Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM2LJFZ)

Drug Name
4-hydroxy-2-nonenal Drug Info
Synonyms
4-Hydroxynonenal; 4-Hydroxy-2-nonenal; 4-hydroxynon-2-enal; trans-4-Hydroxy-2-nonenal; 4-Hydroxy-2,3-nonenal; 4-HNE; 75899-68-2; 4-hydroxy-2E-nonenal; (E)-4-hydroxynon-2-enal; CCRIS 9028; CCRIS 1781; 29343-52-0; 128946-65-6; 2-NONENAL, 4-HYDROXY-; HNE; (E)-4-hydroxy-2-nonenal; (2E)-4-hydroxynon-2-enal; (2E)-4-Hydroxy-2-nonenal; CHEMBL454280; CHEBI:58968; C9H16O2; (+/-)4-HYDROXYNON-2-ENAL; NCGC00161254-02; 4-hydroxynonen-2-al; CHEBI:32585; CCRIS 6927; 4 hydroxynonenal; (E)-4-Hydroxynonenal; AC1Q2VOQ; 4HNE; SCHEMBL3920; AC1Q6PP5; AC1NR22M
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
5283344
ChEBI ID
CHEMBL58968
CAS Number
CAS 75899-68-2
TTD Drug ID
DM2LJFZ
INTEDE Drug ID
DR2062

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Patented Agent(s)
Investigative Drug(s)
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Inhibitor of nuclear factor kappa-B kinase (IKK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dihydrothieno [2,3-e]indazole derivative 1 DMUJ3XK N. A. N. A. Patented [10]
Dihydrothieno [2,3-e]indazole derivative 4 DMR4LPO N. A. N. A. Patented [10]
Dihydrothieno [2,3-e]indazole derivative 3 DM85VQR N. A. N. A. Patented [10]
Dihydrothieno [2,3-e]indazole derivative 2 DM0D3HU N. A. N. A. Patented [10]
PMID23099093C17d DMWS7O9 Discovery agent N.A. Investigative [11]
Arsenite DMBCO4Q Discovery agent N.A. Investigative [12]
5-Bromo-6-methoxy-9H-beta-carboline DM157OQ Discovery agent N.A. Investigative [13]
MRT67307 DMYRCHG Discovery agent N.A. Investigative [14]
PS-1145 DMVUMWZ Multiple myeloma 2A83 Investigative [15]
BMS-345541 DM7D519 Arthritis FA20 Investigative [16]
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Drug(s) Metabolized By NADPH:quinone reductase (CRYZ)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [17]
1,2-NAPHTHOQUINONE DMYXELH Discovery agent N.A. Investigative [18]
Hexylacrolein DMBC8KM N. A. N. A. Investigative [3]
Acetyl ethylene DMUH4N7 N. A. N. A. Investigative [3]
J-009747 DMQSB6N N. A. N. A. Investigative [3]
Drug(s) Affected By Phosphatidylinositol 3-kinase regulatory subunit beta (PIK3R2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [4]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [19]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [20]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [22]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [24]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [25]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [26]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [27]
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Drug(s) Affected By Peripheral plasma membrane protein CASK (CASK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [4]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [19]
Testosterone DM7HUNW Hot flushes GA30 Approved [28]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [29]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [31]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [32]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [33]
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Drug(s) Affected By Cyclin-G-associated kinase (GAK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Baricitinib DM4ONW5 Rheumatoid arthritis FA20 Approved [34]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [19]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [20]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Arsenic DMTL2Y1 N. A. N. A. Approved [35]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [36]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [37]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [38]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [39]
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Drug(s) Affected By Transcription intermediary factor 1-alpha (TRIM24)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [37]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [41]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [29]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [42]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [43]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [44]
Arsenic DMTL2Y1 N. A. N. A. Approved [35]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [45]
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Drug(s) Affected By Linker for activation of T-cells family member 1 (LAT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [46]
Testosterone DM7HUNW Hot flushes GA30 Approved [28]
Leflunomide DMR8ONJ Arthritis FA20 Approved [47]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [24]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [44]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [48]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [49]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [38]
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Drug(s) Affected By Protein sprouty homolog 2 (SPRY2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [39]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [4]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [50]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [29]
Leflunomide DMR8ONJ Arthritis FA20 Approved [47]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [42]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [51]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [24]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [44]
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Drug(s) Affected By 5-hydroxymethyl-dUMP N-hydrolase (DNPH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [4]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [20]
Testosterone enanthate DMB6871 N. A. N. A. Approved [52]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [42]
Heroin diacetylmorphine DMDBWHY Neurological disorder 6B60 Approved [53]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Ethanol DMDRQZU Chronic pain MG30 Approved [54]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [24]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [55]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [44]
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Drug(s) Affected By Cyclin-T1 (CCNT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [4]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [56]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [20]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [42]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [57]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [58]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [36]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [59]
Urethane DM7NSI0 N. A. N. A. Phase 4 [60]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [59]
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Drug(s) Affected By Nibrin (NBN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [41]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [61]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [62]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [63]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Pentamidine DMHZJCG African trypanosomiasis 1F51 Approved [64]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [44]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [65]
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Drug(s) Affected By Transcriptional adapter 3 (TADA3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [37]
Quercetin DM3NC4M Obesity 5B81 Approved [66]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [41]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [24]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [36]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [37]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [38]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [67]
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Drug(s) Affected By PR domain zinc finger protein 1 (PRDM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [68]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Panobinostat DM58WKG Chronic graft versus host disease Approved [70]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [71]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [72]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [73]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [73]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [73]
Ibrutinib DMHZCPO Mantle cell lymphoma 2A85.5 Approved [74]
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Drug(s) Affected By Cyclin-K (CCNK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [75]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [20]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [44]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [76]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [59]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [38]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [77]
Geldanamycin DMS7TC5 Kidney cancer 2C90.0 Discontinued in Phase 2 [78]
NS398 DMINUWH Endometriosis GA10 Terminated [79]
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Drug(s) Affected By DNA fragmentation factor subunit beta (DFFB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [80]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [41]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [81]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [62]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [71]
Testosterone DM7HUNW Hot flushes GA30 Approved [82]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [82]
Leflunomide DMR8ONJ Arthritis FA20 Approved [47]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [20]
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Drug(s) Affected By Elongator complex protein 1 (ELP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [37]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [81]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [20]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Motexafin gadolinium DMEJKRF Brain cancer 2A00 Approved [81]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [57]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [44]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [45]
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Drug(s) Affected By Neuroendocrine secretory protein 55 (GNAS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [4]
Selenium DM25CGV N. A. N. A. Approved [37]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Panobinostat DM58WKG Chronic graft versus host disease Approved [70]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [83]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [84]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Clozapine DMFC71L Schizophrenia 6A20 Approved [85]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [57]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [25]
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Drug(s) Affected By Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [86]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [87]
Menthol DMG2KW7 Back pain ME84.Z Approved [88]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [44]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [89]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [32]
Hydroxychloroquine DMSIVND Chronic renal failure GB61.Z Approved [90]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [91]
Arsenic DMTL2Y1 N. A. N. A. Approved [92]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [36]
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Drug(s) Affected By Protein c-Fos (FOS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [19]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [93]
Verapamil DMA7PEW Angina pectoris BA40 Approved [94]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [95]
Acebutolol DM0TI4U Hypertension BA00-BA04 Approved [94]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [96]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [4]
Methotrexate DM2TEOL Anterior urethra cancer Approved [97]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [98]
Quercetin DM3NC4M Obesity 5B81 Approved [99]
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Drug(s) Affected By Myc proto-oncogene protein (MYC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [100]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [95]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [96]
Gefitinib DM15F0X Colon adenocarcinoma Approved [101]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [46]
Selenium DM25CGV N. A. N. A. Approved [102]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [103]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [104]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [105]
Methotrexate DM2TEOL Anterior urethra cancer Approved [106]
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Drug(s) Affected By Proenkephalin-B (PDYN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [4]
Panobinostat DM58WKG Chronic graft versus host disease Approved [70]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [42]
Heroin diacetylmorphine DMDBWHY Neurological disorder 6B60 Approved [53]
Ethanol DMDRQZU Chronic pain MG30 Approved [107]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [57]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [108]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [108]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [109]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [110]
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Drug(s) Affected By Receptor tyrosine-protein kinase erbB-2 (ERBB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Trastuzumab DMZQOUX Breast cancer 2C60-2C65 Approved [111]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [112]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [113]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [96]
Gefitinib DM15F0X Colon adenocarcinoma Approved [114]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [4]
Selenium DM25CGV N. A. N. A. Approved [37]
Methotrexate DM2TEOL Anterior urethra cancer Approved [115]
Quercetin DM3NC4M Obesity 5B81 Approved [116]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
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Drug(s) Affected By Calpain small subunit 1 (CAPNS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [4]
Selenium DM25CGV N. A. N. A. Approved [37]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [117]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [118]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [24]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [55]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [36]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [119]
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Drug(s) Affected By Amyloid-beta precursor protein (APP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [4]
Selenium DM25CGV N. A. N. A. Approved [37]
Methotrexate DM2TEOL Anterior urethra cancer Approved [106]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [120]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [68]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [121]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [122]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [123]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [19]
Aluminium DM6ECN9 Hyperhidrosis EE00 Approved [124]
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Drug(s) Affected By Transcription factor Jun (JUN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [125]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [126]
Fructose DM43AN2 Vomiting MD90 Approved [111]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [127]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [128]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [95]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [129]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [130]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [131]
Methotrexate DM2TEOL Anterior urethra cancer Approved [132]
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Drug(s) Affected By Tyrosine-protein kinase Lck (LCK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [39]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [133]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [134]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [61]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [118]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [135]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [136]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [137]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [138]
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Drug(s) Affected By Tyrosine-protein kinase Lyn (LYN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [39]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [61]
Panobinostat DM58WKG Chronic graft versus host disease Approved [70]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [118]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [42]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [140]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Synaptophysin (SYP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [4]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [141]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [83]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Ethanol DMDRQZU Chronic pain MG30 Approved [142]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [141]
Abacavir DMMN36E Human immunodeficiency virus infection 1C62 Approved [143]
Methamphetamine DMPM4SK Anxiety Approved [144]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [32]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [26]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-3 (IL3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [106]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [145]
Ethanol DMDRQZU Chronic pain MG30 Approved [145]
Menthol DMG2KW7 Back pain ME84.Z Approved [88]
Betamethasone Valerate DMMIAXO Dermatological disease DA24.Y Approved [146]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [147]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [110]
Tacrolimus DMZ7XNQ Graft-versus-host disease 4B24 Approved [146]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [111]
Famotidine DMRL3AB Gastric ulcer DA60 Approved [111]
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Drug(s) Affected By Interleukin-6 receptor subunit alpha (IL6R)
Drug Name Drug ID Indication ICD 11 Highest Status REF
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [148]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [149]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [41]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [150]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Testosterone enanthate DMB6871 N. A. N. A. Approved [52]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [151]
Emetine DMCT2YF Hepatitis virus infection 1E50-1E51 Approved [152]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [153]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [154]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Neuromedin-B (NMB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [155]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [156]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [155]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [157]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [20]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Folic Acid DMEMBJC Colorectal carcinoma Approved [158]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [24]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [155]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-C motif chemokine 3 (CCL3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [159]
Methotrexate DM2TEOL Anterior urethra cancer Approved [106]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [160]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [161]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [162]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [163]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [164]
Betamethasone DMAHJEF Acute adrenal insufficiency Approved [152]
Emetine DMCT2YF Hepatitis virus infection 1E50-1E51 Approved [152]
Nelfinavir mesylate DMFX6G8 N. A. N. A. Approved [159]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Myb-related protein B (MYBL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [4]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [165]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [139]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [166]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [157]
Testosterone DM7HUNW Hot flushes GA30 Approved [82]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [139]
Exemestane DM9HPW3 Hormonally-responsive breast cancer 2C60-2C65 Approved [167]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [168]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear receptor subfamily 2 group F member 6 (NR2F6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [169]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [4]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [19]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [24]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [44]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [25]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [45]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [169]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [25]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ezrin (EZR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [85]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [170]
Selenium DM25CGV N. A. N. A. Approved [37]
Methotrexate DM2TEOL Anterior urethra cancer Approved [115]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [50]
Panobinostat DM58WKG Chronic graft versus host disease Approved [70]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [171]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [172]
Haloperidol DM96SE0 Delirium Approved [85]
Leflunomide DMR8ONJ Arthritis FA20 Approved [47]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By SH2/SH3 adapter protein NCK1 (NCK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [106]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [133]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [70]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [140]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [173]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [174]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [175]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [176]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-7 receptor subunit alpha (IL7R)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [177]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [118]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [72]
Testosterone DM7HUNW Hot flushes GA30 Approved [28]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [29]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [178]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [22]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [24]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [179]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [180]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor JunD (JUND)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [128]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [95]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [4]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [181]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [182]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [81]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [183]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [46]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [172]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Calpain-2 catalytic subunit (CAPN2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [184]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [4]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [41]
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [185]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [186]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [118]
Testosterone DM7HUNW Hot flushes GA30 Approved [82]
Glibenclamide DM8JXPZ Diabetic complication 5A2Y Approved [185]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [82]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By General transcription and DNA repair factor IIH helicase subunit XPD (ERCC2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [187]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [41]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [171]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [20]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Menthol DMG2KW7 Back pain ME84.Z Approved [88]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [48]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [27]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [36]
Arsenic DMTL2Y1 N. A. N. A. Approved [188]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glutathione peroxidase 2 (GPX2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [189]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [190]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [191]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [149]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [43]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [192]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [193]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [183]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [71]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cadherin-2 (CDH2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [4]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [194]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [141]
Panobinostat DM58WKG Chronic graft versus host disease Approved [70]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [195]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [196]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [197]
Testosterone DM7HUNW Hot flushes GA30 Approved [198]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [199]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ETS domain-containing protein Elk-1 (ELK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [112]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [4]
Quercetin DM3NC4M Obesity 5B81 Approved [200]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [201]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [202]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [203]
Testosterone enanthate DMB6871 N. A. N. A. Approved [52]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [204]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [24]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [111]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [205]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [206]
Methotrexate DM2TEOL Anterior urethra cancer Approved [207]
Quercetin DM3NC4M Obesity 5B81 Approved [208]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [209]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [81]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [19]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [210]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [211]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [212]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [172]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [95]
Gefitinib DM15F0X Colon adenocarcinoma Approved [213]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [4]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [214]
Methotrexate DM2TEOL Anterior urethra cancer Approved [215]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [216]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [217]
Quercetin DM3NC4M Obesity 5B81 Approved [208]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cadherin-3 (CDH3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [4]
Selenium DM25CGV N. A. N. A. Approved [37]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [194]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Panobinostat DM58WKG Chronic graft versus host disease Approved [70]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [157]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [194]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [218]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [84]
Folic Acid DMEMBJC Colorectal carcinoma Approved [219]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nucleoside diphosphate kinase B (NME2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [220]
Testosterone DM7HUNW Hot flushes GA30 Approved [28]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [221]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Capsaicin DMGMF6V Back pain ME84.Z Approved [222]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [223]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [220]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [55]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [224]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [225]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ferrochelatase, mitochondrial (FECH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [4]
Selenium DM25CGV N. A. N. A. Approved [37]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [226]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [73]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [73]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [227]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [42]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [73]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [140]
Benzoic Acid DMKB9FI Alopecia areata ED70.2 Approved [227]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Trans-acting T-cell-specific transcription factor GATA-3 (GATA3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [170]
Methotrexate DM2TEOL Anterior urethra cancer Approved [106]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [194]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [228]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [229]
Panobinostat DM58WKG Chronic graft versus host disease Approved [70]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [230]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [218]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [231]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Adenomatous polyposis coli protein (APC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [4]
Selenium DM25CGV N. A. N. A. Approved [37]
Quercetin DM3NC4M Obesity 5B81 Approved [208]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [133]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [157]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [232]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [233]
Folic Acid DMEMBJC Colorectal carcinoma Approved [234]
Menthol DMG2KW7 Back pain ME84.Z Approved [88]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [31]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA polymerase delta catalytic subunit (POLD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [235]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [4]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [68]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [236]
Testosterone DM7HUNW Hot flushes GA30 Approved [82]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [82]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [20]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Arsenic DMTL2Y1 N. A. N. A. Approved [35]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [36]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA excision repair protein ERCC-5 (ERCC5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [181]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [181]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [70]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [24]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [44]
Arsenic DMTL2Y1 N. A. N. A. Approved [237]
Ximelegatran DMU8ANS Myocardial infarction BA41-BA43 Approved [238]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [239]
Seocalcitol DMKL9QO Rickets 5B57 Phase 3 [240]
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Drug(s) Affected By M-phase inducer phosphatase 1 (CDC25A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [235]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [4]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [241]
Methotrexate DM2TEOL Anterior urethra cancer Approved [242]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [243]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [68]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [41]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [244]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [210]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [245]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Adenosine receptor A1 (ADORA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [169]
Gefitinib DM15F0X Colon adenocarcinoma Approved [213]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [4]
Testosterone DM7HUNW Hot flushes GA30 Approved [82]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [82]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Adenosine DMM2NSK Paroxysmal supraventricular tachycardia BC81.Z Approved [246]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [55]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [110]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [58]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor HIVEP2 (HIVEP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [29]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Testosterone enanthate DMB6871 N. A. N. A. Approved [52]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [247]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [248]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [249]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [44]
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Drug(s) Affected By DNA replication licensing factor MCM4 (MCM4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [235]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [4]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [250]
Quercetin DM3NC4M Obesity 5B81 Approved [208]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [68]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [19]
Testosterone DM7HUNW Hot flushes GA30 Approved [82]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [82]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [168]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Catenin beta-1 (CTNNB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [127]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [4]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [251]
Quercetin DM3NC4M Obesity 5B81 Approved [252]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [253]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [254]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [255]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [256]
Testosterone DM7HUNW Hot flushes GA30 Approved [198]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [257]
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Drug(s) Affected By Merlin (NF2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [4]
Selenium DM25CGV N. A. N. A. Approved [37]
Methotrexate DM2TEOL Anterior urethra cancer Approved [207]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [258]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [259]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [57]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [44]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [32]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [170]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serpin B5 (SERPINB5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [190]
Methotrexate DM2TEOL Anterior urethra cancer Approved [115]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [260]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [218]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [73]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
2-deoxyglucose DMIAHVU Solid tumour/cancer 2A00-2F9Z Approved [261]
Adefovir Dipivoxil DMMAWY1 Hepatitis B virus infection 1E51.0 Approved [73]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [262]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [263]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Homeobox protein cut-like 1 (CUX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [4]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [20]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [48]
Arsenic DMTL2Y1 N. A. N. A. Approved [35]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [45]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [59]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [264]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [265]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [37]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-6 receptor subunit beta (IL6ST)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [266]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [267]
Selenium DM25CGV N. A. N. A. Approved [37]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [149]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [268]
Lenalidomide DM6Q7U4 Adult T-cell leukemia/lymphoma Approved [269]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [269]
Testosterone DM7HUNW Hot flushes GA30 Approved [82]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA-binding protein inhibitor ID-1 (ID1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [270]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [271]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [4]
Selenium DM25CGV N. A. N. A. Approved [37]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [272]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [273]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [71]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [157]
Leflunomide DMR8ONJ Arthritis FA20 Approved [47]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ETS translocation variant 3 (ETV3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [50]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [274]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [36]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [275]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [38]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [276]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [277]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [77]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [278]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor ETV6 (ETV6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [279]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [44]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [173]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [263]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [45]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [59]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [279]
Permethrin DMZ0Q1G Pediculus capitis infestation 1G00.0 Approved [279]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [280]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Myeloid cell nuclear differentiation antigen (MNDA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [162]
Coprexa DMA0WEK Neurological disorder 6B60 Phase 3 [281]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [282]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [77]
Sulforaphane DMQY3L0 Skin disease EA00-EM0Z Investigative [283]
Drug(s) Affected By Epidermal growth factor receptor substrate 15 (EPS15)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gefitinib DM15F0X Colon adenocarcinoma Approved [213]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [284]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [20]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [44]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [233]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [285]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [38]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-12 receptor subunit beta-1 (IL12RB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [286]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [32]
Arsenic DMTL2Y1 N. A. N. A. Approved [35]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [286]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [110]
phorbol 12-myristate 13-acetate DMJWD62 Acute myeloid leukaemia 2A60 Phase 2 [287]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [49]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [288]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [22]
Dimethylallyl Diphosphate DMP5I47 Discovery agent N.A. Investigative [289]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-X-C motif chemokine 5 (CXCL5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [235]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [290]
Panobinostat DM58WKG Chronic graft versus host disease Approved [70]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [171]
Testosterone DM7HUNW Hot flushes GA30 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [42]
Clozapine DMFC71L Schizophrenia 6A20 Approved [291]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [292]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [140]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [293]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Radiation-inducible immediate-early gene IEX-1 (IER3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [294]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [4]
Selenium DM25CGV N. A. N. A. Approved [295]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [68]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [133]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [231]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [61]
Panobinostat DM58WKG Chronic graft versus host disease Approved [70]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [71]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By MARCKS-related protein (MARCKSL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [4]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [41]
Testosterone DM7HUNW Hot flushes GA30 Approved [28]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [292]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [24]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [296]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [45]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [297]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Amphiphysin (AMPH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [4]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Testosterone DM7HUNW Hot flushes GA30 Approved [28]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [42]
Heroin diacetylmorphine DMDBWHY Neurological disorder 6B60 Approved [53]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Ethanol DMDRQZU Chronic pain MG30 Approved [298]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [248]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [299]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dual specificity protein kinase CLK3 (CLK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [77]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [41]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [19]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [118]
Leflunomide DMR8ONJ Arthritis FA20 Approved [47]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [20]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [300]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [296]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [44]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [36]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tuberin (TSC2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [4]
Selenium DM25CGV N. A. N. A. Approved [37]
Methotrexate DM2TEOL Anterior urethra cancer Approved [106]
Quercetin DM3NC4M Obesity 5B81 Approved [116]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [301]
Methamphetamine DMPM4SK Anxiety Approved [302]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [76]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [303]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase inhibitor 1C (CDKN1C)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [170]
Selenium DM25CGV N. A. N. A. Approved [37]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [250]
Quercetin DM3NC4M Obesity 5B81 Approved [116]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [304]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [304]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [71]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [83]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [204]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Rho GDP-dissociation inhibitor 1 (ARHGDIA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [4]
Selenium DM25CGV N. A. N. A. Approved [37]
Etretinate DM2CZFA Keratosis ED56 Approved [220]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [50]
Estrone DM5T6US Acne vulgaris ED80 Approved [305]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [306]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [75]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [42]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Ampicillin DMHWE7P Acute epiglottitis Approved [40]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ephrin-A4 (EFNA4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [170]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [50]
Leflunomide DMR8ONJ Arthritis FA20 Approved [47]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [20]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [44]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [32]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [307]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [36]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Death-associated protein kinase 1 (DAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [4]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [50]
Testosterone DM7HUNW Hot flushes GA30 Approved [82]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [29]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [20]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [84]
Menthol DMG2KW7 Back pain ME84.Z Approved [88]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [308]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [309]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Heat shock-related 70 kDa protein 2 (HSPA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [294]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [170]
Quercetin DM3NC4M Obesity 5B81 Approved [310]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [68]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [161]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [117]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [311]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [312]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [42]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sodium/potassium-transporting ATPase subunit beta-3 (ATP1B3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [313]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [41]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [83]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [248]
Arsenic DMTL2Y1 N. A. N. A. Approved [35]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [26]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [314]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase 4 inhibitor D (CDKN2D)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [4]
Etretinate DM2CZFA Keratosis ED56 Approved [315]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [316]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [317]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [318]
Testosterone DM7HUNW Hot flushes GA30 Approved [82]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [82]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [20]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [319]
Menthol DMG2KW7 Back pain ME84.Z Approved [88]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PPP1CA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [313]
Selenium DM25CGV N. A. N. A. Approved [37]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [117]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [24]
Amiloride DMRTSGP Congestive heart failure BD10 Approved [320]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [321]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [36]
Aminoglutethimide DMWFHMZ Cushing disease 5A70 Approved [322]
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Drug(s) Affected By Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (GNB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [4]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [323]
Testosterone enanthate DMB6871 N. A. N. A. Approved [52]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [324]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [321]
Arsenic DMTL2Y1 N. A. N. A. Approved [35]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [36]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [59]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (GNB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gefitinib DM15F0X Colon adenocarcinoma Approved [213]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [4]
Selenium DM25CGV N. A. N. A. Approved [37]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [41]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [118]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [42]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [325]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [26]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [326]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Casein kinase I isoform gamma-2 (CSNK1G2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [4]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Arsenic DMTL2Y1 N. A. N. A. Approved [35]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [36]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [37]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [38]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [276]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [39]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Transcription initiation factor IIB (GTF2B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [4]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [181]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [157]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [24]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [44]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [45]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [36]
Urethane DM7NSI0 N. A. N. A. Phase 4 [60]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [285]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor E2F1 (E2F1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [327]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [294]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [328]
Gefitinib DM15F0X Colon adenocarcinoma Approved [329]
Selenium DM25CGV N. A. N. A. Approved [37]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [241]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [330]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [250]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [68]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor Sp2 (SP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [319]
Folic Acid DMEMBJC Colorectal carcinoma Approved [331]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [36]
Urethane DM7NSI0 N. A. N. A. Phase 4 [60]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [38]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [77]
⏷ Show the Full List of 6 Drug(s)
Drug(s) Affected By Dystonin (DST)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [39]
Quercetin DM3NC4M Obesity 5B81 Approved [77]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [133]
Panobinostat DM58WKG Chronic graft versus host disease Approved [70]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [171]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [20]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [232]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Folic Acid DMEMBJC Colorectal carcinoma Approved [331]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor alpha-induced protein 2 (TNFAIP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [37]
Methotrexate DM2TEOL Anterior urethra cancer Approved [155]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [133]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [155]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [71]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [332]
Leflunomide DMR8ONJ Arthritis FA20 Approved [47]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tight junction protein ZO-1 (TJP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [333]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [4]
Methotrexate DM2TEOL Anterior urethra cancer Approved [115]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [157]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [233]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Ethanol DMDRQZU Chronic pain MG30 Approved [334]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [335]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [336]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [337]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [338]
Selenium DM25CGV N. A. N. A. Approved [37]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [339]
Methotrexate DM2TEOL Anterior urethra cancer Approved [115]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [340]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [341]
Quercetin DM3NC4M Obesity 5B81 Approved [208]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [160]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein phosphatase 3 catalytic subunit alpha (PPP3CA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [342]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [343]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [29]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Benzatropine DMF7EXL Parkinsonian disorder Approved [85]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [140]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [344]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [45]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Retinoblastoma-like protein 2 (RBL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [4]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [345]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [346]
Leflunomide DMR8ONJ Arthritis FA20 Approved [47]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Testosterone enanthate DMB6871 N. A. N. A. Approved [52]
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [347]
Menthol DMG2KW7 Back pain ME84.Z Approved [88]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [44]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [32]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Epidermal growth factor receptor kinase substrate 8 (EPS8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [170]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [41]
Plicamycin DM7C8YV Hypercalcaemia 5B91.0 Approved [348]
Leflunomide DMR8ONJ Arthritis FA20 Approved [47]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Benzatropine DMF7EXL Parkinsonian disorder Approved [85]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [248]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ral guanine nucleotide dissociation stimulator (RALGDS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [83]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [233]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [22]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [349]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [48]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [45]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [36]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [59]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [350]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [4]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [250]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [41]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [81]
Quinolones DM5GVHU Bacterial infection 1A00-1C4Z Approved [351]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [352]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [311]
Testosterone DM7HUNW Hot flushes GA30 Approved [28]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [73]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcriptional repressor NF-X1 (NFX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [41]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [42]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [45]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [36]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [77]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [77]
Milchsaure DM462BT Pruritus EC90 Investigative [353]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [354]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Tetraspanin-31 (TSPAN31)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [41]
Testosterone DM7HUNW Hot flushes GA30 Approved [82]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [82]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [42]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [108]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [108]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [355]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [59]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [356]
COUMESTROL DM40TBU Discovery agent N.A. Investigative [357]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Rho GTPase-activating protein 5 (ARHGAP5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [207]
Panobinostat DM58WKG Chronic graft versus host disease Approved [70]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [19]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [29]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [42]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [44]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [173]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [32]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [36]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [176]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 5 (MAP2K5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [4]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [41]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [118]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [42]
Hesperidin DMI5DW1 Vascular purpura 3B60 Approved [358]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [25]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [91]
Arsenic DMTL2Y1 N. A. N. A. Approved [35]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [355]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [359]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DnaJ homolog subfamily C member 3 (DNAJC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [41]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [61]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [81]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [284]
Testosterone DM7HUNW Hot flushes GA30 Approved [28]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [29]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [168]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [360]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Methanethiol oxidase (SELENBP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [361]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Estrone DM5T6US Acne vulgaris ED80 Approved [305]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [24]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [248]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [305]
Estriol DMOEM2I Hormone deficiency 5A61.1 Approved [305]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Integrin alpha-7 (ITGA7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [4]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [29]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [259]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [248]
Arsenic DMTL2Y1 N. A. N. A. Approved [362]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [363]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [36]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [299]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor Dp-2 (TFDP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [133]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [61]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [332]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [42]
Menthol DMG2KW7 Back pain ME84.Z Approved [88]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [31]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [249]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [48]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [364]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Src substrate cortactin (CTTN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [365]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [41]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [61]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [73]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [73]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [20]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [73]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fas-activated serine/threonine kinase (FASTK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [304]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [304]
Testosterone DM7HUNW Hot flushes GA30 Approved [28]
Testosterone enanthate DMB6871 N. A. N. A. Approved [52]
Folic Acid DMEMBJC Colorectal carcinoma Approved [331]
Menthol DMG2KW7 Back pain ME84.Z Approved [88]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [24]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [304]
Bortezomib DMNO38U Leukemia Approved [204]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [44]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Endoplasmic reticulum membrane sensor NFE2L1 (NFE2L1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [4]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [181]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [233]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [224]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [366]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [175]
Arsenic DMTL2Y1 N. A. N. A. Approved [367]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [26]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [368]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear factor 1 X-type (NFIX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [4]
Methotrexate DM2TEOL Anterior urethra cancer Approved [207]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [41]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [157]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [20]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [369]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [247]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [370]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [32]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear receptor subfamily 1 group I member 3 (NR1I3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [371]
Quercetin DM3NC4M Obesity 5B81 Approved [372]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [373]
Artemether DM48QOT Malaria 1F40-1F45 Approved [374]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [375]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [183]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [376]
Estrone DM5T6US Acne vulgaris ED80 Approved [377]
Leflunomide DMR8ONJ Arthritis FA20 Approved [378]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nectin-1 (NECTIN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [170]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [50]
Leflunomide DMR8ONJ Arthritis FA20 Approved [47]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [44]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [108]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [108]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [359]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [36]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [379]
3R14S-OCHRATOXIN A DM2KEW6 Discovery agent N.A. Investigative [380]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Receptor tyrosine-protein kinase erbB-4 (ERBB4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [50]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [318]
Testosterone DM7HUNW Hot flushes GA30 Approved [28]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [381]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [70]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [382]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [383]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [44]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [173]
Arsenic DMTL2Y1 N. A. N. A. Approved [35]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Elongin-C (ELOC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [44]
Arsenic DMTL2Y1 N. A. N. A. Approved [35]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [355]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [36]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [59]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [384]
Milchsaure DM462BT Pruritus EC90 Investigative [353]
Okadaic acid DM47CO1 Discovery agent N.A. Investigative [385]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Myosin light chain kinase, smooth muscle (MYLK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [386]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Panobinostat DM58WKG Chronic graft versus host disease Approved [70]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [387]
Testosterone DM7HUNW Hot flushes GA30 Approved [82]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [199]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [82]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [42]
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Drug(s) Affected By Mothers against decapentaplegic homolog 1 (SMAD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [46]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [157]
Leflunomide DMR8ONJ Arthritis FA20 Approved [47]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [22]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [44]
Arsenic DMTL2Y1 N. A. N. A. Approved [388]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [36]
Prednisolone DMQ8FR2 Acute adrenal insufficiency Approved [111]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [389]
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Drug(s) Affected By Intersectin-1 (ITSN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [41]
Testosterone DM7HUNW Hot flushes GA30 Approved [28]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [32]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [390]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [38]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [276]
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Drug(s) Affected By Nuclear factor related to kappa-B-binding protein (NFRKB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [4]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Arsenic DMTL2Y1 N. A. N. A. Approved [35]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [70]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [275]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [288]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [276]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [77]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [77]
QUERCITRIN DM1DH96 Discovery agent N.A. Investigative [391]
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Drug(s) Affected By TRAF family member-associated NF-kappa-B activator (TANK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [4]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [41]
Testosterone DM7HUNW Hot flushes GA30 Approved [28]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [392]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [22]
Menthol DMG2KW7 Back pain ME84.Z Approved [88]
Bortezomib DMNO38U Leukemia Approved [204]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [25]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [393]
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Drug(s) Affected By Neogenin (NEO1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [170]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [41]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [394]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [20]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Ethanol DMDRQZU Chronic pain MG30 Approved [395]
Folic Acid DMEMBJC Colorectal carcinoma Approved [331]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [51]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [24]
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Drug(s) Affected By Bcl2-associated agonist of cell death (BAD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [396]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [397]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [266]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [398]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [399]
Quercetin DM3NC4M Obesity 5B81 Approved [400]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [149]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [401]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [62]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [210]
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Drug(s) Affected By P2X purinoceptor 5 (P2RX5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [50]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [83]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [22]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [32]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [26]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [359]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [36]
Tamibarotene DM3G74J T-cell leukaemia 2A90 Phase 3 [402]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [70]
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Drug(s) Affected By Far upstream element-binding protein 1 (FUBP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [272]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [403]
Leflunomide DMR8ONJ Arthritis FA20 Approved [47]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [20]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [42]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Clozapine DMFC71L Schizophrenia 6A20 Approved [85]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [364]
Arsenic DMTL2Y1 N. A. N. A. Approved [35]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [45]
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Drug(s) Affected By Neuroserpin (SERPINI1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Testosterone DM7HUNW Hot flushes GA30 Approved [82]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [82]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [404]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [22]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [44]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [45]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [405]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Polyadenylate-binding protein-interacting protein 1 (PAIP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [4]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [50]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [406]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [42]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [22]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Gentamicin DMKINJO Bacteremia 1A73 Approved [406]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [44]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [406]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [406]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Leucine-rich repeat protein SHOC-2 (SHOC2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [170]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [232]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [44]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [36]
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Drug(s) Affected By Cocaine esterase (CES2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [407]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [408]
Dextropropoxyphene DM23HCX Pain MG30-MG3Z Approved [409]
Methotrexate DM2TEOL Anterior urethra cancer Approved [207]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Tacrine DM51FY6 Alzheimer disease 8A20 Approved [410]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [411]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Testosterone enanthate DMB6871 N. A. N. A. Approved [52]
Cantharidin DMBP5N3 Molluscum contagiosum infection 1E76 Approved [412]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Aflatoxin B1 aldehyde reductase member 2 (AKR7A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [413]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [44]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [48]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [175]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [414]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [176]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [415]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [416]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Aldo-keto reductase family 1 member C3 (AKR1C3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [36]
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [417]
Diazepam DM08E9O Alcohol withdrawal Approved [418]
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [419]
Desogestrel DM27U4Y Contraception QA21 Approved [419]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [417]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [417]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [420]
Quercetin DM3NC4M Obesity 5B81 Approved [421]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [50]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor protein p73 (TP73)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [422]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [39]
Etretinate DM2CZFA Keratosis ED56 Approved [423]
Quercetin DM3NC4M Obesity 5B81 Approved [66]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [424]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [83]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [87]
Menthol DMG2KW7 Back pain ME84.Z Approved [88]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [425]
Bexarotene DMOBIKY Cutaneous T-cell lymphoma 2B01 Approved [423]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Microphthalmia-associated transcription factor (MITF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [426]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [427]
Quercetin DM3NC4M Obesity 5B81 Approved [428]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [429]
Vemurafenib DM62UG5 Melanoma 2C30 Approved [430]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [29]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [42]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transient receptor potential cation channel subfamily A member 1 (TRPA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [93]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [431]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Capsaicin DMGMF6V Back pain ME84.Z Approved [432]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [51]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [431]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [433]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [59]
phorbol 12-myristate 13-acetate DMJWD62 Acute myeloid leukaemia 2A60 Phase 2 [434]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [356]
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Drug(s) Affected By Ubiquitin-like modifier-activating enzyme ATG7 (ATG7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gefitinib DM15F0X Colon adenocarcinoma Approved [435]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [436]
Quercetin DM3NC4M Obesity 5B81 Approved [437]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [41]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [183]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [438]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [439]
Promethazine DM6I5GR Hyperemesis gravidarum Approved [440]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [183]
Cantharidin DMBP5N3 Molluscum contagiosum infection 1E76 Approved [441]
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Drug(s) Affected By GDH/6PGL endoplasmic bifunctional protein (H6PD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [37]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [442]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [394]
Testosterone DM7HUNW Hot flushes GA30 Approved [443]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [443]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [24]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [31]
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Drug(s) Affected By Mitochondrial uncoupling protein 4 (SLC25A27)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [29]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [70]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [45]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [444]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [359]
Urethane DM7NSI0 N. A. N. A. Phase 4 [60]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [276]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [445]
Milchsaure DM462BT Pruritus EC90 Investigative [353]
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Drug(s) Affected By Metalloproteinase inhibitor 1 (TIMP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Pentoxifylline DMU3DNC Alcoholic hepatitis DB94.1 Approved [111]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [446]
Verapamil DMA7PEW Angina pectoris BA40 Approved [447]
Selenium DM25CGV N. A. N. A. Approved [448]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [447]
Quercetin DM3NC4M Obesity 5B81 Approved [449]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [149]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [133]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [450]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [451]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Collagen alpha-1(I) chain (COL1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [111]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [452]
Diazepam DM08E9O Alcohol withdrawal Approved [453]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [187]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [454]
Methotrexate DM2TEOL Anterior urethra cancer Approved [455]
Ceruletide DM2WE5K Caerulein stimulated gastric and pancreatic secretion 5A4Y Approved [456]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [457]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [458]
Quercetin DM3NC4M Obesity 5B81 Approved [459]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interstitial collagenase (MMP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [235]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [460]
Etretinate DM2CZFA Keratosis ED56 Approved [461]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [462]
Methotrexate DM2TEOL Anterior urethra cancer Approved [115]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [463]
Quercetin DM3NC4M Obesity 5B81 Approved [464]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [465]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [466]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [46]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [467]
Selenium DM25CGV N. A. N. A. Approved [295]
Methotrexate DM2TEOL Anterior urethra cancer Approved [155]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [468]
Epinephrine DM3KJBC Acute asthma CA23 Approved [469]
Quercetin DM3NC4M Obesity 5B81 Approved [470]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [194]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [149]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [471]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [472]
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Drug(s) Affected By Retinoblastoma-associated protein (RB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [473]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [474]
Gefitinib DM15F0X Colon adenocarcinoma Approved [475]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [476]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [4]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [104]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [330]
Methotrexate DM2TEOL Anterior urethra cancer Approved [242]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [477]
Quercetin DM3NC4M Obesity 5B81 Approved [116]
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Drug(s) Affected By Alpha-enolase (ENO1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [478]
Etretinate DM2CZFA Keratosis ED56 Approved [220]
Methotrexate DM2TEOL Anterior urethra cancer Approved [479]
Quercetin DM3NC4M Obesity 5B81 Approved [480]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [149]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [81]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [481]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [312]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [73]
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Drug(s) Affected By Heat shock protein HSP 90-alpha (HSP90AA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [258]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [266]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [169]
Gefitinib DM15F0X Colon adenocarcinoma Approved [482]
Selenium DM25CGV N. A. N. A. Approved [37]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [483]
Quercetin DM3NC4M Obesity 5B81 Approved [310]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [484]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [294]
Gefitinib DM15F0X Colon adenocarcinoma Approved [485]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [486]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [338]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [487]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [488]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [487]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [489]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [490]
Methotrexate DM2TEOL Anterior urethra cancer Approved [491]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By 60 kDa heat shock protein, mitochondrial (HSPD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [492]
Etretinate DM2CZFA Keratosis ED56 Approved [220]
Methotrexate DM2TEOL Anterior urethra cancer Approved [207]
Quercetin DM3NC4M Obesity 5B81 Approved [493]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [160]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [139]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [494]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [61]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [81]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [495]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Histone H2AX (H2AX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [496]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [497]
Selenium DM25CGV N. A. N. A. Approved [37]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [498]
Etretinate DM2CZFA Keratosis ED56 Approved [499]
Methotrexate DM2TEOL Anterior urethra cancer Approved [500]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [501]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [502]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [503]
Quercetin DM3NC4M Obesity 5B81 Approved [504]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ATP synthase subunit alpha, mitochondrial (ATP5F1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [85]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [505]
Quercetin DM3NC4M Obesity 5B81 Approved [506]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [507]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [508]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [509]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [510]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [511]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [248]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein disulfide-isomerase A3 (PDIA3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [512]
Etretinate DM2CZFA Keratosis ED56 Approved [220]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [41]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [403]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Benzatropine DMF7EXL Parkinsonian disorder Approved [85]
Clozapine DMFC71L Schizophrenia 6A20 Approved [85]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By G1/S-specific cyclin-D2 (CCND2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [313]
Selenium DM25CGV N. A. N. A. Approved [102]
Methotrexate DM2TEOL Anterior urethra cancer Approved [115]
Quercetin DM3NC4M Obesity 5B81 Approved [116]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [513]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [514]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [515]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [221]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [83]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [42]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Heat shock 70 kDa protein 1-like (HSPA1L)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [516]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [394]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [160]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [161]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [484]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Isoproterenol DMK7MEY Atrioventricular block Approved [517]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [44]
Teriflunomide DMQ2FKJ Hyperlipidaemia 5C80 Approved [518]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Stress-70 protein, mitochondrial (HSPA9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [37]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [41]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [61]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [42]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [519]
Gallium nitrate DMF9O6B Hypercalcaemia 5B91.0 Approved [520]
Clozapine DMFC71L Schizophrenia 6A20 Approved [85]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [44]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [521]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [515]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [93]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [129]
Gefitinib DM15F0X Colon adenocarcinoma Approved [522]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [476]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [190]
Etretinate DM2CZFA Keratosis ED56 Approved [423]
Prednisone DM2HG4X Acute asthma CA23 Approved [523]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [488]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [241]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [524]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [127]
Gefitinib DM15F0X Colon adenocarcinoma Approved [525]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [467]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [131]
Quercetin DM3NC4M Obesity 5B81 Approved [208]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [494]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [526]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [131]
Ethacrynic acid DM60QMR Edema MG29 Approved [527]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 9 (MAPK9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [127]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [4]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [131]
Methotrexate DM2TEOL Anterior urethra cancer Approved [528]
Quercetin DM3NC4M Obesity 5B81 Approved [529]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [41]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [131]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [530]
Sorbitol DMAN0DE Constipation DD91.1 Approved [531]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Triosephosphate isomerase (TPI1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [37]
Etretinate DM2CZFA Keratosis ED56 Approved [220]
Methotrexate DM2TEOL Anterior urethra cancer Approved [479]
Quercetin DM3NC4M Obesity 5B81 Approved [493]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [50]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [509]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [532]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [510]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [42]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Peroxiredoxin-1 (PRDX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [533]
Etretinate DM2CZFA Keratosis ED56 Approved [220]
Methotrexate DM2TEOL Anterior urethra cancer Approved [115]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [149]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [160]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [139]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [19]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [311]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [139]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [510]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sialidase-1 (NEU1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [181]
Fluoxetine DM3PD2C Bipolar depression Approved [534]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [41]
Panobinostat DM58WKG Chronic graft versus host disease Approved [535]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [42]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [48]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [536]
Arsenic DMTL2Y1 N. A. N. A. Approved [35]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [355]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Eukaryotic translation initiation factor 2A (EIF2A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [537]
Quercetin DM3NC4M Obesity 5B81 Approved [77]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [133]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [538]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [539]
Cerulenin DM6N4PR Weight loss MG43.5 Approved [540]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [312]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [541]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Autophagy protein 5 (ATG5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gefitinib DM15F0X Colon adenocarcinoma Approved [435]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [542]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [438]
Trovafloxacin DM6AN32 Acute gonococcal cervicitis Approved [543]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [544]
Promethazine DM6I5GR Hyperemesis gravidarum Approved [440]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [545]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [20]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [546]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [59]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor protein 63 (TP63)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [39]
Quercetin DM3NC4M Obesity 5B81 Approved [547]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [228]
Panobinostat DM58WKG Chronic graft versus host disease Approved [548]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [218]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [84]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [549]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [44]
Topotecan DMP6G8T Central nervous system neoplasm Approved [550]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [32]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Actin, cytoplasmic 1 (ACTB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [4]
Selenium DM25CGV N. A. N. A. Approved [37]
Etretinate DM2CZFA Keratosis ED56 Approved [220]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [41]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [551]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [19]
Leflunomide DMR8ONJ Arthritis FA20 Approved [47]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [40]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dynein light chain Tctex-type 3 (DYNLT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [48]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [33]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [233]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [38]
Milchsaure DM462BT Pruritus EC90 Investigative [353]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [552]
KOJIC ACID DMP84CS Discovery agent N.A. Investigative [553]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Signal recognition particle 9 kDa protein (SRP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [20]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [44]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [32]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [554]
Urethane DM7NSI0 N. A. N. A. Phase 4 [60]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [38]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [555]
chloropicrin DMSGBQA Discovery agent N.A. Investigative [556]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Aldehyde dehydrogenase family 3 member B1 (ALDH3B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [187]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [39]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [41]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [83]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [24]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [32]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [307]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [36]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [299]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Leucine-rich repeat-containing protein 59 (LRRC59)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [117]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [42]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [414]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [359]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [36]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [136]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [555]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [22]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Aldehyde dehydrogenase, dimeric NADP-preferring (ALDH3A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [557]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [250]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [558]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [559]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [71]
Leflunomide DMR8ONJ Arthritis FA20 Approved [47]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [560]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [24]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [32]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (SAMHD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [41]
Leflunomide DMR8ONJ Arthritis FA20 Approved [47]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [42]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [248]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [344]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [48]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [110]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Alpha-actinin-4 (ACTN4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [37]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [561]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [325]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [24]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [359]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [36]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [37]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [562]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [563]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [42]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [24]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [44]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [355]
Methotrexate DM2TEOL Anterior urethra cancer Approved [390]
LY294002 DMY1AFS Neuroblastoma 2D11.2 Phase 1 [562]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By F-actin-capping protein subunit beta (CAPZB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [37]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [41]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [564]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [42]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Ethanol DMDRQZU Chronic pain MG30 Approved [298]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [24]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [321]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [36]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [136]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glutathione S-transferase Mu 2 (GSTM2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [187]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [41]
Testosterone DM7HUNW Hot flushes GA30 Approved [82]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [82]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [24]
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [565]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [566]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [567]
Arsenic DMTL2Y1 N. A. N. A. Approved [35]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor EB (TFEB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [37]
Fluphenazine DMIT8LX Psychotic disorder 6A20-6A25 Approved [568]
Prochlorperazine DM53SRA Nausea MD90 Approved [568]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [438]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [569]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [83]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [42]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [570]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [48]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [59]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Aldehyde dehydrogenase, mitochondrial (ALDH2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [571]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [41]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [572]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [311]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [573]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [574]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [42]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
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Drug(s) Affected By Ceruloplasmin (CP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [575]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [19]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [576]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [73]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [577]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Ampicillin DMHWE7P Acute epiglottitis Approved [40]
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Drug(s) Affected By Aldo-keto reductase family 1 member B10 (AKR1B10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [386]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [191]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [43]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [578]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [579]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [71]
Reserpine DM6VM38 Hypertension BA00-BA04 Approved [580]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [83]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [227]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Aldo-keto reductase family 1 member B1 (AKR1B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [41]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [581]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [582]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [20]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [227]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [140]
Benzoic Acid DMKB9FI Alopecia areata ED70.2 Approved [227]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cofilin-1 (CFL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [313]
Etretinate DM2CZFA Keratosis ED56 Approved [220]
Quercetin DM3NC4M Obesity 5B81 Approved [480]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [41]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [403]
Haloperidol DM96SE0 Delirium Approved [85]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [510]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [325]
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Drug(s) Affected By Alpha-actinin-1 (ACTN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [37]
Leflunomide DMR8ONJ Arthritis FA20 Approved [47]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [178]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [325]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [44]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [224]
Arsenic DMTL2Y1 N. A. N. A. Approved [35]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [45]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Alpha-aminoadipic semialdehyde dehydrogenase (ALDH7A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [78]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [510]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [24]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [154]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [44]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [32]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [26]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fructose-bisphosphate aldolase A (ALDOA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [37]
Etretinate DM2CZFA Keratosis ED56 Approved [220]
Methotrexate DM2TEOL Anterior urethra cancer Approved [479]
Quercetin DM3NC4M Obesity 5B81 Approved [480]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [149]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [41]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [317]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [118]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [75]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [73]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Adenylyl cyclase-associated protein 1 (CAP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [41]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [20]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [42]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [24]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [44]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [355]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [40]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [554]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [37]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Aldo-keto reductase family 1 member A1 (AKR1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [583]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [61]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [233]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [140]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [44]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [176]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [233]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [583]
Urethane DM7NSI0 N. A. N. A. Phase 4 [60]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By SERPINE1 mRNA-binding protein 1 (SERBP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [37]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [133]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [19]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Testosterone enanthate DMB6871 N. A. N. A. Approved [52]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [42]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [44]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [48]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [170]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Inhibitor of nuclear factor kappa-B kinase (IKK) TTRPDBG NOUNIPROTAC Inhibitor [2]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
NADPH:quinone reductase (CRYZ) Main DME DE8RYV5 QOR_HUMAN Substrate [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
14-3-3 protein eta OTP8NJFJ 1433F_HUMAN Gene/Protein Processing [4]
5-hydroxymethyl-dUMP N-hydrolase (DNPH1) OTEZVTI1 DNPH1_HUMAN Gene/Protein Processing [4]
60 kDa heat shock protein, mitochondrial (HSPD1) OTTO1Y11 CH60_HUMAN Protein Interaction/Cellular Processes [5]
Actin, cytoplasmic 1 (ACTB) OT1MCP2F ACTB_HUMAN Drug Response [6]
Adenomatous polyposis coli protein (APC) OTKV0TIK APC_HUMAN Gene/Protein Processing [4]
Adenosine receptor A1 (ADORA1) OTI7X39E AA1R_HUMAN Gene/Protein Processing [4]
Adenylyl cyclase-associated protein 1 (CAP1) OTYM8A2N CAP1_HUMAN Drug Response [6]
Aflatoxin B1 aldehyde reductase member 2 (AKR7A2) OTGEDDM2 ARK72_HUMAN Gene/Protein Processing [7]
Aldehyde dehydrogenase family 3 member B1 (ALDH3B1) OT5NEUQE AL3B1_HUMAN Drug Response [8]
Aldehyde dehydrogenase, dimeric NADP-preferring (ALDH3A1) OTAYZZE6 AL3A1_HUMAN Drug Response [9]

References

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521 Mitochondrial proteomics investigation of a cellular model of impaired dopamine homeostasis, an early step in Parkinson's disease pathogenesis. Mol Biosyst. 2014 Jun;10(6):1332-44.
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527 Characterization of cell death induced by ethacrynic acid in a human colon cancer cell line DLD-1 and suppression by N-acetyl-L-cysteine. Cancer Sci. 2003 Oct;94(10):886-93.
528 Methotrexate increases expression of cell cycle checkpoint genes via JNK activation. Arthritis Rheum. 2012 Jun;64(6):1780-9. doi: 10.1002/art.34342. Epub 2011 Dec 19.
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534 Screening autism-associated environmental factors in differentiating human neural progenitors with fractional factorial design-based transcriptomics. Sci Rep. 2023 Jun 29;13(1):10519. doi: 10.1038/s41598-023-37488-0.
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542 Low Autophagy (ATG) Gene Expression Is Associated with an Immature AML Blast Cell Phenotype and Can Be Restored during AML Differentiation Therapy. Oxid Med Cell Longev. 2018 Mar 18;2018:1482795. doi: 10.1155/2018/1482795. eCollection 2018.
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549 Bone marrow osteoblast damage by chemotherapeutic agents. PLoS One. 2012;7(2):e30758. doi: 10.1371/journal.pone.0030758. Epub 2012 Feb 17.
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552 A trichostatin A expression signature identified by TempO-Seq targeted whole transcriptome profiling. PLoS One. 2017 May 25;12(5):e0178302. doi: 10.1371/journal.pone.0178302. eCollection 2017.
553 Toxicogenomics of kojic acid on gene expression profiling of a375 human malignant melanoma cells. Biol Pharm Bull. 2006 Apr;29(4):655-69.
554 Expression Profiling of Human Pluripotent Stem Cell-Derived Cardiomyocytes Exposed to Doxorubicin-Integration and Visualization of Multi-Omics Data. Toxicol Sci. 2018 May 1;163(1):182-195. doi: 10.1093/toxsci/kfy012.
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556 Transcriptomic analysis of human primary bronchial epithelial cells after chloropicrin treatment. Chem Res Toxicol. 2015 Oct 19;28(10):1926-35.
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561 Simvastatin maintains steady patterns of GFR and improves AER and expression of slit diaphragm proteins in type II diabetes. Kidney Int. 2006 Jul;70(1):177-86. doi: 10.1038/sj.ki.5001515. Epub 2006 May 17.
562 Inhibition of angiogenesis by quercetin in tamoxifen-resistant breast cancer cells. Food Chem Toxicol. 2010 Nov;48(11):3227-34. doi: 10.1016/j.fct.2010.08.028. Epub 2010 Sep 4.
563 Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells. Nat Commun. 2018 Aug 9;9(1):3069. doi: 10.1038/s41467-018-05402-2.
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565 Astaxanthin and omega-3 fatty acids individually and in combination protect against oxidative stress via the Nrf2-ARE pathway. Food Chem Toxicol. 2013 Dec;62:869-75.
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