114]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[46]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[93]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[54]

Drug(s) Affected By Tripartite motif-containing protein 6 (TRIM6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[148]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[10]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[27]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[159]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[67]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[110]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[10]

Drug(s) Affected By Tumor protein 63 (TP63)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[85]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[260]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[261]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[262]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[243]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[234]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[46]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[263]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[66]

Drug(s) Affected By Protein ILRUN (ILRUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[264]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[11]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[46]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[264]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[128]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[264]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[265]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[85]

Drug(s) Affected By Retinoid-inducible serine carboxypeptidase (SCPEP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[120]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[68]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[80]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[172]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[51]
Bortezomib	DMNO38U	Leukemia		Approved	[101]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]

Drug(s) Affected By CDC42 small effector protein 1 (CDC42SE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[28]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[46]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[53]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[126]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[31]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[266]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[32]

Drug(s) Affected By DNA-directed RNA polymerase III subunit RPC2 (POLR3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[123]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[27]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[46]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[65]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[65]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[53]

Drug(s) Affected By Telomeric repeat-binding factor 2-interacting protein 1 (TERF2IP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[267]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[53]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[30]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[17]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[111]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[268]

Drug(s) Affected By Abl interactor 2 (ABI2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[123]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[124]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[51]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[46]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[269]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[270]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[93]

Drug(s) Affected By Formin-2 (FMN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[234]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[66]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[67]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[10]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[31]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[85]

Drug(s) Affected By Sedoheptulokinase (SHPK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[41]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[211]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[46]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[270]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[85]

Drug(s) Affected By Purine-rich element-binding protein gamma (PURG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[10]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[214]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[10]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[31]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[93]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[32]

Drug(s) Affected By Protein phosphatase 1H (PPM1H)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[69]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[44]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[39]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[234]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[46]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[130]

Drug(s) Affected By Apoptosis-associated speck-like protein containing a CARD (PYCARD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[133]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[123]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[10]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[271]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[272]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[273]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[88]

Drug(s) Affected By Zinc finger protein PLAGL1 (PLAGL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[19]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Riboflavin	DM8YMWE	Acne vulgaris	ED80	Approved	[274]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[275]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[276]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[128]

Drug(s) Affected By Melanoma-associated antigen D2 (MAGED2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[114]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[51]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[46]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[66]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[17]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[31]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[93]

Drug(s) Affected By Potassium channel subfamily K member 6 (KCNK6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[124]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[87]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[114]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[84]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[277]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[74]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[10]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[270]

Drug(s) Affected By Pleckstrin homology domain-containing family A member 6 (PLEKHA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[41]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[97]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[97]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[46]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[66]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[41]

Drug(s) Affected By Oligoribonuclease, mitochondrial (REXO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[123]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[51]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[46]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[41]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[53]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[29]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[31]

Drug(s) Affected By Ankyrin repeat and SOCS box protein 1 (ASB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[278]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[33]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[45]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[46]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[17]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[265]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[45]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[32]

Drug(s) Affected By Sulfide:quinone oxidoreductase, mitochondrial (SQOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[41]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[123]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[10]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[51]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[44]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[45]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[46]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[279]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[280]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[281]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[16]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[282]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[283]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[284]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[285]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[286]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[287]

Drug(s) Affected By RNA-binding protein Musashi homolog 1 (MSI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[112]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[288]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[66]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[289]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[112]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[290]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[291]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[31]

Drug(s) Affected By Adhesion G protein-coupled receptor B3 (ADGRB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[114]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[128]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[110]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[292]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[31]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[85]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[32]

Drug(s) Affected By Frizzled-6 (FZD6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[114]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[293]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[40]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[128]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[40]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[30]

Drug(s) Affected By Low-density lipoprotein receptor-related protein 6 (LRP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[118]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[123]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[294]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[118]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[128]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[295]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[30]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[111]

Drug(s) Affected By G2/mitotic-specific cyclin-B2 (CCNB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[177]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[279]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[41]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[256]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[35]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[296]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[297]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[298]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[97]

Drug(s) Affected By GTP-binding protein Di-Ras3 (DIRAS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[50]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[203]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[299]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[27]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[235]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[300]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[128]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[111]

Drug(s) Affected By TBC1 domain family member 8 (TBC1D8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[41]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[10]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[97]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[97]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[10]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[44]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[46]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[66]

Drug(s) Affected By Zinc finger protein SNAI1 (SNAI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[153]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[301]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[136]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[302]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[148]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[303]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[304]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[64]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[305]
Sanguinarine	DMDINFS	Dental plaque	DA08.4	Approved	[306]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[307]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[308]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[309]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[185]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[214]
Selenium	DM25CGV	N. A.	N. A.	Approved	[310]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[311]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[312]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[313]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[198]

Drug(s) Affected By Osteocalcin (BGLAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[314]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[315]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[316]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[317]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[318]
Pamidronate	DMB4AVP	Bone Paget disease		Approved	[319]
Falecalcitrol	DMBI9ZJ	Hyperparathyroidism	5A51	Approved	[320]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[321]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[243]

Drug(s) Affected By Alkaline phosphatase, placental type (ALPP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lidocaine	DML4ZOT	Anaesthesia	9A78.6	Approved	[161]
Paricalcitol	DMYBV3G	Hyperparathyroidism	5A51	Approved	[161]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[148]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[322]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[323]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Isoproterenol	DMK7MEY	Atrioventricular block		Approved	[324]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[103]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[325]

Drug(s) Affected By DNA excision repair protein ERCC-1 (ERCC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[10]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[326]
Pemetrexed	DMMX2E6	Central nervous system lymphoma	2B33.5	Approved	[327]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[39]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[46]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[328]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[329]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[330]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[331]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[332]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[333]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[334]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[335]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[336]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[337]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[335]

Drug(s) Affected By Amino acid transporter heavy chain SLC3A2 (SLC3A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[283]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[35]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[338]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[257]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[119]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[257]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[87]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[152]

Drug(s) Affected By Matrilysin (MMP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[19]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[339]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[196]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[69]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[253]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[340]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[341]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[342]

Drug(s) Affected By Histone H2A type 1 (H2AC11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[343]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[50]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[344]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[345]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[97]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[26]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[28]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[46]

Drug(s) Affected By Cadherin-1 (CDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[278]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[301]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[346]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[347]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[348]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[349]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[350]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[10]

Drug(s) Affected By Histone H1.2 (H1-2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[247]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[35]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[123]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[50]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[152]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[152]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[114]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[26]

Drug(s) Affected By Cysteine-rich secretory protein 2 (CRISP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[351]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[67]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[352]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[31]
Calphostin C	DM9X2D0	N. A.	N. A.	Terminated	[353]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-4 (ATF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[308]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[354]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[140]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[283]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[355]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[356]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[357]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[358]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[359]

Drug(s) Affected By Threonine--tRNA ligase 1, cytoplasmic (TARS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[360]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[264]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[123]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[10]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[87]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[64]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[152]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[152]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]

Drug(s) Affected By M-phase inducer phosphatase 3 (CDC25C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[177]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[140]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[19]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[35]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[123]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[119]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[361]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[362]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[97]

Drug(s) Affected By Transmembrane 4 L6 family member 1 (TM4SF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[85]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[82]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[96]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[97]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[80]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[64]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[363]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[51]

Drug(s) Affected By Sodium-dependent serotonin transporter (SLC6A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paroxetine	DM5PVQE	Anxiety disorder	6B00-6B0Z	Approved	[364]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[365]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[41]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[366]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[367]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[368]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Aripiprazole	DM3NUMH	Bipolar I disorder		Approved	[369]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[367]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]

Drug(s) Affected By DNA replication licensing factor MCM4 (MCM4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[177]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[140]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[370]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[22]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[35]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[96]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[97]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[97]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[363]

Drug(s) Affected By DNA replication licensing factor MCM5 (MCM5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[177]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[371]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[35]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[297]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[203]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[97]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[97]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]

Drug(s) Affected By Catenin beta-1 (CTNNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[372]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[140]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[373]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[374]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[375]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[376]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[377]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[378]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[146]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[379]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[380]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[381]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[382]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[280]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[383]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[118]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[282]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[178]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[384]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[226]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[385]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[386]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[178]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[387]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[388]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[389]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[390]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[391]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[392]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[393]

Drug(s) Affected By Retinaldehyde dehydrogenase 3 (ALDH1A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[161]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[394]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[10]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[203]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[87]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[97]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[97]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[152]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[152]

Drug(s) Affected By Phosphatidylinositol transfer protein beta isoform (PITPNB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[112]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[51]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[360]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[395]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[46]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[84]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]

Drug(s) Affected By Centromere protein F (CENPF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[41]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[256]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[35]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[123]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[97]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[97]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[64]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[396]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]

Drug(s) Affected By DNA replication licensing factor MCM2 (MCM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[343]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[22]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[35]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[36]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[97]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[97]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[121]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[51]

Drug(s) Affected By Dual specificity protein kinase CLK2 (CLK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[238]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[200]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[46]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[397]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[31]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[54]
T83193	DMHO29Y	Discovery agent	N.A.	Patented	[398]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[399]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1C (CDKN1C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[41]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[370]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[400]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[400]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[216]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[114]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[101]

Drug(s) Affected By Sodium/myo-inositol cotransporter (SLC5A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[247]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[338]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[216]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[299]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[44]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[45]

Drug(s) Affected By Calcipressin-1 (RCAN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[401]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[10]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[97]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[97]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[402]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[65]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[65]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[401]

Drug(s) Affected By GTP-binding protein RAD (RRAD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[216]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[172]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[26]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[403]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[27]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[234]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[46]

Drug(s) Affected By ATP synthase subunit e, mitochondrial (ATP5ME)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[33]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[404]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[211]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[51]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[46]
Indomethacin	DMSC4A7	Bursitis		Approved	[405]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[406]

Drug(s) Affected By Rho-related GTP-binding protein RhoE (RND3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[117]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[256]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[50]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[10]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[407]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[152]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[152]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[114]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]

Drug(s) Affected By ADP-ribosylation factor 6 (ARF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[112]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[408]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[51]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[236]
Bortezomib	DMNO38U	Leukemia		Approved	[101]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[409]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[84]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]

Drug(s) Affected By Histone H4 (H4C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[343]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[118]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[283]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[150]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[35]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[123]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[410]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[124]

Drug(s) Affected By Calcineurin subunit B type 1 (PPP3R1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[51]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[28]
Bortezomib	DMNO38U	Leukemia		Approved	[101]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[46]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[254]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[161]
Sirolimus	DMGW1ID	Advanced cancer	2A00-2F9Z	Approved	[161]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[161]

Drug(s) Affected By 4-aminobutyrate aminotransferase, mitochondrial (ABAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[10]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[80]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[64]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[51]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[252]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[45]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[103]

Drug(s) Affected By POU domain, class 5, transcription factor 1 (POU5F1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[41]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[136]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[411]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[168]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[10]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[139]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[412]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[413]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[414]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[415]

Drug(s) Affected By DNA-binding protein inhibitor ID-3 (ID3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[416]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[134]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[41]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[345]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[226]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[198]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[35]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[417]

Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[133]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[418]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[419]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[420]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[421]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[422]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[112]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[423]

Drug(s) Affected By Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[117]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[371]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[16]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[424]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[425]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[426]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[427]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[215]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[119]

Drug(s) Affected By Sodium channel protein type 5 subunit alpha (SCN5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Disopyramide	DM5SYZP	Long QT syndrome	BC65.0	Approved	[161]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[428]
Flecainide	DMSQDLE	Tachyarrhythmias	BC71	Approved	[429]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[430]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[431]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[432]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[433]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[434]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Retigabine	DMGNYIH	Behcet disease	4A62	Approved	[435]

Drug(s) Affected By Cyclin-G2 (CCNG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[134]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[257]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[10]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[134]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[96]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[80]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[152]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[152]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]

Drug(s) Affected By Rho GTPase-activating protein 29 (ARHGAP29)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[41]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[370]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[54]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[141]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[64]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[114]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[51]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[436]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[46]

Drug(s) Affected By Protein Largen (PRR16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[10]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[203]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[97]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[97]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[436]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[437]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[67]

Drug(s) Affected By E3 ubiquitin-protein ligase RNF144B (RNF144B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[141]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[123]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[10]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[64]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[114]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[44]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[234]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[66]
Indomethacin	DMSC4A7	Bursitis		Approved	[405]

Drug(s) Affected By Sodium-dependent phosphate transporter 1 (SLC20A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Phosphate	DMUXQG7	Constipation	DD91.1	Approved	[438]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[41]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[338]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[64]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[439]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[38]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[27]

Drug(s) Affected By Protein naked cuticle homolog 1 (NKD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[371]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[10]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[64]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[440]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[46]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[371]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[441]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[37]

Drug(s) Affected By PDZ and LIM domain protein 5 (PDLIM5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[247]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[96]
Haloperidol	DM96SE0	Delirium		Approved	[360]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[64]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[51]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[12]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[360]

Drug(s) Affected By Secreted frizzled-related protein 2 (SFRP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[10]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[124]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[45]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[442]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[67]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[443]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[110]

Drug(s) Affected By Cell division control protein 6 homolog (CDC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[177]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[226]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[370]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[77]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[35]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[112]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[444]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[97]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[97]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]

Drug(s) Affected By Histone H2B type 1-L (H2BC13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[46]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[89]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[41]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[254]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[30]
Berberine	DMC5Q8X	N. A.	N. A.	Phase 4	[445]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[270]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[266]

Drug(s) Affected By Homeobox protein NANOG (NANOG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[446]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[136]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[411]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[168]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[10]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[139]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[412]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[413]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[447]

Drug(s) Affected By Popeye domain-containing protein 3 (POPDC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[123]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[10]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[27]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[37]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[29]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[448]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[128]

Drug(s) Affected By Large ribosomal subunit protein uL29m (MRPL47)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[51]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[449]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[30]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[266]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[450]

Drug(s) Affected By Frizzled-3 (FZD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[150]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[10]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[451]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[27]
Adenosine	DMM2NSK	Paroxysmal supraventricular tachycardia	BC81.Z	Approved	[452]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[46]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[40]

Drug(s) Affected By Cysteine and histidine-rich domain-containing protein 1 (CHORDC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Haloperidol	DM96SE0	Delirium		Approved	[360]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[64]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[51]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[360]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[27]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[46]

Drug(s) Affected By Ras-related protein Rab-23 (RAB23)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[123]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[345]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[97]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[97]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[101]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[65]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[89]

Drug(s) Affected By Frizzled-4 (FZD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[148]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[64]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[293]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[27]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[45]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[46]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[40]

Drug(s) Affected By SH3 and multiple ankyrin repeat domains protein 2 (SHANK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[41]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[367]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[367]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[367]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[234]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[46]

Drug(s) Affected By Axin-2 (AXIN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[10]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[453]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[293]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[440]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[27]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[454]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[46]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[455]

Drug(s) Affected By Hepatoma-derived growth factor-related protein 3 (HDGFL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[251]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[105]
Capecitabine	DMTS85L	Adenocarcinoma	2D40	Approved	[456]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[128]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[270]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[266]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[32]

Drug(s) Affected By Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[133]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[41]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[123]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[96]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[457]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[80]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[458]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[459]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glycogen synthase kinase-3 alpha (GSK-3A)	TTRZQE3	GSK3A_HUMAN	Inhibitor	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
3',5'-cyclic-AMP phosphodiesterase 4B (PDE4B)	OTOA8WU2	PDE4B_HUMAN	Gene/Protein Processing	[2]
4-aminobutyrate aminotransferase, mitochondrial (ABAT)	OTXAGR7J	GABT_HUMAN	Gene/Protein Processing	[3]
5-hydroxytryptamine receptor 2A (HTR2A)	OTWXJX0M	5HT2A_HUMAN	Gene/Protein Processing	[2]
Abl interactor 2 (ABI2)	OT8GIIS5	ABI2_HUMAN	Gene/Protein Processing	[2]
Adenomatous polyposis coli protein 2 (APC2)	OTRH91CX	APCL_HUMAN	Gene/Protein Processing	[2]
Adhesion G protein-coupled receptor B3 (ADGRB3)	OT1EWGRW	AGRB3_HUMAN	Gene/Protein Processing	[3]
Adhesion G protein-coupled receptor E5 (ADGRE5)	OTTSB84Q	AGRE5_HUMAN	Gene/Protein Processing	[2]
ADP-ribosylation factor 6 (ARF6)	OTVV7KJO	ARF6_HUMAN	Gene/Protein Processing	[3]
Alkaline phosphatase, germ cell type (ALPG)	OTCIM29R	PPBN_HUMAN	Gene/Protein Processing	[2]
Alkaline phosphatase, placental type (ALPP)	OTZU4G9W	PPB1_HUMAN	Gene/Protein Processing	[4]

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