Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMP6G8T)

• Drug Name: Topotecan Drug Info
• Synonyms: Hycamptamine; Hycamptin; Hycamtamine; Topotecane; Topotecanum; Topotecan lactone; SKF 104864; SKF-S 104864; TOPOTECAN, HYCAMTIN; Topotecan (BAN); Topotecan [INN:BAN]; Topotecane [INN-French]; Topotecanum [INN-Latin]; Topotecan Monohydrochloride, (S)-Isomer; (4S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; (S)-10-((Dimethylamino)methyl)-4-ethyl-4,9-dihydroxy-1H-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; (S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]-quinoline-3,14(4H,12H)-dione; (S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; 9-Dimethylaminomethyl-10-hydroxycamptothecin

Indication

Disease Entry	ICD 11	Status	REF
Central nervous system neoplasm		Approved	[1]
Cervical cancer	2C77.0	Approved	[1]
Epithelial ovarian cancer	2B5D	Approved	[1]
Lung cancer	2C25.0	Approved	[1]
Ovarian cancer	2C73	Approved	[2]
Solid tumour/cancer	2A00-2F9Z	Approved	[3]
Small-cell lung cancer	2C25.Y	Phase 1	[4]
Neuroblastoma	2D11.2	Investigative	[1]

• Therapeutic Class: Anticancer Agents
• Cross-matching ID:
  PubChem CID: 60700
  ChEBI ID: CHEMBL63632
  CAS Number: CAS 123948-87-8
  TTD Drug ID: DMP6G8T
  VARIDT Drug ID: DR00044
  ACDINA Drug ID: D00690

Molecule-Related Drug Atlas

Drug(s) Targeting DNA topoisomerase I (TOP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[5]
B-Lactams	DMR8YD6	Bacterial infection	1A00-1C4Z	Approved	[12]
Belotecan hydrocholoride	DM3SRJZ	Small-cell lung cancer	2C25.Y	Approved	[13]
Topetecan	DMAE6LK	Small-cell lung cancer	2C25.Y	Approved	[14]
Karenitecin	DMCRGY4	Lung cancer	2C25.0	Phase 3	[15]
Camptothecin	DM6CHNJ	Solid tumour/cancer	2A00-2F9Z	Phase 3	[16]
Exatecan	DMCA7FN	Solid tumour/cancer	2A00-2F9Z	Phase 3	[17]
Edotecarin	DM3ZL7D	Gastric adenocarcinoma	2B72	Phase 3	[18]
Rubitecan	DMDWU1S	Human immunodeficiency virus infection	1C62	Phase 3	[19]
Etirinotecan pegol	DMQHX1Y	Breast cancer	2C60-2C65	Phase 3	[20]

Drug(s) Transported By Multidrug resistance-associated protein 1 (ABCC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[21]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[22]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[23]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[25]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[7]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[26]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[27]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[28]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[29]

Drug(s) Transported By P-glycoprotein 1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[7]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[30]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[31]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[32]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[31]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[31]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[33]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[31]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[34]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[35]

Drug(s) Transported By Breast cancer resistance protein (ABCG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[36]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[38]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[39]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[40]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[41]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[42]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[41]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[43]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[44]

Drug(s) Transported By Multidrug and toxin extrusion protein 1 (SLC47A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aciclovir	DMYLOVR	Genital herpes	1A94	Approved	[8]
Metformin	DM89QE1	Colorectal carcinoma		Approved	[45]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[8]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[8]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[46]
Procainamide	DMNMXR8	Ventricular arrhythmias	BC71	Approved	[8]
Cephalexin	DMD5JU8	Acute otitis media	AB00	Approved	[47]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[48]
Dofetilide	DMPN1TW	Sinus rhythm disorder	BC9Y	Approved	[49]
Pyrimethamine	DM5X7VY	Malaria	1F40-1F45	Approved	[50]

Drug(s) Transported By Multidrug resistance-associated protein 4 (ABCC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[52]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[53]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[54]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[7]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[55]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[56]
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[57]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[58]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[7]

Drug(s) Transported By Multidrug and toxin extrusion protein 2 (SLC47A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aciclovir	DMYLOVR	Genital herpes	1A94	Approved	[8]
Metformin	DM89QE1	Colorectal carcinoma		Approved	[8]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[8]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[8]
Procainamide	DMNMXR8	Ventricular arrhythmias	BC71	Approved	[8]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[48]
Dofetilide	DMPN1TW	Sinus rhythm disorder	BC9Y	Approved	[49]
Estrone sulfate	DMVBIZL	Atrophic vaginitis	GA30.2	Approved	[8]
N-methylpyridinium	DMVUKEW	N. A.	N. A.	Preclinical	[8]
[14C]TEA	DM6SFYH	Discovery agent	N.A.	Investigative	[8]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[59]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[60]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[61]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[62]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[63]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[64]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[65]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[66]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[67]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[65]

Drug(s) Affected By Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[68]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[68]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[69]
Sunitinib	DMCBJSR	Acute undifferentiated leukemia		Approved	[70]
Rosuvastatin	DMMIQ7G	Arteriosclerosis	BD40	Approved	[71]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[72]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[73]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[75]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[76]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[77]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[78]
Fructose	DM43AN2	Vomiting	MD90	Approved	[70]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[79]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[80]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[81]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[82]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[83]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[84]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[85]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[86]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[87]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[88]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[89]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[90]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[91]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[90]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[92]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[93]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[94]

Drug(s) Affected By Histone H2AX (H2AX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[95]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Selenium	DM25CGV	N. A.	N. A.	Approved	[97]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[98]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[99]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[100]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[101]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[102]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[103]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[104]

Drug(s) Affected By Methylated-DNA--protein-cysteine methyltransferase (MGMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[105]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[106]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[107]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[109]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[111]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[112]
Dacarbazine	DMNPZL4	Adenocarcinoma	2D40	Approved	[113]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[114]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[115]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[116]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[89]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[117]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[118]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[119]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[120]
Fructose	DM43AN2	Vomiting	MD90	Approved	[121]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[122]

Drug(s) Affected By Catenin beta-1 (CTNNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[79]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[123]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[124]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[119]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[125]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[126]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[127]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[128]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[129]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[130]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[131]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[132]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[82]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[133]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[134]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[116]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[135]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[136]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[91]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[137]

Drug(s) Affected By Tumor protein 63 (TP63)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[138]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[139]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[141]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[142]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[143]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[144]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[146]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[147]

Drug(s) Affected By Bcl-2-like protein 12 (BCL2L12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[148]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[149]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[149]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[150]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[152]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[153]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[154]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[155]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[154]

Drug(s) Affected By Three-prime repair exonuclease 1 (TREX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[97]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[149]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[149]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[156]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[157]
Fotemustine	DMV62ED	Solid tumour/cancer	2A00-2F9Z	Approved	[158]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[158]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[97]

Drug(s) Affected By Histone H2A.V (H2AZ2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[159]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[160]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[161]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[162]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[163]
Rigosertib	DMOSTXF	Myelodysplastic syndrome	2A37	Phase 3	[164]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[165]

Drug(s) Affected By Receptor-interacting serine/threonine-protein kinase 2 (RIPK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[166]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[167]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[168]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[169]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[166]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[170]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[152]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[171]

Drug(s) Affected By 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial (BCKDHA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[172]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[163]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[174]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[175]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[176]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[163]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[177]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[178]

Drug(s) Affected By Secreted frizzled-related protein 1 (SFRP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[179]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[181]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[182]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[183]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[184]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[185]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[152]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[186]

Drug(s) Affected By Tripartite motif-containing protein 2 (TRIM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[138]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[187]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[188]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[170]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[150]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[174]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[187]

Drug(s) Affected By Tetraspanin-8 (TSPAN8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[167]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[169]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[190]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[191]
ACYLINE	DM9GRTK	Prostate cancer	2C82.0	Phase 2	[192]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[193]

Drug(s) Affected By Tumor necrosis factor alpha-induced protein 8 (TNFAIP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[194]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[167]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[195]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[196]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[170]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[197]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[159]

Drug(s) Affected By Optineurin (OPTN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[97]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[172]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[198]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[149]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[149]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[159]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[199]

Drug(s) Affected By Protein FAM171A1 (FAM171A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[167]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[150]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[174]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[200]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[201]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[155]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[190]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[11]

Drug(s) Affected By Filamin-C (FLNC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[138]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[202]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[202]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[142]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[174]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[202]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[203]

Drug(s) Affected By Cleavage stimulation factor subunit 2 tau variant (CSTF2T)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[150]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[159]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[204]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[174]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[190]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[205]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[206]

Drug(s) Affected By Fatty acid CoA ligase Acsl3 (ACSL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[207]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[208]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[209]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[149]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[210]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[211]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[212]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 (PIN4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[132]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[213]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[174]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[155]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[175]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[214]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[215]

Drug(s) Affected By C-Jun-amino-terminal kinase-interacting protein 4 (SPAG9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[216]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[217]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[159]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[146]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[190]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[218]

Drug(s) Affected By Sorcin (SRI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[220]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[159]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[174]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[221]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[222]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[187]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[155]

Drug(s) Affected By High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (PDE8A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[97]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[223]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[209]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[197]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[197]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[150]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[197]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[197]

Drug(s) Affected By Argininosuccinate synthase (ASS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[97]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[167]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[168]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[224]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[181]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[225]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[209]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[224]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[217]

Drug(s) Affected By Polyphosphoinositide phosphatase (FIG4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[97]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[167]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[146]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[155]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[205]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[163]

Drug(s) Affected By Ubiquitin-like protein ISG15 (ISG15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[166]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[167]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[226]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[166]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[202]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[227]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[183]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[217]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[228]

Drug(s) Affected By Leukocyte elastase inhibitor (SERPINB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[187]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[229]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[230]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[231]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[167]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[219]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[232]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[233]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[234]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[150]

Drug(s) Affected By Collagen alpha-2(V) chain (COL5A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[208]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[181]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[183]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[235]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[217]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[236]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[237]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[238]

Drug(s) Affected By Transcription activator BRG1 (SMARCA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[239]
Selenium	DM25CGV	N. A.	N. A.	Approved	[97]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[172]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[195]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[240]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[241]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[195]

Drug(s) Affected By Metal cation symporter ZIP8 (SLC39A8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[169]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[208]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[181]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[242]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[241]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[159]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[243]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[244]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[205]

Drug(s) Affected By Regulator of G-protein signaling 20 (RGS20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[138]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[167]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[169]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[167]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[245]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[174]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[246]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[246]

Drug(s) Affected By BTB/POZ domain-containing protein KCTD3 (KCTD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[161]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[175]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[205]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[247]
Fenretinide	DMRD5SP	Macular degeneration	9B78.3	Phase 3	[248]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[167]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[172]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[172]

Drug(s) Affected By Melanoma-associated antigen D1 (MAGED1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[167]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[237]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[161]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[146]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[187]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[175]

Drug(s) Affected By Ferritin heavy chain (FTH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[249]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[250]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[251]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[252]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[168]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[253]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[254]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[255]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[197]

Drug(s) Affected By Protein-glutamine gamma-glutamyltransferase 2 (TGM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[115]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[256]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[257]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[149]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[149]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[258]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[259]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[260]

Drug(s) Affected By G-protein-signaling modulator 2 (GPSM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[261]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[262]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[167]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[149]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[149]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[217]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[263]
Promegestone	DMK4S8I	Gynecological disease	GA6Z	Approved	[264]

Drug(s) Affected By Cytochrome b5 (CYB5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[187]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[167]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[208]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[159]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[265]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[174]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[237]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]

Drug(s) Affected By Ankycorbin (RAI14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[167]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[169]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[149]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[149]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[241]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[163]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[243]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[237]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[201]

Drug(s) Affected By Plasminogen activator inhibitor 2 (SERPINB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[86]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[266]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[167]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[267]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[267]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[268]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[269]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[270]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[170]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[159]

Drug(s) Affected By Replication protein A 70 kDa DNA-binding subunit (RPA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[271]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[272]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[123]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[168]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[273]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[150]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[274]

Drug(s) Affected By Signal transducer CD24 (CD24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[275]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[252]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[276]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[181]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[277]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[149]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[149]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[181]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[174]

Drug(s) Affected By Polypeptide N-acetylgalactosaminyltransferase 3 (GALNT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[167]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[181]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[240]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[155]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[278]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[163]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[11]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[181]

Drug(s) Affected By Forkhead box protein D1 (FOXD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[86]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[279]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[208]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[235]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[174]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[280]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[146]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[281]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[163]

Drug(s) Affected By Cbp/p300-interacting transactivator 2 (CITED2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[282]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[187]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[167]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[181]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[283]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[209]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[284]

Drug(s) Affected By Raftlin (RFTN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[83]
Selenium	DM25CGV	N. A.	N. A.	Approved	[97]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[252]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[169]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[183]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[245]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[174]

Drug(s) Affected By Mesoderm-specific transcript homolog protein (MEST)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[159]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[285]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[237]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[146]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[286]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[175]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[205]

Drug(s) Affected By Four-jointed box protein 1 (FJX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[187]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[181]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[235]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[243]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[146]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[190]

Drug(s) Affected By Calmodulin-regulated spectrin-associated protein 2 (CAMSAP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[287]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[169]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[217]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[163]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[221]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[155]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[218]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[288]

Drug(s) Affected By High mobility group nucleosome-binding domain-containing protein 3 (HMGN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[167]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[161]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[286]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[175]

Drug(s) Affected By Diphosphoinositol polyphosphate phosphohydrolase NUDT4B (NUDT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[169]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[208]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[181]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[235]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[221]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[278]

Drug(s) Affected By SEC14-like protein 1 (SEC14L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[149]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[170]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[217]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[200]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[289]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[205]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[290]

Drug(s) Affected By Autism susceptibility gene 2 protein (AUTS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[138]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[291]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[174]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[146]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[187]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[292]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[293]

Drug(s) Affected By Grancalcin (GCA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[252]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[167]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[219]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[150]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[161]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[218]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[294]

Drug(s) Affected By RNA polymerase II elongation factor ELL3 (ELL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[150]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[181]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[146]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[155]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[163]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[11]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[181]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[172]

Drug(s) Affected By Receptor-type tyrosine-protein phosphatase kappa (PTPRK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[167]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[295]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[150]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[159]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[186]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[174]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[221]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[222]

Drug(s) Affected By snRNA-activating protein complex subunit 1 (SNAPC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[287]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[149]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[149]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[217]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[284]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[146]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1C (CDKN1C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[187]
Selenium	DM25CGV	N. A.	N. A.	Approved	[97]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[296]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[297]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[267]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[267]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[183]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[235]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[298]

Drug(s) Affected By Stearoyl-CoA desaturase (SCD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[299]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[300]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[300]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[194]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[167]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[279]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[300]
Fructose	DM43AN2	Vomiting	MD90	Approved	[301]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[219]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[300]

Drug(s) Affected By Desmoplakin (DSP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[302]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[303]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[142]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[304]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[305]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[205]

Drug(s) Affected By Protein lin-7 homolog C (LIN7C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[187]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[240]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[306]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[307]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[205]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[288]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[293]

Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein D-like (HNRNPDL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[287]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[179]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[308]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[269]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[309]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[159]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[245]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[310]

Drug(s) Affected By Microtubule-associated tumor suppressor 1 (MTUS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[167]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[183]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[170]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[217]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[218]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[146]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[190]

Drug(s) Affected By Cilium assembly protein DZIP1 (DZIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[138]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[106]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[183]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[150]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[161]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[155]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[11]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[214]

Drug(s) Affected By Thiamin pyrophosphokinase 1 (TPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[284]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[174]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[146]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[155]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[281]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[205]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[311]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[290]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[281]

Drug(s) Affected By Cytoskeleton-associated protein 2 (CKAP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[287]
Selenium	DM25CGV	N. A.	N. A.	Approved	[97]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[149]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[149]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[217]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[159]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[161]

Drug(s) Affected By Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[274]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[138]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[187]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[300]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[300]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[312]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[300]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[313]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[314]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[219]

Drug(s) Affected By Tetraspanin-13 (TSPAN13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[235]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[159]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[174]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[155]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[203]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[205]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[294]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[163]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[315]

Drug(s) Affected By Tropomyosin alpha-1 chain (TPM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[287]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[229]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[167]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[209]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[150]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[304]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[316]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[237]
Bortezomib	DMNO38U	Leukemia		Approved	[298]

Drug(s) Affected By AP-5 complex subunit mu-1 (AP5M1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[167]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[150]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[159]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[174]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[190]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[317]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[181]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[318]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[316]

Drug(s) Affected By Protein eva-1 homolog B (EVA1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[167]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[149]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[149]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[319]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[175]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[281]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[205]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[206]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[320]

Drug(s) Affected By Gamma-adducin (ADD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[83]
Selenium	DM25CGV	N. A.	N. A.	Approved	[97]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[167]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[321]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[237]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[322]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]

Drug(s) Affected By Ras-related protein Rab-7L1 (RAB29)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[207]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[303]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[245]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[174]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[190]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[205]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[218]

Drug(s) Affected By H(+)/Cl(-) exchange transporter 3 (CLCN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[83]
Selenium	DM25CGV	N. A.	N. A.	Approved	[97]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[167]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[208]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[217]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[174]

Drug(s) Affected By Secernin-1 (SCRN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[187]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[235]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[323]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[246]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[278]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[324]

Drug(s) Affected By NGFI-A-binding protein 1 (NAB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[187]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[303]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[143]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[245]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[243]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[174]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[187]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[286]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[157]

Drug(s) Affected By Solute carrier family 35 member G2 (SLC35G2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[187]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[167]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[159]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[163]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[181]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[214]

Drug(s) Affected By Cadherin-1 (CDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[115]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[325]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[326]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[327]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[328]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[167]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[329]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[169]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[330]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[181]

Drug(s) Affected By Multiple C2 and transmembrane domain-containing protein 2 (MCTP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flucloxacillin	DMNUWST	Bacterial infection	1A00-1C4Z	Approved	[331]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[252]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[169]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[183]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[209]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[143]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[218]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[315]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[214]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[172]

Drug(s) Affected By Caveolae-associated protein 1 (CAVIN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[332]
Selenium	DM25CGV	N. A.	N. A.	Approved	[97]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[208]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[149]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[149]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[150]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[217]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[213]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[265]

Drug(s) Affected By Laminin subunit alpha-2 (LAMA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[267]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[267]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[181]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[142]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[159]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[186]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[267]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[333]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[205]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[315]

Drug(s) Affected By Centriolar satellite-associated tubulin polyglutamylase complex regulator 1 (CSTPP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[159]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[205]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[206]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[108]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[138]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[245]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 2 (BIRC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[334]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[335]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[336]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[337]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[338]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[339]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[340]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[341]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[342]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[343]

Drug(s) Affected By Transmembrane protein 80 (TMEM80)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[187]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[150]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[146]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[155]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[205]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[344]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[288]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[345]

Drug(s) Affected By Cytotoxic granule associated RNA binding protein TIA1 (TIA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[287]
Selenium	DM25CGV	N. A.	N. A.	Approved	[97]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[167]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[346]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[150]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[159]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[174]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[190]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[157]

Drug(s) Affected By Epithelial cell adhesion molecule (EPCAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[347]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[181]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[270]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[235]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[174]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[348]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[349]

Drug(s) Affected By DNA damage-inducible transcript 4 protein (DDIT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[350]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[261]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[137]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[351]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[167]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[352]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[195]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[223]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[353]

Drug(s) Affected By Interstitial collagenase (MMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[271]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[354]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[355]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[356]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[231]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[357]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[358]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[359]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[360]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[232]

Drug(s) Affected By Solute carrier family 38 member 6 (SLC38A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[167]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[75]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[361]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[209]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[217]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[174]
Bortezomib	DMNO38U	Leukemia		Approved	[298]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[146]

Drug(s) Affected By G2/mitotic-specific cyclin-B2 (CCNB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[271]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[362]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[187]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[262]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[167]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[168]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[363]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[364]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[196]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[149]

Drug(s) Affected By Laminin subunit gamma-1 (LAMC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[219]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[208]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[365]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[235]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[213]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[174]
Indomethacin	DMSC4A7	Bursitis		Approved	[366]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[187]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[286]

Drug(s) Affected By Cyclin-G2 (CCNG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[367]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[167]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[122]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[181]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[367]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[240]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[170]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[197]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[197]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[150]

Drug(s) Affected By Beta/gamma crystallin domain-containing protein 1 (CRYBG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[187]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[167]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[181]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[150]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[213]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[368]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[161]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[146]

Drug(s) Affected By Ras-related protein Rab-13 (RAB13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[240]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[369]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[369]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[294]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[288]
SB-431542	DM0YOXQ	Pulmonary fibrosis	CB03.4	Preclinical	[370]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[345]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[316]

Drug(s) Affected By Ankyrin repeat domain-containing protein 10 (ANKRD10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[167]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[150]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[245]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[186]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[298]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[174]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[202]

Drug(s) Affected By Histone deacetylase complex subunit SAP18 (SAP18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[138]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[167]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[150]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[371]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[206]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[165]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[214]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[288]
QUERCITRIN	DM1DH96	Discovery agent	N.A.	Investigative	[372]

Drug(s) Affected By E3 ubiquitin-protein ligase FANCL (FANCL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[167]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[168]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[213]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[200]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[373]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[286]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[190]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[205]

Drug(s) Affected By Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HADH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[208]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[303]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[209]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[159]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[374]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[375]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[174]

Drug(s) Affected By FERM domain-containing protein 4A (FRMD4A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[187]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[174]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[376]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[144]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[201]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[187]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[377]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[190]

Drug(s) Affected By Cyclin-F (CCNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[86]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[297]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[168]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[219]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[364]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[378]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[353]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[149]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[149]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]

Drug(s) Affected By Jupiter microtubule associated homolog 2 (JPT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[252]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[150]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[181]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[155]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[205]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[163]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[288]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[379]
QUERCITRIN	DM1DH96	Discovery agent	N.A.	Investigative	[372]

Drug(s) Affected By TBC1 domain family member 4 (TBC1D4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[187]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[169]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[150]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[159]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[245]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[243]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[174]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[369]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[290]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6B (TNFRSF6B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[223]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[152]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[146]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[214]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[380]

Drug(s) Affected By Myelin protein zero-like protein 2 (MPZL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[159]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[243]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[348]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[246]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[246]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[175]

Drug(s) Affected By Transmembrane channel-like protein 6 (TMC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[252]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[219]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[183]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[149]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[170]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[150]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[381]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[319]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[161]

Drug(s) Affected By Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 (PLOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[97]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[167]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[382]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[181]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[383]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[167]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[217]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[159]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[383]

Drug(s) Affected By Enolase-phosphatase E1 (ENOPH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[159]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[384]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[288]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[172]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[385]

Drug(s) Affected By Calcium-binding tyrosine phosphorylation-regulated protein (CABYR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[132]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[187]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[169]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[235]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[146]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[386]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[387]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[11]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[214]

Drug(s) Affected By Glycylpeptide N-tetradecanoyltransferase 2 (NMT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[167]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[240]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[286]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[155]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[11]

Drug(s) Affected By Hemicentin-1 (HMCN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[170]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[284]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[388]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[243]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[389]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[237]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[278]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[390]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[315]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[391]

Drug(s) Affected By Ribosome biogenesis protein BOP1 (BOP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[172]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[169]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[240]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[174]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[157]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[205]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[392]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[172]

Drug(s) Affected By Eukaryotic peptide chain release factor GTP-binding subunit ERF3B (GSPT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[393]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[159]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[174]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[190]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[214]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[394]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[395]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[181]

Drug(s) Affected By Four and a half LIM domains protein 1 (FHL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[396]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[397]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[298]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[389]
Isoproterenol	DMK7MEY	Atrioventricular block		Approved	[398]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[174]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[399]

Drug(s) Affected By MAP kinase-interacting serine/threonine-protein kinase 2 (MKNK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[167]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[150]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[245]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[319]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[237]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[373]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[246]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[246]

Drug(s) Affected By Epithelial splicing regulatory protein 1 (ESRP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[400]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[181]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[361]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[142]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[159]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[187]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[163]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[11]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[181]

Drug(s) Affected By Radixin (RDX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Haloperidol	DM96SE0	Delirium		Approved	[274]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[369]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[306]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[78]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[176]
Isoflavone	DM7U58J	N. A.	N. A.	Phase 4	[401]

Drug(s) Affected By Calcium-activated potassium channel subunit alpha-1 (KCNMA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[138]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[252]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[169]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[240]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[174]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[156]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[201]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[155]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[402]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[390]

Drug(s) Affected By Paraneoplastic antigen-like protein 8A (PNMA8A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[235]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[246]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[246]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[205]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[206]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[384]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[316]

Drug(s) Affected By Polypeptide N-acetylgalactosaminyltransferase 1 (GALNT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[97]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[179]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[163]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[403]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[163]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[97]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[392]
Nicotinamide mononucleotide	DMW1LKP	N. A.	N. A.	Preclinical	[404]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[138]

Drug(s) Affected By BH3-interacting domain death agonist (BID)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[405]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[89]
Selenium	DM25CGV	N. A.	N. A.	Approved	[406]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[407]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[313]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[169]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[408]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[409]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[410]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]

Drug(s) Affected By Unconventional myosin-Id (MYO1D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[181]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[149]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[170]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[146]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[155]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[203]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[206]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[181]

Drug(s) Affected By Rho GTPase-activating protein 7 (DLC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[252]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[106]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[181]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[411]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[412]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[243]

Drug(s) Affected By Ras-related protein Rab-20 (RAB20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[252]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[167]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[181]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[245]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[260]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[280]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[190]

Drug(s) Affected By Dual specificity protein phosphatase 3 (DUSP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[150]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[174]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[413]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[246]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[246]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[187]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[414]

Drug(s) Affected By DNA dC->dU-editing enzyme APOBEC-3C (APOBEC3C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[303]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[209]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[150]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[217]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[163]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[245]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Artesunate	DMR27C8	Infection of P. falciparum	1F40	Approved	[415]

Drug(s) Affected By Pentraxin-related protein PTX3 (PTX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[416]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[169]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[417]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[159]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[245]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[389]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[200]
Bortezomib	DMNO38U	Leukemia		Approved	[418]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[146]

Drug(s) Affected By Dermatan-sulfate epimerase (DSE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[97]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[167]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[303]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[243]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[146]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[203]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[162]

Drug(s) Affected By Centromere protein U (CENPU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[167]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[149]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[149]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[163]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[245]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[319]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[389]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[174]

Drug(s) Affected By Sortilin-related receptor (SORL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[187]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[197]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[197]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[197]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[316]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[197]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[197]

Drug(s) Affected By Collagen alpha-2(VI) chain (COL6A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[138]
Selenium	DM25CGV	N. A.	N. A.	Approved	[97]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[208]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[217]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[265]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[319]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[174]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[348]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[237]

Drug(s) Affected By Ran-specific GTPase-activating protein (RANBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[252]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[168]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[169]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[270]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[419]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[419]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]

Drug(s) Affected By MAPK/MAK/MRK overlapping kinase (MOK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[337]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[170]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[201]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[371]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[205]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[11]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[11]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[11]

Drug(s) Affected By Keratin, type I cytoskeletal 23 (KRT23)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[167]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[420]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[183]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[142]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[235]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[160]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[238]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[421]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[187]

Drug(s) Affected By Transforming growth factor-beta-induced protein ig-h3 (TGFBI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[235]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[316]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[422]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[237]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[310]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[423]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[155]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[190]

Drug(s) Affected By Large ribosomal subunit protein mL63 (MRPL57)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[240]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[213]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[205]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[11]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[11]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[206]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[424]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[293]

Drug(s) Affected By Actin, gamma-enteric smooth muscle (ACTG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[308]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[308]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[149]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[149]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[150]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[159]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[243]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[389]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[174]

Drug(s) Affected By Acidic leucine-rich nuclear phosphoprotein 32 family member A (ANP32A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[83]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[425]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[160]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[306]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[286]

Drug(s) Affected By Calcium/calmodulin-dependent protein kinase type 1 (CAMK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[179]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[219]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[146]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[219]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[426]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[427]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[214]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[288]

Drug(s) Affected By Receptor tyrosine-protein kinase erbB-3 (ERBB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[282]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[428]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[167]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[181]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[142]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[284]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[429]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[430]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[431]

Drug(s) Affected By Arginine and glutamate-rich protein 1 (ARGLU1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[132]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[188]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[252]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[150]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[245]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[174]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[221]

Drug(s) Affected By Dr1-associated corepressor (DRAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[167]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[321]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[150]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[174]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[203]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[11]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[11]

Drug(s) Affected By Latent-transforming growth factor beta-binding protein 2 (LTBP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[170]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[235]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[160]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[237]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[155]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[205]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[163]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[11]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[11]

Drug(s) Affected By Heat shock-related 70 kDa protein 2 (HSPA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[86]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[187]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[425]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[168]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[432]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[302]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[254]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[270]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[159]

Drug(s) Affected By Lumican (LUM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[169]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[142]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[217]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[186]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[389]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[237]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[278]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[162]

Drug(s) Affected By GTP-binding protein SAR1a (SAR1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[302]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[159]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[286]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[344]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[433]
Nickel chloride	DMI12Y8	Discovery agent	N.A.	Investigative	[434]

Drug(s) Affected By Plasminogen activator inhibitor 1 (SERPINE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[435]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[436]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[437]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[438]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[439]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[440]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[313]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[441]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[442]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[443]

Drug(s) Affected By Collagen alpha-1(III) chain (COL3A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[444]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[445]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[446]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[447]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[448]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[269]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[449]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[142]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[450]

Drug(s) Affected By KH domain-containing RNA-binding protein QKI (QKI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[208]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[240]
Haloperidol	DM96SE0	Delirium		Approved	[451]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[155]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[452]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[205]

Drug(s) Affected By Cullin-4A (CUL4A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[287]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[226]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[150]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[245]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[243]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[174]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[310]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[187]

Drug(s) Affected By Homeobox protein Hox-B2 (HOXB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[284]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[160]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[174]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[453]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[315]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[454]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[455]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[288]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[456]

Drug(s) Affected By Collagen alpha-1(XV) chain (COL15A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[303]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[457]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[163]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[237]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[238]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[146]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[403]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[458]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[459]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[391]

Drug(s) Affected By A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[168]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[460]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[223]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[269]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[303]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[241]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[159]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[243]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[237]

Drug(s) Affected By Nuclear receptor-interacting protein 3 (NRIP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[181]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[240]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[159]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[160]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[243]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[174]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[306]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[292]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[162]

Drug(s) Affected By Granulocyte-macrophage colony-stimulating factor receptor subunit alpha (CSF2RA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[287]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[159]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[218]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[455]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[288]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[316]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[456]

Drug(s) Affected By La-related protein 6 (LARP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[187]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[167]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[168]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[169]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[159]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[461]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[319]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[237]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]

Drug(s) Affected By General transcription factor II-I (GTF2I)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[188]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[159]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[298]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[413]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[187]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[190]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[462]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[218]

Drug(s) Affected By Protein aurora borealis (BORA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[132]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[167]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[169]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[353]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[235]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[159]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[263]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[389]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[161]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[463]

Drug(s) Affected By FYVE, RhoGEF and PH domain-containing protein 1 (FGD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[319]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[218]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[214]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[288]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[172]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[172]

Drug(s) Affected By Matrilin-2 (MATN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[420]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[464]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[318]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[159]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[314]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[174]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[310]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[155]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[278]

Drug(s) Affected By Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (MACF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[138]
Selenium	DM25CGV	N. A.	N. A.	Approved	[97]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[169]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[308]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[241]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[217]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[146]

Drug(s) Affected By Serine protease FAM111A (FAM111A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[97]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[245]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[263]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[314]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[369]

Drug(s) Affected By Interleukin-1 receptor accessory protein-like 1 (IL1RAPL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[138]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[181]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[159]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[174]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[218]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[181]
PD-0325901	DM27D4J	Breast cancer	2C60-2C65	Phase 2	[465]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[454]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[214]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[288]

Drug(s) Affected By Tissue alpha-L-fucosidase (FUCA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[219]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[240]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[159]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[245]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[160]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[243]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[174]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]

Drug(s) Affected By Fanconi anemia group I protein (FANCI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[271]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[287]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[167]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[149]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[466]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[149]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[163]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[263]

Drug(s) Affected By U2 small nuclear ribonucleoprotein A' (SNRPA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[245]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[310]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[286]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[11]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[455]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[172]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[467]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[293]

Drug(s) Affected By Methyl-CpG-binding domain protein 4 (MBD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[468]
Selenium	DM25CGV	N. A.	N. A.	Approved	[97]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[167]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[240]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[217]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[245]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[174]

Drug(s) Affected By ORC ubiquitin ligase 1 (OBI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[187]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[174]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[146]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[155]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[205]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[165]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[172]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[395]

Drug(s) Affected By Condensin complex subunit 2 (NCAPH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[275]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[262]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[469]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[149]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[149]
Haloperidol	DM96SE0	Delirium		Approved	[274]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[258]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[159]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[245]

Drug(s) Affected By Collagen alpha-2(I) chain (COL1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[169]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[181]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[240]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[142]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[450]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[459]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[217]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[237]

Drug(s) Affected By Collagen alpha-1(VI) chain (COL6A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[267]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[267]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[181]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[217]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[265]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[348]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[267]

Drug(s) Affected By Protein FAN (NSMAF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[97]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[470]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[159]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[152]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[174]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[471]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[205]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[218]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[11]

Drug(s) Affected By Protein Niban 1 (NIBAN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[97]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[169]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[472]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[183]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[170]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[258]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[213]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[461]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[243]

Drug(s) Affected By Nucleolar complex protein 3 homolog (NOC3L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[287]
Selenium	DM25CGV	N. A.	N. A.	Approved	[97]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[169]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[157]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[206]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[97]

Drug(s) Affected By Acetyl-CoA acetyltransferase, cytosolic (ACAT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[167]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[169]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[208]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[469]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[213]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[473]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[243]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[399]

Drug(s) Affected By Thiosulfate sulfurtransferase (TST)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[167]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[169]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[208]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[163]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[174]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[237]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[187]

Drug(s) Affected By Tissue factor pathway inhibitor 2 (TFPI2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[167]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[169]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[181]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[303]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[209]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[159]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[243]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[174]

Drug(s) Affected By Insulin-induced gene 1 protein (INSIG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[261]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[207]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[314]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[308]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[474]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[208]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[308]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[475]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[149]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[197]

Drug(s) Affected By Suppressor of tumorigenicity 7 protein (ST7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[149]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[149]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[217]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[201]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[278]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[205]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[11]

Drug(s) Affected By Fermitin family homolog 2 (FERMT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[167]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[361]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[150]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[217]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[159]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[160]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[237]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
DNA topoisomerase I (TOP1)	TTGTQHC	TOP1_HUMAN	Modulator	[5]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Multidrug resistance-associated protein 4 (ABCC4)	DTCSGPB	MRP4_HUMAN	Substrate	[6]
Multidrug resistance-associated protein 1 (ABCC1)	DTSYQGK	MRP1_HUMAN	Substrate	[7]
Multidrug and toxin extrusion protein 2 (SLC47A2)	DT3TX4H	S47A2_HUMAN	Substrate	[8]
Multidrug and toxin extrusion protein 1 (SLC47A1)	DTZGT0P	S47A1_HUMAN	Substrate	[8]
Breast cancer resistance protein (ABCG2)	DTI7UX6	ABCG2_HUMAN	Substrate	[9]
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[10]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial (BCKDHA)	OT0LHOZB	ODBA_HUMAN	Drug Response	[11]
A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1)	OTTLJH8W	ATS1_HUMAN	Drug Response	[11]
Acetyl-CoA acetyltransferase, cytosolic (ACAT2)	OTZ092ZJ	THIC_HUMAN	Drug Response	[11]
Acidic leucine-rich nuclear phosphoprotein 32 family member A (ANP32A)	OTRHPFO2	AN32A_HUMAN	Drug Response	[11]
Actin, gamma-enteric smooth muscle (ACTG2)	OTRDWUO0	ACTH_HUMAN	Drug Response	[11]
Ankycorbin (RAI14)	OT6USGBK	RAI14_HUMAN	Drug Response	[11]
Ankyrin repeat domain-containing protein 10 (ANKRD10)	OTIZ2VK8	ANR10_HUMAN	Drug Response	[11]
AP-5 complex subunit mu-1 (AP5M1)	OTDLWEBL	AP5M1_HUMAN	Drug Response	[11]
Arginine and glutamate-rich protein 1 (ARGLU1)	OTRVRZ4Z	ARGL1_HUMAN	Drug Response	[11]
Argininosuccinate synthase (ASS1)	OT4ZMG0Q	ASSY_HUMAN	Drug Response	[11]

References

• [1] Topotecan FDA Label
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7101).
• [3] Plant-derived compounds in clinical trials. Drug Discov Today. 2008 Feb;13(3-4):161-71.
• [4] ClinicalTrials.gov (NCT00765973) Topotecan Liposomes Injection for Small Cell Lung Cancer (SCLC), Ovarian Cancer and Other Advanced Solid Tumors. U.S. National Institutes of Health.
• [5] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
• [6] Topotecan is a substrate for multidrug resistance associated protein 4. Curr Drug Metab. 2006 Jan;7(1):105-18.
• [7] Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007.
• [8] Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters. Biochem Pharmacol. 2007 Jul 15;74(2):359-71.
• [9] Differential inhibition of murine Bcrp1/Abcg2 and human BCRP/ABCG2 by the mycotoxin fumitremorgin C. Eur J Pharmacol. 2010 Oct 10;644(1-3):41-8.
• [10] Involvement of P-glycoprotein, multidrug resistance protein 2 and breast cancer resistance protein in the transport of belotecan and topotecan in Caco-2 and MDCKII cells. Pharm Res. 2008 Nov;25(11):2601-12.
• [11] Gene expression profiling of 30 cancer cell lines predicts resistance towards 11 anticancer drugs at clinically achieved concentrations. Int J Cancer. 2006 Apr 1;118(7):1699-712. doi: 10.1002/ijc.21570.
• [12] Luteolin, an emerging anti-cancer flavonoid, poisons eukaryotic DNA topoisomerase I. Biochem J. 2002 Sep 1;366(Pt 2):653-61.
• [13] Impact of natural products on developing new anti-cancer agents. Chem Rev. 2009 Jul;109(7):3012-43.
• [14] Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).
• [15] Characterization of protein kinase chk1 essential for the cell cycle checkpoint after exposure of human head and neck carcinoma A253 cells to a novel topoisomerase I inhibitor BNP1350. Mol Pharmacol.2000 Mar;57(3):453-9.
• [16] Topoisomerase I inhibitors: camptothecins and beyond. Nat Rev Cancer. 2006 Oct;6(10):789-802.
• [17] Phase I study of topoisomerase I inhibitor exatecan mesylate (DX-8951f) given as weekly 24-hour infusions three of every four weeks. Clin Cancer Res. 2001 Dec;7(12):3963-70.
• [18] Edotecarin: a novel topoisomerase I inhibitor. Clin Colorectal Cancer. 2005 May;5(1):27-36.
• [19] Rubitecan. Expert Opin Investig Drugs. 2006 Jan;15(1):71-9.
• [20] Nonclinical pharmacokinetics and activity of etirinotecan pegol (NKTR-102), a long-acting topoisomerase 1 inhibitor, in multiple cancer models. Cancer Chemother Pharmacol. 2014 Dec;74(6):1125-37.
• [21] The role of bioreductive activation of doxorubicin in cytotoxic activity against leukaemia HL60-sensitive cell line and its multidrug-resistant sublines. Br J Cancer. 2005 Jul 11;93(1):89-97.
• [22] Transport of methotrexate (MTX) and folates by multidrug resistance protein (MRP) 3 and MRP1: effect of polyglutamylation on MTX transport. Cancer Res. 2001 Oct 1;61(19):7225-32.
• [23] Folate concentration dependent transport activity of the Multidrug Resistance Protein 1 (ABCC1). Biochem Pharmacol. 2004 Apr 15;67(8):1541-8.
• [24] Hammerhead ribozyme against gamma-glutamylcysteine synthetase sensitizes human colonic cancer cells to cisplatin by down-regulating both the glutathione synthesis and the expression of multidrug resistance proteins. Cancer Gene Ther. 2001 Oct;8(10):803-14.
• [25] Multidrug resistance-associated protein-1 functional activity in Calu-3 cells. J Pharmacol Exp Ther. 2001 Sep;298(3):1199-205.
• [26] ATP-Dependent efflux of CPT-11 and SN-38 by the multidrug resistance protein (MRP) and its inhibition by PAK-104P. Mol Pharmacol. 1999 May;55(5):921-8.
• [27] Structural determinants of substrate specificity differences between human multidrug resistance protein (MRP) 1 (ABCC1) and MRP3 (ABCC3). Drug Metab Dispos. 2008 Dec;36(12):2571-81.
• [28] Evaluation of transport of common antiepileptic drugs by human multidrug resistance-associated proteins (MRP1, 2 and 5) that are overexpressed in pharmacoresistant epilepsy. Neuropharmacology. 2010 Jun;58(7):1019-32.
• [29] Vinblastine and sulfinpyrazone export by the multidrug resistance protein MRP2 is associated with glutathione export. Br J Cancer. 2000 Aug;83(3):375-83.
• [30] MDR1 (ABCB1) G1199A (Ser400Asn) polymorphism alters transepithelial permeability and sensitivity to anticancer agents. Cancer Chemother Pharmacol. 2009 Jun;64(1):183-8.
• [31] Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64.
• [32] Folate transporter expression decreases in the human placenta throughout pregnancy and in pre-eclampsia. Pregnancy Hypertens. 2012 Apr;2(2):123-31.
• [33] Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein. Pharm Res. 2001 Dec;18(12):1660-8.
• [34] Antiestrogens and steroid hormones: substrates of the human P-glycoprotein. Biochem Pharmacol. 1994 Jul 19;48(2):287-92.
• [35] Association of genetic polymorphisms in the influx transporter SLCO1B3 and the efflux transporter ABCB1 with imatinib pharmacokinetics in patients with chronic myeloid leukemia. Ther Drug Monit. 2011 Apr;33(2):244-50.
• [36] Doxorubicin transport by RALBP1 and ABCG2 in lung and breast cancer. Int J Oncol. 2007 Mar;30(3):717-25.
• [37] Wild-type breast cancer resistance protein (BCRP/ABCG2) is a methotrexate polyglutamate transporter. Cancer Res. 2003 Sep 1;63(17):5538-43.
• [38] The effect of low pH on breast cancer resistance protein (ABCG2)-mediated transport of methotrexate, 7-hydroxymethotrexate, methotrexate diglutamate, folic acid, mitoxantrone, topotecan, and resveratrol in in vitro drug transport models. Mol Pharmacol. 2007 Jan;71(1):240-9.
• [39] Role of BCRP as a biomarker for predicting resistance to 5-fluorouracil in breast cancer. Cancer Chemother Pharmacol. 2009 May;63(6):1103-10.
• [40] Inhibiting the function of ABCB1 and ABCG2 by the EGFR tyrosine kinase inhibitor AG1478. Biochem Pharmacol. 2009 Mar 1;77(5):781-93.
• [41] Sterol transport by the human breast cancer resistance protein (ABCG2) expressed in Lactococcus lactis. J Biol Chem. 2003 Jun 6;278(23):20645-51.
• [42] The phytoestrogen genistein enhances multidrug resistance in breast cancer cell lines by translational regulation of ABC transporters. Cancer Lett. 2016 Jun 28;376(1):165-72.
• [43] Curcumin inhibits the activity of ABCG2/BCRP1, a multidrug resistance-linked ABC drug transporter in mice. Pharm Res. 2009 Feb;26(2):480-7.
• [44] Imatinib mesylate (STI571) is a substrate for the breast cancer resistance protein (BCRP)/ABCG2 drug pump. Blood. 2004 Nov 1;104(9):2940-2.
• [45] Human multidrug and toxin extrusion 1 (MATE1/SLC47A1) transporter: functional characterization, interaction with OCT2 (SLC22A2), and single nucleotide polymorphisms. Am J Physiol Renal Physiol. 2010 Apr;298(4):F997-F1005.
• [46] Molecular mechanism of renal tubular secretion of the antimalarial drug chloroquine. Antimicrob Agents Chemother. 2011 Jul;55(7):3091-8.
• [47] Reduced renal clearance of a zwitterionic substrate cephalexin in MATE1-deficient mice. J Pharmacol Exp Ther. 2010 Aug;334(2):651-6.
• [48] Abemaciclib Inhibits Renal Tubular Secretion Without Changing Glomerular Filtration Rate. Clin Pharmacol Ther. 2019 May;105(5):1187-1195.
• [49] FDA Drug Development and Drug Interactions
• [50] Expression of Organic Anion Transporter 1 or 3 in Human Kidney Proximal Tubule Cells Reduces Cisplatin Sensitivity. Drug Metab Dispos. 2018 May;46(5):592-599.
• [51] Interaction of nonsteroidal anti-inflammatory drugs with multidrug resistance protein (MRP) 2/ABCC2- and MRP4/ABCC4-mediated methotrexate transport. J Pharmacol Exp Ther. 2007 Jan;320(1):229-35.
• [52] Analysis of methotrexate and folate transport by multidrug resistance protein 4 (ABCC4): MRP4 is a component of the methotrexate efflux system. Cancer Res. 2002 Jun 1;62(11):3144-50.
• [53] ATP-binding cassette C transporters in human pancreatic carcinoma cell lines. Upregulation in 5-fluorouracil-resistant cells. Pancreatology. 2009;9(1-2):136-44.
• [54] The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs. Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9244-9.
• [55] Steroid and bile acid conjugates are substrates of human multidrug-resistance protein (MRP) 4 (ATP-binding cassette C4). Biochem J. 2003 Apr 15;371(Pt 2):361-7.
• [56] P-glycoprotein, but not multidrug resistance protein 4, plays a role in the systemic clearance of irinotecan and SN-38 in mice. Drug Metab Lett. 2010 Dec;4(4):195-201.
• [57] Polymorphisms in multidrug resistance-associated protein gene 4 is associated with outcome in childhood acute lymphoblastic leukemia. Blood. 2009 Aug 13;114(7):1383-6.
• [58] Role of glutathione in the multidrug resistance protein 4 (MRP4/ABCC4)-mediated efflux of cAMP and resistance to purine analogues. Biochem J. 2002 Feb 1;361(Pt 3):497-503.
• [59] Characteristics of P388/VMDRC.04, a simple, sensitive model for studying P-glycoprotein antagonists. Cancer Res. 1994 Feb 1;54(3):730-7.
• [60] Michaelis-Menten kinetic analysis of drugs of abuse to estimate their affinity to human P-glycoprotein. Toxicol Lett. 2013 Feb 27;217(2):137-42. doi: 10.1016/j.toxlet.2012.12.012. Epub 2012 Dec 27.
• [61] Editor's Highlight: PlacentalDisposition and Effects of Crizotinib: An Ex Vivo Study in the Isolated Dual-Side Perfused Human Cotyledon. Toxicol Sci. 2017 Jun 1;157(2):500-509. doi: 10.1093/toxsci/kfx063.
• [62] Functional evaluation of polymorphisms in the human ABCB1 gene and the impact on clinical responses of antiepileptic drugs. Pharmacogenet Genomics. 2008 May;18(5):390-402. doi: 10.1097/FPC.0b013e3282f85e36.
• [63] Cepharanthine potently enhances the sensitivity of anticancer agents in K562 cells. Cancer Sci. 2005 Jun;96(6):372-6. doi: 10.1111/j.1349-7006.2005.00057.x.
• [64] Clinical pharmacokinetic monitoring of itraconazole is warranted in only a subset of patients. Ther Drug Monit. 2005 Jun;27(3):322-33. doi: 10.1097/01.ftd.0000150135.22645.ea.
• [65] Evaluation of antipsychotic drugs as inhibitors of multidrug resistance transporter P-glycoprotein. Psychopharmacology (Berl). 2006 Sep;187(4):415-23. doi: 10.1007/s00213-006-0437-9. Epub 2006 Jun 30.
• [66] Actions of the selective protein kinase C inhibitor PKC412 on B-chronic lymphocytic leukemia cells in vitro. Haematologica. 2002 Feb;87(2):167-76.
• [67] Characterization of the ATPase activity of the Mr 170,000 to 180,000 membrane glycoprotein (P-glycoprotein) associated with multidrug resistance in K562/ADM cells. Cancer Res. 1988 Sep 1;48(17):4926-32.
• [68] Localization of breast cancer resistance protein (Bcrp) in endocrine organs and inhibition of its transport activity by steroid hormones. Cell Tissue Res. 2012 Aug;349(2):551-63. doi: 10.1007/s00441-012-1417-5. Epub 2012 May 13.
• [69] Pharmacogenetics of ABCG2 and adverse reactions to gefitinib. J Natl Cancer Inst. 2006 Dec 6;98(23):1739-42.
• [70] ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
• [71] ABCG2 polymorphism is associated with the low-density lipoprotein cholesterol response to rosuvastatin. Clin Pharmacol Ther. 2010 May;87(5):558-62.
• [72] Ciprofloxacin mediates cancer stem cell phenotypes in lung cancer cells through caveolin-1-dependent mechanism. Chem Biol Interact. 2016 Apr 25;250:1-11.
• [73] Proteomic identification of differentially expressed proteins associated with the multiple drug resistance in methotrexate-resistant human breast cancer cells. Int J Oncol. 2014 Jul;45(1):448-58.
• [74] Activation of beta-catenin signalling by GSK-3 inhibition increases p-glycoprotein expression in brain endothelial cells. J Neurochem. 2008 Aug;106(4):1855-65. doi: 10.1111/j.1471-4159.2008.05537.x. Epub 2008 Jul 4.
• [75] Differential gene expression in human hepatocyte cell lines exposed to the antiretroviral agent zidovudine. Arch Toxicol. 2014 Mar;88(3):609-23. doi: 10.1007/s00204-013-1169-3. Epub 2013 Nov 30.
• [76] Chronic imatinib mesylate exposure leads to reduced intracellular drug accumulation by induction of the ABCG2 (BCRP) and ABCB1 (MDR1) drug transport pumps. Cancer Biol Ther. 2005 Jul;4(7):747-52.
• [77] High-dose mitoxantrone induces programmed cell death or apoptosis in human myeloid leukemia cells. Blood. 1993 Nov 15;82(10):3133-40.
• [78] Gene expression data from acetaminophen-induced toxicity in human hepatic in vitro systems and clinical liver samples. Data Brief. 2016 Mar 26;7:1052-1057. doi: 10.1016/j.dib.2016.03.069. eCollection 2016 Jun.
• [79] Inhibition of autophagic flux differently modulates cannabidiol-induced death in 2D and 3D glioblastoma cell cultures. Sci Rep. 2020 Feb 14;10(1):2687. doi: 10.1038/s41598-020-59468-4.
• [80] Nitrogen mustard prevents transport of Fra-1 into the nucleus to promote c-Fos- and FosB-dependent IL-8 induction in injured mouse epidermis. Toxicol Lett. 2020 Feb 1;319:256-263. doi: 10.1016/j.toxlet.2019.10.006. Epub 2019 Oct 19.
• [81] Sertraline induces endoplasmic reticulum stress in hepatic cells. Toxicology. 2014 Aug 1;322:78-88. doi: 10.1016/j.tox.2014.05.007. Epub 2014 May 24.
• [82] Gene expression profiles with activation of the estrogen receptor alpha-selective estrogen receptor modulator complex in breast cancer cells expressing wild-type estrogen receptor. Cancer Res. 2002 Aug 1;62(15):4419-26.
• [83] Oxidative stress modulates theophylline effects on steroid responsiveness. Biochem Biophys Res Commun. 2008 Dec 19;377(3):797-802.
• [84] Nocodazole-induced p53-dependent c-Jun N-terminal kinase activation reduces apoptosis in human colon carcinoma HCT116 cells. J Biol Chem. 2002 Nov 15;277(46):43648-58. doi: 10.1074/jbc.M203214200. Epub 2002 Sep 6.
• [85] [Regulation mechanism of autophagy-related protein LC3 by c-Jun in methotrexate resistant human choriocarcinoma JEG-3 cells]. Zhonghua Fu Chan Ke Za Zhi. 2014 Jul;49(7):531-5.
• [86] Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
• [87] Evidence of securin-mediated resistance to gefitinib-induced apoptosis in human cancer cells. Chem Biol Interact. 2013 Apr 25;203(2):412-22. doi: 10.1016/j.cbi.2013.03.011. Epub 2013 Mar 22.
• [88] Cigarette smoke and asbestos activate poly-ADP-ribose polymerase in alveolar epithelial cells. J Investig Med. 2001 Jan;49(1):68-76. doi: 10.2310/6650.2001.34092.
• [89] Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53. Cancer Res. 2004 May 1;64(9):3022-9. doi: 10.1158/0008-5472.can-03-1880.
• [90] The antidepressants imipramine, clomipramine, and citalopram induce apoptosis in human acute myeloid leukemia HL-60 cells via caspase-3 activation. J Biochem Mol Toxicol. 1999;13(6):338-47. doi: 10.1002/(sici)1099-0461(1999)13:6<338::aid-jbt8>3.0.co;2-7.
• [91] Ciprofloxacin mediated cell growth inhibition, S/G2-M cell cycle arrest, and apoptosis in a human transitional cell carcinoma of the bladder cell line. Clin Cancer Res. 2000 Mar;6(3):891-900.
• [92] Investigation of molecular mechanisms underlying the antiproliferative effects of colchicine against PC3 prostate cancer cells. Toxicol In Vitro. 2021 Jun;73:105138. doi: 10.1016/j.tiv.2021.105138. Epub 2021 Mar 6.
• [93] Sulindac enhances adenoviral vector expressing mda-7/IL-24-mediated apoptosis in human lung cancer. Mol Cancer Ther. 2005 Feb;4(2):291-304.
• [94] Methotrexate induces poly(ADP-ribose) polymerase-dependent, caspase 3-independent apoptosis in subsets of proliferating CD4+ T cells. Clin Exp Immunol. 2007 May;148(2):288-95. doi: 10.1111/j.1365-2249.2007.03335.x. Epub 2007 Feb 7.
• [95] Cannabinoids synergize with carfilzomib, reducing multiple myeloma cells viability and migration. Oncotarget. 2016 Nov 22;7(47):77543-77557. doi: 10.18632/oncotarget.12721.
• [96] Hsa-let-7g miRNA regulates the anti-tumor effects of gastric cancer cells under oxidative stress through the expression of DDR genes. J Toxicol Sci. 2015 Jun;40(3):329-38. doi: 10.2131/jts.40.329.
• [97] Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
• [98] Inhibition of cardiomyocyte differentiation of human induced pluripotent stem cells by Ribavirin: Implication for its cardiac developmental toxicity. Toxicology. 2020 Apr 15;435:152422. doi: 10.1016/j.tox.2020.152422. Epub 2020 Feb 26.
• [99] Synthesis and structure-activity relationships of new antiproliferative and proapoptotic retinoid-related biphenyl-4-yl-acrylic acids. Bioorg Med Chem. 2007 Jul 15;15(14):4863-75. doi: 10.1016/j.bmc.2007.04.057. Epub 2007 May 3.
• [100] Methotrexate induces apoptosis through p53/p21-dependent pathway and increases E-cadherin expression through downregulation of HDAC/EZH2. Biochem Pharmacol. 2011 Feb 15;81(4):510-7. doi: 10.1016/j.bcp.2010.11.014. Epub 2010 Nov 27.
• [101] Actinomycin D inhibits the expression of the cystine/glutamate transporter xCT via attenuation of CD133 synthesis in CD133(+) HCC. Chem Biol Interact. 2019 Aug 25;309:108713. doi: 10.1016/j.cbi.2019.06.026. Epub 2019 Jun 19.
• [102] Simvastatin and purine analogs have a synergic effect on apoptosis of chronic lymphocytic leukemia cells. Ann Hematol. 2010 Nov;89(11):1115-24. doi: 10.1007/s00277-010-0988-z. Epub 2010 May 25.
• [103] The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib. Toxicol Sci. 2023 Dec 21;197(1):69-78. doi: 10.1093/toxsci/kfad099.
• [104] The isoflavonoids genistein and quercetin activate different stress signaling pathways as shown by analysis of site-specific phosphorylation of ATM, p53 and histone H2AX. DNA Repair (Amst). 2004 Mar 4;3(3):235-44. doi: 10.1016/j.dnarep.2003.10.014.
• [105] Tumor necrosis factor-alpha-induced protein 3 as a putative regulator of nuclear factor-kappaB-mediated resistance to O6-alkylating agents in human glioblastomas. J Clin Oncol. 2006 Jan 10;24(2):274-87. doi: 10.1200/JCO.2005.02.9405. Epub 2005 Dec 19.
• [106] Comparative gene expression analysis of a chronic myelogenous leukemia cell line resistant to cyclophosphamide using oligonucleotide arrays and response to tyrosine kinase inhibitors. Leuk Res. 2007 Nov;31(11):1511-20.
• [107] Ouabain induces apoptotic cell death in human prostate DU 145 cancer cells through DNA damage and TRAIL pathways. Environ Toxicol. 2019 Dec;34(12):1329-1339. doi: 10.1002/tox.22834. Epub 2019 Aug 21.
• [108] Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
• [109] Disulfiram is a direct and potent inhibitor of human O6-methylguanine-DNA methyltransferase (MGMT) in brain tumor cells and mouse brain and markedly increases the alkylating DNA damage. Carcinogenesis. 2014 Mar;35(3):692-702. doi: 10.1093/carcin/bgt366. Epub 2013 Nov 5.
• [110] Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
• [111] Induction of the DNA repair gene O6-methylguanine-DNA methyltransferase by dexamethasone in glioblastomas. J Neurosurg. 2004 Oct;101(4):659-63. doi: 10.3171/jns.2004.101.4.0659.
• [112] Phenytoin may increase the efficacy of temozolomide by methylating DNA-repair enzyme, O6-methylguanine-DNA methyltransferase in patients with glioblastoma. Med Hypotheses. 2005;65(4):819-20. doi: 10.1016/j.mehy.2005.04.007.
• [113] Pharmacokinetic, biochemical and clinical effects of dimethyltriazenoimidazole-4-carboxamide-bischloroethylnitrosourea combination therapy in patients with advanced breast cancer. Int J Cancer. 2003 Feb 20;103(5):686-92. doi: 10.1002/ijc.10849.
• [114] Transcriptional repression of O6-methylguanine DNA methyltransferase gene rendering cells hypersensitive to N,N'-bis(2-chloroethyl)-N-nitrosurea in camptothecin-resistant cells. Mol Pharmacol. 2008 Aug;74(2):517-26. doi: 10.1124/mol.107.043620. Epub 2008 May 20.
• [115] Beta-carotene and apocarotenals promote retinoid signaling in BEAS-2B human bronchioepithelial cells. Arch Biochem Biophys. 2006 Nov 1;455(1):48-60.
• [116] Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells. Cancer Res. 2002 Nov 1;62(21):6246-54.
• [117] Topotecan and methotrexate alter expression of the apoptosis-related genes BCL2, FAS and BCL2L12 in leukemic HL-60 cells. Biol Chem. 2006 Dec;387(12):1629-33. doi: 10.1515/BC.2006.203.
• [118] Carvedilol prevents epinephrine-induced apoptosis in human coronary artery endothelial cells: modulation of Fas/Fas ligand and caspase-3 pathway. Cardiovasc Res. 2000 Feb;45(3):788-94. doi: 10.1016/s0008-6363(99)00369-7.
• [119] Multifaceted preventive effects of single agent quercetin on a human prostate adenocarcinoma cell line (PC-3): implications for nutritional transcriptomics and multi-target therapy. Med Oncol. 2011 Dec;28(4):1395-404. doi: 10.1007/s12032-010-9603-3. Epub 2010 Jul 2.
• [120] Regulatory role of KEAP1 and NRF2 in PPAR expression and chemoresistance in human non-small-cell lung carcinoma cells. Free Radic Biol Med. 2012 Aug 15;53(4):758-68. doi: 10.1016/j.freeradbiomed.2012.05.041. Epub 2012 Jun 7.
• [121] Non-nutritional sweeteners effects on endothelial vascular function. Toxicol In Vitro. 2020 Feb;62:104694. doi: 10.1016/j.tiv.2019.104694. Epub 2019 Oct 23.
• [122] Transcriptome-based functional classifiers for direct immunotoxicity. Arch Toxicol. 2014 Mar;88(3):673-89.
• [123] Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells. Free Radic Biol Med. 2002 Nov 15;33(10):1419-32.
• [124] Sulindac suppresses beta-catenin expression in human cancer cells. Eur J Pharmacol. 2008 Mar 31;583(1):26-31. doi: 10.1016/j.ejphar.2007.12.034. Epub 2008 Feb 5.
• [125] Multifaceted suppression of aggressive behavior of thyroid carcinoma by all-trans retinoic acid induced re-differentiation. Mol Cell Endocrinol. 2012 Jan 2;348(1):260-9. doi: 10.1016/j.mce.2011.09.002. Epub 2011 Sep 6.
• [126] Arsenic trioxide and 2-methoxyestradiol reduce beta-catenin accumulation after proteasome inhibition and enhance the sensitivity of myeloma cells to Bortezomib. Leuk Res. 2008 Nov;32(11):1674-83. doi: 10.1016/j.leukres.2008.03.039. Epub 2008 May 15.
• [127] Effect of aspirin on the Wnt/beta-catenin pathway is mediated via protein phosphatase 2A. Oncogene. 2006 Oct 19;25(49):6447-56. doi: 10.1038/sj.onc.1209658. Epub 2006 Jul 31.
• [128] Benzene metabolite hydroquinone induces apoptosis of bone marrow mononuclear cells through inhibition of -catenin signaling. Toxicol In Vitro. 2018 Feb;46:361-369. doi: 10.1016/j.tiv.2017.08.018. Epub 2017 Sep 5.
• [129] Anti-androgen 2-hydroxyflutamide modulates cadherin, catenin and androgen receptor phosphorylation in androgen-sensitive LNCaP and androgen-independent PC3 prostate cancer cell lines acting via PI3K/Akt and MAPK/ERK1/2 pathways. Toxicol In Vitro. 2017 Apr;40:324-335. doi: 10.1016/j.tiv.2017.01.019. Epub 2017 Feb 2.
• [130] Anthelmintic Niclosamide Disrupts the Interplay of p65 and FOXM1/-catenin and Eradicates Leukemia Stem Cells in Chronic Myelogenous Leukemia. Clin Cancer Res. 2017 Feb 1;23(3):789-803. doi: 10.1158/1078-0432.CCR-16-0226. Epub 2016 Aug 4.
• [131] Zidovudine induces S-phase arrest and cell cycle gene expression changes in human cells. Mutagenesis. 2005 Mar;20(2):139-46. doi: 10.1093/mutage/gei019. Epub 2005 Mar 22.
• [132] Cannabidiol Activates Neuronal Precursor Genes in Human Gingival Mesenchymal Stromal Cells. J Cell Biochem. 2017 Jun;118(6):1531-1546. doi: 10.1002/jcb.25815. Epub 2016 Dec 29.
• [133] Leptomycin B reduces primary and acquired resistance of gefitinib in lung cancer cells. Toxicol Appl Pharmacol. 2017 Nov 15;335:16-27. doi: 10.1016/j.taap.2017.09.017. Epub 2017 Sep 21.
• [134] BMN 673 (talazoparib): A potent PARP inhibitor for triple negative breast cancer with different genetic profile. J Biochem Mol Toxicol. 2019 May;33(5):e22286. doi: 10.1002/jbt.22286. Epub 2019 Jan 23.
• [135] Bexarotene activates the p53/p73 pathway in human cutaneous T-cell lymphoma. Br J Dermatol. 2009 Mar;160(3):519-26. doi: 10.1111/j.1365-2133.2008.08931.x. Epub 2008 Nov 25.
• [136] Glucocorticoids induce G1 arrest of lymphoblastic cells through retinoblastoma protein Rb1 dephosphorylation in childhood acute lymphoblastic leukemia in vivo. Cancer Biol Ther. 2004 May;3(5):470-6. doi: 10.4161/cbt.3.5.838. Epub 2004 May 9.
• [137] Utilization of CDKN1A/p21 gene for class discrimination of DNA damage-induced clastogenicity. Toxicology. 2014 Jan 6;315:8-16. doi: 10.1016/j.tox.2013.10.009. Epub 2013 Nov 6.
• [138] DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.
• [139] Flavones and flavonols exert cytotoxic effects on a human oesophageal adenocarcinoma cell line (OE33) by causing G2/M arrest and inducing apoptosis. Food Chem Toxicol. 2008 Jun;46(6):2042-53. doi: 10.1016/j.fct.2008.01.049. Epub 2008 Feb 7.
• [140] Activation of PPAR and inhibition of cell proliferation reduces key proteins associated with the basal subtype of bladder cancer in As3+-transformed UROtsa cells. PLoS One. 2020 Aug 21;15(8):e0237976. doi: 10.1371/journal.pone.0237976. eCollection 2020.
• [141] Induction of TAp63 by histone deacetylase inhibitors. Biochem Biophys Res Commun. 2010 Jan 22;391(4):1748-51. doi: 10.1016/j.bbrc.2009.12.147. Epub 2009 Dec 30.
• [142] Identification of vitamin D3 target genes in human breast cancer tissue. J Steroid Biochem Mol Biol. 2016 Nov;164:90-97.
• [143] Design principles of concentration-dependent transcriptome deviations in drug-exposed differentiating stem cells. Chem Res Toxicol. 2014 Mar 17;27(3):408-20.
• [144] Bone marrow osteoblast damage by chemotherapeutic agents. PLoS One. 2012;7(2):e30758. doi: 10.1371/journal.pone.0030758. Epub 2012 Feb 17.
• [145] Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
• [146] Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
• [147] Differential expression of microRNAs and their predicted targets in renal cells exposed to amphotericin B and its complex with copper (II) ions. Toxicol Mech Methods. 2017 Sep;27(7):537-543. doi: 10.1080/15376516.2017.1333554. Epub 2017 Jun 8.
• [148] Effect of doxorubicin, oxaliplatin, and methotrexate administration on the transcriptional activity of BCL-2 family gene members in stomach cancer cells. Cancer Biol Ther. 2013 Jul;14(7):587-96. doi: 10.4161/cbt.24591. Epub 2013 May 10.
• [149] Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
• [150] Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
• [151] Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
• [152] Repurposing L-menthol for systems medicine and cancer therapeutics? L-menthol induces apoptosis through caspase 10 and by suppressing HSP90. OMICS. 2016 Jan;20(1):53-64.
• [153] The effect of combination treatment with docosahexaenoic acid and 5-fluorouracil on the mRNA expression of apoptosis-related genes, including the novel gene BCL2L12, in gastric cancer cells. In Vitro Cell Dev Biol Anim. 2009 Jan-Feb;45(1-2):69-74. doi: 10.1007/s11626-008-9154-5. Epub 2008 Nov 18.
• [154] Breast cancer cells response to the antineoplastic agents cisplatin, carboplatin, and doxorubicin at the mRNA expression levels of distinct apoptosis-related genes, including the new member, BCL2L12. Ann N Y Acad Sci. 2007 Jan;1095:35-44. doi: 10.1196/annals.1397.005.
• [155] Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Toxicol Sci. 2015 Jan;143(1):97-106. doi: 10.1093/toxsci/kfu210. Epub 2014 Oct 10.
• [156] Identification by automated screening of a small molecule that selectively eliminates neural stem cells derived from hESCs but not dopamine neurons. PLoS One. 2009 Sep 23;4(9):e7155.
• [157] 17-Estradiol Activates HSF1 via MAPK Signaling in ER-Positive Breast Cancer Cells. Cancers (Basel). 2019 Oct 11;11(10):1533. doi: 10.3390/cancers11101533.
• [158] Human three prime exonuclease TREX1 is induced by genotoxic stress and involved in protection of glioma and melanoma cells to anticancer drugs. Biochim Biophys Acta. 2013 Aug;1833(8):1832-43. doi: 10.1016/j.bbamcr.2013.03.029. Epub 2013 Apr 8.
• [159] Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
• [160] Folic acid supplementation dysregulates gene expression in lymphoblastoid cells--implications in nutrition. Biochem Biophys Res Commun. 2011 Sep 9;412(4):688-92. doi: 10.1016/j.bbrc.2011.08.027. Epub 2011 Aug 16.
• [161] A transcriptomics-based in vitro assay for predicting chemical genotoxicity in vivo. Carcinogenesis. 2012 Jul;33(7):1421-9.
• [162] Identification of novel low-dose bisphenol a targets in human foreskin fibroblast cells derived from hypospadias patients. PLoS One. 2012;7(5):e36711. doi: 10.1371/journal.pone.0036711. Epub 2012 May 4.
• [163] Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay. Toxicol Sci. 2015 Aug;146(2):311-20. doi: 10.1093/toxsci/kfv094. Epub 2015 May 15.
• [164] ON 01910.Na is selectively cytotoxic for chronic lymphocytic leukemia cells through a dual mechanism of action involving PI3K/AKT inhibition and induction of oxidative stress. Clin Cancer Res. 2012 Apr 1;18(7):1979-91. doi: 10.1158/1078-0432.CCR-11-2113. Epub 2012 Feb 20.
• [165] Inhibiting ubiquitination causes an accumulation of SUMOylated newly synthesized nuclear proteins at PML bodies. J Biol Chem. 2019 Oct 18;294(42):15218-15234. doi: 10.1074/jbc.RA119.009147. Epub 2019 Jul 8.
• [166] Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration. Arthritis Res Ther. 2009;11(1):R15.
• [167] Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
• [168] Effects of ciglitazone and troglitazone on the proliferation of human stomach cancer cells. World J Gastroenterol. 2009 Jan 21;15(3):310-20.
• [169] Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
• [170] Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol. 2005 Nov;19(11):2685-95.
• [171] Triggering of transient receptor potential vanilloid type 1 (TRPV1) by capsaicin induces Fas/CD95-mediated apoptosis of urothelial cancer cells in an ATM-dependent manner. Carcinogenesis. 2009 Aug;30(8):1320-9. doi: 10.1093/carcin/bgp138. Epub 2009 Jun 5.
• [172] Quantitative phosphoproteomics reveal cellular responses from caffeine, coumarin and quercetin in treated HepG2 cells. Toxicol Appl Pharmacol. 2022 Aug 15;449:116110. doi: 10.1016/j.taap.2022.116110. Epub 2022 Jun 7.
• [173] Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
• [174] Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
• [175] Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
• [176] Multi-level gene expression profiles affected by thymidylate synthase and 5-fluorouracil in colon cancer. BMC Genomics. 2006 Apr 3;7:68. doi: 10.1186/1471-2164-7-68.
• [177] Quantitative proteomics and transcriptomics addressing the estrogen receptor subtype-mediated effects in T47D breast cancer cells exposed to the phytoestrogen genistein. Mol Cell Proteomics. 2011 Jan;10(1):M110.002170.
• [178] Identification of a transcriptomic signature of food-relevant genotoxins in human HepaRG hepatocarcinoma cells. Food Chem Toxicol. 2020 Jun;140:111297. doi: 10.1016/j.fct.2020.111297. Epub 2020 Mar 28.
• [179] Integrated assessment by multiple gene expression analysis of quercetin bioactivity on anticancer-related mechanisms in colon cancer cells in vitro. Eur J Nutr. 2005 Mar;44(3):143-56. doi: 10.1007/s00394-004-0503-1. Epub 2004 Apr 30.
• [180] Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
• [181] A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
• [182] Arsenic trioxide increases expression of secreted frizzled-related protein 1 gene and inhibits the WNT/-catenin signaling pathway in Jurkat cells. Exp Ther Med. 2017 May;13(5):2050-2055. doi: 10.3892/etm.2017.4184. Epub 2017 Mar 6.
• [183] Keratinocyte-derived IL-36gama plays a role in hydroquinone-induced chemical leukoderma through inhibition of melanogenesis in human epidermal melanocytes. Arch Toxicol. 2019 Aug;93(8):2307-2320.
• [184] Chronic ethanol exposure increases goosecoid (GSC) expression in human embryonic carcinoma cell differentiation. J Appl Toxicol. 2014 Jan;34(1):66-75.
• [185] Folic acid modulates cancer-associated micro RNAs and inflammatory mediators in neoplastic and non-neoplastic colonic cells in a different way. Mol Nutr Food Res. 2017 Dec;61(12). doi: 10.1002/mnfr.201700260. Epub 2017 Nov 9.
• [186] Mifepristone induced progesterone withdrawal reveals novel regulatory pathways in human endometrium. Mol Hum Reprod. 2007 Sep;13(9):641-54.
• [187] Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
• [188] Expression profile analysis of colon cancer cells in response to sulindac or aspirin. Biochem Biophys Res Commun. 2002 Mar 29;292(2):498-512.
• [189] Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
• [190] Gene expression analysis of precision-cut human liver slices indicates stable expression of ADME-Tox related genes. Toxicol Appl Pharmacol. 2011 May 15;253(1):57-69.
• [191] Gene expression profiling of human peri-implantation endometria between natural and stimulated cycles. Fertil Steril. 2008 Dec;90(6):2152-64.
• [192] Intraprostatic androgens and androgen-regulated gene expression persist after testosterone suppression: therapeutic implications for castration-resistant prostate cancer. Cancer Res. 2007 May 15;67(10):5033-41.
• [193] Novel ATP-competitive Akt inhibitor afuresertib suppresses the proliferation of malignant pleural mesothelioma cells. Cancer Med. 2017 Nov;6(11):2646-2659. doi: 10.1002/cam4.1179. Epub 2017 Sep 27.
• [194] The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
• [195] Motexafin gadolinium and zinc induce oxidative stress responses and apoptosis in B-cell lymphoma lines. Cancer Res. 2005 Dec 15;65(24):11676-88.
• [196] Classification of heavy-metal toxicity by human DNA microarray analysis. Environ Sci Technol. 2007 May 15;41(10):3769-74.
• [197] Transcriptomics hit the target: monitoring of ligand-activated and stress response pathways for chemical testing. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):7-18.
• [198] Retinoic acid receptor alpha amplifications and retinoic acid sensitivity in breast cancers. Clin Breast Cancer. 2013 Oct;13(5):401-8.
• [199] Capsaicin inhibits the migration, invasion and EMT of renal cancer cells by inducing AMPK/mTOR-mediated autophagy. Chem Biol Interact. 2022 Oct 1;366:110043. doi: 10.1016/j.cbi.2022.110043. Epub 2022 Aug 28.
• [200] CXCL14 downregulation in human keratinocytes is a potential biomarker for a novel in vitro skin sensitization test. Toxicol Appl Pharmacol. 2020 Jan 1;386:114828. doi: 10.1016/j.taap.2019.114828. Epub 2019 Nov 14.
• [201] The thioxotriazole copper(II) complex A0 induces endoplasmic reticulum stress and paraptotic death in human cancer cells. J Biol Chem. 2009 Sep 4;284(36):24306-19.
• [202] Genomic profiling uncovers a molecular pattern for toxicological characterization of mutagens and promutagens in vitro. Toxicol Sci. 2011 Jul;122(1):185-97.
• [203] Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: application to acetaminophen injury. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):270-80.
• [204] Targeting iron homeostasis induces cellular differentiation and synergizes with differentiating agents in acute myeloid leukemia. J Exp Med. 2010 Apr 12;207(4):731-50. doi: 10.1084/jem.20091488. Epub 2010 Apr 5.
• [205] Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
• [206] Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.
• [207] Screening autism-associated environmental factors in differentiating human neural progenitors with fractional factorial design-based transcriptomics. Sci Rep. 2023 Jun 29;13(1):10519. doi: 10.1038/s41598-023-37488-0.
• [208] Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May;1(3):177-87.
• [209] The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
• [210] Effects of lithium and valproic acid on gene expression and phenotypic markers in an NT2 neurosphere model of neural development. PLoS One. 2013;8(3):e58822.
• [211] Induction of the endoplasmic reticulum stress protein GADD153/CHOP by capsaicin in prostate PC-3 cells: a microarray study. Biochem Biophys Res Commun. 2008 Aug 8;372(4):785-91.
• [212] Zoledronate dysregulates fatty acid metabolism in renal tubular epithelial cells to induce nephrotoxicity. Arch Toxicol. 2018 Jan;92(1):469-485.
• [213] The neuroprotective action of the mood stabilizing drugs lithium chloride and sodium valproate is mediated through the up-regulation of the homeodomain protein Six1. Toxicol Appl Pharmacol. 2009 Feb 15;235(1):124-34.
• [214] Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
• [215] Endoplasmic reticulum stress impairs insulin signaling through mitochondrial damage in SH-SY5Y cells. Neurosignals. 2012;20(4):265-80.
• [216] Delta9-tetrahydrocannabinol inhibits cytotrophoblast cell proliferation and modulates gene transcription. Mol Hum Reprod. 2006 May;12(5):321-33. doi: 10.1093/molehr/gal036. Epub 2006 Apr 5.
• [217] Transcriptional profiling of testosterone-regulated genes in the skeletal muscle of human immunodeficiency virus-infected men experiencing weight loss. J Clin Endocrinol Metab. 2007 Jul;92(7):2793-802. doi: 10.1210/jc.2006-2722. Epub 2007 Apr 17.
• [218] Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
• [219] Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis. Biochem Pharmacol. 2004 Dec 1;68(11):2177-86.
• [220] DNA microarray analysis of vitamin D-induced gene expression in a human colon carcinoma cell line. Physiol Genomics. 2004 Apr 13;17(2):122-9. doi: 10.1152/physiolgenomics.00002.2003.
• [221] Identification of biomarkers and outcomes of endocrine disruption in human ovarian cortex using In Vitro Models. Toxicology. 2023 Feb;485:153425. doi: 10.1016/j.tox.2023.153425. Epub 2023 Jan 5.
• [222] Ornithine decarboxylase antizyme upregulates DNA-dependent protein kinase and enhances the nonhomologous end-joining repair of DNA double-strand breaks in human oral cancer cells. Biochemistry. 2007 Aug 7;46(31):8920-32. doi: 10.1021/bi7000328. Epub 2007 Jul 14.
• [223] Chronic occupational exposure to arsenic induces carcinogenic gene signaling networks and neoplastic transformation in human lung epithelial cells. Toxicol Appl Pharmacol. 2012 Jun 1;261(2):204-16.
• [224] Comparison of the gene expression profiles of monocytic versus granulocytic lineages of HL-60 leukemia cell differentiation by DNA microarray analysis. Life Sci. 2003 Aug 15;73(13):1705-19. doi: 10.1016/s0024-3205(03)00515-0.
• [225] Role of NADPH oxidase in arsenic-induced reactive oxygen species formation and cytotoxicity in myeloid leukemia cells. Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4578-83.
• [226] Pharmacogenomic analysis of acute promyelocytic leukemia cells highlights CYP26 cytochrome metabolism in differential all-trans retinoic acid sensitivity. Blood. 2007 May 15;109(10):4450-60.
• [227] Proteomic and functional analyses reveal a dual molecular mechanism underlying arsenic-induced apoptosis in human multiple myeloma cells. J Proteome Res. 2009 Jun;8(6):3006-19.
• [228] White-to-brown metabolic conversion of human adipocytes by JAK inhibition. Nat Cell Biol. 2015 Jan;17(1):57-67. doi: 10.1038/ncb3075. Epub 2014 Dec 8.
• [229] Consequences of the natural retinoid/retinoid X receptor ligands action in human breast cancer MDA-MB-231 cell line: Focus on functional proteomics. Toxicol Lett. 2017 Nov 5;281:26-34. doi: 10.1016/j.toxlet.2017.09.001. Epub 2017 Sep 5.
• [230] p21(WAF1/cip1) is an important determinant of intestinal cell response to sulindac in vitro and in vivo. Cancer Res. 2001 Aug 15;61(16):6297-302.
• [231] Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells. Tumour Biol. 2011 Oct;32(5):965-76.
• [232] Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation. Blood. 2005 Jul 1;106(1):304-10.
• [233] DNA array analysis of the effects of aspirin on colon cancer cells: involvement of Rac1. Carcinogenesis. 2004 Jul;25(7):1293-8.
• [234] 1,25-Dihydroxyvitamin D3 suppresses gene expression of eukaryotic translation initiation factor 2 in human promyelocytic leukemia HL-60 cells. Cell Struct Funct. 2005;30(1):1-6. doi: 10.1247/csf.30.1.
• [235] Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
• [236] Use of transcriptomics in hazard identification and next generation risk assessment: A case study with clothianidin. Food Chem Toxicol. 2022 Aug;166:113212. doi: 10.1016/j.fct.2022.113212. Epub 2022 Jun 8.
• [237] Identification of mechanisms of action of bisphenol a-induced human preadipocyte differentiation by transcriptional profiling. Obesity (Silver Spring). 2014 Nov;22(11):2333-43.
• [238] The genomic response of a human uterine endometrial adenocarcinoma cell line to 17alpha-ethynyl estradiol. Toxicol Sci. 2009 Jan;107(1):40-55.
• [239] Fulvestrant induces resistance by modulating GPER and CDK6 expression: implication of methyltransferases, deacetylases and the hSWI/SNF chromatin remodelling complex. Br J Cancer. 2013 Nov 12;109(10):2751-62. doi: 10.1038/bjc.2013.583. Epub 2013 Oct 29.
• [240] Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
• [241] Cyclosporine A--induced oxidative stress in human renal mesangial cells: a role for ERK 1/2 MAPK signaling. Toxicol Sci. 2012 Mar;126(1):101-13.
• [242] Cellular zinc homeostasis is a regulator in monocyte differentiation of HL-60 cells by 1 alpha,25-dihydroxyvitamin D3. J Leukoc Biol. 2010 May;87(5):833-44. doi: 10.1189/jlb.0409241. Epub 2010 Jan 20.
• [243] Interleukin-19 as a translational indicator of renal injury. Arch Toxicol. 2015 Jan;89(1):101-6.
• [244] Convergent transcriptional profiles induced by endogenous estrogen and distinct xenoestrogens in breast cancer cells. Carcinogenesis. 2006 Aug;27(8):1567-78.
• [245] Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
• [246] Acute hypersensitivity of pluripotent testicular cancer-derived embryonal carcinoma to low-dose 5-aza deoxycytidine is associated with global DNA Damage-associated p53 activation, anti-pluripotency and DNA demethylation. PLoS One. 2012;7(12):e53003. doi: 10.1371/journal.pone.0053003. Epub 2012 Dec 27.
• [247] LSD1 activates a lethal prostate cancer gene network independently of its demethylase function. Proc Natl Acad Sci U S A. 2018 May 1;115(18):E4179-E4188.
• [248] Regulation of lipocalin-2 gene by the cancer chemopreventive retinoid 4-HPR. Int J Cancer. 2006 Oct 1;119(7):1599-606.
• [249] Cannabidiol induces antioxidant pathways in keratinocytes by targeting BACH1. Redox Biol. 2020 Jan;28:101321. doi: 10.1016/j.redox.2019.101321. Epub 2019 Sep 5.
• [250] Fumarate Mediates a Chronic Proliferative Signal in Fumarate Hydratase-Inactivated Cancer Cells by Increasing Transcription and Translation of Ferritin Genes. Mol Cell Biol. 2017 May 16;37(11):e00079-17. doi: 10.1128/MCB.00079-17. Print 2017 Jun 1.
• [251] Growth-suppressive effect of non-steroidal anti-inflammatory drugs on 11 colon-cancer cell lines and fluorescence differential display of genes whose expression is influenced by sulindac. Int J Cancer. 2000 Dec 15;88(6):873-80. doi: 10.1002/1097-0215(20001215)88:6<873::aid-ijc6>3.0.co;2-b.
• [252] Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
• [253] [Construction of subtracted cDNA library in human Jurkat T cell line induced by arsenic trioxide in vitro]. Zhonghua Yu Fang Yi Xue Za Zhi. 2003 Nov;37(6):403-7.
• [254] Survival of retinal pigment epithelium after exposure to prolonged oxidative injury: a detailed gene expression and cellular analysis. Invest Ophthalmol Vis Sci. 2004 Oct;45(10):3767-77.
• [255] Single-cell Transcriptome Mapping Identifies Common and Cell-type Specific Genes Affected by Acute Delta9-tetrahydrocannabinol in Humans. Sci Rep. 2020 Feb 26;10(1):3450. doi: 10.1038/s41598-020-59827-1.
• [256] Gene-specific TCDD suppression of RARalpha- and RXR-mediated induction of tissue transglutaminase. Toxicol Sci. 2002 Jul;68(1):102-8. doi: 10.1093/toxsci/68.1.102.
• [257] TCDD suppression of tissue transglutaminase stimulation by retinoids in malignant human keratinocytes. Toxicol Sci. 2000 Aug;56(2):357-64.
• [258] Inter-laboratory comparison of human renal proximal tubule (HK-2) transcriptome alterations due to Cyclosporine A exposure and medium exhaustion. Toxicol In Vitro. 2009 Apr;23(3):486-99.
• [259] NF-kappaB-activated tissue transglutaminase is involved in ethanol-induced hepatic injury and the possible role of propolis in preventing fibrogenesis. Toxicology. 2008 Apr 18;246(2-3):148-57.
• [260] PPARgamma controls CD1d expression by turning on retinoic acid synthesis in developing human dendritic cells. J Exp Med. 2006 Oct 2;203(10):2351-62.
• [261] MS4A3-HSP27 target pathway reveals potential for haematopoietic disorder treatment in alimentary toxic aleukia. Cell Biol Toxicol. 2023 Feb;39(1):201-216. doi: 10.1007/s10565-021-09639-4. Epub 2021 Sep 28.
• [262] Methotrexate modulates folate phenotype and inflammatory profile in EA.hy 926 cells. Eur J Pharmacol. 2014 Jun 5;732:60-7.
• [263] Cdk4/6 inhibition induces epithelial-mesenchymal transition and enhances invasiveness in pancreatic cancer cells. Mol Cancer Ther. 2012 Oct;11(10):2138-48. doi: 10.1158/1535-7163.MCT-12-0562. Epub 2012 Aug 6.
• [264] Short-chain fatty acids enhance nuclear receptor activity through mitogen-activated protein kinase activation and histone deacetylase inhibition. Proc Natl Acad Sci U S A. 2004 May 4;101(18):7199-204.
• [265] Proteomic analysis of human adipose tissue after rosiglitazone treatment shows coordinated changes to promote glucose uptake. Obesity (Silver Spring). 2010 Jan;18(1):27-34. doi: 10.1038/oby.2009.208. Epub 2009 Jun 25.
• [266] ERE-independent ERalpha target genes differentially expressed in human breast tumors. Mol Cell Endocrinol. 2005 Dec 21;245(1-2):53-9. doi: 10.1016/j.mce.2005.10.003. Epub 2005 Nov 17.
• [267] Retinoic acid and its 4-oxo metabolites are functionally active in human skin cells in vitro. J Invest Dermatol. 2005 Jul;125(1):143-53.
• [268] [Effects of As2O3 on tissue factor, plasminogen activator inhibitor-1 and -2 expression in NB4, HL-60 and THP-1 cells]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2003 Oct;34(4):645-9.
• [269] Effects of aspirin on metastasis-associated gene expression detected by cDNA microarray. Acta Pharmacol Sin. 2004 Oct;25(10):1327-33.
• [270] JunD is involved in the antiproliferative effect of Delta9-tetrahydrocannabinol on human breast cancer cells. Oncogene. 2008 Aug 28;27(37):5033-44.
• [271] Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells. Toxicol Sci. 2023 Feb 17;191(2):227-238. doi: 10.1093/toxsci/kfac131.
• [272] Identification of genes linked to gefitinib treatment in prostate cancer cell lines with or without resistance to androgen: a clue to application of gefitinib to hormone-resistant prostate cancer. Oncol Rep. 2006 Jun;15(6):1453-60.
• [273] XPC is essential for nucleotide excision repair of zidovudine-induced DNA damage in human hepatoma cells. Toxicol Appl Pharmacol. 2011 Mar 1;251(2):155-62. doi: 10.1016/j.taap.2010.12.009. Epub 2010 Dec 28.
• [274] Cannabidiol Displays Proteomic Similarities to Antipsychotics in Cuprizone-Exposed Human Oligodendrocytic Cell Line MO3.13. Front Mol Neurosci. 2021 May 28;14:673144. doi: 10.3389/fnmol.2021.673144. eCollection 2021.
• [275] Comparative gene expression profiling reveals partially overlapping but distinct genomic actions of different antiestrogens in human breast cancer cells. J Cell Biochem. 2006 Aug 1;98(5):1163-84.
• [276] In-vivo effects of simvastatin and rosuvastatin on global gene expression in peripheral blood leucocytes in a human inflammation model. Pharmacogenet Genomics. 2008 Feb;18(2):109-20.
• [277] Arsenic promotes the COX2/PGE2-SOX2 axis to increase the malignant stemness properties of urothelial cells. Int J Cancer. 2018 Jul 1;143(1):113-126.
• [278] Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen. Clin Pharmacol Ther. 2016 Apr;99(4):432-41.
• [279] Rofecoxib modulates multiple gene expression pathways in a clinical model of acute inflammatory pain. Pain. 2007 Mar;128(1-2):136-47.
• [280] Gene expression profiling in Ishikawa cells: a fingerprint for estrogen active compounds. Toxicol Appl Pharmacol. 2009 Apr 1;236(1):85-96.
• [281] Genistein and bisphenol A exposure cause estrogen receptor 1 to bind thousands of sites in a cell type-specific manner. Genome Res. 2012 Nov;22(11):2153-62.
• [282] Arsenite and cadmium promote the development of mammary tumors. Carcinogenesis. 2020 Jul 14;41(7):1005-1014. doi: 10.1093/carcin/bgz176.
• [283] Changes in gene expression profiles of multiple myeloma cells induced by arsenic trioxide (ATO): possible mechanisms to explain ATO resistance in vivo. Br J Haematol. 2005 Mar;128(5):636-44.
• [284] Stem cell transcriptome responses and corresponding biomarkers that indicate the transition from adaptive responses to cytotoxicity. Chem Res Toxicol. 2017 Apr 17;30(4):905-922.
• [285] The effect of folic acid deficiency on Mest/Peg1 in neural tube defects. Int J Neurosci. 2021 May;131(5):468-477. doi: 10.1080/00207454.2020.1750386. Epub 2020 Apr 16.
• [286] Apoptosis induced by piroxicam plus cisplatin combined treatment is triggered by p21 in mesothelioma. PLoS One. 2011;6(8):e23569.
• [287] Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses. PLoS One. 2010 Dec 17;5(12):e14352. doi: 10.1371/journal.pone.0014352.
• [288] Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761. doi: 10.1016/j.taap.2019.114761. Epub 2019 Sep 15.
• [289] Gene expression in endometrial cancer cells (Ishikawa) after short time high dose exposure to progesterone. Steroids. 2008 Jan;73(1):116-28.
• [290] Cytosine arabinoside induces ectoderm and inhibits mesoderm expression in human embryonic stem cells during multilineage differentiation. Br J Pharmacol. 2011 Apr;162(8):1743-56.
• [291] Synergistic effects of arsenic trioxide combined with ascorbic acid in human osteosarcoma MG-63 cells: a systems biology analysis. Eur Rev Med Pharmacol Sci. 2014;18(24):3877-88.
• [292] Drinking-water arsenic exposure modulates gene expression in human lymphocytes from a U.S. population. Environ Health Perspect. 2008 Apr;116(4):524-31. doi: 10.1289/ehp.10861.
• [293] Pleiotropic combinatorial transcriptomes of human breast cancer cells exposed to mixtures of dietary phytoestrogens. Food Chem Toxicol. 2009 Apr;47(4):787-95.
• [294] Reproducible chemical-induced changes in gene expression profiles in human hepatoma HepaRG cells under various experimental conditions. Toxicol In Vitro. 2009 Apr;23(3):466-75. doi: 10.1016/j.tiv.2008.12.018. Epub 2008 Dec 30.
• [295] Effect of all-trans retinoic acid on sodium/iodide symporter expression, radioiodine uptake and gene expression profiles in a human anaplastic thyroid carcinoma cell line. Nucl Med Biol. 2006 Oct;33(7):875-82. doi: 10.1016/j.nucmedbio.2006.07.004.
• [296] Simvastatin inactivates beta1-integrin and extracellular signal-related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells. Cancer Sci. 2007 Jun;98(6):890-9.
• [297] Inhibition of prostate cancer cell colony formation by the flavonoid quercetin correlates with modulation of specific regulatory genes. Clin Diagn Lab Immunol. 2004 Jan;11(1):63-9. doi: 10.1128/cdli.11.1.63-69.2004.
• [298] The proapoptotic effect of zoledronic acid is independent of either the bone microenvironment or the intrinsic resistance to bortezomib of myeloma cells and is enhanced by the combination with arsenic trioxide. Exp Hematol. 2011 Jan;39(1):55-65.
• [299] Molecular mechanisms of hepatotoxic cholestasis by clavulanic acid: Role of NRF2 and FXR pathways. Food Chem Toxicol. 2021 Dec;158:112664. doi: 10.1016/j.fct.2021.112664. Epub 2021 Nov 9.
• [300] Antidepressant drugs activate SREBP and up-regulate cholesterol and fatty acid biosynthesis in human glial cells. Neurosci Lett. 2006 Mar 13;395(3):185-90. doi: 10.1016/j.neulet.2005.10.096. Epub 2005 Dec 1.
• [301] Effects of four-week high-fructose diet on gene expression in skeletal muscle of healthy men. Diabetes Metab. 2008 Feb;34(1):82-5. doi: 10.1016/j.diabet.2007.08.004. Epub 2007 Dec 11.
• [302] Proteomics-based identification of differentially abundant proteins from human keratinocytes exposed to arsenic trioxide. J Proteomics Bioinform. 2014 Jul;7(7):166-178.
• [303] THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders. Transl Psychiatry. 2018 Apr 25;8(1):89. doi: 10.1038/s41398-018-0137-3.
• [304] Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21.
• [305] Cytosolic proteomic alterations in the nucleus accumbens of cocaine overdose victims. Mol Psychiatry. 2007 Jan;12(1):55-73. doi: 10.1038/sj.mp.4001914. Epub 2006 Oct 31.
• [306] Low doses of cisplatin induce gene alterations, cell cycle arrest, and apoptosis in human promyelocytic leukemia cells. Biomark Insights. 2016 Aug 24;11:113-21.
• [307] Gene expression in human hippocampus from cocaine abusers identifies genes which regulate extracellular matrix remodeling. PLoS One. 2007 Nov 14;2(11):e1187. doi: 10.1371/journal.pone.0001187.
• [308] Systems analysis of transcriptome and proteome in retinoic acid/arsenic trioxide-induced cell differentiation/apoptosis of promyelocytic leukemia. Proc Natl Acad Sci U S A. 2005 May 24;102(21):7653-8.
• [309] Ouabain at pathological concentrations might induce damage in human vascular endothelial cells. Acta Pharmacol Sin. 2006 Feb;27(2):165-72. doi: 10.1111/j.1745-7254.2006.00244.x.
• [310] Clinical determinants of response to irinotecan-based therapy derived from cell line models. Clin Cancer Res. 2008 Oct 15;14(20):6647-55.
• [311] Exposure to Insecticides Modifies Gene Expression and DNA Methylation in Hematopoietic Tissues In Vitro. Int J Mol Sci. 2023 Mar 26;24(7):6259. doi: 10.3390/ijms24076259.
• [312] Hypoxia-inducible factor-1 (HIF-1) pathway activation by quercetin in human lens epithelial cells. Exp Eye Res. 2009 Dec;89(6):995-1002. doi: 10.1016/j.exer.2009.08.011. Epub 2009 Sep 1.
• [313] Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
• [314] Transcriptomic analysis of untreated and drug-treated differentiated HepaRG cells over a 2-week period. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):27-35.
• [315] Transcriptome and DNA methylome dynamics during triclosan-induced cardiomyocyte differentiation toxicity. Stem Cells Int. 2018 Oct 29;2018:8608327.
• [316] From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. Arch Toxicol. 2014 Jul;88(7):1451-68.
• [317] Sex hormones and gene expression signatures in peripheral blood from postmenopausal women - the NOWAC postgenome study. BMC Med Genomics. 2011 Mar 31;4:29. doi: 10.1186/1755-8794-4-29.
• [318] Identification of transcriptome signatures and biomarkers specific for potential developmental toxicants inhibiting human neural crest cell migration. Arch Toxicol. 2016 Jan;90(1):159-80.
• [319] Mitochondrial Uncoupling Induces Epigenome Remodeling and Promotes Differentiation in Neuroblastoma. Cancer Res. 2023 Jan 18;83(2):181-194. doi: 10.1158/0008-5472.CAN-22-1029.
• [320] Mutant p53 reactivation by PRIMA-1MET induces multiple signaling pathways converging on apoptosis. Oncogene. 2010 Mar 4;29(9):1329-38. doi: 10.1038/onc.2009.425. Epub 2009 Nov 30.
• [321] Retinoic acid-induced downmodulation of telomerase activity in human cancer cells. Exp Mol Pathol. 2005 Oct;79(2):108-17.
• [322] Identification of biomarkers modulated by the rexinoid LGD1069 (bexarotene) in human breast cells using oligonucleotide arrays. Cancer Res. 2006 Dec 15;66(24):12009-18.
• [323] Chemical genomic screening for methylation-silenced genes in gastric cancer cell lines using 5-aza-2'-deoxycytidine treatment and oligonucleotide microarray. Cancer Sci. 2006 Jan;97(1):64-71.
• [324] Proteomic analysis revealed association of aberrant ROS signaling with suberoylanilide hydroxamic acid-induced autophagy in Jurkat T-leukemia cells. Autophagy. 2010 Aug;6(6):711-24. doi: 10.4161/auto.6.6.12397. Epub 2010 Aug 17.
• [325] Manganese superoxide dismutase induces migration and invasion of tongue squamous cell carcinoma via H2O2-dependent Snail signaling. Free Radic Biol Med. 2012 Jul 1;53(1):44-50. doi: 10.1016/j.freeradbiomed.2012.04.031. Epub 2012 May 9.
• [326] Nitric oxide causes anoikis through attenuation of E-cadherin and activation of caspase-3 in human gastric carcinoma AZ-521 cells infected with Mycoplasma hyorhinis. J Vet Med Sci. 2010 Jul;72(7):869-74.
• [327] Induced differentiation in HT29, a human colon adenocarcinoma cell line. J Cell Sci. 1999 Aug;112 ( Pt 16):2657-66. doi: 10.1242/jcs.112.16.2657.
• [328] Antitumoral activity of liraglutide, a new DNMT inhibitor in breast cancer cells in vitro and in vivo. Chem Biol Interact. 2021 Nov 1;349:109641. doi: 10.1016/j.cbi.2021.109641. Epub 2021 Sep 14.
• [329] Troglitazone increases expression of E-cadherin and claudin 4 in human pancreatic cancer cells. Biochem Biophys Res Commun. 2009 Mar 13;380(3):614-9. doi: 10.1016/j.bbrc.2009.01.134. Epub 2009 Jan 27.
• [330] Regulation of epithelial cell morphology and functions approaching to more in vivo-like by modifying polyethylene glycol on polysulfone membranes. PLoS One. 2012;7(4):e36110.
• [331] HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin. Nat Genet. 2009 Jul;41(7):816-9. doi: 10.1038/ng.379. Epub 2009 May 31.
• [332] Polymerase I and transcript release factor (PTRF)/cavin-1 is a novel regulator of stress-induced premature senescence. J Biol Chem. 2011 Aug 19;286(33):28657-28661. doi: 10.1074/jbc.C111.235119. Epub 2011 Jun 24.
• [333] Identification of novel gene targets and putative regulators of arsenic-associated DNA methylation in human urothelial cells and bladder cancer. Chem Res Toxicol. 2015 Jun 15;28(6):1144-55. doi: 10.1021/tx500393y. Epub 2015 Jun 3.
• [334] Resveratrol modifies the expression of apoptotic regulatory proteins and sensitizes non-Hodgkin's lymphoma and multiple myeloma cell lines to paclitaxel-induced apoptosis. Mol Cancer Ther. 2004 Jan;3(1):71-84.
• [335] Neurokinin-1 receptor (NK1R) inhibition sensitizes APL cells to anti-tumor effect of arsenic trioxide via restriction of NF-B axis: Shedding new light on resistance to Aprepitant. Int J Biochem Cell Biol. 2018 Oct;103:105-114. doi: 10.1016/j.biocel.2018.08.010. Epub 2018 Aug 23.
• [336] Simvastatin induces apoptosis in human colon cancer cells and in tumor xenografts, and attenuates colitis-associated colon cancer in mice. Int J Cancer. 2008 Aug 15;123(4):951-7. doi: 10.1002/ijc.23593.
• [337] Benzodithiophenes potentiate differentiation of acute promyelocytic leukemia cells by lowering the threshold for ligand-mediated corepressor/coactivator exchange with retinoic acid receptor alpha and enhancing changes in all-trans-retinoic acid-regulated gene expression. Cancer Res. 2005 Sep 1;65(17):7856-65. doi: 10.1158/0008-5472.CAN-05-1056.
• [338] Antitumor action of the MET tyrosine kinase inhibitor crizotinib (PF-02341066) in gastric cancer positive for MET amplification. Mol Cancer Ther. 2012 Jul;11(7):1557-64. doi: 10.1158/1535-7163.MCT-11-0934. Epub 2012 Jun 22.
• [339] The antipsychotic chlorpromazine suppresses YAP signaling, stemness properties, and drug resistance in breast cancer cells. Chem Biol Interact. 2019 Apr 1;302:28-35. doi: 10.1016/j.cbi.2019.01.033. Epub 2019 Jan 28.
• [340] Inhibition of PI3K pathway using BKM120 intensified the chemo-sensitivity of breast cancer cells to arsenic trioxide (ATO). Int J Biochem Cell Biol. 2019 Nov;116:105615. doi: 10.1016/j.biocel.2019.105615. Epub 2019 Sep 17.
• [341] The hepatotoxic fluoroquinolone trovafloxacin disturbs TNF- and LPS-induced p65 nuclear translocation in vivo and in vitro. Toxicol Appl Pharmacol. 2020 Mar 15;391:114915. doi: 10.1016/j.taap.2020.114915. Epub 2020 Feb 6.
• [342] Etodolac inhibits EBER expression and induces Bcl-2-regulated apoptosis in Burkitt's lymphoma cells. Eur J Haematol. 2005 Sep;75(3):212-20. doi: 10.1111/j.1600-0609.2005.00498.x.
• [343] Apoptosis induction by 1alpha,25-dihydroxyvitamin D3 in prostate cancer. Mol Cancer Ther. 2002 Jul;1(9):667-77.
• [344] New insights into BaP-induced toxicity: role of major metabolites in transcriptomics and contribution to hepatocarcinogenesis. Arch Toxicol. 2016 Jun;90(6):1449-58.
• [345] Expression and DNA methylation changes in human breast epithelial cells after bisphenol A exposure. Int J Oncol. 2012 Jul;41(1):369-77.
• [346] Suppression of mammary carcinoma growth by retinoic acid: proapoptotic genes are targets for retinoic acid receptor and cellular retinoic acid-binding protein II signaling. Cancer Res. 2005 Sep 15;65(18):8193-9. doi: 10.1158/0008-5472.CAN-05-1177.
• [347] Enhancement of the antiproliferative activity of gemcitabine by modulation of c-Met pathway in pancreatic cancer. Curr Pharm Des. 2013;19(5):940-50.
• [348] Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell. 2009 Aug 21;138(4):645-659. doi: 10.1016/j.cell.2009.06.034. Epub 2009 Aug 13.
• [349] Methylation status of the Ep-CAM promoter region in human breast cancer cell lines and breast cancer tissue. Cancer Lett. 2007 Feb 8;246(1-2):253-61. doi: 10.1016/j.canlet.2006.03.002. Epub 2006 Apr 18.
• [350] Inhibiting Heat Shock Proteins Can Potentiate the Cytotoxic Effect of Cannabidiol in Human Glioma Cells. Anticancer Res. 2015 Nov;35(11):5827-37.
• [351] Gene expression profiling of rheumatoid arthritis synovial cells treated with antirheumatic drugs. J Biomol Screen. 2007 Apr;12(3):328-40. doi: 10.1177/1087057107299261. Epub 2007 Mar 22.
• [352] Identification of troglitazone responsive genes: induction of RTP801 during troglitazone-induced apoptosis in Hep 3B cells. BMB Rep. 2010 Sep;43(9):599-603. doi: 10.5483/BMBRep.2010.43.9.599.
• [353] In vitro effects of aldehydes present in tobacco smoke on gene expression in human lung alveolar epithelial cells. Toxicol In Vitro. 2013 Apr;27(3):1072-81.
• [354] Oxidative Stress-Protective and Anti-Melanogenic Effects of Loliolide and Ethanol Extract from Fresh Water Green Algae, Prasiola japonica. Int J Mol Sci. 2018 Sep 18;19(9):2825. doi: 10.3390/ijms19092825.
• [355] The effects of a novel synthetic retinoid, seletinoid G, on the expression of extracellular matrix proteins in aged human skin in vivo. Clin Chim Acta. 2005 Dec;362(1-2):161-9. doi: 10.1016/j.cccn.2005.06.016. Epub 2005 Aug 1.
• [356] Ciprofloxacin enhances the stimulation of matrix metalloproteinase 3 expression by interleukin-1beta in human tendon-derived cells. A potential mechanism of fluoroquinolone-induced tendinopathy. Arthritis Rheum. 2002 Nov;46(11):3034-40. doi: 10.1002/art.10617.
• [357] Simvastatin reduces MMP1 expression in human smooth muscle cells cultured on polymerized collagen by inhibiting Rac1 activation. Arterioscler Thromb Vasc Biol. 2007 May;27(5):1043-9. doi: 10.1161/ATVBAHA.107.139881. Epub 2007 Feb 15.
• [358] Quercetin inhibits matrix metalloproteinase-1 expression in human vascular endothelial cells through extracellular signal-regulated kinase. Arch Biochem Biophys. 2001 Jul 1;391(1):72-8. doi: 10.1006/abbi.2001.2402.
• [359] Rofecoxib regulates the expression of genes related to the matrix metalloproteinase pathway in humans: implication for the adverse effects of cyclooxygenase-2 inhibitors. Clin Pharmacol Ther. 2006 Apr;79(4):303-15. doi: 10.1016/j.clpt.2005.12.306.
• [360] Interaction between the aryl hydrocarbon receptor and retinoic acid pathways increases matrix metalloproteinase-1 expression in keratinocytes. J Biol Chem. 2004 Jun 11;279(24):25284-93. doi: 10.1074/jbc.M402168200. Epub 2004 Apr 9.
• [361] Gene expression profile induced by arsenic trioxide in chronic lymphocytic leukemia cells reveals a central role for heme oxygenase-1 in apoptosis and regulation of matrix metalloproteinase-9. Oncotarget. 2016 Dec 13;7(50):83359-83377.
• [362] mTOR inhibition reverses acquired endocrine therapy resistance of breast cancer cells at the cell proliferation and gene-expression levels. Cancer Sci. 2008 Oct;99(10):1992-2003. doi: 10.1111/j.1349-7006.2008.00955.x.
• [363] CyclinB2 and BIRC5 genes as surrogate biomarkers for neurite outgrowth in SH-SY5Y subclonal cells. Neuropharmacology. 2006 Jun;50(8):1041-7. doi: 10.1016/j.neuropharm.2006.02.004. Epub 2006 Mar 30.
• [364] Effects of chlorpromazine with and without UV irradiation on gene expression of HepG2 cells. Mutat Res. 2005 Aug 4;575(1-2):47-60. doi: 10.1016/j.mrfmmm.2005.03.002. Epub 2005 Apr 26.
• [365] Gene expression profile changes in NB4 cells induced by arsenic trioxide. Acta Pharmacol Sin. 2003 Jul;24(7):646-50.
• [366] The cyclooxygenase inhibitor indomethacin modulates gene expression and represses the extracellular matrix protein laminin gamma1 in human glioblastoma cells. Exp Cell Res. 2005 Jan 15;302(2):244-52. doi: 10.1016/j.yexcr.2004.09.021.
• [367] Moving toward integrating gene expression profiling into high-throughput testing: a gene expression biomarker accurately predicts estrogen receptor alpha modulation in a microarray compendium. Toxicol Sci. 2016 May;151(1):88-103.
• [368] Gene expression profile of human lymphoid CEM cells sensitive and resistant to glucocorticoid-evoked apoptosis. Genomics. 2003 Jun;81(6):543-55.
• [369] The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells. Leukemia. 2009 Jun;23(6):1019-28.
• [370] Activin/nodal signaling switches the terminal fate of human embryonic stem cell-derived trophoblasts. J Biol Chem. 2015 Apr 3;290(14):8834-48.
• [371] Bisphenol-A and estradiol exert novel gene regulation in human MCF-7 derived breast cancer cells. Mol Cell Endocrinol. 2004 Jun 30;221(1-2):47-55. doi: 10.1016/j.mce.2004.04.010.
• [372] Molecular mechanisms of quercitrin-induced apoptosis in non-small cell lung cancer. Arch Med Res. 2014 Aug;45(6):445-54.
• [373] Drug-induced endoplasmic reticulum and oxidative stress responses independently sensitize toward TNF-mediated hepatotoxicity. Toxicol Sci. 2014 Jul;140(1):144-59. doi: 10.1093/toxsci/kfu072. Epub 2014 Apr 20.
• [374] Linalool is a PPARalpha ligand that reduces plasma TG levels and rewires the hepatic transcriptome and plasma metabolome. J Lipid Res. 2014 Jun;55(6):1098-110.
• [375] Growth inhibition of ovarian tumor-initiating cells by niclosamide. Mol Cancer Ther. 2012 Aug;11(8):1703-12.
• [376] Genistein disrupts glucocorticoid receptor signaling in human uterine endometrial Ishikawa cells. Environ Health Perspect. 2015 Jan;123(1):80-7. doi: 10.1289/ehp.1408437. Epub 2014 Aug 19.
• [377] Association of Arsenic Exposure with Whole Blood DNA Methylation: An Epigenome-Wide Study of Bangladeshi Adults. Environ Health Perspect. 2019 May;127(5):57011. doi: 10.1289/EHP3849. Epub 2019 May 28.
• [378] Redistribution of cell cycle by arsenic trioxide is associated with demethylation and expression changes of cell cycle related genes in acute promyelocytic leukemia cell line (NB4). Ann Hematol. 2018 Jan;97(1):83-93. doi: 10.1007/s00277-017-3163-y. Epub 2017 Nov 20.
• [379] Clarifying off-target effects for torcetrapib using network pharmacology and reverse docking approach. BMC Syst Biol. 2012 Dec 10;6:152.
• [380] Bisphenol A induces DSB-ATM-p53 signaling leading to cell cycle arrest, senescence, autophagy, stress response, and estrogen release in human fetal lung fibroblasts. Arch Toxicol. 2018 Apr;92(4):1453-1469.
• [381] Propofol suppresses proliferation, migration, invasion, and tumor growth of liver cancer cells via suppressing cancer susceptibility candidate 9/phosphatase and tensin homolog/AKT serine/threonine kinase/mechanistic target of rapamycin kinase axis. Hum Exp Toxicol. 2022 Jan-Dec;41:9603271211065972. doi: 10.1177/09603271211065972.
• [382] Constitutive gene expression predisposes morphogen-mediated cell fate responses of NT2/D1 and 27X-1 human embryonal carcinoma cells. Stem Cells. 2007 Mar;25(3):771-8. doi: 10.1634/stemcells.2006-0271. Epub 2006 Nov 30.
• [383] Identification of differentially expressed genes in hepatic HepG2 cells treated with acetaminophen using suppression subtractive hybridization. Biol Pharm Bull. 2005 Jul;28(7):1148-53. doi: 10.1248/bpb.28.1148.
• [384] Effect of aflatoxin B(1), benzo[a]pyrene, and methapyrilene on transcriptomic and epigenetic alterations in human liver HepaRG cells. Food Chem Toxicol. 2018 Nov;121:214-223. doi: 10.1016/j.fct.2018.08.034. Epub 2018 Aug 26.
• [385] Gene expression profile analysis of gallic acid-induced cell death process. Sci Rep. 2021 Aug 18;11(1):16743. doi: 10.1038/s41598-021-96174-1.
• [386] Inorganic arsenic exposure promotes malignant progression by HDAC6-mediated down-regulation of HTRA1. J Appl Toxicol. 2023 Aug;43(8):1214-1224. doi: 10.1002/jat.4457. Epub 2023 Mar 11.
• [387] RNA sequence analysis of inducible pluripotent stem cell-derived cardiomyocytes reveals altered expression of DNA damage and cell cycle genes in response to doxorubicin. Toxicol Appl Pharmacol. 2018 Oct 1;356:44-53.
• [388] Cardiac toxicity from ethanol exposure in human-induced pluripotent stem cell-derived cardiomyocytes. Toxicol Sci. 2019 May 1;169(1):280-292.
• [389] Dasatinib reverses cancer-associated fibroblasts (CAFs) from primary lung carcinomas to a phenotype comparable to that of normal fibroblasts. Mol Cancer. 2010 Jun 27;9:168.
• [390] Effects of progesterone treatment on expression of genes involved in uterine quiescence. Reprod Sci. 2011 Aug;18(8):781-97.
• [391] Microarray-based detection and expression analysis of extracellular matrix proteins in drug?resistant ovarian cancer cell lines. Oncol Rep. 2014 Nov;32(5):1981-90. doi: 10.3892/or.2014.3468. Epub 2014 Sep 9.
• [392] Transcriptional signature of human macrophages exposed to the environmental contaminant benzo(a)pyrene. Toxicol Sci. 2010 Apr;114(2):247-59.
• [393] Endoplasmic reticulum stress contributes to arsenic trioxide-induced intrinsic apoptosis in human umbilical and bone marrow mesenchymal stem cells. Environ Toxicol. 2016 Mar;31(3):314-28.
• [394] Environmental pollutant induced cellular injury is reflected in exosomes from placental explants. Placenta. 2020 Jan 1;89:42-49. doi: 10.1016/j.placenta.2019.10.008. Epub 2019 Oct 17.
• [395] Gene expression changes in primary human nasal epithelial cells exposed to formaldehyde in vitro. Toxicol Lett. 2010 Oct 5;198(2):289-95.
• [396] An approach to elucidate potential mechanism of renal toxicity of arsenic trioxide. Exp Hematol. 2007 Feb;35(2):252-62.
• [397] Folate deficiency in normal human fibroblasts leads to altered expression of genes primarily linked to cell signaling, the cytoskeleton and extracellular matrix. J Nutr Biochem. 2007 Aug;18(8):541-52. doi: 10.1016/j.jnutbio.2006.11.002. Epub 2007 Feb 22.
• [398] Isoproterenol effects evaluated in heart slices of human and rat in comparison to rat heart in vivo. Toxicol Appl Pharmacol. 2014 Jan 15;274(2):302-12.
• [399] Peroxisome proliferator activated receptor gamma (PPAR-gama) ligand pioglitazone regulated gene networks in term human primary trophoblast cells. Reprod Toxicol. 2018 Oct;81:99-107.
• [400] Quercetin induced cell apoptosis and altered gene expression in AGS human gastric cancer cells. Environ Toxicol. 2018 Nov;33(11):1168-1181. doi: 10.1002/tox.22623. Epub 2018 Aug 27.
• [401] Soy isoflavones exert differential effects on androgen responsive genes in LNCaP human prostate cancer cells. J Nutr. 2007 Apr;137(4):964-72.
• [402] Differential effects of estrogen and progesterone on potassium channels expressed in Xenopus oocytes. Steroids. 2008 Mar;73(3):272-9. doi: 10.1016/j.steroids.2007.10.010. Epub 2007 Nov 4.
• [403] Estradiol and selective estrogen receptor modulators differentially regulate target genes with estrogen receptors alpha and beta. Mol Biol Cell. 2004 Mar;15(3):1262-72. doi: 10.1091/mbc.e03-06-0360. Epub 2003 Dec 29.
• [404] Oxyresveratrol stimulates mucin production in an NAD+-dependent manner in human intestinal goblet cells. Food Chem Toxicol. 2018 Aug;118:880-888.
• [405] Cannabidiol Modulates the Immunophenotype and Inhibits the Activation of the Inflammasome in Human Gingival Mesenchymal Stem Cells. Front Physiol. 2016 Nov 24;7:559. doi: 10.3389/fphys.2016.00559. eCollection 2016.
• [406] Death receptor 5 regulation during selenium-mediated apoptosis in human prostate cancer cells. Cancer Biol Ther. 2002 May-Jun;1(3):287-90. doi: 10.4161/cbt.83.
• [407] Quercetin potentiates apoptosis by inhibiting nuclear factor-kappaB signaling in H460 lung cancer cells. Biol Pharm Bull. 2013;36(6):944-51. doi: 10.1248/bpb.b12-01004.
• [408] Combination of Poly I:C and arsenic trioxide triggers apoptosis synergistically via activation of TLR3 and mitochondrial pathways in hepatocellular carcinoma cells. Cell Biol Int. 2011 Aug;35(8):803-10. doi: 10.1042/CBI20100739.
• [409] Role of mitochondria in aspirin-induced apoptosis in human gastric epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2005 Oct;289(4):G731-8. doi: 10.1152/ajpgi.00150.2005. Epub 2005 Jun 23.
• [410] p38 MAPK/PP2Ac/TTP pathway on the connection of TNF- and caspases activation on hydroquinone-induced apoptosis. Carcinogenesis. 2013 Apr;34(4):818-27. doi: 10.1093/carcin/bgs409. Epub 2013 Jan 3.
• [411] [Hypermethylation of CpG island of DLC-1 gene and arsenic trioxide-induced DLC-1 gene demethylation in multiple myeloma]. Zhonghua Yi Xue Za Zhi. 2014 Sep 30;94(36):2816-21.
• [412] Ursodeoxycholic acid-induced inhibition of DLC1 protein degradation leads to suppression of hepatocellular carcinoma cell growth. Oncol Rep. 2011 Jun;25(6):1739-46. doi: 10.3892/or.2011.1239. Epub 2011 Mar 29.
• [413] Effects of paclitaxel on proliferation and apoptosis in human acute myeloid leukemia HL-60 cells. Acta Pharmacol Sin. 2004 Mar;25(3):378-84.
• [414] Epigenetic changes in individuals with arsenicosis. Chem Res Toxicol. 2011 Feb 18;24(2):165-7. doi: 10.1021/tx1004419. Epub 2011 Feb 4.
• [415] Induction of APOBEC3C Facilitates the Genotoxic Stress-Mediated Cytotoxicity of Artesunate. Chem Res Toxicol. 2019 Dec 16;32(12):2526-2537. doi: 10.1021/acs.chemrestox.9b00358. Epub 2019 Nov 11.
• [416] Changes in gene expression profiles in response to selenium supplementation among individuals with arsenic-induced pre-malignant skin lesions. Toxicol Lett. 2007 Mar 8;169(2):162-76. doi: 10.1016/j.toxlet.2007.01.006. Epub 2007 Jan 19.
• [417] Arsenic and fluoride induce apoptosis, inflammation and oxidative stress in cultured human umbilical vein endothelial cells. Chemosphere. 2017 Jan;167:454-461. doi: 10.1016/j.chemosphere.2016.10.025. Epub 2016 Oct 14.
• [418] Synergistic antiproliferative effect of arsenic trioxide combined with bortezomib in HL60 cell line and primary blasts from patients affected by myeloproliferative disorders. Cancer Genet Cytogenet. 2010 Jun;199(2):110-20. doi: 10.1016/j.cancergencyto.2010.02.010.
• [419] Biological specificity of CDK4/6 inhibitors: dose response relationship, in vivo signaling, and composite response signature. Oncotarget. 2017 Jul 4;8(27):43678-43691. doi: 10.18632/oncotarget.18435.
• [420] Effect of retinoic acid on gene expression in human conjunctival epithelium: secretory phospholipase A2 mediates retinoic acid induction of MUC16. Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4050-61.
• [421] Extremely low copper concentrations affect gene expression profiles of human prostate epithelial cell lines. Chem Biol Interact. 2010 Oct 6;188(1):214-9.
• [422] Mitomycin C induces apoptosis in cultured corneal fibroblasts derived from type II granular corneal dystrophy corneas. Mol Vis. 2008 Jun 30;14:1222-8.
• [423] Characterization of DOK1, a candidate tumor suppressor gene, in epithelial ovarian cancer. Mol Oncol. 2011 Oct;5(5):438-53. doi: 10.1016/j.molonc.2011.07.003. Epub 2011 Jul 26.
• [424] Isobaric tags for relative and absolute quantitation-based proteomics analysis of the effect of ginger oil on bisphenol A-induced breast cancer cell proliferation. Oncol Lett. 2021 Feb;21(2):101. doi: 10.3892/ol.2020.12362. Epub 2020 Dec 8.
• [425] Quantitative proteomic analysis of HepG2 cells treated with quercetin suggests IQGAP1 involved in quercetin-induced regulation of cell proliferation and migration. OMICS. 2009 Apr;13(2):93-103. doi: 10.1089/omi.2008.0075.
• [426] Metformin blocks migration and invasion of tumour cells by inhibition of matrix metalloproteinase-9 activation through a calcium and protein kinase Calpha-dependent pathway: phorbol-12-myristate-13-acetate-induced/extracellular signal-regulated kinase/activator protein-1. Br J Pharmacol. 2010 Jul;160(5):1195-211. doi: 10.1111/j.1476-5381.2010.00762.x.
• [427] High-throughput ectopic expression screen for tamoxifen resistance identifies an atypical kinase that blocks autophagy. Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):2058-63.
• [428] Suppression of HER2/HER3-mediated growth of breast cancer cells with combinations of GDC-0941 PI3K inhibitor, trastuzumab, and pertuzumab. Clin Cancer Res. 2009 Jun 15;15(12):4147-56. doi: 10.1158/1078-0432.CCR-08-2814. Epub 2009 Jun 9.
• [429] Identification of genomic biomarkers for anthracycline-induced cardiotoxicity in human iPSC-derived cardiomyocytes: an in vitro repeated exposure toxicity approach for safety assessment. Arch Toxicol. 2016 Nov;90(11):2763-2777.
• [430] The DNA damaging agent VP16 induces the expression of a subset of ligands from the EGF system in bladder cancer cells, whereas none of the four EGF receptors are induced. Mol Cell Biochem. 2004 May;260(1-2):129-35. doi: 10.1023/b:mcbi.0000026063.96267.98.
• [431] Sulindac metabolites induce proteosomal and lysosomal degradation of the epidermal growth factor receptor. Cancer Prev Res (Phila). 2010 Apr;3(4):560-72. doi: 10.1158/1940-6207.CAPR-09-0159. Epub 2010 Mar 23.
• [432] D-Penicillamine targets metastatic melanoma cells with induction of the unfolded protein response (UPR) and Noxa (PMAIP1)-dependent mitochondrial apoptosis. Apoptosis. 2012 Oct;17(10):1079-94.
• [433] Alternatives for the worse: Molecular insights into adverse effects of bisphenol a and substitutes during human adipocyte differentiation. Environ Int. 2021 Nov;156:106730. doi: 10.1016/j.envint.2021.106730. Epub 2021 Jun 27.
• [434] The contact allergen nickel triggers a unique inflammatory and proangiogenic gene expression pattern via activation of NF-kappaB and hypoxia-inducible factor-1alpha. J Immunol. 2007 Mar 1;178(5):3198-207.
• [435] Decrease of plasminogen activator inhibitor-1 may contribute to the anti-invasive action of cannabidiol on human lung cancer cells. Pharm Res. 2010 Oct;27(10):2162-74. doi: 10.1007/s11095-010-0219-2. Epub 2010 Jul 29.
• [436] Unique signatures of stress-induced senescent human astrocytes. Exp Neurol. 2020 Dec;334:113466. doi: 10.1016/j.expneurol.2020.113466. Epub 2020 Sep 17.
• [437] Effect of spironolactone on impaired fibrinolysis of hypertensive patients. Kidney Blood Press Res. 2002;25(4):260-4. doi: 10.1159/000066348.
• [438] Association of cell cycle arrest with anticancer drug-induced epithelial-mesenchymal transition in alveolar epithelial cells. Toxicology. 2019 Aug 1;424:152231. doi: 10.1016/j.tox.2019.06.002. Epub 2019 Jun 4.
• [439] Simvastatin inhibits tissue factor and plasminogen activator inhibitor-1 secretion by peripheral blood mononuclear cells in patients with primary nephrotic syndrome. Eur J Med Res. 2007 May 29;12(5):216-21.
• [440] Polyphenols downregulate PAI-1 gene expression in cultured human coronary artery endothelial cells: molecular contributor to cardiovascular protection. Thromb Res. 2007;121(1):59-65. doi: 10.1016/j.thromres.2007.02.001. Epub 2007 Mar 26.
• [441] Troglitazone reduces plasminogen activator inhibitor-1 expression and secretion in cultured human adipocytes. Diabetologia. 2000 Mar;43(3):377-83. doi: 10.1007/s001250050057.
• [442] Robustness testing and optimization of an adverse outcome pathway on cholestatic liver injury. Arch Toxicol. 2020 Apr;94(4):1151-1172. doi: 10.1007/s00204-020-02691-9. Epub 2020 Mar 10.
• [443] Arsenic trioxide induces different gene expression profiles of genes related to growth and apoptosis in glioma cells dependent on the p53 status. Mol Biol Rep. 2008 Sep;35(3):421-9.
• [444] Investigation of in vitro odonto/osteogenic capacity of cannabidiol on human dental pulp cell. J Dent. 2021 Jun;109:103673. doi: 10.1016/j.jdent.2021.103673. Epub 2021 Apr 16.
• [445] SNHG3 cooperates with ELAVL2 to modulate cell apoptosis and extracellular matrix accumulation by stabilizing SNAI2 in human trabecular meshwork cells under oxidative stress. Environ Toxicol. 2021 Jun;36(6):1070-1079. doi: 10.1002/tox.23106. Epub 2021 Feb 1.
• [446] Effect of spironolactone on plasma brain natriuretic peptide and left ventricular remodeling in patients with congestive heart failure. J Am Coll Cardiol. 2001 Apr;37(5):1228-33. doi: 10.1016/s0735-1097(01)01116-0.
• [447] A systems biology strategy reveals biological pathways and plasma biomarker candidates for potentially toxic statin-induced changes in muscle. PLoS One. 2006 Dec 20;1(1):e97. doi: 10.1371/journal.pone.0000097.
• [448] Suppression of insulin-like growth factor signalling pathway and collagen expression in keloid-derived fibroblasts by quercetin: its therapeutic potential use in the treatment and/or prevention of keloids. Br J Dermatol. 2003 Mar;148(3):544-52. doi: 10.1046/j.1365-2133.2003.05174.x.
• [449] Evaluation of early biomarkers of muscle anabolic response to testosterone. J Cachexia Sarcopenia Muscle. 2011 Mar;2(1):45-56. doi: 10.1007/s13539-011-0021-y. Epub 2011 Feb 26.
• [450] Modelling cardiac fibrosis using three-dimensional cardiac microtissues derived from human embryonic stem cells. J Biol Eng. 2019 Feb 13;13:15. doi: 10.1186/s13036-019-0139-6. eCollection 2019.
• [451] Haloperidol changes mRNA expression of a QKI splice variant in human astrocytoma cells. BMC Pharmacol. 2009 Mar 31;9:6. doi: 10.1186/1471-2210-9-6.
• [452] Long-term estrogen exposure promotes carcinogen bioactivation, induces persistent changes in gene expression, and enhances the tumorigenicity of MCF-7 human breast cancer cells. Toxicol Appl Pharmacol. 2009 Nov 1;240(3):355-66.
• [453] Gene expression profiling of breast cancer cells in response to gemcitabine: NF-kappaB pathway activation as a potential mechanism of resistance. Breast Cancer Res Treat. 2007 Apr;102(2):157-72.
• [454] Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma. Oncotarget. 2014 May 15;5(9):2355-71.
• [455] Benzo[a]pyrene-induced changes in microRNA-mRNA networks. Chem Res Toxicol. 2012 Apr 16;25(4):838-49.
• [456] Transcriptome profile analysis of saturated aliphatic aldehydes reveals carbon number-specific molecules involved in pulmonary toxicity. Chem Res Toxicol. 2014 Aug 18;27(8):1362-70.
• [457] Evaluation of a human iPSC-derived BBB model for repeated dose toxicity testing with cyclosporine A as model compound. Toxicol In Vitro. 2021 Jun;73:105112. doi: 10.1016/j.tiv.2021.105112. Epub 2021 Feb 22.
• [458] The impact of luteal phase support on gene expression of extracellular matrix protein and adhesion molecules in the human endometrium during the window of implantation following controlled ovarian stimulation with a GnRH antagonist protocol. Fertil Steril. 2010 Nov;94(6):2264-71. doi: 10.1016/j.fertnstert.2010.01.068. Epub 2010 Mar 12.
• [459] Primary Human Hepatocyte Spheroids as Tools to Study the Hepatotoxic Potential of Non-Pharmaceutical Chemicals. Int J Mol Sci. 2021 Oct 12;22(20):11005. doi: 10.3390/ijms222011005.
• [460] Glucosamine decreases expression of anabolic and catabolic genes in human osteoarthritic cartilage explants. Osteoarthritis Cartilage. 2006 Mar;14(3):250-7. doi: 10.1016/j.joca.2005.10.001. Epub 2005 Nov 18.
• [461] Gene expression signatures after ethanol exposure in differentiating embryoid bodies. Toxicol In Vitro. 2018 Feb;46:66-76.
• [462] The G Protein-Coupled Estrogen Receptor Agonist G-1 Inhibits Nuclear Estrogen Receptor Activity and Stimulates Novel Phosphoproteomic Signatures. Toxicol Sci. 2016 Jun;151(2):434-46. doi: 10.1093/toxsci/kfw057. Epub 2016 Mar 29.
• [463] Characterization of DNA reactive and non-DNA reactive anticancer drugs by gene expression profiling. Mutat Res. 2007 Jun 1;619(1-2):16-29. doi: 10.1016/j.mrfmmm.2006.12.007. Epub 2007 Feb 8.
• [464] Steroid and xenobiotic receptor-mediated effects of bisphenol A on human osteoblasts. Life Sci. 2016 Jun 15;155:29-35.
• [465] PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies. Nature. 2014 Oct 9;514(7521):247-51.
• [466] Ouabain, a cardiac glycoside, inhibits the Fanconi anemia/BRCA pathway activated by DNA interstrand cross-linking agents. PLoS One. 2013 Oct 4;8(10):e75905. doi: 10.1371/journal.pone.0075905. eCollection 2013.
• [467] Bisphenol A Exposure Changes the Transcriptomic and Proteomic Dynamics of Human Retinoblastoma Y79 Cells. Genes (Basel). 2021 Feb 11;12(2):264. doi: 10.3390/genes12020264.
• [468] Oxidative stress-induced epigenetic changes associated with malignant transformation of human kidney epithelial cells. Oncotarget. 2017 Feb 14;8(7):11127-11143. doi: 10.18632/oncotarget.12091.
• [469] Global effects of inorganic arsenic on gene expression profile in human macrophages. Mol Immunol. 2009 Feb;46(4):649-56.
• [470] The Bromodomain Inhibitor JQ1 and the Histone Deacetylase Inhibitor Panobinostat Synergistically Reduce N-Myc Expression and Induce Anticancer Effects. Clin Cancer Res. 2016 May 15;22(10):2534-44. doi: 10.1158/1078-0432.CCR-15-1666. Epub 2016 Jan 5.
• [471] Gene expression profile of colon cancer cell lines treated with SN-38. Chemotherapy. 2010;56(1):17-25. doi: 10.1159/000287353. Epub 2010 Feb 24.
• [472] Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells. Nat Commun. 2018 Aug 9;9(1):3069. doi: 10.1038/s41467-018-05402-2.
• [473] Drug-induced activation of SREBP-controlled lipogenic gene expression in CNS-related cell lines: marked differences between various antipsychotic drugs. BMC Neurosci. 2006 Oct 20;7:69.
• [474] Multi-parameter in vitro toxicity testing of crizotinib, sunitinib, erlotinib, and nilotinib in human cardiomyocytes. Toxicol Appl Pharmacol. 2013 Oct 1;272(1):245-55.
• [475] Expression profile analysis of human peripheral blood mononuclear cells in response to aspirin. Arch Immunol Ther Exp (Warsz). 2005 Mar-Apr;53(2):151-8.