Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMJ46CB)

Drug Name
Buthionine sulfoximine Drug Info
Synonyms AC1MS6SH
Indication
Disease Entry ICD 11 Status REF
Malaria 1F40-1F45 Investigative [1]
Solid tumour/cancer 2A00-2F9Z Investigative [1]
Cross-matching ID
PubChem CID
21157
ChEBI ID
CHEMBL1256575
CAS Number
CAS 5072-26-4
TTD Drug ID
DMJ46CB

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Investigative Drug(s)
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Glutamate--cysteine ligase modifier (GCLM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
N-Formylmethionine DM7GBDX Discovery agent N.A. Investigative [11]
Cystamine DMS5DHY Discovery agent N.A. Investigative [12]
Drug(s) Affected By Methylated-DNA--protein-cysteine methyltransferase (MGMT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [13]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [14]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [15]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [16]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [17]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [18]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [19]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [20]
Dacarbazine DMNPZL4 Adenocarcinoma 2D40 Approved [21]
Topotecan DMP6G8T Central nervous system neoplasm Approved [22]
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Drug(s) Affected By Transcription factor Jun (JUN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [23]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [24]
Fructose DM43AN2 Vomiting MD90 Approved [25]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [26]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [27]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [28]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [29]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [30]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [31]
Methotrexate DM2TEOL Anterior urethra cancer Approved [32]
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Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [33]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [34]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [35]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [36]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [27]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [37]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [38]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [39]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [40]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [38]
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Drug(s) Affected By CD59 glycoprotein (CD59)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [41]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [42]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [43]
Quercetin DM3NC4M Obesity 5B81 Approved [44]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [45]
Testosterone DM7HUNW Hot flushes GA30 Approved [46]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [46]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [16]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [47]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [18]
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Drug(s) Affected By Aryl hydrocarbon receptor nuclear translocator (ARNT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [3]
Methotrexate DM2TEOL Anterior urethra cancer Approved [48]
Quercetin DM3NC4M Obesity 5B81 Approved [49]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [50]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [51]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [47]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [52]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [53]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [54]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [55]
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Drug(s) Affected By Alpha-synuclein (SNCA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [56]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [57]
Testosterone enanthate DMB6871 N. A. N. A. Approved [58]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [59]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [18]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [60]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [61]
Bortezomib DMNO38U Leukemia Approved [62]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [63]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [64]
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Drug(s) Affected By Mitogen-activated protein kinase 9 (MAPK9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [26]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [65]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [31]
Methotrexate DM2TEOL Anterior urethra cancer Approved [66]
Quercetin DM3NC4M Obesity 5B81 Approved [67]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [45]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [31]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [68]
Sorbitol DMAN0DE Constipation DD91.1 Approved [69]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [16]
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Drug(s) Affected By Ataxin-1 (ATXN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [70]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [30]
Selenium DM25CGV N. A. N. A. Approved [71]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [72]
Methotrexate DM2TEOL Anterior urethra cancer Approved [48]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [56]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [73]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [74]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [74]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [74]
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Drug(s) Affected By Sestrin-2 (SESN2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [75]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [39]
Methotrexate DM2TEOL Anterior urethra cancer Approved [76]
Quercetin DM3NC4M Obesity 5B81 Approved [44]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [77]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [78]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [79]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [78]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [80]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [75]
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Drug(s) Affected By Selenoprotein W (SELENOW)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [10]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [81]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [79]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [82]
Motexafin gadolinium DMEJKRF Brain cancer 2A00 Approved [79]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [61]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [83]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [84]
Arsenic DMTL2Y1 N. A. N. A. Approved [85]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [55]
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Drug(s) Affected By Transcription factor Sp3 (SP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [86]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [86]
Plicamycin DM7C8YV Hypercalcaemia 5B91.0 Approved [87]
Leflunomide DMR8ONJ Arthritis FA20 Approved [88]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [89]
Promegestone DMK4S8I Gynecological disease GA6Z Approved [90]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [91]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [92]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [93]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [55]
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Drug(s) Affected By Mitogen-activated protein kinase 14 (MAPK14)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [94]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [95]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [96]
Methotrexate DM2TEOL Anterior urethra cancer Approved [97]
Quercetin DM3NC4M Obesity 5B81 Approved [98]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [99]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [100]
Ethacrynic acid DM60QMR Edema MG29 Approved [101]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [102]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [103]
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Drug(s) Affected By Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [104]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [105]
Methotrexate DM2TEOL Anterior urethra cancer Approved [106]
Quercetin DM3NC4M Obesity 5B81 Approved [44]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [107]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [108]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [109]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [110]
Trovafloxacin DM6AN32 Acute gonococcal cervicitis Approved [111]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [112]
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Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [96]
Selenium DM25CGV N. A. N. A. Approved [113]
Methotrexate DM2TEOL Anterior urethra cancer Approved [114]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [115]
Epinephrine DM3KJBC Acute asthma CA23 Approved [116]
Quercetin DM3NC4M Obesity 5B81 Approved [117]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [118]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [119]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [120]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [121]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Glutamate--cysteine ligase modifier (GCLM) TTNFESW GSH0_HUMAN Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Alpha-synuclein (SNCA) OTPWC1MR SYUA_HUMAN Gene/Protein Processing [2]
Aryl hydrocarbon receptor nuclear translocator (ARNT) OTMSIEZY ARNT_HUMAN Gene/Protein Processing [3]
Ataxin-1 (ATXN1) OTQF0HNR ATX1_HUMAN Protein Interaction/Cellular Processes [4]
CD59 glycoprotein (CD59) OTSUMQDH CD59_HUMAN Gene/Protein Processing [5]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Protein Interaction/Cellular Processes [6]
Methylated-DNA--protein-cysteine methyltransferase (MGMT) OT40A9WH MGMT_HUMAN Gene/Protein Processing [7]
Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) OTUYHB84 MLP3B_HUMAN Gene/Protein Processing [8]
Mitogen-activated protein kinase 14 (MAPK14) OT5TCO3O MK14_HUMAN Post-Translational Modifications [9]
Mitogen-activated protein kinase 9 (MAPK9) OTCEVJ9E MK09_HUMAN Post-Translational Modifications [9]
Selenoprotein W (SELENOW) OTVSKPAN SELW_HUMAN Gene/Protein Processing [10]

References

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45 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
46 Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
47 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
48 Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
49 Single and concerted effects of benzo[a]pyrene and flavonoids on the AhR and Nrf2-pathway in the human colon carcinoma cell line Caco-2. Toxicol In Vitro. 2011 Apr;25(3):671-83.
50 Omeprazole inhibits pancreatic cancer cell invasion through a nongenomic aryl hydrocarbon receptor pathway. Chem Res Toxicol. 2015 May 18;28(5):907-18.
51 Ligand-independent activation of AhR by hydroquinone mediates benzene-induced hematopoietic toxicity. Chem Biol Interact. 2022 Mar 1;355:109845. doi: 10.1016/j.cbi.2022.109845. Epub 2022 Feb 4.
52 Drug-induced endoplasmic reticulum and oxidative stress responses independently sensitize toward TNF-mediated hepatotoxicity. Toxicol Sci. 2014 Jul;140(1):144-59. doi: 10.1093/toxsci/kfu072. Epub 2014 Apr 20.
53 A fine-needle aspirate-based vulnerability assay identifies polo-like kinase 1 as a mediator of gemcitabine resistance in pancreatic cancer. Mol Cancer Ther. 2010 Feb;9(2):311-8. doi: 10.1158/1535-7163.MCT-09-0693. Epub 2010 Jan 26.
54 17-Estradiol Activates HSF1 via MAPK Signaling in ER-Positive Breast Cancer Cells. Cancers (Basel). 2019 Oct 11;11(10):1533. doi: 10.3390/cancers11101533.
55 Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
56 Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
57 Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
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