Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM30SGU)

• Drug Name: Simvastatin Drug Info
• Synonyms: Cholestat; Coledis; Colemin; Corolin; Denan; Labistatin; Lipex; Lipovas; Lodales; Medipo; Nivelipol; Pantok; Rendapid; Simovil; Simvastatina; Simvastatine; Simvastatinum; Sinvacor; Sivastin; Synvinolin; Vasotenal; Zocor; Zocord; Simvast CR; Simvastatina [Spanish]; Simvastatine [French]; Simvastatinum [Latin]; MK 0733; MK 733; MK733; TNP00259; DRG-0320; KS-1113; L 644128-000U; MK-0733; MK-733; Simcard (TN); Simlup (TN); Simvacor (TN); Simvastatin & Primycin; Simvastatin, Compactin; Zocor (TN); Simvastatin [USAN:INN:BAN]; Simvastatin (JAN/USP/INN); Zocor, Simlup, Simcard, Simvacor, Simvoget, Zorced, Simvastatin; [(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoate; Butanoic acid, 2,2-dimethyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester; Butanoic acid, 2,2-dimethyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-((2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester; Butanoic acid, 2,2-dimethyl-, (1S,3R,7S,8S,*aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-((2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester; (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate; Butanoic acid, 2,2-dimethyl-,1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)-ethyl]-1-naphthalenyl ester, [1S-[1 alpha,3 alpha,7 beta,8 beta(2S*,4S*),-8a beta; 2,2-Dimethylbutanoic acid (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester; 2,2-Dimethylbutyric acid, 8-ester with (4R,6R)-6-(2-((1S,2S,6R,8S,8aR)-1,2,6,7,8,8a-hexahydro-8-hydroxy-2,6-dimethyl-1-naphthyl)ethyl)tetrahydro-4-hydroxy-2H-pyran-2-one

Indication

Disease Entry	ICD 11	Status	REF
Arteriosclerosis	BD40	Approved	[1]
Atherosclerosis	BD40	Approved	[1]
Coronary heart disease	BA80.Z	Approved	[1]
Cystic fibrosis	CA25	Approved	[1]
Depression	6A70-6A7Z	Approved	[1]
Hypercholesterolaemia	5C80.0	Approved	[2]
Hyperlipidemia	5C80.Z	Approved	[1]
Hyperlipidemia, familial combined, LPL related		Approved	[1]
Hypertriglyceridemia	5C80.1	Approved	[1]
Pneumonia	CA40	Approved	[1]
Primary hypercholesterolemia	5C80.00	Approved	[1]
Prostate carcinoma		Approved	[1]
Rhinitis	FA20	Approved	[1]
Type-1/2 diabetes	5A10-5A11	Approved	[1]
Stroke	8B20	Investigative	[1]

• Therapeutic Class: Anticholesteremic Agents
• Cross-matching ID:
  PubChem CID: 54454
  ChEBI ID: CHEMBL1064
  CAS Number: CAS 79902-63-9
  TTD Drug ID: DM30SGU
  VARIDT Drug ID: DR00435
  INTEDE Drug ID: DR1485
  ACDINA Drug ID: D00625

Molecule-Related Drug Atlas

Drug(s) Targeting HMG-CoA reductase (HMGCR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[18]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[3]
Cerivastatin	DMXCM7H	Hyperlipidaemia	5C80	Approved	[19]
PITAVASTATIN CALCIUM	DM1UJO0	Dyslipidemia	5C80-5C81	Approved	[20]
Rosuvastatin	DMMIQ7G	Arteriosclerosis	BD40	Approved	[21]
Fluvastatin	DM4MDJY	Arteriosclerosis	BD40	Approved	[3]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[22]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[23]
Teriflunomide	DMQ2FKJ	Hyperlipidaemia	5C80	Approved	[22]
TOCOTRIENOL	DM1UE67	Hyperlipidaemia	5C80	Approved	[24]

Drug(s) Transported By P-glycoprotein 1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[4]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[25]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[6]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[26]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[6]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[6]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[27]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[6]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[28]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[29]

Drug(s) Transported By Breast cancer resistance protein (ABCG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[30]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[31]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[32]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[33]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[34]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[35]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[36]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[35]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[37]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[38]

Drug(s) Transported By Organic anion transporting polypeptide 1B1 (SLCO1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[39]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[40]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[41]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[42]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[41]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[43]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[44]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[45]
Cerivastatin	DMXCM7H	Hyperlipidaemia	5C80	Approved	[46]
PITAVASTATIN CALCIUM	DM1UJO0	Dyslipidemia	5C80-5C81	Approved	[43]

Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[47]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[48]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[49]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[50]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[51]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[52]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[53]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[54]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[48]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[55]

Drug(s) Metabolized By UDP-glucuronosyltransferase 1A1 (UGT1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[56]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[57]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[58]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[59]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[62]
Metronidazole	DMTIVEN	Abscess		Approved	[63]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[64]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[65]

Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[66]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[67]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[68]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[51]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[55]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[69]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[70]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[71]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[72]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[73]

Drug(s) Metabolized By Cytochrome P450 3A5 (CYP3A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[74]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[75]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[76]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[77]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[78]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[79]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[80]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[81]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[82]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[77]

Drug(s) Metabolized By Cytochrome P450 2C8 (CYP2C8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[83]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[84]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[84]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[85]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[86]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[87]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[88]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[84]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[89]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[90]

Drug(s) Metabolized By Mephenytoin 4-hydroxylase (CYP2C19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[91]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[92]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[93]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[94]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[85]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[95]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[97]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[98]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[90]

Drug(s) Metabolized By UDP-glucuronosyltransferase 2B7 (UGT2B7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[99]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[100]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[101]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[89]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[55]
PITAVASTATIN CALCIUM	DM1UJO0	Dyslipidemia	5C80-5C81	Approved	[102]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[103]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[104]
Losartan	DM72JXH	Diabetic kidney disease	GB61.Z	Approved	[55]

Drug(s) Metabolized By UDP-glucuronosyltransferase 1A3 (UGT1A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[55]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[106]
Cerivastatin	DMXCM7H	Hyperlipidaemia	5C80	Approved	[107]
PITAVASTATIN CALCIUM	DM1UJO0	Dyslipidemia	5C80-5C81	Approved	[102]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[103]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[108]
Losartan	DM72JXH	Diabetic kidney disease	GB61.Z	Approved	[55]
Naproxen	DMZ5RGV	Bursitis		Approved	[109]

Drug(s) Affected By Solute carrier organic anion transporter family member 1B1 (SLCO1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Enalapril	DMNFUZR	Congestive heart failure	BD10	Approved	[110]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[111]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[112]
Repaglinide	DM5SXUV	Diabetic complication	5A2Y	Approved	[113]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[114]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[115]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[115]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[116]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[117]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[118]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[119]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[120]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[121]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[122]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[123]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[124]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[125]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[126]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[127]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[125]

Drug(s) Affected By Stromelysin-1 (MMP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluvastatin	DM4MDJY	Arteriosclerosis	BD40	Approved	[128]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[128]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[128]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[129]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[130]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[131]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[132]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[133]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[134]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[136]
Vidarabine	DM0N85H	Hepatosplenic T-cell lymphoma		Approved	[136]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[137]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[138]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[139]
Etidronic acid	DM1XHYJ	Bone Paget disease		Approved	[136]
Tiaprofenic acid	DM23D7J	Osteoarthritis	FA00-FA05	Approved	[136]
Bromperidol	DM24XYQ	Schizophrenia	6A20	Approved	[136]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[140]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[141]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 3 (NR1I3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[142]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[143]
Artemether	DM48QOT	Malaria	1F40-1F45	Approved	[144]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[145]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[146]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[147]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[148]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[149]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[150]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[148]

Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[151]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[152]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[153]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[154]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[155]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[156]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[157]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[158]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[159]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[160]

Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[129]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[161]
Selenium	DM25CGV	N. A.	N. A.	Approved	[162]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[163]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[164]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[165]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[166]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[167]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[168]
Desloratadine	DM56YN7	Allergic rhinitis	CA08.0	Approved	[169]

Drug(s) Affected By CCN family member 1 (CCN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[170]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[171]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[165]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[172]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[171]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[174]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[175]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[177]

Drug(s) Affected By Cell division control protein 45 homolog (CDC45)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[178]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[159]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[172]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[179]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[180]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[181]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[181]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[182]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[183]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[184]

Drug(s) Affected By Integrin beta-like protein 1 (ITGBL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[185]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[186]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[187]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[188]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[186]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[189]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[190]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[191]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[192]
PD-0325901	DM27D4J	Breast cancer	2C60-2C65	Phase 2	[193]

Drug(s) Affected By Protein S100-A8 (S100A8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[194]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[194]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[195]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[195]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[180]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[196]
Halothane	DM80OZ5	Anaesthesia	9A78.6	Approved	[194]
Dicloxacillin	DM8EU0Z	Bacterial infection	1A00-1C4Z	Approved	[194]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[150]

Drug(s) Affected By Protein S100-A9 (S100A9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[194]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[197]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[195]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[195]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[198]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[199]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[196]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[200]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[150]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[201]

Drug(s) Affected By Protein S100-A6 (S100A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[202]
Selenium	DM25CGV	N. A.	N. A.	Approved	[162]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[165]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[199]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[203]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[204]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[205]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[182]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[206]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[207]

Drug(s) Affected By Stromelysin-2 (MMP10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[150]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[208]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[171]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[165]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[195]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[171]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[195]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[209]
Haloperidol	DM96SE0	Delirium		Approved	[210]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[150]

Drug(s) Affected By Annexin A3 (ANXA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[165]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[186]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[203]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[211]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[181]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[186]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[181]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[177]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[212]

Drug(s) Affected By Keratin, type I cytoskeletal 13 (KRT13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[213]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[204]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[211]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[215]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[216]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[217]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[218]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[219]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[220]

Drug(s) Affected By 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (PLCG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[222]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[223]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[206]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[190]
Ibrutinib	DMHZCPO	Mantle cell lymphoma	2A85.5	Approved	[224]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[225]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[225]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[226]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[227]

Drug(s) Affected By Keratin, type I cytoskeletal 15 (KRT15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[228]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[165]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[195]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[195]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[189]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[229]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[182]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[201]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[229]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[229]

Drug(s) Affected By Calmodulin-like protein 3 (CALML3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[230]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[211]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[189]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[201]
Seocalcitol	DMKL9QO	Rickets	5B57	Phase 3	[231]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[220]

Drug(s) Affected By Tyrosine-protein kinase receptor UFO (AXL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[162]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[232]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[165]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[232]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[233]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[177]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[229]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[229]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[229]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[234]

Drug(s) Affected By Aldehyde dehydrogenase, dimeric NADP-preferring (ALDH3A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[235]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[236]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[237]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[211]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[177]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[150]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[238]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[239]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[240]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[241]

Drug(s) Affected By DNA replication licensing factor MCM4 (MCM4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[178]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[155]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[159]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[172]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[174]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[181]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[181]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[242]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[243]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[244]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[245]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[246]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[247]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[248]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[170]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[249]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[250]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[251]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[252]

Drug(s) Affected By Macrophage metalloelastase (MMP12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[171]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[165]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[171]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[180]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[181]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[181]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[150]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[171]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[253]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[171]

Drug(s) Affected By Replication factor C subunit 5 (RFC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[178]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[172]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[167]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[150]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[184]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[207]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[210]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[254]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[255]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[256]

Drug(s) Affected By Regulator of G-protein signaling 2 (RGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[228]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[197]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[165]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[257]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[258]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[209]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[259]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[260]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[212]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[261]

Drug(s) Affected By Collagenase 3 (MMP13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[262]
Clindamycin	DM15HL8	Acne vulgaris	ED80	Approved	[263]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[262]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[264]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[265]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[188]
Doxycycline	DM7ICNU	Acne vulgaris	ED80	Approved	[263]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[260]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[231]
Prinomastat	DM9HOKG	Lung cancer	2C25.0	Approved	[266]

Drug(s) Affected By DNA primase small subunit (PRIM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[178]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[185]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[172]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[181]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[181]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[150]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[201]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[183]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[184]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1C (CDKN1C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[228]
Selenium	DM25CGV	N. A.	N. A.	Approved	[162]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[267]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[195]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[195]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[211]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[212]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[201]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[268]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[269]

Drug(s) Affected By Transcription factor E2F1 (E2F1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[270]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[208]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[271]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[272]
Selenium	DM25CGV	N. A.	N. A.	Approved	[162]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[252]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[273]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[165]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[172]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[195]

Drug(s) Affected By Collagen alpha-1(VII) chain (COL7A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[274]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[165]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[172]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[275]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[276]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[150]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[206]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[277]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[278]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[253]

Drug(s) Affected By Aldo-keto reductase family 1 member C1 (AKR1C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[279]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[280]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[281]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[282]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[280]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[280]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[283]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[282]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[280]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[284]

Drug(s) Affected By BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[155]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[165]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[285]
Quinolones	DM5GVHU	Bacterial infection	1A00-1C4Z	Approved	[286]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[287]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[175]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[259]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[229]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[165]

Drug(s) Affected By Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[178]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[288]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[289]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[172]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[290]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[181]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[181]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[150]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[207]

Drug(s) Affected By Centromere protein R (ITGB3BP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[165]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[172]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[291]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[182]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[201]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[254]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[239]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[253]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[292]

Drug(s) Affected By Rho GTPase-activating protein 29 (ARHGAP29)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[228]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[293]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[186]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[177]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[212]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[201]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[207]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[294]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[253]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[295]

Drug(s) Affected By Interleukin-20 receptor subunit beta (IL20RB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[228]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[165]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[203]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[188]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[150]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[296]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[184]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[278]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[253]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[225]

Drug(s) Affected By Bcl-2-binding component 3, isoforms 3/4 (BBC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[228]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[297]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[298]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[299]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[300]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[301]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[302]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[303]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[304]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[305]

Drug(s) Affected By Krueppel-like factor 6 (KLF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[208]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[306]
Selenium	DM25CGV	N. A.	N. A.	Approved	[162]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[252]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[165]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[172]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[203]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[177]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[150]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[206]

Drug(s) Affected By Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (PKMYT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[178]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[165]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[172]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[174]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[181]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[181]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[201]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[307]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[253]

Drug(s) Affected By Cell division control protein 6 homolog (CDC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[178]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[252]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[289]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[172]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[167]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[308]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[181]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[181]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[150]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[206]

Drug(s) Affected By Spondin-2 (SPON2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[309]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[180]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[150]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[201]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[310]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[311]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[312]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[313]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[227]

Drug(s) Affected By Rac GTPase-activating protein 1 (RACGAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[314]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[291]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[181]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[181]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[177]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[150]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[201]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[184]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[207]

Drug(s) Affected By DNA replication factor Cdt1 (CDT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[208]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[165]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[172]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[181]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[181]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[150]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[201]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[183]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[184]

Drug(s) Affected By Matrix metalloproteinase-28 (MMP28)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[257]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[198]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[315]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[240]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[316]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[317]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[312]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[318]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[319]

Drug(s) Affected By Alpha-catulin (CTNNAL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[320]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[167]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[275]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[209]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[150]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[201]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[183]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[321]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[239]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[253]

Drug(s) Affected By Protein DBF4 homolog A (DBF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[178]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[202]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[165]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[181]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[181]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[150]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[206]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[322]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[253]

Drug(s) Affected By Krueppel-like factor 2 (KLF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[197]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[188]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[211]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[196]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[150]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[323]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[253]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[225]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[240]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[310]

Drug(s) Affected By NPC1-like intracellular cholesterol transporter 1 (NPC1L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[324]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[325]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[238]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[326]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[310]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[327]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[328]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[293]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[329]

Drug(s) Affected By Signal transducer CD24 (CD24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[314]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[324]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[203]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[330]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[181]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[181]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[203]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[239]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[331]

Drug(s) Affected By Aldo-keto reductase family 1 member C3 (AKR1C3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[332]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[280]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[281]
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[333]
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[333]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[280]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[280]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[334]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[257]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[283]

Drug(s) Affected By Killer cell immunoglobulin-like receptor 2DS2 (KIR2DS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[324]

Drug(s) Affected By Killer cell lectin-like receptor subfamily F member 1 (KLRF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[335]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[220]
CHOLINE	DM5D9YK	Insomnia	7A00-7A0Z	Investigative	[336]

Drug(s) Affected By Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHUK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[337]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[165]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[338]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[339]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[209]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[340]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[182]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[341]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[207]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[342]

Drug(s) Affected By ATP-binding cassette sub-family C member 3 (ABCC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[343]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[344]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[345]
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[346]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[347]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[348]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[228]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[349]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[350]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[351]

Drug(s) Affected By Bile salt export pump (ABCB11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[352]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[353]
Glipizide	DMZA5PQ	Diabetic complication	5A2Y	Approved	[353]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[112]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[352]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[353]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[354]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[352]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[355]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[352]

Drug(s) Affected By Farnesyl pyrophosphate synthase (FDPS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[165]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[160]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[230]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[290]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[150]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[201]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[207]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[356]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[253]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[357]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[129]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[358]
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[359]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[360]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[361]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[289]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[362]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[203]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[363]

Drug(s) Affected By Dynamin-1-like protein (DNM1L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[364]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[365]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[182]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[366]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[207]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[367]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[368]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[364]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[369]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[370]

Drug(s) Affected By Suppressor of cytokine signaling 7 (SOCS7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[182]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[206]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[371]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[372]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[332]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[371]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[227]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[220]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[373]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[288]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[247]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[374]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[297]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[249]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[298]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[375]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[376]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[377]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[378]

Drug(s) Affected By CASP8 and FADD-like apoptosis regulator (CFLAR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[379]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[380]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[381]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[382]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[159]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[377]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[383]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[384]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[385]

Drug(s) Affected By Serine protease HTRA2, mitochondrial (HTRA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[386]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[275]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[181]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[181]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[206]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[207]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[387]
Bortezomib	DMNO38U	Leukemia		Approved	[388]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[389]

Drug(s) Affected By Alpha-actinin-4 (ACTN4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[162]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[150]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[201]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[207]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[390]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[239]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[216]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[332]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[162]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[391]

Drug(s) Affected By E3 ubiquitin-protein ligase MARCHF6 (MARCHF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[162]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[206]
Betaine	DMGRZW2	Cystitis	GC00	Approved	[392]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[393]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[394]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[317]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[395]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[162]
ANW-32821	DMMJOZD	N. A.	N. A.	Phase 2	[392]
CB-5083	DM12GN7	Multiple myeloma	2A83	Phase 1	[392]

Drug(s) Affected By Nephrin (NPHS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[396]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[201]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[397]
Bezafibrate	DMZDCS0	Hypercholesterolaemia	5C80.0	Approved	[398]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[312]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[219]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[220]
PIRINIXIC ACID	DM82Y75	Pulmonary fibrosis	CB03.4	Preclinical	[398]
Puromycin	DMDKLB5	N. A.	N. A.	Preclinical	[399]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[400]

Drug(s) Affected By Apolipoprotein M (APOM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[228]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[165]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[150]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[296]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[253]
Chenodiol	DMQ8JIK	Cholelithiasis	DC11	Approved	[401]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[162]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[318]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[402]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[403]

Drug(s) Affected By Phospholipid-transporting ATPase ABCA1 (ABCA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[404]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[165]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[405]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[160]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[406]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[407]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[408]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[409]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[410]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[411]

Drug(s) Affected By Prothrombin (F2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[412]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[197]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[413]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[414]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[415]
Phytonadione	DM8HDOL	Bleeding disorder	GA20-GA21	Approved	[416]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[150]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[417]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[418]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[315]

Drug(s) Affected By Protein c-Fos (FOS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[174]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[245]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[419]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[153]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[419]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[348]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[155]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[420]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[421]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[422]

Drug(s) Affected By Interleukin-2 receptor subunit alpha (IL2RA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[324]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[423]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[424]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[425]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[426]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[427]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[428]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[201]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[190]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[429]

Drug(s) Affected By HLA class II histocompatibility antigen, DQ beta 1 chain (HLA-DQB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[430]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[431]
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[431]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[432]
Allopurinol	DMLPAOB	Gout	FA25	Approved	[433]
Ticlopidine	DMO946V	Acute coronary syndrome	BA41	Approved	[434]
Selenium	DM25CGV	N. A.	N. A.	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[309]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[230]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[431]

Drug(s) Affected By Collagen alpha-1(I) chain (COL1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[128]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[435]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[274]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[379]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[436]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[437]
Ceruletide	DM2WE5K	Caerulein stimulated gastric and pancreatic secretion	5A4Y	Approved	[438]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[439]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[440]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[160]

Drug(s) Affected By Collagen alpha-1(III) chain (COL3A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[435]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[441]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[442]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[443]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[444]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[445]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[189]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[446]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[447]

Drug(s) Affected By C-reactive protein (CRP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lidocaine	DML4ZOT	Anaesthesia	9A78.6	Approved	[128]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[448]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[449]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[160]
Acalabrutinib	DM7GCVW	leukaemia	2A60-2B33	Approved	[450]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[451]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[452]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[453]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[259]
Milrinone	DM8TUPF	Congestive heart failure	BD10	Approved	[454]

Drug(s) Affected By Osteocalcin (BGLAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[455]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[456]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[436]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[165]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[457]
Pamidronate	DMB4AVP	Bone Paget disease		Approved	[458]
Falecalcitrol	DMBI9ZJ	Hyperparathyroidism	5A51	Approved	[459]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[460]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[234]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[461]

Drug(s) Affected By Interstitial collagenase (MMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[178]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[462]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[463]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[131]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[464]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[465]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[134]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[466]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[198]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[211]

Drug(s) Affected By RAF proto-oncogene serine/threonine-protein kinase (RAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[467]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[443]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[468]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[174]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[469]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[470]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[471]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[472]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[260]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[473]

Drug(s) Affected By Amyloid-beta precursor protein (APP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[155]
Selenium	DM25CGV	N. A.	N. A.	Approved	[162]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[197]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[172]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[474]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[475]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[476]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[174]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[477]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[478]

Drug(s) Affected By Plasminogen activator inhibitor 1 (SERPINE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[479]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[130]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[480]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[481]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[482]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[160]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[483]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[146]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[363]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[209]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[484]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[485]
Fructose	DM43AN2	Vomiting	MD90	Approved	[128]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[486]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[487]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[153]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[246]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[202]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[488]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[489]

Drug(s) Affected By Retinoblastoma-associated protein (RB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[490]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[491]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[492]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[248]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[155]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[493]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[273]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[494]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[267]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[495]

Drug(s) Affected By Calpain-1 catalytic subunit (CAPN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[496]
Selenium	DM25CGV	N. A.	N. A.	Approved	[162]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[497]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[498]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[499]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[500]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[150]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[501]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[201]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[207]

Drug(s) Affected By Heat shock protein HSP 90-alpha (HSP90AA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[502]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[129]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[358]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[503]
Selenium	DM25CGV	N. A.	N. A.	Approved	[162]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[504]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[505]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[150]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[201]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[207]

Drug(s) Affected By Rho-related GTP-binding protein RhoC (RHOC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[165]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[257]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[506]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[507]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[196]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[182]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[508]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[243]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[207]
Terbinafine	DMI6HUW	Fungal infection	1F29-1F2F	Approved	[509]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[208]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[510]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[511]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[297]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[512]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[251]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[512]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[513]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[514]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[515]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[516]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[517]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[518]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[519]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[487]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[520]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[521]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[522]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[523]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[521]

Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[524]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[358]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[525]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[526]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[527]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[528]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[529]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[197]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[530]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[186]

Drug(s) Affected By C-C motif chemokine 5 (CCL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[246]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[531]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[532]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[197]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[172]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[167]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[533]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[534]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[535]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[536]

Drug(s) Affected By HLA class I histocompatibility antigen, alpha chain E (HLA-E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[431]
Clindamycin	DM15HL8	Acne vulgaris	ED80	Approved	[431]
Selenium	DM25CGV	N. A.	N. A.	Approved	[162]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[431]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[167]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[230]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[180]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[431]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[259]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[181]

Drug(s) Affected By Ras-related C3 botulinum toxin substrate 2 (RAC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[537]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[230]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[203]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[180]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[206]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[207]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[538]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[239]
Bortezomib	DMNO38U	Leukemia		Approved	[268]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[253]

Drug(s) Affected By CD44 antigen (CD44)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[129]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[539]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[228]
Selenium	DM25CGV	N. A.	N. A.	Approved	[540]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[541]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[167]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[542]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[203]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[543]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[544]

Drug(s) Affected By Histone H2AX (H2AX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[545]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[546]
Selenium	DM25CGV	N. A.	N. A.	Approved	[162]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[547]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[548]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[299]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[549]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[550]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[551]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[172]

Drug(s) Affected By Integrin beta-4 (ITGB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[379]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[552]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[155]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[464]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[552]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[152]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[209]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[259]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[553]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 4 (TNFSF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[202]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[197]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[165]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[257]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[177]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[182]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[203]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[183]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[554]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[538]

Drug(s) Affected By Interleukin-4 receptor subunit alpha (IL4R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[228]
Selenium	DM25CGV	N. A.	N. A.	Approved	[162]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[464]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[289]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[275]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[181]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[555]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[182]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 5 (CD40)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[129]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[556]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[557]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[558]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[428]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[206]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[183]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[559]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[554]

Drug(s) Affected By CD27 antigen (CD27)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[363]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[201]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[554]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[560]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[538]
Bortezomib	DMNO38U	Leukemia		Approved	[561]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[562]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[563]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[220]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[564]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[565]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[566]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[567]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[568]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[569]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[570]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[571]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[572]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[573]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[574]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[575]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[566]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[576]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[577]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[578]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[565]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[128]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[129]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[568]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[569]

Drug(s) Affected By M-phase inducer phosphatase 2 (CDC25B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[178]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[579]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[580]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[181]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[181]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[150]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[201]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[581]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[292]

Drug(s) Affected By HLA class I histocompatibility antigen, alpha chain F (HLA-F)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[431]
Selenium	DM25CGV	N. A.	N. A.	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[179]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[582]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[230]
Repaglinide	DM5SXUV	Diabetic complication	5A2Y	Approved	[431]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[583]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[584]
Saquinavir	DMG814N	Human immunodeficiency virus infection	1C62	Approved	[431]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[326]

Drug(s) Affected By Sodium-dependent serotonin transporter (SLC6A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paroxetine	DM5PVQE	Anxiety disorder	6B00-6B0Z	Approved	[585]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[586]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[228]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[587]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[588]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[165]
Aripiprazole	DM3NUMH	Bipolar I disorder		Approved	[589]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[588]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[182]
Mepyramine	DMB4SFH	Allergic rhinitis	CA08.0	Approved	[590]

Drug(s) Affected By Heat shock 70 kDa protein 4 (HSPA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[591]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[496]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[314]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[197]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[165]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[592]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[285]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[150]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[593]

Drug(s) Affected By Myosin-10 (MYH10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[594]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[507]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[595]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[150]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[201]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[207]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[254]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[253]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[394]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 4 (TNFRSF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[320]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[363]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[201]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[554]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[596]
Pimecrolimus	DMZLGRB	Atopic dermatitis	EA80	Approved	[426]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[563]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[220]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[491]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[597]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[250]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[598]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[599]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[600]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[601]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[602]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[603]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[285]

Drug(s) Affected By Cyclin-dependent kinase 4 inhibitor D (CDKN2D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[155]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[604]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[605]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[606]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[181]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[181]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[182]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[607]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[554]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[604]

Drug(s) Affected By Ras-related C3 botulinum toxin substrate 3 (RAC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[257]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[212]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[201]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[239]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[608]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[253]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[292]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[332]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[395]
Isoflavone	DM7U58J	N. A.	N. A.	Phase 4	[609]

Drug(s) Affected By Ras-related protein Rap-1A (RAP1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[610]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[314]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[146]
Minodronate	DM50PMY	Osteoporosis	FB83.0	Approved	[611]
Risedronate	DM5FLTY	Bone Paget disease		Approved	[612]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[613]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[182]
Pamidronate	DMB4AVP	Bone Paget disease		Approved	[612]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[584]

Drug(s) Affected By Rho GTPase-activating protein 4 (ARHGAP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[167]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[189]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[201]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[207]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[608]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[240]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[332]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[167]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[563]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[220]

Drug(s) Affected By Heat shock factor protein 1 (HSF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[614]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[615]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[615]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[616]
Ceftazidime	DM41GRA	Bacteremia	1A73	Approved	[615]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Chlorpheniramine	DM5URA2	Allergic rhinitis	CA08.0	Approved	[615]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[615]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[615]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[616]

Drug(s) Affected By CD83 antigen (CD83)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[381]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[165]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[172]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[196]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[617]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[223]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[177]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[182]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[428]

Drug(s) Affected By Myosin light chain 5 (MYL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[165]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[182]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[593]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[201]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[269]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[253]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[227]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[220]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[618]

Drug(s) Affected By Caldesmon (CALD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[162]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[230]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[619]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[201]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[183]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[207]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[210]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[239]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[620]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[317]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[621]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[622]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[297]
Selenium	DM25CGV	N. A.	N. A.	Approved	[162]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[623]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[464]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[624]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[159]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[592]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[625]

Drug(s) Affected By Sterol regulatory element-binding protein 2 (SREBF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[128]
Selenium	DM25CGV	N. A.	N. A.	Approved	[162]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[160]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[257]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[626]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[209]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[627]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[628]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[182]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[628]

Drug(s) Affected By TNF receptor-associated factor 2 (TRAF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[159]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[160]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[363]
Ceritinib	DMB920Z	Non-small-cell lung cancer	2C25.Y	Approved	[629]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[207]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[554]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[560]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[253]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[240]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[596]

Drug(s) Affected By Nuclear factor of activated T-cells, cytoplasmic 3 (NFATC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[197]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[630]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[631]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[201]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[632]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[253]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[240]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[631]
Diphenylpyraline	DMW4X37	Allergic rhinitis	CA08.0	Approved	[633]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[227]

Drug(s) Affected By Myosin-binding protein H (MYBPH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[228]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[179]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[201]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[357]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[634]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[635]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[318]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 2 (BIRC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[636]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[637]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[638]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[639]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[543]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[640]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[641]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[642]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[643]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[150]

Drug(s) Affected By Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[644]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[645]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[297]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[299]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[165]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[646]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[301]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[647]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[285]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[302]

Drug(s) Affected By Src substrate cortactin (CTTN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[165]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[230]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[229]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[229]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[182]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[201]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[229]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[207]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[210]

Drug(s) Affected By Interferon regulatory factor 4 (IRF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[648]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[243]
Bortezomib	DMNO38U	Leukemia		Approved	[649]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[562]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[596]
Rigosertib	DMOSTXF	Myelodysplastic syndrome	2A37	Phase 3	[650]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[651]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[652]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[220]
T-5224	DMD3CUJ	Rheumatoid arthritis	FA20	Discontinued in Phase 2	[649]

Drug(s) Affected By Tumor necrosis factor receptor type 1-associated DEATH domain protein (TRADD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[228]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[324]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[175]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[177]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[206]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[207]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[554]
Hesperidin	DMI5DW1	Vascular purpura	3B60	Approved	[653]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[560]

Drug(s) Affected By Interleukin-27 subunit alpha (IL27)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[201]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[318]
Nickel chloride	DMI12Y8	Discovery agent	N.A.	Investigative	[654]

Drug(s) Affected By Bcl2-associated agonist of cell death (BAD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[655]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[637]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[129]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[656]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[657]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[160]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[658]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[363]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[469]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[175]

Drug(s) Affected By Rho guanine nucleotide exchange factor 2 (ARHGEF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[172]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[179]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[211]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[150]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[206]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[207]
Mebendazole	DMO14SG	Ascariasis	1F62	Approved	[659]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[371]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[225]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[240]

Drug(s) Affected By Interleukin-17F (IL17F)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[660]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[220]

Drug(s) Affected By Mitogen-activated protein kinase kinase kinase 14 (MAP3K14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[464]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[165]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[160]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[257]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[181]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[181]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[177]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[150]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[243]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[554]

Drug(s) Affected By Forkhead box protein P3 (FOXP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[320]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[160]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[661]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[662]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[201]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[608]
GSK618334	DMJPXZ4	Drug abuse	6C4G.1Z	Phase 1	[663]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[220]
Dorsomorphin	DMKYXJW	Discovery agent	N.A.	Investigative	[664]
Mepacrine	DMU8L7C	Discovery agent	N.A.	Investigative	[665]

Drug(s) Affected By Podocin (NPHS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[174]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[253]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[220]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[666]

Drug(s) Affected By Interleukin-23 subunit alpha (IL23A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[171]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[171]
Misoprostol	DMHVJFK	Medical abortion	JA00.1Z	Approved	[667]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[268]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[171]
Bortezomib	DMNO38U	Leukemia		Approved	[561]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[253]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[171]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[171]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[357]

Drug(s) Affected By Diablo IAP-binding mitochondrial protein (DIABLO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[386]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[579]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[297]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[668]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[669]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[670]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[209]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[315]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[207]
Bendamustine hydrochloride	DMFH15Z	leukaemia	2A60-2B33	Approved	[671]

Drug(s) Affected By Dentin sialophosphoprotein (DSPP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[435]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[672]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[457]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[190]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[673]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[674]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[675]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[676]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[677]
phenamil	DMJLUFM	Discovery agent	N.A.	Investigative	[672]

Drug(s) Affected By 7-dehydrocholesterol reductase (DHCR7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[162]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[165]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[405]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[160]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[257]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[230]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[285]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[678]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[189]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[177]

Drug(s) Affected By CD2-associated protein (CD2AP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[293]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[207]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[317]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[310]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[315]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[679]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[293]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[680]

Drug(s) Affected By Cytochrome b-245 light chain (CYBA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[681]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[165]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[682]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[167]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[683]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[684]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[259]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[182]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[593]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[201]

Drug(s) Affected By 5-hydroxytryptamine receptor 7 (HTR7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[257]
Cyproheptadine	DM92AH3	Allergic rhinitis	CA08.0	Approved	[685]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[685]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[253]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[686]
PD-0325901	DM27D4J	Breast cancer	2C60-2C65	Phase 2	[193]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[220]
SL65.0472	DMU5RKC	Cardiovascular disease	BA00-BE2Z	Discontinued in Phase 2	[687]
SB-269970	DM8WTGA	Sleep-wake disorder	7A00-7B2Z	Terminated	[685]
ICI-169369	DMQ0IOF	Anxiety disorder	6B00-6B0Z	Terminated	[685]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 10 (TNFSF10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[688]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[379]
Selenium	DM25CGV	N. A.	N. A.	Approved	[162]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[689]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[690]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[381]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[165]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[592]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[638]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[691]

Drug(s) Affected By Small ribosomal subunit protein mS31 (MRPS31)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[165]
Haloperidol	DM96SE0	Delirium		Approved	[210]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[177]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[593]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[201]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[207]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[253]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[317]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[310]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[332]

Drug(s) Affected By Sterol regulatory element-binding protein cleavage-activating protein (SCAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[206]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[253]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[228]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[317]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[332]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[692]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[220]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[293]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[693]

Drug(s) Affected By Kinesin-like protein KIF6 (KIF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[694]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[206]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[317]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[596]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[395]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[675]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[695]
Rosuvastatin	DMMIQ7G	Arteriosclerosis	BD40	Approved	[695]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[395]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[696]

Drug(s) Affected By Collagen alpha-1(XIII) chain (COL13A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[309]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[201]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[239]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[278]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[394]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[225]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[697]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[596]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[332]

Drug(s) Affected By 5-hydroxytryptamine receptor 3B (HTR3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[317]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[220]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[320]

Drug(s) Affected By ELL-associated factor 2 (EAF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[165]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[257]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[698]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[699]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[150]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[206]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[698]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[538]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[608]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
HMG-CoA reductase (HMGCR)	TTPADOQ	HMDH_HUMAN	Inhibitor	[3]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Breast cancer resistance protein (ABCG2)	DTI7UX6	ABCG2_HUMAN	Substrate	[4]
Organic anion transporting polypeptide 1B1 (SLCO1B1)	DT3D8F0	SO1B1_HUMAN	Substrate	[5]
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[6]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4) Main DME	DE4LYSA	CP3A4_HUMAN	Substrate	[7]
Cytochrome P450 2D6 (CYP2D6)	DECB0K3	CP2D6_HUMAN	Substrate	[8]
UDP-glucuronosyltransferase 1A1 (UGT1A1)	DEYGVN4	UD11_HUMAN	Substrate	[9]
Mephenytoin 4-hydroxylase (CYP2C19)	DEGTFWK	CP2CJ_HUMAN	Substrate	[9]
Cytochrome P450 3A5 (CYP3A5) Main DME	DEIBDNY	CP3A5_HUMAN	Substrate	[10]
Cytochrome P450 2C8 (CYP2C8)	DES5XRU	CP2C8_HUMAN	Substrate	[11]
UDP-glucuronosyltransferase 2B7 (UGT2B7)	DEB3CV1	UD2B7_HUMAN	Substrate	[9]
UDP-glucuronosyltransferase 1A3 (UGT1A3)	DEF2WXN	UD13_HUMAN	Substrate	[9]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (PLCG2)	OTGVC9MY	PLCG2_HUMAN	Gene/Protein Processing	[12]
5-hydroxytryptamine receptor 3B (HTR3B)	OTMGIYRE	5HT3B_HUMAN	Drug Response	[13]
5-hydroxytryptamine receptor 7 (HTR7)	OT44DEWB	5HT7R_HUMAN	Drug Response	[13]
7-dehydrocholesterol reductase (DHCR7)	OTLILBUI	DHCR7_HUMAN	Gene/Protein Processing	[14]
Aldehyde dehydrogenase, dimeric NADP-preferring (ALDH3A1)	OTAYZZE6	AL3A1_HUMAN	Gene/Protein Processing	[12]
Aldo-keto reductase family 1 member C1 (AKR1C1)	OTQKR4CM	AK1C1_HUMAN	Gene/Protein Processing	[12]
Aldo-keto reductase family 1 member C3 (AKR1C3)	OTU2SXBA	AK1C3_HUMAN	Gene/Protein Processing	[15]
Alpha-actinin-4 (ACTN4)	OTCNZAJ5	ACTN4_HUMAN	Gene/Protein Processing	[16]
Alpha-catulin (CTNNAL1)	OTESJ6JD	CTNL1_HUMAN	Gene/Protein Processing	[12]
Amyloid-beta precursor protein (APP)	OTKFD7R4	A4_HUMAN	Gene/Protein Processing	[17]

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