Details of the Drug Combination

General Information of Drug Combination (ID: DC9U5I8)

Drug Combination Name
Rigosertib Azacitidine
Indication
Disease Entry Status REF
Myelodysplastic Syndrome Phase 1 [1]
Component Drugs Rigosertib   DMOSTXF Azacitidine   DMTA5OE
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Rigosertib
Disease Entry ICD 11 Status REF
Myelodysplastic syndrome 2A37 Phase 3 [2]
Solid tumour/cancer 2A00-2F9Z Phase 3 [3]
Rigosertib Interacts with 2 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Polo-like kinase 1 (PLK1) TTIYVQP PLK1_HUMAN Modulator [8]
PI3-kinase gamma (PIK3CG) TTHBTOP PK3CG_HUMAN Modulator [8]
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Rigosertib Interacts with 143 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
NF-kappa-B inhibitor epsilon (NFKBIE) OTLAYEL9 IKBE_HUMAN Affects Expression [6]
Chloride intracellular channel protein 1 (CLIC1) OTYLFWNG CLIC1_HUMAN Increases Expression [6]
Nuclear factor 1 B-type (NFIB) OTX94PD0 NFIB_HUMAN Increases Expression [6]
Transcription regulator protein BACH1 (BACH1) OTY8004K BACH1_HUMAN Increases Expression [6]
Protein Mdm4 (MDM4) OTU10BSF MDM4_HUMAN Affects Expression [6]
3-phosphoinositide-dependent protein kinase 1 (PDPK1) OTT09ZVP PDPK1_HUMAN Decreases Phosphorylation [9]
Protein MTSS 1 (MTSS1) OT5DTDO2 MTSS1_HUMAN Increases Expression [6]
Bcl-2-like protein 11 (BCL2L11) OTNQQWFJ B2L11_HUMAN Increases Expression [10]
Cytohesin-interacting protein (CYTIP) OTRJ3ZC5 CYTIP_HUMAN Increases Expression [6]
F-box-like/WD repeat-containing protein TBL1X (TBL1X) OTXQ51E0 TBL1X_HUMAN Increases Expression [6]
Short-chain dehydrogenase/reductase 3 (DHRS3) OTSK1DTP DHRS3_HUMAN Affects Expression [6]
Serine/threonine-protein kinase Chk2 (CHEK2) OT8ZPCNS CHK2_HUMAN Increases Phosphorylation [11]
2'-5'-oligoadenylate synthase 1 (OAS1) OT8ZLOCY OAS1_HUMAN Decreases Expression [6]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Decreases Expression [9]
HLA class II histocompatibility antigen, DQ beta 1 chain (HLA-DQB1) OTVVI3UI DQB1_HUMAN Affects Expression [6]
Albumin (ALB) OTVMM513 ALBU_HUMAN Affects Binding [12]
Glucocorticoid receptor (NR3C1) OTCI2YDI GCR_HUMAN Increases Expression [6]
Receptor tyrosine-protein kinase erbB-2 (ERBB2) OTOAUNCK ERBB2_HUMAN Increases Phosphorylation [7]
Transcription factor Jun (JUN) OTCYBO6X JUN_HUMAN Increases Expression [6]
Tyrosine-protein kinase Lck (LCK) OT883FG9 LCK_HUMAN Increases Phosphorylation [7]
Tyrosine-protein kinase Fyn (FYN) OTLSLVZS FYN_HUMAN Increases Phosphorylation [7]
Cyclin-dependent kinase 1 (CDK1) OTW1SC2N CDK1_HUMAN Increases Expression [7]
Eukaryotic translation initiation factor 4E (EIF4E) OTDAWNLA IF4E_HUMAN Decreases Activity [9]
Macrophage colony-stimulating factor 1 receptor (CSF1R) OTDYTB9C CSF1R_HUMAN Increases Expression [6]
Proto-oncogene tyrosine-protein kinase receptor Ret (RET) OTLU040A RET_HUMAN Increases Phosphorylation [7]
Platelet-derived growth factor receptor beta (PDGFRB) OTYSNK9Q PGFRB_HUMAN Increases Phosphorylation [7]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Increases Cleavage [9]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Increases Expression [6]
Transcriptional activator Myb (MYB) OTJH64IV MYB_HUMAN Affects Localization [13]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Decreases Expression [7]
cAMP-dependent protein kinase type I-alpha regulatory subunit (PRKAR1A) OT589JA2 KAP0_HUMAN Increases Expression [6]
Retinoic acid receptor beta (RARB) OT367U3E RARB_HUMAN Increases Expression [6]
Lysosome-associated membrane glycoprotein 2 (LAMP2) OTLUGEJC LAMP2_HUMAN Affects Expression [6]
G2/mitotic-specific cyclin-B1 (CCNB1) OT19S7E5 CCNB1_HUMAN Decreases Expression [14]
Matrix metalloproteinase-9 (MMP9) OTB2QDAV MMP9_HUMAN Affects Expression [6]
Fatty acid-binding protein, adipocyte (FABP4) OT3DKFOU FABP4_HUMAN Affects Expression [6]
Ezrin (EZR) OTHBPF1Z EZRI_HUMAN Increases Expression [6]
Nucleoside diphosphate kinase A (NME1) OT0NELQ1 NDKA_HUMAN Decreases Expression [6]
CD44 antigen (CD44) OT9TTJ41 CD44_HUMAN Increases Expression [6]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Increases Expression [15]
Cytotoxic T-lymphocyte protein 4 (CTLA4) OTYQR611 CTLA4_HUMAN Increases Expression [6]
Transcription factor JunD (JUND) OTNKACJD JUND_HUMAN Increases Expression [6]
Early growth response protein 1 (EGR1) OTCP6XGZ EGR1_HUMAN Affects Expression [6]
Transcription factor E3 (TFE3) OTM99ZWH TFE3_HUMAN Affects Expression [6]
Lamin-B1 (LMNB1) OT100T3P LMNB1_HUMAN Increases Cleavage [11]
Ephrin type-A receptor 1 (EPHA1) OTGJMRZ0 EPHA1_HUMAN Increases Phosphorylation [7]
Fibroblast growth factor receptor 2 (FGFR2) OTLOPACK FGFR2_HUMAN Decreases Phosphorylation [7]
B-cell differentiation antigen CD72 (CD72) OTPOJID2 CD72_HUMAN Decreases Expression [6]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Decreases Expression [9]
Tyrosine-protein phosphatase non-receptor type 6 (PTPN6) OT33XNZM PTN6_HUMAN Decreases Expression [6]
G1/S-specific cyclin-D2 (CCND2) OTDULQF9 CCND2_HUMAN Decreases Expression [9]
M-phase inducer phosphatase 3 (CDC25C) OTPQI71S MPIP3_HUMAN Decreases Expression [16]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Decreases Phosphorylation [9]
RAC-beta serine/threonine-protein kinase (AKT2) OTBB632K AKT2_HUMAN Decreases Phosphorylation [17]
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (MAN1A1) OT6LIGJP MA1A1_HUMAN Increases Expression [6]
Tyrosine-protein kinase RYK (RYK) OTZ3WWZH RYK_HUMAN Decreases Phosphorylation [7]
Catenin beta-1 (CTNNB1) OTZ932A3 CTNB1_HUMAN Decreases Phosphorylation [7]
DNA damage-inducible transcript 3 protein (DDIT3) OTI8YKKE DDIT3_HUMAN Increases Expression [6]
Vascular endothelial growth factor receptor 2 (KDR) OT15797V VGFR2_HUMAN Decreases Phosphorylation [7]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Increases Expression [6]
Interleukin-6 receptor subunit beta (IL6ST) OT1N9C70 IL6RB_HUMAN Increases Expression [6]
Signal transducer and activator of transcription 3 (STAT3) OTAAGKYZ STAT3_HUMAN Decreases Phosphorylation [7]
ETS translocation variant 5 (ETV5) OTE2OBM4 ETV5_HUMAN Increases Expression [6]
Regulator of G-protein signaling 2 (RGS2) OT0FSRW7 RGS2_HUMAN Increases Expression [6]
Protein kinase C iota type (PRKCI) OTKBAVT3 KPCI_HUMAN Increases Expression [6]
Serine/threonine-protein kinase mTOR (MTOR) OTHH8KU7 MTOR_HUMAN Decreases Phosphorylation [9]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Increases Activity [10]
Tyrosine-protein kinase FRK (FRK) OTEKV1SC FRK_HUMAN Increases Phosphorylation [7]
Nuclear receptor subfamily 4 group A member 2 (NR4A2) OT3F9IR2 NR4A2_HUMAN Increases Expression [6]
Tyrosine-protein kinase SYK (SYK) OTQID87L KSYK_HUMAN Increases Phosphorylation [7]
Mitogen-activated protein kinase 9 (MAPK9) OTCEVJ9E MK09_HUMAN Increases Phosphorylation [7]
Ran GTPase-activating protein 1 (RANGAP1) OTZGD3LJ RAGP1_HUMAN Increases Phosphorylation [18]
Crk-like protein (CRKL) OTOYSD1R CRKL_HUMAN Decreases Phosphorylation [19]
Glioma pathogenesis-related protein 1 (GLIPR1) OT0FGQK7 GLIP1_HUMAN Increases Expression [6]
Max-interacting protein 1 (MXI1) OTUQ9E0D MXI1_HUMAN Increases Expression [6]
Tyrosine-protein kinase Blk (BLK) OT1EB8MT BLK_HUMAN Increases Phosphorylation [7]
Protein FosB (FOSB) OTW6C05J FOSB_HUMAN Decreases Expression [6]
Epithelial membrane protein 1 (EMP1) OTSZHUHQ EMP1_HUMAN Increases Expression [6]
Caspase-7 (CASP7) OTAPJ040 CASP7_HUMAN Increases Activity [10]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Increases Cleavage [9]
BH3-interacting domain death agonist (BID) OTOSHSHU BID_HUMAN Decreases Expression [9]
Claudin-15 (CLDN15) OT9K0KI7 CLD15_HUMAN Affects Expression [6]
Leukocyte immunoglobulin-like receptor subfamily A member 4 (LILRA4) OTKC3PA6 LIRA4_HUMAN Decreases Expression [6]
Actin, cytoplasmic 1 (ACTB) OT1MCP2F ACTB_HUMAN Increases Expression [6]
Rho-related GTP-binding protein RhoB (RHOB) OTHQFQF7 RHOB_HUMAN Increases Expression [6]
Small ribosomal subunit protein eS6 (RPS6) OTT4D1LN RS6_HUMAN Decreases Phosphorylation [20]
Actin, cytoplasmic 2 (ACTG1) OTH4V7VQ ACTG_HUMAN Increases Expression [6]
Tropomyosin alpha-4 chain (TPM4) OTN4YLYR TPM4_HUMAN Increases Expression [6]
Histone H3.3 (H3-3B) OT9XHQ3C H33_HUMAN Increases Expression [6]
DNA-binding protein inhibitor ID-2 (ID2) OT0U1D53 ID2_HUMAN Increases Expression [6]
Angiopoietin-1 receptor (TEK) OT78YN57 TIE2_HUMAN Decreases Phosphorylation [7]
cAMP-responsive element modulator (CREM) OTJIJ5AL CREM_HUMAN Increases Expression [6]
Histone-lysine N-methyltransferase 2A (KMT2A) OT9GLJI6 KMT2A_HUMAN Increases Expression [6]
Dual specificity protein phosphatase 2 (DUSP2) OTH54FMR DUS2_HUMAN Decreases Expression [6]
3',5'-cyclic-AMP phosphodiesterase 4B (PDE4B) OTOA8WU2 PDE4B_HUMAN Increases Expression [6]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Decreases Expression [9]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) OT2YYI1A MCL1_HUMAN Decreases Expression [9]
Son of sevenless homolog 2 (SOS2) OTV3XRE5 SOS2_HUMAN Increases Expression [6]
Forkhead box protein O1 (FOXO1) OTPJRB6D FOXO1_HUMAN Affects Phosphorylation [9]
Inositol 1,4,5-triphosphate receptor associated 2 (IRAG2) OTLUTKJQ IRAG2_HUMAN Affects Expression [6]
Dual specificity protein phosphatase 4 (DUSP4) OT6WAO12 DUS4_HUMAN Increases Expression [6]
Non-receptor tyrosine-protein kinase TNK1 (TNK1) OTXG5RWQ TNK1_HUMAN Increases Phosphorylation [7]
Sequestosome-1 (SQSTM1) OTGY5D5J SQSTM_HUMAN Affects Expression [6]
Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1) OTHBQVD5 4EBP1_HUMAN Decreases Phosphorylation [9]
Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1) OTXEE550 APR_HUMAN Increases Expression [6]
Krueppel-like factor 5 (KLF5) OT1ABI9N KLF5_HUMAN Increases Expression [6]
Protein-tyrosine kinase 2-beta (PTK2B) OTGAS0I8 FAK2_HUMAN Increases Phosphorylation [7]
Genetic suppressor element 1 (GSE1) OT3J7CJB GSE1_HUMAN Affects Expression [6]
Nuclear mitotic apparatus protein 1 (NUMA1) OTTKAVG4 NUMA1_HUMAN Affects Localization [21]
Astrocytic phosphoprotein PEA-15 (PEA15) OTKCKTSX PEA15_HUMAN Increases Expression [6]
Interferon regulatory factor 4 (IRF4) OT1DHQ1P IRF4_HUMAN Affects Expression [6]
Microtubule-associated protein RP/EB family member 1 (MAPRE1) OTCVQD60 MARE1_HUMAN Affects Localization [21]
Exostosin-1 (EXT1) OTRPALJK EXT1_HUMAN Increases Expression [6]
Serine/arginine-rich splicing factor 7 (SRSF7) OTRS4W4S SRSF7_HUMAN Increases Expression [6]
Pleckstrin homology-like domain family A member 2 (PHLDA2) OTMV9DPP PHLA2_HUMAN Increases Expression [6]
Muscleblind-like protein 2 (MBNL2) OTF7CF1F MBNL2_HUMAN Increases Expression [6]
Histone H2A.V (H2AZ2) OT0I5H2P H2AV_HUMAN Increases Expression [6]
Syntaxin-12 (STX12) OT5IBQ62 STX12_HUMAN Increases Expression [6]
Polycomb group protein ASXL1 (ASXL1) OTX931AW ASXL1_HUMAN Increases Expression [6]
DDB1- and CUL4-associated factor 11 (DCAF11) OTNSGYK1 DCA11_HUMAN Increases Expression [6]
Protein NDRG1 (NDRG1) OTVO66BO NDRG1_HUMAN Increases Expression [6]
Estrogen receptor beta (ESR2) OTXNR2WQ ESR2_HUMAN Increases Expression [6]
TRAF family member-associated NF-kappa-B activator (TANK) OTZSGFIK TANK_HUMAN Increases Expression [6]
Proline-rich AKT1 substrate 1 (AKT1S1) OT4JHN4Y AKTS1_HUMAN Decreases Phosphorylation [15]
MAP/microtubule affinity-regulating kinase 4 (MARK4) OT6Z2TGV MARK4_HUMAN Increases Expression [6]
Tribbles homolog 1 (TRIB1) OTPEO17G TRIB1_HUMAN Increases Expression [6]
Krueppel-like factor 6 (KLF6) OTQY9S7F KLF6_HUMAN Increases Expression [6]
Mitogen-activated protein kinase kinase kinase 3 (MAP3K3) OT53LJGW M3K3_HUMAN Affects Expression [6]
Calsyntenin-3 (CLSTN3) OTPUFK4C CSTN3_HUMAN Affects Expression [6]
Reticulon-4 (RTN4) OTIH85O3 RTN4_HUMAN Affects Expression [6]
DNA damage-inducible transcript 4 protein (DDIT4) OTHY8SY4 DDIT4_HUMAN Increases Expression [6]
Bcl-2-associated transcription factor 1 (BCLAF1) OT7T8H6A BCLF1_HUMAN Increases Expression [6]
Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3) OT0DZGY4 E2AK3_HUMAN Increases Expression [6]
ADP-ribosylation factor-binding protein GGA2 (GGA2) OT43HO27 GGA2_HUMAN Increases Expression [6]
F-box only protein 2 (FBXO2) OTF3677S FBX2_HUMAN Affects Expression [6]
Transcription factor MafF (MAFF) OT9B7MX0 MAFF_HUMAN Increases Expression [6]
Disheveled-associated activator of morphogenesis 1 (DAAM1) OT0VHIYZ DAAM1_HUMAN Increases Expression [6]
TNF receptor-associated factor 6 (TRAF6) OTA5GO5K TRAF6_HUMAN Affects Localization [13]
Krueppel-like factor 12 (KLF12) OTVH4KD4 KLF12_HUMAN Increases Expression [6]
Dual specificity protein phosphatase 10 (DUSP10) OTNG467B DUS10_HUMAN Increases Expression [6]
Cyclic AMP-dependent transcription factor ATF-3 (ATF3) OTC1UOHP ATF3_HUMAN Increases Response To Substance [6]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Affects Response To Substance [20]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA) OTTOMI8J PK3CA_HUMAN Affects Response To Substance [20]
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⏷ Show the Full List of 143 DOT(s)
Indication(s) of Azacitidine
Disease Entry ICD 11 Status REF
Acute myelogenous leukaemia 2A41 Approved [4]
Chronic myelomonocytic leukemia N.A. Approved [4]
Leukemia N.A. Approved [4]
Myelodysplastic syndrome 2A37 Approved [5]
Myeloproliferative neoplasm 2A20 Approved [4]
Plasma cell myeloma 2A83.1 Approved [4]
Azacitidine Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
DNA [cytosine-5]-methyltransferase (DNMT) TTHVCUP NOUNIPROTAC Inhibitor [26]
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Azacitidine Interacts with 2 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytidine aminohydrolase (CDA) DEKEDRC CDD_HUMAN Metabolism [27]
Cytidine deaminase (cdd) DEYILK4 E0TLJ6_MYCHH Metabolism [28]
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Azacitidine Interacts with 275 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Affects Expression [29]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Increases Expression [30]
Cytochrome P450 1A2 (CYP1A2) OTLLBX48 CP1A2_HUMAN Increases Expression [30]
Aryl hydrocarbon receptor (AHR) OTFE4EYE AHR_HUMAN Increases Expression [30]
Cytochrome P450 1B1 (CYP1B1) OTYXFLSD CP1B1_HUMAN Increases Expression [30]
Sulfotransferase 1C2 (SULT1C2) OT07MMZS ST1C2_HUMAN Increases Expression [22]
Phospholipid phosphatase 1 (PLPP1) OT0IIMI5 PLPP1_HUMAN Increases Expression [22]
Tectonin beta-propeller repeat-containing protein 2 (TECPR2) OT1UFECZ TCPR2_HUMAN Increases Expression [22]
TBC1 domain family member 4 (TBC1D4) OTK66C40 TBCD4_HUMAN Decreases Expression [22]
Multiple epidermal growth factor-like domains protein 6 (MEGF6) OTEUYTP1 MEGF6_HUMAN Decreases Expression [22]
Stanniocalcin-2 (STC2) OT86YP8G STC2_HUMAN Decreases Expression [22]
Integrin beta-2 (ITGB2) OTEKPEPR ITB2_HUMAN Decreases Expression [22]
Protein S100-A9 (S100A9) OTOARHCS S10A9_HUMAN Increases Expression [22]
Receptor-type tyrosine-protein phosphatase C (PTPRC) OT6KOR77 PTPRC_HUMAN Increases Expression [22]
Delta-aminolevulinic acid dehydratase (ALAD) OTHM9GSH HEM2_HUMAN Decreases Expression [22]
Hepatocyte growth factor (HGF) OTGHUA23 HGF_HUMAN Increases Expression [22]
Heat shock 70 kDa protein 6 (HSPA6) OTH4S7WB HSP76_HUMAN Increases Expression [22]
Gamma-aminobutyric acid receptor subunit beta-1 (GABRB1) OT4L2SSB GBRB1_HUMAN Increases Expression [22]
Transcription factor E3 (TFE3) OTM99ZWH TFE3_HUMAN Increases Expression [22]
Pro-thyrotropin-releasing hormone (TRH) OT02UY2V TRH_HUMAN Decreases Expression [22]
Protein S100-P (S100P) OTJCXNJG S100P_HUMAN Increases Expression [22]
Protein PML (PML) OT6SM2GD PML_HUMAN Increases Expression [22]
DNA-binding protein inhibitor ID-1 (ID1) OTKGNZN5 ID1_HUMAN Increases Expression [22]
Cyclin-dependent kinase 4 inhibitor B (CDKN2B) OTAG24N1 CDN2B_HUMAN Decreases Methylation [22]
LIM and senescent cell antigen-like-containing domain protein 1 (LIMS1) OT729S0T LIMS1_HUMAN Increases Expression [22]
E3 SUMO-protein ligase RanBP2 (RANBP2) OTFG5CVF RBP2_HUMAN Increases Expression [22]
Cyclin-dependent kinase inhibitor 1C (CDKN1C) OTASTJ3Q CDN1C_HUMAN Increases Expression [22]
Ras-related protein Rab-13 (RAB13) OTIQ484I RAB13_HUMAN Decreases Methylation [22]
Lysozyme C (LYZ) OTD7H0G6 LYSC_HUMAN Increases Expression [22]
Claudin-10 (CLDN10) OT2CVAKY CLD10_HUMAN Decreases Expression [22]
Sushi repeat-containing protein SRPX (SRPX) OT5B9LXS SRPX_HUMAN Decreases Expression [22]
Protein delta homolog 1 (DLK1) OTE1VLNB DLK1_HUMAN Decreases Methylation [22]
DNA-binding protein inhibitor ID-3 (ID3) OTUULW5Z ID3_HUMAN Increases Expression [22]
Collagen alpha-1(XIV) chain (COL14A1) OTLNJ13O COEA1_HUMAN Increases Expression [22]
Equilibrative nucleoside transporter 2 (SLC29A2) OTUAOB8T S29A2_HUMAN Decreases Expression [22]
Cytohesin-1 (CYTH1) OTYH9NRJ CYH1_HUMAN Increases Expression [22]
C3a anaphylatoxin chemotactic receptor (C3AR1) OT8J0TF8 C3AR_HUMAN Increases Expression [22]
DNA dC->dU-editing enzyme APOBEC-3F (APOBEC3F) OT750IJM ABC3F_HUMAN Increases Expression [22]
Angiogenic factor with G patch and FHA domains 1 (AGGF1) OTA7U2T8 AGGF1_HUMAN Increases Expression [22]
E3 ubiquitin-protein ligase Praja-1 (PJA1) OTFKTMEI PJA1_HUMAN Increases Expression [22]
Caspase-10 (CASP10) OTE6J88E CASPA_HUMAN Increases Expression [22]
Tetraspanin-32 (TSPAN32) OTSXW7EW TSN32_HUMAN Decreases Expression [22]
Tribbles homolog 1 (TRIB1) OTPEO17G TRIB1_HUMAN Decreases Expression [22]
Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LITAF) OTT5JX1F LITAF_HUMAN Decreases Expression [22]
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1A) OTVTB5R5 PI51A_HUMAN Decreases Expression [22]
Centromere protein O (CENPO) OTXAH83Y CENPO_HUMAN Increases Expression [22]
Iron-sulfur cluster assembly 1 homolog, mitochondrial (ISCA1) OTU230MC ISCA1_HUMAN Increases Expression [22]
E3 ubiquitin-protein ligase TRIM8 (TRIM8) OTS6JFR0 TRIM8_HUMAN Increases Expression [22]
Uncharacterized protein C6orf62 (C6ORF62) OTGK4G35 CF062_HUMAN Increases Expression [22]
Metal transporter CNNM2 (CNNM2) OTZHO8WU CNNM2_HUMAN Decreases Expression [22]
Pantothenate kinase 3 (PANK3) OT77CFJ6 PANK3_HUMAN Decreases Expression [22]
DNA dC->dU-editing enzyme APOBEC-3G (APOBEC3G) OT410VP5 ABC3G_HUMAN Increases Expression [22]
Neuritin (NRN1) OTWJG0SO NRN1_HUMAN Decreases Expression [22]
NTF2-related export protein 2 (NXT2) OTK82YVT NXT2_HUMAN Increases Expression [22]
THUMP domain-containing protein 1 (THUMPD1) OTKU8KWH THUM1_HUMAN Increases Expression [22]
Protein FAM8A1 (FAM8A1) OT1QVTGS FA8A1_HUMAN Increases Expression [22]
Type 2 lactosamine alpha-2,3-sialyltransferase (ST3GAL6) OTB17Q43 SIA10_HUMAN Increases Expression [22]
Methionine-R-sulfoxide reductase B2, mitochondrial (MSRB2) OTURGRA8 MSRB2_HUMAN Increases Expression [22]
Mitotic spindle assembly checkpoint protein MAD1 (MAD1L1) OTJCX8K9 MD1L1_HUMAN Decreases Expression [22]
Signal-regulatory protein beta-1 (SIRPB1) OTGHALWJ SIRB1_HUMAN Decreases Expression [23]
Syntenin-1 (SDCBP) OTS3NCC5 SDCB1_HUMAN Decreases Expression [23]
Complexin-1 (CPLX1) OT7UIGTP CPLX1_HUMAN Increases Expression [23]
Nephrocystin-1 (NPHP1) OTZHCFFQ NPHP1_HUMAN Increases Expression [23]
Phosphatase and actin regulator 2 (PHACTR2) OTWMX2A8 PHAR2_HUMAN Increases Expression [23]
Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1) OT4TMERS NFAC1_HUMAN Increases Expression [23]
Acyl-CoA 6-desaturase (FADS2) OTUX531P FADS2_HUMAN Decreases Expression [23]
Metalloproteinase inhibitor 1 (TIMP1) OTOXC51H TIMP1_HUMAN Increases Expression [23]
Cystatin-C (CST3) OTNZ6AO4 CYTC_HUMAN Increases Expression [23]
Cystatin-S (CST4) OTXXM8EH CYTS_HUMAN Increases Expression [23]
Interstitial collagenase (MMP1) OTI4I2V1 MMP1_HUMAN Increases Expression [23]
Integrin beta-1 (ITGB1) OT6G1IAR ITB1_HUMAN Decreases Expression [23]
Keratin, type II cytoskeletal 8 (KRT8) OTTM4X11 K2C8_HUMAN Increases Expression [23]
Neurofilament light polypeptide (NEFL) OTQESJV4 NFL_HUMAN Increases Expression [23]
Protein disulfide-isomerase (P4HB) OTTYNYPF PDIA1_HUMAN Increases Expression [23]
Decorin (DCN) OTWLJL7K PGS2_HUMAN Decreases Expression [23]
Profilin-1 (PFN1) OTHTGA1H PROF1_HUMAN Increases Expression [23]
Proto-oncogene tyrosine-protein kinase receptor Ret (RET) OTLU040A RET_HUMAN Decreases Expression [23]
Tropomyosin beta chain (TPM2) OTA1L0P8 TPM2_HUMAN Increases Expression [23]
Transcription factor Sp1 (SP1) OTISPT4X SP1_HUMAN Decreases Expression [23]
Keratin, type I cytoskeletal 19 (KRT19) OTDGDQ75 K1C19_HUMAN Increases Expression [23]
Insulin-like growth factor-binding protein 1 (IGFBP1) OT6UQV2K IBP1_HUMAN Increases Expression [23]
Small ribosomal subunit protein uS2 (RPSA) OTJZHEGT RSSA_HUMAN Decreases Expression [23]
Glycodelin (PAEP) OTQA0NV4 PAEP_HUMAN Decreases Expression [23]
E3 SUMO-protein ligase EGR2 (EGR2) OTAVQ78J EGR2_HUMAN Increases Expression [23]
Pregnancy-specific beta-1-glycoprotein 1 (PSG1) OT1U4ZZW PSG1_HUMAN Increases Expression [23]
Collagen alpha-3(VI) chain (COL6A3) OTAS6R6I CO6A3_HUMAN Decreases Expression [23]
Parathyroid hormone-related protein (PTHLH) OTI1JF13 PTHR_HUMAN Decreases Expression [23]
Plastin-3 (PLS3) OTYBM4PK PLST_HUMAN Decreases Expression [23]
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial (MTHFD2) OT1LQSGX MTDC_HUMAN Decreases Expression [23]
Pyruvate kinase PKM (PKM) OTLHHMC2 KPYM_HUMAN Increases Expression [23]
Carboxypeptidase E (CPE) OTXNTV79 CBPE_HUMAN Increases Expression [23]
High mobility group protein HMG-I/HMG-Y (HMGA1) OTQUSHPX HMGA1_HUMAN Increases Expression [23]
Gap junction alpha-1 protein (GJA1) OTT94MKL CXA1_HUMAN Decreases Expression [23]
Desmin (DES) OTI09KBW DESM_HUMAN Increases Expression [23]
Plasma membrane calcium-transporting ATPase 1 (ATP2B1) OT5MXG9W AT2B1_HUMAN Decreases Expression [23]
Cyclin-A2 (CCNA2) OTPHHYZJ CCNA2_HUMAN Decreases Expression [23]
5'-nucleotidase (NT5E) OT7J5LT6 5NTD_HUMAN Increases Expression [23]
Fibroblast growth factor 7 (FGF7) OTGK6ANL FGF7_HUMAN Decreases Expression [23]
Insulin-like growth factor-binding protein 4 (IGFBP4) OT2HZRBD IBP4_HUMAN Increases Expression [23]
Transcription elongation factor A protein 1 (TCEA1) OTBFO594 TCEA1_HUMAN Decreases Expression [23]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Increases Expression [23]
Tenascin (TNC) OTK4FSHR TENA_HUMAN Decreases Expression [23]
V-type proton ATPase 16 kDa proteolipid subunit c (ATP6V0C) OTKPL09B VATL_HUMAN Increases Expression [23]
Protein ITPRID2 (ITPRID2) OTO3JDX5 ITPI2_HUMAN Increases Expression [23]
Dual specificity protein phosphatase 1 (DUSP1) OTN6BR75 DUS1_HUMAN Increases Expression [23]
Interleukin-12 subunit beta (IL12B) OT0JF8A3 IL12B_HUMAN Increases Expression [23]
Neurotensin/neuromedin N (NTS) OTPGDNQS NEUT_HUMAN Decreases Expression [23]
Guanylate-binding protein 2 (GBP2) OTVU4G07 GBP2_HUMAN Decreases Expression [23]
MHC class II transactivator (CIITA) OTRJNZFO C2TA_HUMAN Increases Expression [23]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Increases Expression [23]
Exosome RNA helicase MTR4 (MTREX) OTSQY30V MTREX_HUMAN Increases Expression [23]
Alpha-S1-casein (CSN1S1) OTXOW6XJ CASA1_HUMAN Increases Expression [23]
Nuclear receptor-interacting protein 1 (NRIP1) OTIZOJQV NRIP1_HUMAN Decreases Expression [23]
Homeobox protein Hox-A1 (HOXA1) OTMSOJ7D HXA1_HUMAN Increases Expression [23]
Ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1) OT6E2OW6 ENTP1_HUMAN Increases Expression [23]
Ephrin-A3 (EFNA3) OTJGOUMZ EFNA3_HUMAN Increases Expression [23]
GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 (ART1) OT7FBG5W NAR1_HUMAN Increases Expression [23]
Branched-chain-amino-acid aminotransferase, cytosolic (BCAT1) OTYHXLWZ BCAT1_HUMAN Decreases Expression [23]
Microfibrillar-associated protein 2 (MFAP2) OTMHVBTV MFAP2_HUMAN Decreases Expression [23]
Laminin subunit beta-2 (LAMB2) OT71OI2Y LAMB2_HUMAN Increases Expression [23]
NHP2-like protein 1 (SNU13) OTH56TIH NH2L1_HUMAN Increases Expression [23]
Homeobox protein DLX-6 (DLX6) OT0FIJHY DLX6_HUMAN Increases Expression [23]
Neurotrypsin (PRSS12) OT1MYL3L NETR_HUMAN Decreases Expression [23]
Elongation factor 1-alpha 1 (EEF1A1) OT00THXS EF1A1_HUMAN Decreases Expression [23]
Microtubule-associated protein 1A (MAP1A) OTHO8K43 MAP1A_HUMAN Decreases Expression [23]
E3 ubiquitin-protein ligase Mdm2 (MDM2) OTOVXARF MDM2_HUMAN Increases Expression [23]
Cytochrome c oxidase subunit 6A2, mitochondrial (COX6A2) OTQR5SXD CX6A2_HUMAN Increases Expression [23]
cAMP-responsive element modulator (CREM) OTJIJ5AL CREM_HUMAN Decreases Expression [23]
Caldesmon (CALD1) OTNJKJ6Q CALD1_HUMAN Increases Expression [23]
ATP-dependent RNA helicase A (DHX9) OT5AAOQI DHX9_HUMAN Decreases Expression [23]
Serine/threonine-protein kinase PAK 1 (PAK1) OT17LZNZ PAK1_HUMAN Increases Expression [23]
Dual specificity mitogen-activated protein kinase kinase 5 (MAP2K5) OT6T408U MP2K5_HUMAN Decreases Expression [23]
Chitotriosidase-1 (CHIT1) OTPQR0A6 CHIT1_HUMAN Increases Expression [23]
Ras and Rab interactor 1 (RIN1) OTPBROUD RIN1_HUMAN Increases Expression [23]
Keratin, type I cuticular Ha2 (KRT32) OTZCGZYT K1H2_HUMAN Increases Expression [23]
Semaphorin-3A (SEMA3A) OTQJSV7W SEM3A_HUMAN Increases Expression [23]
Ras GTPase-activating protein 3 (RASA3) OT9C54MN RASA3_HUMAN Increases Expression [23]
Mediator of DNA damage checkpoint protein 1 (MDC1) OTEUQH4J MDC1_HUMAN Increases Expression [23]
Transmembrane glycoprotein NMB (GPNMB) OTB7KQKV GPNMB_HUMAN Decreases Expression [23]
Mortality factor 4-like protein 2 (MORF4L2) OT8OI3EC MO4L2_HUMAN Decreases Expression [23]
kinase isozyme 1, mitochondrial (PDK1) OTMABK9Z PDK1_HUMAN Increases Expression [23]
Serine/threonine-protein kinase 38 (STK38) OTKMYCYR STK38_HUMAN Decreases Expression [23]
Serine/threonine-protein phosphatase 2A activator (PTPA) OTRGFOI7 PTPA_HUMAN Increases Expression [23]
Reticulocalbin-1 (RCN1) OT3JBGAG RCN1_HUMAN Decreases Expression [23]
Olfactory receptor 8B8 (OR8B8) OTCISNYV OR8B8_HUMAN Increases Expression [23]
Leukotriene B4 receptor 1 (LTB4R) OT3SRH4H LT4R1_HUMAN Decreases Expression [23]
Serine/arginine-rich splicing factor 7 (SRSF7) OTRS4W4S SRSF7_HUMAN Decreases Expression [23]
Guanylate kinase (GUK1) OTLI0HRU KGUA_HUMAN Increases Expression [23]
Filamin A-interacting protein 1-like (FILIP1L) OTPY8IMS FIL1L_HUMAN Decreases Expression [23]
Nucleolar MIF4G domain-containing protein 1 (NOM1) OTWZSJJC NOM1_HUMAN Decreases Expression [23]
Opioid growth factor receptor-like protein 1 (OGFRL1) OT6QGBYE OGRL1_HUMAN Increases Expression [23]
Serine/threonine-protein kinase MRCK alpha (CDC42BPA) OTCPFOSA MRCKA_HUMAN Decreases Expression [23]
Extracellular sulfatase Sulf-1 (SULF1) OTJCNCO0 SULF1_HUMAN Decreases Expression [23]
N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase (GCNT2) OTRUIMC4 GNT2A_HUMAN Decreases Expression [23]
Oxidation resistance protein 1 (OXR1) OTPIDMT3 OXR1_HUMAN Increases Expression [23]
Alpha-2,8-sialyltransferase 8B (ST8SIA2) OTRBBBD8 SIA8B_HUMAN Decreases Expression [23]
Type II iodothyronine deiodinase (DIO2) OTGPNSLH IOD2_HUMAN Decreases Expression [23]
G-patch domain and KOW motifs-containing protein (GPKOW) OTGS3H0M GPKOW_HUMAN Increases Expression [23]
Rho guanine nucleotide exchange factor 2 (ARHGEF2) OTBQTFRT ARHG2_HUMAN Decreases Expression [23]
Homogentisate 1,2-dioxygenase (HGD) OTTKLQOO HGD_HUMAN Increases Expression [23]
Secretory carrier-associated membrane protein 4 (SCAMP4) OTSCZTJ5 SCAM4_HUMAN Increases Expression [23]
Protein bicaudal D homolog 1 (BICD1) OT78IYPF BICD1_HUMAN Decreases Expression [23]
Ankyrin repeat and SOCS box protein 2 (ASB2) OTF9LV7L ASB2_HUMAN Increases Expression [23]
Eyes absent homolog 1 (EYA1) OTHU807A EYA1_HUMAN Decreases Expression [23]
Bcl-2-like protein 13 (BCL2L13) OT2VRFTM B2L13_HUMAN Increases Expression [23]
RNA helicase Mov10l1 (MOV10L1) OTP978LK M10L1_HUMAN Increases Expression [23]
Rac GTPase-activating protein 1 (RACGAP1) OTQE8IEH RGAP1_HUMAN Increases Expression [23]
Ras-related protein Rab-1B (RAB1B) OTAFCUAS RAB1B_HUMAN Increases Expression [23]
Semaphorin-6C (SEMA6C) OT1N59T5 SEM6C_HUMAN Increases Expression [23]
Sentrin-specific protease 3 (SENP3) OTFQDOMC SENP3_HUMAN Increases Expression [23]
Ribonuclease P protein subunit p21 (RPP21) OT53MDNE RPP21_HUMAN Increases Expression [23]
Protocadherin-18 (PCDH18) OTTLQWRN PCD18_HUMAN Decreases Expression [23]
Protein S100-A14 (S100A14) OTVFJJ91 S10AE_HUMAN Decreases Expression [23]
Tryptase gamma (TPSG1) OTDESHKT TRYG1_HUMAN Decreases Expression [23]
Rho GTPase-activating protein 35 (ARHGAP35) OTJ8POG0 RHG35_HUMAN Increases Expression [23]
Neuroligin-3 (NLGN3) OTKDEC1Q NLGN3_HUMAN Increases Expression [23]
Polycystin-2-like protein 1 (PKD2L1) OT1KJDAT PK2L1_HUMAN Increases Expression [23]
A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1) OTTLJH8W ATS1_HUMAN Decreases Expression [23]
Cytoplasmic phosphatidylinositol transfer protein 1 (PITPNC1) OT64TTGC PITC1_HUMAN Decreases Expression [23]
Transcription factor SOX-13 (SOX13) OTCIF6KC SOX13_HUMAN Decreases Expression [23]
Afadin- and alpha-actinin-binding protein (SSX2IP) OTEIZ7N1 ADIP_HUMAN Increases Expression [23]
Transmembrane emp24 domain-containing protein 3 (TMED3) OTNOPHHC TMED3_HUMAN Increases Expression [23]
Protocadherin beta-4 (PCDHB4) OTF665E0 PCDB4_HUMAN Decreases Expression [23]
Protocadherin beta-14 (PCDHB14) OTFZF1ST PCDBE_HUMAN Decreases Expression [23]
Adenylate kinase isoenzyme 5 (AK5) OTTGXLOT KAD5_HUMAN Increases Expression [23]
Albumin (ALB) OTVMM513 ALBU_HUMAN Increases Expression [31]
Alpha-fetoprotein (AFP) OT9GG3ZI FETA_HUMAN Increases Expression [31]
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Increases Expression [31]
Tyrosine aminotransferase (TAT) OT2CJ91O ATTY_HUMAN Increases Expression [31]
Hepatocyte nuclear factor 4-alpha (HNF4A) OTY1TOAB HNF4A_HUMAN Increases Expression [31]
CCAAT/enhancer-binding protein alpha (CEBPA) OTOM9OE4 CEBPA_HUMAN Increases Expression [31]
Hematopoietically-expressed homeobox protein HHEX (HHEX) OTLIUVYX HHEX_HUMAN Increases Expression [31]
Suppressor of cytokine signaling 3 (SOCS3) OTY183WJ SOCS3_HUMAN Affects Expression [29]
Telomerase reverse transcriptase (TERT) OT085VVA TERT_HUMAN Decreases Expression [32]
Aquaporin-9 (AQP9) OTLGH5ZY AQP9_HUMAN Increases Expression [33]
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 (GNG7) OTHS1L0E GBG7_HUMAN Affects Methylation [34]
Claudin-7 (CLDN7) OTNE0XHQ CLD7_HUMAN Decreases Expression [35]
Claudin-9 (CLDN9) OTCKI2IZ CLD9_HUMAN Increases Expression [36]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Decreases Expression [32]
Calcitonin (CALCA) OTZ11LHB CALC_HUMAN Decreases Methylation [37]
Tumor necrosis factor (TNF) OT4IE164 TNFA_HUMAN Increases Response To Substance [38]
Estrogen receptor (ESR1) OTKLU61J ESR1_HUMAN Increases Expression [39]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Affects Activity [40]
Interleukin-4 (IL4) OTOXBWAU IL4_HUMAN Affects Methylation [41]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Affects Methylation [41]
Tyrosine-protein kinase Fyn (FYN) OTLSLVZS FYN_HUMAN Increases Expression [42]
Cyclin-dependent kinase 1 (CDK1) OTW1SC2N CDK1_HUMAN Increases Expression [43]
L-lactate dehydrogenase B chain (LDHB) OT9B1CT3 LDHB_HUMAN Increases Expression [44]
Thyroid peroxidase (TPO) OTJJLL20 PERT_HUMAN Increases Expression [45]
Prostate-specific antigen (KLK3) OTFGSBFJ KLK3_HUMAN Increases Expression [43]
Histone H1.0 (H1-0) OTRLJK4Z H10_HUMAN Increases Expression [46]
Interleukin-6 receptor subunit alpha (IL6R) OTCQL07Z IL6RA_HUMAN Affects Expression [29]
Gamma-enolase (ENO2) OTRODL0T ENOG_HUMAN Decreases Expression [47]
Androgen receptor (AR) OTUBKAZZ ANDR_HUMAN Increases Expression [43]
Microtubule-associated protein tau (MAPT) OTMTP2Z7 TAU_HUMAN Decreases Expression [48]
Chromogranin-A (CHGA) OTXYX5JH CMGA_HUMAN Decreases Expression [47]
Cyclin-dependent kinase 4 (CDK4) OT7EP05T CDK4_HUMAN Decreases Expression [43]
Cadherin-1 (CDH1) OTFJMXPM CADH1_HUMAN Increases Expression [49]
G2/mitotic-specific cyclin-B1 (CCNB1) OT19S7E5 CCNB1_HUMAN Increases Expression [47]
15-hydroxyprostaglandin dehydrogenase (HPGD) OTYZI6JB PGDH_HUMAN Decreases Methylation [50]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Increases Expression [51]
Methylated-DNA--protein-cysteine methyltransferase (MGMT) OT40A9WH MGMT_HUMAN Increases Expression [52]
Thyrotropin receptor (TSHR) OT0BC8LB TSHR_HUMAN Increases Expression [45]
Hepatocyte nuclear factor 1-alpha (HNF1A) OT9DOUKL HNF1A_HUMAN Increases Expression [33]
Fibulin-1 (FBLN1) OT5MHHOP FBLN1_HUMAN Increases Expression [42]
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A) OTDRV63V GA45A_HUMAN Increases Expression [53]
Cyclin-dependent kinase 2 (CDK2) OTB5DYYZ CDK2_HUMAN Decreases Expression [43]
DNA cytosine-5)-methyltransferase 1 (DNMT1) OTM2DGTK DNMT1_HUMAN Decreases Expression [54]
G1/S-specific cyclin-D2 (CCND2) OTDULQF9 CCND2_HUMAN Affects Methylation [55]
Oxytocin receptor (OXTR) OT7WFW4U OXYR_HUMAN Decreases Expression [42]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Affects Expression [29]
Cyclin-dependent kinase inhibitor 2A (CDKN2A) OTN0ZWAE CDN2A_HUMAN Decreases Methylation [56]
Melanoma-associated antigen 1 (MAGEA1) OTXAO193 MAGA1_HUMAN Decreases Methylation [56]
Melanoma-associated antigen 3 (MAGEA3) OTW3Y5M4 MAGA3_HUMAN Increases Expression [57]
Killer cell immunoglobulin-like receptor 2DL1 (KIR2DL1) OTL1LBQJ KI2L1_HUMAN Increases Expression [58]
Killer cell immunoglobulin-like receptor 2DL2 (KIR2DL2) OTOVUTJD KI2L2_HUMAN Increases Expression [58]
Killer cell immunoglobulin-like receptor 2DL3 (KIR2DL3) OTFCN53B KI2L3_HUMAN Increases Expression [58]
Killer cell immunoglobulin-like receptor 3DL1 (KIR3DL1) OTPOSXFX KI3L1_HUMAN Increases Expression [58]
Killer cell immunoglobulin-like receptor 2DS4 (KIR2DS4) OT00N6UJ KI2S4_HUMAN Increases Expression [58]
Tumor necrosis factor ligand superfamily member 6 (FASLG) OTZARCHH TNFL6_HUMAN Increases Response To Substance [38]
Stromal cell-derived factor 1 (CXCL12) OT2QX5LL SDF1_HUMAN Increases Expression [59]
Tuberin (TSC2) OT47LWI9 TSC2_HUMAN Increases Expression [60]
Tumor necrosis factor ligand superfamily member 10 (TNFSF10) OT4PXBTA TNF10_HUMAN Increases Response To Substance [38]
High mobility group protein HMGI-C (HMGA2) OTBMBHHL HMGA2_HUMAN Increases Expression [42]
Homeobox protein Nkx-2.5 (NKX2-5) OTS1SAWM NKX25_HUMAN Increases Expression [61]
Death-associated protein kinase 1 (DAPK1) OTNCNUCO DAPK1_HUMAN Affects Methylation [62]
Claudin-6 (CLDN6) OTEN8ID2 CLD6_HUMAN Increases Expression [36]
Claudin-8 (CLDN8) OT7IIWXG CLD8_HUMAN Increases Expression [36]
Small ribosomal subunit protein eS6 (RPS6) OTT4D1LN RS6_HUMAN Decreases Phosphorylation [42]
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PPP2CA) OT83PT85 PP2AA_HUMAN Increases Expression [63]
Cyclin-A1 (CCNA1) OTX4HD45 CCNA1_HUMAN Decreases Expression [64]
Heat shock factor protein 1 (HSF1) OTYNJ4KP HSF1_HUMAN Decreases Activity [65]
Transcription factor p65 (RELA) OTUJP9CN TF65_HUMAN Affects Localization [29]
Tight junction protein ZO-1 (TJP1) OTBDCUPK ZO1_HUMAN Increases Expression [36]
Dihydropyrimidine dehydrogenase (DPYD) OTWRF2NR DPYD_HUMAN Decreases Methylation [66]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3) OT4SO7J4 BNIP3_HUMAN Increases Expression [67]
N-myc-interactor (NMI) OTYVG3NM NMI_HUMAN Increases Expression [42]
NAD(P) transhydrogenase, mitochondrial (NNT) OTAIOGZK NNTM_HUMAN Increases Expression [35]
Runt-related transcription factor 3 (RUNX3) OTITK1XD RUNX3_HUMAN Affects Methylation [68]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Increases Expression [69]
Cyclin-G2 (CCNG2) OTII38K2 CCNG2_HUMAN Decreases Expression [42]
Occludin (OCLN) OTSUTVWL OCLN_HUMAN Increases Expression [36]
kinase isozyme 4, mitochondrial (PDK4) OTCMHMBZ PDK4_HUMAN Decreases Methylation [70]
Dual specificity protein phosphatase 6 (DUSP6) OT4H6RKW DUS6_HUMAN Increases Expression [42]
Ribonucleoside-diphosphate reductase subunit M2 B (RRM2B) OTE8GBUR RIR2B_HUMAN Increases Expression [71]
Sodium/iodide cotransporter (SLC5A5) OTU7E9G7 SC5A5_HUMAN Increases Expression [72]
Krueppel-like factor 6 (KLF6) OTQY9S7F KLF6_HUMAN Increases Expression [42]
Killer cell immunoglobulin-like receptor 2DL4 (KIR2DL4) OTXN18OA KI2L4_HUMAN Increases Expression [58]
Protein Niban 1 (NIBAN1) OTYOLI12 NIBA1_HUMAN Increases Expression [42]
Calcium homeostasis modulator protein 2 (CALHM2) OTWWM6HI CAHM2_HUMAN Increases Expression [35]
Homeobox protein SIX2 (SIX2) OTYOVGSC SIX2_HUMAN Decreases Expression [35]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (PLCB1) OT9HYT7A PLCB1_HUMAN Increases Expression [73]
Sal-like protein 4 (SALL4) OTC08PR5 SALL4_HUMAN Affects Methylation [25]
Transcription factor MafB (MAFB) OTH2N3T8 MAFB_HUMAN Increases Expression [35]
Sodium/nucleoside cotransporter 1 (SLC28A1) OTXWVV9O S28A1_HUMAN Increases Response To Substance [74]
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References

1 ClinicalTrials.gov (NCT01926587) Phase II Part 2 Expansion of Oral Rigosertib in Combination With Azacitidine
2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7833).
4 Azacitidine FDA Label
5 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6796).
6 ON 01910.Na is selectively cytotoxic for chronic lymphocytic leukemia cells through a dual mechanism of action involving PI3K/AKT inhibition and induction of oxidative stress. Clin Cancer Res. 2012 Apr 1;18(7):1979-91. doi: 10.1158/1078-0432.CCR-11-2113. Epub 2012 Feb 20.
7 Rigosertib as a selective anti-tumor agent can ameliorate multiple dysregulated signaling transduction pathways in high-grade myelodysplastic syndrome. Sci Rep. 2014 Dec 4;4:7310. doi: 10.1038/srep07310.
8 Phase I study of oral rigosertib (ON 01910.Na), a dual inhibitor of the PI3K and Plk1 pathways, in adult patients with advanced solid malignancies. Clin Cancer Res. 2014 Mar 15;20(6):1656-65.
9 Styryl sulfonyl compounds inhibit translation of cyclin D1 in mantle cell lymphoma cells. Oncogene. 2009 Mar 26;28(12):1518-28. doi: 10.1038/onc.2008.502. Epub 2009 Feb 9.
10 Discovery of a clinical stage multi-kinase inhibitor sodium (E)-2-{2-methoxy-5-[(2',4',6'-trimethoxystyrylsulfonyl)methyl]phenylamino}acetate (ON 01910.Na): synthesis, structure-activity relationship, and biological activity. J Med Chem. 2011 Sep 22;54(18):6254-76. doi: 10.1021/jm200570p. Epub 2011 Aug 17.
11 Effect of ON 01910.Na, an anticancer mitotic inhibitor, on cell-cycle progression correlates with RanGAP1 hyperphosphorylation. Cancer Res. 2011 Jul 15;71(14):4968-76. doi: 10.1158/0008-5472.CAN-10-1603. Epub 2011 Jun 6.
12 Discontinuous drug binding to proteins: binding of an antineoplastic benzyl styryl sulfone to albumin and enzymes in vitro and in phase I clinical trials. Drug Metab Dispos. 2010 Sep;38(9):1480-5. doi: 10.1124/dmd.110.033001. Epub 2010 May 25.
13 ON 01910.Na inhibits growth of diffuse large B-cell lymphoma by cytoplasmic sequestration of sumoylated C-MYB/TRAF6 complex. Transl Res. 2016 Sep;175:129-143.e13. doi: 10.1016/j.trsl.2016.04.001. Epub 2016 Apr 13.
14 Evaluation of the novel mitotic modulator ON 01910.Na in pancreatic cancer and preclinical development of an ex vivo predictive assay. Oncogene. 2009 Jan 29;28(4):610-8. doi: 10.1038/onc.2008.424. Epub 2008 Nov 24.
15 In vitro antitumor mechanism of (E)-N-(2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridin-3-yl)methanesulfonamide. Mol Pharmacol. 2015 Jan;87(1):18-30. doi: 10.1124/mol.114.093245. Epub 2014 Oct 14.
16 A fine-needle aspirate-based vulnerability assay identifies polo-like kinase 1 as a mediator of gemcitabine resistance in pancreatic cancer. Mol Cancer Ther. 2010 Feb;9(2):311-8. doi: 10.1158/1535-7163.MCT-09-0693. Epub 2010 Jan 26.
17 Treatment of higher risk myelodysplastic syndrome patients unresponsive to hypomethylating agents with ON 01910.Na. Leuk Res. 2012 Jan;36(1):98-103. doi: 10.1016/j.leukres.2011.08.022. Epub 2011 Sep 14.
18 Ran GTPase-activating protein 1 is a therapeutic target in diffuse large B-cell lymphoma. PLoS One. 2013 Nov 6;8(11):e79863. doi: 10.1371/journal.pone.0079863. eCollection 2013.
19 Efficacy of the polo-like kinase inhibitor rigosertib, alone or in combination with Abelson tyrosine kinase inhibitors, against break point cluster region-c-Abelson-positive leukemia cells. Oncotarget. 2015 Aug 21;6(24):20231-40. doi: 10.18632/oncotarget.4047.
20 The dual pathway inhibitor rigosertib is effective in direct patient tumor xenografts of head and neck squamous cell carcinomas. Mol Cancer Ther. 2013 Oct;12(10):1994-2005. doi: 10.1158/1535-7163.MCT-13-0206. Epub 2013 Jul 19.
21 Centmitor-1, a novel acridinyl-acetohydrazide, possesses similar molecular interaction field and antimitotic cellular phenotype as rigosertib, on 01910.Na. Mol Cancer Ther. 2014 May;13(5):1054-66. doi: 10.1158/1535-7163.MCT-13-0685. Epub 2014 Apr 18.
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