Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM2LJFZ)

• Drug Name: 4-hydroxy-2-nonenal Drug Info
• Synonyms: 4-Hydroxynonenal; 4-Hydroxy-2-nonenal; 4-hydroxynon-2-enal; trans-4-Hydroxy-2-nonenal; 4-Hydroxy-2,3-nonenal; 4-HNE; 75899-68-2; 4-hydroxy-2E-nonenal; (E)-4-hydroxynon-2-enal; CCRIS 9028; CCRIS 1781; 29343-52-0; 128946-65-6; 2-NONENAL, 4-HYDROXY-; HNE; (E)-4-hydroxy-2-nonenal; (2E)-4-hydroxynon-2-enal; (2E)-4-Hydroxy-2-nonenal; CHEMBL454280; CHEBI:58968; C9H16O2; (+/-)4-HYDROXYNON-2-ENAL; NCGC00161254-02; 4-hydroxynonen-2-al; CHEBI:32585; CCRIS 6927; 4 hydroxynonenal; (E)-4-Hydroxynonenal; AC1Q2VOQ; 4HNE; SCHEMBL3920; AC1Q6PP5; AC1NR22M

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 5283344
  ChEBI ID: CHEBI:58968
  CAS Number: CAS 75899-68-2
  TTD Drug ID: DM2LJFZ
  INTEDE Drug ID: DR2062

Molecule-Related Drug Atlas

Drug(s) Targeting Inhibitor of nuclear factor kappa-B kinase (IKK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dihydrothieno [2,3-e]indazole derivative 1	DMUJ3XK	N. A.	N. A.	Patented	[9]
Dihydrothieno [2,3-e]indazole derivative 4	DMR4LPO	N. A.	N. A.	Patented	[9]
Dihydrothieno [2,3-e]indazole derivative 3	DM85VQR	N. A.	N. A.	Patented	[9]
Dihydrothieno [2,3-e]indazole derivative 2	DM0D3HU	N. A.	N. A.	Patented	[9]
PMID23099093C17d	DMWS7O9	Discovery agent	N.A.	Investigative	[10]
Arsenite	DMBCO4Q	Discovery agent	N.A.	Investigative	[11]
5-Bromo-6-methoxy-9H-beta-carboline	DM157OQ	Discovery agent	N.A.	Investigative	[12]
MRT67307	DMYRCHG	Discovery agent	N.A.	Investigative	[13]
PS-1145	DMVUMWZ	Multiple myeloma	2A83	Investigative	[14]
BMS-345541	DM7D519	Arthritis	FA20	Investigative	[15]

Drug(s) Metabolized By NADPH:quinone reductase (CRYZ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[16]
1,2-NAPHTHOQUINONE	DMYXELH	Discovery agent	N.A.	Investigative	[17]
Hexylacrolein	DMBC8KM	N. A.	N. A.	Investigative	[3]
Acetyl ethylene	DMUH4N7	N. A.	N. A.	Investigative	[3]
J-009747	DMQSB6N	N. A.	N. A.	Investigative	[3]

Drug(s) Affected By Quinone oxidoreductase (CRYZ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[18]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[24]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[25]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[27]

Drug(s) Affected By DNA fragmentation factor subunit alpha (DFFA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[29]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[31]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[32]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[33]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[34]

Drug(s) Affected By Phosphatidylinositol 3-kinase regulatory subunit beta (PIK3R2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[36]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[34]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[37]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[38]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[39]

Drug(s) Affected By Peripheral plasma membrane protein CASK (CASK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[35]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[40]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[42]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[44]

Drug(s) Affected By Cyclin-G-associated kinase (GAK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Baricitinib	DM4ONW5	Rheumatoid arthritis	FA20	Approved	[45]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[46]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[47]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[48]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[49]

Drug(s) Affected By Transcription intermediary factor 1-alpha (TRIM24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[47]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[50]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[51]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[46]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[24]

Drug(s) Affected By Linker for activation of T-cells family member 1 (LAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[53]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[40]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[34]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[55]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[56]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[48]

Drug(s) Affected By Protein sprouty homolog 2 (SPRY2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[49]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[41]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[50]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[58]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[34]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]

Drug(s) Affected By 5-hydroxymethyl-dUMP N-hydrolase (DNPH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[50]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[61]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[34]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[62]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]

Drug(s) Affected By Cyclin-T1 (CCNT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[50]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[64]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[65]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[66]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[67]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[66]

Drug(s) Affected By Nibrin (NBN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[29]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[70]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[71]

Drug(s) Affected By Transcriptional adapter 3 (TADA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[47]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[34]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[47]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[48]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[73]

Drug(s) Affected By PR domain zinc finger protein 1 (PRDM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[76]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[77]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[78]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[79]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[79]
Ibrutinib	DMHZCPO	Mantle cell lymphoma	2A85.5	Approved	[80]

Drug(s) Affected By Cyclin-K (CCNK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[82]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[66]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[48]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[83]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[84]
NS398	DMINUWH	Endometriosis	GA10	Terminated	[85]

Drug(s) Affected By DNA fragmentation factor subunit beta (DFFB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[86]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[87]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[29]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[77]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[88]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[88]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]

Drug(s) Affected By Elongator complex protein 1 (ELP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[47]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[87]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[87]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[64]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[24]

Drug(s) Affected By Neuroendocrine secretory protein 55 (GNAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Selenium	DM25CGV	N. A.	N. A.	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[76]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[89]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[18]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[64]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[37]

Drug(s) Affected By Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[31]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[93]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Hydroxychloroquine	DMSIVND	Chronic renal failure	GB61.Z	Approved	[94]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[95]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[96]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]

Drug(s) Affected By Protein c-Fos (FOS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[35]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[97]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[98]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[99]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[98]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[100]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[101]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[102]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[103]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[104]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[99]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[100]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[105]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[53]
Selenium	DM25CGV	N. A.	N. A.	Approved	[106]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[107]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[108]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[109]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[110]

Drug(s) Affected By Proenkephalin-B (PDYN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[76]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[50]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[60]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[111]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[64]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[112]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[112]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[113]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[114]

Drug(s) Affected By Phosphatidylcholine-sterol acyltransferase (LCAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[115]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[116]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[117]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[112]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[112]

Drug(s) Affected By Receptor tyrosine-protein kinase erbB-2 (ERBB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Trastuzumab	DMZQOUX	Breast cancer	2C60-2C65	Approved	[118]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[119]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[120]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[100]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[121]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Selenium	DM25CGV	N. A.	N. A.	Approved	[47]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[122]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]

Drug(s) Affected By Calpain small subunit 1 (CAPNS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Selenium	DM25CGV	N. A.	N. A.	Approved	[47]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[124]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[125]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[34]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[62]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[126]

Drug(s) Affected By Amyloid-beta precursor protein (APP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Selenium	DM25CGV	N. A.	N. A.	Approved	[47]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[110]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[127]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[130]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[35]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[131]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[132]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[133]
Fructose	DM43AN2	Vomiting	MD90	Approved	[118]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[134]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[135]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[99]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[136]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[138]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[139]

Drug(s) Affected By Tyrosine-protein kinase Lck (LCK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[141]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[125]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[142]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[143]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[144]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[145]

Drug(s) Affected By DNA polymerase beta (POLB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[146]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[89]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[50]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[147]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[148]
Colistin	DMMD9QE	Pseudomonas infection	1B92	Approved	[118]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[149]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[150]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[151]

Drug(s) Affected By Procathepsin L (CTSL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[152]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[153]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[50]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[154]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[155]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[156]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[153]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]

Drug(s) Affected By Tyrosine-protein kinase Lyn (LYN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[49]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[76]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[125]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[157]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[50]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[158]

Drug(s) Affected By Insulin-like growth factor 1 receptor (IGF1R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[159]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[160]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[161]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[162]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[163]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[164]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[165]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[88]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[88]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[79]

Drug(s) Affected By Synaptophysin (SYP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[89]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[167]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[166]
Abacavir	DMMN36E	Human immunodeficiency virus infection	1C62	Approved	[168]
Methamphetamine	DMPM4SK	Anxiety		Approved	[169]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[38]

Drug(s) Affected By Integrin alpha-5 (ITGA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[170]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[110]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[171]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[172]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[173]

Drug(s) Affected By Interleukin-3 (IL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[110]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[174]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[174]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[31]
Betamethasone Valerate	DMMIAXO	Dermatological disease	DA24.Y	Approved	[175]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[176]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[114]
Tacrolimus	DMZ7XNQ	Graft-versus-host disease	4B24	Approved	[175]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[118]
Famotidine	DMRL3AB	Gastric ulcer	DA60	Approved	[118]

Drug(s) Affected By Interleukin-6 receptor subunit alpha (IL6R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[177]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[115]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[178]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[179]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[180]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[181]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[155]

Drug(s) Affected By Neuromedin-B (NMB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[182]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[182]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[184]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[185]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[34]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[182]

Drug(s) Affected By C-C motif chemokine 3 (CCL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[186]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[110]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[187]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[188]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[189]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[190]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[191]
Betamethasone	DMAHJEF	Acute adrenal insufficiency		Approved	[180]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[180]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[186]

Drug(s) Affected By Myb-related protein B (MYBL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[192]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[157]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[193]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[184]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[88]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[157]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[194]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[195]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]

Drug(s) Affected By Nuclear receptor subfamily 2 group F member 6 (NR2F6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[196]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[34]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[37]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[24]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[196]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[37]

Drug(s) Affected By Retinoic acid receptor beta (RARB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[197]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[198]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[199]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[76]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[200]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[201]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[202]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[203]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[197]

Drug(s) Affected By Fibroblast growth factor receptor 1 (FGFR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[193]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[53]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[204]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[204]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[205]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]

Drug(s) Affected By DNA topoisomerase 1 (TOP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Teniposide	DMLW57T	Acute lymphoblastic leukaemia	2A85	Approved	[118]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[206]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[19]
Selenium	DM25CGV	N. A.	N. A.	Approved	[47]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[207]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[208]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]

Drug(s) Affected By DNA topoisomerase 2-alpha (TOP2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[210]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[211]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[136]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[212]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[213]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[208]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[214]

Drug(s) Affected By Bone morphogenetic protein 1 (BMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[122]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[198]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[33]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[215]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[216]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[217]
Seocalcitol	DMKL9QO	Rickets	5B57	Phase 3	[218]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[219]

Drug(s) Affected By Hepatocyte growth factor (HGF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[220]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[221]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[222]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[53]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[223]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[224]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[225]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[226]

Drug(s) Affected By Protein C-ets-1 (ETS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[227]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[228]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[76]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[35]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[229]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[230]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[158]

Drug(s) Affected By Protein C-ets-2 (ETS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[35]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[231]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[41]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[232]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[233]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[234]

Drug(s) Affected By Serine/threonine-protein kinase B-raf (BRAF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[235]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[236]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[50]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[117]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[37]
Famotidine	DMRL3AB	Gastric ulcer	DA60	Approved	[237]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[238]

Drug(s) Affected By Interleukin-9 (IL9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[96]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[239]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[240]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[239]

Drug(s) Affected By Ezrin (EZR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[18]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[19]
Selenium	DM25CGV	N. A.	N. A.	Approved	[47]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[122]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[57]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[76]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[241]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[242]
Haloperidol	DM96SE0	Delirium		Approved	[18]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[54]

Drug(s) Affected By Transcription factor E2-alpha (TCF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[37]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[243]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[46]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[216]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[244]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[66]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[37]

Drug(s) Affected By Cyclic AMP-responsive element-binding protein 1 (CREB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[245]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[246]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Selenium	DM25CGV	N. A.	N. A.	Approved	[47]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[247]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[248]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[249]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[249]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[250]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[251]

Drug(s) Affected By SH2/SH3 adapter protein NCK1 (NCK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[158]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[252]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[253]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[243]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[27]

Drug(s) Affected By Neuroendocrine convertase 2 (PCSK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[254]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[254]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[255]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[217]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[66]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[48]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[49]

Drug(s) Affected By Carboxypeptidase E (CPE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[76]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[190]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[50]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[201]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[34]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[256]

Drug(s) Affected By Interleukin-7 receptor subunit alpha (IL7R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[247]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[125]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[78]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[40]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[257]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[36]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[34]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[258]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[259]

Drug(s) Affected By High mobility group protein HMG-I/HMG-Y (HMGA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[260]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[261]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]
Methamphetamine	DMPM4SK	Anxiety		Approved	[262]

Drug(s) Affected By Transcription factor JunD (JUND)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[135]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[99]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[228]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[235]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[87]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[263]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[53]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[242]

Drug(s) Affected By Calpain-2 catalytic subunit (CAPN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[264]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[265]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[266]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[125]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[88]
Glibenclamide	DM8JXPZ	Diabetic complication	5A2Y	Approved	[265]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[88]

Drug(s) Affected By Tyrosine-protein phosphatase non-receptor type 1 (PTPN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[241]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[50]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Benzoic Acid	DMKB9FI	Alopecia areata	ED70.2	Approved	[267]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[268]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[269]
Seocalcitol	DMKL9QO	Rickets	5B57	Phase 3	[218]
URSOLIC ACID	DM4SOAW	Metabolic syndrome x	5C50-5D2Z	Phase 2	[270]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[271]

Drug(s) Affected By General transcription and DNA repair factor IIH helicase subunit XPD (ERCC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[197]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[241]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[31]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[55]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[39]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[272]

Drug(s) Affected By Glutathione peroxidase 2 (GPX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[273]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[274]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[275]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[115]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[276]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[277]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[263]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[77]

Drug(s) Affected By Integrin beta-6 (ITGB6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[88]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[89]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[278]
Bortezomib	DMNO38U	Leukemia		Approved	[33]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[279]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[280]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]

Drug(s) Affected By Cadherin-2 (CDH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[221]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[166]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[76]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[281]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[282]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[283]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[284]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[229]

Drug(s) Affected By ETS domain-containing protein Elk-1 (ELK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[119]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[285]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[286]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[287]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[288]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[33]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[34]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[118]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[289]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[290]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[207]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[291]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[292]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[87]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[35]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[231]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[293]

Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[294]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[242]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[99]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[295]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[296]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[297]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[298]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[299]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[291]

Drug(s) Affected By Cyclin-A2 (CCNA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[119]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[300]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[100]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[274]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[301]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[302]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[213]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[303]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[304]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]

Drug(s) Affected By Catechol O-methyltransferase (COMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[305]
Dobutamine	DMD1B8Z	Heart failure	BD10-BD13	Approved	[305]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[305]
Modafinil	DMYILBE	Malignant glioma	2A00.0	Approved	[306]
Levodopa	DMN3E57	Parkinson disease	8A00.0	Approved	[305]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[196]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Tolcapone	DM8MNVO	Parkinson disease	8A00.0	Approved	[307]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]

Drug(s) Affected By Cadherin-3 (CDH3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Selenium	DM25CGV	N. A.	N. A.	Approved	[47]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[221]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[76]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[184]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[221]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[308]

Drug(s) Affected By Nucleoside diphosphate kinase B (NME2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[309]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[40]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[310]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[311]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[312]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[309]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[62]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[313]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[314]

Drug(s) Affected By Ferrochelatase, mitochondrial (FECH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Selenium	DM25CGV	N. A.	N. A.	Approved	[47]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[315]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[79]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[79]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[316]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[50]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[79]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[158]
Benzoic Acid	DMKB9FI	Alopecia areata	ED70.2	Approved	[316]

Drug(s) Affected By Integrin alpha-6 (ITGA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[170]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[19]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[317]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[198]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[318]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[236]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[89]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[50]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[233]

Drug(s) Affected By Trans-acting T-cell-specific transcription factor GATA-3 (GATA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[19]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[110]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[221]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[319]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[320]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[76]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[321]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[205]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[322]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]

Drug(s) Affected By Adenomatous polyposis coli protein (APC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Selenium	DM25CGV	N. A.	N. A.	Approved	[47]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[291]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[184]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[323]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[232]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[202]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[31]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[42]

Drug(s) Affected By Proteinase-activated receptor 1 (F2R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[136]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Selenium	DM25CGV	N. A.	N. A.	Approved	[47]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[324]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[325]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[77]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[326]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[326]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]

Drug(s) Affected By MAP/microtubule affinity-regulating kinase 3 (MARK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[268]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[67]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[48]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[83]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[83]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[327]

Drug(s) Affected By DNA polymerase delta catalytic subunit (POLD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[328]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[236]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[88]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[46]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]

Drug(s) Affected By Retinoic acid receptor RXR-beta (RXRB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[329]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[54]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[59]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[50]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[331]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[332]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[333]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[332]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[334]

Drug(s) Affected By DNA excision repair protein ERCC-5 (ERCC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[228]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[228]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[34]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[335]
Ximelegatran	DMU8ANS	Myocardial infarction	BA41-BA43	Approved	[336]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[337]
Seocalcitol	DMKL9QO	Rickets	5B57	Phase 3	[218]

Drug(s) Affected By M-phase inducer phosphatase 1 (CDC25A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[328]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[338]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[339]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[340]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[341]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[231]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[342]

Drug(s) Affected By Adenosine receptor A1 (ADORA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[196]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[295]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[88]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[88]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Adenosine	DMM2NSK	Paroxysmal supraventricular tachycardia	BC81.Z	Approved	[343]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[62]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[114]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[65]

Drug(s) Affected By Transcription factor HIVEP2 (HIVEP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[344]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[345]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[346]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]

Drug(s) Affected By C-C chemokine receptor type 1 (CCR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[89]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[50]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[252]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[55]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[347]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[24]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[140]

Drug(s) Affected By DNA replication licensing factor MCM4 (MCM4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[328]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[303]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[291]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[35]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[88]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[195]

Drug(s) Affected By Catenin beta-1 (CTNNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[134]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[348]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[163]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[349]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[350]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[351]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[352]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[284]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[353]

Drug(s) Affected By Prohibitin 1 (PHB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[18]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[157]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[242]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[81]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[157]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[354]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[355]

Drug(s) Affected By Merlin (NF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Selenium	DM25CGV	N. A.	N. A.	Approved	[47]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[207]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[356]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[357]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[64]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[19]

Drug(s) Affected By Serpin B5 (SERPINB5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[274]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[122]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[358]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[205]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[359]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[79]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[360]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[361]

Drug(s) Affected By Homeobox protein cut-like 1 (CUX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[55]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[46]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[24]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[66]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[362]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[363]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[47]

Drug(s) Affected By Interleukin-6 receptor subunit beta (IL6ST)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[364]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[365]
Selenium	DM25CGV	N. A.	N. A.	Approved	[47]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[115]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[366]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[326]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[326]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[88]

Drug(s) Affected By DNA mismatch repair protein Mlh1 (MLH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[295]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[232]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[62]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[367]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[368]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[216]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[369]

Drug(s) Affected By DNA-binding protein inhibitor ID-1 (ID1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[370]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[371]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Selenium	DM25CGV	N. A.	N. A.	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[318]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[372]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[77]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[184]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]

Drug(s) Affected By ETS translocation variant 3 (ETV3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[57]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[373]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[374]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[48]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[375]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[376]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[83]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[327]

Drug(s) Affected By Transcription factor ETV6 (ETV6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[377]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[252]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[361]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[24]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[66]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[377]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[377]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[378]

Drug(s) Affected By Myeloid cell nuclear differentiation antigen (MNDA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[189]
Coprexa	DMA0WEK	Neurological disorder	6B60	Phase 3	[379]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[380]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[83]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[381]

Drug(s) Affected By Hepatocyte nuclear factor 4-alpha (HNF4A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[382]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[161]
Fructose	DM43AN2	Vomiting	MD90	Approved	[383]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[384]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
SR141716A	DMCO5JZ	Obesity	5B81	Approved	[385]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[386]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[387]
Estriol	DMOEM2I	Hormone deficiency	5A61.1	Approved	[388]

Drug(s) Affected By Signal transducer and activator of transcription 6 (STAT6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[364]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[389]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[207]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[320]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[76]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[321]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[389]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[34]

Drug(s) Affected By Serine/threonine-protein kinase mTOR (MTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[390]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[289]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[391]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[392]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[393]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[107]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[394]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[395]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[236]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[396]

Drug(s) Affected By Epidermal growth factor receptor substrate 15 (EPS15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[295]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[165]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[232]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[397]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[48]

Drug(s) Affected By Interleukin-12 receptor subunit beta-1 (IL12RB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[398]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[46]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[398]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[114]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[399]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[56]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[400]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[36]
Dimethylallyl Diphosphate	DMP5I47	Discovery agent	N.A.	Investigative	[401]

Drug(s) Affected By C-X-C motif chemokine 5 (CXCL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[328]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[402]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[76]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[241]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[50]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[403]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[404]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[158]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[405]

Drug(s) Affected By Radiation-inducible immediate-early gene IEX-1 (IER3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[406]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Selenium	DM25CGV	N. A.	N. A.	Approved	[407]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[322]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[76]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[77]

Drug(s) Affected By MARCKS-related protein (MARCKSL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[40]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[404]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[34]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[408]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[24]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[409]

Drug(s) Affected By Amphiphysin (AMPH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[40]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[50]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[355]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[345]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[217]

Drug(s) Affected By Dual specificity protein kinase CLK3 (CLK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[35]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[125]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[410]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[408]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]

Drug(s) Affected By Adenosine 5'-monophosphoramidase HINT1 (HINT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[36]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[62]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[24]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[411]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[412]
EXISULIND	DMBY56U	Colorectal cancer	2B91.Z	Phase 3	[413]

Drug(s) Affected By Tuberin (TSC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Selenium	DM25CGV	N. A.	N. A.	Approved	[47]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[110]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[123]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[414]
Methamphetamine	DMPM4SK	Anxiety		Approved	[415]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[82]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[416]

Drug(s) Affected By Glycogen synthase kinase-3 beta (GSK3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[264]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[417]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[418]
Selenium	DM25CGV	N. A.	N. A.	Approved	[47]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[419]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[420]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[291]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[421]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[422]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1C (CDKN1C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[19]
Selenium	DM25CGV	N. A.	N. A.	Approved	[47]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[303]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[423]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[423]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[77]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[89]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[33]

Drug(s) Affected By Cyclin-dependent kinase 9 (CDK9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[424]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[216]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[425]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[67]

Drug(s) Affected By Rho GDP-dissociation inhibitor 1 (ARHGDIA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Selenium	DM25CGV	N. A.	N. A.	Approved	[47]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[309]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[57]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[426]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[427]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[50]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[28]

Drug(s) Affected By Ephrin-A4 (EFNA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[19]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[57]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[268]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]

Drug(s) Affected By Death-associated protein kinase 1 (DAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[57]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[88]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[31]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[428]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[429]

Drug(s) Affected By Telomeric repeat-binding factor 1 (TERF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[47]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[430]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[232]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[261]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[64]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[66]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[431]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[47]

Drug(s) Affected By Heat shock-related 70 kDa protein 2 (HSPA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[406]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[19]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[146]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[188]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[124]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[432]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[433]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[50]

Drug(s) Affected By Sodium/potassium-transporting ATPase subunit beta-3 (ATP1B3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[434]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[89]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[345]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[46]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[38]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[435]

Drug(s) Affected By Cyclin-dependent kinase 4 inhibitor D (CDKN2D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[436]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[437]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[438]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[164]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[88]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[439]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[31]

Drug(s) Affected By Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PPP1CA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[434]
Selenium	DM25CGV	N. A.	N. A.	Approved	[47]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[124]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[34]
Amiloride	DMRTSGP	Congestive heart failure	BD10	Approved	[440]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[255]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Aminoglutethimide	DMWFHMZ	Cushing disease	5A70	Approved	[441]

Drug(s) Affected By Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (GNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[442]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[443]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[255]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[46]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[66]

Drug(s) Affected By Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (GNB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[295]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Selenium	DM25CGV	N. A.	N. A.	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[125]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[50]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[444]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[38]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[445]

Drug(s) Affected By Casein kinase I isoform gamma-2 (CSNK1G2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[46]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[47]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[48]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[375]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[49]

Drug(s) Affected By DNA-dependent protein kinase catalytic subunit (PRKDC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[206]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[434]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[163]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[87]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[446]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[184]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[447]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[36]

Drug(s) Affected By Transcription initiation factor IIB (GTF2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[228]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[184]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[34]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[24]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[67]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[397]

Drug(s) Affected By Transcription factor E2F1 (E2F1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[448]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[406]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[449]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[450]
Selenium	DM25CGV	N. A.	N. A.	Approved	[47]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[338]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[302]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[303]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]

Drug(s) Affected By DNA-binding protein SATB1 (SATB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[49]
Selenium	DM25CGV	N. A.	N. A.	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[451]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[77]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[40]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[50]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[344]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[452]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[55]

Drug(s) Affected By Transcription factor Sp2 (SP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[439]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[453]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[67]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[48]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[83]

Drug(s) Affected By Dystonin (DST)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[49]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[76]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[241]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[323]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[453]

Drug(s) Affected By Tumor necrosis factor alpha-induced protein 2 (TNFAIP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[47]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[182]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[182]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[77]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[454]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]

Drug(s) Affected By Proto-oncogene c-Rel (REL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[455]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[456]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[457]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[410]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[36]
Norepinephrine	DMOUC09	Alopecia	ED70	Approved	[458]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[459]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[460]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[96]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[461]

Drug(s) Affected By Focal adhesion kinase 1 (PTK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[462]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[463]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[303]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[464]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[235]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[465]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[466]
Halothane	DM80OZ5	Anaesthesia	9A78.6	Approved	[467]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[89]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[50]

Drug(s) Affected By Tight junction protein ZO-1 (TJP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[468]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[122]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[184]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[232]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[469]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[470]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[471]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[472]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[406]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[473]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[197]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[474]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[475]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[476]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[477]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[478]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[479]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[480]
Selenium	DM25CGV	N. A.	N. A.	Approved	[47]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[481]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[122]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[482]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[483]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[291]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[187]

Drug(s) Affected By Protein phosphatase 3 catalytic subunit alpha (PPP3CA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[456]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[484]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[18]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[158]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[256]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[24]

Drug(s) Affected By Leukocyte surface antigen CD47 (CD47)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[364]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[34]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[256]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[55]

Drug(s) Affected By Retinoblastoma-like protein 2 (RBL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[485]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[486]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[59]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[487]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[31]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]

Drug(s) Affected By Cell division cycle protein 20 homolog (CDC20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[328]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[488]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[213]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[57]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[489]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[88]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[88]

Drug(s) Affected By Epidermal growth factor receptor kinase substrate 8 (EPS8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[19]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[490]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[18]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[345]

Drug(s) Affected By Ral guanine nucleotide dissociation stimulator (RALGDS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[89]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[232]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[36]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[452]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[55]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[24]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[66]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[219]

Drug(s) Affected By BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[303]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[87]
Quinolones	DM5GVHU	Bacterial infection	1A00-1C4Z	Approved	[491]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[492]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[432]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[40]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[79]

Drug(s) Affected By Transcriptional repressor NF-X1 (NFX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[50]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[24]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[83]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[83]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[493]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[494]

Drug(s) Affected By Tetraspanin-31 (TSPAN31)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[88]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[88]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[50]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[112]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[112]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[216]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[66]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[495]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[496]

Drug(s) Affected By Rho GTPase-activating protein 5 (ARHGAP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[207]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[76]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[35]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[50]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[252]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[27]

Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 5 (MAP2K5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[125]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[50]
Hesperidin	DMI5DW1	Vascular purpura	3B60	Approved	[497]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[37]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[95]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[46]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[216]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[498]

Drug(s) Affected By E3 ubiquitin-protein ligase CBL-B (CBLB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Selenium	DM25CGV	N. A.	N. A.	Approved	[47]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[207]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[50]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[31]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[114]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[44]

Drug(s) Affected By DnaJ homolog subfamily C member 3 (DNAJC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[87]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[165]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[40]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[195]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[499]

Drug(s) Affected By Methanethiol oxidase (SELENBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[500]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[426]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[34]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[345]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[426]
Estriol	DMOEM2I	Hormone deficiency	5A61.1	Approved	[426]

Drug(s) Affected By Serine/threonine-protein kinase ATR (ATR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[87]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[501]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[502]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[503]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[447]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[50]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[87]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[504]

Drug(s) Affected By Integrin alpha-7 (ITGA7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[357]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[345]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[505]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[506]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[217]

Drug(s) Affected By Interleukin-18 (IL18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[364]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[110]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[507]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[508]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[509]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[89]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[357]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[510]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[357]

Drug(s) Affected By Transcription factor Dp-2 (TFDP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[454]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[50]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[31]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[42]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[346]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[55]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[460]

Drug(s) Affected By Src substrate cortactin (CTTN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[511]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[79]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[79]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]

Drug(s) Affected By Fas-activated serine/threonine kinase (FASTK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[423]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[423]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[40]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[59]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[453]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[31]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[34]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[423]
Bortezomib	DMNO38U	Leukemia		Approved	[33]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]

Drug(s) Affected By Endoplasmic reticulum membrane sensor NFE2L1 (NFE2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[228]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[232]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[313]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[512]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[243]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[513]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[38]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[514]

Drug(s) Affected By Caspase-8 (CASP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[515]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[516]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[517]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[364]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[518]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[519]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[480]
Selenium	DM25CGV	N. A.	N. A.	Approved	[47]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[520]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[110]

Drug(s) Affected By Nuclear factor 1 X-type (NFIX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[207]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[184]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[386]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[344]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[521]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 3 (NR1I3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[522]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[523]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[524]
Artemether	DM48QOT	Malaria	1F40-1F45	Approved	[525]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[526]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[263]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[527]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[528]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[529]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]

Drug(s) Affected By Nectin-1 (NECTIN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[57]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[54]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[112]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[112]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[498]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[530]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[531]

Drug(s) Affected By Receptor tyrosine-protein kinase erbB-4 (ERBB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[57]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[164]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[40]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[532]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[533]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[534]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[252]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[46]

Drug(s) Affected By Ribosomal protein S6 kinase alpha-2 (RPS6KA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[49]
Selenium	DM25CGV	N. A.	N. A.	Approved	[47]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[115]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[77]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[50]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[201]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[535]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[536]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[112]

Drug(s) Affected By Elongin-C (ELOC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[46]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[216]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[66]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[537]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[493]
Okadaic acid	DM47CO1	Discovery agent	N.A.	Investigative	[538]

Drug(s) Affected By Myosin light chain kinase, smooth muscle (MYLK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[539]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[76]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[269]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[88]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[229]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[50]

Drug(s) Affected By Mothers against decapentaplegic homolog 1 (SMAD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[53]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[184]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[36]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[540]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[118]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[541]

Drug(s) Affected By Intersectin-1 (ITSN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[40]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[542]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[48]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[375]

Drug(s) Affected By Interleukin-17A (IL17A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[110]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[543]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[544]
Paroxetine	DM5PVQE	Anxiety disorder	6B00-6B0Z	Approved	[545]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[546]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[547]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[174]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[548]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[549]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[550]

Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[551]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[274]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[552]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[506]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[553]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[554]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[555]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[556]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[557]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[371]

Drug(s) Affected By Discoidin domain-containing receptor 2 (DDR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[558]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[232]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[34]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[559]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[560]

Drug(s) Affected By Nuclear factor related to kappa-B-binding protein (NFRKB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[46]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[76]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[374]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[400]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[375]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[83]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[83]
QUERCITRIN	DM1DH96	Discovery agent	N.A.	Investigative	[561]

Drug(s) Affected By TRAF family member-associated NF-kappa-B activator (TANK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[40]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[562]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[36]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[31]
Bortezomib	DMNO38U	Leukemia		Approved	[33]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[37]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[563]

Drug(s) Affected By Neogenin (NEO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[564]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[201]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[453]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[58]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[34]

Drug(s) Affected By Bcl2-associated agonist of cell death (BAD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[565]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[472]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[364]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[566]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[567]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[568]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[115]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[569]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[29]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[231]

Drug(s) Affected By P2X purinoceptor 5 (P2RX5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[89]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[36]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[38]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[498]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[570]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[76]

Drug(s) Affected By Far upstream element-binding protein 1 (FUBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[318]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[571]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[50]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[18]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[460]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[46]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[24]

Drug(s) Affected By Proheparin-binding EGF-like growth factor (HBEGF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[273]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[572]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[573]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[423]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[423]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[373]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[77]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[184]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[88]

Drug(s) Affected By Neuroserpin (SERPINI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[88]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[36]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[24]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[574]

Drug(s) Affected By Tumor susceptibility gene 101 protein (TSG101)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[49]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[198]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[575]
Camptothecin	DM6CHNJ	Solid tumour/cancer	2A00-2F9Z	Phase 3	[576]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[49]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[577]

Drug(s) Affected By Polyadenylate-binding protein-interacting protein 1 (PAIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[57]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[578]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[50]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[36]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[578]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[578]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[578]

Drug(s) Affected By Leucine-rich repeat protein SHOC-2 (SHOC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[19]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[323]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]

Drug(s) Affected By Serum paraoxonase/arylesterase 1 (PON1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[579]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[580]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[581]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[582]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[583]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[584]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[76]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[585]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[586]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[579]

Drug(s) Affected By Cocaine esterase (CES2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[587]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[588]
Dextropropoxyphene	DM23HCX	Pain	MG30-MG3Z	Approved	[589]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[207]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[590]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[591]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[59]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[592]

Drug(s) Affected By Liver carboxylesterase 1 (CES1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[593]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[97]
Dextropropoxyphene	DM23HCX	Pain	MG30-MG3Z	Approved	[589]
Selenium	DM25CGV	N. A.	N. A.	Approved	[47]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[594]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[595]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[587]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[77]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[442]

Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[596]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[597]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[99]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[598]
Selenium	DM25CGV	N. A.	N. A.	Approved	[47]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[599]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[600]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[601]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[602]

Drug(s) Affected By Aflatoxin B1 aldehyde reductase member 2 (AKR7A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[603]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[55]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[243]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[604]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[27]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[605]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[606]

Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[79]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[607]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[273]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[598]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[608]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[609]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[600]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[601]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[610]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[221]

Drug(s) Affected By Aldo-keto reductase family 1 member C3 (AKR1C3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[611]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[612]
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[613]
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[613]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[611]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[611]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[614]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[615]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[57]

Drug(s) Affected By Toll-like receptor 4 (TLR4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[110]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[616]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[617]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[184]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[618]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[619]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[616]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[79]

Drug(s) Affected By Tumor protein p73 (TP73)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[620]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[49]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[621]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[622]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[89]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[31]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[623]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[621]

Drug(s) Affected By Microphthalmia-associated transcription factor (MITF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[246]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[624]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[198]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[625]
Vemurafenib	DM62UG5	Melanoma	2C30	Approved	[626]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[50]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]

Drug(s) Affected By Transient receptor potential cation channel subfamily A member 1 (TRPA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[97]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[627]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[628]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[58]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[627]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[629]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[66]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[630]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[495]

Drug(s) Affected By Ubiquitin-like modifier-activating enzyme ATG7 (ATG7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[392]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[631]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[632]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[263]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[633]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[634]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[635]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[263]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[636]

Drug(s) Affected By GDH/6PGL endoplasmic bifunctional protein (H6PD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[47]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[637]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[564]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[638]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[638]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[34]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[42]

Drug(s) Affected By Mitochondrial uncoupling protein 4 (SLC25A27)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[24]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[244]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[498]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[67]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[375]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[639]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[493]

Drug(s) Affected By Angiotensinogen (AGT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[640]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[641]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[19]
Reboxetine	DM26PRD	Depression	6A70-6A7Z	Approved	[642]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[643]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[644]
Rhucin	DM3ADGP	Erectile dysfunction	HA01.1	Approved	[645]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Lisinopril	DMUOK4C	Chronic heart failure	BD1Z	Approved	[646]
Irbesartan	DMTP1DC	Diabetic kidney disease	GB61.Z	Approved	[647]

Drug(s) Affected By Metalloproteinase inhibitor 1 (TIMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pentoxifylline	DMU3DNC	Alcoholic hepatitis	DB94.1	Approved	[118]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[648]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[649]
Selenium	DM25CGV	N. A.	N. A.	Approved	[650]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[649]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[651]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[115]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[652]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[653]

Drug(s) Affected By Collagen alpha-1(I) chain (COL1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[118]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[654]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[170]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[197]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[655]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[317]
Ceruletide	DM2WE5K	Caerulein stimulated gastric and pancreatic secretion	5A4Y	Approved	[656]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[657]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[658]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[659]

Drug(s) Affected By Apolipoprotein A-I (APOA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[660]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[661]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[115]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[662]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[586]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[116]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[663]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[354]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[664]

Drug(s) Affected By Interstitial collagenase (MMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[328]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[665]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[666]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[667]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[122]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[668]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[669]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[670]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[671]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[53]

Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[455]
Selenium	DM25CGV	N. A.	N. A.	Approved	[407]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[182]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[601]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[672]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[673]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[221]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[115]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[674]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[675]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[676]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[110]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[677]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[678]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[679]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[680]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[681]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[478]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[682]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[683]

Drug(s) Affected By Retinoblastoma-associated protein (RB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[684]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[685]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[417]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[475]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[108]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[302]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[339]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[686]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[123]

Drug(s) Affected By Alpha-enolase (ENO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[687]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[309]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[688]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[689]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[115]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[87]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[690]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[433]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[79]

Drug(s) Affected By Cathepsin D (CTSD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[691]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[434]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[103]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[692]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[693]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[81]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[40]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]

Drug(s) Affected By Heat shock protein HSP 90-alpha (HSP90AA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[356]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[364]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[196]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[694]
Selenium	DM25CGV	N. A.	N. A.	Approved	[47]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[695]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[146]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[696]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]

Drug(s) Affected By 72 kDa type IV collagenase (MMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[665]
Selenium	DM25CGV	N. A.	N. A.	Approved	[650]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[697]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[698]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[699]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[349]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[652]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[653]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[700]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[294]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[701]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[371]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[597]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[702]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[455]
Selenium	DM25CGV	N. A.	N. A.	Approved	[703]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[704]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[705]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[122]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[406]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[706]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[707]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[480]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[708]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[477]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[708]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[709]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[710]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[711]

Drug(s) Affected By Heat shock 70 kDa protein 1A (HSPA1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[712]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[701]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[99]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[694]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[274]
Selenium	DM25CGV	N. A.	N. A.	Approved	[47]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[309]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[110]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[187]

Drug(s) Affected By 60 kDa heat shock protein, mitochondrial (HSPD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[206]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[309]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[207]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[713]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[187]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[157]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[714]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[87]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[715]

Drug(s) Affected By Endoplasmic reticulum chaperone BiP (HSPA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[264]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[716]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[717]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[309]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[718]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[719]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[720]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[721]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[722]

Drug(s) Affected By Lysosome-associated membrane glycoprotein 1 (LAMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[18]
Selenium	DM25CGV	N. A.	N. A.	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[57]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[633]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[723]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[724]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[18]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[725]

Drug(s) Affected By Pyruvate kinase PKM (PKM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[726]
Selenium	DM25CGV	N. A.	N. A.	Approved	[47]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[727]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[438]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[76]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[281]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[442]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[728]

Drug(s) Affected By Histone H2AX (H2AX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[729]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[730]
Selenium	DM25CGV	N. A.	N. A.	Approved	[47]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[731]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[732]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[733]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[734]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[735]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[208]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[736]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-3 (ATF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[701]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[274]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[228]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[737]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[303]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[738]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[87]

Drug(s) Affected By ATP synthase subunit alpha, mitochondrial (ATP5F1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[18]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[739]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[740]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[741]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[742]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[743]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[728]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[744]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[345]

Drug(s) Affected By Protein disulfide-isomerase A3 (PDIA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[745]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[309]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[571]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[18]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[18]

Drug(s) Affected By G1/S-specific cyclin-D2 (CCND2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[434]
Selenium	DM25CGV	N. A.	N. A.	Approved	[106]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[122]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[123]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[746]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[747]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[748]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[310]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[89]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[50]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[749]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[750]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[478]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[751]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[752]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[753]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[754]
Selenium	DM25CGV	N. A.	N. A.	Approved	[47]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[161]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[107]

Drug(s) Affected By Multidrug resistance-associated protein 1 (ABCC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[755]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[756]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[757]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[758]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[759]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[256]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[760]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[761]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[762]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[762]

Drug(s) Affected By Heat shock 70 kDa protein 1-like (HSPA1L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[712]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[564]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[187]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[188]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[696]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Isoproterenol	DMK7MEY	Atrioventricular block		Approved	[763]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]
Teriflunomide	DMQ2FKJ	Hyperlipidaemia	5C80	Approved	[764]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma (PPARG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[765]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[655]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[766]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[767]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[768]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[769]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[770]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[771]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[772]

Drug(s) Affected By Stress-70 protein, mitochondrial (HSPA9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[50]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[773]
Gallium nitrate	DMF9O6B	Hypercalcaemia	5B91.0	Approved	[774]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[18]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[775]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[748]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[97]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[136]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[776]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[475]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[274]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[621]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[777]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[477]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[338]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[778]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[779]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[780]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[679]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[781]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[782]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[783]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[784]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[785]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[472]

Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[786]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[134]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[787]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[455]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[138]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[291]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[714]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[788]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[138]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[789]

Drug(s) Affected By Mitogen-activated protein kinase 9 (MAPK9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[134]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[138]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[790]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[791]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[138]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[792]
Sorbitol	DMAN0DE	Constipation	DD91.1	Approved	[793]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]

Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[794]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[795]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[406]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[796]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[474]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[797]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[480]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[798]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[520]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[799]

Drug(s) Affected By Triosephosphate isomerase (TPI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[47]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[309]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[688]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[713]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[57]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[743]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[800]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[728]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[50]

Drug(s) Affected By Peroxiredoxin-1 (PRDX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[801]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[309]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[122]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[115]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[187]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[157]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[35]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[432]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[157]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[728]

Drug(s) Affected By Sequestosome-1 (SQSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[289]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[391]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[802]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[726]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[803]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[228]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[122]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[438]

Drug(s) Affected By Dihydropyrimidinase-related protein 2 (DPYSL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[804]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[35]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[728]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[18]

Drug(s) Affected By Scavenger receptor class B member 1 (SCARB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[805]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[806]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[807]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[115]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[57]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[808]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[809]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[810]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[354]

Drug(s) Affected By Sialidase-1 (NEU1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[228]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[811]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[737]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[50]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[55]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[812]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[46]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[216]

Drug(s) Affected By Eukaryotic translation initiation factor 2A (EIF2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[813]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[814]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[815]
Cerulenin	DM6N4PR	Weight loss	MG43.5	Approved	[816]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[433]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[447]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]

Drug(s) Affected By Autophagy protein 5 (ATG5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[392]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[817]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[633]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[818]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[819]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[635]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[820]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[471]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]

Drug(s) Affected By Tumor protein 63 (TP63)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[49]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[821]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[319]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[822]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[823]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[824]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]

Drug(s) Affected By D-3-phosphoglycerate dehydrogenase (PHGDH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[182]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[182]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[79]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]

Drug(s) Affected By Actin, cytoplasmic 1 (ACTB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Selenium	DM25CGV	N. A.	N. A.	Approved	[47]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[309]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[825]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[35]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[28]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]

Drug(s) Affected By Dynein light chain Tctex-type 3 (DYNLT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[55]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[44]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[232]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[48]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[493]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[151]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[826]

Drug(s) Affected By Signal recognition particle 9 kDa protein (SRP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[827]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[67]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[48]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[150]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[828]

Drug(s) Affected By Aldehyde dehydrogenase family 3 member B1 (ALDH3B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[197]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[89]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[34]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[268]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[217]

Drug(s) Affected By Leucine-rich repeat-containing protein 59 (LRRC59)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[124]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[50]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[604]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[498]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[143]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[150]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[36]

Drug(s) Affected By Glutathione S-transferase A1 (GSTA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Artemisinin	DMOY7W3	Malaria	1F40-1F45	Approved	[829]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[830]
Thiotepa	DMIZKOP	Breast cancer	2C60-2C65	Approved	[831]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[832]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[833]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[834]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[835]
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[836]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[19]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[207]

Drug(s) Affected By Aldehyde dehydrogenase, dimeric NADP-preferring (ALDH3A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[837]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[303]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[838]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[839]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[77]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[354]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[34]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]

Drug(s) Affected By Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (SAMHD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[50]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[345]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[256]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[55]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[114]

Drug(s) Affected By RalA-binding protein 1 (RALBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[49]
Selenium	DM25CGV	N. A.	N. A.	Approved	[47]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[236]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[840]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[841]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[143]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[67]

Drug(s) Affected By Alpha-actinin-4 (ACTN4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[47]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[842]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[444]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[34]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[498]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[47]

Drug(s) Affected By Aldehyde dehydrogenase 1A1 (ALDH1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[19]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[843]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[213]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[839]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[152]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[236]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[844]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[845]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[846]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[558]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[50]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[34]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[216]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[542]
LY294002	DMY1AFS	Neuroblastoma	2D11.2	Phase 1	[846]

Drug(s) Affected By F-actin-capping protein subunit beta (CAPZB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[847]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[50]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[355]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[34]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[255]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[143]

Drug(s) Affected By Glutathione S-transferase Mu 2 (GSTM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[197]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[88]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[88]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[34]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[848]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[849]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[850]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[46]

Drug(s) Affected By Carbonic anhydrase 2 (CA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetazolamide	DM1AF5U	Absence epilepsy		Approved	[851]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[852]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[675]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[152]
Methazolamide	DM7J2TA	Glaucoma/ocular hypertension	9C61	Approved	[853]
Topiramate	DM82Z30	Alcohol dependence	6C40.2	Approved	[854]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[41]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[855]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]

Drug(s) Affected By Transcription factor EB (TFEB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[47]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[856]
Prochlorperazine	DM53SRA	Nausea	MD90	Approved	[856]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[633]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[723]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[89]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[50]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[156]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[55]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[66]

Drug(s) Affected By Aldehyde dehydrogenase, mitochondrial (ALDH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[857]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[152]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[432]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[858]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[859]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[50]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]

Drug(s) Affected By Glutathione S-transferase P (GSTP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[860]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[861]
Chlorambucil	DMRKE63	Chronic lymphocytic leukaemia	2A82.0	Approved	[861]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[862]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[273]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Selenium	DM25CGV	N. A.	N. A.	Approved	[47]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[309]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[863]

Drug(s) Affected By Ceruloplasmin (CP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[864]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[35]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[865]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[866]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[28]

Drug(s) Affected By Aldo-keto reductase family 1 member B10 (AKR1B10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[539]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[275]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[51]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[867]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[544]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[77]
Reserpine	DM6VM38	Hypertension	BA00-BA04	Approved	[868]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[89]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[316]

Drug(s) Affected By Aldo-keto reductase family 1 member B1 (AKR1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[260]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[869]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[316]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[158]
Benzoic Acid	DMKB9FI	Alopecia areata	ED70.2	Approved	[316]

Drug(s) Affected By Cofilin-1 (CFL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[434]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[309]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[689]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[571]
Haloperidol	DM96SE0	Delirium		Approved	[18]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[728]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[444]

Drug(s) Affected By Alpha-actinin-1 (ACTN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[47]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[257]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[444]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[313]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[46]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[24]

Drug(s) Affected By Alpha-aminoadipic semialdehyde dehydrogenase (ALDH7A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[84]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[728]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[34]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[155]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[38]

Drug(s) Affected By Fructose-bisphosphate aldolase A (ALDOA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[47]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[309]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[688]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[689]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[115]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[438]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[125]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[81]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[79]

Drug(s) Affected By Adenylyl cyclase-associated protein 1 (CAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[50]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[34]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[216]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[28]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[827]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[47]

Drug(s) Affected By Glutathione S-transferase A4 (GSTA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[112]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[50]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[201]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[34]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[849]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[112]

Drug(s) Affected By Aldo-keto reductase family 1 member A1 (AKR1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[870]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[232]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[158]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[27]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[232]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[870]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[67]

Drug(s) Affected By SERPINE1 mRNA-binding protein 1 (SERBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[50]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[55]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[19]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Inhibitor of nuclear factor kappa-B kinase (IKK)	TTRPDBG	NOUNIPROTAC	Inhibitor	[2]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
NADPH:quinone reductase (CRYZ) Main DME	DE8RYV5	QOR_HUMAN	Substrate	[3]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
14-3-3 protein eta	OTP8NJFJ	1433F_HUMAN	Gene/Protein Processing	[4]
5-hydroxymethyl-dUMP N-hydrolase (DNPH1)	OTEZVTI1	DNPH1_HUMAN	Gene/Protein Processing	[4]
60 kDa heat shock protein, mitochondrial (HSPD1)	OTTO1Y11	CH60_HUMAN	Protein Interaction/Cellular Processes	[5]
72 kDa type IV collagenase (MMP2)	OT5NIWA2	MMP2_HUMAN	Gene/Protein Processing	[6]
Actin, cytoplasmic 1 (ACTB)	OT1MCP2F	ACTB_HUMAN	Drug Response	[7]
Adenomatous polyposis coli protein (APC)	OTKV0TIK	APC_HUMAN	Gene/Protein Processing	[4]
Adenosine 5'-monophosphoramidase HINT1 (HINT1)	OTQIR8LF	HINT1_HUMAN	Gene/Protein Processing	[4]
Adenosine receptor A1 (ADORA1)	OTI7X39E	AA1R_HUMAN	Gene/Protein Processing	[4]
Adenylyl cyclase-associated protein 1 (CAP1)	OTYM8A2N	CAP1_HUMAN	Drug Response	[7]
Aflatoxin B1 aldehyde reductase member 2 (AKR7A2)	OTGEDDM2	ARK72_HUMAN	Gene/Protein Processing	[8]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6274).
• [2] IkappaB kinase, a molecular target for inhibition by 4-hydroxy-2-nonenal. J Biol Chem. 2001 May 25;276(21):18223-8.
• [3] Kinetic and structural evidence of the alkenal/one reductase specificity of human crystallin. Cell Mol Life Sci. 2011 Mar;68(6):1065-77.
• [4] Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells. Free Radic Biol Med. 2002 Nov 15;33(10):1419-32.
• [5] Identification of protein targets of 4-hydroxynonenal using click chemistry for ex vivo biotinylation of azido and alkynyl derivatives. Chem Res Toxicol. 2008 Feb;21(2):432-44. doi: 10.1021/tx700347w. Epub 2008 Jan 31.
• [6] 4-Hydroxynonenal as a selective pro-fibrogenic stimulus for activated human hepatic stellate cells. J Hepatol. 2004 Jan;40(1):60-8. doi: 10.1016/s0168-8278(03)00480-x.
• [7] Site-specific protein adducts of 4-hydroxy-2(E)-nonenal in human THP-1 monocytic cells: protein carbonylation is diminished by ascorbic acid. Chem Res Toxicol. 2010 Jan;23(1):37-47. doi: 10.1021/tx9002462.
• [8] Protective effect of inducible aldo-keto reductases on 4-hydroxynonenal- induced hepatotoxicity. Chem Biol Interact. 2019 May 1;304:124-130.
• [9] Novel NF-B inhibitors: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):319-34.
• [10] Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKepsilon kinases. Bioorg Med Chem Lett. 2012 Dec 1;22(23):7169-73.
• [11] Inhibition of NF-kappa B activation by arsenite through reaction with a critical cysteine in the activation loop of Ikappa B kinase. J Biol Chem. 2000 Nov 17;275(46):36062-6.
• [12] Novel IKK inhibitors: beta-carbolines. Bioorg Med Chem Lett. 2003 Jul 21;13(14):2419-22.
• [13] Novel cross-talk within the IKK family controls innate immunity. Biochem J. 2011 Feb 15;434(1):93-104.
• [14] Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127.
• [15] A highly selective inhibitor of I kappa B kinase, BMS-345541, blocks both joint inflammation and destruction in collagen-induced arthritis in mice. Arthritis Rheum. 2003 Sep;48(9):2652-9.
• [16] Role of glutathione reductase during menadione-induced NADPH oxidation in isolated rat hepatocytes. Biochem Pharmacol. 1987 Nov 15;36(22):3879-84.
• [17] Effect of superoxide dismutase on the autoxidation of various hydroquinones--a possible role of superoxide dismutase as a superoxide:semiquinone oxidoreductase. Free Radic Biol Med. 1988;5(2):71-9.
• [18] Cannabidiol Displays Proteomic Similarities to Antipsychotics in Cuprizone-Exposed Human Oligodendrocytic Cell Line MO3.13. Front Mol Neurosci. 2021 May 28;14:673144. doi: 10.3389/fnmol.2021.673144. eCollection 2021.
• [19] Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
• [20] Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
• [21] Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
• [22] Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
• [23] Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
• [24] Gene expression analysis of precision-cut human liver slices indicates stable expression of ADME-Tox related genes. Toxicol Appl Pharmacol. 2011 May 15;253(1):57-69.
• [25] Apoptosis, cell cycle progression and gene expression in TP53-depleted HCT116 colon cancer cells in response to short-term 5-fluorouracil treatment. Int J Oncol. 2007 Dec;31(6):1491-500.
• [26] Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
• [27] Reproducible chemical-induced changes in gene expression profiles in human hepatoma HepaRG cells under various experimental conditions. Toxicol In Vitro. 2009 Apr;23(3):466-75. doi: 10.1016/j.tiv.2008.12.018. Epub 2008 Dec 30.
• [28] Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
• [29] Arsenic trioxide induces different gene expression profiles of genes related to growth and apoptosis in glioma cells dependent on the p53 status. Mol Biol Rep. 2008 Sep;35(3):421-9.
• [30] Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
• [31] Repurposing L-menthol for systems medicine and cancer therapeutics? L-menthol induces apoptosis through caspase 10 and by suppressing HSP90. OMICS. 2016 Jan;20(1):53-64.
• [32] [Mechanisms of capsaicin-induced apoptosis of human melanoma A375-S2 cells]. Zhonghua Zhong Liu Za Zhi. 2005 Jul;27(7):401-3.
• [33] The proapoptotic effect of zoledronic acid is independent of either the bone microenvironment or the intrinsic resistance to bortezomib of myeloma cells and is enhanced by the combination with arsenic trioxide. Exp Hematol. 2011 Jan;39(1):55-65.
• [34] Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
• [35] Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
• [36] Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
• [37] Drug-induced endoplasmic reticulum and oxidative stress responses independently sensitize toward TNF-mediated hepatotoxicity. Toxicol Sci. 2014 Jul;140(1):144-59. doi: 10.1093/toxsci/kfu072. Epub 2014 Apr 20.
• [38] Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
• [39] Changes in gene expressions elicited by physiological concentrations of genistein on human endometrial cancer cells. Mol Carcinog. 2006 Oct;45(10):752-63.
• [40] The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
• [41] Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol. 2005 Nov;19(11):2685-95.
• [42] Identification of biomarkers and outcomes of endocrine disruption in human ovarian cortex using In Vitro Models. Toxicology. 2023 Feb;485:153425. doi: 10.1016/j.tox.2023.153425. Epub 2023 Jan 5.
• [43] Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
• [44] Epidermal growth factor receptor signalling in human breast cancer cells operates parallel to estrogen receptor alpha signalling and results in tamoxifen insensitive proliferation. BMC Cancer. 2014 Apr 23;14:283.
• [45] COVID-19: combining antiviral and anti-inflammatory treatments. Lancet Infect Dis. 2020 Apr;20(4):400-402. doi: 10.1016/S1473-3099(20)30132-8. Epub 2020 Feb 27.
• [46] Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Toxicol Sci. 2015 Jan;143(1):97-106. doi: 10.1093/toxsci/kfu210. Epub 2014 Oct 10.
• [47] Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
• [48] Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
• [49] DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.
• [50] Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
• [51] Transcriptomic analysis of untreated and drug-treated differentiated HepaRG cells over a 2-week period. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):27-35.
• [52] Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
• [53] Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation. Blood. 2005 Jul 1;106(1):304-10.
• [54] Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
• [55] Low doses of cisplatin induce gene alterations, cell cycle arrest, and apoptosis in human promyelocytic leukemia cells. Biomark Insights. 2016 Aug 24;11:113-21.
• [56] Bromodomain-containing protein 4 (BRD4) regulates RNA polymerase II serine 2 phosphorylation in human CD4+ T cells. J Biol Chem. 2012 Dec 14;287(51):43137-55.
• [57] Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
• [58] Dasatinib reverses cancer-associated fibroblasts (CAFs) from primary lung carcinomas to a phenotype comparable to that of normal fibroblasts. Mol Cancer. 2010 Jun 27;9:168.
• [59] Transcriptional profiling of testosterone-regulated genes in the skeletal muscle of human immunodeficiency virus-infected men experiencing weight loss. J Clin Endocrinol Metab. 2007 Jul;92(7):2793-802. doi: 10.1210/jc.2006-2722. Epub 2007 Apr 17.
• [60] Distinctive profiles of gene expression in the human nucleus accumbens associated with cocaine and heroin abuse. Neuropsychopharmacology. 2006 Oct;31(10):2304-12. doi: 10.1038/sj.npp.1301089. Epub 2006 May 3.
• [61] The use of genomics technology to investigate gene expression changes in cultured human liver cells. Toxicol In Vitro. 2001 Aug-Oct;15(4-5):399-405. doi: 10.1016/s0887-2333(01)00043-1.
• [62] Analysis of gene expression induced by diethylstilbestrol (DES) in human primitive Mullerian duct cells using microarray. Cancer Lett. 2005 Apr 8;220(2):197-210.
• [63] Cdk9 regulates neural differentiation and its expression correlates with the differentiation grade of neuroblastoma and PNET tumors. Cancer Biol Ther. 2005 Mar;4(3):277-81. doi: 10.4161/cbt.4.3.1497. Epub 2005 Mar 20.
• [64] Identification by automated screening of a small molecule that selectively eliminates neural stem cells derived from hESCs but not dopamine neurons. PLoS One. 2009 Sep 23;4(9):e7155.
• [65] Genistein and bisphenol A exposure cause estrogen receptor 1 to bind thousands of sites in a cell type-specific manner. Genome Res. 2012 Nov;22(11):2153-62.
• [66] Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
• [67] Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.
• [68] Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May;1(3):177-87.
• [69] Epigenetic activation of O-linked -N-acetylglucosamine transferase overrides the differentiation blockage in acute leukemia. EBioMedicine. 2020 Apr;54:102678. doi: 10.1016/j.ebiom.2020.102678. Epub 2020 Apr 6.
• [70] Bisbenzamidine derivative, pentamidine represses DNA damage response through inhibition of histone H2A acetylation. Mol Cancer. 2010 Feb 9;9:34. doi: 10.1186/1476-4598-9-34.
• [71] DNA methylation inhibitor 5-Aza-2'-deoxycytidine induces reversible genome-wide DNA damage that is distinctly influenced by DNA methyltransferases 1 and 3B. Mol Cell Biol. 2008 Jan;28(2):752-71. doi: 10.1128/MCB.01799-07. Epub 2007 Nov 8.
• [72] Quercetin and Its Fermented Extract as a Potential Inhibitor of Bisphenol A-Exposed HT-29 Colon Cancer Cells' Viability. Int J Mol Sci. 2023 Mar 15;24(6):5604. doi: 10.3390/ijms24065604.
• [73] Fermentation Extract of Naringenin Increases the Expression of Estrogenic Receptor and Modulates Genes Related to the p53 Signalling Pathway, miR-200c and miR-141 in Human Colon Cancer Cells Exposed to BPA. Molecules. 2022 Oct 5;27(19):6588. doi: 10.3390/molecules27196588.
• [74] Effects of ciglitazone and troglitazone on the proliferation of human stomach cancer cells. World J Gastroenterol. 2009 Jan 21;15(3):310-20.
• [75] Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
• [76] A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
• [77] Keratinocyte-derived IL-36gama plays a role in hydroquinone-induced chemical leukoderma through inhibition of melanogenesis in human epidermal melanocytes. Arch Toxicol. 2019 Aug;93(8):2307-2320.
• [78] Single-cell Transcriptome Mapping Identifies Common and Cell-type Specific Genes Affected by Acute Delta9-tetrahydrocannabinol in Humans. Sci Rep. 2020 Feb 26;10(1):3450. doi: 10.1038/s41598-020-59827-1.
• [79] Transcriptomics hit the target: monitoring of ligand-activated and stress response pathways for chemical testing. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):7-18.
• [80] Synergistic activity of BET protein antagonist-based combinations in mantle cell lymphoma cells sensitive or resistant to ibrutinib. Blood. 2015 Sep 24;126(13):1565-74.
• [81] Genomic and proteomic analysis of the effects of cannabinoids on normal human astrocytes. Brain Res. 2008 Jan 29;1191:1-11.
• [82] Mechanism of cisplatin proximal tubule toxicity revealed by integrating transcriptomics, proteomics, metabolomics and biokinetics. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):117-27.
• [83] Quantitative phosphoproteomics reveal cellular responses from caffeine, coumarin and quercetin in treated HepG2 cells. Toxicol Appl Pharmacol. 2022 Aug 15;449:116110. doi: 10.1016/j.taap.2022.116110. Epub 2022 Jun 7.
• [84] Identification of transcriptome signatures and biomarkers specific for potential developmental toxicants inhibiting human neural crest cell migration. Arch Toxicol. 2016 Jan;90(1):159-80.
• [85] Detection of differentially expressed genes in human colon carcinoma cells treated with a selective COX-2 inhibitor. Oncogene. 2001 Jul 27;20(33):4450-6. doi: 10.1038/sj.onc.1204588.
• [86] Sulindac activates nuclear translocation of AIF, DFF40 and endonuclease G but not induces oligonucleosomal DNA fragmentation in HT-29 cells. Life Sci. 2005 Sep 2;77(16):2059-70. doi: 10.1016/j.lfs.2005.04.021.
• [87] Motexafin gadolinium and zinc induce oxidative stress responses and apoptosis in B-cell lymphoma lines. Cancer Res. 2005 Dec 15;65(24):11676-88.
• [88] Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
• [89] Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
• [90] Design principles of concentration-dependent transcriptome deviations in drug-exposed differentiating stem cells. Chem Res Toxicol. 2014 Mar 17;27(3):408-20.
• [91] Exposure to nerve growth factor worsens nephrotoxic effect induced by Cyclosporine A in HK-2 cells. PLoS One. 2013 Nov 7;8(11):e80113. doi: 10.1371/journal.pone.0080113. eCollection 2013.
• [92] Nuclear and Mitochondrial DNA Methylation Patterns Induced by Valproic Acid in Human Hepatocytes. Chem Res Toxicol. 2017 Oct 16;30(10):1847-1854. doi: 10.1021/acs.chemrestox.7b00171. Epub 2017 Sep 13.
• [93] Decitabine up-regulates S100A2 expression and synergizes with IFN-gamma to kill uveal melanoma cells. Clin Cancer Res. 2007 Sep 1;13(17):5219-25. doi: 10.1158/1078-0432.CCR-07-0816.
• [94] Hydroxychloroquine inhibits CD154 expression in CD4(+) T lymphocytes of systemic lupus erythematosus through NFAT, but not STAT5, signaling. Arthritis Res Ther. 2017 Aug 9;19(1):183. doi: 10.1186/s13075-017-1393-y.
• [95] The effect of DNA methylation inhibitor 5-Aza-2'-deoxycytidine on human endometrial stromal cells. Hum Reprod. 2010 Nov;25(11):2859-69.
• [96] Transcriptomics and methylomics of CD4-positive T cells in arsenic-exposed women. Arch Toxicol. 2017 May;91(5):2067-2078. doi: 10.1007/s00204-016-1879-4. Epub 2016 Nov 12.
• [97] Cannabidiol Activates Neuronal Precursor Genes in Human Gingival Mesenchymal Stromal Cells. J Cell Biochem. 2017 Jun;118(6):1531-1546. doi: 10.1002/jcb.25815. Epub 2016 Dec 29.
• [98] Selection of drugs to test the specificity of the Tg.AC assay by screening for induction of the gadd153 promoter in vitro. Toxicol Sci. 2003 Aug;74(2):260-70. doi: 10.1093/toxsci/kfg113. Epub 2003 May 2.
• [99] Sertraline induces endoplasmic reticulum stress in hepatic cells. Toxicology. 2014 Aug 1;322:78-88. doi: 10.1016/j.tox.2014.05.007. Epub 2014 May 24.
• [100] Estrogen regulation in human breast cancer cells of new downstream gene targets involved in estrogen metabolism, cell proliferation and cell transformation. J Mol Endocrinol. 2004 Apr;32(2):397-414.
• [101] Methotrexate induces production of IL-1 and IL-6 in the monocytic cell line U937. Arthritis Res Ther. 2014 Jan 20;16(1):R17. doi: 10.1186/ar4444.
• [102] Simvastatin inhibits NOR-1 expression induced by hyperlipemia by interfering with CREB activation. Cardiovasc Res. 2005 Aug 1;67(2):333-41. doi: 10.1016/j.cardiores.2005.03.016. Epub 2005 Apr 21.
• [103] The G protein-coupled receptor GPR30 mediates c-fos up-regulation by 17beta-estradiol and phytoestrogens in breast cancer cells. J Biol Chem. 2004 Jun 25;279(26):27008-16. doi: 10.1074/jbc.M403588200. Epub 2004 Apr 16.
• [104] Acetaminophen-induced proliferation of estrogen-responsive breast cancer cells is associated with increases in c-myc RNA expression and NF-kappaB activity. Toxicol Sci. 2002 Apr;66(2):233-43. doi: 10.1093/toxsci/66.2.233.
• [105] ZD1839 induces p15INK4b and causes G1 arrest by inhibiting the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway. Mol Cancer Ther. 2007 May;6(5):1579-87. doi: 10.1158/1535-7163.MCT-06-0814.
• [106] Selenite and selenomethionine promote HL-60 cell cycle progression. J Nutr. 2002 Apr;132(4):674-9. doi: 10.1093/jn/132.4.674.
• [107] Ribavirin augments doxorubicin's efficacy in human hepatocellular carcinoma through inhibiting doxorubicin-induced eIF4E activation. J Biochem Mol Toxicol. 2018 Jan;32(1). doi: 10.1002/jbt.22007. Epub 2017 Nov 7.
• [108] Combination small molecule MEK and PI3K inhibition enhances uveal melanoma cell death in a mutant GNAQ- and GNA11-dependent manner. Clin Cancer Res. 2012 Aug 15;18(16):4345-55. doi: 10.1158/1078-0432.CCR-11-3227. Epub 2012 Jun 25.
• [109] Novel detection and differential utilization of a c-myc transcriptional block in colon cancer chemoprevention. Cancer Res. 2002 Nov 1;62(21):6006-10.
• [110] The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
• [111] The role of acetaldehyde in mediating effects of alcohol on expression of endogenous opioid system genes in a neuroblastoma cell line. FASEB J. 2008 Mar;22(3):662-70. doi: 10.1096/fj.07-8346com. Epub 2007 Oct 12.
• [112] Acute hypersensitivity of pluripotent testicular cancer-derived embryonal carcinoma to low-dose 5-aza deoxycytidine is associated with global DNA Damage-associated p53 activation, anti-pluripotency and DNA demethylation. PLoS One. 2012;7(12):e53003. doi: 10.1371/journal.pone.0053003. Epub 2012 Dec 27.
• [113] Gene expression profile of the nucleus accumbens of human cocaine abusers: evidence for dysregulation of myelin. J Neurochem. 2004 Mar;88(5):1211-9. doi: 10.1046/j.1471-4159.2003.02247.x.
• [114] Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen. Clin Pharmacol Ther. 2016 Apr;99(4):432-41.
• [115] Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
• [116] Nevirapine increases high-density lipoprotein cholesterol concentration by stimulation of apolipoprotein A-I production. Arterioscler Thromb Vasc Biol. 2009 Sep;29(9):1336-41. doi: 10.1161/ATVBAHA.109.192088. Epub 2009 Aug 10.
• [117] Computational discovery of niclosamide ethanolamine, a repurposed drug candidate that reduces growth of hepatocellular carcinoma cells initro and in mice by inhibiting cell division cycle 37 signaling. Gastroenterology. 2017 Jun;152(8):2022-2036.
• [118] ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
• [119] Cannabidiol and Oxygen-Ozone Combination Induce Cytotoxicity in Human Pancreatic Ductal Adenocarcinoma Cell Lines. Cancers (Basel). 2020 Sep 27;12(10):2774. doi: 10.3390/cancers12102774.
• [120] Down-regulation of HER-2 expression in human breast cancer cell HBC-4 and ZR75-1 by nitrogen-mustard-N-oxide. Kobe J Med Sci. 2007;53(4):135-42.
• [121] Epidermal growth factor receptor activity determines response of colorectal cancer cells to gefitinib alone and in combination with chemotherapy. Clin Cancer Res. 2005 Oct 15;11(20):7480-9. doi: 10.1158/1078-0432.CCR-05-0328.
• [122] Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells. Tumour Biol. 2011 Oct;32(5):965-76.
• [123] Inhibition of prostate cancer cell colony formation by the flavonoid quercetin correlates with modulation of specific regulatory genes. Clin Diagn Lab Immunol. 2004 Jan;11(1):63-9. doi: 10.1128/cdli.11.1.63-69.2004.
• [124] Proteomics-based identification of differentially abundant proteins from human keratinocytes exposed to arsenic trioxide. J Proteomics Bioinform. 2014 Jul;7(7):166-178.
• [125] Expression profile analysis of human peripheral blood mononuclear cells in response to aspirin. Arch Immunol Ther Exp (Warsz). 2005 Mar-Apr;53(2):151-8.
• [126] MiR-99a and MiR-491 Regulate Cisplatin Resistance in Human Gastric Cancer Cells by Targeting CAPNS1. Int J Biol Sci. 2016 Nov 5;12(12):1437-1447. doi: 10.7150/ijbs.16529. eCollection 2016.
• [127] Simvastatin protects neurons from cytotoxicity by up-regulating Bcl-2 mRNA and protein. J Neurochem. 2007 Apr;101(1):77-86. doi: 10.1111/j.1471-4159.2006.04375.x. Epub 2007 Jan 4.
• [128] Chelation and intercalation: complementary properties in a compound for the treatment of Alzheimer's disease. J Struct Biol. 2000 Jun;130(2-3):209-16. doi: 10.1006/jsbi.2000.4285.
• [129] Increased processing of APLP2 and APP with concomitant formation of APP intracellular domains in BDNF and retinoic acid-differentiated human neuroblastoma cells. J Neurochem. 2005 Nov;95(4):1059-68. doi: 10.1111/j.1471-4159.2005.03440.x. Epub 2005 Sep 7.
• [130] Comparison of base-line and chemical-induced transcriptomic responses in HepaRG and RPTEC/TERT1 cells using TempO-Seq. Arch Toxicol. 2018 Aug;92(8):2517-2531.
• [131] Synergistic effects of iron and aluminum on stress-related gene expression in primary human neural cells. J Alzheimers Dis. 2005 Nov;8(2):117-27; discussion 209-15. doi: 10.3233/jad-2005-8204.
• [132] High-dose mitoxantrone induces programmed cell death or apoptosis in human myeloid leukemia cells. Blood. 1993 Nov 15;82(10):3133-40.
• [133] Gene expression data from acetaminophen-induced toxicity in human hepatic in vitro systems and clinical liver samples. Data Brief. 2016 Mar 26;7:1052-1057. doi: 10.1016/j.dib.2016.03.069. eCollection 2016 Jun.
• [134] Inhibition of autophagic flux differently modulates cannabidiol-induced death in 2D and 3D glioblastoma cell cultures. Sci Rep. 2020 Feb 14;10(1):2687. doi: 10.1038/s41598-020-59468-4.
• [135] Nitrogen mustard prevents transport of Fra-1 into the nucleus to promote c-Fos- and FosB-dependent IL-8 induction in injured mouse epidermis. Toxicol Lett. 2020 Feb 1;319:256-263. doi: 10.1016/j.toxlet.2019.10.006. Epub 2019 Oct 19.
• [136] Gene expression profiles with activation of the estrogen receptor alpha-selective estrogen receptor modulator complex in breast cancer cells expressing wild-type estrogen receptor. Cancer Res. 2002 Aug 1;62(15):4419-26.
• [137] Oxidative stress modulates theophylline effects on steroid responsiveness. Biochem Biophys Res Commun. 2008 Dec 19;377(3):797-802.
• [138] Nocodazole-induced p53-dependent c-Jun N-terminal kinase activation reduces apoptosis in human colon carcinoma HCT116 cells. J Biol Chem. 2002 Nov 15;277(46):43648-58. doi: 10.1074/jbc.M203214200. Epub 2002 Sep 6.
• [139] [Regulation mechanism of autophagy-related protein LC3 by c-Jun in methotrexate resistant human choriocarcinoma JEG-3 cells]. Zhonghua Fu Chan Ke Za Zhi. 2014 Jul;49(7):531-5.
• [140] Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis. Biochem Pharmacol. 2004 Dec 1;68(11):2177-86.
• [141] Structure based drug design of crizotinib (PF-02341066), a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK). J Med Chem. 2011 Sep 22;54(18):6342-63. doi: 10.1021/jm2007613. Epub 2011 Aug 18.
• [142] Imatinib mesylate inhibits T-cell proliferation in vitro and delayed-type hypersensitivity in vivo. Blood. 2004 Aug 15;104(4):1094-9. doi: 10.1182/blood-2003-12-4266. Epub 2004 Apr 20.
• [143] LSD1 activates a lethal prostate cancer gene network independently of its demethylase function. Proc Natl Acad Sci U S A. 2018 May 1;115(18):E4179-E4188.
• [144] Sorafenib induces cell death in chronic lymphocytic leukemia by translational downregulation of Mcl-1. Leukemia. 2011 May;25(5):838-47. doi: 10.1038/leu.2011.2. Epub 2011 Feb 4.
• [145] Molecular mechanism of action of bisphenol and bisphenol A mediated by oestrogen receptor alpha in growth and apoptosis of breast cancer cells. Br J Pharmacol. 2013 May;169(1):167-78.
• [146] Quantitative proteomic analysis of HepG2 cells treated with quercetin suggests IQGAP1 involved in quercetin-induced regulation of cell proliferation and migration. OMICS. 2009 Apr;13(2):93-103. doi: 10.1089/omi.2008.0075.
• [147] Curcumin prevents DNA damage and enhances the repair potential in a chronically arsenic-exposed human population in West Bengal, India. Eur J Cancer Prev. 2011 Mar;20(2):123-31. doi: 10.1097/cej.0b013e328341017a.
• [148] The role of base excision repair in the sensitivity and resistance to temozolomide-mediated cell death. Cancer Res. 2005 Jul 15;65(14):6394-400. doi: 10.1158/0008-5472.CAN-05-0715.
• [149] Activation of ATM/Chk1 by curcumin causes cell cycle arrest and apoptosis in human pancreatic cancer cells. Br J Cancer. 2009 May 5;100(9):1425-33. doi: 10.1038/sj.bjc.6605039.
• [150] Bisphenol A induces DSB-ATM-p53 signaling leading to cell cycle arrest, senescence, autophagy, stress response, and estrogen release in human fetal lung fibroblasts. Arch Toxicol. 2018 Apr;92(4):1453-1469.
• [151] A trichostatin A expression signature identified by TempO-Seq targeted whole transcriptome profiling. PLoS One. 2017 May 25;12(5):e0178302. doi: 10.1371/journal.pone.0178302. eCollection 2017.
• [152] Comparative gene expression analysis of a chronic myelogenous leukemia cell line resistant to cyclophosphamide using oligonucleotide arrays and response to tyrosine kinase inhibitors. Leuk Res. 2007 Nov;31(11):1511-20.
• [153] Phenytoin and cyclosporin A suppress the expression of MMP-1, TIMP-1, and cathepsin L, but not cathepsin B in cultured gingival fibroblasts. J Periodontol. 2000 Jun;71(6):955-60. doi: 10.1902/jop.2000.71.6.955.
• [154] The antimalarial amodiaquine causes autophagic-lysosomal and proliferative blockade sensitizing human melanoma cells to starvation- and chemotherapy-induced cell death. Autophagy. 2013 Dec;9(12):2087-102. doi: 10.4161/auto.26506. Epub 2013 Oct 8.
• [155] A transcriptomics-based in vitro assay for predicting chemical genotoxicity in vivo. Carcinogenesis. 2012 Jul;33(7):1421-9.
• [156] A role for the autophagy regulator Transcription Factor EB in amiodarone-induced phospholipidosis. Biochem Pharmacol. 2015 Jun 1;95(3):201-9. doi: 10.1016/j.bcp.2015.03.017. Epub 2015 Apr 13.
• [157] Comparison of the gene expression profiles of monocytic versus granulocytic lineages of HL-60 leukemia cell differentiation by DNA microarray analysis. Life Sci. 2003 Aug 15;73(13):1705-19. doi: 10.1016/s0024-3205(03)00515-0.
• [158] Interleukin-19 as a translational indicator of renal injury. Arch Toxicol. 2015 Jan;89(1):101-6.
• [159] Estrogen utilization of IGF-1-R and EGF-R to signal in breast cancer cells. J Steroid Biochem Mol Biol. 2010 Feb 28;118(4-5):219-30. doi: 10.1016/j.jsbmb.2009.09.018. Epub 2009 Oct 6.
• [160] Implication of the insulin-like growth factor-IR pathway in the resistance of non-small cell lung cancer cells to treatment with gefitinib. Clin Cancer Res. 2007 May 1;13(9):2795-803. doi: 10.1158/1078-0432.CCR-06-2077.
• [161] Low-expressional IGF1 mediated methimazole-induced liver developmental toxicity in fetal mice. Toxicology. 2018 Sep 1;408:70-79. doi: 10.1016/j.tox.2018.07.004. Epub 2018 Jul 7.
• [162] Simvastatin inhibits the proliferation of human prostate cancer PC-3 cells via down-regulation of the insulin-like growth factor 1 receptor. Biochem Biophys Res Commun. 2008 Jul 25;372(2):356-61. doi: 10.1016/j.bbrc.2008.05.043. Epub 2008 May 19.
• [163] Multifaceted preventive effects of single agent quercetin on a human prostate adenocarcinoma cell line (PC-3): implications for nutritional transcriptomics and multi-target therapy. Med Oncol. 2011 Dec;28(4):1395-404. doi: 10.1007/s12032-010-9603-3. Epub 2010 Jul 2.
• [164] Arsenic trioxide and cisplatin synergism increase cytotoxicity in human ovarian cancer cells: therapeutic potential for ovarian cancer. Cancer Sci. 2009 Dec;100(12):2459-64.
• [165] Delta9-tetrahydrocannabinol inhibits cytotrophoblast cell proliferation and modulates gene transcription. Mol Hum Reprod. 2006 May;12(5):321-33. doi: 10.1093/molehr/gal036. Epub 2006 Apr 5.
• [166] Effects of all-trans and 9-cis retinoic acid on differentiating human neural stem cells in vitro. Toxicology. 2023 Mar 15;487:153461. doi: 10.1016/j.tox.2023.153461. Epub 2023 Feb 16.
• [167] The induction of cytochrome P450 2E1 by ethanol leads to the loss of synaptic proteins via PPARalpha down-regulation. Toxicology. 2017 Jun 15;385:18-27.
• [168] The antiretroviral nucleoside analogue Abacavir reduces cell growth and promotes differentiation of human medulloblastoma cells. Int J Cancer. 2009 Jul 1;125(1):235-43. doi: 10.1002/ijc.24331.
• [169] Patterns of selective neuronal damage in methamphetamine-user AIDS patients. J Acquir Immune Defic Syndr. 2003 Dec 15;34(5):467-74. doi: 10.1097/00126334-200312150-00004.
• [170] Patterns of some extracellular matrix gene expression are similar in cells from cleft lip-palate patients and in human palatal fibroblasts exposed to diazepam in culture. Toxicology. 2009 Mar 4;257(1-2):10-6. doi: 10.1016/j.tox.2008.12.002. Epub 2008 Dec 9.
• [171] Quercetin induced cell apoptosis and altered gene expression in AGS human gastric cancer cells. Environ Toxicol. 2018 Nov;33(11):1168-1181. doi: 10.1002/tox.22623. Epub 2018 Aug 27.
• [172] Altered oxidative status and integrin expression in cyclosporine A-treated oral epithelial cells. Toxicol Mech Methods. 2015 Feb;25(2):98-104. doi: 10.3109/15376516.2014.990595. Epub 2015 Jan 22.
• [173] Ethanol and acetone stimulate the proliferation of HaCaT keratinocytes: the possible role of alcohol in exacerbating psoriasis. Arch Dermatol Res. 2003 Jun;295(2):56-62. doi: 10.1007/s00403-003-0399-2. Epub 2003 Apr 26.
• [174] Alcohol and Cannabinoids Differentially Affect HIV Infection and Function of Human Monocyte-Derived Dendritic Cells (MDDC). Front Microbiol. 2015 Dec 22;6:1452. doi: 10.3389/fmicb.2015.01452. eCollection 2015.
• [175] Tacrolimus suppressed the production of cytokines involved in atopic dermatitis by direct stimulation of human PBMC system. (Comparison with steroids). Int Immunopharmacol. 2001 Jun;1(6):1219-26. doi: 10.1016/s1567-5769(01)00059-5.
• [176] Effects of theophylline, dexamethasone and salbutamol on cytokine gene expression in human peripheral blood CD4+ T-cells. Eur Respir J. 1999 Nov;14(5):1106-12. doi: 10.1183/09031936.99.14511069.
• [177] Dimethyl Fumarate Therapy Significantly Improves the Responsiveness of T Cells in Multiple Sclerosis Patients for Immunoregulation by Regulatory T Cells. Int J Mol Sci. 2017 Jan 28;18(2):271. doi: 10.3390/ijms18020271.
• [178] In vitro antitumoral effects of the steroid ouabain on human thyroid papillary carcinoma cell lines. Environ Toxicol. 2021 Jul;36(7):1338-1348. doi: 10.1002/tox.23130. Epub 2021 Mar 24.
• [179] From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. Arch Toxicol. 2014 Jul;88(7):1451-68.
• [180] Cell-based and cytokine-directed chemical screen to identify potential anti-multiple myeloma agents. Leuk Res. 2010 Jul;34(7):917-24. doi: 10.1016/j.leukres.2009.12.002. Epub 2010 Feb 8.
• [181] Structural and functional studies on the human hepatic interleukin-6 receptor. Molecular cloning and overexpression in HepG2 cells. Biochem J. 1991 Aug 1;277 ( Pt 3)(Pt 3):659-64. doi: 10.1042/bj2770659.
• [182] Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration. Arthritis Res Ther. 2009;11(1):R15.
• [183] Retinoic acid receptor alpha amplifications and retinoic acid sensitivity in breast cancers. Clin Breast Cancer. 2013 Oct;13(5):401-8.
• [184] THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders. Transl Psychiatry. 2018 Apr 25;8(1):89. doi: 10.1038/s41398-018-0137-3.
• [185] Folic acid induces cell type-specific changes in the transcriptome of breast cancer cell lines: a proof-of-concept study. J Nutr Sci. 2016 Apr 26;5:e17. doi: 10.1017/jns.2016.8. eCollection 2016.
• [186] Some HIV antiretrovirals increase oxidative stress and alter chemokine, cytokine or adiponectin production in human adipocytes and macrophages. Antivir Ther. 2007;12(4):489-500.
• [187] Increased sensitivity for troglitazone-induced cytotoxicity using a human in vitro co-culture model. Toxicol In Vitro. 2009 Oct;23(7):1387-95.
• [188] D-Penicillamine targets metastatic melanoma cells with induction of the unfolded protein response (UPR) and Noxa (PMAIP1)-dependent mitochondrial apoptosis. Apoptosis. 2012 Oct;17(10):1079-94.
• [189] Pharmacogenomic analysis of acute promyelocytic leukemia cells highlights CYP26 cytochrome metabolism in differential all-trans retinoic acid sensitivity. Blood. 2007 May 15;109(10):4450-60.
• [190] Global effects of inorganic arsenic on gene expression profile in human macrophages. Mol Immunol. 2009 Feb;46(4):649-56.
• [191] Identification of human cell responses to benzene and benzene metabolites. Genomics. 2007 Sep;90(3):324-33.
• [192] Troglitazone suppresses cell growth of KU812 cells independently of PPARgamma. Eur J Pharmacol. 2002 Feb 1;436(1-2):7-13. doi: 10.1016/s0014-2999(01)01577-1.
• [193] Effects of chlorpromazine with and without UV irradiation on gene expression of HepG2 cells. Mutat Res. 2005 Aug 4;575(1-2):47-60. doi: 10.1016/j.mrfmmm.2005.03.002. Epub 2005 Apr 26.
• [194] Effects of aromatase inhibitors on human osteoblast and osteoblast-like cells: a possible androgenic bone protective effects induced by exemestane. Bone. 2007 Apr;40(4):876-87. doi: 10.1016/j.bone.2006.11.029. Epub 2006 Dec 28.
• [195] Inter-laboratory comparison of human renal proximal tubule (HK-2) transcriptome alterations due to Cyclosporine A exposure and medium exhaustion. Toxicol In Vitro. 2009 Apr;23(3):486-99.
• [196] Arsenite and cadmium promote the development of mammary tumors. Carcinogenesis. 2020 Jul 14;41(7):1005-1014. doi: 10.1093/carcin/bgz176.
• [197] Beta-carotene and apocarotenals promote retinoid signaling in BEAS-2B human bronchioepithelial cells. Arch Biochem Biophys. 2006 Nov 1;455(1):48-60.
• [198] Integrated assessment by multiple gene expression analysis of quercetin bioactivity on anticancer-related mechanisms in colon cancer cells in vitro. Eur J Nutr. 2005 Mar;44(3):143-56. doi: 10.1007/s00394-004-0503-1. Epub 2004 Apr 30.
• [199] Molecular targeting of retinoic acid metabolism in neuroblastoma: the role of the CYP26 inhibitor R116010 in vitro and in vivo. Br J Cancer. 2007 Jun 4;96(11):1675-83.
• [200] Arsenic trioxide-induced apoptosis and differentiation are associated respectively with mitochondrial transmembrane potential collapse and retinoic acid signaling pathways in acute promyelocytic leukemia. Leukemia. 2000 Feb;14(2):262-70. doi: 10.1038/sj.leu.2401650.
• [201] Gene expression signatures after ethanol exposure in differentiating embryoid bodies. Toxicol In Vitro. 2018 Feb;46:66-76.
• [202] Folic acid enforces DNA methylation-mediated transcriptional silencing of PTEN, APC and RARbeta2 tumour suppressor genes in breast cancer. Biochem Biophys Res Commun. 2013 Jan 11;430(2):623-8. doi: 10.1016/j.bbrc.2012.11.103. Epub 2012 Dec 3.
• [203] The PPARgamma ligands PGJ2 and rosiglitazone show a differential ability to inhibit proliferation and to induce apoptosis and differentiation of human glioblastoma cell lines. Int J Oncol. 2004 Aug;25(2):493-502.
• [204] Thalidomide and Its Analogs Differentially Target Fibroblast Growth Factor Receptors: Thalidomide Suppresses FGFR Gene Expression while Pomalidomide Dampens FGFR2 Activity. Chem Res Toxicol. 2019 Apr 15;32(4):589-602. doi: 10.1021/acs.chemrestox.8b00286. Epub 2019 Mar 15.
• [205] Identification of vitamin D3 target genes in human breast cancer tissue. J Steroid Biochem Mol Biol. 2016 Nov;164:90-97.
• [206] Comparative gene expression profiling reveals partially overlapping but distinct genomic actions of different antiestrogens in human breast cancer cells. J Cell Biochem. 2006 Aug 1;98(5):1163-84.
• [207] Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
• [208] The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib. Toxicol Sci. 2023 Dec 21;197(1):69-78. doi: 10.1093/toxsci/kfad099.
• [209] The neuroprotective action of the mood stabilizing drugs lithium chloride and sodium valproate is mediated through the up-regulation of the homeodomain protein Six1. Toxicol Appl Pharmacol. 2009 Feb 15;235(1):124-34.
• [210] Incidence of mutation and deletion in topoisomerase II alpha mRNA of etoposide and mAMSA-resistant cell lines. Jpn J Cancer Res. 2001 Oct;92(10):1133-7. doi: 10.1111/j.1349-7006.2001.tb01069.x.
• [211] HU-331 and Oxidized Cannabidiol Act as Inhibitors of Human Topoisomerase II and . Chem Res Toxicol. 2018 Feb 19;31(2):137-144. doi: 10.1021/acs.chemrestox.7b00302. Epub 2018 Jan 8.
• [212] Interactions between the etoposide derivative F14512 and human type II topoisomerases: implications for the C4 spermine moiety in promoting enzyme-mediated DNA cleavage. Biochemistry. 2011 Apr 19;50(15):3240-9. doi: 10.1021/bi200094z. Epub 2011 Mar 28.
• [213] Methotrexate modulates folate phenotype and inflammatory profile in EA.hy 926 cells. Eur J Pharmacol. 2014 Jun 5;732:60-7.
• [214] Arsenic trioxide exposure to ovarian carcinoma cells leads to decreased level of topoisomerase II and cytotoxicity. Int J Gynecol Cancer. 2006 Jul-Aug;16(4):1552-6. doi: 10.1111/j.1525-1438.2006.00626.x.
• [215] Role of phenytoin in wound healing: microarray analysis of early transcriptional responses in human dermal fibroblasts. Biochem Biophys Res Commun. 2004 Feb 13;314(3):661-6. doi: 10.1016/j.bbrc.2003.12.146.
• [216] Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: application to acetaminophen injury. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):270-80.
• [217] Transcriptome and DNA methylome dynamics during triclosan-induced cardiomyocyte differentiation toxicity. Stem Cells Int. 2018 Oct 29;2018:8608327.
• [218] Expression profiling in squamous carcinoma cells reveals pleiotropic effects of vitamin D3 analog EB1089 signaling on cell proliferation, differentiation, and immune system regulation. Mol Endocrinol. 2002 Jun;16(6):1243-56.
• [219] Identification of a transcriptomic signature of food-relevant genotoxins in human HepaRG hepatocarcinoma cells. Food Chem Toxicol. 2020 Jun;140:111297. doi: 10.1016/j.fct.2020.111297. Epub 2020 Mar 28.
• [220] Quercetin inhibits HGF/c-Met signaling and HGF-stimulated melanoma cell migration and invasion. Mol Cancer. 2015 May 14;14:103. doi: 10.1186/s12943-015-0367-4.
• [221] Rofecoxib modulates multiple gene expression pathways in a clinical model of acute inflammatory pain. Pain. 2007 Mar;128(1-2):136-47.
• [222] Agonists of the retinoic acid- and retinoid X-receptors inhibit hepatocyte growth factor secretion and expression in U87 human astrocytoma cells. Brain Res Mol Brain Res. 2001 Feb 19;87(1):100-8. doi: 10.1016/s0165-3806(00)00154-1.
• [223] Effects of nevirapine and efavirenz on human adipocyte differentiation, gene expression, and release of adipokines and cytokines. Antiviral Res. 2011 Aug;91(2):112-9. doi: 10.1016/j.antiviral.2011.04.018. Epub 2011 May 17.
• [224] The effect of NSAIDs and a COX-2 specific inhibitor on Helicobacter pylori-induced PGE2 and HGF in human gastric fibroblasts. Aliment Pharmacol Ther. 2000 Apr;14 Suppl 1:44-9. doi: 10.1046/j.1365-2036.2000.014s1044.x.
• [225] Combination of thalidomide and cisplatin in an head and neck squamous cell carcinomas model results in an enhanced antiangiogenic activity in vitro and in vivo. Int J Cancer. 2007 Oct 15;121(8):1697-704. doi: 10.1002/ijc.22867.
• [226] Regulation of keratinocyte growth factor and scatter factor in cyclosporin-induced gingival overgrowth. J Oral Pathol Med. 2004 Aug;33(7):391-7. doi: 10.1111/j.1600-0714.2004.00223.x.
• [227] Resveratrol inhibits hydrogen peroxide-induced apoptosis in endothelial cells via the activation of PI3K/Akt by miR-126. J Atheroscler Thromb. 2014;21(2):108-18. doi: 10.5551/jat.19257. Epub 2013 Oct 10.
• [228] Expression profile analysis of colon cancer cells in response to sulindac or aspirin. Biochem Biophys Res Commun. 2002 Mar 29;292(2):498-512.
• [229] Ouabain impairs cell migration, and invasion and alters gene expression of human osteosarcoma U-2 OS cells. Environ Toxicol. 2017 Nov;32(11):2400-2413. doi: 10.1002/tox.22453. Epub 2017 Aug 10.
• [230] Evaluation of a human iPSC-derived BBB model for repeated dose toxicity testing with cyclosporine A as model compound. Toxicol In Vitro. 2021 Jun;73:105112. doi: 10.1016/j.tiv.2021.105112. Epub 2021 Feb 22.
• [231] Lunasin, a novel seed peptide, sensitizes human breast cancer MDA-MB-231 cells to aspirin-arrested cell cycle and induced apoptosis. Chem Biol Interact. 2010 Jul 30;186(2):127-34. doi: 10.1016/j.cbi.2010.04.027. Epub 2010 May 21.
• [232] Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay. Toxicol Sci. 2015 Aug;146(2):311-20. doi: 10.1093/toxsci/kfv094. Epub 2015 May 15.
• [233] Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells. Carcinogenesis. 2006 May;27(5):916-24. doi: 10.1093/carcin/bgi312. Epub 2005 Dec 16.
• [234] PPARgamma controls CD1d expression by turning on retinoic acid synthesis in developing human dendritic cells. J Exp Med. 2006 Oct 2;203(10):2351-62.
• [235] Effect of all-trans retinoic acid on sodium/iodide symporter expression, radioiodine uptake and gene expression profiles in a human anaplastic thyroid carcinoma cell line. Nucl Med Biol. 2006 Oct;33(7):875-82. doi: 10.1016/j.nucmedbio.2006.07.004.
• [236] A comprehensive analysis of Wnt/beta-catenin signaling pathway-related genes and crosstalk pathways in the treatment of As2O3 in renal cancer. Ren Fail. 2018 Nov;40(1):331-339.
• [237] Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma. Nature. 2010 Sep 30;467(7315):596-9. doi: 10.1038/nature09454.
• [238] Rap1/B-Raf signaling is activated in neuroendocrine tumors of the digestive tract and Raf kinase inhibition constitutes a putative therapeutic target. Neuroendocrinology. 2007;85(1):45-53. doi: 10.1159/000100508. Epub 2007 Mar 5.
• [239] Effects of tobacco compounds on gene expression in fetal lung fibroblasts. Environ Toxicol. 2008 Aug;23(4):423-34.
• [240] Inhibition of Super-Enhancer Activity in Autoinflammatory Site-Derived T Cells Reduces Disease-Associated Gene Expression. Cell Rep. 2015 Sep 29;12(12):1986-96. doi: 10.1016/j.celrep.2015.08.046. Epub 2015 Sep 17.
• [241] Chronic occupational exposure to arsenic induces carcinogenic gene signaling networks and neoplastic transformation in human lung epithelial cells. Toxicol Appl Pharmacol. 2012 Jun 1;261(2):204-16.
• [242] DNA array analysis of the effects of aspirin on colon cancer cells: involvement of Rac1. Carcinogenesis. 2004 Jul;25(7):1293-8.
• [243] Apoptosis induced by piroxicam plus cisplatin combined treatment is triggered by p21 in mesothelioma. PLoS One. 2011;6(8):e23569.
• [244] New insights into the mechanisms underlying 5-fluorouracil-induced intestinal toxicity based on transcriptomic and metabolomic responses in human intestinal organoids. Arch Toxicol. 2021 Aug;95(8):2691-2718. doi: 10.1007/s00204-021-03092-2. Epub 2021 Jun 20.
• [245] Association between treatment-emergent suicidal ideation with citalopram and polymorphisms near cyclic adenosine monophosphate response element binding protein in the STAR*D study. Arch Gen Psychiatry. 2007 Jun;64(6):689-97. doi: 10.1001/archpsyc.64.6.689.
• [246] Cannabidiol upregulates melanogenesis through CB1 dependent pathway by activating p38 MAPK and p42/44 MAPK. Chem Biol Interact. 2017 Aug 1;273:107-114. doi: 10.1016/j.cbi.2017.06.005. Epub 2017 Jun 7.
• [247] Distinct genetic profile in peripheral blood mononuclear cells of psoriatic arthritis patients treated with methotrexate and TNF-inhibitors. Clin Rheumatol. 2014 Dec;33(12):1815-21. doi: 10.1007/s10067-014-2807-8. Epub 2014 Oct 24.
• [248] Peroxisome proliferator-activated receptor-gamma ligands suppress fibronectin gene expression in human lung carcinoma cells: involvement of both CRE and Sp1. Am J Physiol Lung Cell Mol Physiol. 2005 Sep;289(3):L419-28. doi: 10.1152/ajplung.00002.2005. Epub 2005 May 20.
• [249] Nonclassical action of retinoic acid on the activation of the cAMP response element-binding protein in normal human bronchial epithelial cells. Mol Biol Cell. 2006 Feb;17(2):566-75. doi: 10.1091/mbc.e05-06-0519. Epub 2005 Nov 9.
• [250] p38 MAPK/PP2Ac/TTP pathway on the connection of TNF- and caspases activation on hydroquinone-induced apoptosis. Carcinogenesis. 2013 Apr;34(4):818-27. doi: 10.1093/carcin/bgs409. Epub 2013 Jan 3.
• [251] Glycyrrhizin attenuates histamine-mediated MUC5AC upregulation, inflammatory cytokine production, and aquaporin 5 downregulation through suppressing the NF-B pathway in human nasal epithelial cells. Chem Biol Interact. 2018 Apr 1;285:21-26. doi: 10.1016/j.cbi.2018.02.010. Epub 2018 Feb 13.
• [252] In vitro and in vivo irinotecan-induced changes in expression profiles of cell cycle and apoptosis-associated genes in acute myeloid leukemia cells. Mol Cancer Ther. 2005 Jun;4(6):885-900.
• [253] Epigenetic influences of low-dose bisphenol A in primary human breast epithelial cells. Toxicol Appl Pharmacol. 2010 Oct 15;248(2):111-21.
• [254] Regulation of regional expression in rat brain PC2 by thyroid hormone/characterization of novel negative thyroid hormone response elements in the PC2 promoter. Am J Physiol Endocrinol Metab. 2005 Jan;288(1):E236-45. doi: 10.1152/ajpendo.00144.2004.
• [255] Transcriptional profiling in the human prefrontal cortex: evidence for two activational states associated with cocaine abuse. Pharmacogenomics J. 2003;3(1):27-40.
• [256] Clinical determinants of response to irinotecan-based therapy derived from cell line models. Clin Cancer Res. 2008 Oct 15;14(20):6647-55.
• [257] Cyclosporine A--induced oxidative stress in human renal mesangial cells: a role for ERK 1/2 MAPK signaling. Toxicol Sci. 2012 Mar;126(1):101-13.
• [258] Prediction of the contact sensitizing potential of chemicals using analysis of gene expression changes in human THP-1 monocytes. Toxicol Lett. 2010 Nov 10;199(1):51-9.
• [259] Gene expression profile of human lymphoid CEM cells sensitive and resistant to glucocorticoid-evoked apoptosis. Genomics. 2003 Jun;81(6):543-55.
• [260] Classification of heavy-metal toxicity by human DNA microarray analysis. Environ Sci Technol. 2007 May 15;41(10):3769-74.
• [261] NFATc4 mediates ethanol-triggered hepatocyte senescence. Toxicol Lett. 2021 Oct 10;350:10-21. doi: 10.1016/j.toxlet.2021.06.018. Epub 2021 Jun 27.
• [262] Methamphetamine alters the normal progression by inducing cell cycle arrest in astrocytes. PLoS One. 2014 Oct 7;9(10):e109603.
• [263] Robustness testing and optimization of an adverse outcome pathway on cholestatic liver injury. Arch Toxicol. 2020 Apr;94(4):1151-1172. doi: 10.1007/s00204-020-02691-9. Epub 2020 Mar 10.
• [264] Cannabidiol Modulates the Expression of Alzheimer's Disease-Related Genes in Mesenchymal Stem Cells. Int J Mol Sci. 2016 Dec 23;18(1):26. doi: 10.3390/ijms18010026.
• [265] A potential role of calpains in sulfonylureas (SUs) -mediated death of human pancreatic cancer cells (1.2B4). Toxicol In Vitro. 2021 Jun;73:105128. doi: 10.1016/j.tiv.2021.105128. Epub 2021 Feb 27.
• [266] Arsenic induces cell apoptosis in cultured osteoblasts through endoplasmic reticulum stress. Toxicol Appl Pharmacol. 2009 Dec 1;241(2):173-81. doi: 10.1016/j.taap.2009.08.011. Epub 2009 Aug 18.
• [267] Synthesis, biological activity and structure-activity relationships of new benzoic acid-based protein tyrosine phosphatase inhibitors endowed with insulinomimetic effects in mouse C2C12 skeletal muscle cells. Eur J Med Chem. 2014 Jan;71:112-27. doi: 10.1016/j.ejmech.2013.11.001. Epub 2013 Nov 11.
• [268] Identification of novel low-dose bisphenol a targets in human foreskin fibroblast cells derived from hypospadias patients. PLoS One. 2012;7(5):e36711. doi: 10.1371/journal.pone.0036711. Epub 2012 May 4.
• [269] Grouping of histone deacetylase inhibitors and other toxicants disturbing neural crest migration by transcriptional profiling. Neurotoxicology. 2015 Sep;50:56-70.
• [270] Coumarins from Angelica decursiva inhibit -glucosidase activity and protein tyrosine phosphatase 1B. Chem Biol Interact. 2016 May 25;252:93-101. doi: 10.1016/j.cbi.2016.04.020. Epub 2016 Apr 13.
• [271] Proteomic analysis of the cellular response to a potent sensitiser unveils the dynamics of haptenation in living cells. Toxicology. 2020 Dec 1;445:152603. doi: 10.1016/j.tox.2020.152603. Epub 2020 Sep 28.
• [272] Polymorphism in the ERCC2 codon 751 is associated with arsenic-induced premalignant hyperkeratosis and significant chromosome aberrations. Carcinogenesis. 2007 Mar;28(3):672-6. doi: 10.1093/carcin/bgl181. Epub 2006 Oct 17.
• [273] Cannabidiol induces antioxidant pathways in keratinocytes by targeting BACH1. Redox Biol. 2020 Jan;28:101321. doi: 10.1016/j.redox.2019.101321. Epub 2019 Sep 5.
• [274] Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells. Cancer Res. 2002 Nov 1;62(21):6246-54.
• [275] Molecular mechanisms of hepatotoxic cholestasis by clavulanic acid: Role of NRF2 and FXR pathways. Food Chem Toxicol. 2021 Dec;158:112664. doi: 10.1016/j.fct.2021.112664. Epub 2021 Nov 9.
• [276] Retinoic acid induces Gpx2 gene expression in MCF-7 human breast cancer cells. J Nutr. 1999 Oct;129(10):1846-54. doi: 10.1093/jn/129.10.1846.
• [277] Expression of gastrointestinal glutathione peroxidase is inversely correlated to the presence of hepatitis C virus subgenomic RNA in human liver cells. J Biol Chem. 2005 Mar 11;280(10):8831-41. doi: 10.1074/jbc.M413730200. Epub 2004 Dec 28.
• [278] Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell. 2009 Aug 21;138(4):645-659. doi: 10.1016/j.cell.2009.06.034. Epub 2009 Aug 13.
• [279] Identification of biomarkers modulated by the rexinoid LGD1069 (bexarotene) in human breast cells using oligonucleotide arrays. Cancer Res. 2006 Dec 15;66(24):12009-18.
• [280] Dose- and time-dependent transcriptional response of Ishikawa cells exposed to genistein. Toxicol Sci. 2016 May;151(1):71-87.
• [281] Arsenic trioxide inhibits EMT in hepatocellular carcinoma by promoting lncRNA MEG3 via PKM2. Biochem Biophys Res Commun. 2019 Jun 11;513(4):834-840. doi: 10.1016/j.bbrc.2019.04.081. Epub 2019 Apr 16.
• [282] Thalidomide suppresses angiogenesis and immune evasion via lncRNA FGD5-AS1/miR-454-3p/ZEB1 axis-mediated VEGFA expression and PD-1/PD-L1 checkpoint in NSCLC. Chem Biol Interact. 2021 Nov 1;349:109652. doi: 10.1016/j.cbi.2021.109652. Epub 2021 Sep 11.
• [283] ?9-tetrahydrocannabinol inhibits epithelial-mesenchymal transition and metastasis by targeting matrix metalloproteinase-9 in endometrial cancer. Oncol Lett. 2018 Jun;15(6):8527-8535. doi: 10.3892/ol.2018.8407. Epub 2018 Apr 2.
• [284] Anti-androgen 2-hydroxyflutamide modulates cadherin, catenin and androgen receptor phosphorylation in androgen-sensitive LNCaP and androgen-independent PC3 prostate cancer cell lines acting via PI3K/Akt and MAPK/ERK1/2 pathways. Toxicol In Vitro. 2017 Apr;40:324-335. doi: 10.1016/j.tiv.2017.01.019. Epub 2017 Feb 2.
• [285] Quercetin and Cisplatin combined treatment altered cell cycle and mitogen activated protein kinase expressions in malignant mesotelioma cells. BMC Complement Altern Med. 2016 Aug 11;16(1):281. doi: 10.1186/s12906-016-1267-x.
• [286] Troglitazone activates p21Cip/WAF1 through the ERK pathway in HCT15 human colorectal cancer cells. Cancer Lett. 2002 May 28;179(2):185-95. doi: 10.1016/s0304-3835(01)00869-2.
• [287] Integrated analysis of rifampicin-induced microRNA and gene expression changes in human hepatocytes. Drug Metab Pharmacokinet. 2014;29(4):333-40.
• [288] Arsenite-induced downregulation of occludin in mouse lungs and BEAS-2B cells via the ROS/ERK/ELK1/MLCK and ROS/p38 MAPK signaling pathways. Toxicol Lett. 2020 Oct 10;332:146-154. doi: 10.1016/j.toxlet.2020.07.010. Epub 2020 Jul 16.
• [289] Transcriptomic Analysis of Stem Cells Treated with Moringin or Cannabidiol: Analogies and Differences in Inflammation Pathways. Int J Mol Sci. 2019 Nov 30;20(23):6039. doi: 10.3390/ijms20236039.
• [290] Iron-mediated H2O2 production as a mechanism for cell type-specific inhibition of tumor necrosis factor alpha-induced but not interleukin-1beta-induced IkappaB kinase complex/nuclear factor-kappaB activation. J Biol Chem. 2005 Jan 28;280(4):2912-23. doi: 10.1074/jbc.M409524200. Epub 2004 Nov 17.
• [291] Quercetin potentiates apoptosis by inhibiting nuclear factor-kappaB signaling in H460 lung cancer cells. Biol Pharm Bull. 2013;36(6):944-51. doi: 10.1248/bpb.b12-01004.
• [292] Suppression of mammary carcinoma growth by retinoic acid: proapoptotic genes are targets for retinoic acid receptor and cellular retinoic acid-binding protein II signaling. Cancer Res. 2005 Sep 15;65(18):8193-9. doi: 10.1158/0008-5472.CAN-05-1177.
• [293] Hydroquinone Exposure Worsens Rheumatoid Arthritis through the Activation of the Aryl Hydrocarbon Receptor and Interleukin-17 Pathways. Antioxidants (Basel). 2021 Jun 7;10(6):929. doi: 10.3390/antiox10060929.
• [294] Dexamethasone and the inflammatory response in explants of human omental adipose tissue. Mol Cell Endocrinol. 2010 Feb 5;315(1-2):292-8.
• [295] Identification of genes linked to gefitinib treatment in prostate cancer cell lines with or without resistance to androgen: a clue to application of gefitinib to hormone-resistant prostate cancer. Oncol Rep. 2006 Jun;15(6):1453-60.
• [296] The thioredoxin system mediates redox-induced cell death in human colon cancer cells: implications for the mechanism of action of anticancer agents. Cancer Res. 2008 Oct 15;68(20):8269-77. doi: 10.1158/0008-5472.CAN-08-2010.
• [297] Development of an alternative zebrafish model for drug-induced intestinal toxicity. J Appl Toxicol. 2018 Feb;38(2):259-273. doi: 10.1002/jat.3520. Epub 2017 Oct 13.
• [298] Response rate of fibrosarcoma cells to cytotoxic drugs on the expression level correlates to the therapeutic response rate of fibrosarcomas and is mediated by regulation of apoptotic pathways. BMC Cancer. 2005 Jul 7;5:74. doi: 10.1186/1471-2407-5-74.
• [299] Suppression of RAGE as a basis of simvastatin-dependent plaque stabilization in type 2 diabetes. Arterioscler Thromb Vasc Biol. 2006 Dec;26(12):2716-23.
• [300] G2 delay induced by nitrogen mustard in human cells affects cyclin A/cdk2 and cyclin B1/cdc2-kinase complexes differently. J Biol Chem. 1993 Apr 15;268(11):8298-308.
• [301] Ribavirin inhibits colorectal cancer growth by downregulating PRMT5 expression and H3R8me2s and H4R3me2s accumulation. Toxicol Appl Pharmacol. 2021 Mar 15;415:115450. doi: 10.1016/j.taap.2021.115450. Epub 2021 Feb 9.
• [302] Sulindac induces specific degradation of the HPV oncoprotein E7 and causes growth arrest and apoptosis in cervical carcinoma cells. Cancer Lett. 2007 Jan 8;245(1-2):103-11. doi: 10.1016/j.canlet.2005.12.034. Epub 2006 Feb 20.
• [303] Simvastatin inactivates beta1-integrin and extracellular signal-related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells. Cancer Sci. 2007 Jun;98(6):890-9.
• [304] CDK4/6 inhibition provides a potent adjunct to Her2-targeted therapies in preclinical breast cancer models. Genes Cancer. 2014 Jul;5(7-8):261-72. doi: 10.18632/genesandcancer.24.
• [305] Molecular mechanisms controlling the rate and specificity of catechol O-methylation by human soluble catechol O-methyltransferase. Mol Pharmacol. 2001 Feb;59(2):393-402. doi: 10.1124/mol.59.2.393.
• [306] Effects of modafinil on the sleep EEG depend on Val158Met genotype of COMT. Sleep. 2010 Aug;33(8):1027-35. doi: 10.1093/sleep/33.8.1027.
• [307] Tolcapone increases plasma catecholamine levels in patients with Parkinson's disease. Parkinsonism Relat Disord. 2001 Apr;7(2):93-96. doi: 10.1016/s1353-8020(00)00027-4.
• [308] High folic acid increases cell turnover and lowers differentiation and iron content in human HT29 colon cancer cells. Br J Nutr. 2008 Apr;99(4):703-8.
• [309] Consequences of the natural retinoid/retinoid X receptor ligands action in human breast cancer MDA-MB-231 cell line: Focus on functional proteomics. Toxicol Lett. 2017 Nov 5;281:26-34. doi: 10.1016/j.toxlet.2017.09.001. Epub 2017 Sep 5.
• [310] 1,25-Dihydroxyvitamin D3 suppresses gene expression of eukaryotic translation initiation factor 2 in human promyelocytic leukemia HL-60 cells. Cell Struct Funct. 2005;30(1):1-6. doi: 10.1247/csf.30.1.
• [311] Capsaicin promotes a more aggressive gene expression phenotype and invasiveness in null-TRPV1 urothelial cancer cells. Carcinogenesis. 2011 May;32(5):686-94. doi: 10.1093/carcin/bgr025. Epub 2011 Feb 10.
• [312] Identification of potential biomarkers for predicting acute dermal irritation by proteomic analysis. J Appl Toxicol. 2011 Nov;31(8):762-72.
• [313] Ornithine decarboxylase antizyme upregulates DNA-dependent protein kinase and enhances the nonhomologous end-joining repair of DNA double-strand breaks in human oral cancer cells. Biochemistry. 2007 Aug 7;46(31):8920-32. doi: 10.1021/bi7000328. Epub 2007 Jul 14.
• [314] Proteomic analysis of the nucleus accumbens of rats with different vulnerability to cocaine addiction. Neuropharmacology. 2009 Jul;57(1):41-8. doi: 10.1016/j.neuropharm.2009.04.005. Epub 2009 Apr 22.
• [315] The Isoniazid Metabolites Hydrazine and Pyridoxal Isonicotinoyl Hydrazone Modulate Heme Biosynthesis. Toxicol Sci. 2019 Mar 1;168(1):209-224. doi: 10.1093/toxsci/kfy294.
• [316] Keratinocyte gene expression profiles discriminate sensitizing and irritating compounds. Toxicol Sci. 2010 Sep;117(1):81-9.
• [317] Gene expression profiling of rheumatoid arthritis synovial cells treated with antirheumatic drugs. J Biomol Screen. 2007 Apr;12(3):328-40. doi: 10.1177/1087057107299261. Epub 2007 Mar 22.
• [318] Retinoic acid-induced downmodulation of telomerase activity in human cancer cells. Exp Mol Pathol. 2005 Oct;79(2):108-17.
• [319] Activation of PPAR and inhibition of cell proliferation reduces key proteins associated with the basal subtype of bladder cancer in As3+-transformed UROtsa cells. PLoS One. 2020 Aug 21;15(8):e0237976. doi: 10.1371/journal.pone.0237976. eCollection 2020.
• [320] Direct and indirect effects of retinoic acid on human Th2 cytokine and chemokine expression by human T lymphocytes. BMC Immunol. 2006 Nov 21;7:27. doi: 10.1186/1471-2172-7-27.
• [321] Cannabinoid receptor type 2 agonists induce transcription of the mu-opioid receptor gene in Jurkat T cells. Mol Pharmacol. 2006 Apr;69(4):1486-91. doi: 10.1124/mol.105.018325. Epub 2006 Jan 24.
• [322] Transcriptome-based functional classifiers for direct immunotoxicity. Arch Toxicol. 2014 Mar;88(3):673-89.
• [323] Anti-oncogenic and pro-differentiation effects of clorgyline, a monoamine oxidase A inhibitor, on high grade prostate cancer cells. BMC Med Genomics. 2009 Aug 20;2:55. doi: 10.1186/1755-8794-2-55.
• [324] Darinaparsin: solid tumor hypoxic cytotoxin and radiosensitizer. Clin Cancer Res. 2012 Jun 15;18(12):3366-76.
• [325] Lack of uniform platelet activation in patients after ischemic stroke and choice of antiplatelet therapy. Thromb Res. 2004;113(3-4):197-204. doi: 10.1016/j.thromres.2004.03.002.
• [326] Circulating endothelial progenitor cells in multiple myeloma: implications and significance. Blood. 2005 Apr 15;105(8):3286-94. doi: 10.1182/blood-2004-06-2101. Epub 2004 Dec 23.
• [327] Bisphenol A Exposure Changes the Transcriptomic and Proteomic Dynamics of Human Retinoblastoma Y79 Cells. Genes (Basel). 2021 Feb 11;12(2):264. doi: 10.3390/genes12020264.
• [328] Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells. Toxicol Sci. 2023 Feb 17;191(2):227-238. doi: 10.1093/toxsci/kfac131.
• [329] All trans retinoic acid nanodisks enhance retinoic acid receptor mediated apoptosis and cell cycle arrest in mantle cell lymphoma. Br J Haematol. 2010 Jul;150(2):158-69. doi: 10.1111/j.1365-2141.2010.08209.x. Epub 2010 May 9.
• [330] A two-hybrid yeast assay to quantify the effects of xenobiotics on retinoid X receptor-mediated gene expression. Toxicol Lett. 2008 Feb 15;176(3):198-206. doi: 10.1016/j.toxlet.2007.11.006. Epub 2007 Dec 3.
• [331] Transient receptor potential vanilloid-1 signaling as a regulator of human sebocyte biology. J Invest Dermatol. 2009 Feb;129(2):329-39. doi: 10.1038/jid.2008.258. Epub 2008 Sep 4.
• [332] Phthalates efficiently bind to human peroxisome proliferator activated receptor and retinoid X receptor , , subtypes: an in silico approach. J Appl Toxicol. 2014 Jul;34(7):754-65. doi: 10.1002/jat.2902. Epub 2013 Jul 11.
• [333] Photoaffinity labeling of human retinoid X receptor beta (RXRbeta) with 9-cis-retinoic acid: identification of phytanic acid, docosahexaenoic acid, and lithocholic acid as ligands for RXRbeta. Biochemistry. 2002 Apr 16;41(15):4883-90. doi: 10.1021/bi0121151.
• [334] Gene induction and apoptosis in human hepatocellular carci-noma cells SMMC-7721 exposed to 5-aza-2'-deoxycytidine. Chin Med J (Engl). 2007 Sep 20;120(18):1626-31.
• [335] Application of cDNA microarray to the study of arsenic-induced liver diseases in the population of Guizhou, China. Toxicol Sci. 2001 Jan;59(1):185-92.
• [336] Pharmacological inhibition of Rho-kinase (ROCK) signaling enhances cisplatin resistance in neuroblastoma cells. Int J Oncol. 2010 Nov;37(5):1297-305. doi: 10.3892/ijo_00000781.
• [337] A common polymorphism in the 5' UTR of ERCC5 creates an upstream ORF that confers resistance to platinum-based chemotherapy. Genes Dev. 2015 Sep 15;29(18):1891-6. doi: 10.1101/gad.261867.115. Epub 2015 Sep 3.
• [338] Utilization of CDKN1A/p21 gene for class discrimination of DNA damage-induced clastogenicity. Toxicology. 2014 Jan 6;315:8-16. doi: 10.1016/j.tox.2013.10.009. Epub 2013 Nov 6.
• [339] Melanoma coordinates general and cell-specific mechanisms to promote methotrexate resistance. Exp Cell Res. 2012 Jun 10;318(10):1146-59.
• [340] A gene signature-based approach identifies thioridazine as an inhibitor of phosphatidylinositol-3'-kinase (PI3K)/AKT pathway in ovarian cancer cells. Gynecol Oncol. 2011 Jan;120(1):121-7. doi: 10.1016/j.ygyno.2010.10.003. Epub 2010 Oct 29.
• [341] Activation of the p38 MAPK/Akt/ERK1/2 signal pathways is required for the protein stabilization of CDC6 and cyclin D1 in low-dose arsenite-induced cell proliferation. J Cell Biochem. 2010 Dec 15;111(6):1546-55. doi: 10.1002/jcb.22886.
• [342] Vitamin D receptor as a master regulator of the c-MYC/MXD1 network. Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):18827-32. doi: 10.1073/pnas.1210037109. Epub 2012 Oct 29.
• [343] New 2,6,9-trisubstituted adenines as adenosine receptor antagonists: a preliminary SAR profile. Purinergic Signal. 2007 Sep;3(4):339-46. doi: 10.1007/s11302-007-9068-9. Epub 2007 Sep 19.
• [344] Mitochondrial Uncoupling Induces Epigenome Remodeling and Promotes Differentiation in Neuroblastoma. Cancer Res. 2023 Jan 18;83(2):181-194. doi: 10.1158/0008-5472.CAN-22-1029.
• [345] Identification of mechanisms of action of bisphenol a-induced human preadipocyte differentiation by transcriptional profiling. Obesity (Silver Spring). 2014 Nov;22(11):2333-43.
• [346] The genomic response of a human uterine endometrial adenocarcinoma cell line to 17alpha-ethynyl estradiol. Toxicol Sci. 2009 Jan;107(1):40-55.
• [347] Pattern of expression of apoptosis and inflammatory genes in humans exposed to arsenic and/or fluoride. Sci Total Environ. 2010 Jan 15;408(4):760-7. doi: 10.1016/j.scitotenv.2009.11.016. Epub 2009 Dec 4.
• [348] Sulindac suppresses beta-catenin expression in human cancer cells. Eur J Pharmacol. 2008 Mar 31;583(1):26-31. doi: 10.1016/j.ejphar.2007.12.034. Epub 2008 Feb 5.
• [349] Multifaceted suppression of aggressive behavior of thyroid carcinoma by all-trans retinoic acid induced re-differentiation. Mol Cell Endocrinol. 2012 Jan 2;348(1):260-9. doi: 10.1016/j.mce.2011.09.002. Epub 2011 Sep 6.
• [350] Arsenic trioxide and 2-methoxyestradiol reduce beta-catenin accumulation after proteasome inhibition and enhance the sensitivity of myeloma cells to Bortezomib. Leuk Res. 2008 Nov;32(11):1674-83. doi: 10.1016/j.leukres.2008.03.039. Epub 2008 May 15.
• [351] Effect of aspirin on the Wnt/beta-catenin pathway is mediated via protein phosphatase 2A. Oncogene. 2006 Oct 19;25(49):6447-56. doi: 10.1038/sj.onc.1209658. Epub 2006 Jul 31.
• [352] Benzene metabolite hydroquinone induces apoptosis of bone marrow mononuclear cells through inhibition of -catenin signaling. Toxicol In Vitro. 2018 Feb;46:361-369. doi: 10.1016/j.tiv.2017.08.018. Epub 2017 Sep 5.
• [353] Anthelmintic Niclosamide Disrupts the Interplay of p65 and FOXM1/-catenin and Eradicates Leukemia Stem Cells in Chronic Myelogenous Leukemia. Clin Cancer Res. 2017 Feb 1;23(3):789-803. doi: 10.1158/1078-0432.CCR-16-0226. Epub 2016 Aug 4.
• [354] Integrated 'omics analysis reveals new drug-induced mitochondrial perturbations in human hepatocytes. Toxicol Lett. 2018 Jun 1;289:1-13.
• [355] Effects of acute ethanol treatment on NCCIT cells and NCCIT cell-derived embryoid bodies (EBs). Toxicol In Vitro. 2010 Sep;24(6):1696-704. doi: 10.1016/j.tiv.2010.05.017. Epub 2010 May 26.
• [356] Arsenic trioxide (As(2)O(3)) induced apoptosis and its mechanisms in a human esophageal squamous carcinoma cell line. Chin Med J (Engl). 2002 Feb;115(2):280-5.
• [357] The differential cancer growth associated with anaesthetics in a cancer xenograft model of mice: mechanisms and implications of postoperative cancer recurrence. Cell Biol Toxicol. 2023 Aug;39(4):1561-1575. doi: 10.1007/s10565-022-09747-9. Epub 2022 Aug 12.
• [358] Restoration by aspirin of impaired plasma maspin level in human breast cancer. Acta Oncol. 2006;45(2):184-7. doi: 10.1080/02841860500516584.
• [359] IKK inibition by a glucosamine derivative enhances Maspin expression in osteosarcoma cell line. Chem Biol Interact. 2017 Jan 25;262:19-28. doi: 10.1016/j.cbi.2016.12.005. Epub 2016 Dec 6.
• [360] Effects of 5-Aza-CdR on cell proliferation of breast cancer cell line MDA-MB-435S and expression of maspin gene. J Huazhong Univ Sci Technolog Med Sci. 2007 Oct;27(5):543-6. doi: 10.1007/s11596-007-0517-z.
• [361] The thioxotriazole copper(II) complex A0 induces endoplasmic reticulum stress and paraptotic death in human cancer cells. J Biol Chem. 2009 Sep 4;284(36):24306-19.
• [362] Gene expression profiling in Ishikawa cells: a fingerprint for estrogen active compounds. Toxicol Appl Pharmacol. 2009 Apr 1;236(1):85-96.
• [363] Regulation of gene expression and inhibition of experimental prostate cancer bone metastasis by dietary genistein. Neoplasia. 2004 Jul-Aug;6(4):354-63. doi: 10.1593/neo.03478.
• [364] Cannabidiol Modulates the Immunophenotype and Inhibits the Activation of the Inflammasome in Human Gingival Mesenchymal Stem Cells. Front Physiol. 2016 Nov 24;7:559. doi: 10.3389/fphys.2016.00559. eCollection 2016.
• [365] Chronic senescent human mesenchymal stem cells as possible contributor to the wound healing disorder after exposure to the alkylating agent sulfur mustard. Arch Toxicol. 2021 Feb;95(2):727-747. doi: 10.1007/s00204-020-02946-5. Epub 2021 Jan 25.
• [366] Aspirin induces apoptosis through the blockade of IL-6-STAT3 signaling pathway in human glioblastoma A172 cells. Biochem Biophys Res Commun. 2009 Sep 18;387(2):342-7. doi: 10.1016/j.bbrc.2009.07.022. Epub 2009 Jul 10.
• [367] Expression and promoter methylation status of mismatch repair gene hMLH1 and hMSH2 in epithelial ovarian cancer. Aust N Z J Obstet Gynaecol. 2008 Oct;48(5):505-9. doi: 10.1111/j.1479-828X.2008.00892.x.
• [368] Epigenetic alteration of mismatch repair genes in the population chronically exposed to arsenic in West Bengal, India. Environ Res. 2018 May;163:289-296. doi: 10.1016/j.envres.2018.01.002. Epub 2018 Feb 27.
• [369] DNA demethylation by 5-aza-2-deoxycytidine treatment abrogates 17 beta-estradiol-induced cell growth and restores expression of DNA repair genes in human breast cancer cells. Cancer Lett. 2012 Mar;316(1):62-9. doi: 10.1016/j.canlet.2011.10.022. Epub 2011 Oct 23.
• [370] Targeting multiple cannabinoid anti-tumour pathways with a resorcinol derivative leads to inhibition of advanced stages of breast cancer. Br J Pharmacol. 2014 Oct;171(19):4464-77. doi: 10.1111/bph.12803. Epub 2014 Sep 5.
• [371] Calcium pantothenate modulates gene expression in proliferating human dermal fibroblasts. Exp Dermatol. 2009 Nov;18(11):969-78. doi: 10.1111/j.1600-0625.2009.00884.x. Epub 2009 Apr 8.
• [372] Study of As(2)O(3) regulating proliferation and apoptosis of Tca8113 cells by inhibiting the expression of Id-1. Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):1932-1937. doi: 10.1080/21691401.2019.1613419.
• [373] Endoplasmic reticulum stress contributes to arsenic trioxide-induced intrinsic apoptosis in human umbilical and bone marrow mesenchymal stem cells. Environ Toxicol. 2016 Mar;31(3):314-28.
• [374] Inhibiting ubiquitination causes an accumulation of SUMOylated newly synthesized nuclear proteins at PML bodies. J Biol Chem. 2019 Oct 18;294(42):15218-15234. doi: 10.1074/jbc.RA119.009147. Epub 2019 Jul 8.
• [375] Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761. doi: 10.1016/j.taap.2019.114761. Epub 2019 Sep 15.
• [376] Comparative proteomics reveals concordant and discordant biochemical effects of caffeine versus epigallocatechin-3-gallate in human endothelial cells. Toxicol Appl Pharmacol. 2019 Sep 1;378:114621. doi: 10.1016/j.taap.2019.114621. Epub 2019 Jun 10.
• [377] "Exposure to the insecticides permethrin and malathion induces leukemia and lymphoma-associated gene aberrations in vitro". Toxicol In Vitro. 2017 Oct;44:17-26. doi: 10.1016/j.tiv.2017.06.013. Epub 2017 Jun 15.
• [378] Translocation t(12;21) is related to in vitro cellular drug sensitivity to doxorubicin and etoposide in childhood acute lymphoblastic leukemia. Blood. 2004 Oct 15;104(8):2452-7. doi: 10.1182/blood-2003-12-4426. Epub 2004 Jun 24.
• [379] Copper deprivation enhances the chemosensitivity of pancreatic cancer to rapamycin by mTORC1/2 inhibition. Chem Biol Interact. 2023 Sep 1;382:110546. doi: 10.1016/j.cbi.2023.110546. Epub 2023 Jun 7.
• [380] Transcriptional signature of human macrophages exposed to the environmental contaminant benzo(a)pyrene. Toxicol Sci. 2010 Apr;114(2):247-59.
• [381] Sulforaphane-induced apoptosis in human leukemia HL-60 cells through extrinsic and intrinsic signal pathways and altering associated genes expression assayed by cDNA microarray. Environ Toxicol. 2017 Jan;32(1):311-328.
• [382] Chrysin ameliorates hepatic steatosis induced by a diet deficient in methionine and choline by inducing the secretion of hepatocyte nuclear factor 4-dependent very low-density lipoprotein. J Biochem Mol Toxicol. 2020 Jul;34(7):e22497. doi: 10.1002/jbt.22497. Epub 2020 Mar 27.
• [383] Monosaccharide-induced lipogenesis regulates the human hepatic sex hormone-binding globulin gene. J Clin Invest. 2007 Dec;117(12):3979-87. doi: 10.1172/JCI32249.
• [384] Repression of hepatocyte nuclear factor 4 alpha by AP-1 underlies dyslipidemia associated with retinoic acid. J Lipid Res. 2019 Apr;60(4):794-804. doi: 10.1194/jlr.M088880. Epub 2019 Feb 1.
• [385] Rimonabant suppresses RNA transcription of hepatitis B virus by inhibiting hepatocyte nuclear factor 4. Microbiol Immunol. 2020 May;64(5):345-355. doi: 10.1111/1348-0421.12777. Epub 2020 Feb 25.
• [386] Omics-based responses induced by bosentan in human hepatoma HepaRG cell cultures. Arch Toxicol. 2018 Jun;92(6):1939-1952.
• [387] Dexamethasone-mediated up-regulation of human CYP2A6 involves the glucocorticoid receptor and increased binding of hepatic nuclear factor 4 alpha to the proximal promoter. Mol Pharmacol. 2008 Feb;73(2):451-60.
• [388] The effect of estrogen compounds on human embryoid bodies. Reprod Sci. 2013 Jun;20(6):661-9. doi: 10.1177/1933719112462630. Epub 2012 Nov 26.
• [389] Pyrethroid insecticides influence the signal transduction in T helper lymphocytes from atopic and nonatopic subjects. Inflamm Res. 2003 Apr;52(4):154-63. doi: 10.1007/s000110300066.
• [390] eIF4E is a critical regulator of human papillomavirus (HPV)-immortalized cervical epithelial (H8) cell growth induced by nicotine. Toxicology. 2019 May 1;419:1-10. doi: 10.1016/j.tox.2019.02.017. Epub 2019 Mar 2.
• [391] Antidepressant drug sertraline modulates AMPK-MTOR signaling-mediated autophagy via targeting mitochondrial VDAC1 protein. Autophagy. 2021 Oct;17(10):2783-2799. doi: 10.1080/15548627.2020.1841953. Epub 2020 Nov 9.
• [392] EGFR tyrosine kinase inhibitors activate autophagy as a cytoprotective response in human lung cancer cells. PLoS One. 2011;6(6):e18691. doi: 10.1371/journal.pone.0018691. Epub 2011 Jun 2.
• [393] Repression of Kisspeptin1 weakens hydrogen peroxide-caused injury in HTR8 cells via adjusting PI3K/AKT/mTOR pathway. J Biochem Mol Toxicol. 2020 May;34(5):e22461. doi: 10.1002/jbt.22461. Epub 2020 Feb 11.
• [394] Establishment of a 13 genes-based molecular prediction score model to discriminate the neurotoxic potential of food relevant-chemicals. Toxicol Lett. 2022 Feb 1;355:1-18. doi: 10.1016/j.toxlet.2021.10.013. Epub 2021 Nov 5.
• [395] Quercetin inhibits angiogenesis mediated human prostate tumor growth by targeting VEGFR- 2 regulated AKT/mTOR/P70S6K signaling pathways. PLoS One. 2012;7(10):e47516. doi: 10.1371/journal.pone.0047516. Epub 2012 Oct 18.
• [396] Hydroquinone-induced endoplasmic reticulum stress affects TK6 cell autophagy and apoptosis via ATF6-mTOR. Environ Toxicol. 2023 Aug;38(8):1874-1890. doi: 10.1002/tox.23814. Epub 2023 May 6.
• [397] Interactive gene expression pattern in prostate cancer cells exposed to phenolic antioxidants. Life Sci. 2002 Mar 1;70(15):1821-39.
• [398] Prostaglandin E2 and dexamethasone inhibit IL-12 receptor expression and IL-12 responsiveness. J Immunol. 1998 Sep 15;161(6):2723-30.
• [399] Functional expression of IL-12 receptor by human eosinophils: IL-12 promotes eosinophil apoptosis. J Immunol. 2001 Jul 15;167(2):1039-46. doi: 10.4049/jimmunol.167.2.1039.
• [400] Effect of aflatoxin B(1), benzo[a]pyrene, and methapyrilene on transcriptomic and epigenetic alterations in human liver HepaRG cells. Food Chem Toxicol. 2018 Nov;121:214-223. doi: 10.1016/j.fct.2018.08.034. Epub 2018 Aug 26.
• [401] Vgamma9/Vdelta2 T lymphocytes in Italian patients with Beh?et's disease: evidence for expansion, and tumour necrosis factor receptor II and interleukin-12 receptor beta1 expression in active disease. Arthritis Res Ther. 2003;5(5):R262-8. doi: 10.1186/ar785. Epub 2003 Jun 30.
• [402] Unique signatures of stress-induced senescent human astrocytes. Exp Neurol. 2020 Dec;334:113466. doi: 10.1016/j.expneurol.2020.113466. Epub 2020 Sep 17.
• [403] Histamine H4 receptor agonists have more activities than H4 agonism in antigen-specific human T-cell responses. Immunology. 2007 Jun;121(2):266-75. doi: 10.1111/j.1365-2567.2007.02574.x. Epub 2007 Mar 7.
• [404] Mifepristone induced progesterone withdrawal reveals novel regulatory pathways in human endometrium. Mol Hum Reprod. 2007 Sep;13(9):641-54.
• [405] Re-expression of CXCL14, a common target for epigenetic silencing in lung cancer, induces tumor necrosis. Oncogene. 2010 Sep 16;29(37):5159-70. doi: 10.1038/onc.2010.255. Epub 2010 Jun 21.
• [406] Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
• [407] Changes in gene expression profiles in response to selenium supplementation among individuals with arsenic-induced pre-malignant skin lesions. Toxicol Lett. 2007 Mar 8;169(2):162-76. doi: 10.1016/j.toxlet.2007.01.006. Epub 2007 Jan 19.
• [408] CXCL14 downregulation in human keratinocytes is a potential biomarker for a novel in vitro skin sensitization test. Toxicol Appl Pharmacol. 2020 Jan 1;386:114828. doi: 10.1016/j.taap.2019.114828. Epub 2019 Nov 14.
• [409] Effects of progesterone treatment on expression of genes involved in uterine quiescence. Reprod Sci. 2011 Aug;18(8):781-97.
• [410] Stem cell transcriptome responses and corresponding biomarkers that indicate the transition from adaptive responses to cytotoxicity. Chem Res Toxicol. 2017 Apr 17;30(4):905-922.
• [411] Proteomic analysis of antiproliferative effects by treatment of 5-fluorouracil in cervical cancer cells. DNA Cell Biol. 2004 Nov;23(11):769-76.
• [412] Association of the histidine-triad nucleotide-binding protein-1 (HINT1) gene variants with nicotine dependence. Pharmacogenomics J. 2011 Aug;11(4):251-7. doi: 10.1038/tpj.2010.41. Epub 2010 Jun 1.
• [413] Activation of protein kinase G Increases the expression of p21CIP1, p27KIP1, and histidine triad protein 1 through Sp1. Cancer Res. 2008 Jul 1;68(13):5355-62.
• [414] Rosiglitazone, an Agonist of PPARgamma, Inhibits Non-Small Cell Carcinoma Cell Proliferation In Part through Activation of Tumor Sclerosis Complex-2. PPAR Res. 2007;2007:29632. doi: 10.1155/2007/29632.
• [415] Involvement of C/EBP-related signaling pathway in methamphetamine-induced neuronal autophagy and apoptosis. Toxicol Lett. 2019 Sep 15;312:11-21. doi: 10.1016/j.toxlet.2019.05.003. Epub 2019 May 3.
• [416] Aberrant expression of TSC2 gene in the newly diagnosed acute leukemia. Leuk Res. 2009 Jul;33(7):891-7. doi: 10.1016/j.leukres.2009.01.041. Epub 2009 Feb 27.
• [417] Effects and mechanisms of betulinic acid on improving EGFR TKI-resistance of lung cancer cells. Environ Toxicol. 2018 Nov;33(11):1153-1159.
• [418] The protective effects of liraglutide on AD-like neurodegeneration induced by oxidative stress in human neuroblastoma SH-SY5Y cells. Chem Biol Interact. 2019 Sep 1;310:108688. doi: 10.1016/j.cbi.2019.06.001. Epub 2019 Jun 4.
• [419] Dysregulation of integrin-linked kinase (ILK) signaling in colonic polyposis. Oncogene. 2001 Sep 27;20(43):6250-7. doi: 10.1038/sj.onc.1204791.
• [420] Differential effects of simvastatin and pravastatin on expression of Alzheimer's disease-related genes in human astrocytes and neuronal cells. J Lipid Res. 2009 Oct;50(10):2095-102. doi: 10.1194/jlr.M900236-JLR200. Epub 2009 May 21.
• [421] Suppression of NF-kappaB and GSK-3beta is involved in colon cancer cell growth inhibition by the PPAR agonist troglitazone. Chem Biol Interact. 2010 Oct 6;188(1):75-85. doi: 10.1016/j.cbi.2010.06.001. Epub 2010 Jun 9.
• [422] NGBR is required to ameliorate type 2 diabetes in mice by enhancing insulin sensitivity. J Biol Chem. 2021 Jan-Jun;296:100624. doi: 10.1016/j.jbc.2021.100624. Epub 2021 Apr 2.
• [423] Retinoic acid and its 4-oxo metabolites are functionally active in human skin cells in vitro. J Invest Dermatol. 2005 Jul;125(1):143-53.
• [424] Novel carbocyclic curcumin analog CUR3d modulates genes involved in multiple apoptosis pathways in human hepatocellular carcinoma cells. Chem Biol Interact. 2015 Dec 5;242:107-22.
• [425] Elucidating progesterone effects in breast cancer: cross talk with PDGF signaling pathway in smooth muscle cell. J Cell Biochem. 2007 Jan 1;100(1):174-83. doi: 10.1002/jcb.21045.
• [426] Using a customized DNA microarray for expression profiling of the estrogen-responsive genes to evaluate estrogen activity among natural estrogens and industrial chemicals. Environ Health Perspect. 2004 May;112(7):773-81. doi: 10.1289/ehp.6753.
• [427] [Differential proteomic expression in human liver cells stimulated by hydroquinone]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2006 Nov;24(11):658-61.
• [428] Effect of zoledronic acid on oral fibroblasts and epithelial cells: a potential mechanism of bisphosphonate-associated osteonecrosis. Br J Haematol. 2009 Mar;144(5):667-76. doi: 10.1111/j.1365-2141.2008.07504.x. Epub 2008 Nov 20.
• [429] Transcriptional repression of IKK by p53 in arsenite-induced GADD45 accumulation and apoptosis. Oncogene. 2019 Jan;38(5):731-746. doi: 10.1038/s41388-018-0478-7. Epub 2018 Sep 3.
• [430] Up-regulation of telomere-binding TRF1, TRF2 related to reactive oxygen species induced by As(2)O(3) in MGC-803 cells. Eur J Pharmacol. 2005 May 23;516(1):1-9. doi: 10.1016/j.ejphar.2005.04.022.
• [431] Resveratrol induces senescence-like growth inhibition of U-2 OS cells associated with the instability of telomeric DNA and upregulation of BRCA1. Mech Ageing Dev. 2009 Aug;130(8):528-37. doi: 10.1016/j.mad.2009.06.005. Epub 2009 Jun 25.
• [432] Survival of retinal pigment epithelium after exposure to prolonged oxidative injury: a detailed gene expression and cellular analysis. Invest Ophthalmol Vis Sci. 2004 Oct;45(10):3767-77.
• [433] JunD is involved in the antiproliferative effect of Delta9-tetrahydrocannabinol on human breast cancer cells. Oncogene. 2008 Aug 28;27(37):5033-44.
• [434] Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses. PLoS One. 2010 Dec 17;5(12):e14352. doi: 10.1371/journal.pone.0014352.
• [435] Differentially expressed genes in the prostate cancer cell line LNCaP after exposure to androgen and anti-androgen. Cancer Genet Cytogenet. 2006 Apr 15;166(2):130-8. doi: 10.1016/j.cancergencyto.2005.09.012.
• [436] p19INK4D and cell death. Cell Cycle. 2006 Mar;5(6):596-8. doi: 10.4161/cc.5.6.2585. Epub 2006 Mar 15.
• [437] Simvastatin inhibits cell growth and induces apoptosis and G0/G1 cell cycle arrest in hepatic cancer cells. Int J Mol Med. 2010 Nov;26(5):735-41. doi: 10.3892/ijmm_00000520.
• [438] Systems analysis of transcriptome and proteome in retinoic acid/arsenic trioxide-induced cell differentiation/apoptosis of promyelocytic leukemia. Proc Natl Acad Sci U S A. 2005 May 24;102(21):7653-8.
• [439] A genomic approach to predict synergistic combinations for breast cancer treatment. Pharmacogenomics J. 2013 Feb;13(1):94-104. doi: 10.1038/tpj.2011.48. Epub 2011 Nov 15.
• [440] Role of HER-2/neu signaling in sensitivity to tumor necrosis factor-related apoptosis-inducing ligand: enhancement of TRAIL-mediated apoptosis by amiloride. J Cell Biochem. 2005 Oct 1;96(2):376-89. doi: 10.1002/jcb.20512.
• [441] Proteomic profile of aminoglutethimide-induced apoptosis in HL-60 cells: role of myeloperoxidase and arylamine free radicals. Chem Biol Interact. 2015 Sep 5;239:129-38.
• [442] Proteomics investigations of drug-induced hepatotoxicity in HepG2 cells. Toxicol Sci. 2011 Mar;120(1):109-22.
• [443] Proteomic analysis of human adipose tissue after rosiglitazone treatment shows coordinated changes to promote glucose uptake. Obesity (Silver Spring). 2010 Jan;18(1):27-34. doi: 10.1038/oby.2009.208. Epub 2009 Jun 25.
• [444] Zoledronate dysregulates fatty acid metabolism in renal tubular epithelial cells to induce nephrotoxicity. Arch Toxicol. 2018 Jan;92(1):469-485.
• [445] Cellular response to 5-fluorouracil (5-FU) in 5-FU-resistant colon cancer cell lines during treatment and recovery. Mol Cancer. 2006 May 18;5:20. doi: 10.1186/1476-4598-5-20.
• [446] Gene expression in benzene-exposed workers by microarray analysis of peripheral mononuclear blood cells: induction and silencing of CYP4F3A and regulation of DNA-dependent protein kinase catalytic subunit in DNA double strand break repair. Chem Biol Interact. 2010 Mar 19;184(1-2):207-11.
• [447] Ouabain induces apoptotic cell death in human prostate DU 145 cancer cells through DNA damage and TRAIL pathways. Environ Toxicol. 2019 Dec;34(12):1329-1339. doi: 10.1002/tox.22834. Epub 2019 Aug 21.
• [448] Suppression of breast cancer by chemical modulation of vulnerable zinc fingers in estrogen receptor. Nat Med. 2004 Jan;10(1):40-7. doi: 10.1038/nm969. Epub 2003 Dec 14.
• [449] Estrogen receptor regulates E2F1 expression to mediate tamoxifen resistance. Mol Cancer Res. 2010 Mar;8(3):343-52. doi: 10.1158/1541-7786.MCR-09-0395. Epub 2010 Mar 9.
• [450] Antiproliferative effects of gefitinib are associated with suppression of E2F-1 expression and telomerase activity. Anticancer Res. 2006 Sep-Oct;26(5A):3387-91.
• [451] Molecular characterization of a toxicological tipping point during human stem cell differentiation. Reprod Toxicol. 2020 Jan;91:1-13. doi: 10.1016/j.reprotox.2019.10.001. Epub 2019 Oct 7.
• [452] Epigenetic silencing of novel tumor suppressors in malignant melanoma. Cancer Res. 2006 Dec 1;66(23):11187-93. doi: 10.1158/0008-5472.CAN-06-1274.
• [453] Folic acid supplementation dysregulates gene expression in lymphoblastoid cells--implications in nutrition. Biochem Biophys Res Commun. 2011 Sep 9;412(4):688-92. doi: 10.1016/j.bbrc.2011.08.027. Epub 2011 Aug 16.
• [454] Immediate up-regulation of the calcium-binding protein S100P and its involvement in the cytokinin-induced differentiation of human myeloid leukemia cells. Biochim Biophys Acta. 2005 Sep 10;1745(2):156-65.
• [455] Neuroprotective effects of glucomoringin-isothiocyanate against H(2)O(2)-Induced cytotoxicity in neuroblastoma (SH-SY5Y) cells. Neurotoxicology. 2019 Dec;75:89-104. doi: 10.1016/j.neuro.2019.09.008. Epub 2019 Sep 12.
• [456] Benzodithiophenes potentiate differentiation of acute promyelocytic leukemia cells by lowering the threshold for ligand-mediated corepressor/coactivator exchange with retinoic acid receptor alpha and enhancing changes in all-trans-retinoic acid-regulated gene expression. Cancer Res. 2005 Sep 1;65(17):7856-65. doi: 10.1158/0008-5472.CAN-05-1056.
• [457] Arsenic trioxide down-regulates antiapoptotic genes and induces cell death in mycosis fungoides tumors in a mouse model. Ann Oncol. 2008 Aug;19(8):1488-1494. doi: 10.1093/annonc/mdn056. Epub 2008 Mar 17.
• [458] Targeting activation of specific NF-B subunits prevents stress-dependent atherothrombotic gene expression. Mol Med. 2012 Dec 20;18(1):1375-86. doi: 10.2119/molmed.2012.00282.
• [459] Sulforaphane increases drug-mediated cytotoxicity toward cancer stem-like cells of pancreas and prostate. Mol Ther. 2011 Jan;19(1):188-95.
• [460] Differential expression of microRNAs and their predicted targets in renal cells exposed to amphotericin B and its complex with copper (II) ions. Toxicol Mech Methods. 2017 Sep;27(7):537-543. doi: 10.1080/15376516.2017.1333554. Epub 2017 Jun 8.
• [461] Efficient intervention of growth and infiltration of primary adult T-cell leukemia cells by an HIV protease inhibitor, ritonavir. Blood. 2006 Jan 15;107(2):716-24. doi: 10.1182/blood-2005-02-0735. Epub 2005 Sep 20.
• [462] Estrogen and pure antiestrogen fulvestrant (ICI 182 780) augment cell-matrigel adhesion of MCF-7 breast cancer cells through a novel G protein coupled estrogen receptor (GPR30)-to-calpain signaling axis. Toxicol Appl Pharmacol. 2014 Mar 1;275(2):176-81. doi: 10.1016/j.taap.2014.01.005. Epub 2014 Jan 17.
• [463] Cleavage of focal adhesion kinase is an early marker and modulator of oxidative stress-induced apoptosis. Chem Biol Interact. 2008 Jan 10;171(1):57-66. doi: 10.1016/j.cbi.2007.08.009. Epub 2007 Aug 19.
• [464] Quercetin inhibits migration and invasion of SAS human oral cancer cells through inhibition of NF-B and matrix metalloproteinase-2/-9 signaling pathways. Anticancer Res. 2013 May;33(5):1941-50.
• [465] Activation of cannabinoid receptors promote periodontal cell adhesion and migration. J Clin Periodontol. 2019 Dec;46(12):1264-1272. doi: 10.1111/jcpe.13190. Epub 2019 Oct 22.
• [466] Monomeric and oligomeric flavanols are agonists of membrane androgen receptors. Exp Cell Res. 2005 Oct 1;309(2):329-39. doi: 10.1016/j.yexcr.2005.06.011.
• [467] Disruption of FAK signaling: a side mechanism in cytotoxicity. Toxicology. 2008 Mar 12;245(1-2):1-10. doi: 10.1016/j.tox.2007.12.003. Epub 2007 Dec 15.
• [468] Cannabidiol induces osteoblast differentiation via angiopoietin1 and p38 MAPK. Environ Toxicol. 2020 Dec;35(12):1318-1325. doi: 10.1002/tox.22996. Epub 2020 Jul 13.
• [469] Ethanol impairs intestinal barrier function in humans through mitogen activated protein kinase signaling: a combined in vivo and in vitro approach. PLoS One. 2014 Sep 16;9(9):e107421. doi: 10.1371/journal.pone.0107421. eCollection 2014.
• [470] Hydrocortisone enhances the barrier properties of HBMEC/ci, a brain microvascular endothelial cell line, through mesenchymal-to-endothelial transition-like effects. Fluids Barriers CNS. 2015 Mar 5;12:7. doi: 10.1186/s12987-015-0003-0. eCollection 2015.
• [471] 4.8% sevoflurane induces activation of autophagy in human neuroblastoma SH-SY5Y cells by the AMPK/mTOR signaling pathway. Neurotoxicology. 2022 May;90:256-264. doi: 10.1016/j.neuro.2022.04.008. Epub 2022 Apr 23.
• [472] Neurokinin-1 receptor (NK1R) inhibition sensitizes APL cells to anti-tumor effect of arsenic trioxide via restriction of NF-B axis: Shedding new light on resistance to Aprepitant. Int J Biochem Cell Biol. 2018 Oct;103:105-114. doi: 10.1016/j.biocel.2018.08.010. Epub 2018 Aug 23.
• [473] Verapamil potentiates anti-glioblastoma efficacy of temozolomide by modulating apoptotic signaling. Toxicol In Vitro. 2018 Oct;52:306-313. doi: 10.1016/j.tiv.2018.07.001. Epub 2018 Jul 9.
• [474] Effects of gonadotrophin-releasing hormone agonists on apoptosis of granulosa cells. Ann N Y Acad Sci. 2005 May;1042:531-7. doi: 10.1196/annals.1338.065.
• [475] BMN 673 (talazoparib): A potent PARP inhibitor for triple negative breast cancer with different genetic profile. J Biochem Mol Toxicol. 2019 May;33(5):e22286. doi: 10.1002/jbt.22286. Epub 2019 Jan 23.
• [476] Combining kallistatin gene therapy and meloxicam to treat hepatocellular carcinoma in mice. Cancer Sci. 2009 Nov;100(11):2226-33. doi: 10.1111/j.1349-7006.2009.01306.x. Epub 2009 Aug 4.
• [477] Ciprofloxacin mediated cell growth inhibition, S/G2-M cell cycle arrest, and apoptosis in a human transitional cell carcinoma of the bladder cell line. Clin Cancer Res. 2000 Mar;6(3):891-900.
• [478] Role of miRNA in the regulation of cannabidiol-mediated apoptosis in neuroblastoma cells. Oncotarget. 2019 Jan 1;10(1):45-59. doi: 10.18632/oncotarget.26534. eCollection 2019 Jan 1.
• [479] Expression of the retinoic acid-metabolizing enzyme CYP26A1 limits programmed cell death. Mol Pharmacol. 2005 May;67(5):1808-17. doi: 10.1124/mol.104.005769. Epub 2005 Feb 9.
• [480] Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53. Cancer Res. 2004 May 1;64(9):3022-9. doi: 10.1158/0008-5472.can-03-1880.
• [481] Role of BAX in the apoptotic response to anticancer agents. Science. 2000 Nov 3;290(5493):989-92. doi: 10.1126/science.290.5493.989.
• [482] Mechanisms of thymidine kinase/ganciclovir and cytosine deaminase/ 5-fluorocytosine suicide gene therapy-induced cell death in glioma cells. Oncogene. 2005 Feb 10;24(7):1231-43. doi: 10.1038/sj.onc.1208290.
• [483] Simvastatin induces apoptosis in human colon cancer cells and in tumor xenografts, and attenuates colitis-associated colon cancer in mice. Int J Cancer. 2008 Aug 15;123(4):951-7. doi: 10.1002/ijc.23593.
• [484] Arsenic trioxide initiates ER stress responses, perturbs calcium signalling and promotes apoptosis in human lens epithelial cells. Exp Eye Res. 2007 Dec;85(6):825-35. doi: 10.1016/j.exer.2007.08.018. Epub 2007 Aug 29.
• [485] Rb2/p130 and protein phosphatase 2A: key mediators of ovarian carcinoma cell growth suppression by all-trans retinoic acid. Oncogene. 2006 Aug 28;25(38):5315-25. doi: 10.1038/sj.onc.1209679.
• [486] Retinoblastoma protein and CCAAT/enhancer-binding protein beta are required for 1,25-dihydroxyvitamin D3-induced monocytic differentiation of HL60 cells. Cancer Res. 2004 Jan 1;64(1):370-7. doi: 10.1158/0008-5472.can-03-3029.
• [487] Dual inhibition of CDK4/Rb and PI3K/AKT/mTOR pathways by ON123300 induces synthetic lethality in mantle cell lymphomas. Leukemia. 2016 Jan;30(1):86-93. doi: 10.1038/leu.2015.185. Epub 2015 Jul 15.
• [488] mTOR inhibition reverses acquired endocrine therapy resistance of breast cancer cells at the cell proliferation and gene-expression levels. Cancer Sci. 2008 Oct;99(10):1992-2003. doi: 10.1111/j.1349-7006.2008.00955.x.
• [489] [Effects of Arsenic Trioxide on Cdc20 and Mad2 in Acute Myeloid Leukemia HL-60 Cell Line]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2018 Jun;26(3):710-715. doi: 10.7534/j.issn.1009-2137.2018.03.013.
• [490] Mithramycin inhibits human epithelial carcinoma cell proliferation and migration involving downregulation of Eps8 expression. Chem Biol Interact. 2010 Jan 5;183(1):181-6. doi: 10.1016/j.cbi.2009.09.018.
• [491] Impairment of hypoxia-induced HIF-1 signaling in keratinocytes and fibroblasts by sulfur mustard is counteracted by a selective PHD-2 inhibitor. Arch Toxicol. 2016 May;90(5):1141-50. doi: 10.1007/s00204-015-1549-y. Epub 2015 Jun 17.
• [492] Arsenic trioxide induces autophagic cell death in malignant glioma cells by upregulation of mitochondrial cell death protein BNIP3. Oncogene. 2005 Feb 3;24(6):980-91. doi: 10.1038/sj.onc.1208095.
• [493] Transcriptional profiling of lactic acid treated reconstructed human epidermis reveals pathways underlying stinging and itch. Toxicol In Vitro. 2019 Jun;57:164-173.
• [494] Gene expression changes in primary human nasal epithelial cells exposed to formaldehyde in vitro. Toxicol Lett. 2010 Oct 5;198(2):289-95.
• [495] Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma. Oncotarget. 2014 May 15;5(9):2355-71.
• [496] Pleiotropic combinatorial transcriptomes of human breast cancer cells exposed to mixtures of dietary phytoestrogens. Food Chem Toxicol. 2009 Apr;47(4):787-95.
• [497] Hesperidin delays cell cycle progression into the G0/G1 phase via suspension of MAPK signaling pathway in intrahepatic cholangiocarcinoma. J Biochem Mol Toxicol. 2022 Apr;36(4):e22981. doi: 10.1002/jbt.22981. Epub 2022 Jan 4.
• [498] 17-Estradiol Activates HSF1 via MAPK Signaling in ER-Positive Breast Cancer Cells. Cancers (Basel). 2019 Oct 11;11(10):1533. doi: 10.3390/cancers11101533.
• [499] Ursodeoxycholic acid but not tauroursodeoxycholic acid inhibits proliferation and differentiation of human subcutaneous adipocytes. PLoS One. 2013 Dec 3;8(12):e82086. doi: 10.1371/journal.pone.0082086. eCollection 2013.
• [500] Selenium binding protein 1 in ovarian cancer. Int J Cancer. 2006 May 15;118(10):2433-40. doi: 10.1002/ijc.21671.
• [501] Involvement of mitochondrial dysfunction in nefazodone-induced hepatotoxicity. Food Chem Toxicol. 2016 Aug;94:148-58. doi: 10.1016/j.fct.2016.06.001. Epub 2016 Jun 8.
• [502] Targeting of EGFR increase?anti-cancer effects of arsenic trioxide: Promising treatment for glioblastoma multiform. Eur J Pharmacol. 2018 Feb 5;820:274-285. doi: 10.1016/j.ejphar.2017.12.041. Epub 2017 Dec 20.
• [503] Aspirin and alterations in DNA repair proteins in the SW480 colorectal cancer cell line. Oncol Rep. 2010 Jul;24(1):37-46. doi: 10.3892/or_00000826.
• [504] An ATM- and Rad3-related (ATR) signaling pathway and a phosphorylation-acetylation cascade are involved in activation of p53/p21Waf1/Cip1 in response to 5-aza-2'-deoxycytidine treatment. J Biol Chem. 2008 Feb 1;283(5):2564-74. doi: 10.1074/jbc.M702454200. Epub 2007 Oct 31.
• [505] Drinking-water arsenic exposure modulates gene expression in human lymphocytes from a U.S. population. Environ Health Perspect. 2008 Apr;116(4):524-31. doi: 10.1289/ehp.10861.
• [506] Gene expression in endometrial cancer cells (Ishikawa) after short time high dose exposure to progesterone. Steroids. 2008 Jan;73(1):116-28.
• [507] AS3MT facilitates NLRP3 inflammasome activation by m(6)A modification during arsenic-induced hepatic insulin resistance. Cell Biol Toxicol. 2023 Oct;39(5):2165-2181. doi: 10.1007/s10565-022-09703-7. Epub 2022 Feb 28.
• [508] Hydroquinone triggers pyroptosis and endoplasmic reticulum stress via AhR-regulated oxidative stress in human lymphocytes. Toxicol Lett. 2023 Mar 1;376:39-50. doi: 10.1016/j.toxlet.2023.01.005. Epub 2023 Jan 13.
• [509] Cimetidine induces interleukin-18 production through H2-agonist activity in monocytes. Mol Pharmacol. 2006 Aug;70(2):450-3. doi: 10.1124/mol.106.025890. Epub 2006 May 24.
• [510] Dihydroartemisinin induces pyroptosis by promoting the AIM2/caspase-3/DFNA5 axis in breast cancer cells. Chem Biol Interact. 2021 May 1;340:109434. doi: 10.1016/j.cbi.2021.109434. Epub 2021 Mar 6.
• [511] Cytoskeletal activation and altered gene expression in endothelial barrier regulation by simvastatin. Am J Respir Cell Mol Biol. 2004 May;30(5):662-70. doi: 10.1165/rcmb.2003-0267OC. Epub 2003 Nov 20.
• [512] Gene expression in human hippocampus from cocaine abusers identifies genes which regulate extracellular matrix remodeling. PLoS One. 2007 Nov 14;2(11):e1187. doi: 10.1371/journal.pone.0001187.
• [513] Chronic exposure to arsenic causes increased cell survival, DNA damage, and increased expression of mitochondrial transcription factor A (mtTFA) in human prostate epithelial cells. Chem Res Toxicol. 2011 Mar 21;24(3):340-9. doi: 10.1021/tx1003112. Epub 2011 Jan 14.
• [514] Natural antioxidants exhibit chemopreventive characteristics through the regulation of CNC b-Zip transcription factors in estrogen-induced breast carcinogenesis. J Biochem Mol Toxicol. 2014 Dec;28(12):529-38.
• [515] Statins activate the mitochondrial pathway of apoptosis in human lymphoblasts and myeloma cells. Carcinogenesis. 2005 May;26(5):883-91. doi: 10.1093/carcin/bgi036. Epub 2005 Feb 10.
• [516] Drug-induced caspase 8 upregulation sensitises cisplatin-resistant ovarian carcinoma cells to rhTRAIL-induced apoptosis. Br J Cancer. 2011 Apr 12;104(8):1278-87. doi: 10.1038/bjc.2011.84.
• [517] Essential role of caspase-8 in p53/p73-dependent apoptosis induced by etoposide in head and neck carcinoma cells. Mol Cancer. 2011 Jul 31;10:95. doi: 10.1186/1476-4598-10-95.
• [518] The anti-cancer drug gefitinib accelerates Fas-mediated apoptosis by enhancing caspase-8 activation in cancer cells. J Toxicol Sci. 2019;44(6):435-440. doi: 10.2131/jts.44.435.
• [519] Melatonin enhances hydrogen peroxide-induced apoptosis in human promyelocytic leukaemia HL-60 cells. Mol Cell Biochem. 2011 Jul;353(1-2):167-76. doi: 10.1007/s11010-011-0783-8. Epub 2011 Mar 23.
• [520] Ciprofloxacin induces apoptosis and inhibits proliferation of human colorectal carcinoma cells. Br J Cancer. 2002 Feb 1;86(3):443-8. doi: 10.1038/sj.bjc.6600079.
• [521] DNA methylation inhibits p53-mediated survivin repression. Oncogene. 2009 May 14;28(19):2046-50. doi: 10.1038/onc.2009.62. Epub 2009 Apr 13.
• [522] Identification of HMG-CoA reductase inhibitors as activators for human, mouse and rat constitutive androstane receptor. Drug Metab Dispos. 2005 Jul;33(7):924-9.
• [523] Bioactive terpenoids and flavonoids from Ginkgo biloba extract induce the expression of hepatic drug-metabolizing enzymes through pregnane X receptor, constitutive androstane receptor, and aryl hydrocarbon receptor-mediated pathways. Pharm Res. 2009 Apr;26(4):872-82.
• [524] Species-specific toxicity of diclofenac and troglitazone in primary human and rat hepatocytes. Chem Biol Interact. 2009 Apr 15;179(1):17-24.
• [525] Fetal bovine serum and human constitutive androstane receptor: evidence for activation of the SV23 splice variant by artemisinin, artemether, and arteether in a serum-free cell culture system. Toxicol Appl Pharmacol. 2014 Jun 1;277(2):221-30. doi: 10.1016/j.taap.2014.03.023. Epub 2014 Apr 12.
• [526] Constitutive androstane/active receptor is a target of retinoic acid receptor in humans. Biochem Pharmacol. 2010 Jul 1;80(1):129-35. doi: 10.1016/j.bcp.2010.02.023. Epub 2010 Mar 6.
• [527] Expression and inducibility of cytochrome P450s (CYP1A1, 2B6, 2E1, 3A4) in human cord blood CD34(+) stem cell-derived differentiating neuronal cells. Toxicol Sci. 2012 Oct;129(2):392-410.
• [528] Agonistic effects of diverse xenobiotics on the constitutive androstane receptor as detected in a recombinant yeast-cell assay. Toxicol In Vitro. 2018 Feb;46:335-349. doi: 10.1016/j.tiv.2017.09.014. Epub 2017 Sep 18.
• [529] Teriflunomide is an indirect human constitutive androstane receptor (CAR) activator interacting with epidermal growth factor (EGF) signaling. Front Pharmacol. 2018 Oct 11;9:993.
• [530] New insights into BaP-induced toxicity: role of major metabolites in transcriptomics and contribution to hepatocarcinogenesis. Arch Toxicol. 2016 Jun;90(6):1449-58.
• [531] Linking site-specific loss of histone acetylation to repression of gene expression by the mycotoxin ochratoxin A. Arch Toxicol. 2018 Feb;92(2):995-1014.
• [532] Abeta42-lowering nonsteroidal anti-inflammatory drugs preserve intramembrane cleavage of the amyloid precursor protein (APP) and ErbB-4 receptor and signaling through the APP intracellular domain. J Biol Chem. 2003 Aug 15;278(33):30748-54. doi: 10.1074/jbc.M304824200. Epub 2003 May 31.
• [533] Glucocorticoids inhibit cell death in ovarian cancer and up-regulate caspase inhibitor cIAP2. Clin Cancer Res. 2005 Sep 1;11(17):6325-32. doi: 10.1158/1078-0432.CCR-05-0182.
• [534] The DNA damaging agent VP16 induces the expression of a subset of ligands from the EGF system in bladder cancer cells, whereas none of the four EGF receptors are induced. Mol Cell Biochem. 2004 May;260(1-2):129-35. doi: 10.1023/b:mcbi.0000026063.96267.98.
• [535] Effects of metformin and pioglitazone combination on apoptosis and AMPK/mTOR signaling pathway in human anaplastic thyroid cancer cells. J Biochem Mol Toxicol. 2020 Oct;34(10):e22547. doi: 10.1002/jbt.22547. Epub 2020 Jun 26.
• [536] Extremely low copper concentrations affect gene expression profiles of human prostate epithelial cell lines. Chem Biol Interact. 2010 Oct 6;188(1):214-9.
• [537] Environmental pollutant induced cellular injury is reflected in exosomes from placental explants. Placenta. 2020 Jan 1;89:42-49. doi: 10.1016/j.placenta.2019.10.008. Epub 2019 Oct 17.
• [538] Whole genome mRNA transcriptomics analysis reveals different modes of action of the diarrheic shellfish poisons okadaic acid and dinophysis toxin-1 versus azaspiracid-1 in Caco-2 cells. Toxicol In Vitro. 2018 Feb;46:102-112.
• [539] Time series analysis of oxidative stress response patterns in HepG2: a toxicogenomics approach. Toxicology. 2013 Apr 5;306:24-34.
• [540] Prenatal arsenic exposure and shifts in the newborn proteome: interindividual differences in tumor necrosis factor (TNF)-responsive signaling. Toxicol Sci. 2014 Jun;139(2):328-37. doi: 10.1093/toxsci/kfu053. Epub 2014 Mar 27.
• [541] The role of sirtuin 1 in osteoblastic differentiation in human periodontal ligament cells. J Periodontal Res. 2011 Dec;46(6):712-21. doi: 10.1111/j.1600-0765.2011.01394.x. Epub 2011 Jul 11.
• [542] Gene expression profiling of 30 cancer cell lines predicts resistance towards 11 anticancer drugs at clinically achieved concentrations. Int J Cancer. 2006 Apr 1;118(7):1699-712. doi: 10.1002/ijc.21570.
• [543] Simvastatin inhibits IL-17 secretion by targeting multiple IL-17-regulatory cytokines and by inhibiting the expression of IL-17 transcription factor RORC in CD4+ lymphocytes. J Immunol. 2008 May 15;180(10):6988-96. doi: 10.4049/jimmunol.180.10.6988.
• [544] Characterization of drug-specific signaling between primary human hepatocytes and immune cells. Toxicol Sci. 2017 Jul 1;158(1):76-89.
• [545] Paroxetine modulates immune responses by activating a JAK2/STAT3 signaling pathway. J Biochem Mol Toxicol. 2020 May;34(5):e22464. doi: 10.1002/jbt.22464. Epub 2020 Feb 5.
• [546] [As(2)O(3) Up-Regulates the Proportion of CD4(+)CD25(+)CD127(low) Tregs in Peripheral Blood of Patients with Severe Aplastic Anemia]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2018 Jun;26(3):854-858. doi: 10.7534/j.issn.1009-2137.2018.03.037.
• [547] Regulatory T cell function correlates with serum 25-hydroxyvitamin D, but not with 1,25-dihydroxyvitamin D, parathyroid hormone and calcium levels in patients with relapsing remitting multiple sclerosis. J Steroid Biochem Mol Biol. 2010 Jul;121(1-2):243-6. doi: 10.1016/j.jsbmb.2010.03.001. Epub 2010 Mar 6.
• [548] Role of N6-methyladenosine RNA modification in the imbalanced inflammatory homeostasis of arsenic-induced skin lesions. Environ Toxicol. 2022 Aug;37(8):1831-1839. doi: 10.1002/tox.23530. Epub 2022 Apr 1.
• [549] IL-13 and IL-17A gene polymorphisms in Japanese patients with aspirin-exacerbated respiratory disease. Ann Allergy Asthma Immunol. 2011 Dec;107(6):510-6. doi: 10.1016/j.anai.2011.09.003. Epub 2011 Sep 22.
• [550] Grape resveratrol increases serum adiponectin and downregulates inflammatory genes in peripheral blood mononuclear cells: a triple-blind, placebo-controlled, one-year clinical trial in patients with stable coronary artery disease. Cardiovasc Drugs Ther. 2013 Feb;27(1):37-48. doi: 10.1007/s10557-012-6427-8.
• [551] Association of CYP1A1 and CYP1B1 inhibition in in vitro assays with drug-induced liver injury. J Toxicol Sci. 2021;46(4):167-176. doi: 10.2131/jts.46.167.
• [552] Convergent transcriptional profiles induced by endogenous estrogen and distinct xenoestrogens in breast cancer cells. Carcinogenesis. 2006 Aug;27(8):1567-78.
• [553] In vitro aromatic bioactivation of the weak estrogen E(2)alpha and genesis of DNA adducts. Steroids. 2005 Mar;70(3):161-72. doi: 10.1016/j.steroids.2004.11.004.
• [554] Metabolism of melatonin by human cytochromes p450. Drug Metab Dispos. 2005 Apr;33(4):489-94.
• [555] Metabolism of retinoids and arachidonic acid by human and mouse cytochrome P450 1b1. Drug Metab Dispos. 2004 Aug;32(8):840-7.
• [556] Apoptosis contributes to the cytotoxicity induced by amodiaquine and its major metabolite N-desethylamodiaquine in hepatic cells. Toxicol In Vitro. 2020 Feb;62:104669. doi: 10.1016/j.tiv.2019.104669. Epub 2019 Oct 16.
• [557] Genetic variants contributing to daunorubicin-induced cytotoxicity. Cancer Res. 2008 May 1;68(9):3161-8. doi: 10.1158/0008-5472.CAN-07-6381.
• [558] Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells. Nat Commun. 2018 Aug 9;9(1):3069. doi: 10.1038/s41467-018-05402-2.
• [559] Cytosine arabinoside induces ectoderm and inhibits mesoderm expression in human embryonic stem cells during multilineage differentiation. Br J Pharmacol. 2011 Apr;162(8):1743-56.
• [560] Resveratrol induces apoptosis and alters gene expression in human fibrosarcoma cells. Anticancer Res. 2015 Feb;35(2):767-74.
• [561] Molecular mechanisms of quercitrin-induced apoptosis in non-small cell lung cancer. Arch Med Res. 2014 Aug;45(6):445-54.
• [562] Effects of Imatinib Mesylate (Gleevec) on human islet NF-kappaB activation and chemokine production in vitro. PLoS One. 2011;6(9):e24831. doi: 10.1371/journal.pone.0024831. Epub 2011 Sep 14.
• [563] Analysis of the in vitro synergistic effect of 5-fluorouracil and cisplatin on cervical carcinoma cells. Int J Gynecol Cancer. 2006 May-Jun;16(3):1321-9.
• [564] Gene expression profile induced by arsenic trioxide in chronic lymphocytic leukemia cells reveals a central role for heme oxygenase-1 in apoptosis and regulation of matrix metalloproteinase-9. Oncotarget. 2016 Dec 13;7(50):83359-83377.
• [565] Susceptibility to drug-induced apoptosis correlates with differential modulation of Bad, Bcl-2 and Bcl-xL protein levels. Cell Death Differ. 2000 Jun;7(6):574-86. doi: 10.1038/sj.cdd.4400688.
• [566] Sulindac sulfide inhibits epidermal growth factor-induced phosphorylation of extracellular-regulated kinase 1/2 and Bad in human colon cancer cells. Cancer Res. 2003 Feb 1;63(3):616-20.
• [567] Simvastatin induces activation of the serine-threonine protein kinase AKT and increases survival of isolated human pancreatic islets. Transplantation. 2002 Oct 27;74(8):1063-9. doi: 10.1097/00007890-200210270-00001.
• [568] Quercetin regulates insulin like growth factor signaling and induces intrinsic and extrinsic pathway mediated apoptosis in androgen independent prostate cancer cells (PC-3). Mol Cell Biochem. 2010 Nov;344(1-2):173-84. doi: 10.1007/s11010-010-0540-4. Epub 2010 Jul 25.
• [569] Down regulation of N-acetylglucosaminyltransferase V facilitates all-transretinoic acid to induce apoptosis of human hepatocarcinoma cells. Mol Cell Biochem. 2006 Mar;284(1-2):103-10. doi: 10.1007/s11010-005-9022-5. Epub 2006 Jan 13.
• [570] Induction of class II major histocompatibility complex expression in human multiple myeloma cells by retinoid. Haematologica. 2007 Jan;92(1):115-20.
• [571] Proteomic and functional analyses reveal a dual molecular mechanism underlying arsenic-induced apoptosis in human multiple myeloma cells. J Proteome Res. 2009 Jun;8(6):3006-19.
• [572] Vanadium-induced HB-EGF expression in human lung fibroblasts is oxidant dependent and requires MAP kinases. Am J Physiol Lung Cell Mol Physiol. 2003 May;284(5):L774-82. doi: 10.1152/ajplung.00189.2002. Epub 2003 Jan 10.
• [573] Osmotic Induction of Angiogenic Growth Factor Expression in Human Retinal Pigment Epithelial Cells. PLoS One. 2016 Jan 22;11(1):e0147312. doi: 10.1371/journal.pone.0147312. eCollection 2016.
• [574] Evaluation of developmental toxicity using undifferentiated human embryonic stem cells. J Appl Toxicol. 2015 Feb;35(2):205-18.
• [575] Resveratrol-induced gene expression profiles in human prostate cancer cells. Cancer Epidemiol Biomarkers Prev. 2005 Mar;14(3):596-604. doi: 10.1158/1055-9965.EPI-04-0398.
• [576] ATR inhibitors VE-821 and VX-970 sensitize cancer cells to topoisomerase i inhibitors by disabling DNA replication initiation and fork elongation responses. Cancer Res. 2014 Dec 1;74(23):6968-79.
• [577] Neurotoxicity and underlying cellular changes of 21 mitochondrial respiratory chain inhibitors. Arch Toxicol. 2021 Feb;95(2):591-615. doi: 10.1007/s00204-020-02970-5. Epub 2021 Jan 29.
• [578] Effect of nephrotoxicants and hepatotoxicants on gene expression profile in human peripheral blood mononuclear cells. Biochem Biophys Res Commun. 2010 Oct 15;401(2):245-50. doi: 10.1016/j.bbrc.2010.09.039. Epub 2010 Sep 16.
• [579] Antiepileptic drugs: impacts on human serum paraoxonase-1. J Biochem Mol Toxicol. 2017 Jun;31(6).
• [580] Beneficial effect of oleoylated lipids on paraoxonase 1: protection against oxidative inactivation and stabilization. Biochem J. 2003 Oct 15;375(Pt 2):275-85.
• [581] Serum paraoxonase activity before and after treatment of thyrotoxicosis. Clin Endocrinol (Oxf). 2004 Jan;60(1):75-80.
• [582] Effects of some antibiotics on paraoxonase from human serum in vitro and from mouse serum and liver in vivo. Biol Pharm Bull. 2006 Aug;29(8):1559-63.
• [583] Simvastatin modulates expression of the PON1 gene and increases serum paraoxonase: a role for sterol regulatory element-binding protein-2. Arterioscler Thromb Vasc Biol. 2003 Nov 1;23(11):2083-9. doi: 10.1161/01.ATV.0000096207.01487.36. Epub 2003 Sep 18.
• [584] Dietary polyphenols increase paraoxonase 1 gene expression by an aryl hydrocarbon receptor-dependent mechanism. Mol Cell Biol. 2004 Jun;24(12):5209-22.
• [585] Transcriptional regulation of human paraoxonase 1 by PXR and GR in human hepatoma cells. Toxicol In Vitro. 2015 Dec 25;30(1 Pt B):348-54.
• [586] Induction of paraoxonase 1 and apolipoprotein A-I gene expression by aspirin. J Lipid Res. 2008 Oct;49(10):2142-8.
• [587] Dexamethasone differentially regulates expression of carboxylesterase genes in humans and rats. Drug Metab Dispos. 2000 Feb;28(2):186-91.
• [588] Transcriptional activation of the carboxylesterase 2 gene by the p53 pathway. Cancer Biol Ther. 2006 Nov;5(11):1450-6.
• [589] Binding and hydrolysis of meperidine by human liver carboxylesterase hCE-1. J Pharmacol Exp Ther. 1999 Jul;290(1):314-8.
• [590] Inhibition of human carboxylesterases hCE1 and hiCE by cholinesterase inhibitors. Chem Biol Interact. 2013 Mar 25;203(1):226-30.
• [591] Photochemotherapeutic agent 8-methoxypsoralen induces cytochrome P450 3A4 and carboxylesterase HCE2: evidence on an involvement of the pregnane X receptor. Toxicol Sci. 2007 Jan;95(1):13-22.
• [592] Hepatoxicity mechanism of cantharidin-induced liver LO2 cells by LC-MS metabolomics combined traditional approaches. Toxicol Lett. 2020 Oct 15;333:49-61. doi: 10.1016/j.toxlet.2020.07.024. Epub 2020 Jul 26.
• [593] Concise prediction models of anticancer efficacy of 8 drugs using expression data from 12 selected genes. Int J Cancer. 2004 Sep 10;111(4):617-26. doi: 10.1002/ijc.20289.
• [594] Human carboxylesterase 1: from drug metabolism to drug discovery. Biochem Soc Trans. 2003 Jun;31(Pt 3):620-4. doi: 10.1042/bst0310620.
• [595] Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine: from binding promiscuity to selective inhibition. Chem Biol. 2003 Apr;10(4):341-9. doi: 10.1016/s1074-5521(03)00071-1.
• [596] Gingival Stromal Cells as an In Vitro Model: Cannabidiol Modulates Genes Linked With Amyotrophic Lateral Sclerosis. J Cell Biochem. 2017 Apr;118(4):819-828. doi: 10.1002/jcb.25757. Epub 2016 Nov 28.
• [597] Protective role of HO-1 for alcohol-dependent liver damage. Dig Dis. 2010;28(6):792-8. doi: 10.1159/000324287. Epub 2011 Apr 27.
• [598] Gypenosides protect retinal pigment epithelium cells from oxidative stress. Food Chem Toxicol. 2018 Feb;112:76-85.
• [599] Distinct Nrf2 Signaling Mechanisms of Fumaric Acid Esters and Their Role in Neuroprotection against 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Experimental Parkinson's-Like Disease. J Neurosci. 2016 Jun 8;36(23):6332-51. doi: 10.1523/JNEUROSCI.0426-16.2016.
• [600] Simvastatin protects dopaminergic neurons against MPP+-induced oxidative stress and regulates the endogenous anti-oxidant system through ERK. Cell Physiol Biochem. 2018;51(4):1957-1968.
• [601] P450 3A-catalyzed O-dealkylation of lapatinib induces mitochondrial stress and activates Nrf2. Chem Res Toxicol. 2016 May 16;29(5):784-96.
• [602] P21(Waf1/Cip1) plays a critical role in furazolidone-induced apoptosis in HepG2 cells through influencing the caspase-3 activation and ROS generation. Food Chem Toxicol. 2016 Feb;88:1-12. doi: 10.1016/j.fct.2015.12.004. Epub 2015 Dec 11.
• [603] Insights into the transcriptional regulation of the anthracycline reductase AKR7A2 in human cardiomyocytes. Toxicol Lett. 2019 Jun 1;307:11-16.
• [604] Increased mitochondrial ROS formation by acetaminophen in human hepatic cells is associated with gene expression changes suggesting disruption of the mitochondrial electron transport chain. Toxicol Lett. 2015 Apr 16;234(2):139-50.
• [605] Inducible protection of human astrocytoma 1321N1 cells against hydrogen peroxide and aldehyde toxicity by 7-hydroxycoumarin is associated with the upregulation of aldo-keto reductases. Neurotoxicology. 2012 Oct;33(5):1368-74.
• [606] Human aldo-keto reductase AKR7A2 protects against the cytotoxicity and mutagenicity of reactive aldehydes and lowers intracellular reactive oxygen species in hamster V79-4 cells. Chem Biol Interact. 2012 Jan 5;195(1):25-34. doi: 10.1016/j.cbi.2011.09.007. Epub 2011 Oct 5.
• [607] Functional cardiotoxicity assessment of cosmetic compounds using human-induced pluripotent stem cell-derived cardiomyocytes. Arch Toxicol. 2018 Jan;92(1):371-381.
• [608] Enhanced cytotoxicity of bioreductive antitumor agents with dimethyl fumarate in human glioblastoma cells. Anticancer Drugs. 2005 Feb;16(2):167-74.
• [609] Growth-suppressive effect of non-steroidal anti-inflammatory drugs on 11 colon-cancer cell lines and fluorescence differential display of genes whose expression is influenced by sulindac. Int J Cancer. 2000 Dec 15;88(6):873-80. doi: 10.1002/1097-0215(20001215)88:6<873::aid-ijc6>3.0.co;2-b.
• [610] Induction of human NAD(P)H:quinone oxidoreductase (NQO1) gene expression by the flavonol quercetin. Toxicol Lett. 2001 Feb 3;119(1):49-57.
• [611] Type 5 17beta-hydroxysteroid dehydrogenase/prostaglandin F synthase (AKR1C3): role in breast cancer and inhibition by non-steroidal anti-inflammatory drug analogs. Chem Biol Interact. 2009 Mar 16;178(1-3):221-7.
• [612] Substrate specificity of human 3(20)alpha-hydroxysteroid dehydrogenase for neurosteroids and its inhibition by benzodiazepines. Biol Pharm Bull. 2002 Apr;25(4):441-5.
• [613] Progestins as inhibitors of the human 20-ketosteroid reductases, AKR1C1 and AKR1C3. Chem Biol Interact. 2011 May 30;191(1-3):227-33.
• [614] In-vivo effects of simvastatin and rosuvastatin on global gene expression in peripheral blood leucocytes in a human inflammation model. Pharmacogenet Genomics. 2008 Feb;18(2):109-20.
• [615] AKR1C3 as a potential target for the inhibitory effect of dietary flavonoids. Chem Biol Interact. 2009 Mar 16;178(1-3):138-44.
• [616] Differential effects of statins on relevant functions of human monocyte-derived dendritic cells. J Leukoc Biol. 2006 Mar;79(3):529-38. doi: 10.1189/jlb.0205064. Epub 2005 Dec 30.
• [617] Quercetin regulates oxidized LDL induced inflammatory changes in human PBMCs by modulating the TLR-NF-B signaling pathway. Immunobiology. 2011 Mar;216(3):367-73. doi: 10.1016/j.imbio.2010.07.011. Epub 2010 Aug 19.
• [618] Mechanical stress-activated immune response genes via Sirtuin 1 expression in human periodontal ligament cells. Clin Exp Immunol. 2012 Apr;168(1):113-24. doi: 10.1111/j.1365-2249.2011.04549.x.
• [619] Primary Human Hepatocyte Spheroids as Tools to Study the Hepatotoxic Potential of Non-Pharmaceutical Chemicals. Int J Mol Sci. 2021 Oct 12;22(20):11005. doi: 10.3390/ijms222011005.
• [620] The role of RelA (p65) threonine 505 phosphorylation in the regulation of cell growth, survival, and migration. Mol Biol Cell. 2011 Sep;22(17):3032-40. doi: 10.1091/mbc.E11-04-0280. Epub 2011 Jul 7.
• [621] Bexarotene activates the p53/p73 pathway in human cutaneous T-cell lymphoma. Br J Dermatol. 2009 Mar;160(3):519-26. doi: 10.1111/j.1365-2133.2008.08931.x. Epub 2008 Nov 25.
• [622] Arsenic trioxide induces apoptosis in NB-4, an acute promyelocytic leukemia cell line, through up-regulation of p73 via suppression of nuclear factor kappa B-mediated inhibition of p73 transcription and prevention of NF-kappaB-mediated induction of XIAP, cIAP2, BCL-XL and survivin. Med Oncol. 2010 Sep;27(3):833-42. doi: 10.1007/s12032-009-9294-9. Epub 2009 Sep 10.
• [623] Differential regulation of vitamin D receptor (VDR) by the p53 Family: p73-dependent induction of VDR upon DNA damage. J Biol Chem. 2007 Oct 12;282(41):29847-54.
• [624] The role of MITF and Mcl-1 proteins in the antiproliferative and proapoptotic effect of ciprofloxacin in amelanotic melanoma cells: In silico and in vitro study. Toxicol In Vitro. 2020 Aug;66:104884. doi: 10.1016/j.tiv.2020.104884. Epub 2020 May 8.
• [625] Melanogenesis and antioxidant defense system in normal human melanocytes cultured in the presence of chlorpromazine. Toxicol In Vitro. 2015 Feb;29(1):221-7.
• [626] PLX4032 Mediated Melanoma Associated Antigen Potentiation in Patient Derived Primary Melanoma Cells. J Cancer. 2015 Oct 29;6(12):1320-30. doi: 10.7150/jca.11126. eCollection 2015.
• [627] Electrophilic components of diesel exhaust particles (DEP) activate transient receptor potential ankyrin-1 (TRPA1): a probable mechanism of acute pulmonary toxicity for DEP. Chem Res Toxicol. 2011 Jun 20;24(6):950-9. doi: 10.1021/tx200123z. Epub 2011 May 25.
• [628] The anthelminthic drug praziquantel is a selective agonist of the sensory transient receptor potential melastatin type 8 channel. Toxicol Appl Pharmacol. 2017 Dec 1;336:55-65. doi: 10.1016/j.taap.2017.10.012. Epub 2017 Oct 18.
• [629] Activation of the human TRPA1 channel by different alkylating sulfur and nitrogen mustards and structurally related chemotherapeutic drugs. Toxicol Lett. 2023 Mar 1;376:51-59. doi: 10.1016/j.toxlet.2023.01.007. Epub 2023 Jan 21.
• [630] Mechanisms and Consequences of Variable TRPA1 Expression by Airway Epithelial Cells: Effects of TRPV1 Genotype and Environmental Agonists on Cellular Responses to Pollutants in Vitro and Asthma. Environ Health Perspect. 2023 Feb;131(2):27009. doi: 10.1289/EHP11076. Epub 2023 Feb 27.
• [631] Time course study of A formation and neurite outgrowth disruption in differentiated human neuroblastoma cells exposed to H2O2: protective role of autophagy. Toxicol In Vitro. 2013 Sep;27(6):1780-8. doi: 10.1016/j.tiv.2013.05.005. Epub 2013 May 29.
• [632] Multitarget effects of quercetin in leukemia. Cancer Prev Res (Phila). 2014 Dec;7(12):1240-50. doi: 10.1158/1940-6207.CAPR-13-0383. Epub 2014 Oct 7.
• [633] Arsenic trioxide induces autophagic cell death in osteosarcoma cells via the ROS-TFEB signaling pathway. Biochem Biophys Res Commun. 2018 Jan 29;496(1):167-175. doi: 10.1016/j.bbrc.2018.01.018. Epub 2018 Jan 4.
• [634] Effects of SIDT2 on the miR-25/NOX4/HuR axis and SIRT3 mRNA stability lead to ROS-mediated TNF- expression in hydroquinone-treated leukemia cells. Cell Biol Toxicol. 2023 Oct;39(5):2207-2225. doi: 10.1007/s10565-022-09705-5. Epub 2022 Mar 18.
• [635] AMPK activation induced by promethazine increases NOXA expression and Beclin-1 phosphorylation and drives autophagy-associated apoptosis in chronic myeloid leukemia. Chem Biol Interact. 2020 Jan 5;315:108888. doi: 10.1016/j.cbi.2019.108888. Epub 2019 Nov 2.
• [636] Endoplasmic reticulum stress contributes to autophagy and apoptosis in cantharidin-induced nephrotoxicity. Food Chem Toxicol. 2022 May;163:112986. doi: 10.1016/j.fct.2022.112986. Epub 2022 Apr 6.
• [637] Adipocyte differentiation, mitochondrial gene expression and fat distribution: differences between zidovudine and tenofovir after 6 months. Antivir Ther. 2009;14(8):1089-100. doi: 10.3851/IMP1457.
• [638] Testosterone stimulates adipose tissue 11beta-hydroxysteroid dehydrogenase type 1 expression in a depot-specific manner in children. J Clin Endocrinol Metab. 2010 Jul;95(7):3300-8.
• [639] Comparison of transcriptome expression alterations by chronic exposure to low-dose bisphenol A in different subtypes of breast cancer cells. Toxicol Appl Pharmacol. 2019 Dec 15;385:114814. doi: 10.1016/j.taap.2019.114814. Epub 2019 Nov 9.
• [640] Genistein disrupts glucocorticoid receptor signaling in human uterine endometrial Ishikawa cells. Environ Health Perspect. 2015 Jan;123(1):80-7. doi: 10.1289/ehp.1408437. Epub 2014 Aug 19.
• [641] Steroid profiling in H295R cells to identify chemicals potentially disrupting the production of adrenal steroids. Toxicology. 2017 Apr 15;381:51-63.
• [642] Influences of norepinephrine transporter function on the distribution of sympathetic activity in humans. Hypertension. 2006 Jul;48(1):120-6. doi: 10.1161/01.HYP.0000225424.13138.5d. Epub 2006 May 22.
• [643] Amiloride, spironolactone, and potassium chloride in thiazide-treated hypertensive patients. Clin Pharmacol Ther. 1980 Apr;27(4):533-43. doi: 10.1038/clpt.1980.75.
• [644] Simvastatin treatment in subjects at high cardiovascular risk modulates AT1R expression on circulating monocytes and T lymphocytes. J Hypertens. 2008 Jun;26(6):1147-55. doi: 10.1097/HJH.0b013e3282f97dde.
• [645] Inhibition of cGMP-specific phosphodiesterase type 5 reduces sodium excretion and arterial blood pressure in patients with NaCl retention and ascites. Am J Physiol Renal Physiol. 2005 May;288(5):F1044-52. doi: 10.1152/ajprenal.00142.2004. Epub 2004 Dec 21.
• [646] Effects of lisinopril on cardiorespiratory, neuroendocrine, and renal function in patients with asymptomatic left ventricular dysfunction. Br Heart J. 1993 Jun;69(6):512-5. doi: 10.1136/hrt.69.6.512.
• [647] Angiotensin II receptor blockade in normotensive subjects: A direct comparison of three AT1 receptor antagonists. Hypertension. 1999 Mar;33(3):850-5. doi: 10.1161/01.hyp.33.3.850.
• [648] Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1. FASEB J. 2012 Apr;26(4):1535-48. doi: 10.1096/fj.11-198184. Epub 2011 Dec 23.
• [649] Discovery of molecular mechanisms of neuroprotection using cell-based bioassays and oligonucleotide arrays. Physiol Genomics. 2002 Oct 29;11(2):45-52. doi: 10.1152/physiolgenomics.00064.2002.
• [650] Inhibition of invasion and induction of apoptosis by selenium in human malignant brain tumour cells in vitro. Int J Oncol. 2007 May;30(5):1263-71.
• [651] Dietary supplementation with the anti-tumour promoter quercetin: its effects on matrix metalloproteinase gene regulation. Mutat Res. 2001 Sep 1;480-481:269-76. doi: 10.1016/s0027-5107(01)00184-1.
• [652] Arsenic trioxide (As2O3) inhibits invasion of HT1080 human fibrosarcoma cells: role of nuclear factor-kappaB and reactive oxygen species. J Cell Biochem. 2005 Aug 1;95(5):955-69. doi: 10.1002/jcb.20452.
• [653] Aspirin inhibits MMP-2 and MMP-9 expressions and activities through upregulation of PPARalpha/gamma and TIMP gene expressions in ox-LDL-stimulated macrophages derived from human monocytes. Pharmacology. 2009;83(1):18-25. doi: 10.1159/000166183. Epub 2008 Oct 30.
• [654] Investigation of in vitro odonto/osteogenic capacity of cannabidiol on human dental pulp cell. J Dent. 2021 Jun;109:103673. doi: 10.1016/j.jdent.2021.103673. Epub 2021 Apr 16.
• [655] Protective effects of myricitrin against osteoporosis via reducing reactive oxygen species and bone-resorbing cytokines. Toxicol Appl Pharmacol. 2014 Nov 1;280(3):550-60.
• [656] Acinar cell-specific knockout of the PTHrP gene decreases the proinflammatory and profibrotic responses in pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2014 Sep 1;307(5):G533-49. doi: 10.1152/ajpgi.00428.2013. Epub 2014 Jul 17.
• [657] The effects of particulate wear debris, cytokines, and growth factors on the functions of MG-63 osteoblasts. J Bone Joint Surg Am. 2001 Feb;83(2):201-11. doi: 10.2106/00004623-200102000-00007.
• [658] Inhibition of systemic sclerosis dermal fibroblast type I collagen production and gene expression by simvastatin. Arthritis Rheum. 2006 Apr;54(4):1298-308. doi: 10.1002/art.21723.
• [659] Antifibrotic effects of quercetin in primary orbital fibroblasts and orbital fat tissue cultures of Graves' orbitopathy. Invest Ophthalmol Vis Sci. 2012 Aug 31;53(9):5921-9. doi: 10.1167/iovs.12-9646.
• [660] Simvastatin, an HMG-CoA reductase inhibitor, induces the synthesis and secretion of apolipoprotein AI in HepG2 cells and primary hamster hepatocytes. Atherosclerosis. 2002 Jul;163(1):59-68. doi: 10.1016/s0021-9150(01)00754-7.
• [661] Quercetin represses apolipoprotein B expression by inhibiting the transcriptional activity of C/EBP. PLoS One. 2015 Apr 15;10(4):e0121784. doi: 10.1371/journal.pone.0121784. eCollection 2015.
• [662] Effect of glucosamine on apolipoprotein AI mRNA stabilization and expression in HepG2 cells. Metabolism. 2004 Jun;53(6):766-71. doi: 10.1016/j.metabol.2003.11.027.
• [663] The effects of clonidine hydrochloride versus atenolol monotherapy on serum lipids, lipid subfractions, and apolipoproteins in mild hypertension. Am Heart J. 1990 Jul;120(1):172-9. doi: 10.1016/0002-8703(90)90175-w.
• [664] Hepatic apolipoprotein A-I gene expression in patients with cholesterol gallstones treated with ursodeoxycholic acid. Ann Hepatol. 2002 Apr-Jun;1(2):85-9.
• [665] Oxidative Stress-Protective and Anti-Melanogenic Effects of Loliolide and Ethanol Extract from Fresh Water Green Algae, Prasiola japonica. Int J Mol Sci. 2018 Sep 18;19(9):2825. doi: 10.3390/ijms19092825.
• [666] The effects of a novel synthetic retinoid, seletinoid G, on the expression of extracellular matrix proteins in aged human skin in vivo. Clin Chim Acta. 2005 Dec;362(1-2):161-9. doi: 10.1016/j.cccn.2005.06.016. Epub 2005 Aug 1.
• [667] Ciprofloxacin enhances the stimulation of matrix metalloproteinase 3 expression by interleukin-1beta in human tendon-derived cells. A potential mechanism of fluoroquinolone-induced tendinopathy. Arthritis Rheum. 2002 Nov;46(11):3034-40. doi: 10.1002/art.10617.
• [668] Simvastatin reduces MMP1 expression in human smooth muscle cells cultured on polymerized collagen by inhibiting Rac1 activation. Arterioscler Thromb Vasc Biol. 2007 May;27(5):1043-9. doi: 10.1161/ATVBAHA.107.139881. Epub 2007 Feb 15.
• [669] Quercetin inhibits matrix metalloproteinase-1 expression in human vascular endothelial cells through extracellular signal-regulated kinase. Arch Biochem Biophys. 2001 Jul 1;391(1):72-8. doi: 10.1006/abbi.2001.2402.
• [670] Rofecoxib regulates the expression of genes related to the matrix metalloproteinase pathway in humans: implication for the adverse effects of cyclooxygenase-2 inhibitors. Clin Pharmacol Ther. 2006 Apr;79(4):303-15. doi: 10.1016/j.clpt.2005.12.306.
• [671] Interaction between the aryl hydrocarbon receptor and retinoic acid pathways increases matrix metalloproteinase-1 expression in keratinocytes. J Biol Chem. 2004 Jun 11;279(24):25284-93. doi: 10.1074/jbc.M402168200. Epub 2004 Apr 9.
• [672] Epinephrine upregulates superoxide dismutase in human coronary artery endothelial cells. Free Radic Biol Med. 2001 Jan 15;30(2):148-53.
• [673] Cissus quadrangularis ethanol extract upregulates superoxide dismutase, glutathione peroxidase and endothelial nitric oxide synthase expression in hydrogen peroxide-injured human ECV304 cells. J Ethnopharmacol. 2012 Sep 28;143(2):664-72.
• [674] Manganese superoxide dismutase is a promising target for enhancing chemosensitivity of basal-like breast carcinoma. Antioxid Redox Signal. 2014 May 20;20(15):2326-46. doi: 10.1089/ars.2013.5295. Epub 2013 Nov 14.
• [675] Effect of retinoic acid on gene expression in human conjunctival epithelium: secretory phospholipase A2 mediates retinoic acid induction of MUC16. Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4050-61.
• [676] p53-R175H mutant gains new function in regulation of doxorubicin-induced apoptosis. Int J Cancer. 2005 Apr 10;114(3):331-6. doi: 10.1002/ijc.20818.
• [677] Azidothymidine and cisplatin increase p14ARF expression in OVCAR-3 ovarian cancer cell line. Toxicol Appl Pharmacol. 2006 Oct 1;216(1):89-97. doi: 10.1016/j.taap.2006.04.015. Epub 2006 May 19.
• [678] Quantitative analysis of gene expression changes in response to genotoxic compounds. Toxicol In Vitro. 2017 Mar;39:15-28. doi: 10.1016/j.tiv.2016.11.004. Epub 2016 Nov 5.
• [679] Induction of apoptosis by cidofovir in human papillomavirus (HPV)-positive cells. Oncol Res. 2000;12(9-10):397-408. doi: 10.3727/096504001108747855.
• [680] Gallic acid potentiates the apoptotic effect of paclitaxel and carboplatin via overexpression of Bax and P53 on the MCF-7 human breast cancer cell line. J Biochem Mol Toxicol. 2021 Feb;35(2):e22638. doi: 10.1002/jbt.22638. Epub 2020 Oct 1.
• [681] Regulation of human dUTPase gene expression and p53-mediated transcriptional repression in response to oxaliplatin-induced DNA damage. Nucleic Acids Res. 2009 Jan;37(1):78-95. doi: 10.1093/nar/gkn910. Epub 2008 Nov 16.
• [682] Nitrogen Mustard Alkylates and Cross-Links p53 in Human Keratinocytes. Chem Res Toxicol. 2022 Apr 18;35(4):636-650. doi: 10.1021/acs.chemrestox.1c00420. Epub 2022 Mar 21.
• [683] Fulvestrant induces resistance by modulating GPER and CDK6 expression: implication of methyltransferases, deacetylases and the hSWI/SNF chromatin remodelling complex. Br J Cancer. 2013 Nov 12;109(10):2751-62. doi: 10.1038/bjc.2013.583. Epub 2013 Oct 29.
• [684] Indomethacin inhibits cell growth of medullary thyroid carcinoma by reducing cell cycle progression into S phase. Exp Biol Med (Maywood). 2008 Nov;233(11):1433-40. doi: 10.3181/0804-RM-127. Epub 2008 Sep 12.
• [685] Therapeutically activating RB: reestablishing cell cycle control in endocrine therapy-resistant breast cancer. Endocr Relat Cancer. 2011 Apr 28;18(3):333-45. doi: 10.1530/ERC-10-0262. Print 2011 Jun.
• [686] HMG-CoA reductase inhibitor simvastatin inhibits cell cycle progression at the G1/S checkpoint in immortalized lymphocytes from Alzheimer's disease patients independently of cholesterol-lowering effects. J Pharmacol Exp Ther. 2008 Jan;324(1):352-9. doi: 10.1124/jpet.107.128959. Epub 2007 Oct 10.
• [687] Oxidative modifications of proteins by sodium arsenite in human umbilical vein endothelial cells. Environ Toxicol. 2011 Oct;26(5):459-71. doi: 10.1002/tox.20572. Epub 2010 Mar 1.
• [688] Proteomic identification of differentially expressed proteins associated with the multiple drug resistance in methotrexate-resistant human breast cancer cells. Int J Oncol. 2014 Jul;45(1):448-58.
• [689] Differential protein expression of peroxiredoxin I and II by benzo(a)pyrene and quercetin treatment in 22Rv1 and PrEC prostate cell lines. Toxicol Appl Pharmacol. 2007 Apr 15;220(2):197-210. doi: 10.1016/j.taap.2006.12.030. Epub 2007 Jan 9.
• [690] Thyroid hormone responsive genes in cultured human fibroblasts. J Clin Endocrinol Metab. 2005 Feb;90(2):936-43.
• [691] Resveratrol modulates the phosphoinositide 3-kinase pathway through an estrogen receptor alpha-dependent mechanism: relevance in cell proliferation. Int J Cancer. 2004 Mar 20;109(2):167-73. doi: 10.1002/ijc.11720.
• [692] Glucosamine sulfate-induced apoptosis in chronic myelogenous leukemia K562 cells is associated with translocation of cathepsin D and downregulation of Bcl-xL. Apoptosis. 2006 Oct;11(10):1851-60. doi: 10.1007/s10495-006-9529-6.
• [693] Src Family Kinase Inhibitor PP2 Has Different Effects on All-Trans-Retinoic Acid or Arsenic Trioxide-Induced Differentiation of an Acute Promyelocytic Leukemia Cell Line. Cancer Res Treat. 2013 Jun;45(2):126-33. doi: 10.4143/crt.2013.45.2.126. Epub 2013 Jun 30.
• [694] Reactive metabolite of gefitinib activates inflammasomes: implications for gefitinib-induced idiosyncratic reaction. J Toxicol Sci. 2020;45(11):673-680. doi: 10.2131/jts.45.673.
• [695] Simvastatin induces heat shock factor 1 in vascular endothelial cells. Atherosclerosis. 2006 Oct;188(2):265-73. doi: 10.1016/j.atherosclerosis.2005.10.045. Epub 2005 Dec 20.
• [696] Gene expression changes in human small airway epithelial cells exposed to Delta9-tetrahydrocannabinol. Toxicol Lett. 2005 Aug 14;158(2):95-107.
• [697] Impaired migration of trophoblast cells caused by simvastatin is associated with decreased membrane IGF-I receptor, MMP2 activity and HSP27 expression. Hum Reprod. 2007 Apr;22(4):1161-7. doi: 10.1093/humrep/del464. Epub 2006 Dec 11.
• [698] Quercetin Suppresses the Migration and Invasion in Human Colon Cancer Caco-2 Cells Through Regulating Toll-like Receptor 4/Nuclear Factor-kappa B Pathway. Pharmacogn Mag. 2016 May;12(Suppl 2):S237-44. doi: 10.4103/0973-1296.182154. Epub 2016 May 11.
• [699] Troglitazone but not conjugated linoleic acid reduces gene expression and activity of matrix-metalloproteinases-2 and -9 in PMA-differentiated THP-1 macrophages. J Nutr Biochem. 2008 Sep;19(9):594-603. doi: 10.1016/j.jnutbio.2007.08.003. Epub 2007 Dec 21.
• [700] Repetitive nonlethal oxidant injury to retinal pigment epithelium decreased extracellular matrix turnover in vitro and induced sub-RPE deposits in vivo. Invest Ophthalmol Vis Sci. 2006 Sep;47(9):4098-112. doi: 10.1167/iovs.05-1230.
• [701] Inhibiting Heat Shock Proteins Can Potentiate the Cytotoxic Effect of Cannabidiol in Human Glioma Cells. Anticancer Res. 2015 Nov;35(11):5827-37.
• [702] ERE-independent ERalpha target genes differentially expressed in human breast tumors. Mol Cell Endocrinol. 2005 Dec 21;245(1-2):53-9. doi: 10.1016/j.mce.2005.10.003. Epub 2005 Nov 17.
• [703] High selenium status in individuals exposed to arsenic through coal-burning in Shaanxi (PR of China) modulates antioxidant enzymes, heme oxygenase-1 and DNA damage. Clin Chim Acta. 2010 Sep 6;411(17-18):1312-8.
• [704] Dimethyl Fumarate Inhibits the Nuclear Factor B Pathway in Breast Cancer Cells by Covalent Modification of p65 Protein. J Biol Chem. 2016 Feb 12;291(7):3639-47. doi: 10.1074/jbc.M115.679704. Epub 2015 Dec 18.
• [705] Combination treatment with arsenic trioxide and sulindac enhances apoptotic cell death in lung cancer cells via activation of oxidative stress and mitogen-activated protein kinases. Oncol Rep. 2008 Aug;20(2):379-84.
• [706] Evidence of securin-mediated resistance to gefitinib-induced apoptosis in human cancer cells. Chem Biol Interact. 2013 Apr 25;203(2):412-22. doi: 10.1016/j.cbi.2013.03.011. Epub 2013 Mar 22.
• [707] Cigarette smoke and asbestos activate poly-ADP-ribose polymerase in alveolar epithelial cells. J Investig Med. 2001 Jan;49(1):68-76. doi: 10.2310/6650.2001.34092.
• [708] The antidepressants imipramine, clomipramine, and citalopram induce apoptosis in human acute myeloid leukemia HL-60 cells via caspase-3 activation. J Biochem Mol Toxicol. 1999;13(6):338-47. doi: 10.1002/(sici)1099-0461(1999)13:6<338::aid-jbt8>3.0.co;2-7.
• [709] Investigation of molecular mechanisms underlying the antiproliferative effects of colchicine against PC3 prostate cancer cells. Toxicol In Vitro. 2021 Jun;73:105138. doi: 10.1016/j.tiv.2021.105138. Epub 2021 Mar 6.
• [710] Sulindac enhances adenoviral vector expressing mda-7/IL-24-mediated apoptosis in human lung cancer. Mol Cancer Ther. 2005 Feb;4(2):291-304.
• [711] Methotrexate induces poly(ADP-ribose) polymerase-dependent, caspase 3-independent apoptosis in subsets of proliferating CD4+ T cells. Clin Exp Immunol. 2007 May;148(2):288-95. doi: 10.1111/j.1365-2249.2007.03335.x. Epub 2007 Feb 7.
• [712] Serious carbamazepine-induced hypersensitivity reactions associated with the HSP70 gene cluster. Pharmacogenet Genomics. 2006 Apr;16(4):287-96. doi: 10.1097/01.fpc.0000189800.88596.7a.
• [713] Identification of biomarkers for the initiation of apoptosis in human preneoplastic colonocytes by proteome analysis. Int J Cancer. 2004 Mar 20;109(2):220-9. doi: 10.1002/ijc.11692.
• [714] Lon protease and eiF2 are involved in acute, but not prolonged, antiretroviral induced stress response in HepG2 cells. Chem Biol Interact. 2016 May 25;252:82-6. doi: 10.1016/j.cbi.2016.03.021. Epub 2016 Apr 1.
• [715] Darinaparsin induces a unique cellular response and is active in an arsenic trioxide-resistant myeloma cell line. Mol Cancer Ther. 2009 May;8(5):1197-206.
• [716] Drug-induced hepatic steatosis in absence of severe mitochondrial dysfunction in HepaRG cells: proof of multiple mechanism-based toxicity. Cell Biol Toxicol. 2021 Apr;37(2):151-175. doi: 10.1007/s10565-020-09537-1. Epub 2020 Jun 14.
• [717] K-RAS transformation in prostate epithelial cell overcomes H2O2-induced apoptosis via upregulation of gamma-glutamyltransferase-2. Toxicol In Vitro. 2012 Apr;26(3):429-34. doi: 10.1016/j.tiv.2012.01.013. Epub 2012 Jan 17.
• [718] High-content imaging-based BAC-GFP toxicity pathway reporters to assess chemical adversity liabilities. Arch Toxicol. 2017 Mar;91(3):1367-1383. doi: 10.1007/s00204-016-1781-0. Epub 2016 Jun 29.
• [719] Enhanced GRP78 protein expression via the IRE1/ASK1/p38 MAPK pathway during As(2)O(3)-induced endoplasmic reticulum stress in BEAS-2B cells. Toxicology. 2021 Oct;462:152962. doi: 10.1016/j.tox.2021.152962. Epub 2021 Sep 21.
• [720] [Simvastatin-induced apoptosis of K562 cells is mediated by endoplasmic reticulum stress]. Yao Xue Xue Bao. 2008 Apr;43(4):371-7.
• [721] Chronic oxycodone induces integrated stress response in rat brain. BMC Neurosci. 2015 Sep 16;16:58. doi: 10.1186/s12868-015-0197-8.
• [722] Involvement of the activation of Nrf2/HO-1, p38 MAPK signaling pathways and endoplasmic reticulum stress in furazolidone induced cytotoxicity and S phase arrest in human hepatocyte L02 cells: modulation of curcumin. Toxicol Mech Methods. 2017 Mar;27(3):165-172. doi: 10.1080/15376516.2016.1273424. Epub 2017 Jan 8.
• [723] Imatinib disturbs lysosomal function and morphology and impairs the activity of mTORC1 in human hepatocyte cell lines. Food Chem Toxicol. 2022 Apr;162:112869. doi: 10.1016/j.fct.2022.112869. Epub 2022 Feb 16.
• [724] Induction of Sestrin2 by pterostilbene suppresses ethanol-triggered hepatocyte senescence by degrading CCN1 via p62-dependent selective autophagy. Cell Biol Toxicol. 2023 Jun;39(3):729-749. doi: 10.1007/s10565-021-09635-8. Epub 2021 Aug 17.
• [725] Rosiglitazone induces autophagy in H295R and cell cycle deregulation in SW13 adrenocortical cancer cells. Exp Cell Res. 2011 Jun 10;317(10):1397-410. doi: 10.1016/j.yexcr.2011.02.014. Epub 2011 Mar 3.
• [726] MS4A3-HSP27 target pathway reveals potential for haematopoietic disorder treatment in alimentary toxic aleukia. Cell Biol Toxicol. 2023 Feb;39(1):201-216. doi: 10.1007/s10565-021-09639-4. Epub 2021 Sep 28.
• [727] Epinephrine facilitates the growth of T cell lymphoma by altering cell proliferation, apoptosis, and glucose metabolism. Chem Biol Interact. 2023 Jan 5;369:110278. doi: 10.1016/j.cbi.2022.110278. Epub 2022 Nov 22.
• [728] Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21.
• [729] Cannabinoids synergize with carfilzomib, reducing multiple myeloma cells viability and migration. Oncotarget. 2016 Nov 22;7(47):77543-77557. doi: 10.18632/oncotarget.12721.
• [730] Hsa-let-7g miRNA regulates the anti-tumor effects of gastric cancer cells under oxidative stress through the expression of DDR genes. J Toxicol Sci. 2015 Jun;40(3):329-38. doi: 10.2131/jts.40.329.
• [731] Inhibition of cardiomyocyte differentiation of human induced pluripotent stem cells by Ribavirin: Implication for its cardiac developmental toxicity. Toxicology. 2020 Apr 15;435:152422. doi: 10.1016/j.tox.2020.152422. Epub 2020 Feb 26.
• [732] Synthesis and structure-activity relationships of new antiproliferative and proapoptotic retinoid-related biphenyl-4-yl-acrylic acids. Bioorg Med Chem. 2007 Jul 15;15(14):4863-75. doi: 10.1016/j.bmc.2007.04.057. Epub 2007 May 3.
• [733] Methotrexate induces apoptosis through p53/p21-dependent pathway and increases E-cadherin expression through downregulation of HDAC/EZH2. Biochem Pharmacol. 2011 Feb 15;81(4):510-7. doi: 10.1016/j.bcp.2010.11.014. Epub 2010 Nov 27.
• [734] Actinomycin D inhibits the expression of the cystine/glutamate transporter xCT via attenuation of CD133 synthesis in CD133(+) HCC. Chem Biol Interact. 2019 Aug 25;309:108713. doi: 10.1016/j.cbi.2019.06.026. Epub 2019 Jun 19.
• [735] Simvastatin and purine analogs have a synergic effect on apoptosis of chronic lymphocytic leukemia cells. Ann Hematol. 2010 Nov;89(11):1115-24. doi: 10.1007/s00277-010-0988-z. Epub 2010 May 25.
• [736] The isoflavonoids genistein and quercetin activate different stress signaling pathways as shown by analysis of site-specific phosphorylation of ATM, p53 and histone H2AX. DNA Repair (Amst). 2004 Mar 4;3(3):235-44. doi: 10.1016/j.dnarep.2003.10.014.
• [737] Development and validation of the TGx-HDACi transcriptomic biomarker to detect histone deacetylase inhibitors in human TK6 cells. Arch Toxicol. 2021 May;95(5):1631-1645. doi: 10.1007/s00204-021-03014-2. Epub 2021 Mar 26.
• [738] Identification of novel activators of the metal responsive transcription factor (MTF-1) using a gene expression biomarker in a microarray compendium. Metallomics. 2020 Sep 23;12(9):1400-1415. doi: 10.1039/d0mt00071j.
• [739] Tea polyphenols direct Bmal1-driven ameliorating of the redox imbalance and mitochondrial dysfunction in hepatocytes. Food Chem Toxicol. 2018 Dec;122:181-193.
• [740] Biotinylated quercetin as an intrinsic photoaffinity proteomics probe for the identification of quercetin target proteins. Bioorg Med Chem. 2011 Aug 15;19(16):4710-20. doi: 10.1016/j.bmc.2011.07.005. Epub 2011 Jul 13.
• [741] Detection of gene expression alteration of myeloma cells treated with arsenic trioxide. Zhonghua Xue Ye Xue Za Zhi. 2005 Apr;26(4):209-13.
• [742] 9-Tetrahydrocannabinol leads to endoplasmic reticulum stress and mitochondrial dysfunction in human BeWo trophoblasts. Reprod Toxicol. 2019 Aug;87:21-31. doi: 10.1016/j.reprotox.2019.04.008. Epub 2019 May 1.
• [743] Proteomics analysis of the proliferative effect of low-dose ouabain on human endothelial cells. Biol Pharm Bull. 2007 Feb;30(2):247-53. doi: 10.1248/bpb.30.247.
• [744] Growth inhibition of ovarian tumor-initiating cells by niclosamide. Mol Cancer Ther. 2012 Aug;11(8):1703-12.
• [745] PGK1 induction by a hydrogen peroxide treatment is suppressed by antioxidants in human colon carcinoma cells. Biosci Biotechnol Biochem. 2008 Jul;72(7):1799-808. doi: 10.1271/bbb.80079. Epub 2008 Jul 7.
• [746] Peroxisome proliferator-activated receptor ligands affect growth-related gene expression in human leukemic cells. J Pharmacol Exp Ther. 2003 Jun;305(3):932-42. doi: 10.1124/jpet.103.049098. Epub 2003 Mar 20.
• [747] Retinoid targeting of different D-type cyclins through distinct chemopreventive mechanisms. Cancer Res. 2005 Jul 15;65(14):6476-83. doi: 10.1158/0008-5472.CAN-05-0370.
• [748] Zidovudine induces S-phase arrest and cell cycle gene expression changes in human cells. Mutagenesis. 2005 Mar;20(2):139-46. doi: 10.1093/mutage/gei019. Epub 2005 Mar 22.
• [749] Inhibition of cholesterol metabolism underlies synergy between mTOR pathway inhibition and chloroquine in bladder cancer cells. Oncogene. 2016 Aug 25;35(34):4518-28. doi: 10.1038/onc.2015.511. Epub 2016 Feb 8.
• [750] Nicotine-induced survival signaling in lung cancer cells is dependent on their p53 status while its down-regulation by curcumin is independent. Mol Cancer. 2010 Aug 20;9:220.
• [751] -Carotene Induces Apoptosis in Human Esophageal Squamous Cell Carcinoma Cell Lines via the Cav-1/AKT/NF-B Signaling Pathway. J Biochem Mol Toxicol. 2016 Mar;30(3):148-57. doi: 10.1002/jbt.21773. Epub 2016 Jan 6.
• [752] Dihydromyricetin suppresses tumor growth via downregulation of the EGFR/Akt/survivin signaling pathway. J Biochem Mol Toxicol. 2023 Jun;37(6):e23328. doi: 10.1002/jbt.23328. Epub 2023 Feb 19.
• [753] Oxidative stress induces parallel autophagy and mitochondria dysfunction in human glioma U251 cells. Toxicol Sci. 2009 Aug;110(2):376-88. doi: 10.1093/toxsci/kfp101. Epub 2009 May 18.
• [754] Effect of toll-like receptor 7 and 9 targeted therapy to prevent the development of hepatocellular carcinoma. Liver Int. 2015 Mar;35(3):1063-76. doi: 10.1111/liv.12626. Epub 2014 Jul 30.
• [755] Characterization of multidrug transporter-mediated efflux of avermectins in human and mouse neuroblastoma cell lines. Toxicol Lett. 2015 Jun 15;235(3):189-98. doi: 10.1016/j.toxlet.2015.04.005. Epub 2015 Apr 9.
• [756] Folate concentration dependent transport activity of the Multidrug Resistance Protein 1 (ABCC1). Biochem Pharmacol. 2004 Apr 15;67(8):1541-8.
• [757] Methotrexate normalizes up-regulated folate pathway genes in rheumatoid arthritis. Arthritis Rheum. 2013 Nov;65(11):2791-802.
• [758] Influence of redox-active compounds and PXR-activators on human MRP1 and MRP2 gene expression. Toxicology. 2002 Feb 28;171(2-3):137-46.
• [759] Enhanced in vitro invasiveness and drug resistance with altered gene expression patterns in a human lung carcinoma cell line after pulse selection with anticancer drugs. Int J Cancer. 2004 Sep 10;111(4):484-93. doi: 10.1002/ijc.20230.
• [760] Co-encapsulation of chrysophsin-1 and epirubicin in PEGylated liposomes circumvents multidrug resistance in HeLa cells. Chem Biol Interact. 2015 Dec 5;242:13-23. doi: 10.1016/j.cbi.2015.08.023. Epub 2015 Sep 1.
• [761] Upregulation of multi drug resistance genes in doxorubicin resistant human acute myelogeneous leukemia cells and reversal of the resistance. Hematology. 2007 Dec;12(6):511-7. doi: 10.1080/10245330701562535.
• [762] Functional analysis of MRP1 cloned from bovine. FEBS Lett. 2002 Jun 19;521(1-3):211-3. doi: 10.1016/s0014-5793(02)02816-8.
• [763] Isoproterenol effects evaluated in heart slices of human and rat in comparison to rat heart in vivo. Toxicol Appl Pharmacol. 2014 Jan 15;274(2):302-12.
• [764] Mitochondrial dysfunction induced by leflunomide and its active metabolite. Toxicology. 2018 Mar 1;396-397:33-45.
• [765] COX-2 and PPAR-gama confer cannabidiol-induced apoptosis of human lung cancer cells. Mol Cancer Ther. 2013 Jan;12(1):69-82.
• [766] The effect of quercetin and kaempferol aglycones and glucuronides on peroxisome proliferator-activated receptor-gamma (PPAR-). Food Funct. 2015 Apr;6(4):1098-107. doi: 10.1039/c5fo00076a.
• [767] Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-gamma ligand troglitazone in patients with liposarcoma. Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3951-6. doi: 10.1073/pnas.96.7.3951.
• [768] Glucosamine sulfate reduces prostaglandin E(2) production in osteoarthritic chondrocytes through inhibition of microsomal PGE synthase-1. J Rheumatol. 2012 Mar;39(3):635-44. doi: 10.3899/jrheum.110621. Epub 2011 Nov 15.
• [769] Isoniazid suppresses antioxidant response element activities and impairs adipogenesis in mouse and human preadipocytes. Toxicol Appl Pharmacol. 2013 Dec 15;273(3):435-41. doi: 10.1016/j.taap.2013.10.005. Epub 2013 Oct 12.
• [770] Regulatory role of KEAP1 and NRF2 in PPAR expression and chemoresistance in human non-small-cell lung carcinoma cells. Free Radic Biol Med. 2012 Aug 15;53(4):758-68. doi: 10.1016/j.freeradbiomed.2012.05.041. Epub 2012 Jun 7.
• [771] Aspirin inhibits MMP-9 mRNA expression and release via the PPARalpha/gamma and COX-2/mPGES-1-mediated pathways in macrophages derived from THP-1 cells. Biomed Pharmacother. 2010 Feb;64(2):118-23. doi: 10.1016/j.biopha.2009.04.033. Epub 2009 Oct 17.
• [772] Mitochondrial proliferation, DNA depletion and adipocyte differentiation in subcutaneous adipose tissue of HIV-positive HAART recipients. Antivir Ther. 2003 Aug;8(4):323-31.
• [773] Antihypertrophic Effects of Small Molecules that Maintain Mitochondrial ATP Levels Under Hypoxia. EBioMedicine. 2017 Oct;24:147-158. doi: 10.1016/j.ebiom.2017.09.022. Epub 2017 Sep 19.
• [774] Role of oxidative stress in the induction of metallothionein-2A and heme oxygenase-1 gene expression by the antineoplastic agent gallium nitrate in human lymphoma cells. Free Radic Biol Med. 2008 Sep 15;45(6):763-72.
• [775] Mitochondrial proteomics investigation of a cellular model of impaired dopamine homeostasis, an early step in Parkinson's disease pathogenesis. Mol Biosyst. 2014 Jun;10(6):1332-44.
• [776] Leptomycin B reduces primary and acquired resistance of gefitinib in lung cancer cells. Toxicol Appl Pharmacol. 2017 Nov 15;335:16-27. doi: 10.1016/j.taap.2017.09.017. Epub 2017 Sep 21.
• [777] Glucocorticoids induce G1 arrest of lymphoblastic cells through retinoblastoma protein Rb1 dephosphorylation in childhood acute lymphoblastic leukemia in vivo. Cancer Biol Ther. 2004 May;3(5):470-6. doi: 10.4161/cbt.3.5.838. Epub 2004 May 9.
• [778] Different apoptosis ratios and gene expressions in two human cell lines after sevoflurane anaesthesia. Acta Anaesthesiol Scand. 2009 Oct;53(9):1192-9. doi: 10.1111/j.1399-6576.2009.02036.x. Epub 2009 Jun 30.
• [779] [Mechanisms underlying the effect of arsenic trioxide on proliferation inhibition and apoptosis induction in myeloma cell line u266]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2007 Oct;15(5):982-5.
• [780] Lovastatin lactone elicits human lung cancer cell apoptosis via a COX-2/PPAR-dependent pathway. Oncotarget. 2016 Mar 1;7(9):10345-62. doi: 10.18632/oncotarget.7213.
• [781] Comparison of burst of reactive oxygen species and activation of caspase-3 in apoptosis of K562 and HL-60 cells induced by docetaxel. Cancer Lett. 2004 Oct 8;214(1):103-13. doi: 10.1016/j.canlet.2004.03.047.
• [782] Induction of mitochondrial manganese superoxide dismutase confers resistance to apoptosis in acute myeloblastic leukaemia cells exposed to etoposide. Br J Haematol. 2000 Mar;108(3):574-81. doi: 10.1046/j.1365-2141.2000.01852.x.
• [783] Cisplatin-enhanced sensitivity of glioblastoma multiforme U251 cells to adenovirus-delivered TRAIL in vitro. Tumour Biol. 2010 Dec;31(6):613-22. doi: 10.1007/s13277-010-0077-x. Epub 2010 Jul 11.
• [784] Insulin-like growth factor I is the key growth factor in serum that protects neuroblastoma cells from hyperosmotic-induced apoptosis. J Cell Physiol. 2000 Jan;182(1):24-32. doi: 10.1002/(SICI)1097-4652(200001)182:1<24::AID-JCP3>3.0.CO;2-6.
• [785] mRNA expression analysis of a variety of apoptosis-related genes, including the novel gene of the BCL2-family, BCL2L12, in HL-60 leukemia cells after treatment with carboplatin and doxorubicin. Biol Chem. 2004 Nov;385(11):1099-103. doi: 10.1515/BC.2004.143.
• [786] Cisplatin induces autophagy to enhance hepatitis B virus replication via activation of ROS/JNK and inhibition of the Akt/mTOR pathway. Free Radic Biol Med. 2019 Feb 1;131:225-236. doi: 10.1016/j.freeradbiomed.2018.12.008. Epub 2018 Dec 11.
• [787] Frankincense myrrh attenuates hepatocellular carcinoma by regulating tumor blood vessel development through multiple epidermal growth factor receptor-mediated signaling pathways. World J Gastrointest Oncol. 2022 Feb 15;14(2):450-477. doi: 10.4251/wjgo.v14.i2.450.
• [788] Disease-modifying effects of glucosamine HCl involving regulation of metalloproteinases and chemokines activated by interleukin-1beta in human primary synovial fibroblasts. J Cell Biochem. 2008 May 1;104(1):38-50. doi: 10.1002/jcb.21597.
• [789] Characterization of cell death induced by ethacrynic acid in a human colon cancer cell line DLD-1 and suppression by N-acetyl-L-cysteine. Cancer Sci. 2003 Oct;94(10):886-93.
• [790] Methotrexate increases expression of cell cycle checkpoint genes via JNK activation. Arthritis Rheum. 2012 Jun;64(6):1780-9. doi: 10.1002/art.34342. Epub 2011 Dec 19.
• [791] Synergistic promotion of breast cancer cells death by targeting molecular chaperone GRP78 and heat shock protein 70. J Cell Mol Med. 2009 Nov-Dec;13(11-12):4540-50. doi: 10.1111/j.1582-4934.2008.00575.x.
• [792] Arsenic trioxide induces apoptosis in chronic myelogenous leukemia K562 cells: possible involvement of p38 MAP kinase. J Biochem Mol Biol. 2002 Jul 31;35(4):377-83. doi: 10.5483/bmbrep.2002.35.4.377.
• [793] Intracellular mobility and nuclear trafficking of the stress-activated kinase JNK1 are impeded by hyperosmotic stress. Biochim Biophys Acta. 2014 Feb;1843(2):253-64. doi: 10.1016/j.bbamcr.2013.10.017. Epub 2013 Nov 1.
• [794] Lovastatin induces apoptosis of anaplastic thyroid cancer cells via inhibition of protein geranylgeranylation and de novo protein synthesis. Endocrinology. 2003 Sep;144(9):3852-9. doi: 10.1210/en.2003-0098.
• [795] Insulin-like growth factor I prevents mannitol-induced degradation of focal adhesion kinase and Akt. J Biol Chem. 2002 Jul 26;277(30):27393-400. doi: 10.1074/jbc.M201963200. Epub 2002 May 14.
• [796] Inhibition of caspase-dependent mitochondrial permeability transition protects airway epithelial cells against mustard-induced apoptosis. Apoptosis. 2006 Sep;11(9):1545-59. doi: 10.1007/s10495-006-8764-1.
• [797] The effects of quercetin in cultured human RPE cells under oxidative stress and in Ccl2/Cx3cr1 double deficient mice. Exp Eye Res. 2010 Jul;91(1):15-25.
• [798] Inhibiting AKT signaling pathway with cilostazol and meloxicam synergism for suppressing K562 cells in vitro. J Biochem Mol Toxicol. 2022 Nov;36(11):e23185. doi: 10.1002/jbt.23185. Epub 2022 Aug 3.
• [799] Colchicine-induced apoptosis in human normal liver L-02 cells by mitochondrial mediated pathways. Toxicol In Vitro. 2012 Aug;26(5):649-55. doi: 10.1016/j.tiv.2012.01.024. Epub 2012 Feb 8.
• [800] Protein profile in neuroblastoma cells incubated with S- and R-enantiomers of ibuprofen by iTRAQ-coupled 2-D LC-MS/MS analysis: possible action of induced proteins on Alzheimer's disease. Proteomics. 2008 Apr;8(8):1595-607. doi: 10.1002/pmic.200700556.
• [801] The neuroprotective effect of ladostigil against hydrogen peroxide-mediated cytotoxicity. Chem Biol Interact. 2008 Sep 25;175(1-3):318-26. doi: 10.1016/j.cbi.2008.05.038. Epub 2008 Jun 12.
• [802] Autophagy Inhibition Overcomes the Antagonistic Effect Between Gefitinib and Cisplatin in Epidermal Growth Factor Receptor Mutant Non--Small-Cell Lung Cancer Cells. Clin Lung Cancer. 2015 Sep;16(5):e55-66. doi: 10.1016/j.cllc.2015.03.006. Epub 2015 Apr 2.
• [803] Harnessing autophagy to overcome mitogen-activated protein kinase kinase inhibitor-induced resistance in metastatic melanoma. Br J Dermatol. 2019 Feb;180(2):346-356. doi: 10.1111/bjd.17333. Epub 2018 Nov 25.
• [804] All-trans-retinoic acid inhibits collapsin response mediator protein-2 transcriptional activity during SH-SY5Y neuroblastoma cell differentiation. FEBS J. 2007 Jan;274(2):498-511. doi: 10.1111/j.1742-4658.2006.05597.x.
• [805] Cigarette smoke affects keratinocytes SRB1 expression and localization via H2O2 production and HNE protein adducts formation. PLoS One. 2012;7(3):e33592. doi: 10.1371/journal.pone.0033592. Epub 2012 Mar 19.
• [806] Induction of scavenger receptor class B type I is critical for simvastatin enhancement of high-density lipoprotein-induced anti-inflammatory actions in endothelial cells. J Immunol. 2008 Nov 15;181(10):7332-40. doi: 10.4049/jimmunol.181.10.7332.
• [807] Farnesoid X receptor induces murine scavenger receptor Class B type I via intron binding. PLoS One. 2012;7(4):e35895. doi: 10.1371/journal.pone.0035895. Epub 2012 Apr 23.
• [808] Pregnane X receptor-agonists down-regulate hepatic ATP-binding cassette transporter A1 and scavenger receptor class B type I. Biochem Biophys Res Commun. 2005 Jun 17;331(4):1533-41. doi: 10.1016/j.bbrc.2005.04.071.
• [809] Stimulation of CD36 and the key effector of reverse cholesterol transport ATP-binding cassette A1 in monocytoid cells by niacin. Biochem Pharmacol. 2004 Feb 1;67(3):411-9. doi: 10.1016/j.bcp.2003.09.014.
• [810] Carotenoid transport is decreased and expression of the lipid transporters SR-BI, NPC1L1, and ABCA1 is downregulated in Caco-2 cells treated with ezetimibe. J Nutr. 2005 Oct;135(10):2305-12. doi: 10.1093/jn/135.10.2305.
• [811] Screening autism-associated environmental factors in differentiating human neural progenitors with fractional factorial design-based transcriptomics. Sci Rep. 2023 Jun 29;13(1):10519. doi: 10.1038/s41598-023-37488-0.
• [812] Gene expression profiling of breast cancer cells in response to gemcitabine: NF-kappaB pathway activation as a potential mechanism of resistance. Breast Cancer Res Treat. 2007 Apr;102(2):157-72.
• [813] Amiodarone sensitizes human glioma cells but not astrocytes to TRAIL-induced apoptosis via CHOP-mediated DR5 upregulation. Neuro Oncol. 2011 Mar;13(3):267-79. doi: 10.1093/neuonc/noq195. Epub 2011 Feb 3.
• [814] Endoplasmic Reticulum Stress Induction and ERK1/2 Activation Contribute to Nefazodone-Induced Toxicity in Hepatic Cells. Toxicol Sci. 2016 Dec;154(2):368-380. doi: 10.1093/toxsci/kfw173. Epub 2016 Sep 9.
• [815] [Mechanism of arsenic trioxide induced apoptosis in cultured human lens epithelium cells]. Zhonghua Yan Ke Za Zhi. 2008 Oct;44(10):916-20.
• [816] Inhibition of fatty acid synthase induces endoplasmic reticulum stress in tumor cells. Cancer Res. 2007 Feb 1;67(3):1262-9. doi: 10.1158/0008-5472.CAN-06-1794.
• [817] Low Autophagy (ATG) Gene Expression Is Associated with an Immature AML Blast Cell Phenotype and Can Be Restored during AML Differentiation Therapy. Oxid Med Cell Longev. 2018 Mar 18;2018:1482795. doi: 10.1155/2018/1482795. eCollection 2018.
• [818] TNF enhances trovafloxacin-induced in vitro hepatotoxicity by inhibiting protective autophagy. Toxicol Lett. 2021 May 15;342:73-84. doi: 10.1016/j.toxlet.2021.02.009. Epub 2021 Feb 17.
• [819] Inhibition of autophagy enhances Hydroquinone-induced TK6 cell death. Toxicol In Vitro. 2017 Jun;41:123-132. doi: 10.1016/j.tiv.2017.02.024. Epub 2017 Mar 2.
• [820] Vitamin D3 induces autophagy in human monocytes/macrophages via cathelicidin. Cell Host Microbe. 2009 Sep 17;6(3):231-43. doi: 10.1016/j.chom.2009.08.004.
• [821] Flavones and flavonols exert cytotoxic effects on a human oesophageal adenocarcinoma cell line (OE33) by causing G2/M arrest and inducing apoptosis. Food Chem Toxicol. 2008 Jun;46(6):2042-53. doi: 10.1016/j.fct.2008.01.049. Epub 2008 Feb 7.
• [822] Induction of TAp63 by histone deacetylase inhibitors. Biochem Biophys Res Commun. 2010 Jan 22;391(4):1748-51. doi: 10.1016/j.bbrc.2009.12.147. Epub 2009 Dec 30.
• [823] Bone marrow osteoblast damage by chemotherapeutic agents. PLoS One. 2012;7(2):e30758. doi: 10.1371/journal.pone.0030758. Epub 2012 Feb 17.
• [824] p63 involvement in poly(ADP-ribose) polymerase 1 signaling of topoisomerase I-dependent DNA damage in carcinoma cells. Biochem Pharmacol. 2013 Apr 1;85(7):999-1006. doi: 10.1016/j.bcp.2013.01.019. Epub 2013 Jan 29.
• [825] Effect of cyclophosphamide on gene expression of cytochromes p450 and beta-actin in the HL-60 cell line. Eur J Pharmacol. 2002 Aug 9;449(3):197-205.
• [826] Toxicogenomics of kojic acid on gene expression profiling of a375 human malignant melanoma cells. Biol Pharm Bull. 2006 Apr;29(4):655-69.
• [827] Expression Profiling of Human Pluripotent Stem Cell-Derived Cardiomyocytes Exposed to Doxorubicin-Integration and Visualization of Multi-Omics Data. Toxicol Sci. 2018 May 1;163(1):182-195. doi: 10.1093/toxsci/kfy012.
• [828] Transcriptomic analysis of human primary bronchial epithelial cells after chloropicrin treatment. Chem Res Toxicol. 2015 Oct 19;28(10):1926-35.
• [829] Inhibition of glutathione S-transferases by antimalarial drugs possible implications for circumventing anticancer drug resistance. Int J Cancer. 2002 Feb 10;97(5):700-5.
• [830] Human glutathione S-transferase A (GSTA) family genes are regulated by steroidogenic factor 1 (SF-1) and are involved in steroidogenesis. FASEB J. 2013 Aug;27(8):3198-208. doi: 10.1096/fj.12-222745. Epub 2013 May 6.
• [831] Polymorphisms of drug-metabolizing enzymes (GST, CYP2B6 and CYP3A) affect the pharmacokinetics of thiotepa and tepa. Br J Clin Pharmacol. 2009 Jan;67(1):50-60. doi: 10.1111/j.1365-2125.2008.03321.x. Epub 2008 Nov 17.
• [832] Effects of phenytoin on glutathione status and oxidative stress biomarker gene mRNA levels in cultured precision human liver slices. Toxicol Sci. 2001 Jan;59(1):118-26.
• [833] Acetaminophen-induced hepatocyte injury: C2-ceramide and oltipraz intervention, hepatocyte nuclear factor 1 and glutathione S-transferase A1 changes. J Appl Toxicol. 2019 Dec;39(12):1640-1650. doi: 10.1002/jat.3881. Epub 2019 Aug 6.
• [834] Antineoplastic drug sensitivity of human MCF-7 breast cancer cells stably transfected with a human alpha class glutathione S-transferase gene. Cancer Res. 1991 Jan 15;51(2):587-94.
• [835] Establishment of cisplatin-resistant ovarian yolk sac tumor cells and investigation of the mechanism of cisplatin resistance using this cell line. Gynecol Obstet Invest. 2011;71(2):104-11. doi: 10.1159/000320744. Epub 2010 Dec 9.
• [836] Overexpression of glutathione S-transferase A1-1 in ECV 304 cells protects against busulfan mediated G2-arrest and induces tissue factor expression. Br J Pharmacol. 2002 Dec;137(7):1100-6. doi: 10.1038/sj.bjp.0704972.
• [837] TGF-1 signaling protects retinal ganglion cells from oxidative stress via modulation of the HO-1/Nrf2 pathway. Chem Biol Interact. 2020 Nov 1;331:109249. doi: 10.1016/j.cbi.2020.109249. Epub 2020 Sep 24.
• [838] Evaluation of gene induction of drug-metabolizing enzymes and transporters in primary culture of human hepatocytes using high-sensitivity real-time reverse transcription PCR. Yakugaku Zasshi. 2002 May;122(5):339-61.
• [839] RNAi-mediated knockdown of aldehyde dehydrogenase class-1A1 and class-3A1 is specific and reveals that each contributes equally to the resistance against 4-hydroperoxycyclophosphamide. Cancer Chemother Pharmacol. 2007 Jan;59(1):127-36. doi: 10.1007/s00280-006-0233-6. Epub 2006 Apr 14.
• [840] RLIP76 (RALBP1)-mediated transport of leukotriene C4 (LTC4) in cancer cells: implications in drug resistance. Int J Cancer. 2004 Dec 20;112(6):934-42. doi: 10.1002/ijc.20516.
• [841] Depletion of RLIP76 sensitizes lung cancer cells to doxorubicin. Biochem Pharmacol. 2005 Aug 1;70(3):481-8. doi: 10.1016/j.bcp.2005.05.005.
• [842] Simvastatin maintains steady patterns of GFR and improves AER and expression of slit diaphragm proteins in type II diabetes. Kidney Int. 2006 Jul;70(1):177-86. doi: 10.1038/sj.ki.5001515. Epub 2006 May 17.
• [843] Ciprofloxacin mediates cancer stem cell phenotypes in lung cancer cells through caveolin-1-dependent mechanism. Chem Biol Interact. 2016 Apr 25;250:1-11.
• [844] Inhibition of aldehyde dehydrogenase-1 and p-glycoprotein-mediated multidrug resistance by curcumin and vitamin D3 increases sensitivity to paclitaxel in breast cancer. Chem Biol Interact. 2020 Jan 5;315:108865. doi: 10.1016/j.cbi.2019.108865. Epub 2019 Oct 16.
• [845] The interaction of disulfiram and H(2)S metabolism in inhibition of aldehyde dehydrogenase activity and liver cancer cell growth. Toxicol Appl Pharmacol. 2021 Sep 1;426:115642. doi: 10.1016/j.taap.2021.115642. Epub 2021 Jul 6.
• [846] Inhibition of angiogenesis by quercetin in tamoxifen-resistant breast cancer cells. Food Chem Toxicol. 2010 Nov;48(11):3227-34. doi: 10.1016/j.fct.2010.08.028. Epub 2010 Sep 4.
• [847] Gene expression profile changes in NB4 cells induced by arsenic trioxide. Acta Pharmacol Sin. 2003 Jul;24(7):646-50.
• [848] Astaxanthin and omega-3 fatty acids individually and in combination protect against oxidative stress via the Nrf2-ARE pathway. Food Chem Toxicol. 2013 Dec;62:869-75.
• [849] Simulation of interindividual differences in inactivation of reactive para-benzoquinone imine metabolites of diclofenac by glutathione S-transferases in human liver cytosol. Toxicol Lett. 2016 Jul 25;255:52-62.
• [850] Expression of glutathione S-transferase M2 in stage I/II non-small cell lung cancer and alleviation of DNA damage exposure to benzo[a]pyrene. Toxicol Lett. 2010 Feb 15;192(3):316-23. doi: 10.1016/j.toxlet.2009.11.003. Epub 2009 Nov 10.
• [851] Indomethacin activates carbonic anhydrase and antagonizes the effect of the specific carbonic anhydrase inhibitor acetazolamide, by a direct mechanism of action. Int J Clin Pharmacol Ther. 2001 Jun;39(6):265-70.
• [852] Effects of beta-adrenergic agonists on bone-resorbing activity in human osteoclast-like cells. Biochim Biophys Acta. 2003 May 12;1640(2-3):137-42.
• [853] Inhibition profiling of human carbonic anhydrase II by high-throughput screening of structurally diverse, biologically active compounds. J Biomol Screen. 2006 Oct;11(7):782-91.
• [854] Design, synthesis, and biological evaluation of novel carbohydrate-based sulfamates as carbonic anhydrase inhibitors. J Med Chem. 2011 Mar 10;54(5):1481-9.
• [855] Inhibition profiles of Voriconazole against acetylcholinesterase, -glycosidase, and human carbonic anhydrase I and II isoenzymes. J Biochem Mol Toxicol. 2019 Oct;33(10):e22385. doi: 10.1002/jbt.22385. Epub 2019 Sep 3.
• [856] Rescue of Pink1 Deficiency by Stress-Dependent Activation of Autophagy. Cell Chem Biol. 2017 Apr 20;24(4):471-480.e4. doi: 10.1016/j.chembiol.2017.03.005. Epub 2017 Mar 30.
• [857] Metabolomics of oxidative stress: Nrf2 independent depletion of NAD or increases of sugar alcohols. Toxicol Appl Pharmacol. 2022 May 1;442:115949. doi: 10.1016/j.taap.2022.115949. Epub 2022 Feb 25.
• [858] A systems biology understanding of the synergistic effects of arsenic sulfide and Imatinib in BCR/ABL-associated leukemia. Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3378-83.
• [859] The enzymatic activity of human aldehyde dehydrogenases 1A2 and 2 (ALDH1A2 and ALDH2) is detected by Aldefluor, inhibited by diethylaminobenzaldehyde and has significant effects on cell proliferation and drug resistance. Chem Biol Interact. 2012 Jan 5;195(1):52-60.
• [860] Influence of glutathione S-transferase A1, P1, M1, T1 polymorphisms on oral busulfan pharmacokinetics in children with congenital hemoglobinopathies undergoing hematopoietic stem cell transplantation. Pediatr Blood Cancer. 2010 Dec 1;55(6):1172-9. doi: 10.1002/pbc.22739.
• [861] The influence of coordinate overexpression of glutathione phase II detoxification gene products on drug resistance. J Pharmacol Exp Ther. 2000 Aug;294(2):480-7.
• [862] Cell-type-specific responses to chemotherapeutics in breast cancer. Cancer Res. 2004 Jun 15;64(12):4218-26.
• [863] Glutathione S-transferase pi as a target for tricyclic antidepressants in human brain. Acta Biochim Pol. 2004;51(1):207-12.
• [864] Reactive oxygen species regulate ceruloplasmin by a novel mRNA decay mechanism involving its 3'-untranslated region: implications in neurodegenerative diseases. J Biol Chem. 2009 Jan 16;284(3):1873-83. doi: 10.1074/jbc.M804079200. Epub 2008 Nov 18.
• [865] DNA microarray analysis of vitamin D-induced gene expression in a human colon carcinoma cell line. Physiol Genomics. 2004 Apr 13;17(2):122-9. doi: 10.1152/physiolgenomics.00002.2003.
• [866] In vitro assessment of drug-induced liver steatosis based on human dermal stem cell-derived hepatic cells. Arch Toxicol. 2016 Mar;90(3):677-89. doi: 10.1007/s00204-015-1483-z. Epub 2015 Feb 26.
• [867] Identification of approved drugs as potent inhibitors of pregnane X receptor activation with differential receptor interaction profiles. Arch Toxicol. 2018 Apr;92(4):1435-1451.
• [868] Oxidative stress mechanisms do not discriminate between genotoxic and nongenotoxic liver carcinogens. Chem Res Toxicol. 2015 Aug 17;28(8):1636-46.
• [869] Posttranslational glutathiolation of aldose reductase (AKR1B1): a possible mechanism of protein recovery from S-nitrosylation. Chem Biol Interact. 2009 Mar 16;178(1-3):250-8. doi: 10.1016/j.cbi.2008.11.007. Epub 2008 Nov 18.
• [870] Aldo-keto reductase 1C2 fails to metabolize doxorubicin and daunorubicin in vitro. Drug Metab Dispos. 2008 Jun;36(6):991-4. doi: 10.1124/dmd.108.020388. Epub 2008 Mar 5.