Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMTAJQE)

• Drug Name: Amphotericin B Drug Info
• Synonyms: ABLC; Abelcet; Abelecet; Ambisome; Amphocin; Amphomoronal; Amphotec; Amphotericin; Amphotericinum; Amphotherizin; Amphozone; Fungilin; Fungisome; Fungisone; Fungizone; Halizon; SinuNase; Amfotericina B; Amophotericin B; Amphortericin B; Amphotericin B Cholesterol Dispersion; Amphotericin B Colloidal Dispersion; Amphotericin B liposomal; Amphotericin BETA; Amphotericine B; Amphotericinum B; Amphotherizin [German]; Liposomal Amphotericin B; NCI527017; NS 718; AMPH-B; Abelcet (TN); AmBisome (TN); Amfotericina B [INN-Spanish]; Ampho-Moronal; Amphocil (TN); Amphotec (TN); Amphotericin-B; Amphotericine B [INN-French]; Amphotericinum B [INN-Latin]; Fungilin (TN); Fungisome (TN); Fungizone (TN); LNS-AmB; Mysteclin-F; NKTR-024; Amphotericin B [USAN:INN:JAN]; Amphotericin B, Lipid-based; Amphotericin B, Streptomyces sp.; Amphotericin B (JP15/USP/INN)

Indication

Disease Entry	ICD 11	Status	REF
Acne vulgaris	ED80	Approved	[1]
Actinomycosis		Approved	[1]
Acute gonococcal cervicitis		Approved	[1]
Aspergillosis	1F20	Approved	[1]
Blastomycosis	1F22	Approved	[1]
Bronchitis	CA20	Approved	[1]
Brucellosis		Approved	[1]
Candidiasis	1F23	Approved	[1]
Coccidioidomycosis	1F25	Approved	[1]
Cryptococcal meningitis		Approved	[1]
Cryptococcosis		Approved	[1]
Cutaneous candidiasis	1F23.14	Approved	[1]
Disseminated sporotrichosis		Approved	[1]
Fungal infection	1F29-1F2F	Approved	[2]
Histoplasmosis		Approved	[1]
Invasive candidiasis	1F23	Approved	[1]
Leishmaniasis	1F54	Approved	[1]
Lymphogranuloma venereum		Approved	[1]
Mycotic endocarditis		Approved	[1]
Oral candidiasis	1F23.0	Approved	[1]
Ornithosis		Approved	[1]
Pneumonia	CA40	Approved	[1]
Q fever		Approved	[1]
Relapsing fever		Approved	[1]
Rickettsialpox		Approved	[1]
Rocky mountain spotted fever		Approved	[1]
Syphilis		Approved	[1]
Trachoma		Approved	[1]
Typhus		Approved	[1]
Urinary tract infection	GC08	Approved	[1]
Yaws		Approved	[1]
Candidemia	1F23.3Y	Investigative	[1]
Esophageal candidiasis		Investigative	[1]
Mycoses	1F2Z	Investigative	[3]
Pelvic inflammatory disease	GA05	Investigative	[1]
Sinusitis	CA0A.Z	Investigative	[1]

• Therapeutic Class: Antifungal Agents
• Cross-matching ID:
  PubChem CID: 5280965
  CAS Number: CAS 1397-89-3
  TTD Drug ID: DMTAJQE
  VARIDT Drug ID: DR01468

Molecule-Related Drug Atlas

Drug(s) Targeting Fungal Cell membrane ergosterol (Fung CME)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nystatin	DM63QS9	Cutaneous candidiasis	1F23.14	Approved	[7]
Candicidin	DMNZSC1	Bacterial infection	1A00-1C4Z	Approved	[8]

Drug(s) Transported By P-glycoprotein 1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[9]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[10]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[11]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[12]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[11]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[11]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[13]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[11]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[14]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[15]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[16]
Fructose	DM43AN2	Vomiting	MD90	Approved	[17]
Ketoprofen	DMRKXPT	Bursitis		Approved	[17]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[18]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[19]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[20]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[21]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[22]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[23]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[24]

Drug(s) Affected By Interferon gamma (IFNG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[24]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[25]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[26]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[27]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[28]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[31]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[32]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[33]

Drug(s) Affected By RNA-binding protein 47 (RBM47)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[36]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[40]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[41]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[42]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[43]

Drug(s) Affected By Neural cell adhesion molecule L1-like protein (CHL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[43]
Paroxetine	DM5PVQE	Anxiety disorder	6B00-6B0Z	Approved	[45]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[47]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[48]

Drug(s) Affected By Disks large-associated protein 1 (DLGAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[50]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[47]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[48]

Drug(s) Affected By Receptor-type tyrosine-protein phosphatase T (PTPRT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[52]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[53]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]

Drug(s) Affected By Proepiregulin (EREG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[54]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[55]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[34]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[55]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[55]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[56]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[55]

Drug(s) Affected By Transcription factor EC (TFEC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[61]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[62]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[62]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[62]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[62]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[50]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[63]

Drug(s) Affected By Calsequestrin-2 (CASQ2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[65]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[66]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[41]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[67]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[53]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[68]

Drug(s) Affected By Long-chain fatty acid transport protein 2 (SLC27A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[27]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[70]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[36]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[71]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[73]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[74]

Drug(s) Affected By Serine/threonine-protein kinase DCLK1 (DCLK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[75]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[40]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[76]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[77]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[78]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[79]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[80]

Drug(s) Affected By Low-density lipoprotein receptor class A domain-containing protein 4 (LDLRAD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[47]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[83]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[77]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[79]

Drug(s) Affected By Kynurenine 3-monooxygenase (KMO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[49]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[85]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[76]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[42]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[86]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[87]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[50]

Drug(s) Affected By Metabotropic glutamate receptor 6 (GRM6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[41]

Drug(s) Affected By Transmembrane protease serine 2 (TMPRSS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[88]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[88]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[34]
Selenium	DM25CGV	N. A.	N. A.	Approved	[81]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[88]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[88]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[88]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[88]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[88]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[88]

Drug(s) Affected By Monocarboxylate transporter 7 (SLC16A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[89]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[70]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[90]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[91]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[92]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[74]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]

Drug(s) Affected By TOX high mobility group box family member 3 (TOX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[93]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[93]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[94]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[80]

Drug(s) Affected By Insulin-induced gene 1 protein (INSIG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[97]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[85]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[98]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[99]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[36]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[98]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[100]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[93]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[74]

Drug(s) Affected By Glutamate receptor ionotropic, delta-2 (GRID2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[101]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[102]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[41]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[53]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]

Drug(s) Affected By Carbonic anhydrase 12 (CA12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetazolamide	DM1AF5U	Absence epilepsy		Approved	[103]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[104]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[34]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[85]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[104]
Topiramate	DM82Z30	Alcohol dependence	6C40.2	Approved	[105]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[106]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]

Drug(s) Affected By Protein sprouty homolog 1 (SPRY1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[34]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[74]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[40]

Drug(s) Affected By Germinal-center associated nuclear protein (MCM3AP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[107]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[108]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[109]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[42]
Fenretinide	DMRD5SP	Macular degeneration	9B78.3	Phase 3	[110]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[81]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[109]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[111]

Drug(s) Affected By Periplakin (PPL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[37]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[93]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[57]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[112]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[113]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[42]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[114]

Drug(s) Affected By GDNF family receptor alpha-3 (GFRA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[100]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[115]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[116]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[48]

Drug(s) Affected By Galanin receptor type 3 (GALR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[81]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
QUERCITRIN	DM1DH96	Discovery agent	N.A.	Investigative	[117]

Drug(s) Affected By Receptor activity-modifying protein 3 (RAMP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[50]

Drug(s) Affected By Nucleolar protein 3 (NOL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[40]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[102]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[42]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[118]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[119]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[115]

Drug(s) Affected By Slit homolog 1 protein (SLIT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[120]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[120]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[120]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[121]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[122]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[43]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[43]

Drug(s) Affected By Transcription factor Maf (MAF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[124]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[125]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[126]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[127]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[34]

Drug(s) Affected By Histone deacetylase complex subunit SAP30 (SAP30)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[128]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[48]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[40]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[130]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[131]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[132]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[124]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[133]

Drug(s) Affected By Carboxypeptidase D (CPD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[36]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[134]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[49]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[135]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[40]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[136]

Drug(s) Affected By Ribosomal L1 domain-containing protein 1 (RSL1D1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[137]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[74]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[47]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[40]

Drug(s) Affected By Annexin A9 (ANXA9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[140]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[140]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[141]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[79]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[133]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[43]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[142]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[143]

Drug(s) Affected By Cyclin-dependent kinase-like 5 (CDKL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[144]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[119]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[145]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[147]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[111]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[148]

Drug(s) Affected By Contactin-5 (CNTN5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[38]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[149]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[68]

Drug(s) Affected By Phospholipid-transporting ATPase VB (ATP10B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[150]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[112]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[130]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[151]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[152]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[48]

Drug(s) Affected By Transmembrane and coiled-coil domains protein 1 (TMCC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[153]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[112]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[42]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[38]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[115]

Drug(s) Affected By D-glucuronyl C5-epimerase (GLCE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[101]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[37]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[48]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[112]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[154]

Drug(s) Affected By Glutaminase kidney isoform, mitochondrial (GLS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[108]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[155]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[90]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[156]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[49]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[157]

Drug(s) Affected By Protein FAM13A (FAM13A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[50]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[47]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[158]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[159]
Vandetanib	DMRICNP	Solid tumour/cancer	2A00-2F9Z	Approved	[160]

Drug(s) Affected By Fibrinogen silencer-binding protein (RAD54B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[54]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[156]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[135]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[130]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[113]

Drug(s) Affected By Chondroitin sulfate proteoglycan 5 (CSPG5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[161]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[162]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[130]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[79]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[122]
Sodium phenylbutyrate	DMXLBCQ	Spinal muscular atrophy	8B61	Approved	[163]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[68]

Drug(s) Affected By RAS guanyl-releasing protein 1 (RASGRP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[112]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[164]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Indomethacin	DMSC4A7	Bursitis		Approved	[165]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[166]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[167]

Drug(s) Affected By BAG family molecular chaperone regulator 4 (BAG4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[168]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[169]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[102]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[170]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[119]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[109]

Drug(s) Affected By Olfactory receptor 2H2 (OR2H2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[154]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[172]

Drug(s) Affected By G1/S-specific cyclin-E2 (CCNE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[54]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[173]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[62]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[108]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[174]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[175]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[176]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[177]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[93]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[74]

Drug(s) Affected By Alpha-lactalbumin (LALBA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]

Drug(s) Affected By Glycoprotein hormones alpha chain (CGA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[156]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[49]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[178]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Octreotide	DMHIDCJ	Acromegaly	5A60.0	Approved	[179]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[180]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[181]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[183]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[184]

Drug(s) Affected By Interferon alpha-21 (IFNA21)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[185]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[186]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[187]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[188]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[55]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[189]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[55]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[190]
Selenium	DM25CGV	N. A.	N. A.	Approved	[191]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[192]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[193]

Drug(s) Affected By Erythropoietin (EPO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[194]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[195]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[196]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[197]
Fenoterol	DMIP3ZV	Asthma	CA23	Approved	[198]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[199]
Enalapril	DMNFUZR	Congestive heart failure	BD10	Approved	[200]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[201]

Drug(s) Affected By Apolipoprotein C-II (APOC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[123]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[141]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[202]

Drug(s) Affected By Fibrinogen beta chain (FGB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[203]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[157]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[79]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[204]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[205]

Drug(s) Affected By Hemopexin (HPX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[85]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[207]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[79]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[208]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[53]

Drug(s) Affected By Granulocyte-macrophage colony-stimulating factor (CSF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[209]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[210]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[211]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[212]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[213]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[214]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[37]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[215]
Acetylcholine	DMDF79Z	Cataract	9B10	Approved	[216]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[217]

Drug(s) Affected By Trefoil factor 1 (TFF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[218]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[34]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[219]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[220]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[221]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[222]
Reserpine	DM6VM38	Hypertension	BA00-BA04	Approved	[219]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[223]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[224]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[225]

Drug(s) Affected By Plasma serine protease inhibitor (SERPINA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[224]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[162]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[226]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[130]
ARZOXIFENE	DMOKCVI	Breast cancer	2C60-2C65	Approved	[227]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[79]

Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[228]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[229]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[230]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[231]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[232]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[187]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[23]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[190]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[233]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[228]

Drug(s) Affected By Intercellular adhesion molecule 1 (ICAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[234]
Dicloxacillin	DM8EU0Z	Bacterial infection	1A00-1C4Z	Approved	[234]
Ergonovine	DM0VEC1	Postpartum haemorrhage	JA43	Approved	[17]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[235]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[236]
Mizolastine	DM1FDN8	Allergic rhinitis	CA08.0	Approved	[237]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[209]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[238]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[239]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[240]

Drug(s) Affected By T-cell surface antigen CD2 (CD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[27]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[36]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[130]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[241]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[166]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[242]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[47]

Drug(s) Affected By Neurofilament light polypeptide (NEFL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[243]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[243]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[244]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[40]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[112]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[130]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[243]

Drug(s) Affected By Neurofilament medium polypeptide (NEFM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[245]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[50]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[246]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[247]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[40]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[112]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[248]
Lidocaine	DML4ZOT	Anaesthesia	9A78.6	Approved	[249]

Drug(s) Affected By Platelet glycoprotein Ib alpha chain (GP1BA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[250]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[133]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[251]
ANW-32821	DMMJOZD	N. A.	N. A.	Phase 2	[252]

Drug(s) Affected By T-cell surface glycoprotein CD3 epsilon chain (CD3E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[41]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[242]
GSK618334	DMJPXZ4	Drug abuse	6C4G.1Z	Phase 1	[253]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]

Drug(s) Affected By Inhibin beta A chain (INHBA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[156]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[91]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[49]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[254]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[255]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[77]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[256]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[154]

Drug(s) Affected By Monocyte differentiation antigen CD14 (CD14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[257]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[123]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[258]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[72]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[259]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[260]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[93]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[261]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]

Drug(s) Affected By Fibroblast growth factor 4 (FGF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[262]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[171]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[17]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[263]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[43]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[43]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[48]

Drug(s) Affected By Alpha-2A adrenergic receptor (ADRA2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[154]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[17]
Rilmenidine	DM13PQW	Hypertension	BA00-BA04	Approved	[264]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[36]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[161]
Oxymetazoline	DM8ZXT6	Arrhythmia	BC9Z	Approved	[265]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Indapamide	DMGN1PW	Edema	MG29	Approved	[266]

Drug(s) Affected By Homeobox protein Hox-D4 (HOXD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Indomethacin	DMSC4A7	Bursitis		Approved	[165]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[166]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[115]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[53]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[115]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[109]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[50]

Drug(s) Affected By Growth-regulated alpha protein (CXCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[230]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[267]
Selenium	DM25CGV	N. A.	N. A.	Approved	[191]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[108]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[140]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[243]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[228]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[243]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[268]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[269]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[270]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[231]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[271]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[187]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[272]
Selenium	DM25CGV	N. A.	N. A.	Approved	[273]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[240]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[274]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[56]

Drug(s) Affected By Tumor-associated calcium signal transducer 2 (TACSTD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[34]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[108]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[243]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[243]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[275]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[37]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[49]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]

Drug(s) Affected By Polyunsaturated fatty acid 5-lipoxygenase (ALOX5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[276]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[277]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[278]
Fructose	DM43AN2	Vomiting	MD90	Approved	[279]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[280]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[281]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[112]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[282]

Drug(s) Affected By Adenosine receptor A3 (ADORA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[283]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[128]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[224]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Adenosine	DMM2NSK	Paroxysmal supraventricular tachycardia	BC81.Z	Approved	[284]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[285]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[286]
Indomethacin	DMSC4A7	Bursitis		Approved	[287]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[288]

Drug(s) Affected By Heat shock 70 kDa protein 1A (HSPA1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[289]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[270]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[257]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[188]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[290]
Selenium	DM25CGV	N. A.	N. A.	Approved	[81]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[291]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[27]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[211]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[292]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[293]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[294]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[231]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[295]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[187]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[55]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[189]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[296]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[55]

Drug(s) Affected By COUP transcription factor 1 (NR2F1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[297]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[36]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[101]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[37]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[49]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[130]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[298]

Drug(s) Affected By Clusterin (CLU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[299]
Selenium	DM25CGV	N. A.	N. A.	Approved	[81]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[299]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Levamisole	DM5EN79	Parasitic infection	1D0Y-1G2Z	Approved	[300]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[72]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[37]
Methazolamide	DM7J2TA	Glaucoma/ocular hypertension	9C61	Approved	[299]

Drug(s) Affected By High affinity immunoglobulin gamma Fc receptor I (FCGR1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[301]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[79]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[128]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
Maleic Acid	DM4L0R7	Discovery agent	N.A.	Investigative	[302]
Rapamycin Immunosuppressant Drug	DM678IB	Discovery agent	N.A.	Investigative	[301]
PHENCYCLIDINE	DMQBEYX	Discovery agent	N.A.	Investigative	[303]
paraquat	DMR8O3X	Discovery agent	N.A.	Investigative	[304]

Drug(s) Affected By Bone morphogenetic protein 2 (BMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[305]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[306]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[307]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[308]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[49]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[309]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[47]

Drug(s) Affected By Cytochrome P450 4B1 (CYP4B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[310]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[311]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[73]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[141]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[255]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[112]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[79]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[312]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[313]

Drug(s) Affected By Sodium/glucose cotransporter 1 (SLC5A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[314]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[91]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[315]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[119]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[53]
3,4-Dihydroxycinnamic Acid	DMVZL26	Thrombocytopenia	3B64	Phase 4	[316]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[317]
CERC-801	DM3SZ7P	N. A.	N. A.	Phase 2	[318]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[68]

Drug(s) Affected By Phospholipase A2, membrane associated (PLA2G2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[27]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[319]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[320]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[140]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[77]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[321]

Drug(s) Affected By Glutamine synthetase (GLUL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[243]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[243]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[98]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[91]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[49]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[162]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[40]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[322]

Drug(s) Affected By Interferon gamma receptor 1 (IFNGR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[186]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[34]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[56]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[101]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[178]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[322]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[323]

Drug(s) Affected By Antigen-presenting glycoprotein CD1d (CD1D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[27]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[175]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[137]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[48]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[83]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[79]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[38]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[171]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[242]

Drug(s) Affected By Platelet endothelial cell adhesion molecule (PECAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[324]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[325]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[326]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[327]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[328]
Asasantin	DMCZIHT	Cerebrovascular ischaemia	8B1Z	Approved	[329]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[330]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[331]

Drug(s) Affected By T-cell acute lymphocytic leukemia protein 1 (TAL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[332]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[333]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[53]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[334]

Drug(s) Affected By Bone morphogenetic protein 7 (BMP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[335]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[336]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[337]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[338]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[339]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[119]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[115]

Drug(s) Affected By Erythropoietin receptor (EPOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[340]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[332]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[341]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[312]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[119]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[43]

Drug(s) Affected By C-X-C motif chemokine 2 (CXCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[230]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[34]
Selenium	DM25CGV	N. A.	N. A.	Approved	[191]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[108]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[228]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[275]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[342]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]

Drug(s) Affected By Transcobalamin-1 (TCN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[112]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[130]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[111]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[334]

Drug(s) Affected By Kallikrein-2 (KLK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[343]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[344]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[93]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[345]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[124]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Dutasteride	DMQ4TJK	Benign prostatic hyperplasia	GA90	Approved	[346]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[166]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[347]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[348]

Drug(s) Affected By Interferon-induced GTP-binding protein Mx2 (MX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[108]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[349]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[138]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[350]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[130]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[77]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[351]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[166]

Drug(s) Affected By Collagen alpha-1(V) chain (COL5A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[36]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[352]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[353]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[77]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[354]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[41]

Drug(s) Affected By Amine oxidase A (MAOA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[56]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[349]
Selegiline	DM6034S	Major depressive disorder	6A70.3	Approved	[355]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[137]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[356]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]

Drug(s) Affected By Tumor necrosis factor alpha-induced protein 3 (TNFAIP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[357]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[230]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[358]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[357]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[359]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[360]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[361]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[357]

Drug(s) Affected By Catechol O-methyltransferase (COMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[362]
Dobutamine	DMD1B8Z	Heart failure	BD10-BD13	Approved	[362]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[362]
Modafinil	DMYILBE	Malignant glioma	2A00.0	Approved	[363]
Levodopa	DMN3E57	Parkinson disease	8A00.0	Approved	[362]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[335]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[364]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Tolcapone	DM8MNVO	Parkinson disease	8A00.0	Approved	[365]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fructose	DM43AN2	Vomiting	MD90	Approved	[366]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[128]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[367]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[91]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[47]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[159]
Mirtazapine	DML53ZJ	Depression	6A70-6A7Z	Approved	[368]
Methamphetamine	DMPM4SK	Anxiety		Approved	[369]

Drug(s) Affected By Carbonic anhydrase 4 (CA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[150]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[94]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[94]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[166]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[43]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[115]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[115]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[48]

Drug(s) Affected By Fibulin-1 (FBLN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[50]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[34]
Selenium	DM25CGV	N. A.	N. A.	Approved	[81]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[228]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[228]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[36]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[370]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[224]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[40]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 4 (TNFSF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[153]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[27]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[371]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[47]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[102]

Drug(s) Affected By Endothelin receptor type B (EDNRB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[246]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[120]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[161]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[315]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[255]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[372]

Drug(s) Affected By Insulin-like growth factor-binding protein 5 (IGFBP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[335]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[290]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[120]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[36]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[373]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[374]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[158]

Drug(s) Affected By Acrosomal protein SP-10 (ACRV1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[166]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]

Drug(s) Affected By Interleukin-1 receptor type 2 (IL1R2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[34]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[27]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[85]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[36]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[375]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[224]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[336]

Drug(s) Affected By Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[376]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[377]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[378]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[379]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[380]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[381]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[37]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[382]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]

Drug(s) Affected By T-cell surface glycoprotein CD1c (CD1C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[81]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]

Drug(s) Affected By HLA class I histocompatibility antigen, alpha chain F (HLA-F)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[383]
Selenium	DM25CGV	N. A.	N. A.	Approved	[81]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[383]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[175]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[120]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[36]
Repaglinide	DM5SXUV	Diabetic complication	5A2Y	Approved	[383]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[384]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Saquinavir	DMG814N	Human immunodeficiency virus infection	1C62	Approved	[383]

Drug(s) Affected By Pyruvate kinase PKLR (PKLR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[85]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[36]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[61]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[385]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[85]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[85]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[76]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[41]

Drug(s) Affected By Olfactory receptor 10J1 (OR10J1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone undecanoate	DMZO10Y	Hypogonadism	5A61.0	Approved	[386]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]

Drug(s) Affected By Homeobox protein Hox-D3 (HOXD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[37]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[387]
Indomethacin	DMSC4A7	Bursitis		Approved	[165]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[388]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[115]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[115]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[389]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
Rutin	DMEHRAJ	Discovery agent	N.A.	Investigative	[390]

Drug(s) Affected By Sodium- and chloride-dependent taurine transporter (SLC6A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[50]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[378]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[101]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[248]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[130]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[113]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[391]

Drug(s) Affected By Cytochrome P450 2C19 (CYP2C19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[392]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[393]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[394]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[395]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[396]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[397]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[398]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[397]
Desipramine	DMT2FDC	Attention deficit hyperactivity disorder	6A05.Z	Approved	[393]
Amitriptyline	DMK7F9S	Depression	6A70-6A7Z	Approved	[17]

Drug(s) Affected By Ribonuclease 4 (RNASE4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[85]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[378]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[113]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[42]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[38]

Drug(s) Affected By Cannabinoid receptor 2 (CNR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Guanfacine extended release	DMB1CZ8	Attention deficit hyperactivity disorder	6A05.Z	Approved	[399]
NABILONE	DMVRYT2	Insomnia	7A00-7A0Z	Approved	[400]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[401]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[402]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[403]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[102]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[404]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[405]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[166]

Drug(s) Affected By Merlin (NF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[364]
Selenium	DM25CGV	N. A.	N. A.	Approved	[81]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[108]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[406]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[407]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[40]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[285]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[34]

Drug(s) Affected By Nuclear receptor ROR-alpha (RORA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[50]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[36]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[161]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[408]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[158]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[409]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[85]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[270]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[410]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[257]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[411]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[412]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[290]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[413]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[414]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[415]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]

Drug(s) Affected By Chitinase-3-like protein 1 (CHI3L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[320]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[36]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[416]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[275]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[101]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[224]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[248]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[417]

Drug(s) Affected By Amiloride-sensitive sodium channel subunit alpha (SCNN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[418]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[419]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[420]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[224]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[421]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]

Drug(s) Affected By B-cell lymphoma 6 protein (BCL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[422]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[422]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[422]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[52]
Bortezomib	DMNO38U	Leukemia		Approved	[136]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]

Drug(s) Affected By Regulator of G-protein signaling 2 (RGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[34]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[27]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[423]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[424]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[101]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[37]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[244]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]

Drug(s) Affected By C-X-C motif chemokine 5 (CXCL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[54]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[267]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[72]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[425]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[255]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[112]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[426]

Drug(s) Affected By ATP-binding cassette sub-family G member 1 (ABCG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[427]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[428]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[101]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[74]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[74]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[422]

Drug(s) Affected By 5-hydroxytryptamine receptor 3A (HTR3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[17]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[94]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[429]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[150]
Metoclopramide	DMFA5MY	Nausea	MD90	Approved	[430]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[431]
Hydromorphone	DMHP21E	Back pain	ME84.Z	Approved	[432]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[85]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[429]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[94]

Drug(s) Affected By DNA-binding protein inhibitor ID-4 (ID4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[112]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[433]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[337]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[166]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[434]

Drug(s) Affected By Serpin B4 (SERPINB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[435]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[108]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[320]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[435]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[144]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[144]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[119]

Drug(s) Affected By Beta-arrestin-1 (ARRB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[108]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[436]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Bortezomib	DMNO38U	Leukemia		Approved	[136]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[94]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[154]

Drug(s) Affected By Retinoic acid receptor responder protein 1 (RARRES1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[168]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[228]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[168]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[437]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[106]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[168]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[168]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[77]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[228]

Drug(s) Affected By Cytosolic purine 5'-nucleotidase (NT5C2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[120]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[438]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[40]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[120]
Bortezomib	DMNO38U	Leukemia		Approved	[136]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[120]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[41]

Drug(s) Affected By RNA-binding protein FXR1 (FXR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[34]
Selenium	DM25CGV	N. A.	N. A.	Approved	[81]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[109]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[40]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[41]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[42]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[119]

Drug(s) Affected By Stanniocalcin-1 (STC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[50]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[439]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[85]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[440]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[101]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[158]

Drug(s) Affected By Protein FosB (FOSB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[270]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[128]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[36]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[100]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[441]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[101]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[140]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[150]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[442]

Drug(s) Affected By LIM domain kinase 1 (LIMK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[244]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[443]
Ximelegatran	DMU8ANS	Myocardial infarction	BA41-BA43	Approved	[444]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[79]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[445]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[312]

Drug(s) Affected By Beta-crystallin B1 (CRYBB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[52]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[41]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[446]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]

Drug(s) Affected By DNA polymerase subunit gamma-1 (POLG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[447]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[448]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[41]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[154]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[119]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[448]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[449]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[450]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[133]

Drug(s) Affected By Heat shock-related 70 kDa protein 2 (HSPA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[230]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[34]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[451]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[452]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[453]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[454]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[374]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]

Drug(s) Affected By Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (PDE1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[161]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[455]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[40]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[112]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[166]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[312]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[456]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[115]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[457]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[50]

Drug(s) Affected By GTP-binding protein RAD (RRAD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[91]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[49]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[138]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[47]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[458]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[130]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[459]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]

Drug(s) Affected By Aquaporin-5 (AQP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[460]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[461]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[224]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[462]
Carbachol	DMX9K8F	Glaucoma/ocular hypertension	9C61	Approved	[463]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[464]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[111]
cordycepin	DM72Y01	Discovery agent	N.A.	Investigative	[460]

Drug(s) Affected By Galectin-4 (LGALS4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[465]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[53]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[466]
Capecitabine	DMTS85L	Adenocarcinoma	2D40	Approved	[466]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[87]

Drug(s) Affected By Potassium voltage-gated channel subfamily KQT member 4 (KCNQ4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Retigabine	DMGNYIH	Behcet disease	4A62	Approved	[467]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[120]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[120]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[41]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[312]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[468]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[469]

Drug(s) Affected By Serine/threonine-protein kinase SIK1 (SIK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[91]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[74]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[150]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[74]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[74]

Drug(s) Affected By A disintegrin and metalloproteinase with thrombospondin motifs 12 (ADAMTS12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[154]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[119]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[151]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[53]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[87]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[68]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[50]

Drug(s) Affected By C-X-C chemokine receptor type 4 (CXCR4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[168]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[34]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[228]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[470]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[471]
Carfilzomib	DM48K0X	Multiple myeloma	2A83	Approved	[472]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[228]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[473]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[474]

Drug(s) Affected By Rho-related GTP-binding protein RhoE (RND3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[270]
Selenium	DM25CGV	N. A.	N. A.	Approved	[81]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[415]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[36]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[475]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[74]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]

Drug(s) Affected By Small ribosomal subunit protein eS8 (RPS8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[476]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[40]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[477]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[109]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[478]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[479]

Drug(s) Affected By Protein jagged-1 (JAG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[34]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[480]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[98]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[481]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[482]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[248]

Drug(s) Affected By Arginase-2, mitochondrial (ARG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[230]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Selenium	DM25CGV	N. A.	N. A.	Approved	[81]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[415]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[36]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[483]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[66]

Drug(s) Affected By C-C motif chemokine 20 (CCL20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[230]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[187]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[267]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[228]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[484]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[228]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[49]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[485]

Drug(s) Affected By Neutrophil gelatinase-associated lipocalin (LCN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[230]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[243]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[243]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[486]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[91]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[224]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[112]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[487]

Drug(s) Affected By Zinc finger protein basonuclin-1 (BNC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[50]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[101]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[126]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[456]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[53]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[181]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[488]

Drug(s) Affected By DNA-binding protein inhibitor ID-2 (ID2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Selenium	DM25CGV	N. A.	N. A.	Approved	[81]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[489]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[490]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[422]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[90]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[137]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[489]

Drug(s) Affected By Mucin-2 (MUC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[108]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[246]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[491]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[492]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[493]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[388]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[446]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[468]

Drug(s) Affected By Cytochrome P450 4A11 (CYP4A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[494]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[495]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[495]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[27]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[243]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[243]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[495]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[495]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[495]

Drug(s) Affected By Homeobox protein EMX2 (EMX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[459]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[496]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[43]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[50]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[48]

Drug(s) Affected By Proto-oncogene c-Rel (REL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[272]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[497]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[498]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[162]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[47]
Norepinephrine	DMOUC09	Alopecia	ED70	Approved	[499]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[500]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[241]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[501]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[312]

Drug(s) Affected By Neuronal acetylcholine receptor subunit beta-3 (CHRNB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[336]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[285]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[446]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[50]
AM251	DMTAWHL	Discovery agent	N.A.	Investigative	[502]

Drug(s) Affected By Myocyte-specific enhancer factor 2C (MEF2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[36]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[130]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[285]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[503]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[41]

Drug(s) Affected By Adenylate cyclase type 2 (ADCY2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[41]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[115]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[53]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[43]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[68]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[504]

Drug(s) Affected By 3',5'-cyclic-AMP phosphodiesterase 4D (PDE4D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[50]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[61]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[40]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[130]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]

Drug(s) Affected By Killer cell lectin-like receptor subfamily B member 1 (KLRB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[100]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[505]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[506]

Drug(s) Affected By Ankyrin-3 (ANK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[168]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[50]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[137]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[52]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[127]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[34]

Drug(s) Affected By Heat shock protein beta-3 (HSPB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[49]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[130]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[507]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[119]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[53]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[68]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[111]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[508]

Drug(s) Affected By AP-3 complex subunit beta-2 (AP3B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[133]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[115]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[468]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[509]
Manganese	DMKT129	N. A.	N. A.	Investigative	[510]

Drug(s) Affected By Unconventional myosin-VIIa (MYO7A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[41]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[511]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[109]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[48]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase FKBP5 (FKBP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[128]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[379]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[512]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[513]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[93]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[93]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[514]

Drug(s) Affected By Mucosal addressin cell adhesion molecule 1 (MADCAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[79]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[43]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]

Drug(s) Affected By Calcium/calmodulin-dependent protein kinase type II subunit gamma (CAMK2G)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[56]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[378]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[156]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[40]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[515]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[119]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[81]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[477]

Drug(s) Affected By Interferon regulatory factor 5 (IRF5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[34]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[516]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[34]
Diphenylpyraline	DMW4X37	Allergic rhinitis	CA08.0	Approved	[517]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[516]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]

Drug(s) Affected By Runt-related transcription factor 3 (RUNX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[120]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[408]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[120]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[337]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[120]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[518]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[41]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[519]

Drug(s) Affected By Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[270]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[520]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[521]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[522]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[523]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[452]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[524]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[90]

Drug(s) Affected By Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (ENPP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[228]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[156]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[525]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[150]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[47]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[85]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[526]

Drug(s) Affected By Plakophilin-1 (PKP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[108]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[36]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[453]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[527]

Drug(s) Affected By Krueppel-like factor 9 (KLF9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[153]
Selenium	DM25CGV	N. A.	N. A.	Approved	[81]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[489]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[128]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[275]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[489]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[489]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[528]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]

Drug(s) Affected By Transcription factor Dp-2 (TFDP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[128]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[36]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[280]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[102]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[433]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[354]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[286]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[529]

Drug(s) Affected By Calcipressin-2 (RCAN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[79]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[119]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[53]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[87]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[50]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[47]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[48]

Drug(s) Affected By Transcription factor E2F2 (E2F2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[230]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[34]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[174]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[530]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[93]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[93]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]

Drug(s) Affected By Enhancer of filamentation 1 (NEDD9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[243]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[243]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[74]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[74]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[74]

Drug(s) Affected By Interleukin-13 receptor subunit alpha-2 (IL13RA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[178]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[255]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[112]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[130]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[531]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[532]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[533]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[534]

Drug(s) Affected By Potassium voltage-gated channel subfamily B member 1 (KCNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[77]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[41]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[119]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[506]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[48]

Drug(s) Affected By FXYD domain-containing ion transport regulator 3 (FXYD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[374]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[93]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[48]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[535]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[127]
Raltitrexed	DMT9K8G	Rectal adenocarcinoma	2B92	Approved	[535]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[535]

Drug(s) Affected By Retinoblastoma-binding protein 5 (RBBP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[40]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[536]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[102]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[351]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[537]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[154]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[119]

Drug(s) Affected By Corneodesmosin (CDSN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[140]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[91]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[140]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[166]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[111]

Drug(s) Affected By Transcription initiation factor TFIID subunit 13 (TAF13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[162]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[312]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[465]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[133]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[38]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[538]

Drug(s) Affected By BDNF/NT-3 growth factors receptor (NTRK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[23]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[539]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[36]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[161]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[540]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[541]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[112]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[503]

Drug(s) Affected By Hypoxia-inducible factor 1-alpha (HIF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[542]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[543]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[544]
Triamterene	DM2HU9I	Congestive heart failure	BD10	Approved	[544]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[545]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[546]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[547]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[470]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[97]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[548]

Drug(s) Affected By Carbonic anhydrase 9 (CA9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetazolamide	DM1AF5U	Absence epilepsy		Approved	[103]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[545]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[549]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[91]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[224]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[57]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[130]
Bortezomib	DMNO38U	Leukemia		Approved	[550]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]

Drug(s) Affected By Reticulon-1 (RTN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[36]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[40]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[41]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[154]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[43]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[456]

Drug(s) Affected By Carcinoembryonic antigen-related cell adhesion molecule 21 (CEACAM21)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]

Drug(s) Affected By Transmembrane protein 176B (TMEM176B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[108]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[224]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[79]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[119]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[68]

Drug(s) Affected By Mitogen-activated protein kinase kinase kinase 19 (MAP3K19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[50]

Drug(s) Affected By Transmembrane protein 255A (TMEM255A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[53]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[133]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[50]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[111]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[48]

Drug(s) Affected By Protein THEMIS2 (THEMIS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[451]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[128]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[119]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[133]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[128]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[43]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[551]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[505]

Drug(s) Affected By Myomegalin (PDE4DIP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[98]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[137]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[541]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[78]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[541]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[41]

Drug(s) Affected By Kazrin (KAZN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[41]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[552]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[151]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[181]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[181]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[181]

Drug(s) Affected By Protein aurora borealis (BORA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[245]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[177]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[553]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[248]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[113]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[554]

Drug(s) Affected By Kelch-like protein 24 (KLHL24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[34]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[422]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[156]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[138]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[422]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[47]

Drug(s) Affected By BEN domain-containing protein 5 (BEND5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[36]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[74]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[112]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[74]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[74]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[256]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[43]

Drug(s) Affected By Glucosylceramide transporter ABCA12 (ABCA12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[93]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[93]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[47]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[112]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[52]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[555]

Drug(s) Affected By E3 ubiquitin-protein ligase DZIP3 (DZIP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[166]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[556]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[133]
Berberine	DMC5Q8X	N. A.	N. A.	Phase 4	[557]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[68]

Drug(s) Affected By Homeodomain-interacting protein kinase 1 (HIPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[128]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[90]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[156]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[528]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[90]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[41]

Drug(s) Affected By Transmembrane protein 151B (TMEM151B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[52]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[116]

Drug(s) Affected By Calcium-responsive transcription factor (CARF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[34]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[312]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[469]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[68]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[48]
RESORCINOL	DMM37C0	Discovery agent	N.A.	Investigative	[113]

Drug(s) Affected By Chondroitin sulfate N-acetylgalactosaminyltransferase 2 (CSGALNACT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[77]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[42]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[133]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[558]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[57]

Drug(s) Affected By RalBP1-associated Eps domain-containing protein 2 (REPS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[83]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[112]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[559]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[53]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[124]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[133]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[559]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]

Drug(s) Affected By Centrosomal protein of 76 kDa (CEP76)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[154]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[114]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[133]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[87]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[68]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[109]

Drug(s) Affected By DEP domain-containing mTOR-interacting protein (DEPTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[50]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[560]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[112]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[248]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[77]

Drug(s) Affected By Dynein axonemal heavy chain 3 (DNAH3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Haloperidol	DM96SE0	Delirium		Approved	[435]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[133]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[468]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[469]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[50]

Drug(s) Affected By Partitioning defective 3 homolog (PARD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[109]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[120]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[40]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[120]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]

Drug(s) Affected By GATOR1 complex protein NPRL2 (NPRL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[120]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[120]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[94]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[120]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[119]

Drug(s) Affected By DnaJ homolog subfamily A member 4 (DNAJA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[52]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[561]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[42]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[119]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[53]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[68]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[116]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[111]

Drug(s) Affected By Aquaporin-3 (AQP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[81]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[358]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[367]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[91]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[57]

Drug(s) Affected By Zinc transporter SLC39A7 (SLC39A7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[314]
Selenium	DM25CGV	N. A.	N. A.	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[181]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[124]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[57]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[109]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[562]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[563]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[148]

Drug(s) Affected By Carnitine O-palmitoyltransferase 1, muscle isoform (CPT1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[564]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[72]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[565]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[130]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[43]

Drug(s) Affected By Sortilin-related receptor (SORL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[74]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[74]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[48]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[74]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[74]

Drug(s) Affected By Amyloid beta precursor protein binding family B member 2 (APBB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[161]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[34]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[154]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[119]

Drug(s) Affected By Far upstream element-binding protein 1 (FUBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[175]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[566]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[40]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[435]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[41]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[42]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[119]

Drug(s) Affected By Serine/threonine-protein kinase Sgk3 (SGK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[104]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[104]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[101]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Mestranol	DMG3F94	Contraception	QA21	Approved	[104]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[104]

Drug(s) Affected By Rho guanine nucleotide exchange factor 26 (ARHGEF26)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[50]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[120]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[40]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[120]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[120]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[80]

Drug(s) Affected By ATP-dependent DNA helicase DDX11 (DDX11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[93]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[93]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Bortezomib	DMNO38U	Leukemia		Approved	[136]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[41]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[567]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[477]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[87]

Drug(s) Affected By Unconventional myosin-XVB (MYO15B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[42]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[468]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[109]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[50]

Drug(s) Affected By Testis-specific serine/threonine-protein kinase 2 (TSSK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]

Drug(s) Affected By M-phase phosphoprotein 8 (MPHOSPH8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[528]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[40]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[42]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[568]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[511]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[109]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[109]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[77]

Drug(s) Affected By Calcineurin B homologous protein 1 (CHP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[36]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[40]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[569]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[166]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[119]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[133]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[469]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[68]

Drug(s) Affected By G-protein coupled receptor 20 (GPR20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[120]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[120]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[154]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[312]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[48]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[63]

Drug(s) Affected By Pituitary homeobox 2 (PITX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[34]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[246]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[34]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[38]
Nicotinamide	DMUPE07	Acne vulgaris	ED80	Approved	[570]

Drug(s) Affected By Lysosomal-trafficking regulator (LYST)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[40]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[433]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[459]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[312]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[119]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[465]

Drug(s) Affected By Sperm-associated antigen 8 (SPAG8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[40]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[166]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[133]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[68]

Drug(s) Affected By Growth/differentiation factor 15 (GDF15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[270]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[290]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[62]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[89]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[246]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[571]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[243]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[243]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[572]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[573]

Drug(s) Affected By Galactosylceramide sulfotransferase (GAL3ST1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[34]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[127]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[34]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[166]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[53]
Fenretinide	DMRD5SP	Macular degeneration	9B78.3	Phase 3	[574]

Drug(s) Affected By Transcription factor Ovo-like 2 (OVOL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[312]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[171]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[133]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[389]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[48]

Drug(s) Affected By Glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[270]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[422]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[575]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[560]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[270]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[483]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[575]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Racecadotril	DMFOTZ7	Diarrhea	ME05.1	Approved	[576]

Drug(s) Affected By Sorbin and SH3 domain-containing protein 1 (SORBS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[109]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[36]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[47]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[77]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[577]

Drug(s) Affected By Transient receptor potential cation channel subfamily M member 6 (TRPM6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[108]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[81]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]

Drug(s) Affected By Partitioning defective 6 homolog beta (PARD6B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[40]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[53]
G1	DMTV42K	Lymphoma	2A80-2A86	Phase 1/2	[578]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[579]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[68]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[109]

Drug(s) Affected By Sialoadhesin (SIGLEC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[87]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[109]

Drug(s) Affected By INO80 complex subunit B (INO80B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Bortezomib	DMNO38U	Leukemia		Approved	[136]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[462]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[57]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[109]
AHPN	DM8G6O4	Discovery agent	N.A.	Investigative	[580]

Drug(s) Affected By N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 4 (B3GNT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[83]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
uric acid	DMA1MKT	Discovery agent	N.A.	Investigative	[581]

Drug(s) Affected By GDNF family receptor alpha-4 (GFRA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[511]

Drug(s) Affected By Polyadenylate-binding protein-interacting protein 1 (PAIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[364]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[47]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[40]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[120]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[120]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[42]

Drug(s) Affected By Large subunit GTPase 1 homolog (LSG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[108]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[120]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[120]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[120]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[312]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]

Drug(s) Affected By Cysteine-rich secretory protein LCCL domain-containing 2 (CRISPLD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[91]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[224]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[255]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[248]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[130]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[310]

Drug(s) Affected By Stathmin-4 (STMN4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[52]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[94]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[94]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[86]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[115]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]

Drug(s) Affected By Matrix metalloproteinase-28 (MMP28)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[423]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[137]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[41]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[53]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[87]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[508]

Drug(s) Affected By Dendritic cell-specific transmembrane protein (DCSTAMP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[83]
Methamphetamine	DMPM4SK	Anxiety		Approved	[582]
ANW-32821	DMMJOZD	N. A.	N. A.	Phase 2	[252]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[558]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
PMID27336223-Compound-5	DM6E50A	N. A.	N. A.	Patented	[83]

Drug(s) Affected By 2-aminomuconic semialdehyde dehydrogenase (ALDH8A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[576]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[422]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Racecadotril	DMFOTZ7	Diarrhea	ME05.1	Approved	[576]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[85]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[76]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[112]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[113]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[42]

Drug(s) Affected By Tumor protein 63 (TP63)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[50]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[583]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[584]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[585]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[224]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[150]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[459]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[586]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]

Drug(s) Affected By Prolyl hydroxylase EGLN3 (EGLN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[391]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[38]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[119]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[115]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[53]

Drug(s) Affected By E3 ubiquitin-protein transferase RMND5A (RMND5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[128]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[40]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[42]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[133]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[128]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]

Drug(s) Affected By Glyoxalase domain-containing protein 4 (GLOD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[128]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[120]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[40]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[587]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[120]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[120]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[588]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[119]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[128]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[68]

Drug(s) Affected By Transient receptor potential cation channel subfamily M member 3 (TRPM3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[156]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[254]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[79]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[43]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[171]
Methamphetamine	DMPM4SK	Anxiety		Approved	[582]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[43]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]

Drug(s) Affected By X-linked interleukin-1 receptor accessory protein-like 2 (IL1RAPL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]

Drug(s) Affected By DNA-directed DNA/RNA polymerase mu (POLM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[120]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[120]
Bortezomib	DMNO38U	Leukemia		Approved	[136]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[120]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[170]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[119]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[109]
MK-886	DMT0O7H	Asthma	CA23	Discontinued in Phase 2	[589]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[109]

Drug(s) Affected By Triggering receptor expressed on myeloid cells 1 (TREM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[224]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[178]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[119]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[180]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[590]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[591]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[511]
Nickel chloride	DMI12Y8	Discovery agent	N.A.	Investigative	[591]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[334]

Drug(s) Affected By 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (PLCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[112]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[130]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[391]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Methamphetamine	DMPM4SK	Anxiety		Approved	[592]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[593]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[79]

Drug(s) Affected By PDZ and LIM domain protein 7 (PDLIM7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[81]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[89]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[137]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[100]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]

Drug(s) Affected By Spectrin beta chain, non-erythrocytic 5 (SPTBN5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[101]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[79]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[81]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[68]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[50]

Drug(s) Affected By Dual oxidase 2 (DUOX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[594]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[156]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[154]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[115]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
D-glucose	DMMG2TO	Discovery agent	N.A.	Investigative	[595]
paraquat	DMR8O3X	Discovery agent	N.A.	Investigative	[304]

Drug(s) Affected By Ubiquitin-like-conjugating enzyme ATG3 (ATG3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[596]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[120]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[597]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[598]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[40]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[120]
Artesunate	DMR27C8	Infection of P. falciparum	1F40	Approved	[599]

Drug(s) Affected By Transmembrane protein 140 (TMEM140)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[153]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[113]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[166]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[57]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[133]

Drug(s) Affected By Transmembrane protein 45A (TMEM45A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[34]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[52]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[74]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[600]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[42]

Drug(s) Affected By Leucine-rich repeat transmembrane protein FLRT3 (FLRT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[34]
Selenium	DM25CGV	N. A.	N. A.	Approved	[81]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[601]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[49]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[48]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[40]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[52]

Drug(s) Affected By Dickkopf-related protein 4 (DKK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[602]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[57]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[603]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[133]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[604]

Drug(s) Affected By Transcription factor 20 (TCF20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[285]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[605]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[133]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[477]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[109]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[606]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[111]

Drug(s) Affected By N-acetyltransferase 8 (NAT8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[73]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[112]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[42]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[38]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[465]

Drug(s) Affected By Tachykinin-3 (TAC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[94]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[94]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[41]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[456]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[171]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[53]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[115]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]

Drug(s) Affected By Zinc finger transcription factor Trps1 (TRPS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[77]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[43]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[43]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[477]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[68]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[109]

Drug(s) Affected By Alpha-methylacyl-CoA racemase (AMACR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[27]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[470]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[36]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[161]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[37]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[93]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[141]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]

Drug(s) Affected By Cytohesin-4 (CYTH4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[130]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[286]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[388]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[166]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[312]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[590]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[63]

Drug(s) Affected By SLAM family member 5 (CD84)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[422]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[422]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[422]
Epanova	DMHEAGL	Hypertriglyceridemia	5C80.1	Approved	[607]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[159]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[422]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[505]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
Rapamycin Immunosuppressant Drug	DM678IB	Discovery agent	N.A.	Investigative	[422]

Drug(s) Affected By Protein Hook homolog 1 (HOOK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[81]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[101]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[224]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[47]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[336]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[526]

Drug(s) Affected By Teneurin-1 (TENM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[27]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[161]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[124]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[559]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[79]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[124]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[133]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[559]

Drug(s) Affected By Carbonic anhydrase 14 (CA14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[123]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[143]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[68]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[334]

Drug(s) Affected By ALK tyrosine kinase receptor (ALK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ceritinib	DMB920Z	Non-small-cell lung cancer	2C25.Y	Approved	[608]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[609]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[610]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[611]
Masoprocol	DMMVNZ0	Prostate cancer	2C82.0	Approved	[610]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[285]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[41]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[612]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[613]
Pemetrexed	DMMX2E6	Central nervous system lymphoma	2B33.5	Approved	[614]

Drug(s) Affected By Endoribonuclease Dicer (DICER1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[57]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[40]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[615]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[286]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[41]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[42]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[616]

Drug(s) Affected By Pregnancy-specific beta-1-glycoprotein 11 (PSG11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[37]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[606]

Drug(s) Affected By Protein phosphatase 1 regulatory subunit 3C (PPP1R3C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[270]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[108]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[320]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[85]

Drug(s) Affected By Solute carrier family 22 member 14 (SLC22A14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[617]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[154]

Drug(s) Affected By E3 ubiquitin-protein ligase DTX4 (DTX4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[49]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[482]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[113]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[42]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[119]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[618]

Drug(s) Affected By Protein EFR3 homolog B (EFR3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[94]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[94]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[619]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[556]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[133]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[551]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[145]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[551]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]

Drug(s) Affected By FERM domain-containing protein 4B (FRMD4B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[48]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[459]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[80]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[119]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[133]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[558]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]

Drug(s) Affected By Tyrosine-protein phosphatase non-receptor type 22 (PTPN22)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[153]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[135]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[65]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[620]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[130]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[351]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[41]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[170]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[149]

Drug(s) Affected By Dehydrogenase/reductase SDR family member 7 (DHRS7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[601]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[40]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[130]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[119]
Oxcarbazepine	DM5PU6O	Epilepsy	8A60-8A68	Approved	[621]

Drug(s) Affected By Nuclear receptor subfamily 2 group E member 1 (NR2E1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[130]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[41]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[43]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[50]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[48]

Drug(s) Affected By Metal-response element-binding transcription factor 2 (MTF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[130]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[41]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[114]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[622]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[81]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[477]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[538]

Drug(s) Affected By Krueppel-like factor 12 (KLF12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[191]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[48]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[130]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[459]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[41]

Drug(s) Affected By Hypoxia-inducible lipid droplet-associated protein (HILPDA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[34]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[228]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[228]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[36]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[90]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[384]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]

Drug(s) Affected By Phosphoserine aminotransferase (PSAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[270]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[320]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[275]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[270]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[74]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[141]

Drug(s) Affected By Calpain-6 (CAPN6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[161]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[102]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[112]
Indomethacin	DMSC4A7	Bursitis		Approved	[165]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[310]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[623]

Drug(s) Affected By D-dopachrome decarboxylase (DDT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[186]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[36]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[40]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[85]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[79]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[552]

Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[269]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[573]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[257]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[340]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[364]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[624]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[625]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[626]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[627]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[628]

Drug(s) Affected By Interleukin-1 alpha (IL1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[230]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[55]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[55]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[23]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[55]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[27]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[628]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[55]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[211]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]

Drug(s) Affected By Macrophage migration inhibitory factor (MIF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[602]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[439]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[629]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[566]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[40]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[630]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[435]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[130]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Fungal Cell membrane ergosterol (Fung CME)	TTQKWA4	NOUNIPROTAC	Modulator	[4]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[5]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (PLCB1)	OT9HYT7A	PLCB1_HUMAN	Gene/Protein Processing	[6]
2-aminomuconic semialdehyde dehydrogenase (ALDH8A1)	OTINY3MW	AL8A1_HUMAN	Gene/Protein Processing	[6]
3',5'-cyclic-AMP phosphodiesterase 4D (PDE4D)	OT1RWFV0	PDE4D_HUMAN	Gene/Protein Processing	[6]
5-hydroxytryptamine receptor 3A (HTR3A)	OTAIV1AK	5HT3A_HUMAN	Gene/Protein Processing	[6]
A disintegrin and metalloproteinase with thrombospondin motifs 12 (ADAMTS12)	OTG7HEA2	ATS12_HUMAN	Gene/Protein Processing	[6]
Acrosomal protein SP-10 (ACRV1)	OTUTG7PL	ASPX_HUMAN	Gene/Protein Processing	[6]
Adenosine receptor A3 (ADORA3)	OTHO1BLK	AA3R_HUMAN	Gene/Protein Processing	[6]
Adenylate cyclase type 2 (ADCY2)	OTYCBR8I	ADCY2_HUMAN	Gene/Protein Processing	[6]
ALK tyrosine kinase receptor (ALK)	OTV3P4V8	ALK_HUMAN	Gene/Protein Processing	[6]
Alpha-2A adrenergic receptor (ADRA2A)	OTZFGOTP	ADA2A_HUMAN	Gene/Protein Processing	[6]

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