Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMXZ84M)

Drug Name

Malathion Drug Info

Synonyms

Calmathion; Camathion; Carbafos; Carbetovur; Carbetox; Carbofos; Carbophos; Celthion; Chemathion; Cimexan; Cleensheen; Cythion; Dorthion; Emmatos; Ethiolacar; Etiol; Extermathion; Flair; Forthion; Fosfothion; Fosfotion; Fyfanon; Hilthion; Karbofos; Kypfos; Malacide; Malafor; Malagran; Malakill; Malamar; Malaphele; Malaphos; Malasol; Malaspray; Malataf; Malathiazol; Malathione; Malathiozoo; Malathon; Malathyl; Malation; Malatol; Malatox; Maldison; Malmed; Malphos; Maltox; Mercaptothion; Mercaptotion; Moscarda; Oleophosphothion; Organoderm; Ovide; Paladin; Phosphothion; Prioderm; Sadofos; Sadophos; Sumitox; TAK; Taskil; Vetiol; Zithiol; Carbethoxy malathion; Detm ol ma; Detmol MA; Emmatos extra; Lice Rid;Malathion LV Concentrate; Malathion [USP]; Malation [Polish]; Maltox MLT; Mercaptosuccinic acid diethyl ester; Mercaptotion [Spanish]; Ortho Malathion; Siptox I; Vegfru malatox; AC 26691; EL 4049; Experimental insecticide 4049; Fog 3; Fosfotion 550; Hilthion 25wdp; IFO 13140; Latka 4049; Latka 4049 [Czech]; MET86C_SUPELCO; Malamar 50; Malathion 60; Malathion E50; OMS 1; PS86_SUPELCO; SF 60; Sadofos 30; American cyanamid 4,049; Derbac-M; ENT 17,034; Four thousand forty-nine; Insecticide no. 4049; Kop-Thionkypfosmalacide; Kop-thion; Malathion (USP); Malathion (old ID); Ovide (TN); Staeubol-Puder; Suleo-M; TM-4049; Kill-A-Mite; MALATHION, 96%; Malathion-2,3-14C; 8059HC

Indication

Disease Entry	ICD 11	Status	REF
Pediculus capitis infestation	1G00.0	Approved	[1]

Therapeutic Class

Parasympathomimetics

Cross-matching ID

PubChem CID: 4004
ChEBI ID: CHEBI:6651
CAS Number: CAS 121-75-5
TTD Drug ID: DMXZ84M
INTEDE Drug ID: DR1000
ACDINA Drug ID: D01234

Molecule-Related Drug Atlas

Molecule Type:

DTT

DME

DOT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Patented Agent(s)

Investigative Drug(s)

Preclinical Drug(s)

Discontinued Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Acetylcholinesterase (AChE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[6]
Donepezil	DMIYG7Z	Advanced cancer	2A00-2F9Z	Approved	[7]
Galantamine	DMEO794	Alzheimer disease	8A20	Approved	[8]
Huperzine A	DMMAWLU	Alzheimer disease	8A20	Approved	[9]
Neostigmine	DM6T2J3	Myasthenia gravis	8C6Y	Approved	[10]
YM443	DMNZCI1	Functional dyspepsia	DD90.3	Approved	[11]
Ambenonium	DMOP0BL	Myasthenia gravis	8C6Y	Approved	[12]
Demecarium bromide	DMAYEU1	Open-angle glaucoma	9C61	Approved	[13]
Isoflurophate	DMBSK7X	Glaucoma/ocular hypertension	9C61	Approved	[14]
Pyridostigmine	DM8HO1L	Myasthenia gravis	8C6Y	Approved	[15]
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Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[16]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[17]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[18]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[19]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[20]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[21]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[22]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[23]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[24]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[25]
Zolmitriptan	DM1IB4Q	Migraine	8A80	Approved	[36]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[36]
Etoricoxib	DM6A4NW	Rheumatoid arthritis	FA20	Approved	[36]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[37]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[38]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[39]
Nifedipine	DMSVOZT	Angina pectoris	BA40	Approved	[40]
Zileuton	DMVRIC2	Allergic asthma	CA23.0	Approved	[41]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[42]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[43]
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Drug(s) Metabolized By Cytochrome P450 2B6 (CYP2B6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[26]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[27]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[28]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[31]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[32]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[33]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[34]
Amitriptyline	DMK7F9S	Depression	6A70-6A7Z	Approved	[35]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[44]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[45]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[46]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[47]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[48]
Clopidogrel	DMOL54H	Acute coronary syndrome	BA41	Approved	[49]
Artemisinin	DMOY7W3	Malaria	1F40-1F45	Approved	[50]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[51]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[52]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[53]
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Drug(s) Affected By Mitotic checkpoint serine/threonine-protein kinase BUB1 (BUB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[54]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[55]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[59]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
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Drug(s) Affected By Tissue-type plasminogen activator (PLAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[63]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[64]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[65]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[66]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[67]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[68]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[69]
Fructose	DM43AN2	Vomiting	MD90	Approved	[70]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
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Drug(s) Affected By Replication factor C subunit 3 (RFC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[54]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[59]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[75]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[76]
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Drug(s) Affected By Centromere protein F (CENPF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[77]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[59]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
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Drug(s) Affected By Aldo-keto reductase family 1 member C2 (AKR1C2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[80]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[81]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[82]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[83]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[80]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[84]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[80]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[85]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[86]
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Drug(s) Affected By Aldo-keto reductase family 1 member C1 (AKR1C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[87]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[80]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[81]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[88]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[80]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[80]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[89]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[90]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[88]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[80]
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Drug(s) Affected By Cholinesterase (BCHE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[91]
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[92]
Galantamine	DMEO794	Alzheimer disease	8A20	Approved	[93]
Rivastigmine	DMG629M	Alzheimer disease	8A20	Approved	[94]
Donepezil	DMIYG7Z	Advanced cancer	2A00-2F9Z	Approved	[43]
Succinylcholine	DM2ET1M	Plasma cell myeloma	2A83.1	Approved	[95]
Ethopropazine	DM0N3L7	Parkinson disease	8A00.0	Approved	[92]
Dimenhydrinate	DM264B3	Meniere disease	AB31.0	Approved	[96]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[97]
Chlorpheniramine	DM5URA2	Allergic rhinitis	CA08.0	Approved	[96]
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Drug(s) Affected By Cell division cycle protein 20 homolog (CDC20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[54]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[55]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[98]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[59]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[99]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
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Drug(s) Affected By Acetylcholinesterase (ACHE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetylcholine	DMDF79Z	Cataract	9B10	Approved	[100]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[101]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[102]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[103]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[104]
L-Glutamic Acid	DM4PUDW	Schizophrenia	6A20	Approved	[102]
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[105]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[106]
Neostigmine	DM6T2J3	Myasthenia gravis	8C6Y	Approved	[107]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[86]
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Drug(s) Affected By Cytochrome P450 2C9 (CYP2C9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[108]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[109]
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[110]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[111]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[37]
Zafirlukast	DMHNQOG	Asthma	CA23	Approved	[112]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[110]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[113]
Fluconazole	DMOWZ6B	Cryptococcal meningitis		Approved	[111]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[110]
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Drug(s) Affected By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[114]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[108]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[115]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[111]
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[110]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[116]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[117]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[118]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[119]
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Drug(s) Affected By Cytochrome P450 2A6 (CYP2A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tegafur	DM31ZQM	Solid tumour/cancer	2A00-2F9Z	Approved	[120]
Methoxsalen	DME8FZ9	Cutaneous T-cell lymphoma	2B01	Approved	[121]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[122]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[123]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[124]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[125]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[127]
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[128]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[129]
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Drug(s) Affected By Nuclear receptor subfamily 1 group I member 3 (NR1I3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[130]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[131]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[132]
Artemether	DM48QOT	Malaria	1F40-1F45	Approved	[133]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[135]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[136]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[137]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[138]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
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Drug(s) Affected By Cytochrome P450 2E1 (CYP2E1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fomepizole	DM6VOWQ	Athylene glycol or methanol poisoning	NE61	Approved	[139]
Ademetionine	DMYQDBO	Hepatic fibrosis	DB93.0	Approved	[140]
Theophylline	DMRJFN9	Bronchitis	CA20	Approved	[43]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[141]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[142]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[124]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Didanosine	DMI2QPE	Human immunodeficiency virus infection	1C62	Approved	[43]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[145]
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Drug(s) Affected By Catalase (CAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[146]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[147]
Haloperidol	DM96SE0	Delirium		Approved	[43]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[148]
Selenium	DM25CGV	N. A.	N. A.	Approved	[149]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[150]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[151]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[152]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[153]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
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Drug(s) Affected By G2/mitotic-specific cyclin-B1 (CCNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[54]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[154]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[155]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[77]
Selenium	DM25CGV	N. A.	N. A.	Approved	[156]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[157]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[158]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[159]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[160]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]
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Drug(s) Affected By Cyclin-A2 (CCNA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[161]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[154]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[162]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[82]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[163]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[164]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[89]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[165]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
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⏷ Show the Full List of 10 Drug(s)

Drug(s) Affected By G1/S-specific cyclin-E1 (CCNE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[166]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[167]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[163]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[158]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[164]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[168]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[169]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[170]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[171]
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⏷ Show the Full List of 10 Drug(s)

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[172]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[173]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[174]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[175]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[176]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[177]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[178]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[179]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[180]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[181]
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Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[182]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[183]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[166]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[184]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[185]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[186]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[187]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[188]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[189]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[190]
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Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[191]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[181]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[166]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[192]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[193]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[185]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[194]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[98]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[195]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[158]
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Drug(s) Affected By Shootin-1 (SHTN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[196]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[197]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[75]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[198]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[199]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[200]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[4]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[201]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[202]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[203]
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Drug(s) Affected By Protein shisa-3 homolog (SHISA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[204]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[205]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[206]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[206]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[207]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[4]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[208]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
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Drug(s) Affected By Odontogenic ameloblast-associated protein (ODAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[210]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[198]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[211]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[200]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[212]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[213]
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⏷ Show the Full List of 10 Drug(s)

Drug(s) Affected By ADP-ribose glycohydrolase MACROD2 (MACROD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[214]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[215]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[216]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[208]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[214]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[217]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[218]
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Drug(s) Affected By Myosin-binding protein H-like (MYBPHL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[208]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[213]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[217]
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Drug(s) Affected By Geminin coiled-coil domain-containing protein 1 (GMNC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
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Drug(s) Affected By Pleckstrin homology domain-containing family D member 1 (PLEKHD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[219]
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Drug(s) Affected By Calpain-8 (CAPN8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[220]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[216]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[4]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[221]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
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Drug(s) Affected By Elongin BC and Polycomb repressive complex 2-associated protein (EPOP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[223]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[224]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[225]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[226]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[227]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[228]
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Drug(s) Affected By EF-hand calcium-binding domain-containing protein 9 (EFCAB9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[207]
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Drug(s) Affected By Olfactory receptor 11H12 (OR11H12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[229]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
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Drug(s) Affected By Transmembrane protein 114 (TMEM114)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[230]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
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Drug(s) Affected By Protein shisa-9 (SHISA9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[231]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[207]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[232]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
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Drug(s) Affected By Putative SEC14-like protein 6 (SEC14L6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
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Drug(s) Affected By Uncharacterized membrane protein C3orf80 (C3ORF80)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[233]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[234]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[225]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[208]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[235]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
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Drug(s) Affected By Homeobox protein Meis1 (MEIS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[193]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[193]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[230]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[193]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[207]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[216]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[225]
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Drug(s) Affected By Nuclear factor 1 B-type (NFIB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[214]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[198]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[237]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[238]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[199]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[239]
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Drug(s) Affected By Suppressor of cytokine signaling 3 (SOCS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[240]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[77]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[103]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[241]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[242]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Fedratinib	DM4ZBK6	Myelofibrosis	2A20.2	Approved	[243]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[214]
Pyrimethamine	DM5X7VY	Malaria	1F40-1F45	Approved	[243]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[242]
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Drug(s) Affected By C-X-C motif chemokine 11 (CXCL11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[152]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[244]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[245]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[228]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[246]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[246]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[213]
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⏷ Show the Full List of 10 Drug(s)

Drug(s) Affected By Segment polarity protein dishevelled homolog DVL-1 (DVL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[247]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[248]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[234]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[249]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[200]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[250]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[251]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[247]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[252]
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Drug(s) Affected By RIMS-binding protein 2 (RIMBP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[233]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[207]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[253]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[254]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[218]
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Drug(s) Affected By 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial (CYP27B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcidiol	DMN4CV5	Hypophosphatemia		Approved	[255]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[256]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[230]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[257]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[258]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[259]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[260]
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Drug(s) Affected By Retinoschisin (RS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[261]
Ximelegatran	DMU8ANS	Myocardial infarction	BA41-BA43	Approved	[261]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[262]
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Drug(s) Affected By Interleukin-1 receptor-associated kinase-like 2 (IRAK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[263]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[59]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[244]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[228]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[264]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[265]
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Drug(s) Affected By Aquaporin-9 (AQP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[264]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[266]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[228]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[264]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[267]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[268]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[269]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[199]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[266]
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⏷ Show the Full List of 10 Drug(s)

Drug(s) Affected By Unconventional myosin-Ib (MYO1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[270]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[271]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[75]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[272]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[258]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[198]
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Drug(s) Affected By Growth arrest-specific protein 2 (GAS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[273]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[198]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[199]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[73]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[226]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[213]
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Drug(s) Affected By Perilipin-1 (PLIN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[86]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[264]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[264]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[274]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[275]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[276]
OLEIC ACID	DM54O1Z	Discovery agent	N.A.	Investigative	[277]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[278]
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Drug(s) Affected By Tudor domain-containing protein 6 (TDRD6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[4]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[73]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[219]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[218]
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Drug(s) Affected By Serine protease inhibitor Kazal-type 4 (SPINK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[279]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[280]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[281]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[282]
Octanal	DMTN0OK	N. A.	N. A.	Investigative	[283]
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Drug(s) Affected By Heat shock factor 2-binding protein (HSF2BP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[234]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[213]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[284]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[217]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[285]
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Drug(s) Affected By Low-density lipoprotein receptor-related protein 3 (LRP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[219]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[205]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[230]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[198]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[234]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[200]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
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Drug(s) Affected By Disintegrin and metalloproteinase domain-containing protein 11 (ADAM11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[198]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[221]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[217]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[278]
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Drug(s) Affected By Rab11 family-interacting protein 3 (RAB11FIP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[220]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[228]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[230]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[198]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[234]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[207]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[199]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[202]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
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Drug(s) Affected By NADH dehydrogenase iron-sulfur protein 7, mitochondrial (NDUFS7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[286]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[226]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[75]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[248]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[287]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[219]
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Drug(s) Affected By Olfactory receptor 4F21 (OR4F21)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[288]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[217]
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Drug(s) Affected By Tumor necrosis factor ligand superfamily member 15 (TNFSF15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[67]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[289]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[290]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[291]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[205]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[292]
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Drug(s) Affected By Netrin-1 (NTN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[205]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[234]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[216]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[200]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[208]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[217]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[218]
BADGE	DMCK5DG	Discovery agent	N.A.	Investigative	[293]
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Drug(s) Affected By Cholesterol 25-hydroxylase (CH25H)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[219]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[279]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[294]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[274]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[295]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[296]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[219]
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Drug(s) Affected By Urokinase-type plasminogen activator (PLAU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[297]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[103]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[298]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[59]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[297]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[214]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[299]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[300]
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Drug(s) Affected By Complement factor B (CFB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[59]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[301]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[302]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[264]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[205]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[230]
Danazol	DML8KTN	Menorrhagia	GA20.50	Approved	[303]
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Drug(s) Affected By GTPase HRas (HRAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[304]
Selenium	DM25CGV	N. A.	N. A.	Approved	[305]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[306]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[307]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[263]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[308]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[309]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[310]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[223]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[311]
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Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[312]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[313]
Fructose	DM43AN2	Vomiting	MD90	Approved	[43]
Ketoprofen	DMRKXPT	Bursitis		Approved	[43]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[314]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[315]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[316]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[317]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[318]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[319]
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Drug(s) Affected By Interferon alpha-2 (IFNA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[320]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[216]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[320]
PF-3758309	DM36PKZ	Solid tumour/cancer	2A00-2F9Z	Phase 1	[321]
BIX-01294	DM5CBNY	Breast cancer	2C60-2C65	Preclinical	[322]
UNC0638	DM4A1KJ	Discovery agent	N.A.	Investigative	[322]
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Drug(s) Affected By Interleukin-1 alpha (IL1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[166]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[323]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[323]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[319]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[323]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[152]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[324]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[323]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[325]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
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Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[326]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[327]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[328]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[323]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[146]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[323]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[329]
Selenium	DM25CGV	N. A.	N. A.	Approved	[330]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[331]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[332]
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Drug(s) Affected By Keratin, type I cytoskeletal 14 (KRT14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[333]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[71]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[334]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[335]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[75]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[336]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[71]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[337]
Methamphetamine	DMPM4SK	Anxiety		Approved	[338]
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Drug(s) Affected By Fibrinogen gamma chain (FGG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[82]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[339]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[340]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[341]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[342]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[198]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[343]
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Drug(s) Affected By Myelin basic protein (MBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[152]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[344]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[86]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[218]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[341]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[75]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[290]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[274]
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Drug(s) Affected By Transferrin receptor protein 1 (TFRC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[155]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[345]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[346]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[347]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[242]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[286]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[348]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[349]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[350]
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Drug(s) Affected By Metallothionein-2 (MT2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[351]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[166]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[82]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[352]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[353]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[325]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[348]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[354]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[355]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[356]
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Drug(s) Affected By Estrogen receptor (ESR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[357]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[358]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[359]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[360]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[361]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[362]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[363]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[364]
Procaine	DM4LSNE	Anaesthesia	9A78.6	Approved	[360]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[365]
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Drug(s) Affected By Interstitial collagenase (MMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[54]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[366]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[367]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[368]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[67]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[369]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[370]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[69]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[371]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[372]
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Drug(s) Affected By Granulocyte-macrophage colony-stimulating factor (CSF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[373]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[374]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[325]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[375]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[376]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[377]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[86]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[378]
Acetylcholine	DMDF79Z	Cataract	9B10	Approved	[379]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[380]
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Drug(s) Affected By HLA class I histocompatibility antigen, A alpha chain (HLA-A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[381]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[382]
Allopurinol	DMLPAOB	Gout	FA25	Approved	[383]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[384]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[385]
Ticlopidine	DMO946V	Acute coronary syndrome	BA41	Approved	[386]
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[385]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[387]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[387]
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Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[388]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[152]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[389]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[390]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[175]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[391]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[392]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[393]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[394]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[395]
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Drug(s) Affected By Metallothionein-1E (MT1E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[396]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[348]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[397]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[398]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[399]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[230]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[400]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[401]
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Drug(s) Affected By Guanine nucleotide-binding protein G(i) subunit alpha-2 (GNAI2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[305]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[223]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[402]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[75]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[403]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[234]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[211]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[200]
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Drug(s) Affected By Plasminogen activator inhibitor 2 (SERPINB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[166]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[327]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[71]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[404]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[405]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[355]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[244]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
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Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[406]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[407]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[166]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[408]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[409]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[327]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[319]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[329]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[410]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[406]
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Drug(s) Affected By Endothelin-1 (EDN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[411]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[220]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[412]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[67]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[413]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[414]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[247]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[415]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[416]
Lisinopril	DMUOK4C	Chronic heart failure	BD1Z	Approved	[417]
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Drug(s) Affected By Neuroendocrine protein 7B2 (SCG5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[279]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[205]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[230]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[418]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[234]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[124]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[226]
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Drug(s) Affected By T-cell surface glycoprotein CD5 (CD5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[220]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Bortezomib	DMNO38U	Leukemia		Approved	[419]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[420]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[221]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
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Drug(s) Affected By Metallothionein-1B (MT1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[354]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[421]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[422]
Promegestone	DMK4S8I	Gynecological disease	GA6Z	Approved	[423]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[274]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[424]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[77]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[425]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[426]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[427]
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Drug(s) Affected By Decorin (DCN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[319]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[428]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[59]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[233]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[86]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[244]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[429]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[430]
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Drug(s) Affected By Profilin-1 (PFN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[288]
Selenium	DM25CGV	N. A.	N. A.	Approved	[305]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[431]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[432]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[433]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[434]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[435]
Haloperidol	DM96SE0	Delirium		Approved	[436]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[437]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[75]
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Drug(s) Affected By Pulmonary surfactant-associated protein B (SFTPB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[152]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[438]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Terbutaline	DMD4381	Asthma	CA23	Approved	[439]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[439]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[440]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[441]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[440]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[440]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[4]
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Drug(s) Affected By Collagen alpha-2(I) chain (COL1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[214]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[196]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[442]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[443]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[444]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[445]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[75]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[274]
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Drug(s) Affected By Stromelysin-1 (MMP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[43]
Fluvastatin	DM4MDJY	Arteriosclerosis	BD40	Approved	[43]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[43]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[43]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[326]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[63]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[368]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[446]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[447]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[69]
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Drug(s) Affected By Inhibin beta A chain (INHBA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[196]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[279]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[244]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[448]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[449]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[274]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[450]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[275]
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Drug(s) Affected By Monocyte differentiation antigen CD14 (CD14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[451]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[263]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[59]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[452]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[354]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[453]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[454]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[455]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
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Drug(s) Affected By Hepatocyte growth factor receptor (MET)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cabozantinib	DMIYDT4	Medullary thyroid gland carcinoma		Approved	[456]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[457]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[323]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[323]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[323]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[406]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[323]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[458]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[406]
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Drug(s) Affected By Alpha-2A adrenergic receptor (ADRA2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[211]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[43]
Rilmenidine	DM13PQW	Hypertension	BA00-BA04	Approved	[459]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[286]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[233]
Oxymetazoline	DM8ZXT6	Arrhythmia	BC9Z	Approved	[460]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[220]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Indapamide	DMGN1PW	Edema	MG29	Approved	[461]
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Drug(s) Affected By Glutathione S-transferase P (GSTP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[462]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[234]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[463]
Chlorambucil	DMRKE63	Chronic lymphocytic leukaemia	2A82.0	Approved	[463]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[464]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[465]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[98]
Selenium	DM25CGV	N. A.	N. A.	Approved	[305]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[431]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[466]
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Drug(s) Affected By Stromelysin-2 (MMP10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[73]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[166]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[406]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[89]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[406]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[71]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[294]
Haloperidol	DM96SE0	Delirium		Approved	[436]
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Drug(s) Affected By Galectin-1 (LGALS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[240]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[433]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[467]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[196]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[468]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[435]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[469]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[220]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[437]
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Drug(s) Affected By Granulocyte colony-stimulating factor (CSF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[166]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[327]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[63]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[470]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[471]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[376]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[472]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[400]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[406]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[473]
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Drug(s) Affected By Myocardial zonula adherens protein (MYZAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[305]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[103]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[286]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[474]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[233]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[220]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[475]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[199]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[200]
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Drug(s) Affected By Coiled-coil domain-containing protein 192 (CCDC192)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[476]
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Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[477]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[478]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[479]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[408]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[480]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[327]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[323]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[146]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[481]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[323]
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Drug(s) Affected By C-C motif chemokine 3 (CCL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[409]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[152]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[325]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[482]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[433]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[483]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[484]
Betamethasone	DMAHJEF	Acute adrenal insufficiency		Approved	[485]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[485]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[409]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[191]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[486]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[487]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[488]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[43]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[166]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[192]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[184]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[315]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[489]
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Drug(s) Affected By Platelet factor 4 variant (PF4V1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[220]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[218]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[284]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[218]
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Drug(s) Affected By Retinol-binding protein 3 (RBP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[216]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[208]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
MG-132	DMKA2YS	N. A.	N. A.	Preclinical	[490]
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Drug(s) Affected By Fibroblast growth factor 6 (FGF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[491]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[220]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[292]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[492]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
AMINOHIPPURIC ACID	DMUN54G	Discovery agent	N.A.	Investigative	[493]
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Drug(s) Affected By Fibroblast growth factor receptor 1 (FGFR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[98]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[247]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[286]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[494]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[372]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[495]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[495]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[442]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[223]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
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Drug(s) Affected By Proliferating cell nuclear antigen (PCNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[166]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[162]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[270]
Selenium	DM25CGV	N. A.	N. A.	Approved	[156]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[496]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[163]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[195]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[67]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[89]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[497]
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Drug(s) Affected By Nucleoprotein TPR (TPR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[288]
Selenium	DM25CGV	N. A.	N. A.	Approved	[305]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[498]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[247]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[499]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[445]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[75]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[436]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[436]
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Drug(s) Affected By Tissue factor (F3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[500]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[501]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[502]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[503]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[504]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[505]
Fructose	DM43AN2	Vomiting	MD90	Approved	[70]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[506]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[501]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[467]
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Drug(s) Affected By HLA class I histocompatibility antigen, alpha chain E (HLA-E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[387]
Clindamycin	DM15HL8	Acne vulgaris	ED80	Approved	[387]
Selenium	DM25CGV	N. A.	N. A.	Approved	[305]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[387]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[387]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[247]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[286]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[483]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[387]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[86]
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Drug(s) Affected By Plastin-3 (PLS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[77]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[86]
Haloperidol	DM96SE0	Delirium		Approved	[436]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[75]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[436]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[507]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[199]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[226]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[508]
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Drug(s) Affected By Indoleamine 2,3-dioxygenase 1 (IDO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-Tryptophan	DMIBH7M	Depression	6A70-6A7Z	Approved	[509]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[510]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[511]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[512]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[445]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[226]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[205]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[230]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[206]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[234]
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Drug(s) Affected By Leukemia inhibitory factor (LIF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[166]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[82]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[67]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[59]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[301]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[513]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[294]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[220]
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Drug(s) Affected By Beta-1,4-galactosyltransferase 1 (B4GALT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[405]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[244]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[228]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[75]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[274]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[514]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[514]
Estriol	DMOEM2I	Hormone deficiency	5A61.1	Approved	[514]
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Drug(s) Affected By Paired box protein Pax-1 (PAX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[207]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[211]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[278]
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Drug(s) Affected By Desmoplakin (DSP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[334]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[294]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[442]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[437]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[198]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[515]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[200]
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Drug(s) Affected By Ankyrin-1 (ANK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[445]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[226]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[516]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[234]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[207]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[517]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[226]
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Drug(s) Affected By C-C motif chemokine 3-like 1 (CCL3L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[330]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[152]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[396]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[205]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[518]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[519]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[520]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[521]
EUGENOL	DM7US1H	Discovery agent	N.A.	Patented	[522]
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Drug(s) Affected By Platelet glycoprotein 4 (CD36)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[523]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[524]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[525]
Tolcapone	DM8MNVO	Parkinson disease	8A00.0	Approved	[526]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[527]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[223]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[528]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[127]
Asasantin	DMCZIHT	Cerebrovascular ischaemia	8B1Z	Approved	[529]
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Drug(s) Affected By Complement receptor type 1 (CR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[530]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[103]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[218]
Josamycin	DMKJ8LB	Bacterial infection	1A00-1C4Z	Approved	[531]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[216]
Ardeparin	DMYRX8B	Deep vein thrombosis	BD71	Approved	[532]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[219]
Maleic Acid	DM4L0R7	Discovery agent	N.A.	Investigative	[533]
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Drug(s) Affected By Histidine decarboxylase (HDC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[534]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[169]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[535]
Nilotinib	DM7HXWT	Chronic myelogenous leukaemia	2A20.0	Approved	[536]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[536]
Isoflurophate	DMBSK7X	Glaucoma/ocular hypertension	9C61	Approved	[537]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[214]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[538]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
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Drug(s) Affected By Elafin (PI3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[264]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[279]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[205]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[539]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[216]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[426]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[200]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[201]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
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Drug(s) Affected By Aromatic-L-amino-acid decarboxylase (DDC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levodopa	DMN3E57	Parkinson disease	8A00.0	Approved	[540]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[286]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Isoflurophate	DMBSK7X	Glaucoma/ocular hypertension	9C61	Approved	[537]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[226]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[210]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[198]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[541]
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Drug(s) Affected By Interleukin-11 (IL11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[63]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[59]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[542]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[294]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[543]
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Drug(s) Affected By Cytochrome P450 3A5 (CYP3A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[114]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[108]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[117]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[117]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[544]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[545]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[546]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[547]
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Drug(s) Affected By C-C motif chemokine 1 (CCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[548]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[228]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[290]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[549]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[550]
ACYLINE	DM9GRTK	Prostate cancer	2C82.0	Phase 2	[551]
ANW-32821	DMMJOZD	N. A.	N. A.	Phase 2	[552]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[553]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[554]
Nickel chloride	DMI12Y8	Discovery agent	N.A.	Investigative	[555]
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Drug(s) Affected By Nuclear receptor subfamily 4immunitygroup A member 1 (NR4A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[556]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[82]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[339]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[196]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[557]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Febuxostat	DMDEXQ0	Hyperuricaemia	5C55.Y	Approved	[558]
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Drug(s) Affected By Vitamin K-dependent protein Z (PROZ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[223]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[264]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[198]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[234]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[207]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[4]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[559]
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Drug(s) Affected By Protein S100-A1 (S100A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[270]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[71]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[223]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[560]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[71]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[198]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[234]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[249]
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Drug(s) Affected By Oligodendrocyte-myelin glycoprotein (OMG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[561]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[562]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[294]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[562]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[220]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[563]
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Drug(s) Affected By Brain-derived neurotrophic factor (BDNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Haloperidol	DM96SE0	Delirium		Approved	[564]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[240]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[565]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Bupivacaine	DM4PRFC	Anaesthesia	9A78.6	Approved	[566]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[567]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[294]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[244]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[220]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
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Drug(s) Affected By Follicle-stimulating hormone receptor (FSHR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[568]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[568]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[568]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[569]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[570]
MICROCYSTIN-LR	DMTMLRN	Discovery agent	N.A.	Investigative	[571]
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Drug(s) Affected By Chymase (CMA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[284]
paraquat	DMR8O3X	Discovery agent	N.A.	Investigative	[572]
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Drug(s) Affected By Cytochrome P450 3A7 (CYP3A7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[545]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[573]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[574]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[575]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[53]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[576]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[577]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[263]
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Drug(s) Affected By Endothelin receptor type B (EDNRB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[561]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[578]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[214]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[233]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[445]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[197]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[579]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[449]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[580]
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Drug(s) Affected By Cyclin-dependent kinase 2 (CDK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[54]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[154]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[167]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[581]
Selenium	DM25CGV	N. A.	N. A.	Approved	[156]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[158]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[582]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[583]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[584]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[585]
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Drug(s) Affected By Integrin beta-8 (ITGB8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[67]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[442]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[228]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[230]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[426]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[586]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[200]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[444]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[202]
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Drug(s) Affected By Dual specificity protein phosphatase 1 (DUSP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[166]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[451]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[587]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[588]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[589]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[301]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[494]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[557]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[294]
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Drug(s) Affected By SHC-transforming protein 1 (SHC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[590]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[354]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[591]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[75]
Bortezomib	DMNO38U	Leukemia		Approved	[592]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[198]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[593]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[199]
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Drug(s) Affected By Protein PML (PML)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[305]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[594]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[242]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[301]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[242]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[75]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[291]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[595]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[595]
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Drug(s) Affected By Phosphatidylethanolamine-binding protein 1 (PEBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[596]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[597]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[75]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[436]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[436]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[198]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[598]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[260]
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Drug(s) Affected By Somatostatin receptor type 2 (SSTR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pasireotide	DMHM7JS	Cushing disease	5A70	Approved	[599]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[233]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[422]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[4]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[214]
Edotreotide	DMQ08AJ	Acromegaly	5A60.0	Phase 2	[600]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
PMID26394986-Compound-22	DM43Z1G	N. A.	N. A.	Patented	[601]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[228]
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Drug(s) Affected By Guanylate-binding protein 1 (GBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[193]
Selenium	DM25CGV	N. A.	N. A.	Approved	[305]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[406]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[339]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[406]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[445]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[226]
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Drug(s) Affected By Interleukin-13 (IL13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[602]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[603]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[604]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[471]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[605]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[606]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Budesonide	DMJIBAW	Allergic rhinitis	CA08.0	Approved	[607]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[471]
Ethambutol	DMR87LC	Pulmonary tuberculosis	1B10.Z	Approved	[605]
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Drug(s) Affected By Polycomb complex protein BMI-1 (BMI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Ibrutinib	DMHZCPO	Mantle cell lymphoma	2A85.5	Approved	[608]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[609]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[230]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[610]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[234]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[207]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[199]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[611]
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Drug(s) Affected By Prohibitin 1 (PHB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[436]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[98]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[562]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[612]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[613]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[562]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[127]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[75]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[614]
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Drug(s) Affected By Pro-adrenomedullin (ADM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[615]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[616]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[152]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[592]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[220]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[617]
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Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[618]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[619]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[620]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[621]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[622]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[623]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[624]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[240]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[323]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[625]
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Drug(s) Affected By Vascular endothelial growth factor receptor 3 (FLT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[626]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[627]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[231]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[628]
PMID25656651-Compound-5	DMAI95U	Chronic myeloid leukaemia	2A20	Patented	[629]
Scriptaid	DM9JZ21	Solid tumour/cancer	2A00-2F9Z	Preclinical	[630]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[631]
Nitrobenzanthrone	DMN6L70	N. A.	N. A.	Investigative	[632]
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Drug(s) Affected By Macrophage metalloelastase (MMP12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[406]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[89]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[406]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[483]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[406]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[198]
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Drug(s) Affected By Platelet glycoprotein V (GP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[633]
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Drug(s) Affected By Transcription factor ETV6 (ETV6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[75]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[634]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[198]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[635]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[237]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[199]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[202]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[634]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[636]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[637]
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Drug(s) Affected By C-X-C motif chemokine 5 (CXCL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[54]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[63]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[214]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[354]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[86]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[290]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[449]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[205]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[638]
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Drug(s) Affected By Transcription factor GATA-4 (GATA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[639]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[640]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[214]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[641]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[642]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[643]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[644]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[207]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[200]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[4]
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Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[305]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[103]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[263]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[308]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[645]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[75]
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Drug(s) Affected By Tissue factor pathway inhibitor 2 (TFPI2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[214]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[294]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[86]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[75]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[205]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[230]
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Drug(s) Affected By Caspase-4 (CASP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[326]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[451]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[155]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[77]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[646]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[647]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[648]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[86]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[649]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[244]
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Drug(s) Affected By DNA replication licensing factor MCM2 (MCM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[166]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[324]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[59]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[301]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[289]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[421]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[75]
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Drug(s) Affected By Type I iodothyronine deiodinase (DIO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[650]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[474]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[226]
Ergocalciferol	DMHO0AR	Hypoparathyroidism	5A50	Approved	[651]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[652]
Masoprocol	DMMVNZ0	Prostate cancer	2C82.0	Approved	[651]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[210]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[653]
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Drug(s) Affected By Histamine N-methyltransferase (HNMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[654]
Selenium	DM25CGV	N. A.	N. A.	Approved	[305]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[214]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[86]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[198]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[77]
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Drug(s) Affected By Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' (PDE6C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[225]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[575]
Methamphetamine	DMPM4SK	Anxiety		Approved	[655]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[228]
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Drug(s) Affected By Interleukin-1 receptor-associated kinase 1 (IRAK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[77]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[67]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[324]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[263]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[656]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[657]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[75]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[658]
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Drug(s) Affected By AF4/FMR2 family member 1 (AFF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[77]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[223]
Bortezomib	DMNO38U	Leukemia		Approved	[419]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[198]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[231]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[659]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[200]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[660]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
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Drug(s) Affected By CCAAT/enhancer-binding protein gamma (CEBPG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[77]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[247]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[294]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[226]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[661]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[198]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[231]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[662]
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Drug(s) Affected By Cysteine-rich secretory protein 3 (CRISP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[242]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[475]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[272]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[275]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[663]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[272]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
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Drug(s) Affected By Ephrin type-A receptor 4 (EPHA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[664]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[665]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[214]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[664]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[294]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[86]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Mestranol	DMG3F94	Contraception	QA21	Approved	[664]
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Drug(s) Affected By GTP-binding protein RAD (RRAD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[279]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[244]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[445]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[228]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[666]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[230]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[258]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[198]
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Drug(s) Affected By Claudin-12 (CLDN12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[59]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[220]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[230]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[198]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[211]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[200]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[250]
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Drug(s) Affected By A disintegrin and metalloproteinase with thrombospondin motifs 12 (ADAMTS12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[450]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[211]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[200]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[208]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[559]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[217]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[219]
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Drug(s) Affected By A disintegrin and metalloproteinase with thrombospondin motifs 20 (ADAMTS20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[667]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[244]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[475]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[124]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[668]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[669]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[202]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[218]
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Drug(s) Affected By Myelin proteolipid protein (PLP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[214]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[233]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[218]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[75]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[224]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[670]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[4]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[212]
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Drug(s) Affected By Somatostatin (SST)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[214]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[429]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
Octreotide	DMHIDCJ	Acromegaly	5A60.0	Approved	[671]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[274]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[198]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[672]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[82]
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Drug(s) Affected By Protein BTG1 (BTG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[673]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[562]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[674]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[434]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[468]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[562]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[223]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[228]
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Drug(s) Affected By Guanine nucleotide-binding protein G(i) subunit alpha-1 (GNAI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[75]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[198]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[56]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[199]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[213]
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Drug(s) Affected By Pituitary homeobox 1 (PITX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[305]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[230]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[234]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[295]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[675]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[212]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[208]
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Drug(s) Affected By Reelin (RELN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[219]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[676]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[214]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[223]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[75]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[677]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[198]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[216]
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Drug(s) Affected By C-C motif chemokine 20 (CCL20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[166]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[327]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[63]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[406]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[59]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[548]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[406]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[244]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[678]
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Drug(s) Affected By C-C motif chemokine 7 (CCL7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[63]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[548]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[548]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Isoproterenol	DMK7MEY	Atrioventricular block		Approved	[679]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[200]
Abexinostat	DM91LGU	Follicular lymphoma	2A80	Phase 3	[680]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[284]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[681]
Nickel chloride	DMI12Y8	Discovery agent	N.A.	Investigative	[555]
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Drug(s) Affected By Serine protease HTRA4 (HTRA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[682]
L-serine	DM6WPIS	Pulmonary tuberculosis	1B10.Z	Investigative	[683]
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Drug(s) Affected By Tumor necrosis factor-inducible gene 6 protein (TNFAIP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[63]
Selenium	DM25CGV	N. A.	N. A.	Approved	[330]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[323]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[59]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[483]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[323]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[323]
Trihexyphenidyl	DMB19L8	Dystonia	8A02	Approved	[323]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[323]
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Drug(s) Affected By Forkhead box protein O4 (FOXO4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[247]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[223]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[684]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[685]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[686]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[206]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[231]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[225]
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Drug(s) Affected By Runt-related transcription factor 1 (RUNX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[219]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[59]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[247]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[244]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[356]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[356]
Cotinine	DMCEZ1B	Insecticide	N.A.	Approved	[687]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
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Drug(s) Affected By Angiopoietin-1 receptor (TEK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[688]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[688]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[689]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[690]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[449]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[216]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[200]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[212]
Rigosertib	DMOSTXF	Myelodysplastic syndrome	2A37	Phase 3	[691]
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⏷ Show the Full List of 10 Drug(s)

Drug(s) Affected By Histone-lysine N-methyltransferase 2A (KMT2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[692]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[693]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[294]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[445]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[694]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[695]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[696]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[198]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[231]
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Drug(s) Affected By Urokinase plasminogen activator surface receptor (PLAUR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[664]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[697]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[298]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[698]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[372]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[699]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[700]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
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Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[326]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[489]
Selenium	DM25CGV	N. A.	N. A.	Approved	[305]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[594]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[701]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[702]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[703]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[247]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[704]
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Drug(s) Affected By Keratin, type I cytoskeletal 17 (KRT17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[705]
Selenium	DM25CGV	N. A.	N. A.	Approved	[305]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[89]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[71]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[705]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[223]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[71]
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Drug(s) Affected By Glutamate decarboxylase 2 (GAD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isoflurophate	DMBSK7X	Glaucoma/ocular hypertension	9C61	Approved	[537]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[207]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[202]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[537]
Chlorphrifos oxon	DMGBT68	Discovery agent	N.A.	Investigative	[537]
CHLORPYRIFOS	DMKPUI6	Discovery agent	N.A.	Investigative	[537]
PARAOXON	DMN4ZKC	Discovery agent	N.A.	Investigative	[537]
Hexadecanoic acid	DMWUXDZ	Discovery agent	N.A.	Investigative	[706]
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Drug(s) Affected By Homeobox protein engrailed-1 (EN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[219]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[643]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[643]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[209]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[211]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[208]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[707]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
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Drug(s) Affected By Early activation antigen CD69 (CD69)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[247]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[708]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[709]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[708]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[708]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[228]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[449]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[205]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[549]
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Drug(s) Affected By Epithelial discoidin domain-containing receptor 1 (DDR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[442]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[220]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[205]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[684]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[710]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[644]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[200]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[644]
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Drug(s) Affected By Calcium-activated potassium channel subunit alpha-1 (KCNMA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[219]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[103]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[196]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[230]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[215]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[237]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[207]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[711]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[295]
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Drug(s) Affected By Interleukin-24 (IL24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[166]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[323]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[327]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[323]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[323]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[712]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[59]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[323]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[71]
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Drug(s) Affected By Protein disulfide-isomerase A2 (PDIA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[494]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[234]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[713]
Vitamin C	DMXJ7O8	Adenocarcinoma	2D40	Approved	[714]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[208]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[715]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[284]
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⏷ Show the Full List of 9 Drug(s)

Drug(s) Affected By G protein pathway suppressor 2 (GPS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[223]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[716]
Z-Pro-Prolinal	DM43O2U	Discovery agent	N.A.	Investigative	[717]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[718]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[719]
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⏷ Show the Full List of 7 Drug(s)

Drug(s) Affected By Urea transporter 1 (SLC14A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[86]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[205]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[258]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[73]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[253]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[575]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[4]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[720]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[721]
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⏷ Show the Full List of 10 Drug(s)

Drug(s) Affected By NAD(P) transhydrogenase, mitochondrial (NNT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[270]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[86]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[75]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[436]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[230]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[198]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[722]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[722]
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Drug(s) Affected By Voltage-dependent L-type calcium channel subunit alpha-1C (CACNA1C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[219]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[103]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[723]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[724]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Retigabine	DMGNYIH	Behcet disease	4A62	Approved	[725]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[76]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[207]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[200]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[726]
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Drug(s) Affected By Core-binding factor subunit beta (CBFB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[615]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[77]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[348]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[294]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[226]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[75]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[348]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[198]
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Drug(s) Affected By Carcinoembryonic antigen-related cell adhesion molecule 7 (CEACAM7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[339]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[205]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[225]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
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Drug(s) Affected By Double C2-like domain-containing protein beta (DOC2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[208]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[637]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
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Drug(s) Affected By Interleukin-27 subunit beta (EBI3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[63]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Epanova	DMHEAGL	Hypertriglyceridemia	5C80.1	Approved	[727]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[205]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[198]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[728]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[234]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[729]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[200]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[214]
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⏷ Show the Full List of 10 Drug(s)

Drug(s) Affected By Fibroblast growth factor-binding protein 1 (FGFBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[77]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[244]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[448]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[205]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[207]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[427]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[730]
Seocalcitol	DMKL9QO	Rickets	5B57	Phase 3	[731]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[221]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
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Drug(s) Affected By Interleukin-13 receptor subunit alpha-2 (IL13RA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[429]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[449]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[205]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[230]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[685]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[450]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[550]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[732]
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⏷ Show the Full List of 10 Drug(s)

Drug(s) Affected By Serine/threonine-protein kinase D1 (PRKD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[234]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[207]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[225]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[200]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[213]
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⏷ Show the Full List of 10 Drug(s)

Drug(s) Affected By 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 (PLCB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[305]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[442]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[234]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[216]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[200]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[202]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[201]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[305]
Sphingosine-1-phosphate	DMJCQKA	Acne vulgaris	ED80	Phase 1	[733]
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⏷ Show the Full List of 10 Drug(s)

Drug(s) Affected By Receptor tyrosine-protein kinase erbB-4 (ERBB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[734]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[86]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[735]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[214]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[400]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[736]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[198]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[635]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[207]
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Drug(s) Affected By Olfactory receptor 4D1 (OR4D1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[211]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[737]
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Drug(s) Affected By Disks large homolog 2 (DLG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[436]
Haloperidol	DM96SE0	Delirium		Approved	[436]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[220]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[422]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[436]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[436]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[343]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[272]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[213]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
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Drug(s) Affected By Rhodopsin kinase GRK1 (GRK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[220]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
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Drug(s) Affected By Sodium channel protein type 9 subunit alpha (SCN9A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[738]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[223]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[197]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[198]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[234]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[124]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[200]
Tetrodotoxin	DMWMPRG	Bacterial infection	1A00-1C4Z	Approved	[739]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[4]
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Drug(s) Affected By Heat shock protein beta-2 (HSPB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[740]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[124]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[741]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[426]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[208]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[742]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[217]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[743]
linalool	DMGZQ5P	Discovery agent	N.A.	Investigative	[744]
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Drug(s) Affected By Cocaine- and amphetamine-regulated transcript protein (CARTPT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[745]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[746]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[202]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
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Drug(s) Affected By BDNF/NT-3 growth factors receptor (NTRK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[319]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[747]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[286]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[233]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[709]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[220]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[748]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[205]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[593]
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Drug(s) Affected By Dual specificity protein phosphatase 5 (DUSP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[166]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[616]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[214]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[749]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[279]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[356]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[244]
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⏷ Show the Full List of 10 Drug(s)

Drug(s) Affected By Plasma membrane calcium-transporting ATPase 3 (ATP2B3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[219]
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Drug(s) Affected By Serine protease inhibitor Kazal-type 13 (SPINK13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[207]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[295]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[284]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[718]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[750]
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⏷ Show the Full List of 7 Drug(s)

Drug(s) Affected By UDP-N-acetylglucosamine transporter TMEM241 (TMEM241)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[230]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[249]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[213]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[217]
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Drug(s) Affected By MHC class I polypeptide-related sequence A (MICA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[751]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[752]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[223]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[753]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[754]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[230]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[206]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[206]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[207]
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Drug(s) Affected By Prospero homeobox protein 2 (PROX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[220]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
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Drug(s) Affected By Acyl-coenzyme A thioesterase 6 (ACOT6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[207]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[755]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
CITCO	DM0N634	Discovery agent	N.A.	Investigative	[756]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[219]
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Drug(s) Affected By Ankyrin repeat domain-containing protein 55 (ANKRD55)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[207]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[213]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[202]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[757]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[219]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[278]
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⏷ Show the Full List of 8 Drug(s)

Drug(s) Affected By Keratin-associated protein 27-1 (KRTAP27-1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[4]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
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Drug(s) Affected By Keratin-associated protein 13-3 (KRTAP13-3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
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Drug(s) Affected By Uncharacterized protein C8orf34 (C8ORF34)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[214]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[244]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[475]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[758]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[214]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[214]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[219]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[218]
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⏷ Show the Full List of 9 Drug(s)

Drug(s) Affected By Protein FAM229B (FAM229B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[223]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[197]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[403]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[202]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[217]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[219]
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⏷ Show the Full List of 8 Drug(s)

Drug(s) Affected By Filamin A-interacting protein 1-like (FILIP1L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[759]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[442]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[223]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[58]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[205]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[507]
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Drug(s) Affected By Angiomotin (AMOT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[233]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[220]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[445]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[224]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[58]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[684]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[230]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[207]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[225]
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⏷ Show the Full List of 10 Drug(s)

Drug(s) Affected By Quinone oxidoreductase PIG3 (TP53I3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[187]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[67]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[760]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[761]
Amifostine	DM5FL14	Mucositis	CA00	Approved	[762]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[86]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[763]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[356]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[356]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[356]
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Drug(s) Affected By Interferon-induced protein 44-like (IFI44L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[406]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[406]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[279]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[86]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[448]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[445]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[214]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[228]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[230]
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Drug(s) Affected By Tumor necrosis factor alpha-induced protein 8-like protein 3 (TNFAIP8L3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[244]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[230]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[200]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[213]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[203]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[563]
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⏷ Show the Full List of 6 Drug(s)

Drug(s) Affected By Cilia- and flagella-associated protein 157 (CFAP157)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[225]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
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Drug(s) Affected By Ephrin type-A receptor 10 (EPHA10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[764]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[220]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[207]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[225]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[4]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[208]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[764]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[278]
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Drug(s) Affected By Sperm protein associated with the nucleus on the X chromosome N3 (SPANXN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[244]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[211]
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Drug(s) Affected By Speedy protein A (SPDYA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[234]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[272]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
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Drug(s) Affected By Trichohyalin-like protein 1 (TCHHL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[219]
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Drug(s) Affected By Late cornified envelope-like proline-rich protein 1 (LELP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[765]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[215]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[211]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
PMID27336223-Compound-5	DM6E50A	N. A.	N. A.	Patented	[765]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[718]
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⏷ Show the Full List of 6 Drug(s)

Drug(s) Affected By Acyl-CoA-binding domain-containing protein 5 (ACBD5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[77]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[75]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[199]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[200]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[4]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[217]
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⏷ Show the Full List of 10 Drug(s)

Drug(s) Affected By Armadillo repeat-containing protein 3 (ARMC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[219]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[225]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[221]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
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Drug(s) Affected By Lysophospholipid acyltransferase LPCAT4 (LPCAT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[75]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[216]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[200]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[202]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[226]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[214]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[217]
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⏷ Show the Full List of 9 Drug(s)

Drug(s) Affected By Carboxypeptidase Z (CPZ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[294]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[442]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[226]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[449]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[211]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[212]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[208]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[737]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[217]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[219]
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Drug(s) Affected By Kazrin (KAZN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[223]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[198]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[450]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[207]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[249]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[201]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[201]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[201]
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⏷ Show the Full List of 10 Drug(s)

Drug(s) Affected By LEM domain-containing protein 1 (LEMD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[279]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[685]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[575]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[226]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[214]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[766]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[221]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[718]
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⏷ Show the Full List of 10 Drug(s)

Drug(s) Affected By GRAM domain-containing protein 4 (GRAMD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[244]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[231]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[207]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[767]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[200]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[73]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[274]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[218]
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⏷ Show the Full List of 10 Drug(s)

Drug(s) Affected By Olfactory receptor 4F3/4F16/4F29 (OR4F16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[288]
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Drug(s) Affected By Pre T-cell antigen receptor alpha (PTCRA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
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Drug(s) Affected By Transmembrane protein 65 (TMEM65)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[530]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[223]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[211]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[768]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[226]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[228]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[769]
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Drug(s) Affected By Probable G-protein coupled receptor 179 (GPR179)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[737]
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Drug(s) Affected By Opsin-5 (OPN5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[219]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[207]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[4]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[219]
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⏷ Show the Full List of 6 Drug(s)

Drug(s) Affected By ALK and LTK ligand 2 (ALKAL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[214]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[220]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[4]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[214]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[73]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[282]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[218]
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⏷ Show the Full List of 10 Drug(s)

Drug(s) Affected By Butyrophilin-like protein 3 (BTNL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[713]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[4]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[221]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
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Drug(s) Affected By R-spondin-2 (RSPO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[214]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[233]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[258]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[211]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[214]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[212]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[214]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[218]
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⏷ Show the Full List of 10 Drug(s)

Drug(s) Affected By Uncharacterized protein C12orf54 (C12ORF54)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[228]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[207]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[228]
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Drug(s) Affected By Kinesin-like protein KIF6 (KIF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[770]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[207]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[211]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[202]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[771]
Rosuvastatin	DMMIQ7G	Arteriosclerosis	BD40	Approved	[771]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[771]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[202]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[262]
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⏷ Show the Full List of 10 Drug(s)

Drug(s) Affected By Protein lin-28 homolog B (LIN28B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[772]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[230]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[773]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[772]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[262]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[217]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[498]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[282]
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Drug(s) Affected By TRAF-interacting protein with FHA domain-containing protein B (TIFAB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
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Drug(s) Affected By Serine/threonine-protein kinase Nek10 (NEK10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[198]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[284]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[219]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[774]
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Drug(s) Affected By Olfactory receptor 2W3 (OR2W3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fenfluramine	DM0762O	Dravet syndrome	8A61.11	Phase 3	[775]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[217]
1,6-hexamethylene diisocyanate	DMLB3RT	Discovery agent	N.A.	Investigative	[776]
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Drug(s) Affected By Cilia- and flagella-associated protein 91 (CFAP91)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[214]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[214]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[214]
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Drug(s) Affected By Complement C1q-like protein 2 (C1QL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[207]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
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Drug(s) Affected By Uncharacterized protein C11orf96 (C11ORF96)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[615]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[219]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[214]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[220]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[210]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[206]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[234]
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Drug(s) Affected By Retrotransposon-derived protein PEG10 (PEG10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[264]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[301]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[777]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[86]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[75]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[579]
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Drug(s) Affected By E3 ubiquitin-protein ligase MARCHF3 (MARCHF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[196]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[279]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[244]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[205]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[76]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[124]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[212]
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Drug(s) Affected By Calcium-binding protein 7 (CABP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[207]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[218]
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Drug(s) Affected By Protein FAM124A (FAM124A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[214]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[198]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[200]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[208]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[219]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[218]
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Drug(s) Affected By Regulator of DNA class I crossover intermediates 1 (REDIC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[4]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[715]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
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Drug(s) Affected By Testis development-related protein (TDRP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[214]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[684]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[721]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[721]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[214]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[262]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[219]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[718]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[218]
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Drug(s) Affected By Aprataxin and PNK-like factor (APLF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[240]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[229]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[234]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[207]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[240]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[200]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[217]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[218]
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Drug(s) Affected By Contactin-4 (CNTN4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[216]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[778]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[778]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[219]
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Drug(s) Affected By Sphingosine-1-phosphate phosphatase 2 (SGPP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[219]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[214]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[205]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[684]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[200]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[208]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[202]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[217]
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⏷ Show the Full List of 10 Drug(s)

Drug(s) Affected By E3 ubiquitin-protein ligase TRIM48 (TRIM48)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[216]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[272]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[73]
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Drug(s) Affected By Aquaporin-12A (AQP12A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
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Drug(s) Affected By Copine-9 (CPNE9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[779]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
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Drug(s) Affected By Ly6/PLAUR domain-containing protein 1 (LYPD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[220]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[205]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[230]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[780]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[206]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[234]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[124]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[200]
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Drug(s) Affected By Metallothionein-1M (MT1M)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[396]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[352]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[483]
Phenoxybenzamine	DM8KSQH	Malignant essential hypertension	BA00	Approved	[352]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[352]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[274]
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Drug(s) Affected By Ligand-dependent nuclear receptor corepressor-like protein (LCORL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[684]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[198]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[234]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[200]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[202]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[4]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[202]
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Drug(s) Affected By Polypeptide N-acetylgalactosaminyltransferase 16 (GALNT16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[86]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[356]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[205]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[230]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[356]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[356]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[200]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[4]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[781]
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Drug(s) Affected By Translocating chain-associated membrane protein 1-like 1 (TRAM1L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[198]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[216]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[202]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[4]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[213]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[217]
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Drug(s) Affected By UPF0728 protein C10orf53 (C10ORF53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[86]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[207]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[4]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
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Drug(s) Affected By Claudin-22 (CLDN22)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[234]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[217]
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Drug(s) Affected By Golgi-associated RAB2 interactor protein 2 (GARIN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[570]
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Drug(s) Affected By Sodium-dependent lysophosphatidylcholine symporter 1 (MFSD2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[219]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[263]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[294]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[244]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[782]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[264]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[264]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[258]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[198]
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Drug(s) Affected By Potassium voltage-gated channel subfamily H member 5 (KCNH5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[214]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[475]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[216]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[783]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[218]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[750]
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Drug(s) Affected By Beta-defensin 108B (DEFB108B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
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Drug(s) Affected By Olfactory receptor 9G4 (OR9G4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
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Drug(s) Affected By Putative aspartate aminotransferase, cytoplasmic 2 (GOT1L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[784]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[219]
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Drug(s) Affected By Rhox homeobox family member 1 (RHOXF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[785]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[207]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[225]
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Drug(s) Affected By C-C motif chemokine 4-like (CCL4L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[200]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[521]
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Drug(s) Affected By Disintegrin and metalloproteinase domain-containing protein 32 (ADAM32)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[234]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[200]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[262]
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Drug(s) Affected By Enkurin (ENKUR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[124]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[559]
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Drug(s) Affected By Epidermal growth factor receptor kinase substrate 8-like protein 1 (EPS8L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[219]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[279]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[786]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[198]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[208]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[217]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[682]
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Drug(s) Affected By Limb region 1 protein homolog (LMBR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[223]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[198]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[56]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[211]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[200]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[73]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[718]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[228]
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Drug(s) Affected By Sialidase-4 (NEU4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[223]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[198]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[208]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[213]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[227]
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Drug(s) Affected By Pancreatic progenitor cell differentiation and proliferation factor-like protein (PPDPFL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
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Drug(s) Affected By S-adenosylmethionine-dependent nucleotide dehydratase RSAD2 (RSAD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[406]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[787]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[406]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[244]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[220]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[445]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[788]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[230]
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Drug(s) Affected By Barttin (BSND)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[216]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
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Drug(s) Affected By Transmembrane protein 158 (TMEM158)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[270]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[372]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[244]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[230]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[662]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[124]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[225]
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Drug(s) Affected By Roundabout homolog 4 (ROBO4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[198]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[207]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[199]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[208]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[737]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[789]
AHPN	DM8G6O4	Discovery agent	N.A.	Investigative	[790]
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Drug(s) Affected By CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase (ST8SIA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[233]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[684]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[281]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[202]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[4]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[208]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
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Drug(s) Affected By Rap guanine nucleotide exchange factor 5 (RAPGEF5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[233]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[791]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[198]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[216]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[225]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[520]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[202]
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Drug(s) Affected By Nuclear receptor subfamily 4 group A member 3 (NR4A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[43]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[406]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[406]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[434]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[274]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[406]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[258]
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Drug(s) Affected By Tetratricopeptide repeat protein 9A (TTC9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[442]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[223]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[445]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[197]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[205]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[198]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[234]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[200]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
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Drug(s) Affected By Hyaluronan synthase 1 (HAS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[208]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[792]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[792]
GUAIACOL	DMN4E7T	N. A.	N. A.	Phase 3	[792]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[792]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[793]
Puerarin	DMJIMXH	Alcohol dependence	6C40.2	Phase 2	[792]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
Chlorogenic acid	DM2Y3P4	Discovery agent	N.A.	Investigative	[792]
methyl p-hydroxybenzoate	DMO58UW	Discovery agent	N.A.	Investigative	[794]
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Drug(s) Affected By Ninjurin-1 (NINJ1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[305]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[562]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[434]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[86]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[562]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[356]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[356]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[228]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[356]
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Drug(s) Affected By Protein RFT1 homolog (RFT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[220]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[75]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[685]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[198]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[213]
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Drug(s) Affected By Solute carrier organic anion transporter family member 4A1 (SLCO4A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[795]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[223]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[75]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[205]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[198]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[796]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[201]
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Drug(s) Affected By E3 ubiquitin-protein ligase RNF183 (RNF183)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[86]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[220]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[198]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[216]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[225]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[208]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[797]
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Drug(s) Affected By Ras-related protein Rab-3C (RAB3C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[214]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[207]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[216]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[73]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[214]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[575]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[214]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
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Drug(s) Affected By Coiled-coil domain-containing protein 126 (CCDC126)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[530]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[218]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[200]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[213]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[798]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[719]
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Drug(s) Affected By E3 ubiquitin-protein ligase NEURL3 (NEURL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[339]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[220]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[228]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[230]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[559]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[228]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[278]
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Drug(s) Affected By ATP-dependent DNA helicase DDX11 (DDX11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Bortezomib	DMNO38U	Leukemia		Approved	[419]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[450]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[207]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[799]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[559]
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Drug(s) Affected By Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 (LINGO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[442]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[684]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[234]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[225]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[200]
Testosterone undecanoate	DMZO10Y	Hypogonadism	5A61.0	Approved	[800]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[226]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[221]
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Drug(s) Affected By Tumor protein D55 (TPD52L3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[225]
Fenfluramine	DM0762O	Dravet syndrome	8A61.11	Phase 3	[775]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
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Drug(s) Affected By 1,5-anhydro-D-fructose reductase (AKR1E2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[207]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[213]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[282]
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Drug(s) Affected By Beta-galactoside alpha-2,6-sialyltransferase 2 (ST6GAL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[295]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[200]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[4]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[214]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[637]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[219]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[218]
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Drug(s) Affected By E3 ubiquitin-protein ligase RNF170 (RNF170)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[223]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[218]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[230]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[198]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[207]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[199]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[226]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[213]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
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Drug(s) Affected By TNFAIP3-interacting protein 3 (TNIP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[205]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[230]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[124]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[203]
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Drug(s) Affected By Spermatogenesis-associated protein 17 (SPATA17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[215]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[258]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[206]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[234]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[755]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[202]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[4]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[282]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[750]
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Drug(s) Affected By Protein FAM227B (FAM227B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[211]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[225]
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Drug(s) Affected By Leucine-rich repeat and guanylate kinase domain-containing protein (LRGUK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[234]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[284]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[219]
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Drug(s) Affected By Guanylate-binding protein 5 (GBP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[205]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[230]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[198]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[801]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[200]
Nabiximols	DMHKJ5I	Cancer related pain	MG30	Phase 3	[802]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[783]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
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Drug(s) Affected By Cyclin-dependent kinase 15 (CDK15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[684]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[216]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[637]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[219]
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Drug(s) Affected By Protocadherin-15 (PCDH15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[207]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[4]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[208]
Chlorothiazide	DMLHESP	Chronic heart failure	BD1Z	Approved	[803]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[498]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[219]
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Drug(s) Affected By Retinoid-binding protein 7 (RBP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[442]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[198]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[804]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[249]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[202]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[208]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[214]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[217]
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Drug(s) Affected By Proheparin-binding EGF-like growth factor (HBEGF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[465]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[805]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[806]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[71]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[807]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[279]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[294]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
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Drug(s) Affected By Glutamate decarboxylase 1 (GAD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[103]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[676]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[214]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[220]
Isoflurophate	DMBSK7X	Glaucoma/ocular hypertension	9C61	Approved	[537]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[643]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[695]
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Drug(s) Affected By Perilipin-2 (PLIN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[808]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[264]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[286]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[196]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[356]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[809]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[127]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[75]
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Drug(s) Affected By C-C motif chemokine 19 (CCL19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[152]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[160]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[550]
Capecitabine	DMTS85L	Adenocarcinoma	2D40	Approved	[810]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[216]
EUGENOL	DM7US1H	Discovery agent	N.A.	Patented	[539]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[228]
PHENCYCLIDINE	DMQBEYX	Discovery agent	N.A.	Investigative	[811]
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Drug(s) Affected By Osteoclast stimulatory transmembrane protein (OCSTAMP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
ANW-32821	DMMJOZD	N. A.	N. A.	Phase 2	[552]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
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Drug(s) Affected By Leucine zipper putative tumor suppressor 2 (LZTS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[223]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[230]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[198]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[213]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[798]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[498]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[498]
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Drug(s) Affected By Oxidoreductase HTATIP2 (HTATIP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[77]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[372]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[86]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[356]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[356]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[311]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[445]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[311]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
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Drug(s) Affected By Receptor for retinol uptake STRA6 (STRA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[214]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[354]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[230]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[225]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[214]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[4]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[812]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[214]
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Drug(s) Affected By Plasmalemma vesicle-associated protein (PLVAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[305]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[199]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[219]
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Drug(s) Affected By Tudor domain-containing protein 1 (TDRD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[270]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[230]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
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Drug(s) Affected By Electrogenic sodium bicarbonate cotransporter 4 (SLC4A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[779]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[275]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[219]
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Drug(s) Affected By Angiopoietin-related protein 4 (ANGPTL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[43]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[59]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[535]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[356]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[356]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[356]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[220]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[127]
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Drug(s) Affected By Iroquois-class homeodomain protein IRX-2 (IRX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[214]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[237]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[216]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[813]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[202]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[4]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[226]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[202]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[214]
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Drug(s) Affected By Normal mucosa of esophagus-specific gene 1 protein (C15ORF48)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[339]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[483]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[279]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[220]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[814]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[205]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[216]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[815]
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Drug(s) Affected By Serine-rich coiled-coil domain-containing protein 1 (CCSER1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[207]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[816]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[219]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[218]
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Drug(s) Affected By Guanylate-binding protein 3 (GBP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[339]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[220]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[207]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[199]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[200]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[202]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[637]
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⏷ Show the Full List of 10 Drug(s)

Drug(s) Affected By Aryl hydrocarbon receptor nuclear translocator 2 (ARNT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[556]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[59]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[214]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[196]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[220]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[205]
Isoproterenol	DMK7MEY	Atrioventricular block		Approved	[679]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[786]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[234]
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Drug(s) Affected By Transcription factor HES-4 (HES4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[219]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[205]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[230]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[206]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[234]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[199]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[73]
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Drug(s) Affected By Transcription factor 7-like 1 (TCF7L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[308]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[244]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[220]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[197]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[234]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[211]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[225]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[226]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[213]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[214]
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Drug(s) Affected By Fibroblast growth factor 22 (FGF22)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[817]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
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Drug(s) Affected By Palmdelphin (PALMD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[279]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[230]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[786]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[198]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[234]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[199]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[225]
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Drug(s) Affected By Interleukin-23 subunit alpha (IL23A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[406]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[241]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[406]
Misoprostol	DMHVJFK	Medical abortion	JA00.1Z	Approved	[818]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[419]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[406]
Bortezomib	DMNO38U	Leukemia		Approved	[819]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[198]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[406]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[406]
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Drug(s) Affected By Toll-like receptor 8 (TLR8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[820]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[821]
Nabiximols	DMHKJ5I	Cancer related pain	MG30	Phase 3	[802]
PF-4878691	DM24I0N	Melanoma	2C30	Phase 2	[822]
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Drug(s) Affected By Disrupted in schizophrenia 1 protein (DISC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[218]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[198]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[200]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[214]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[4]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[823]
Dextroamphetamine	DMMIHVP	Attention deficit hyperactivity disorder	6A05.Z	Approved	[824]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
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Drug(s) Affected By Serine/threonine-protein kinase 36 (STK36)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[270]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[198]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[200]
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Drug(s) Affected By Gamma-1-syntrophin (SNTG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[86]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[207]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
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Drug(s) Affected By Cerebral cavernous malformations 2 protein-like (CCM2L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[755]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[214]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[226]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[214]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[274]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[214]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[278]
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Drug(s) Affected By Acid-sensing ion channel 5 (ASIC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[124]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
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Drug(s) Affected By Interleukin-36 gamma (IL36G)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[279]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[228]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[205]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[685]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[825]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[718]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[228]
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Drug(s) Affected By Programmed cell death 1 ligand 1 (CD274)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[510]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[826]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[160]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[827]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[244]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[828]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
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Drug(s) Affected By Dentin sialophosphoprotein (DSPP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[829]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[830]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[831]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[832]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[229]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[784]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[675]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[833]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[284]
phenamil	DMJLUFM	Discovery agent	N.A.	Investigative	[831]
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Drug(s) Affected By Short transient receptor potential channel 4 (TRPC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[305]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[214]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[475]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[668]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[200]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[202]
Carbachol	DMX9K8F	Glaucoma/ocular hypertension	9C61	Approved	[834]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[217]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[218]
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Drug(s) Affected By Dickkopf-related protein 2 (DKK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[445]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[218]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[209]
Indomethacin	DMSC4A7	Bursitis		Approved	[232]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[124]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[675]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[637]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[219]
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Drug(s) Affected By Mucin-12 (MUC12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[219]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
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Drug(s) Affected By A disintegrin and metalloproteinase with thrombospondin motifs 6 (ADAMTS6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[223]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[274]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[198]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[234]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[202]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[213]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[637]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[799]
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Drug(s) Affected By Angiopoietin-related protein 2 (ANGPTL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[448]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[76]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[230]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[199]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[200]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[212]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[208]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[213]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[637]
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Drug(s) Affected By Protein BCAP (ODF2L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[86]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[779]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[200]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[217]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[835]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[219]
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Drug(s) Affected By B9 domain-containing protein 1 (B9D1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[223]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[198]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[200]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[202]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[213]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[73]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[219]
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Drug(s) Affected By E3 ubiquitin-protein ligase TRIM35 (TRIM35)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[234]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[199]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[225]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[213]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[799]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[73]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[217]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[228]
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Drug(s) Affected By Leucine zipper putative tumor suppressor 1 (LZTS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[214]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[244]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[75]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[205]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[230]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[206]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[206]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[202]
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Drug(s) Affected By Rabphilin-3A (RPH3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[836]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[282]
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Drug(s) Affected By Dystrobrevin alpha (DTNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[86]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[223]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[614]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[230]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[198]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[237]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[837]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[200]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[214]
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Drug(s) Affected By Protocadherin beta-12 (PCDHB12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[226]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[284]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[217]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[498]
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Drug(s) Affected By Protocadherin gamma-B1 (PCDHGB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
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Drug(s) Affected By Hypoxia-inducible lipid droplet-associated protein (HILPDA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[77]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[406]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[406]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[286]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[348]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[838]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[223]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
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Drug(s) Affected By EH domain-binding protein 1 (EHBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[305]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[244]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[75]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[237]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[199]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Acetylcholinesterase (AChE)	TT1RS9F	ACES_HUMAN	Inhibitor	[2]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 1A2 (CYP1A2)	DEJGDUW	CP1A2_HUMAN	Substrate	[3]
Cytochrome P450 2B6 (CYP2B6)	DEPKLMQ	CP2B6_HUMAN	Substrate	[3]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
1,5-anhydro-D-fructose reductase (AKR1E2)	OT7GBQEB	AKCL2_HUMAN	Gene/Protein Processing	[4]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 (PLCB4)	OTPA0QHW	PLCB4_HUMAN	Gene/Protein Processing	[4]
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial (CYP27B1)	OTTK98BH	CP27B_HUMAN	Gene/Protein Processing	[4]
A disintegrin and metalloproteinase with thrombospondin motifs 12 (ADAMTS12)	OTG7HEA2	ATS12_HUMAN	Gene/Protein Processing	[4]
A disintegrin and metalloproteinase with thrombospondin motifs 20 (ADAMTS20)	OTU0EKLN	ATS20_HUMAN	Gene/Protein Processing	[4]
A disintegrin and metalloproteinase with thrombospondin motifs 6 (ADAMTS6)	OTSZE6L4	ATS6_HUMAN	Gene/Protein Processing	[4]
Acetylcholinesterase (ACHE)	OT2H8HG6	ACES_HUMAN	Gene/Protein Processing	[5]
Acid-sensing ion channel 5 (ASIC5)	OT1KWTC1	ASIC5_HUMAN	Gene/Protein Processing	[4]
Acyl-CoA-binding domain-containing protein 5 (ACBD5)	OT7L16DY	ACBD5_HUMAN	Gene/Protein Processing	[4]
Acyl-coenzyme A thioesterase 6 (ACOT6)	OTDE5QKC	ACOT6_HUMAN	Gene/Protein Processing	[4]

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References

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