Details of the Drug-Related molecule(s) Interaction Atlas

Puromycin Drug Info

puromycin; Stylomycin; Puromycinum; Puromycine; Puromicina; UNII-4A6ZS6Q2CL; P-638; Stillomycin; CL 13900; 3123L; 4A6ZS6Q2CL; 3'-(L-alpha-Amino-p-methoxyhydrocinnamamido)-3'-deoxy-N,N-dimethyladenosine; (S)-3'-((2-Amino-3-(4-methoxyphenyl)-1-oxopropyl)amino)-3'-deoxy-N,N-dimethyladenosine; GNF-PF-2016; Puromycinum [INN-Latin]; Puromycine [INN-French]; Puromicina [INN-Spanish]; 9-{3-deoxy-3-[(O-methyl-L-tyrosyl)amino]-beta-D-xylofuranosyl}-N,N-dimethyl-9H-purin-6-amine; Bacterenomycin

Cross-matching ID

PubChem CID

439530

ChEBI ID

CHEBI:17939

CAS Number

CAS 53-79-2

TTD Drug ID

DMDKLB5

VARIDT Drug ID

DR01525

General Information of Drug (ID: DMDKLB5)

Molecule-Related Drug Atlas

Molecule Type:

DTP

DOT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Preclinical Drug(s)

Investigative Drug(s)

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Drug(s) Transported By P-glycoprotein 1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[10]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[11]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[12]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[13]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[12]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[12]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[14]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[12]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[15]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[16]
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Drug(s) Transported By Breast cancer resistance protein (ABCG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[17]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[18]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[19]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[20]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[21]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[22]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[23]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[22]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[24]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[25]
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Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[26]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[27]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[28]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[29]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[30]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[31]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[32]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[33]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[34]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[32]
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Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[35]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[36]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[37]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[38]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[41]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[42]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[43]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[44]
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Drug(s) Affected By Nephrin (NPHS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[48]
Bezafibrate	DMZDCS0	Hypercholesterolaemia	5C80.0	Approved	[49]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[50]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[51]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[52]
PIRINIXIC ACID	DM82Y75	Pulmonary fibrosis	CB03.4	Preclinical	[49]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[53]
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Drug(s) Affected By Low-density lipoprotein receptor (LDLR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[54]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[55]
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[54]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[56]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[57]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[59]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[60]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[61]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[62]
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Drug(s) Affected By Interleukin-6 receptor subunit alpha (IL6R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[63]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[59]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[65]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[66]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[67]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[68]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[6]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[69]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[70]
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Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[71]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[72]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[73]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[74]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[75]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[76]
Selenium	DM25CGV	N. A.	N. A.	Approved	[77]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[78]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[79]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[80]
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Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[81]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[82]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[83]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[73]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[84]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[75]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[85]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[86]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[87]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[85]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[88]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[89]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[90]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[91]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[92]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[93]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[94]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[95]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[96]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[97]
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Drug(s) Affected By C-C motif chemokine 4 (CCL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[98]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[100]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[101]
Betamethasone	DMAHJEF	Acute adrenal insufficiency		Approved	[6]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[6]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[103]
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Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[104]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[105]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[106]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[107]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[108]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[109]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[78]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[110]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[111]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[112]
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Drug(s) Affected By Multidrug resistance-associated protein 1 (ABCC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[113]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[114]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[115]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[116]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[117]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[118]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[119]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[120]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[121]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[121]
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Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[122]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[123]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[124]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[125]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[126]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[127]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[128]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[129]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[130]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[131]
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Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[88]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[131]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[93]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[94]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[132]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[133]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[134]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[135]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[136]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[137]
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Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[138]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[139]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[140]
Selenium	DM25CGV	N. A.	N. A.	Approved	[141]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[142]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[80]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[143]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[144]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[145]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
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Drug(s) Affected By Differentially expressed in FDCP 6 homolog (DEF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[147]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[148]
Bortezomib	DMNO38U	Leukemia		Approved	[149]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[150]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[151]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[152]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[153]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[154]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Breast cancer resistance protein (ABCG2)	DTI7UX6	ABCG2_HUMAN	Substrate	[1]
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[2]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Protein Interaction/Cellular Processes	[3]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[4]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Regulation of Drug Effects	[5]
Bcl-2-like protein 1 (BCL2L1)	OTRC5K9O	B2CL1_HUMAN	Gene/Protein Processing	[4]
C-C motif chemokine 2 (CCL2)	OTAD2HEL	CCL2_HUMAN	Gene/Protein Processing	[6]
C-C motif chemokine 4 (CCL4)	OT6B8P25	CCL4_HUMAN	Gene/Protein Processing	[6]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Gene/Protein Processing	[4]
Cytochrome P450 1A1 (CYP1A1)	OTE4EFH8	CP1A1_HUMAN	Gene/Protein Processing	[7]
Differentially expressed in FDCP 6 homolog (DEF6)	OTIRBYVK	DEFI6_HUMAN	Protein Interaction/Cellular Processes	[8]
Heme oxygenase 1 (HMOX1)	OTC1W6UX	HMOX1_HUMAN	Gene/Protein Processing	[9]

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References

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2	ATP-binding cassette transporters as pitfalls in selection of transgenic cells. Anal Biochem. 2010 Apr 15;399(2):246-50.
3	Melatonin antagonizes the intrinsic pathway of apoptosis via mitochondrial targeting of Bcl-2. J Pineal Res. 2008 Apr;44(3):316-25. doi: 10.1111/j.1600-079X.2007.00532.x.
4	Melatonin promotes puromycin-induced apoptosis with activation of caspase-3 and 5'-adenosine monophosphate-activated kinase-alpha in human leukemia HL-60 cells. J Pineal Res. 2011 May;50(4):367-73. doi: 10.1111/j.1600-079X.2010.00852.x. Epub 2011 Jan 18.
5	ATP-binding cassette transporters as pitfalls in selection of transgenic cells. Anal Biochem. 2010 Apr 15;399(2):246-50. doi: 10.1016/j.ab.2009.12.014. Epub 2009 Dec 14.
6	Cell-based and cytokine-directed chemical screen to identify potential anti-multiple myeloma agents. Leuk Res. 2010 Jul;34(7):917-24. doi: 10.1016/j.leukres.2009.12.002. Epub 2010 Feb 8.
7	Superinduction of CYP1A1 in MCF10A cultures by cycloheximide, anisomycin, and puromycin: a process independent of effects on protein translation and unrelated to suppression of aryl hydrocarbon receptor proteolysis by the proteasome. Mol Pharmacol. 2004 Oct;66(4):936-47.
8	DEF6, a novel substrate for the Tec kinase ITK, contains a glutamine-rich aggregation-prone region and forms cytoplasmic granules that co-localize with P-bodies. J Biol Chem. 2012 Sep 7;287(37):31073-84. doi: 10.1074/jbc.M112.346767. Epub 2012 Jul 24.
9	A Quantitative Approach to Screen for Nephrotoxic Compounds In Vitro. J Am Soc Nephrol. 2016 Apr;27(4):1015-28. doi: 10.1681/ASN.2015010060. Epub 2015 Aug 10.
10	Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007.
11	MDR1 (ABCB1) G1199A (Ser400Asn) polymorphism alters transepithelial permeability and sensitivity to anticancer agents. Cancer Chemother Pharmacol. 2009 Jun;64(1):183-8.
12	Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64.
13	Folate transporter expression decreases in the human placenta throughout pregnancy and in pre-eclampsia. Pregnancy Hypertens. 2012 Apr;2(2):123-31.
14	Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein. Pharm Res. 2001 Dec;18(12):1660-8.
15	Antiestrogens and steroid hormones: substrates of the human P-glycoprotein. Biochem Pharmacol. 1994 Jul 19;48(2):287-92.
16	Association of genetic polymorphisms in the influx transporter SLCO1B3 and the efflux transporter ABCB1 with imatinib pharmacokinetics in patients with chronic myeloid leukemia. Ther Drug Monit. 2011 Apr;33(2):244-50.
17	Doxorubicin transport by RALBP1 and ABCG2 in lung and breast cancer. Int J Oncol. 2007 Mar;30(3):717-25.
18	Wild-type breast cancer resistance protein (BCRP/ABCG2) is a methotrexate polyglutamate transporter. Cancer Res. 2003 Sep 1;63(17):5538-43.
19	The effect of low pH on breast cancer resistance protein (ABCG2)-mediated transport of methotrexate, 7-hydroxymethotrexate, methotrexate diglutamate, folic acid, mitoxantrone, topotecan, and resveratrol in in vitro drug transport models. Mol Pharmacol. 2007 Jan;71(1):240-9.
20	Role of BCRP as a biomarker for predicting resistance to 5-fluorouracil in breast cancer. Cancer Chemother Pharmacol. 2009 May;63(6):1103-10.
21	Inhibiting the function of ABCB1 and ABCG2 by the EGFR tyrosine kinase inhibitor AG1478. Biochem Pharmacol. 2009 Mar 1;77(5):781-93.
22	Sterol transport by the human breast cancer resistance protein (ABCG2) expressed in Lactococcus lactis. J Biol Chem. 2003 Jun 6;278(23):20645-51.
23	The phytoestrogen genistein enhances multidrug resistance in breast cancer cell lines by translational regulation of ABC transporters. Cancer Lett. 2016 Jun 28;376(1):165-72.
24	Curcumin inhibits the activity of ABCG2/BCRP1, a multidrug resistance-linked ABC drug transporter in mice. Pharm Res. 2009 Feb;26(2):480-7.
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