Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM30SGU)

• Drug Name: Simvastatin Drug Info
• Synonyms: Cholestat; Coledis; Colemin; Corolin; Denan; Labistatin; Lipex; Lipovas; Lodales; Medipo; Nivelipol; Pantok; Rendapid; Simovil; Simvastatina; Simvastatine; Simvastatinum; Sinvacor; Sivastin; Synvinolin; Vasotenal; Zocor; Zocord; Simvast CR; Simvastatina [Spanish]; Simvastatine [French]; Simvastatinum [Latin]; MK 0733; MK 733; MK733; TNP00259; DRG-0320; KS-1113; L 644128-000U; MK-0733; MK-733; Simcard (TN); Simlup (TN); Simvacor (TN); Simvastatin & Primycin; Simvastatin, Compactin; Zocor (TN); Simvastatin [USAN:INN:BAN]; Simvastatin (JAN/USP/INN); Zocor, Simlup, Simcard, Simvacor, Simvoget, Zorced, Simvastatin; [(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoate; Butanoic acid, 2,2-dimethyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester; Butanoic acid, 2,2-dimethyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-((2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester; Butanoic acid, 2,2-dimethyl-, (1S,3R,7S,8S,*aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-((2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester; (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate; Butanoic acid, 2,2-dimethyl-,1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)-ethyl]-1-naphthalenyl ester, [1S-[1 alpha,3 alpha,7 beta,8 beta(2S*,4S*),-8a beta; 2,2-Dimethylbutanoic acid (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester; 2,2-Dimethylbutyric acid, 8-ester with (4R,6R)-6-(2-((1S,2S,6R,8S,8aR)-1,2,6,7,8,8a-hexahydro-8-hydroxy-2,6-dimethyl-1-naphthyl)ethyl)tetrahydro-4-hydroxy-2H-pyran-2-one

Indication

Disease Entry	ICD 11	Status	REF
Arteriosclerosis	BD40	Approved	[1]
Atherosclerosis	BD40	Approved	[1]
Coronary heart disease	BA80.Z	Approved	[1]
Cystic fibrosis	CA25	Approved	[1]
Depression	6A70-6A7Z	Approved	[1]
Hypercholesterolaemia	5C80.0	Approved	[2]
Hyperlipidemia	5C80.Z	Approved	[1]
Hyperlipidemia, familial combined, LPL related		Approved	[1]
Hypertriglyceridemia	5C80.1	Approved	[1]
Pneumonia	CA40	Approved	[1]
Primary hypercholesterolemia	5C80.00	Approved	[1]
Prostate carcinoma		Approved	[1]
Rhinitis	FA20	Approved	[1]
Type-1/2 diabetes	5A10-5A11	Approved	[1]
Stroke	8B20	Investigative	[1]

• Therapeutic Class: Anticholesteremic Agents
• Cross-matching ID:
  PubChem CID: 54454
  ChEBI ID: CHEBI:9150
  CAS Number: CAS 79902-63-9
  TTD Drug ID: DM30SGU
  VARIDT Drug ID: DR00435
  INTEDE Drug ID: DR1485
  ACDINA Drug ID: D00625

Molecule-Related Drug Atlas

Drug(s) Targeting HMG-CoA reductase (HMGCR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[19]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[3]
Cerivastatin	DMXCM7H	Hyperlipidaemia	5C80	Approved	[20]
PITAVASTATIN CALCIUM	DM1UJO0	Dyslipidemia	5C80-5C81	Approved	[21]
Rosuvastatin	DMMIQ7G	Arteriosclerosis	BD40	Approved	[22]
Fluvastatin	DM4MDJY	Arteriosclerosis	BD40	Approved	[3]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[23]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[24]
Teriflunomide	DMQ2FKJ	Hyperlipidaemia	5C80	Approved	[23]
TOCOTRIENOL	DM1UE67	Hyperlipidaemia	5C80	Approved	[25]

Drug(s) Transported By P-glycoprotein 1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[4]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[6]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[27]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[6]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[6]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[28]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[6]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[29]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[30]

Drug(s) Transported By Breast cancer resistance protein (ABCG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[31]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[32]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[33]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[34]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[35]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[36]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[37]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[36]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[38]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[39]

Drug(s) Transported By Organic anion transporting polypeptide 1B1 (SLCO1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[40]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[41]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[42]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[43]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[42]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[44]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[45]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[46]
Cerivastatin	DMXCM7H	Hyperlipidaemia	5C80	Approved	[47]
PITAVASTATIN CALCIUM	DM1UJO0	Dyslipidemia	5C80-5C81	Approved	[44]

Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[49]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[50]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[51]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[52]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[53]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[54]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[55]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[49]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[56]
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[117]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[118]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[119]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[120]
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[121]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[121]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[122]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[123]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[124]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[125]

Drug(s) Metabolized By UDP-glucuronosyltransferase 1A1 (UGT1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[57]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[58]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[60]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[63]
Metronidazole	DMTIVEN	Abscess		Approved	[64]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[65]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[66]

Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[67]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[68]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[69]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[52]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[56]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[70]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[71]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[72]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[73]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[74]

Drug(s) Metabolized By Cytochrome P450 3A5 (CYP3A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[75]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[76]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[77]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[78]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[79]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[80]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[81]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[82]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[83]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[78]
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[117]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[118]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[123]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[123]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[126]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[127]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[128]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[131]

Drug(s) Metabolized By Cytochrome P450 2C8 (CYP2C8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[84]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[85]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[85]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[86]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[87]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[88]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[89]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[85]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[90]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[91]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[111]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[112]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[111]
Sulfinpyrazone	DMEV954	Gout	FA25	Approved	[113]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[112]
Zafirlukast	DMHNQOG	Asthma	CA23	Approved	[112]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[112]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[114]
Dabrafenib	DMX6OE3	Melanoma	2C30	Approved	[115]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[116]

Drug(s) Metabolized By Mephenytoin 4-hydroxylase (CYP2C19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[92]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[93]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[94]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[95]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[86]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[96]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[99]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[91]

Drug(s) Metabolized By UDP-glucuronosyltransferase 2B7 (UGT2B7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[100]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[101]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[102]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[90]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[56]
PITAVASTATIN CALCIUM	DM1UJO0	Dyslipidemia	5C80-5C81	Approved	[103]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[104]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[105]
Losartan	DM72JXH	Diabetic kidney disease	GB61.Z	Approved	[56]

Drug(s) Metabolized By UDP-glucuronosyltransferase 1A3 (UGT1A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[106]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[56]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[107]
Cerivastatin	DMXCM7H	Hyperlipidaemia	5C80	Approved	[108]
PITAVASTATIN CALCIUM	DM1UJO0	Dyslipidemia	5C80-5C81	Approved	[103]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[104]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[109]
Losartan	DM72JXH	Diabetic kidney disease	GB61.Z	Approved	[56]
Naproxen	DMZ5RGV	Bursitis		Approved	[110]

Drug(s) Affected By Solute carrier organic anion transporter family member 1B1 (SLCO1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Enalapril	DMNFUZR	Congestive heart failure	BD10	Approved	[132]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[133]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[134]
Repaglinide	DM5SXUV	Diabetic complication	5A2Y	Approved	[135]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[136]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[137]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[137]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[138]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[139]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[140]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[141]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[142]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[143]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[144]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[145]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[146]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[147]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[148]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[149]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[147]

Drug(s) Affected By Stromelysin-1 (MMP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluvastatin	DM4MDJY	Arteriosclerosis	BD40	Approved	[150]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[150]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[150]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[152]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[153]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[154]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[155]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[156]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[157]

Drug(s) Affected By Apolipoprotein E (APOE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[158]
Selenium	DM25CGV	N. A.	N. A.	Approved	[159]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[161]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[163]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[164]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[165]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]

Drug(s) Affected By 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[166]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[167]
Digoxin	DMQCTIH	Arrhythmia	BC9Z	Approved	[150]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[168]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[169]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[170]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[161]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[171]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]

Drug(s) Affected By ATP-binding cassette sub-family C member 2 (ABCC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lopinavir	DMITQS0	Human immunodeficiency virus infection	1C62	Approved	[173]
Sulfinpyrazone	DMEV954	Gout	FA25	Approved	[174]
Probenecid	DMMFWOJ	Acute gonococcal cervicitis		Approved	[175]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[176]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[177]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[178]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[179]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[180]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[181]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[182]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[183]
Vidarabine	DM0N85H	Hepatosplenic T-cell lymphoma		Approved	[183]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[184]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[185]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[186]
Etidronic acid	DM1XHYJ	Bone Paget disease		Approved	[183]
Tiaprofenic acid	DM23D7J	Osteoarthritis	FA00-FA05	Approved	[183]
Bromperidol	DM24XYQ	Schizophrenia	6A20	Approved	[183]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[187]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[188]

Drug(s) Affected By Cytochrome P450 2B6 (CYP2B6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[189]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[190]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[191]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[192]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[193]
Clopidogrel	DMOL54H	Acute coronary syndrome	BA41	Approved	[194]
Artemisinin	DMOY7W3	Malaria	1F40-1F45	Approved	[195]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[196]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[197]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[198]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 3 (NR1I3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[199]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[200]
Artemether	DM48QOT	Malaria	1F40-1F45	Approved	[201]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[202]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[203]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[204]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[205]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[206]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[205]

Drug(s) Affected By Prostaglandin E synthase (PTGES)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[207]
Selenium	DM25CGV	N. A.	N. A.	Approved	[159]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[208]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[209]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[210]
Mestranol	DMG3F94	Contraception	QA21	Approved	[207]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[211]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[212]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[207]

Drug(s) Affected By Myeloperoxidase (MPO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[150]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[213]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[150]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[150]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[214]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[215]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[216]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[217]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[218]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[219]

Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[220]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[221]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[222]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[223]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[224]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[225]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[226]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[227]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[228]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[161]

Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[229]
Selenium	DM25CGV	N. A.	N. A.	Approved	[159]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[230]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[231]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[232]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[233]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[234]
Desloratadine	DM56YN7	Allergic rhinitis	CA08.0	Approved	[235]

Drug(s) Affected By Advanced glycosylation end product-specific receptor (AGER)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[236]
TRIENTINE	DMD2WPG	Inborn error of metabolism	5C50-5C59	Approved	[237]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[238]
Mebendazole	DMO14SG	Ascariasis	1F62	Approved	[239]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[240]
Estriol	DMOEM2I	Hormone deficiency	5A61.1	Approved	[240]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[238]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[241]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[242]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[240]

Drug(s) Affected By CCN family member 1 (CCN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[168]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[243]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[244]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[243]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[245]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[246]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[247]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[248]

Drug(s) Affected By Aurora kinase A (AURKA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[249]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[250]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[251]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[252]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[253]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[251]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[254]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[254]

Drug(s) Affected By Cell division control protein 45 homolog (CDC45)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[255]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[228]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[256]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[257]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[254]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[254]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[258]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[259]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[260]

Drug(s) Affected By Integrin beta-like protein 1 (ITGBL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[252]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[261]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[262]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[263]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[261]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[264]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[265]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[266]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[267]
PD-0325901	DM27D4J	Breast cancer	2C60-2C65	Phase 2	[268]

Drug(s) Affected By Protein S100-A8 (S100A8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[238]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[238]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[269]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[269]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[257]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[270]
Halothane	DM80OZ5	Anaesthesia	9A78.6	Approved	[238]
Dicloxacillin	DM8EU0Z	Bacterial infection	1A00-1C4Z	Approved	[238]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[247]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]

Drug(s) Affected By Integrin beta-1 (ITGB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[271]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[272]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[224]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[273]
Fructose	DM43AN2	Vomiting	MD90	Approved	[274]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[163]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[275]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[276]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[277]

Drug(s) Affected By Cyclin-dependent kinase 1 (CDK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[255]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[278]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[279]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[250]
Selenium	DM25CGV	N. A.	N. A.	Approved	[280]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[281]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[230]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[282]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[283]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]

Drug(s) Affected By Protein S100-A9 (S100A9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[238]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[284]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[269]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[269]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[285]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[286]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[270]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[287]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]

Drug(s) Affected By Protein S100-A6 (S100A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[288]
Selenium	DM25CGV	N. A.	N. A.	Approved	[159]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[286]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[289]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[290]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[291]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[258]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[292]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[293]

Drug(s) Affected By Thrombospondin-1 (THBS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[294]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[152]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[284]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[295]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[269]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[243]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[269]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[296]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[297]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[298]

Drug(s) Affected By Stromelysin-2 (MMP10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[129]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[299]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[243]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[269]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[243]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[269]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[297]
Haloperidol	DM96SE0	Delirium		Approved	[300]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]

Drug(s) Affected By Proliferating cell nuclear antigen (PCNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[299]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[301]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[302]
Selenium	DM25CGV	N. A.	N. A.	Approved	[280]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[169]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[303]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[304]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[282]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[305]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[283]

Drug(s) Affected By Annexin A3 (ANXA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[261]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[244]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[289]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[306]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[254]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[261]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[254]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[248]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[307]

Drug(s) Affected By Keratin, type I cytoskeletal 13 (KRT13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[308]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[309]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[290]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[306]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[310]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[311]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[312]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[313]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[314]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[315]

Drug(s) Affected By 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (PLCG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[316]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[317]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[292]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[265]
Ibrutinib	DMHZCPO	Mantle cell lymphoma	2A85.5	Approved	[318]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[319]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[319]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[320]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[321]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-3 (ATF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[322]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[168]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[251]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[323]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[324]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[116]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[325]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[289]

Drug(s) Affected By Keratin, type I cytoskeletal 15 (KRT15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[250]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[269]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[269]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[264]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[326]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[258]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[326]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[326]

Drug(s) Affected By Cyclin-A2 (CCNA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[327]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[278]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[301]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[168]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[303]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[328]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[252]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[329]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[330]

Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[331]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[332]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[229]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[333]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[334]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[335]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[336]
Selenium	DM25CGV	N. A.	N. A.	Approved	[159]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[337]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[338]

Drug(s) Affected By Insulin-like growth factor-binding protein 6 (IGFBP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[159]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[282]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[339]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[340]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[341]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[258]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[342]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[210]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[212]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[343]

Drug(s) Affected By Calmodulin-like protein 3 (CALML3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[344]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[306]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[264]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Seocalcitol	DMKL9QO	Rickets	5B57	Phase 3	[345]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[315]

Drug(s) Affected By Gap junction beta-2 protein (GJB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[346]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[254]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[264]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[292]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[347]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[212]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[348]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[182]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[311]

Drug(s) Affected By Tyrosine-protein kinase receptor UFO (AXL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[159]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[349]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[349]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[350]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[248]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[326]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[326]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[326]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[351]

Drug(s) Affected By Aldehyde dehydrogenase, dimeric NADP-preferring (ALDH3A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[352]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[353]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[306]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[248]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[354]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[212]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[241]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[355]

Drug(s) Affected By DNA replication licensing factor MCM4 (MCM4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[255]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[224]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[228]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[244]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[245]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[254]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[254]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[356]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[357]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[358]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[359]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[272]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[360]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[335]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[168]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[281]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[361]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[362]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[363]

Drug(s) Affected By Macrophage metalloelastase (MMP12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[243]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[243]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[257]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[254]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[254]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[243]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[364]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[243]

Drug(s) Affected By Replication factor C subunit 5 (RFC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[255]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[233]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[260]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[293]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[300]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[365]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[366]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[367]

Drug(s) Affected By Regulator of G-protein signaling 2 (RGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[250]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[284]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[163]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[276]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[297]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[236]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[368]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[307]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[369]

Drug(s) Affected By Collagenase 3 (MMP13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[370]
Clindamycin	DM15HL8	Acne vulgaris	ED80	Approved	[371]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[370]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[372]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[373]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[263]
Doxycycline	DM7ICNU	Acne vulgaris	ED80	Approved	[371]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[368]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[345]
Prinomastat	DM9HOKG	Lung cancer	2C25.0	Approved	[374]

Drug(s) Affected By DNA primase small subunit (PRIM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[255]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[252]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[254]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[254]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[259]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[260]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1C (CDKN1C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[250]
Selenium	DM25CGV	N. A.	N. A.	Approved	[159]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[283]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[269]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[269]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[306]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[307]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[375]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[376]

Drug(s) Affected By Transcription factor E2F1 (E2F1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[377]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[299]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[378]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[379]
Selenium	DM25CGV	N. A.	N. A.	Approved	[159]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[363]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[328]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[269]

Drug(s) Affected By Collagen alpha-1(VII) chain (COL7A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[380]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[164]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[296]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[292]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[381]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[382]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[364]

Drug(s) Affected By Keratin, type I cytoskeletal 17 (KRT17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[383]
Selenium	DM25CGV	N. A.	N. A.	Approved	[159]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[269]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[269]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[383]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[248]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[258]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[269]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[384]

Drug(s) Affected By Aldo-keto reductase family 1 member C1 (AKR1C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[385]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[386]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[387]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[388]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[386]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[386]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[389]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[388]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[386]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[390]

Drug(s) Affected By Focal adhesion kinase 1 (PTK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[391]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[392]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[393]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[340]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[394]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[395]
Halothane	DM80OZ5	Anaesthesia	9A78.6	Approved	[396]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[307]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[292]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[293]

Drug(s) Affected By Lymphotoxin-beta (LTB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[397]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[398]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[248]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[399]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Sanguinarine	DMDINFS	Dental plaque	DA08.4	Approved	[397]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[347]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[400]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[401]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[213]

Drug(s) Affected By BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[224]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[325]
Quinolones	DM5GVHU	Bacterial infection	1A00-1C4Z	Approved	[402]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[403]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[246]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[236]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[326]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]

Drug(s) Affected By Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[255]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[279]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[404]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[244]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[405]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[254]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[254]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[293]

Drug(s) Affected By Centromere protein R (ITGB3BP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[406]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[258]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[365]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[212]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[364]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[407]

Drug(s) Affected By Rho GTPase-activating protein 29 (ARHGAP29)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[250]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[408]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[261]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[248]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[307]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[293]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[409]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[364]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[410]

Drug(s) Affected By Interleukin-20 receptor subunit beta (IL20RB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[250]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[289]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[263]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[411]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[260]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[382]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[364]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[319]

Drug(s) Affected By Bcl-2-binding component 3, isoforms 3/4 (BBC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[250]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[412]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[251]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[413]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[414]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[415]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[416]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[397]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[417]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[418]

Drug(s) Affected By Krueppel-like factor 6 (KLF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[299]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[419]
Selenium	DM25CGV	N. A.	N. A.	Approved	[159]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[363]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[289]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[248]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[292]

Drug(s) Affected By Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (PKMYT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[255]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[245]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[254]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[254]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[420]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[364]

Drug(s) Affected By Cell division control protein 6 homolog (CDC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[255]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[363]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[404]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[233]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[421]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[254]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[254]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[292]

Drug(s) Affected By Spondin-2 (SPON2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[208]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[257]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[264]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[182]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[422]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[423]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[424]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[321]

Drug(s) Affected By Rac GTPase-activating protein 1 (RACGAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[249]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[406]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[254]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[254]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[248]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[260]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[293]

Drug(s) Affected By DNA replication factor Cdt1 (CDT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[299]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[157]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[254]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[254]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[259]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[260]

Drug(s) Affected By Matrix metalloproteinase-28 (MMP28)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[163]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[285]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[342]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[241]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[425]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[426]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[423]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[427]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[428]

Drug(s) Affected By Alpha-catulin (CTNNAL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[429]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[233]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[164]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[297]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[259]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[430]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[212]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[364]

Drug(s) Affected By Protein DBF4 homolog A (DBF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[255]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[288]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[254]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[254]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[292]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[431]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[364]

Drug(s) Affected By Krueppel-like factor 2 (KLF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[284]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[263]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[306]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[270]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[432]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[364]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[319]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[241]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[182]

Drug(s) Affected By Catalase (CAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[433]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[434]
Haloperidol	DM96SE0	Delirium		Approved	[150]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[435]
Selenium	DM25CGV	N. A.	N. A.	Approved	[436]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[437]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[438]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[284]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[339]

Drug(s) Affected By Sterol regulatory element-binding protein 1 (SREBF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[150]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[271]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[439]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[440]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[161]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[441]
Vemurafenib	DM62UG5	Melanoma	2C30	Approved	[442]

Drug(s) Affected By NPC1-like intracellular cholesterol transporter 1 (NPC1L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[443]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[444]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[354]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[347]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[182]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[445]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[446]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[408]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[447]

Drug(s) Affected By Signal transducer CD24 (CD24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[249]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[443]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[289]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[448]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[254]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[254]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[289]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[212]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[449]

Drug(s) Affected By Aldo-keto reductase family 1 member C3 (AKR1C3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[450]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[386]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[387]
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[451]
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[451]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[386]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[386]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[452]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[163]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[389]

Drug(s) Affected By Killer cell immunoglobulin-like receptor 2DS2 (KIR2DS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[443]

Drug(s) Affected By Killer cell lectin-like receptor subfamily F member 1 (KLRF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[453]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[315]
CHOLINE	DM5D9YK	Insomnia	7A00-7A0Z	Investigative	[454]

Drug(s) Affected By Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHUK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[455]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[456]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[457]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[297]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[458]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[258]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[459]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[293]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[460]

Drug(s) Affected By ATP-binding cassette sub-family C member 3 (ABCC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[181]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[461]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[462]
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[463]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[464]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[301]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[250]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[465]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[466]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[179]

Drug(s) Affected By NF-kappa-B inhibitor alpha (NFKBIA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fructose	DM43AN2	Vomiting	MD90	Approved	[150]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[467]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[468]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[469]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[470]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[471]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[231]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[339]

Drug(s) Affected By Methylenetetrahydrofolate reductase (MTHFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[472]
Benazepril	DMH1M9B	Hypertension	BA00-BA04	Approved	[473]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[474]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[163]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[254]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[254]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[182]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[311]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[475]

Drug(s) Affected By Sphingosine 1-phosphate receptor 1 (S1PR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[297]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[236]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[292]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[212]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[476]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[477]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[478]
GSK618334	DMJPXZ4	Drug abuse	6C4G.1Z	Phase 1	[479]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[315]

Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[480]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[481]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[482]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[483]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[484]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[485]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[486]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[294]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[487]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[488]

Drug(s) Affected By Bile salt export pump (ABCB11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[489]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[490]
Glipizide	DMZA5PQ	Diabetic complication	5A2Y	Approved	[490]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[134]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[489]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[490]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[491]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[489]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[492]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[489]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[468]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[493]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[487]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[433]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[487]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[494]
Selenium	DM25CGV	N. A.	N. A.	Approved	[495]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[496]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[497]

Drug(s) Affected By Delta(24)-sterol reductase (DHCR24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[159]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[170]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[344]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[498]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[264]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[292]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[293]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[300]

Drug(s) Affected By Farnesyl pyrophosphate synthase (FDPS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[161]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[344]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[405]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[293]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[499]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[364]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[213]

Drug(s) Affected By Squalene synthase (FDFT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[170]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[163]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[344]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[248]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[500]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[354]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[293]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[501]

Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[326]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[502]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[464]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[433]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[503]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[504]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[505]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[506]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[261]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]

Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[507]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[508]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[222]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[433]
Selenium	DM25CGV	N. A.	N. A.	Approved	[159]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[509]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[505]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[510]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[161]

Drug(s) Affected By Toll-like receptor 4 (TLR4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[284]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[511]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[244]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[297]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[512]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[513]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[514]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[326]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[259]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[294]
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[515]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[516]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[517]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[404]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[116]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[244]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[289]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[518]

Drug(s) Affected By Dynamin-1-like protein (DNM1L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[519]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[520]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[258]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[521]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[293]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[522]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[523]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[519]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[524]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[525]

Drug(s) Affected By Suppressor of cytokine signaling 7 (SOCS7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[258]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[292]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[526]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[527]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[450]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[526]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[321]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[315]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[528]

Drug(s) Affected By Suppressor of cytokine signaling 3 (SOCS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[294]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[250]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[443]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[261]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[269]
Fedratinib	DM4ZBK6	Myelofibrosis	2A20.2	Approved	[529]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[289]
Pyrimethamine	DM5X7VY	Malaria	1F40-1F45	Approved	[529]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[261]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[530]

Drug(s) Affected By Inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[470]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[531]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[163]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[470]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[532]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[236]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Ibrutinib	DMHZCPO	Mantle cell lymphoma	2A85.5	Approved	[533]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[534]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[535]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[279]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[360]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[536]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[412]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[281]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[251]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[537]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[538]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[539]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[540]

Drug(s) Affected By Transmembrane protease serine 2 (TMPRSS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[541]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[541]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[250]
Selenium	DM25CGV	N. A.	N. A.	Approved	[159]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[541]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[541]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[541]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[541]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[541]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[208]

Drug(s) Affected By CASP8 and FADD-like apoptosis regulator (CFLAR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[271]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[542]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[543]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[544]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[228]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[539]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[244]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[545]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[546]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[547]

Drug(s) Affected By Serine protease HTRA2, mitochondrial (HTRA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[507]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[164]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[254]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[254]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[292]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[293]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[548]
Bortezomib	DMNO38U	Leukemia		Approved	[549]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[550]

Drug(s) Affected By Alpha-actinin-4 (ACTN4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[159]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[293]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[551]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[212]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[311]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[450]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[159]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[552]

Drug(s) Affected By E3 ubiquitin-protein ligase MARCHF6 (MARCHF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[292]
Betaine	DMGRZW2	Cystitis	GC00	Approved	[553]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[554]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[555]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[426]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[477]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[159]
ANW-32821	DMMJOZD	N. A.	N. A.	Phase 2	[553]
CB-5083	DM12GN7	Multiple myeloma	2A83	Phase 1	[553]

Drug(s) Affected By Nephrin (NPHS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[556]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[557]
Bezafibrate	DMZDCS0	Hypercholesterolaemia	5C80.0	Approved	[558]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[423]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[314]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[315]
PIRINIXIC ACID	DM82Y75	Pulmonary fibrosis	CB03.4	Preclinical	[558]
Puromycin	DMDKLB5	N. A.	N. A.	Preclinical	[559]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[560]

Drug(s) Affected By Toll-like receptor 2 (TLR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[243]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[511]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[243]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[561]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[562]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[512]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[514]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[563]

Drug(s) Affected By Apolipoprotein M (APOM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[250]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[411]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[364]
Chenodiol	DMQ8JIK	Cholelithiasis	DC11	Approved	[564]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[159]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[427]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[565]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[566]

Drug(s) Affected By Phospholipid-transporting ATPase ABCA1 (ABCA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[567]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[170]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[161]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[568]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[569]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[570]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[571]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[441]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[572]

Drug(s) Affected By Prothrombin (F2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[573]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[284]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[574]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[575]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[576]
Phytonadione	DM8HDOL	Bleeding disorder	GA20-GA21	Approved	[577]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[578]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[579]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[342]

Drug(s) Affected By Tissue-type plasminogen activator (PLAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[152]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[580]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[581]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[582]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[282]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[156]
Fructose	DM43AN2	Vomiting	MD90	Approved	[274]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[269]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[269]

Drug(s) Affected By Angiotensinogen (AGT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[583]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[584]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[250]
Reboxetine	DM26PRD	Depression	6A70-6A7Z	Approved	[585]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[586]
Rhucin	DM3ADGP	Erectile dysfunction	HA01.1	Approved	[587]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]
Lisinopril	DMUOK4C	Chronic heart failure	BD1Z	Approved	[588]
Irbesartan	DMTP1DC	Diabetic kidney disease	GB61.Z	Approved	[589]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[590]

Drug(s) Affected By Protein c-Fos (FOS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[245]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[359]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[591]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[222]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[591]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[301]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[224]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[592]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[593]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[594]

Drug(s) Affected By GTPase KRas (KRAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[595]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[344]
Tiazofurin	DM5JWV9	Solid tumour/cancer	2A00-2F9Z	Approved	[596]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[597]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[598]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[599]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[600]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[601]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[357]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[293]

Drug(s) Affected By Platelet-derived growth factor subunit B (PDGFB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[464]
Ramipril	DM2R68E	Acute heart failure	BD10-BD13	Approved	[602]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[284]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[603]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[604]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[258]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[603]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[605]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[267]

Drug(s) Affected By Low-density lipoprotein receptor (LDLR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[606]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[168]
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[606]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[607]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[161]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[116]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[608]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[344]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[499]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[609]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[610]
Fructose	DM43AN2	Vomiting	MD90	Approved	[150]
Ketoprofen	DMRKXPT	Bursitis		Approved	[150]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[611]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[612]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[613]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[614]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[615]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[616]

Drug(s) Affected By Interferon gamma (IFNG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[425]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[617]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[618]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[619]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[284]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[620]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[621]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[622]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[623]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[624]

Drug(s) Affected By Interleukin-2 receptor subunit alpha (IL2RA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[443]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[625]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[626]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[627]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[628]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[629]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[514]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[265]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[630]

Drug(s) Affected By HLA class II histocompatibility antigen, DQ beta 1 chain (HLA-DQB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[631]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[632]
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[632]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[633]
Allopurinol	DMLPAOB	Gout	FA25	Approved	[634]
Ticlopidine	DMO946V	Acute coronary syndrome	BA41	Approved	[635]
Selenium	DM25CGV	N. A.	N. A.	Approved	[159]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[208]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[344]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[632]

Drug(s) Affected By Collagen alpha-1(I) chain (COL1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[150]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[636]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[380]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[271]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[637]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[638]
Ceruletide	DM2WE5K	Caerulein stimulated gastric and pancreatic secretion	5A4Y	Approved	[639]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[640]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[641]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[161]

Drug(s) Affected By Collagen alpha-1(III) chain (COL3A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[636]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[642]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[643]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[644]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[244]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[645]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[646]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[264]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[647]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[513]

Drug(s) Affected By Apolipoprotein A-I (APOA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[648]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[161]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[649]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[650]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[651]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[652]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[354]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[653]
Gemfibrozil	DMD8Q3J	Hyperlipidaemia	5C80	Approved	[654]

Drug(s) Affected By C-reactive protein (CRP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lidocaine	DML4ZOT	Anaesthesia	9A78.6	Approved	[150]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[655]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[656]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[161]
Acalabrutinib	DM7GCVW	leukaemia	2A60-2B33	Approved	[657]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[658]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[659]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[660]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[236]
Milrinone	DM8TUPF	Congestive heart failure	BD10	Approved	[661]

Drug(s) Affected By Alpha-fetoprotein (AFP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[662]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[169]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[244]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[662]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[575]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[663]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[258]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[292]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[551]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[605]

Drug(s) Affected By Transferrin receptor protein 1 (TFRC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[272]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[664]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[665]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[261]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[256]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[344]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[325]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[547]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[666]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[667]

Drug(s) Affected By Osteocalcin (BGLAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[668]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[669]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[637]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[670]
Pamidronate	DMB4AVP	Bone Paget disease		Approved	[671]
Falecalcitrol	DMBI9ZJ	Hyperparathyroidism	5A51	Approved	[672]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[673]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[351]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[674]

Drug(s) Affected By Interstitial collagenase (MMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[255]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[675]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[676]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[153]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[282]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[677]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[156]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[678]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[285]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[306]

Drug(s) Affected By RAF proto-oncogene serine/threonine-protein kinase (RAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[327]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[644]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[679]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[245]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[680]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[681]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[682]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[683]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[368]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[684]

Drug(s) Affected By Apolipoprotein B-100 (APOB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[685]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[250]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[685]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[161]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[685]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[686]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[685]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[687]
Bendroflumethiazide	DM7EVLC	High blood pressure	BA00	Approved	[688]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[689]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[284]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[690]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[691]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[692]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[693]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[694]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[695]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[696]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[697]

Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[698]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[699]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[700]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[701]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[702]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[339]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[388]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[703]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[704]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[705]

Drug(s) Affected By Amyloid-beta precursor protein (APP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[224]
Selenium	DM25CGV	N. A.	N. A.	Approved	[159]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[284]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[706]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[707]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[662]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[245]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[708]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[709]

Drug(s) Affected By Integrin beta-2 (ITGB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[282]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[233]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[344]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[245]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[277]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[258]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[710]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[347]
Josamycin	DMKJ8LB	Bacterial infection	1A00-1C4Z	Approved	[711]

Drug(s) Affected By Interleukin-4 (IL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[712]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[713]
Tolnaftate	DM28MU7	Dermatophytosis	1F28.2	Approved	[714]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[715]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[716]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[717]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[619]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[284]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[718]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[620]

Drug(s) Affected By Plasminogen activator inhibitor 1 (SERPINE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[719]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[152]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[580]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[720]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[721]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[161]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[722]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[203]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[518]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[297]

Drug(s) Affected By Alkaline phosphatase, tissue-nonspecific isozyme (ALPL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[150]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[182]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[636]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[637]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[244]
Procaine	DM4LSNE	Anaesthesia	9A78.6	Approved	[723]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[670]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[672]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[724]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]

Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[243]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[725]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[299]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[726]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[727]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[468]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[616]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[494]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[728]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[243]

Drug(s) Affected By Endothelin-1 (EDN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[729]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[307]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[730]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[282]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[731]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[233]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[732]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[733]
Lisinopril	DMUOK4C	Chronic heart failure	BD1Z	Approved	[734]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[289]

Drug(s) Affected By Intercellular adhesion molecule 1 (ICAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[735]
Dicloxacillin	DM8EU0Z	Bacterial infection	1A00-1C4Z	Approved	[735]
Ergonovine	DM0VEC1	Postpartum haemorrhage	JA43	Approved	[150]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[736]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[737]
Mizolastine	DM1FDN8	Allergic rhinitis	CA08.0	Approved	[738]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[739]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[740]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[741]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[742]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[743]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[744]
Fructose	DM43AN2	Vomiting	MD90	Approved	[150]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[745]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[746]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[222]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[272]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[288]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[747]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[748]

Drug(s) Affected By Retinoblastoma-associated protein (RB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[749]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[750]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[751]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[335]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[224]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[752]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[328]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[753]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[283]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[754]

Drug(s) Affected By Thrombomodulin (THBD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[382]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[443]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[208]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[263]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[264]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[755]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[756]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[241]
Indomethacin	DMSC4A7	Bursitis		Approved	[757]

Drug(s) Affected By Calpain-1 catalytic subunit (CAPN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[758]
Selenium	DM25CGV	N. A.	N. A.	Approved	[159]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[759]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[760]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[761]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[762]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[763]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[293]

Drug(s) Affected By Heat shock protein HSP 90-alpha (HSP90AA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[764]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[294]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[493]
Selenium	DM25CGV	N. A.	N. A.	Approved	[159]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[665]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[703]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[293]

Drug(s) Affected By Insulin-like growth factor 1 receptor (IGF1R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[765]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[766]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[169]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[767]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[768]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[598]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[254]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[254]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[326]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[258]

Drug(s) Affected By Rho-related GTP-binding protein RhoC (RHOC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[163]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[769]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[770]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[270]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[258]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[771]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[357]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[293]
Terbinafine	DMI6HUW	Fungal infection	1F29-1F2F	Approved	[772]

Drug(s) Affected By 72 kDa type IV collagenase (MMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[675]
Selenium	DM25CGV	N. A.	N. A.	Approved	[773]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[774]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[775]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[776]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[344]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[777]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[778]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[779]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[780]

Drug(s) Affected By Fibroblast growth factor 2 (FGF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[781]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[359]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[380]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[782]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[783]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[244]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[164]
Isradipine	DMA5XGH	Hypertension	BA00-BA04	Approved	[784]
Valdecoxib	DMAY7H4	Osteoarthritis	FA00-FA05	Approved	[785]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[307]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[220]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[322]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[726]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[508]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[468]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[469]
Selenium	DM25CGV	N. A.	N. A.	Approved	[786]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[742]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[787]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[282]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[299]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[788]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[789]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[412]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[790]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[362]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[790]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[791]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[792]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[793]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[794]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[795]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[796]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[726]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[746]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[468]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[487]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[433]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[797]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[487]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[798]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[799]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[800]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[801]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[150]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[299]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[802]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[803]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[612]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[229]

Drug(s) Affected By Osteopontin (SPP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[636]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[294]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[516]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[767]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[804]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[233]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[805]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[289]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[662]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[561]

Drug(s) Affected By Microtubule-associated protein tau (MAPT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[758]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[806]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[469]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[807]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[264]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[248]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[600]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]

Drug(s) Affected By Endoplasmic reticulum chaperone BiP (HSPA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[758]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[685]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[808]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[809]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[810]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[811]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[812]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[813]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[814]

Drug(s) Affected By Cholesteryl ester transfer protein (CETP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[815]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[816]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[651]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Teniposide	DMLW57T	Acute lymphoblastic leukaemia	2A85	Approved	[815]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[817]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[815]
Bezafibrate	DMZDCS0	Hypercholesterolaemia	5C80.0	Approved	[818]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[315]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[259]

Drug(s) Affected By Cyclin-dependent kinase 4 (CDK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[819]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[820]
Selenium	DM25CGV	N. A.	N. A.	Approved	[280]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[821]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[282]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[822]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[283]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[518]

Drug(s) Affected By Bone morphogenetic protein 2 (BMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[823]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[824]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[825]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[289]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[247]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[307]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[673]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[259]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[826]

Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[727]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[294]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[827]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[616]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[713]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[828]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[742]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[284]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[829]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[261]

Drug(s) Affected By C-C motif chemokine 5 (CCL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[272]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[830]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[617]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[284]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[233]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[831]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[832]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[833]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[834]

Drug(s) Affected By Tissue factor (F3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[835]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[836]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[837]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[838]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[839]
Fructose	DM43AN2	Vomiting	MD90	Approved	[274]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[840]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[836]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[841]
Desloratadine	DM56YN7	Allergic rhinitis	CA08.0	Approved	[836]

Drug(s) Affected By HLA class I histocompatibility antigen, alpha chain E (HLA-E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[632]
Clindamycin	DM15HL8	Acne vulgaris	ED80	Approved	[632]
Selenium	DM25CGV	N. A.	N. A.	Approved	[159]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[632]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[233]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[344]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[257]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[632]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[236]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[254]

Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[842]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[294]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[614]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[616]
Selenium	DM25CGV	N. A.	N. A.	Approved	[773]
Pentosan Polysulfate	DM2HRKE	Interstitial cystitis	GC00.3	Approved	[843]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[791]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[543]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[844]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[641]

Drug(s) Affected By Indoleamine 2,3-dioxygenase 1 (IDO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-Tryptophan	DMIBH7M	Depression	6A70-6A7Z	Approved	[845]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[846]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[847]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[600]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[342]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[347]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[212]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[319]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[241]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[848]

Drug(s) Affected By Ras-related C3 botulinum toxin substrate 2 (RAC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[849]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[344]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[289]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[257]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[292]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[293]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[211]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[212]
Bortezomib	DMNO38U	Leukemia		Approved	[375]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[364]

Drug(s) Affected By CD44 antigen (CD44)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[207]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[250]
Selenium	DM25CGV	N. A.	N. A.	Approved	[850]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[851]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[233]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[852]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[289]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[853]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[854]

Drug(s) Affected By Histone H2AX (H2AX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[855]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[856]
Selenium	DM25CGV	N. A.	N. A.	Approved	[159]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[857]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[858]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[413]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[859]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[860]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[861]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]

Drug(s) Affected By Integrin beta-4 (ITGB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[271]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[862]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[224]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[282]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[862]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[221]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[297]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[236]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[264]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[863]

Drug(s) Affected By Cytotoxic T-lymphocyte protein 4 (CTLA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[864]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[865]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[866]
Rigosertib	DMOSTXF	Myelodysplastic syndrome	2A37	Phase 3	[867]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[868]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[869]

Drug(s) Affected By E-selectin (SELE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[870]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[871]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[154]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[872]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[208]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[873]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[660]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[874]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[875]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[876]

Drug(s) Affected By Arachidonate 5-lipoxygenase-activating protein (ALOX5AP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[285]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[233]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[841]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[257]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[264]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[258]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[375]
Warfarin	DMJYCVW	Atrial fibrillation	BC81.3	Approved	[877]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[376]

Drug(s) Affected By Integrin alpha-L (ITGAL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[224]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[284]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[878]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[879]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[236]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[878]
Bortezomib	DMNO38U	Leukemia		Approved	[375]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[213]

Drug(s) Affected By Interleukin-10 (IL10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[739]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[617]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[715]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[880]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[881]
Bisoprolol	DM3UZ95	Hypertension	BA00-BA04	Approved	[882]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[621]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[883]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[624]
Paroxetine	DM5PVQE	Anxiety disorder	6B00-6B0Z	Approved	[884]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 4 (TNFSF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[288]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[284]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[163]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[248]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[258]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[289]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[259]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[210]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[211]

Drug(s) Affected By Interleukin-4 receptor subunit alpha (IL4R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[250]
Selenium	DM25CGV	N. A.	N. A.	Approved	[159]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[282]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[404]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[164]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[254]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[885]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[247]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[258]

Drug(s) Affected By Cyclin-dependent kinase 2 (CDK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[255]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[278]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[378]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[886]
Selenium	DM25CGV	N. A.	N. A.	Approved	[280]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[362]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[887]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[543]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[283]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 5 (CD40)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[888]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[889]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[890]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[514]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[292]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[259]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[891]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[210]

Drug(s) Affected By CD27 antigen (CD27)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[518]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[210]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[892]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[211]
Bortezomib	DMNO38U	Leukemia		Approved	[893]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[894]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[868]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[315]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[895]

Drug(s) Affected By Serum paraoxonase/arylesterase 1 (PON1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[896]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[897]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[898]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[899]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[900]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[289]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[901]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[650]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[896]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[902]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[903]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[904]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[612]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[905]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[391]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[906]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[907]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[908]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[909]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[910]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[903]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[911]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[912]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[913]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[902]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[150]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[612]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[905]

Drug(s) Affected By Nitric oxide synthase 3 (NOS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[914]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[915]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[150]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[916]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[443]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[917]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[918]
Fructose	DM43AN2	Vomiting	MD90	Approved	[919]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[920]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[732]

Drug(s) Affected By M-phase inducer phosphatase 2 (CDC25B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[255]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[302]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[921]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[254]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[254]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[922]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[407]

Drug(s) Affected By HLA class I histocompatibility antigen, alpha chain F (HLA-F)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[632]
Selenium	DM25CGV	N. A.	N. A.	Approved	[159]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[256]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[923]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[344]
Repaglinide	DM5SXUV	Diabetic complication	5A2Y	Approved	[632]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[924]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[925]
Saquinavir	DMG814N	Human immunodeficiency virus infection	1C62	Approved	[632]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[347]

Drug(s) Affected By Type-1 angiotensin II receptor (AGTR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[926]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]
Fructose	DM43AN2	Vomiting	MD90	Approved	[274]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[163]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[263]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[357]
Estriol	DMOEM2I	Hormone deficiency	5A61.1	Approved	[927]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[182]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[927]

Drug(s) Affected By Sodium-dependent serotonin transporter (SLC6A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paroxetine	DM5PVQE	Anxiety disorder	6B00-6B0Z	Approved	[928]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[929]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[250]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[930]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[931]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]
Aripiprazole	DM3NUMH	Bipolar I disorder		Approved	[932]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[931]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[258]
Mepyramine	DMB4SFH	Allergic rhinitis	CA08.0	Approved	[933]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[934]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[935]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[695]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[229]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[936]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[937]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[938]
Selenium	DM25CGV	N. A.	N. A.	Approved	[159]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[169]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[337]

Drug(s) Affected By Heat shock 70 kDa protein 4 (HSPA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[939]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[758]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[249]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[284]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[339]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[325]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[600]

Drug(s) Affected By Nitric oxide synthase, inducible (NOS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[450]
Indomethacin	DMSC4A7	Bursitis		Approved	[226]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[940]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[941]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[282]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[656]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[339]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[415]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[262]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[942]

Drug(s) Affected By Myosin-10 (MYH10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[943]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[770]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[598]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[293]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[365]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[364]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[555]

Drug(s) Affected By Signal transducer and activator of transcription 3 (STAT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[150]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[485]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[944]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[945]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[946]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[443]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[947]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[948]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[261]

Drug(s) Affected By C-C chemokine receptor type 2 (CCR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[443]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[949]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[203]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[950]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[951]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[952]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[953]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[213]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[954]

Drug(s) Affected By T-lymphocyte activation antigen CD86 (CD86)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[955]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[617]
Kanamycin	DM2DMPO	Bacteremia	1A73	Approved	[956]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[284]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[956]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[285]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[956]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[247]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[514]

Drug(s) Affected By Signal transducer and activator of transcription 1-alpha/beta (STAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[249]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[957]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[243]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[227]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[595]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[958]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[243]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[306]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[863]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[600]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[959]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[960]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[961]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[692]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[962]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[963]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[964]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[965]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[966]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[467]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 4 (TNFRSF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[429]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[518]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[210]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[242]
Pimecrolimus	DMZLGRB	Atopic dermatitis	EA80	Approved	[628]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[868]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[315]

Drug(s) Affected By ATP-binding cassette sub-family G member 1 (ABCG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[161]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[244]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[191]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[297]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[326]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[326]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[326]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[369]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[925]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[750]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[334]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[361]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[967]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[968]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[969]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[330]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[970]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[971]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[325]

Drug(s) Affected By CX3C chemokine receptor 1 (CX3CR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[369]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[972]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[633]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[450]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[973]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[477]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[427]
GW-501516	DMPL2KM	Type-1 diabetes	5A10	Discontinued in Phase 4	[972]

Drug(s) Affected By Fatty acid synthase (FASN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[974]
Selenium	DM25CGV	N. A.	N. A.	Approved	[159]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[169]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[685]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[295]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[161]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[200]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[269]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[975]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[976]

Drug(s) Affected By Glycogen synthase kinase-3 beta (GSK3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[758]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[751]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[977]
Selenium	DM25CGV	N. A.	N. A.	Approved	[159]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[978]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[228]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[979]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[980]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[164]

Drug(s) Affected By Nuclear receptor ROR-gamma (RORC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[261]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[264]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[265]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[981]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[982]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[182]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[129]
Diphenylpyraline	DMW4X37	Allergic rhinitis	CA08.0	Approved	[983]

Drug(s) Affected By C-C chemokine receptor type 5 (CCR5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[984]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[985]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[986]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[987]
I3C	DMIGFOR	Breast cancer	2C60-2C65	Phase 3	[988]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[989]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[990]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[987]
EUGENOL	DM7US1H	Discovery agent	N.A.	Patented	[984]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[259]

Drug(s) Affected By Caspase-7 (CASP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[842]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[222]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[991]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[992]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[993]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[993]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[282]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[227]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[860]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[994]

Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[995]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[996]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[299]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[803]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[997]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[940]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[412]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[998]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[999]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[1000]

Drug(s) Affected By Cyclin-dependent kinase 4 inhibitor D (CDKN2D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[224]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[1001]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[608]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[768]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[254]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[254]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[258]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[1002]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[210]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[1001]

Drug(s) Affected By Ras-related C3 botulinum toxin substrate 3 (RAC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[163]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[307]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[212]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[865]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[364]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[407]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[450]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[477]
Isoflavone	DM7U58J	N. A.	N. A.	Phase 4	[1003]

Drug(s) Affected By Transforming protein RhoA (RHOA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[327]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[282]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[393]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[269]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[269]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[164]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[599]
Pamidronate	DMB4AVP	Bone Paget disease		Approved	[1004]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[1005]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]

Drug(s) Affected By Ras-related protein Rap-1A (RAP1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[1006]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[249]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[203]
Minodronate	DM50PMY	Osteoporosis	FB83.0	Approved	[1007]
Risedronate	DM5FLTY	Bone Paget disease		Approved	[1008]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[1009]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[258]
Pamidronate	DMB4AVP	Bone Paget disease		Approved	[1008]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[925]

Drug(s) Affected By Ras-related C3 botulinum toxin substrate 1 (RAC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[880]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[163]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[770]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[221]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[684]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[1010]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[293]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[1011]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[551]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[1012]

Drug(s) Affected By Rho GTPase-activating protein 4 (ARHGAP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[233]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[264]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[293]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[865]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[241]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[450]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[233]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[868]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[315]

Drug(s) Affected By Cyclin-dependent kinase 5 (CDK5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[359]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[250]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1013]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[344]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[575]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[292]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[293]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[1014]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[364]

Drug(s) Affected By Heat shock factor protein 1 (HSF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1015]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[1016]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[1016]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1017]
Ceftazidime	DM41GRA	Bacteremia	1A73	Approved	[1016]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Chlorpheniramine	DM5URA2	Allergic rhinitis	CA08.0	Approved	[1016]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[1016]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1016]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[1017]

Drug(s) Affected By E3 ubiquitin-protein ligase Mdm2 (MDM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Flucytosine	DM13VTW	Cryptococcal meningitis		Approved	[1018]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[1018]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1019]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[282]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[690]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[325]
Amifostine	DM5FL14	Mucositis	CA00	Approved	[1020]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[245]

Drug(s) Affected By CD83 antigen (CD83)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[543]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[270]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[1021]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[317]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[248]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[258]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[514]

Drug(s) Affected By Myosin light chain 5 (MYL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[258]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[600]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[376]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[364]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[321]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[315]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[1022]

Drug(s) Affected By Caldesmon (CALD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[159]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[344]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1023]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[259]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[293]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[300]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[212]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[1024]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[426]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[798]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[467]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[299]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[802]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[271]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[997]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[335]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[224]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[304]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[362]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[695]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1025]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[412]
Selenium	DM25CGV	N. A.	N. A.	Approved	[159]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1026]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[282]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[1018]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[228]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[339]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1027]

Drug(s) Affected By Sterol regulatory element-binding protein 2 (SREBF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[150]
Selenium	DM25CGV	N. A.	N. A.	Approved	[159]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[161]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[163]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[975]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[297]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[1028]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[1029]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[258]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[1029]

Drug(s) Affected By Forkhead box protein O1 (FOXO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[937]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[408]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[289]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1030]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[264]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[248]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[1031]

Drug(s) Affected By TNF receptor-associated factor 2 (TRAF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[228]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[161]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[518]
Ceritinib	DMB920Z	Non-small-cell lung cancer	2C25.Y	Approved	[1032]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[293]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[210]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[892]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[364]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[241]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[242]

Drug(s) Affected By Nuclear factor of activated T-cells, cytoplasmic 3 (NFATC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[284]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1033]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[1034]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[1035]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[364]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[241]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[1034]
Diphenylpyraline	DMW4X37	Allergic rhinitis	CA08.0	Approved	[983]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[321]

Drug(s) Affected By Myosin-binding protein H (MYBPH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[250]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[256]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[213]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[1036]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[1037]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[427]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 2 (BIRC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[1038]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[467]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[958]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[1039]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[853]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1040]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[1041]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[1042]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[1043]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]

Drug(s) Affected By Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[322]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1044]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[412]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[413]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[1045]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[415]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1046]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[325]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[416]

Drug(s) Affected By Bone morphogenetic protein receptor type-2 (BMPR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[244]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[245]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[1047]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[258]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[292]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[375]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[866]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[242]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[477]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[321]

Drug(s) Affected By Runt-related transcription factor 2 (RUNX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[636]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1048]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[824]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[233]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[670]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[245]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[1049]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[247]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[326]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[326]

Drug(s) Affected By Src substrate cortactin (CTTN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[344]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[326]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[326]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[258]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[326]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[293]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[300]

Drug(s) Affected By Squalene monooxygenase (SQLE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[170]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[116]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[405]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[247]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[248]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[925]
Racecadotril	DMFOTZ7	Diarrhea	ME05.1	Approved	[1050]

Drug(s) Affected By Caspase-8 (CASP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[1051]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[1052]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[1053]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[1054]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1055]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[412]
Selenium	DM25CGV	N. A.	N. A.	Approved	[159]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[999]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[284]

Drug(s) Affected By Interferon regulatory factor 4 (IRF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1056]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[357]
Bortezomib	DMNO38U	Leukemia		Approved	[1057]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[894]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[242]
Rigosertib	DMOSTXF	Myelodysplastic syndrome	2A37	Phase 3	[867]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[1058]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[1059]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[315]
T-5224	DMD3CUJ	Rheumatoid arthritis	FA20	Discontinued in Phase 2	[1057]

Drug(s) Affected By Tumor necrosis factor receptor type 1-associated DEATH domain protein (TRADD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[250]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[443]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[157]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[246]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[248]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[292]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[293]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[210]
Hesperidin	DMI5DW1	Vascular purpura	3B60	Approved	[1060]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[892]

Drug(s) Affected By Interleukin-17A (IL17A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[284]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[624]
Paroxetine	DM5PVQE	Anxiety disorder	6B00-6B0Z	Approved	[884]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1061]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[1062]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[603]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[1063]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[1064]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[1065]
Apilimod dimesylate	DM4N2O0	Non-hodgkin lymphoma	2B33.5	Phase 2	[1066]

Drug(s) Affected By Hypoxia-inducible factor 1-alpha (HIF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[1067]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1068]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[1069]
Triamterene	DM2HU9I	Congestive heart failure	BD10	Approved	[1069]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1070]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[305]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[767]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[170]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[1071]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]

Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[699]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[168]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[1072]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[1073]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[1074]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[1075]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[1076]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[1077]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[1078]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[726]

Drug(s) Affected By Interleukin-27 subunit alpha (IL27)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[427]
Nickel chloride	DMI12Y8	Discovery agent	N.A.	Investigative	[1079]

Drug(s) Affected By Scavenger receptor class B member 1 (SCARB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1080]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[1081]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[161]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[163]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[571]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[572]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[1028]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[354]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[1082]

Drug(s) Affected By Bcl2-associated agonist of cell death (BAD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[1083]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[467]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1084]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1085]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[161]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1086]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[518]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[680]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[246]

Drug(s) Affected By Rho guanine nucleotide exchange factor 2 (ARHGEF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[256]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[306]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[292]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[293]
Mebendazole	DMO14SG	Ascariasis	1F62	Approved	[1087]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[526]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[319]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[241]

Drug(s) Affected By Interleukin-17F (IL17F)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[990]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[315]

Drug(s) Affected By Sphingosine 1-phosphate receptor 3 (S1PR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[244]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[289]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[1088]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[382]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[384]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[241]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[1089]

Drug(s) Affected By Mitogen-activated protein kinase kinase kinase 14 (MAP3K14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[282]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[161]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[163]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[254]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[254]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[248]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[357]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[210]

Drug(s) Affected By Angiotensin-converting enzyme 2 (ACE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Captopril	DM458UM	Chronic heart failure	BD1Z	Approved	[1090]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[541]
Dantrolene	DM1D8XY	Hyperthermia	MG26	Approved	[541]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[541]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[541]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[541]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[541]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[541]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[541]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[541]

Drug(s) Affected By Forkhead box protein P3 (FOXP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[429]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[161]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1061]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[1091]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[865]
GSK618334	DMJPXZ4	Drug abuse	6C4G.1Z	Phase 1	[1092]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[315]
Dorsomorphin	DMKYXJW	Discovery agent	N.A.	Investigative	[1093]
Mepacrine	DMU8L7C	Discovery agent	N.A.	Investigative	[1094]

Drug(s) Affected By Interleukin-22 (IL22)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[516]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[982]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[315]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[429]
SGC-CBP30	DMTLRGZ	Discovery agent	N.A.	Investigative	[1095]

Drug(s) Affected By Interleukin-21 (IL21)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[265]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[990]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[446]
SGC-CBP30	DMTLRGZ	Discovery agent	N.A.	Investigative	[1095]

Drug(s) Affected By Podocin (NPHS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[245]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[364]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[315]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[1096]

Drug(s) Affected By Interleukin-23 subunit alpha (IL23A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[243]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[243]
Misoprostol	DMHVJFK	Medical abortion	JA00.1Z	Approved	[982]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[375]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[243]
Bortezomib	DMNO38U	Leukemia		Approved	[893]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[364]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[243]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[243]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[213]

Drug(s) Affected By Diablo IAP-binding mitochondrial protein (DIABLO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[507]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[302]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[412]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[767]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1097]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[1098]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[297]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[342]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[293]
Bendamustine hydrochloride	DMFH15Z	leukaemia	2A60-2B33	Approved	[994]

Drug(s) Affected By Dentin sialophosphoprotein (DSPP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[636]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1099]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[670]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[265]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[953]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[1100]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[1101]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[1102]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[869]
phenamil	DMJLUFM	Discovery agent	N.A.	Investigative	[1099]

Drug(s) Affected By 7-dehydrocholesterol reductase (DHCR7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[159]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[170]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[161]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[163]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[344]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[325]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[667]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[264]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[248]

Drug(s) Affected By CD2-associated protein (CD2AP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[408]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[293]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[426]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[182]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[342]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[1103]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[408]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[1104]

Drug(s) Affected By Cytochrome b-245 light chain (CYBA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1105]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[1106]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[233]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[1107]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1108]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[236]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[258]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[600]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]

Drug(s) Affected By 5-hydroxytryptamine receptor 7 (HTR7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[163]
Cyproheptadine	DM92AH3	Allergic rhinitis	CA08.0	Approved	[1109]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[1109]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[364]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[1110]
PD-0325901	DM27D4J	Breast cancer	2C60-2C65	Phase 2	[268]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[315]
SL65.0472	DMU5RKC	Cardiovascular disease	BA00-BE2Z	Discontinued in Phase 2	[1111]
SB-269970	DM8WTGA	Sleep-wake disorder	7A00-7B2Z	Terminated	[1109]
ICI-169369	DMQ0IOF	Anxiety disorder	6B00-6B0Z	Terminated	[1109]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 10 (TNFSF10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[1112]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[271]
Selenium	DM25CGV	N. A.	N. A.	Approved	[159]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[1113]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1114]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[543]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[339]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[958]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[805]

Drug(s) Affected By Leptin receptor (LEPR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[223]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1115]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[297]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[307]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[292]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[1116]
Ketamine	DMT5HA4	Anaesthesia	9A78.6	Approved	[1117]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[426]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[1118]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[450]

Drug(s) Affected By Liver carboxylesterase 1 (CES1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[1119]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[359]
Dextropropoxyphene	DM23HCX	Pain	MG30-MG3Z	Approved	[1120]
Selenium	DM25CGV	N. A.	N. A.	Approved	[159]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[1121]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[1122]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[1123]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[306]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[1124]

Drug(s) Affected By Small ribosomal subunit protein mS31 (MRPS31)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]
Haloperidol	DM96SE0	Delirium		Approved	[300]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[248]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[600]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[293]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[364]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[426]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[182]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[450]

Drug(s) Affected By Neuropilin-1 (NRP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[294]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[282]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[759]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[163]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[289]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[247]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[248]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[307]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[357]

Drug(s) Affected By Sterol regulatory element-binding protein cleavage-activating protein (SCAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[292]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[364]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[250]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[426]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[450]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[1125]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[315]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[408]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[1126]

Drug(s) Affected By Kinesin-like protein KIF6 (KIF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[1127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[292]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[426]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[242]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[477]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[1101]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[1128]
Rosuvastatin	DMMIQ7G	Arteriosclerosis	BD40	Approved	[1128]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[477]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[1129]

Drug(s) Affected By Collagen alpha-1(XIII) chain (COL13A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[208]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[247]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[212]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[382]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[555]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[319]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[1130]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[242]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[450]

Drug(s) Affected By 5-hydroxytryptamine receptor 3B (HTR3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[426]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[315]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[429]

Drug(s) Affected By ELL-associated factor 2 (EAF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[163]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[323]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[1131]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[247]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[292]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[323]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[211]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[865]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
HMG-CoA reductase (HMGCR)	TTPADOQ	HMDH_HUMAN	Inhibitor	[3]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Breast cancer resistance protein (ABCG2)	DTI7UX6	ABCG2_HUMAN	Substrate	[4]
Organic anion transporting polypeptide 1B1 (SLCO1B1)	DT3D8F0	SO1B1_HUMAN	Substrate	[5]
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[6]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4) Main DME	DE4LYSA	CP3A4_HUMAN	Substrate	[7]
Cytochrome P450 2D6 (CYP2D6)	DECB0K3	CP2D6_HUMAN	Substrate	[8]
UDP-glucuronosyltransferase 1A1 (UGT1A1)	DEYGVN4	UD11_HUMAN	Substrate	[9]
Mephenytoin 4-hydroxylase (CYP2C19)	DEGTFWK	CP2CJ_HUMAN	Substrate	[9]
Cytochrome P450 3A5 (CYP3A5) Main DME	DEIBDNY	CP3A5_HUMAN	Substrate	[10]
Cytochrome P450 2C8 (CYP2C8)	DES5XRU	CP2C8_HUMAN	Substrate	[11]
UDP-glucuronosyltransferase 2B7 (UGT2B7)	DEB3CV1	UD2B7_HUMAN	Substrate	[9]
UDP-glucuronosyltransferase 1A3 (UGT1A3)	DEF2WXN	UD13_HUMAN	Substrate	[9]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (PLCG2)	OTGVC9MY	PLCG2_HUMAN	Gene/Protein Processing	[12]
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)	OTRT3F3U	HMDH_HUMAN	Drug Response	[13]
5-hydroxytryptamine receptor 3B (HTR3B)	OTMGIYRE	5HT3B_HUMAN	Drug Response	[14]
5-hydroxytryptamine receptor 7 (HTR7)	OT44DEWB	5HT7R_HUMAN	Drug Response	[14]
7-dehydrocholesterol reductase (DHCR7)	OTLILBUI	DHCR7_HUMAN	Gene/Protein Processing	[15]
72 kDa type IV collagenase (MMP2)	OT5NIWA2	MMP2_HUMAN	Gene/Protein Processing	[16]
Advanced glycosylation end product-specific receptor (AGER)	OTPY0IH7	RAGE_HUMAN	Gene/Protein Processing	[17]
Aldehyde dehydrogenase, dimeric NADP-preferring (ALDH3A1)	OTAYZZE6	AL3A1_HUMAN	Gene/Protein Processing	[12]
Aldo-keto reductase family 1 member C1 (AKR1C1)	OTQKR4CM	AK1C1_HUMAN	Gene/Protein Processing	[12]
Aldo-keto reductase family 1 member C3 (AKR1C3)	OTU2SXBA	AK1C3_HUMAN	Gene/Protein Processing	[18]

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