General Information of Drug (ID: DM3NUMH)

Drug Name
Aripiprazole Drug Info
Synonyms
129722-12-9; Abilify; Abilitat; Abilify Discmelt; OPC-14597; Discmelt; Opc 14597; OPC 31; OPC-31; 7-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butoxy]-3,4-dihydrocarbostyril; UNII-82VFR53I78; C23H27Cl2N3O2; HSDB 7320; 7-(4-(4-(2,3-DICHLOROPHENYL)PIPERAZIN-1-YL)BUTOXY)-3,4-DIHYDROQUINOLIN-2(1H)-ONE; CHEMBL1112; 7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}-1,2,3,4-tetrahydroquinolin-2-one; 7-(4-(4-(2,3-Dichlorophenyl)-1-piperazinyl)butyloxy)-3,4-dihydro-2(1H)-quinolinone; CHEBI:31236; Abilify; Aripiprazol; Aripiprazolum; Aripirazole; Arpizol; Asprito; Pripiprazole; Aripiprazole [USAN]; Otsuka brand of aripiprazole; OPC 14597; ALKS-9070; Abilify (TN); BMS-337039; Bristol-Myers Squibb brand of aripiprazole; Discmelt (TN); KS-1030; S06-0010; Aripiprazole (JAN/USAN/INN); 7-(4-(4-(2,3-Dichlorophenyl)-1-piperazinyl)butoxy)-3,4-dihydro-2(1H)-quinolinone; 7-(4-(4-(2,3-Dichlorophenyl)-1-piperazinyl)butoxy)-3,4-dihydrocarbostyril; 7-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy]-3,4-dihydro-1H-quinolin-2-one; 7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}-3,4-dihydroquinolin-2(1H)-one; ALKS9070/ALKS9072; Aripiprazole/escitalopram fixed-dose combination
Indication
Disease Entry ICD 11 Status REF
Bipolar I disorder Approved [1]
Erythropoietic porphyrias 5C58.12 Approved [2]
Schizoaffective disorder 6A21 Approved [1]
Schizophrenia 6A20 Approved [3]
Major depressive disorder 6A70.3 Phase 3 [4]
Bipolar disorder 6A60 Application submitted [5]
Autism Investigative [1]
Therapeutic Class
Antipsychotic Agents
Cross-matching ID
PubChem CID
60795
ChEBI ID
CHEBI:31236
CAS Number
CAS 129722-12-9
TTD Drug ID
DM3NUMH
VARIDT Drug ID
DR00766
INTEDE Drug ID
DR0136
ACDINA Drug ID
D00043

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Preclinical Drug(s)
Drug(s) Targeting Dopamine D2 receptor (D2R)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [13]
Haloperidol DM96SE0 Delirium Approved [14]
Perphenazine DMA4MRX Schizophrenia 6A20 Approved [15]
Perazine DM2AOTZ Psychotic disorder 6A20-6A25 Approved [16]
Domperidone DMBDPY0 Gastrointestinal disease DE2Z Approved [17]
Levodopa DMN3E57 Parkinson disease 8A00.0 Approved [18]
Quetiapine DM1N62C Anorexia nervosa cachexia 6B80 Approved [19]
Pimozide DMW83TP Schizophrenia 6A20 Approved [20]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [21]
Iloperidone DM6AUFY Schizophrenia 6A20 Approved [22]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [23]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [24]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [25]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [26]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [27]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [28]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [29]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [30]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [24]
Verapamil DMA7PEW Angina pectoris BA40 Approved [31]
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Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [32]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [33]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [34]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [27]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [31]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [35]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [36]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [37]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [38]
Propranolol DM79NTF Angina pectoris BA40 Approved [39]
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Drug(s) Metabolized By Cytochrome P450 3A5 (CYP3A5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [40]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [41]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [42]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [8]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [43]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [44]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [45]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [46]
Verapamil DMA7PEW Angina pectoris BA40 Approved [47]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [8]
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Drug(s) Metabolized By Cytochrome P450 3A7 (CYP3A7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [48]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [8]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [8]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [8]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [49]
Verapamil DMA7PEW Angina pectoris BA40 Approved [50]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [8]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [8]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [8]
Metronidazole DMTIVEN Abscess Approved [51]
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Drug(s) Affected By Toll-like receptor 5 (TLR5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [52]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [53]
Arsenic DMTL2Y1 N. A. N. A. Approved [54]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [55]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [56]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [57]
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Drug(s) Affected By Prolactin (PRL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [58]
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [59]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [60]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [61]
Methotrexate DM2TEOL Anterior urethra cancer Approved [62]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [63]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [64]
Fluoxetine DM3PD2C Bipolar depression Approved [65]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [66]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [67]
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Drug(s) Affected By Interferon beta (IFNB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [68]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [70]
Hydroxychloroquine DMSIVND Chronic renal failure GB61.Z Approved [71]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [72]
Mitotane DMU1GX0 Adrenocortical carcinoma 2D11.Z Approved [72]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [73]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [74]
PF-3758309 DM36PKZ Solid tumour/cancer 2A00-2F9Z Phase 1 [75]
acetaldehyde DMJFKG4 Discovery agent N.A. Investigative [76]
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Drug(s) Affected By Fibronectin (FN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [77]
Methotrexate DM2TEOL Anterior urethra cancer Approved [62]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [79]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [80]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [81]
Ethacrynic acid DM60QMR Edema MG29 Approved [82]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [83]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [84]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [85]
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Drug(s) Affected By G antigen 1 (GAGE1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [56]
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paroxetine DM5PVQE Anxiety disorder 6B00-6B0Z Approved [86]
Fluoxetine DM3PD2C Bipolar depression Approved [87]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [88]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [89]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [90]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [91]
Quercetin DM3NC4M Obesity 5B81 Approved [92]
Gabapentin DM6T924 Complex partial seizure 8A68.0 Approved [90]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [93]
Mepyramine DMB4SFH Allergic rhinitis CA08.0 Approved [94]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [95]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [96]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [97]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [98]
Drug Name Drug ID Indication ICD 11 Highest Status REF
Metoclopramide DMFA5MY Nausea MD90 Approved [99]
Quinidine DMLPICK N. A. N. A. Approved [100]
Verapamil DMA7PEW Angina pectoris BA40 Approved [101]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [102]
Clarithromycin DM4M1SG Acute maxillary sinusitis Approved [102]
Disopyramide DM5SYZP Long QT syndrome BC65.0 Approved [103]
Propranolol DM79NTF Angina pectoris BA40 Approved [104]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [105]
Dofetilide DMPN1TW Sinus rhythm disorder BC9Y Approved [106]
Flecainide DMSQDLE Tachyarrhythmias BC71 Approved [102]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [107]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [107]
Testosterone DM7HUNW Hot flushes GA30 Approved [108]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [108]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [109]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [110]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [70]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [107]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [96]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [111]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [112]
Panobinostat DM58WKG Chronic graft versus host disease Approved [113]
Testosterone enanthate DMB6871 N. A. N. A. Approved [114]
Tubocurarine DMBZIVP Anaesthesia 9A78.6 Approved [115]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [52]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [116]
Mecamylamine DMGQFYB Essential hypertension BA00 Approved [115]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [53]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [70]
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Drug(s) Affected By Synaptotagmin-17 (SYT17)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [117]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [118]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [95]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [119]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [120]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [121]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [113]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [122]
THAPSIGARGIN DMDMQIE N. A. N. A. Preclinical [123]
COUMESTROL DM40TBU Discovery agent N.A. Investigative [124]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [62]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [125]
Testosterone DM7HUNW Hot flushes GA30 Approved [126]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [127]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [118]
Menthol DMG2KW7 Back pain ME84.Z Approved [128]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [96]
Arsenic DMTL2Y1 N. A. N. A. Approved [129]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [130]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [131]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Gabapentin DM6T924 Complex partial seizure 8A68.0 Approved [132]
Fluphenazine DMIT8LX Psychotic disorder 6A20-6A25 Approved [133]
Paliperidone DM7NPJS Psychotic disorder 6A20-6A25 Approved [134]
Haloperidol DM96SE0 Delirium Approved [134]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [95]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [70]
Olanzapine DMPFN6Y Bipolar depression Approved [135]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [136]
Arsenic DMTL2Y1 N. A. N. A. Approved [137]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [55]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Dopamine D2 receptor (D2R) TTEX248 DRD2_HUMAN Agonist [6]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) Main DME DE4LYSA CP3A4_HUMAN Substrate [7]
Cytochrome P450 2D6 (CYP2D6) Main DME DECB0K3 CP2D6_HUMAN Substrate [7]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Substrate [8]
Cytochrome P450 3A7 (CYP3A7) DERD86B CP3A7_HUMAN Substrate [8]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
5-hydroxytryptamine receptor 2A (HTR2A) OTWXJX0M 5HT2A_HUMAN Drug Response [9]
Cancer/testis antigen 1 (CTAG1B) OTIQGW6U CTG1B_HUMAN Gene/Protein Processing [10]
Fasciculation and elongation protein zeta-1 (FEZ1) OTWCXPRE FEZ1_HUMAN Gene/Protein Processing [10]
Fibronectin (FN1) OTB5ZN4Q FINC_HUMAN Gene/Protein Processing [10]
G antigen 1 (GAGE1) OT53E50E GAGE1_HUMAN Gene/Protein Processing [10]
Interferon beta (IFNB1) OTYQGUB5 IFNB_HUMAN Gene/Protein Processing [10]
Interferon-stimulated gene 20 kDa protein (ISG20) OTCWRJJW ISG20_HUMAN Gene/Protein Processing [10]
Nucleotide-binding oligomerization domain-containing protein 2 (NOD2) OTPGYWKC NOD2_HUMAN Gene/Protein Processing [10]
Potassium voltage-gated channel subfamily H member 2 (KCNH2) OTZX881H KCNH2_HUMAN Gene/Protein Processing [11]
Prolactin (PRL) OTWFQGX7 PRL_HUMAN Gene/Protein Processing [12]

References

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40 Drug related genetic polymorphisms affecting adverse reactions to methotrexate, vinblastine, doxorubicin and cisplatin in patients with urothelial cancer. J Urol. 2008 Dec;180(6):2389-95.
41 Human prostate CYP3A5: identification of a unique 5'-untranslated sequence and characterization of purified recombinant protein. Biochem Biophys Res Commun. 1999 Jul 14;260(3):676-81.
42 Polymorphisms in cytochrome P4503A5 (CYP3A5) may be associated with race and tumor characteristics, but not metabolism and side effects of tamoxifen in breast cancer patients. Cancer Lett. 2005 Jan 10;217(1):61-72.
43 Induction of hepatic CYP2E1 by a subtoxic dose of acetaminophen in rats: increase in dichloromethane metabolism and carboxyhemoglobin elevation. Drug Metab Dispos. 2007 Oct;35(10):1754-8.
44 Urinary 6 beta-hydroxycortisol excretion in rheumatoid arthritis. Br J Rheumatol. 1997 Jan;36(1):54-8.
45 Clinical pharmacokinetics of imatinib. Clin Pharmacokinet. 2005;44(9):879-94.
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47 Differential mechanism-based inhibition of CYP3A4 and CYP3A5 by verapamil. Drug Metab Dispos. 2005 May;33(5):664-71.
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