Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMXZ84M)

• Drug Name: Malathion Drug Info
• Synonyms: Calmathion; Camathion; Carbafos; Carbetovur; Carbetox; Carbofos; Carbophos; Celthion; Chemathion; Cimexan; Cleensheen; Cythion; Dorthion; Emmatos; Ethiolacar; Etiol; Extermathion; Flair; Forthion; Fosfothion; Fosfotion; Fyfanon; Hilthion; Karbofos; Kypfos; Malacide; Malafor; Malagran; Malakill; Malamar; Malaphele; Malaphos; Malasol; Malaspray; Malataf; Malathiazol; Malathione; Malathiozoo; Malathon; Malathyl; Malation; Malatol; Malatox; Maldison; Malmed; Malphos; Maltox; Mercaptothion; Mercaptotion; Moscarda; Oleophosphothion; Organoderm; Ovide; Paladin; Phosphothion; Prioderm; Sadofos; Sadophos; Sumitox; TAK; Taskil; Vetiol; Zithiol; Carbethoxy malathion; Detm ol ma; Detmol MA; Emmatos extra; Lice Rid;Malathion LV Concentrate; Malathion [USP]; Malation [Polish]; Maltox MLT; Mercaptosuccinic acid diethyl ester; Mercaptotion [Spanish]; Ortho Malathion; Siptox I; Vegfru malatox; AC 26691; EL 4049; Experimental insecticide 4049; Fog 3; Fosfotion 550; Hilthion 25wdp; IFO 13140; Latka 4049; Latka 4049 [Czech]; MET86C_SUPELCO; Malamar 50; Malathion 60; Malathion E50; OMS 1; PS86_SUPELCO; SF 60; Sadofos 30; American cyanamid 4,049; Derbac-M; ENT 17,034; Four thousand forty-nine; Insecticide no. 4049; Kop-Thionkypfosmalacide; Kop-thion; Malathion (USP); Malathion (old ID); Ovide (TN); Staeubol-Puder; Suleo-M; TM-4049; Kill-A-Mite; MALATHION, 96%; Malathion-2,3-14C; 8059HC

Indication

Disease Entry	ICD 11	Status	REF
Pediculus capitis infestation	1G00.0	Approved	[1]

• Therapeutic Class: Parasympathomimetics
• Cross-matching ID:
  PubChem CID: 4004
  ChEBI ID: CHEMBL6651
  CAS Number: CAS 121-75-5
  TTD Drug ID: DMXZ84M
  INTEDE Drug ID: DR1000
  ACDINA Drug ID: D01234

Molecule-Related Drug Atlas

Drug(s) Targeting Acetylcholinesterase (AChE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[5]
Donepezil	DMIYG7Z	Advanced cancer	2A00-2F9Z	Approved	[6]
Galantamine	DMEO794	Alzheimer disease	8A20	Approved	[7]
Huperzine A	DMMAWLU	Alzheimer disease	8A20	Approved	[8]
Neostigmine	DM6T2J3	Myasthenia gravis	8C6Y	Approved	[9]
YM443	DMNZCI1	Functional dyspepsia	DD90.3	Approved	[10]
Ambenonium	DMOP0BL	Myasthenia gravis	8C6Y	Approved	[11]
Demecarium bromide	DMAYEU1	Open-angle glaucoma	9C61	Approved	[12]
Isoflurophate	DMBSK7X	Glaucoma/ocular hypertension	9C61	Approved	[13]
Pyridostigmine	DM8HO1L	Myasthenia gravis	8C6Y	Approved	[14]

Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[15]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[16]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[17]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[18]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[19]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[20]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[21]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[22]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[23]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[24]

Drug(s) Metabolized By Cytochrome P450 2B6 (CYP2B6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[25]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[26]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[27]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[28]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[30]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[31]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[32]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[33]
Amitriptyline	DMK7F9S	Depression	6A70-6A7Z	Approved	[34]

Drug(s) Affected By Mitotic checkpoint serine/threonine-protein kinase BUB1 (BUB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[35]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[36]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[38]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[42]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[42]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[43]

Drug(s) Affected By Replication factor C subunit 3 (RFC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[35]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[44]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[42]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[47]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[48]

Drug(s) Affected By Centromere protein F (CENPF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[38]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[42]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[42]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[43]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]

Drug(s) Affected By Aldo-keto reductase family 1 member C2 (AKR1C2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[52]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[53]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[54]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[55]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[56]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[52]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[57]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]

Drug(s) Affected By Aldo-keto reductase family 1 member C1 (AKR1C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[59]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[52]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[53]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[60]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[52]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[52]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[61]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[62]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[60]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[52]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 3 (NR1I3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[63]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[64]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[65]
Artemether	DM48QOT	Malaria	1F40-1F45	Approved	[66]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[67]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[68]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[69]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[70]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[71]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]

Drug(s) Affected By Shootin-1 (SHTN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[72]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[73]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[47]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[75]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[76]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[4]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[77]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[78]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[79]

Drug(s) Affected By Protein shisa-3 homolog (SHISA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[81]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[82]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[83]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[83]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[84]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[4]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[85]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]

Drug(s) Affected By Odontogenic ameloblast-associated protein (ODAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[42]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[87]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[88]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[76]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[89]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[90]

Drug(s) Affected By ADP-ribose glycohydrolase MACROD2 (MACROD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[92]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[93]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[85]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[91]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[94]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[95]

Drug(s) Affected By Myosin-binding protein H-like (MYBPHL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[85]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[90]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[94]

Drug(s) Affected By Geminin coiled-coil domain-containing protein 1 (GMNC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]

Drug(s) Affected By Pleckstrin homology domain-containing family D member 1 (PLEKHD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[96]

Drug(s) Affected By Calpain-8 (CAPN8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[93]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[4]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[98]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]

Drug(s) Affected By Elongin BC and Polycomb repressive complex 2-associated protein (EPOP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[100]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[101]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[102]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[103]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[104]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[105]

Drug(s) Affected By EF-hand calcium-binding domain-containing protein 9 (EFCAB9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[84]

Drug(s) Affected By Olfactory receptor 11H12 (OR11H12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[106]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]

Drug(s) Affected By Transmembrane protein 114 (TMEM114)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[107]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]

Drug(s) Affected By Protein shisa-9 (SHISA9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[108]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[84]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[109]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]

Drug(s) Affected By Putative SEC14-like protein 6 (SEC14L6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[43]

Drug(s) Affected By Uncharacterized membrane protein C3orf80 (C3ORF80)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[110]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[111]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[102]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[85]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[112]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]

Drug(s) Affected By Homeobox protein Meis1 (MEIS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[113]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[113]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[107]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[113]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[84]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[93]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[102]

Drug(s) Affected By Nuclear factor 1 B-type (NFIB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[91]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[115]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[116]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[75]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[117]

Drug(s) Affected By Segment polarity protein dishevelled homolog DVL-1 (DVL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[118]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[119]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[111]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[120]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[76]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[121]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[122]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[118]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[123]

Drug(s) Affected By RIMS-binding protein 2 (RIMBP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[110]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[84]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[124]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[125]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[95]

Drug(s) Affected By 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial (CYP27B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcidiol	DMN4CV5	Hypophosphatemia		Approved	[126]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[127]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[107]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[128]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[129]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[130]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[131]

Drug(s) Affected By Interleukin-1 receptor-associated kinase-like 2 (IRAK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[132]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[133]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[105]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[134]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[135]

Drug(s) Affected By Unconventional myosin-Ib (MYO1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[136]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[137]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[47]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[138]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[129]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]

Drug(s) Affected By Growth arrest-specific protein 2 (GAS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[139]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[75]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[45]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[103]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[90]

Drug(s) Affected By Perilipin-1 (PLIN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[134]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[134]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[140]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[141]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[142]
OLEIC ACID	DM54O1Z	Discovery agent	N.A.	Investigative	[143]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[144]

Drug(s) Affected By Tudor domain-containing protein 6 (TDRD6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[4]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[45]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[96]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[95]

Drug(s) Affected By Serine protease inhibitor Kazal-type 4 (SPINK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[145]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[146]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[147]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[148]
Octanal	DMTN0OK	N. A.	N. A.	Investigative	[149]

Drug(s) Affected By Heat shock factor 2-binding protein (HSF2BP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[111]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[90]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[150]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[94]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[151]

Drug(s) Affected By Low-density lipoprotein receptor-related protein 3 (LRP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[82]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[107]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[111]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[76]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]

Drug(s) Affected By Disintegrin and metalloproteinase domain-containing protein 11 (ADAM11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[98]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[94]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[144]

Drug(s) Affected By Rab11 family-interacting protein 3 (RAB11FIP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[105]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[107]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[111]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[84]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[75]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[78]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]

Drug(s) Affected By NADH dehydrogenase iron-sulfur protein 7, mitochondrial (NDUFS7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[152]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[47]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[119]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[153]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[96]

Drug(s) Affected By Olfactory receptor 4F21 (OR4F21)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[154]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[94]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 15 (TNFSF15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[155]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[156]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[42]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[157]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[158]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[82]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[159]

Drug(s) Affected By Cholesterol 25-hydroxylase (CH25H)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[96]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[145]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[140]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[161]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[162]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[96]

Drug(s) Affected By Keratin, type I cytoskeletal 14 (KRT14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[163]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[164]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[164]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[165]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[166]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[47]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[167]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[164]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[168]
Methamphetamine	DMPM4SK	Anxiety		Approved	[169]

Drug(s) Affected By Fibrinogen gamma chain (FGG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[54]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[170]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[171]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[172]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[173]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[174]

Drug(s) Affected By Interstitial collagenase (MMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[35]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[175]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[176]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[177]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[155]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[178]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[179]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[180]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[181]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[182]

Drug(s) Affected By Metallothionein-1E (MT1E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[183]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[184]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[186]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[187]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[107]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[188]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[189]

Drug(s) Affected By Guanine nucleotide-binding protein G(i) subunit alpha-2 (GNAI2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[190]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[100]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[47]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[192]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[111]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[88]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[76]

Drug(s) Affected By Plasminogen activator inhibitor 2 (SERPINB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[193]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[194]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[164]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[164]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[195]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[196]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[133]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]

Drug(s) Affected By Neuroendocrine protein 7B2 (SCG5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[145]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[82]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[107]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[198]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[111]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[199]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[103]

Drug(s) Affected By Metallothionein-1B (MT1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[200]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[201]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[202]
Promegestone	DMK4S8I	Gynecological disease	GA6Z	Approved	[203]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[140]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[204]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[49]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[205]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[206]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[207]

Drug(s) Affected By Profilin-1 (PFN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[154]
Selenium	DM25CGV	N. A.	N. A.	Approved	[190]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[208]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[209]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[210]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[211]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[212]
Haloperidol	DM96SE0	Delirium		Approved	[213]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[214]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[47]

Drug(s) Affected By Pulmonary surfactant-associated protein B (SFTPB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[215]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[216]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[43]
Terbutaline	DMD4381	Asthma	CA23	Approved	[217]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[217]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[218]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[219]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[218]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[218]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[4]

Drug(s) Affected By Collagen alpha-2(I) chain (COL1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[91]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[220]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[221]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[222]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[223]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[47]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[140]

Drug(s) Affected By Stromelysin-1 (MMP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[224]
Fluvastatin	DM4MDJY	Arteriosclerosis	BD40	Approved	[224]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[224]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[224]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[225]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[226]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[177]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[227]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[228]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[180]

Drug(s) Affected By Hepatocyte growth factor receptor (MET)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cabozantinib	DMIYDT4	Medullary thyroid gland carcinoma		Approved	[229]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[230]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[231]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[231]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[231]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[232]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[231]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[233]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[232]

Drug(s) Affected By Alpha-2A adrenergic receptor (ADRA2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[88]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[224]
Rilmenidine	DM13PQW	Hypertension	BA00-BA04	Approved	[234]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[152]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[110]
Oxymetazoline	DM8ZXT6	Arrhythmia	BC9Z	Approved	[235]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Indapamide	DMGN1PW	Edema	MG29	Approved	[236]

Drug(s) Affected By Stromelysin-2 (MMP10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[45]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[193]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[232]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[61]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[164]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[232]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[164]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[160]
Haloperidol	DM96SE0	Delirium		Approved	[213]

Drug(s) Affected By Myocardial zonula adherens protein (MYZAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[190]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[237]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[152]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[238]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[110]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[239]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[75]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[76]

Drug(s) Affected By Coiled-coil domain-containing protein 192 (CCDC192)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[240]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[241]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[242]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[243]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[244]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[245]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[194]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[231]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[246]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[247]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[231]

Drug(s) Affected By C-C motif chemokine 3 (CCL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[248]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[215]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[249]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[250]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[210]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[251]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[252]
Betamethasone	DMAHJEF	Acute adrenal insufficiency		Approved	[253]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[253]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[248]

Drug(s) Affected By Platelet factor 4 variant (PF4V1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[150]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[95]

Drug(s) Affected By Retinol-binding protein 3 (RBP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[93]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[85]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]
MG-132	DMKA2YS	N. A.	N. A.	Preclinical	[254]

Drug(s) Affected By Fibroblast growth factor 6 (FGF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[255]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[159]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[256]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]
AMINOHIPPURIC ACID	DMUN54G	Discovery agent	N.A.	Investigative	[257]

Drug(s) Affected By Nucleoprotein TPR (TPR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[154]
Selenium	DM25CGV	N. A.	N. A.	Approved	[190]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[258]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[118]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[259]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[223]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[47]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[213]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[213]

Drug(s) Affected By HLA class I histocompatibility antigen, alpha chain E (HLA-E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[260]
Clindamycin	DM15HL8	Acne vulgaris	ED80	Approved	[260]
Selenium	DM25CGV	N. A.	N. A.	Approved	[190]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[260]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[260]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[118]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[152]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[251]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[260]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]

Drug(s) Affected By Plastin-3 (PLS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]
Haloperidol	DM96SE0	Delirium		Approved	[213]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[47]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[213]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[261]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[75]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[103]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[262]

Drug(s) Affected By Beta-1,4-galactosyltransferase 1 (B4GALT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[196]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[133]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[105]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[47]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[140]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[263]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[263]
Estriol	DMOEM2I	Hormone deficiency	5A61.1	Approved	[263]

Drug(s) Affected By Paired box protein Pax-1 (PAX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[42]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[84]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[88]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[144]

Drug(s) Affected By Desmoplakin (DSP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[165]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[160]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[220]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[43]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[214]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[264]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[76]

Drug(s) Affected By Ankyrin-1 (ANK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[42]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[42]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[223]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[265]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[111]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[84]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[266]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[103]

Drug(s) Affected By C-C motif chemokine 3-like 1 (CCL3L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[267]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[215]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[183]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[82]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[268]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[269]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[270]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[271]
EUGENOL	DM7US1H	Discovery agent	N.A.	Patented	[272]

Drug(s) Affected By Elafin (PI3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[134]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[145]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[82]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[273]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[93]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[206]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[76]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[77]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]

Drug(s) Affected By C-C motif chemokine 1 (CCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[274]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[105]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[157]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[275]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[276]
ACYLINE	DM9GRTK	Prostate cancer	2C82.0	Phase 2	[277]
ANW-32821	DMMJOZD	N. A.	N. A.	Phase 2	[278]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[279]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[280]
Nickel chloride	DMI12Y8	Discovery agent	N.A.	Investigative	[281]

Drug(s) Affected By Nuclear receptor subfamily 4immunitygroup A member 1 (NR4A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[282]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[54]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[170]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[72]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[283]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[42]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[42]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[43]
Febuxostat	DMDEXQ0	Hyperuricaemia	5C55.Y	Approved	[284]

Drug(s) Affected By Vitamin K-dependent protein Z (PROZ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[100]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[134]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[111]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[84]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[4]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[285]

Drug(s) Affected By Protein S100-A1 (S100A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[136]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[164]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[164]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[100]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[286]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[164]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[111]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[120]

Drug(s) Affected By Oligodendrocyte-myelin glycoprotein (OMG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[287]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[288]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[160]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[288]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[289]

Drug(s) Affected By Chymase (CMA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[150]
paraquat	DMR8O3X	Discovery agent	N.A.	Investigative	[290]

Drug(s) Affected By Endothelin receptor type B (EDNRB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[287]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[291]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[91]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[110]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[223]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[73]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[292]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[293]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[294]

Drug(s) Affected By SHC-transforming protein 1 (SHC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[295]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[200]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[296]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[47]
Bortezomib	DMNO38U	Leukemia		Approved	[297]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[298]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[75]

Drug(s) Affected By Protein PML (PML)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[190]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[299]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[300]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[301]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[300]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[47]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[158]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[302]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[302]

Drug(s) Affected By Guanylate-binding protein 1 (GBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[113]
Selenium	DM25CGV	N. A.	N. A.	Approved	[190]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[232]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[170]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[232]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[42]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[223]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]

Drug(s) Affected By Pro-adrenomedullin (ADM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[303]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[304]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[215]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[297]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[305]

Drug(s) Affected By Macrophage metalloelastase (MMP12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[232]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[61]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[232]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[251]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[42]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[232]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]

Drug(s) Affected By Platelet glycoprotein V (GP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[306]

Drug(s) Affected By Transcription factor ETV6 (ETV6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[47]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[307]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[308]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[115]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[75]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[78]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[307]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[309]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[310]

Drug(s) Affected By C-X-C motif chemokine 5 (CXCL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[35]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[226]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[91]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[200]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[157]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[293]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[82]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[311]

Drug(s) Affected By Transcription factor GATA-4 (GATA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[312]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[313]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[91]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[314]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[315]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[316]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[317]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[84]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[76]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[4]

Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[190]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[237]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[132]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[318]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[319]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[47]

Drug(s) Affected By Tissue factor pathway inhibitor 2 (TFPI2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[91]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[160]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[47]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[82]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[107]

Drug(s) Affected By DNA replication licensing factor MCM2 (MCM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[193]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[320]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[301]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[156]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[42]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[201]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[47]

Drug(s) Affected By Type I iodothyronine deiodinase (DIO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[321]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[238]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Ergocalciferol	DMHO0AR	Hypoparathyroidism	5A50	Approved	[322]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[323]
Masoprocol	DMMVNZ0	Prostate cancer	2C82.0	Approved	[322]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[87]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[324]

Drug(s) Affected By Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' (PDE6C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[102]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[325]
Methamphetamine	DMPM4SK	Anxiety		Approved	[326]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[105]

Drug(s) Affected By AF4/FMR2 family member 1 (AFF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[100]
Bortezomib	DMNO38U	Leukemia		Approved	[327]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[108]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[328]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[76]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[329]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]

Drug(s) Affected By CCAAT/enhancer-binding protein gamma (CEBPG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[118]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[160]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[330]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[108]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[331]

Drug(s) Affected By Cysteine-rich secretory protein 3 (CRISP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[300]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[239]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[138]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[141]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[332]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[138]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]

Drug(s) Affected By GTP-binding protein RAD (RRAD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[145]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[133]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[223]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[105]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[333]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[107]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[129]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]

Drug(s) Affected By Claudin-12 (CLDN12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[42]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[107]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[88]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[76]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[121]

Drug(s) Affected By A disintegrin and metalloproteinase with thrombospondin motifs 12 (ADAMTS12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[334]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[88]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[76]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[85]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[285]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[94]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[96]

Drug(s) Affected By A disintegrin and metalloproteinase with thrombospondin motifs 20 (ADAMTS20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[335]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[133]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[239]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[199]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[336]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[337]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[78]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[95]

Drug(s) Affected By Myelin proteolipid protein (PLP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[91]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[110]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[47]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[101]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[338]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[4]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[89]

Drug(s) Affected By Protein BTG1 (BTG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[339]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[288]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[340]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[211]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[341]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[288]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[100]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[105]

Drug(s) Affected By Guanine nucleotide-binding protein G(i) subunit alpha-1 (GNAI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[47]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[37]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[75]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[90]

Drug(s) Affected By Pituitary homeobox 1 (PITX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[190]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[342]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[107]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[111]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[161]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[343]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[89]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[85]

Drug(s) Affected By Reelin (RELN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[344]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[100]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[47]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[345]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[93]

Drug(s) Affected By C-C motif chemokine 20 (CCL20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[193]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[194]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[226]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[232]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[274]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[232]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[133]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[43]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[346]

Drug(s) Affected By C-C motif chemokine 7 (CCL7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[226]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[274]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[274]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Isoproterenol	DMK7MEY	Atrioventricular block		Approved	[347]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[76]
Abexinostat	DM91LGU	Follicular lymphoma	2A80	Phase 3	[348]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[150]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[349]
Nickel chloride	DMI12Y8	Discovery agent	N.A.	Investigative	[281]

Drug(s) Affected By Serine protease HTRA4 (HTRA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[350]
L-serine	DM6WPIS	Pulmonary tuberculosis	1B10.Z	Investigative	[351]

Drug(s) Affected By Tumor necrosis factor-inducible gene 6 protein (TNFAIP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[226]
Selenium	DM25CGV	N. A.	N. A.	Approved	[267]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[231]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[251]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[231]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[231]
Trihexyphenidyl	DMB19L8	Dystonia	8A02	Approved	[231]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[231]

Drug(s) Affected By Forkhead box protein O4 (FOXO4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[118]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[42]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[100]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[352]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[353]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[354]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[83]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[108]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[102]

Drug(s) Affected By Histone-lysine N-methyltransferase 2A (KMT2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[355]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[356]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[160]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[223]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[357]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[358]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[359]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[108]

Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[225]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[360]
Selenium	DM25CGV	N. A.	N. A.	Approved	[190]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[299]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[361]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[362]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[363]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[118]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[364]

Drug(s) Affected By Homeobox protein engrailed-1 (EN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[316]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[316]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[86]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[88]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[85]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[365]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]

Drug(s) Affected By Epithelial discoidin domain-containing receptor 1 (DDR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[220]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[82]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[352]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[366]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[317]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[76]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[317]

Drug(s) Affected By Calcium-activated potassium channel subunit alpha-1 (KCNMA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[96]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[237]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[72]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[107]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[92]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[115]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[84]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[367]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[161]

Drug(s) Affected By Protein disulfide-isomerase A2 (PDIA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[368]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[111]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[369]
Vitamin C	DMXJ7O8	Adenocarcinoma	2D40	Approved	[370]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[85]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[371]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[150]

Drug(s) Affected By G protein pathway suppressor 2 (GPS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[100]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[372]
Z-Pro-Prolinal	DM43O2U	Discovery agent	N.A.	Investigative	[373]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[374]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[375]

Drug(s) Affected By NAD(P) transhydrogenase, mitochondrial (NNT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[136]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[47]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[213]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[107]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[376]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[376]

Drug(s) Affected By Voltage-dependent L-type calcium channel subunit alpha-1C (CACNA1C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[96]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[237]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[377]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[378]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Retigabine	DMGNYIH	Behcet disease	4A62	Approved	[379]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[48]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[84]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[76]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[380]

Drug(s) Affected By Core-binding factor subunit beta (CBFB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[303]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[184]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[160]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[47]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[184]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]

Drug(s) Affected By Carcinoembryonic antigen-related cell adhesion molecule 7 (CEACAM7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[170]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[82]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[102]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]

Drug(s) Affected By Double C2-like domain-containing protein beta (DOC2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[85]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[310]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]

Drug(s) Affected By Interleukin-27 subunit beta (EBI3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[226]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Epanova	DMHEAGL	Hypertriglyceridemia	5C80.1	Approved	[381]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[82]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[382]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[111]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[383]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[76]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[91]

Drug(s) Affected By Fibroblast growth factor-binding protein 1 (FGFBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[133]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[384]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[82]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[84]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[207]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[385]
Seocalcitol	DMKL9QO	Rickets	5B57	Phase 3	[386]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[98]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]

Drug(s) Affected By Interleukin-13 receptor subunit alpha-2 (IL13RA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[387]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[293]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[82]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[107]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[353]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[334]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[276]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[388]

Drug(s) Affected By Serine/threonine-protein kinase D1 (PRKD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[42]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[111]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[84]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[102]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[76]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[90]

Drug(s) Affected By 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 (PLCB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[190]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[220]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[111]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[93]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[76]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[78]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[77]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[190]
Sphingosine-1-phosphate	DMJCQKA	Acne vulgaris	ED80	Phase 1	[389]

Drug(s) Affected By Receptor tyrosine-protein kinase erbB-4 (ERBB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[390]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[391]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[91]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[188]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[392]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[308]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[84]

Drug(s) Affected By Olfactory receptor 4D1 (OR4D1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[88]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[393]

Drug(s) Affected By Disks large homolog 2 (DLG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[213]
Haloperidol	DM96SE0	Delirium		Approved	[213]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[202]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[213]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[213]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[174]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[138]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[90]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]

Drug(s) Affected By Rhodopsin kinase GRK1 (GRK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]

Drug(s) Affected By Heat shock protein beta-2 (HSPB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[394]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[199]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[395]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[206]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[85]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[396]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[94]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[397]
linalool	DMGZQ5P	Discovery agent	N.A.	Investigative	[398]

Drug(s) Affected By Cocaine- and amphetamine-regulated transcript protein (CARTPT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[399]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[400]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[78]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]

Drug(s) Affected By Dual specificity protein phosphatase 5 (DUSP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[193]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[304]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[91]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[401]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[145]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[42]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[402]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[133]

Drug(s) Affected By Plasma membrane calcium-transporting ATPase 3 (ATP2B3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[96]

Drug(s) Affected By Serine protease inhibitor Kazal-type 13 (SPINK13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[84]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[161]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[150]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[374]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[403]

Drug(s) Affected By UDP-N-acetylglucosamine transporter TMEM241 (TMEM241)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[107]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[120]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[90]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[94]

Drug(s) Affected By MHC class I polypeptide-related sequence A (MICA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[404]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[405]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[100]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[406]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[407]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[107]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[83]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[83]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[84]

Drug(s) Affected By Prospero homeobox protein 2 (PROX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]

Drug(s) Affected By Acyl-coenzyme A thioesterase 6 (ACOT6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[84]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[408]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]
CITCO	DM0N634	Discovery agent	N.A.	Investigative	[409]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[96]

Drug(s) Affected By Ankyrin repeat domain-containing protein 55 (ANKRD55)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[84]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[90]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[78]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[410]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[96]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[144]

Drug(s) Affected By Keratin-associated protein 27-1 (KRTAP27-1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[4]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]

Drug(s) Affected By Keratin-associated protein 13-3 (KRTAP13-3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]

Drug(s) Affected By Uncharacterized protein C8orf34 (C8ORF34)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[91]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[133]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[239]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[411]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[91]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[91]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[96]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[95]

Drug(s) Affected By Protein FAM229B (FAM229B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[100]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[73]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[192]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[78]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[94]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[96]

Drug(s) Affected By Filamin A-interacting protein 1-like (FILIP1L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[412]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[220]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[100]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[39]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[82]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[261]

Drug(s) Affected By Quinone oxidoreductase PIG3 (TP53I3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[413]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[155]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[414]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[415]
Amifostine	DM5FL14	Mucositis	CA00	Approved	[416]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[417]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[402]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[402]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[402]

Drug(s) Affected By Interferon-induced protein 44-like (IFI44L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[232]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[232]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[145]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[384]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[223]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[91]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[105]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[107]

Drug(s) Affected By Tumor necrosis factor alpha-induced protein 8-like protein 3 (TNFAIP8L3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[133]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[107]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[76]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[90]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[79]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[289]

Drug(s) Affected By Cilia- and flagella-associated protein 157 (CFAP157)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[102]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]

Drug(s) Affected By Ephrin type-A receptor 10 (EPHA10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[418]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[84]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[102]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[4]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[85]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[418]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[144]

Drug(s) Affected By Sperm protein associated with the nucleus on the X chromosome N3 (SPANXN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[133]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[88]

Drug(s) Affected By Speedy protein A (SPDYA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[111]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[138]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]

Drug(s) Affected By Trichohyalin-like protein 1 (TCHHL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[96]

Drug(s) Affected By Late cornified envelope-like proline-rich protein 1 (LELP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[419]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[92]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[88]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]
PMID27336223-Compound-5	DM6E50A	N. A.	N. A.	Patented	[419]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[374]

Drug(s) Affected By Acyl-CoA-binding domain-containing protein 5 (ACBD5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[47]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[75]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[76]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[4]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[94]

Drug(s) Affected By Armadillo repeat-containing protein 3 (ARMC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[102]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[98]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]

Drug(s) Affected By Lysophospholipid acyltransferase LPCAT4 (LPCAT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[47]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[93]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[76]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[78]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[103]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[91]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[94]

Drug(s) Affected By Carboxypeptidase Z (CPZ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[160]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[220]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[293]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[88]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[89]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[85]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[393]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[94]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[96]

Drug(s) Affected By Kazrin (KAZN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[100]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[334]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[84]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[120]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[77]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[77]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[77]

Drug(s) Affected By LEM domain-containing protein 1 (LEMD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[145]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[353]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[325]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[103]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[91]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[420]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[98]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[374]

Drug(s) Affected By GRAM domain-containing protein 4 (GRAMD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[96]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[133]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[108]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[84]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[421]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[76]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[45]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[140]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[95]

Drug(s) Affected By Olfactory receptor 4F3/4F16/4F29 (OR4F16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[154]

Drug(s) Affected By Pre T-cell antigen receptor alpha (PTCRA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]

Drug(s) Affected By Transmembrane protein 65 (TMEM65)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[422]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[100]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[88]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[423]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[103]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[105]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[424]

Drug(s) Affected By Probable G-protein coupled receptor 179 (GPR179)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[393]

Drug(s) Affected By Opsin-5 (OPN5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[84]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[4]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[96]

Drug(s) Affected By ALK and LTK ligand 2 (ALKAL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[4]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[91]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[45]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[148]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[95]

Drug(s) Affected By R-spondin-2 (RSPO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[91]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[110]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[129]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[88]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[91]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[89]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[91]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[95]

Drug(s) Affected By Uncharacterized protein C12orf54 (C12ORF54)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[105]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[84]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[105]

Drug(s) Affected By Kinesin-like protein KIF6 (KIF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[425]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[84]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[88]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[78]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[426]
Rosuvastatin	DMMIQ7G	Arteriosclerosis	BD40	Approved	[426]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[426]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[78]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[427]

Drug(s) Affected By Protein lin-28 homolog B (LIN28B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[428]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[107]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[429]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[428]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[427]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[94]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[258]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[148]

Drug(s) Affected By TRAF-interacting protein with FHA domain-containing protein B (TIFAB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]

Drug(s) Affected By Serine/threonine-protein kinase Nek10 (NEK10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[150]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[96]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[430]

Drug(s) Affected By Olfactory receptor 2W3 (OR2W3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fenfluramine	DM0762O	Dravet syndrome	8A61.11	Phase 3	[431]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[94]
1,6-hexamethylene diisocyanate	DMLB3RT	Discovery agent	N.A.	Investigative	[432]

Drug(s) Affected By Cilia- and flagella-associated protein 91 (CFAP91)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[91]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[91]

Drug(s) Affected By Complement C1q-like protein 2 (C1QL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[84]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]

Drug(s) Affected By Uncharacterized protein C11orf96 (C11ORF96)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[303]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[96]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[87]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[83]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[111]

Drug(s) Affected By Retrotransposon-derived protein PEG10 (PEG10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[134]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[301]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[433]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[47]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[292]

Drug(s) Affected By E3 ubiquitin-protein ligase MARCHF3 (MARCHF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[72]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[145]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[133]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[82]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[48]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[199]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[89]

Drug(s) Affected By Calcium-binding protein 7 (CABP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[84]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[95]

Drug(s) Affected By Protein FAM124A (FAM124A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[76]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[85]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[96]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[95]

Drug(s) Affected By Regulator of DNA class I crossover intermediates 1 (REDIC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[4]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[371]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]

Drug(s) Affected By Testis development-related protein (TDRP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[352]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[434]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[434]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[91]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[427]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[96]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[374]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[95]

Drug(s) Affected By Aprataxin and PNK-like factor (APLF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[435]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[106]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[111]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[84]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[435]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[76]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[94]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[95]

Drug(s) Affected By Contactin-4 (CNTN4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[93]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[436]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[436]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[96]

Drug(s) Affected By Sphingosine-1-phosphate phosphatase 2 (SGPP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[96]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[82]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[352]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[76]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[85]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[78]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[94]

Drug(s) Affected By E3 ubiquitin-protein ligase TRIM48 (TRIM48)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[42]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[42]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[93]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[138]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[45]

Drug(s) Affected By Aquaporin-12A (AQP12A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]

Drug(s) Affected By Copine-9 (CPNE9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[437]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]

Drug(s) Affected By Ly6/PLAUR domain-containing protein 1 (LYPD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[82]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[107]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[438]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[83]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[111]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[199]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[76]

Drug(s) Affected By Metallothionein-1M (MT1M)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[183]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[439]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[251]
Phenoxybenzamine	DM8KSQH	Malignant essential hypertension	BA00	Approved	[439]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[439]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[140]

Drug(s) Affected By Ligand-dependent nuclear receptor corepressor-like protein (LCORL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[42]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[352]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[111]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[76]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[78]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[4]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[78]

Drug(s) Affected By Polypeptide N-acetylgalactosaminyltransferase 16 (GALNT16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[402]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[82]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[107]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[402]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[402]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[76]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[4]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[440]

Drug(s) Affected By Translocating chain-associated membrane protein 1-like 1 (TRAM1L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[93]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[78]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[4]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[90]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[94]

Drug(s) Affected By UPF0728 protein C10orf53 (C10ORF53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[84]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[4]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]

Drug(s) Affected By Claudin-22 (CLDN22)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[111]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[94]

Drug(s) Affected By Golgi-associated RAB2 interactor protein 2 (GARIN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[441]

Drug(s) Affected By Sodium-dependent lysophosphatidylcholine symporter 1 (MFSD2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[96]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[132]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[160]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[133]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[442]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[134]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[134]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[129]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]

Drug(s) Affected By Potassium voltage-gated channel subfamily H member 5 (KCNH5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[239]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[93]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[443]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[95]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[403]

Drug(s) Affected By Beta-defensin 108B (DEFB108B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]

Drug(s) Affected By Olfactory receptor 9G4 (OR9G4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]

Drug(s) Affected By Putative aspartate aminotransferase, cytoplasmic 2 (GOT1L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[444]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[96]

Drug(s) Affected By Rhox homeobox family member 1 (RHOXF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[445]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[84]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[102]

Drug(s) Affected By C-C motif chemokine 4-like (CCL4L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[76]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[271]

Drug(s) Affected By Disintegrin and metalloproteinase domain-containing protein 32 (ADAM32)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[111]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[76]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[427]

Drug(s) Affected By Enkurin (ENKUR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[38]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[199]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[285]

Drug(s) Affected By Epidermal growth factor receptor kinase substrate 8-like protein 1 (EPS8L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[96]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[145]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[42]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[42]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[446]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[85]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[94]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[350]

Drug(s) Affected By Limb region 1 protein homolog (LMBR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[100]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[37]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[88]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[76]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[45]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[374]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[105]

Drug(s) Affected By Sialidase-4 (NEU4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[100]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[85]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[90]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[104]

Drug(s) Affected By Pancreatic progenitor cell differentiation and proliferation factor-like protein (PPDPFL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]

Drug(s) Affected By S-adenosylmethionine-dependent nucleotide dehydratase RSAD2 (RSAD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[232]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[447]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[232]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[133]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[223]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[448]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[107]

Drug(s) Affected By Barttin (BSND)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[93]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]

Drug(s) Affected By Transmembrane protein 158 (TMEM158)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[136]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[182]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[133]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[107]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[331]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[199]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[102]

Drug(s) Affected By CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase (ST8SIA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[110]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[352]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[147]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[78]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[4]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[85]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]

Drug(s) Affected By Rap guanine nucleotide exchange factor 5 (RAPGEF5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[110]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[449]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[93]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[102]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[270]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[78]

Drug(s) Affected By Nuclear receptor subfamily 4 group A member 3 (NR4A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[224]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[232]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[232]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[211]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[140]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[232]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[129]

Drug(s) Affected By Tetratricopeptide repeat protein 9A (TTC9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[220]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[100]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[223]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[73]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[82]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[111]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[76]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]

Drug(s) Affected By Hyaluronan synthase 1 (HAS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[85]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[450]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[450]
GUAIACOL	DMN4E7T	N. A.	N. A.	Phase 3	[450]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[450]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[451]
Puerarin	DMJIMXH	Alcohol dependence	6C40.2	Phase 2	[450]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]
Chlorogenic acid	DM2Y3P4	Discovery agent	N.A.	Investigative	[450]
methyl p-hydroxybenzoate	DMO58UW	Discovery agent	N.A.	Investigative	[452]

Drug(s) Affected By Ninjurin-1 (NINJ1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[190]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[288]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[211]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[288]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[402]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[402]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[105]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[402]

Drug(s) Affected By Protein RFT1 homolog (RFT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[47]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[353]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[90]

Drug(s) Affected By Solute carrier organic anion transporter family member 4A1 (SLCO4A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[453]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[100]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[47]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[82]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[454]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[77]

Drug(s) Affected By E3 ubiquitin-protein ligase RNF183 (RNF183)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[93]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[102]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[85]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[455]

Drug(s) Affected By Ras-related protein Rab-3C (RAB3C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[84]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[93]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[45]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[91]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[325]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[91]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]

Drug(s) Affected By Coiled-coil domain-containing protein 126 (CCDC126)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[422]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[76]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[90]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[456]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[375]

Drug(s) Affected By E3 ubiquitin-protein ligase NEURL3 (NEURL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[170]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[105]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[107]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[285]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[105]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[144]

Drug(s) Affected By ATP-dependent DNA helicase DDX11 (DDX11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[42]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[42]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[43]
Bortezomib	DMNO38U	Leukemia		Approved	[327]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[334]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[84]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[457]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[285]

Drug(s) Affected By Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 (LINGO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[220]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[352]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[111]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[102]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[76]
Testosterone undecanoate	DMZO10Y	Hypogonadism	5A61.0	Approved	[458]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[103]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[98]

Drug(s) Affected By Tumor protein D55 (TPD52L3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[102]
Fenfluramine	DM0762O	Dravet syndrome	8A61.11	Phase 3	[431]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]

Drug(s) Affected By 1,5-anhydro-D-fructose reductase (AKR1E2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[84]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[90]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[148]

Drug(s) Affected By Beta-galactoside alpha-2,6-sialyltransferase 2 (ST6GAL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[161]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[76]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[4]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[91]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[310]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[96]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[95]

Drug(s) Affected By E3 ubiquitin-protein ligase RNF170 (RNF170)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[100]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[107]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[84]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[75]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[103]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[90]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]

Drug(s) Affected By TNFAIP3-interacting protein 3 (TNIP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[82]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[107]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[199]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[79]

Drug(s) Affected By Spermatogenesis-associated protein 17 (SPATA17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[92]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[129]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[83]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[111]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[408]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[78]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[4]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[148]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[403]

Drug(s) Affected By Protein FAM227B (FAM227B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[88]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[102]

Drug(s) Affected By Leucine-rich repeat and guanylate kinase domain-containing protein (LRGUK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[111]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[150]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[96]

Drug(s) Affected By Guanylate-binding protein 5 (GBP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[82]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[107]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[459]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[76]
Nabiximols	DMHKJ5I	Cancer related pain	MG30	Phase 3	[460]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[443]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]

Drug(s) Affected By Cyclin-dependent kinase 15 (CDK15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[352]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[93]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[310]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[96]

Drug(s) Affected By Protocadherin-15 (PCDH15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[84]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[4]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[85]
Chlorothiazide	DMLHESP	Chronic heart failure	BD1Z	Approved	[461]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[258]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[96]

Drug(s) Affected By Retinoid-binding protein 7 (RBP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[220]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[462]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[120]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[78]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[85]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[91]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[94]

Drug(s) Affected By Glutamate decarboxylase 1 (GAD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[237]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[344]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[91]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Isoflurophate	DMBSK7X	Glaucoma/ocular hypertension	9C61	Approved	[463]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[316]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[358]

Drug(s) Affected By Perilipin-2 (PLIN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[464]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[134]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[44]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[152]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[72]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[402]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[465]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[466]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[47]

Drug(s) Affected By C-C motif chemokine 19 (CCL19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[215]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[342]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[276]
Capecitabine	DMTS85L	Adenocarcinoma	2D40	Approved	[467]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[93]
EUGENOL	DM7US1H	Discovery agent	N.A.	Patented	[273]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[105]
PHENCYCLIDINE	DMQBEYX	Discovery agent	N.A.	Investigative	[468]

Drug(s) Affected By Osteoclast stimulatory transmembrane protein (OCSTAMP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[43]
ANW-32821	DMMJOZD	N. A.	N. A.	Phase 2	[278]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]

Drug(s) Affected By Leucine zipper putative tumor suppressor 2 (LZTS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[100]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[107]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[90]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[456]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[258]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[258]

Drug(s) Affected By Receptor for retinol uptake STRA6 (STRA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[91]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[200]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[107]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[102]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[91]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[4]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[469]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[91]

Drug(s) Affected By Plasmalemma vesicle-associated protein (PLVAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[190]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[75]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[96]

Drug(s) Affected By Tudor domain-containing protein 1 (TDRD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[136]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[107]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]

Drug(s) Affected By Iroquois-class homeodomain protein IRX-2 (IRX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[115]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[93]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[470]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[78]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[4]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[103]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[78]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[91]

Drug(s) Affected By Normal mucosa of esophagus-specific gene 1 protein (C15ORF48)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[170]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[251]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[145]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[471]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[82]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[93]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[472]

Drug(s) Affected By Serine-rich coiled-coil domain-containing protein 1 (CCSER1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[84]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[473]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[96]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[95]

Drug(s) Affected By Guanylate-binding protein 3 (GBP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[170]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[42]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[84]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[75]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[76]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[78]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[310]

Drug(s) Affected By Aryl hydrocarbon receptor nuclear translocator 2 (ARNT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[282]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[91]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[82]
Isoproterenol	DMK7MEY	Atrioventricular block		Approved	[347]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[446]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[111]

Drug(s) Affected By Transcription factor HES-4 (HES4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[96]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[82]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[107]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[83]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[111]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[75]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[45]

Drug(s) Affected By Transcription factor 7-like 1 (TCF7L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[318]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[133]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[73]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[111]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[88]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[102]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[103]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[90]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[91]

Drug(s) Affected By Fibroblast growth factor 22 (FGF22)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[474]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]

Drug(s) Affected By Interleukin-23 subunit alpha (IL23A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[232]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[475]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[232]
Misoprostol	DMHVJFK	Medical abortion	JA00.1Z	Approved	[476]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[327]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[232]
Bortezomib	DMNO38U	Leukemia		Approved	[477]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[232]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[232]

Drug(s) Affected By Disrupted in schizophrenia 1 protein (DISC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[76]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[91]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[4]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[478]
Dextroamphetamine	DMMIHVP	Attention deficit hyperactivity disorder	6A05.Z	Approved	[479]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]

Drug(s) Affected By Serine/threonine-protein kinase 36 (STK36)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[136]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[76]

Drug(s) Affected By Gamma-1-syntrophin (SNTG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[84]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]

Drug(s) Affected By Cerebral cavernous malformations 2 protein-like (CCM2L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[408]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[91]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[103]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[91]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[140]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[91]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[144]

Drug(s) Affected By Acid-sensing ion channel 5 (ASIC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[199]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]

Drug(s) Affected By Programmed cell death 1 ligand 1 (CD274)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[480]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[481]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[342]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[482]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[42]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[133]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[43]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[483]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]

Drug(s) Affected By Dentin sialophosphoprotein (DSPP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[484]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[485]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[486]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[487]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[106]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[444]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[343]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[488]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[150]
phenamil	DMJLUFM	Discovery agent	N.A.	Investigative	[486]

Drug(s) Affected By Mucin-12 (MUC12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]

Drug(s) Affected By A disintegrin and metalloproteinase with thrombospondin motifs 6 (ADAMTS6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[100]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[140]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[111]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[78]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[90]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[310]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[457]

Drug(s) Affected By Angiopoietin-related protein 2 (ANGPTL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[384]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[48]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[107]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[75]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[76]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[89]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[85]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[90]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[310]

Drug(s) Affected By Protein BCAP (ODF2L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[43]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[437]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[76]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[94]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[489]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[96]

Drug(s) Affected By B9 domain-containing protein 1 (B9D1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[100]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[76]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[78]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[90]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[45]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[96]

Drug(s) Affected By E3 ubiquitin-protein ligase TRIM35 (TRIM35)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[111]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[75]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[102]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[90]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[457]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[45]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[94]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[105]

Drug(s) Affected By Leucine zipper putative tumor suppressor 1 (LZTS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[91]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[133]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[47]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[82]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[107]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[83]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[83]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[78]

Drug(s) Affected By Dystrobrevin alpha (DTNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[100]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[490]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[107]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[115]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[491]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[76]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[91]

Drug(s) Affected By Protocadherin beta-12 (PCDHB12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[103]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[150]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[94]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[258]

Drug(s) Affected By Protocadherin gamma-B1 (PCDHGB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]

Drug(s) Affected By Hypoxia-inducible lipid droplet-associated protein (HILPDA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[232]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[232]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[152]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[184]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[492]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[100]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]

Drug(s) Affected By EH domain-binding protein 1 (EHBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[190]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[133]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[47]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[115]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[75]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Acetylcholinesterase (AChE)	TT1RS9F	ACES_HUMAN	Inhibitor	[2]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 1A2 (CYP1A2)	DEJGDUW	CP1A2_HUMAN	Substrate	[3]
Cytochrome P450 2B6 (CYP2B6)	DEPKLMQ	CP2B6_HUMAN	Substrate	[3]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
1,5-anhydro-D-fructose reductase (AKR1E2)	OT7GBQEB	AKCL2_HUMAN	Gene/Protein Processing	[4]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 (PLCB4)	OTPA0QHW	PLCB4_HUMAN	Gene/Protein Processing	[4]
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial (CYP27B1)	OTTK98BH	CP27B_HUMAN	Gene/Protein Processing	[4]
A disintegrin and metalloproteinase with thrombospondin motifs 12 (ADAMTS12)	OTG7HEA2	ATS12_HUMAN	Gene/Protein Processing	[4]
A disintegrin and metalloproteinase with thrombospondin motifs 20 (ADAMTS20)	OTU0EKLN	ATS20_HUMAN	Gene/Protein Processing	[4]
A disintegrin and metalloproteinase with thrombospondin motifs 6 (ADAMTS6)	OTSZE6L4	ATS6_HUMAN	Gene/Protein Processing	[4]
Acid-sensing ion channel 5 (ASIC5)	OT1KWTC1	ASIC5_HUMAN	Gene/Protein Processing	[4]
Acyl-CoA-binding domain-containing protein 5 (ACBD5)	OT7L16DY	ACBD5_HUMAN	Gene/Protein Processing	[4]
Acyl-coenzyme A thioesterase 6 (ACOT6)	OTDE5QKC	ACOT6_HUMAN	Gene/Protein Processing	[4]
ADP-ribose glycohydrolase MACROD2 (MACROD2)	OTNQCHC6	MACD2_HUMAN	Gene/Protein Processing	[4]

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