Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM4O2Z7)

• Drug Name: Cyclophosphamide Drug Info
• Synonyms: ASTA; Ciclofosfamida; Ciclophosphamide; Clafen; Claphene; Cycloblastin; Cyclophosphamid; Cyclophosphamides; Cyclophosphamidum; Cyclophosphan; Cyclophosphane; Cyclophosphanum; Cyclophosphoramide; Cyclostin; Cyklofosfamid; Cytophosphan; Cytophosphane; Cytoxan; Endoxan; Endoxana; Endoxanal; Endoxane; Enduxan; Genoxal; Mitoxan; Neosar; Procytox; Revimmune; Semdoxan; Sendoxan; Senduxan; Zyklophosphamid; Ciclophosphamide [INN]; Cyclophosphamide Sterile; Cyclophosphamide anhydrous; Cyklofosfamid [Czech]; Cytoxan Lyoph; Endoxan R; Lyophilized Cytoxan; Zyklophosphamid [German]; ASTA B518; Asta B 518; B 518; C 0768; CB 4564; SK 20501; B-518; CB-4564; Ciclofosfamida [INN-Spanish]; Cyclophosphamide (INN); Cyclophosphamide (TN); Cyclophosphamide (anhydrous form); Cyclophosphamide (anhydrous); Cyclophosphamidum [INN-Latin]; Cytoxan (TN); Endoxan (TN); Endoxan-Asta; Neosar (TN); Occupation, cyclophosphamide exposure; Procytox (TN); Revimmune (TN); Bis(2-Chloroethyl)phosphami de cyclic propanolamide; Bis(2-Chloroethyl)phosphamide cyclic propanolamide ester; Bis(2-chloroethyl)phosphoramide cyclic propanolamide ester; D,L-Cyclophosphamide; Cyclophosphamide, (+-)-Isomer; N,N-Bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide; (+-)-Cyclophosphamide; (-)-Cyclophosphamide; (RS)-Cyclophosphamide; 1-(bis(2-chloroethyl)amino)-1-oxo-2-aza-5-oxaphosphoridine; 1-Bis(2-chloroethyl)amino-1-oxo-2-aza-5-oxaphosphoridin; 4-Hydroxy-cyclophosphan-mamophosphatide

Indication

Disease Entry	ICD 11	Status	REF
Advanced cancer	2A00-2F9Z	Approved	[1]
Central nervous system neoplasm		Approved	[1]
Glioblastoma	2A00	Approved	[1]
Immunodeficiency	4A00-4A85	Approved	[1]
Inflammatory breast cancer	2C62	Approved	[1]
Lupus nephritis	4A40.0Y	Approved	[1]
Lymphoma	2A80-2A86	Approved	[1]
Multiple sclerosis	8A40	Approved	[1]
Mycosis fungoides	2B01	Approved	[1]
Plasma cell myeloma	2A83.1	Approved	[1]
Solid tumour/cancer	2A00-2F9Z	Approved	[2]
Classic Hodgkin lymphoma		Investigative	[1]
Neuroblastoma	2D11.2	Investigative	[1]
Retinoblastoma	2D02.2	Investigative	[1]
Scleroderma	4A42	Investigative	[1]

• Therapeutic Class: Anticancer Agents
• Cross-matching ID:
  PubChem CID: 2907
  ChEBI ID: CHEBI:4027
  CAS Number: CAS 50-18-0
  TTD Drug ID: DM4O2Z7
  VARIDT Drug ID: DR00425
  INTEDE Drug ID: DR0391
  ACDINA Drug ID: D00157

Molecule-Related Drug Atlas

Drug(s) Targeting Human Deoxyribonucleic acid (hDNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[18]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[19]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[20]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[21]
Carboplatin	DMG281S	Adenocarcinoma	2D40	Approved	[22]
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[23]
Procarbazine	DMIK367	Hodgkin lymphoma	2B30	Approved	[24]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[25]
Dacarbazine	DMNPZL4	Adenocarcinoma	2D40	Approved	[26]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[27]

Drug(s) Transported By Multidrug resistance-associated protein 4 (ABCC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[28]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[29]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[30]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[31]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[32]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[33]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[34]
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[35]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[36]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[32]

Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[37]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[38]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[39]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[40]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[41]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[42]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[43]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[44]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[38]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[45]
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[100]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[101]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[102]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[103]
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[104]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[104]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[105]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[106]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[107]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[108]

Drug(s) Metabolized By Cytochrome P450 2A6 (CYP2A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[46]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[11]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[47]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[41]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[11]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[48]
Metronidazole	DMTIVEN	Abscess		Approved	[49]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[50]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[11]

Drug(s) Metabolized By Cytochrome P450 3A7 (CYP3A7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[52]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[53]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[53]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[53]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[11]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[54]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[53]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[53]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[53]
Metronidazole	DMTIVEN	Abscess		Approved	[49]

Drug(s) Metabolized By Cytochrome P450 2C18 (CYP2C18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[11]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[55]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[50]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[11]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[57]
Methadone	DMTW6IU	Advanced cancer	2A00-2F9Z	Approved	[58]
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[59]
Lidocaine	DML4ZOT	Anaesthesia	9A78.6	Approved	[11]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[60]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[87]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Lansoprazole	DMXYLQ3	Gastric ulcer	DA60	Approved	[93]
Warfarin	DMJYCVW	Atrial fibrillation	BC81.3	Approved	[94]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[95]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[91]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[98]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[99]

Drug(s) Metabolized By Cytochrome P450 2C8 (CYP2C8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[46]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[61]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[61]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[11]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[62]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[63]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[64]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[61]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[65]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[50]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[86]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[86]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[87]
Sulfinpyrazone	DMEV954	Gout	FA25	Approved	[88]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[86]
Zafirlukast	DMHNQOG	Asthma	CA23	Approved	[86]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[86]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[89]
Dabrafenib	DMX6OE3	Melanoma	2C30	Approved	[90]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[91]

Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[66]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[67]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[68]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[11]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[69]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[11]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[70]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[71]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[72]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[73]

Drug(s) Metabolized By Cytochrome P450 2B6 (CYP2B6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[74]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[11]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[75]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[68]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[77]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[78]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[79]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[80]
Amitriptyline	DMK7F9S	Depression	6A70-6A7Z	Approved	[81]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[109]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[110]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[111]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[112]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[113]
Clopidogrel	DMOL54H	Acute coronary syndrome	BA41	Approved	[114]
Artemisinin	DMOY7W3	Malaria	1F40-1F45	Approved	[115]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[116]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[117]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[118]

Drug(s) Metabolized By Mephenytoin 4-hydroxylase (CYP2C19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[82]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[66]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[7]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[83]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[11]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[84]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[73]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[85]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[50]

Drug(s) Affected By Glucose-6-phosphate 1-dehydrogenase (G6PD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[119]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[120]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[121]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[122]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[123]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[125]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[126]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[127]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[128]

Drug(s) Affected By Cytochrome P450 2D6 (CYP2D6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[129]
Paliperidone	DM7NPJS	Psychotic disorder	6A20-6A25	Approved	[130]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[131]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[132]
Oxatomide	DM1F42Z	Hay fever	CA08.00	Approved	[133]
Cinacalcet	DMCX0K3	Hyperparathyroidism	5A51	Approved	[134]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[135]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[104]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[136]
Buprenorphine	DMPRI8G	Opioid dependence	6C43.2Z	Approved	[137]

Drug(s) Affected By Cholinesterase (BCHE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[138]
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[139]
Galantamine	DMEO794	Alzheimer disease	8A20	Approved	[140]
Rivastigmine	DMG629M	Alzheimer disease	8A20	Approved	[141]
Donepezil	DMIYG7Z	Advanced cancer	2A00-2F9Z	Approved	[142]
Succinylcholine	DM2ET1M	Plasma cell myeloma	2A83.1	Approved	[143]
Ethopropazine	DM0N3L7	Parkinson disease	8A00.0	Approved	[139]
Dimenhydrinate	DM264B3	Meniere disease	AB31.0	Approved	[144]
Chlorpheniramine	DM5URA2	Allergic rhinitis	CA08.0	Approved	[144]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[145]

Drug(s) Affected By Actin, cytoplasmic 1 (ACTB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[146]
Selenium	DM25CGV	N. A.	N. A.	Approved	[147]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[148]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[145]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[124]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[152]

Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[153]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[154]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[155]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[156]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[157]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[158]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[159]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[160]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[161]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[162]

Drug(s) Affected By Band 4.1-like protein 2 (EPB41L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[163]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[164]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[152]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[165]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[166]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[167]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[168]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[169]

Drug(s) Affected By Receptor activity-modifying protein 1 (RAMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[170]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[171]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[171]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[172]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[173]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[174]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[175]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[176]

Drug(s) Affected By Cystatin-F (CST7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[170]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[177]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[178]
Bortezomib	DMNO38U	Leukemia		Approved	[179]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[180]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[181]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[176]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[182]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[183]

Drug(s) Affected By Kelch repeat and BTB domain-containing protein 11 (KBTBD11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[184]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[185]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[186]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[187]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[172]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[168]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[174]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[188]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[189]

Drug(s) Affected By Aldehyde dehydrogenase 1A1 (ALDH1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[190]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[191]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[192]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[193]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[194]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[195]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[196]

Drug(s) Affected By Carbonic anhydrase 2 (CA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetazolamide	DM1AF5U	Absence epilepsy		Approved	[197]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[198]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[199]
Methazolamide	DM7J2TA	Glaucoma/ocular hypertension	9C61	Approved	[200]
Topiramate	DM82Z30	Alcohol dependence	6C40.2	Approved	[201]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[202]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[203]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[204]

Drug(s) Affected By Aldehyde dehydrogenase, mitochondrial (ALDH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[206]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[208]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[186]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[152]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[209]

Drug(s) Affected By Tyrosine-protein kinase Fyn (FYN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[210]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[211]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[212]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[91]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[213]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[180]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[214]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[215]

Drug(s) Affected By Procathepsin L (CTSL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[216]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[186]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[152]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[217]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[165]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[218]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[216]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[213]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[180]

Drug(s) Affected By Galectin-1 (LGALS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[121]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[219]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[145]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[220]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[221]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[222]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[223]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[224]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]

Drug(s) Affected By SPARC (SPARC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[225]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[226]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[186]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[226]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[227]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[228]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[229]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[230]

Drug(s) Affected By Pro-cathepsin H (CTSH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[231]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[184]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[163]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[232]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[186]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[172]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[233]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[230]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[213]

Drug(s) Affected By Non-secretory ribonuclease (RNASE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[223]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Salmeterol	DMIEU69	Allergic asthma	CA23.0	Approved	[234]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[119]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[235]
Beclomethasone dipropionate	DM5NW1E	Allergic rhinitis	CA08.0	Phase 4	[234]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[236]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[237]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[238]

Drug(s) Affected By Transcriptional regulator ERG (ERG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[186]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[235]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[239]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[240]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[241]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[241]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[237]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[240]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[242]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[242]

Drug(s) Affected By Tissue factor (F3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[243]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[244]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[245]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[246]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[247]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[248]
Fructose	DM43AN2	Vomiting	MD90	Approved	[249]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[250]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[244]
Desloratadine	DM56YN7	Allergic rhinitis	CA08.0	Approved	[244]

Drug(s) Affected By Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[147]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[219]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[251]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[126]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[232]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[164]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[252]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[152]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[181]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[253]

Drug(s) Affected By Methylated-DNA--protein-cysteine methyltransferase (MGMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[254]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[255]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[256]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[152]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[257]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[258]
Dacarbazine	DMNPZL4	Adenocarcinoma	2D40	Approved	[259]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[260]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[260]

Drug(s) Affected By Bactericidal permeability-increasing protein (BPI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[211]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[163]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[211]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[237]

Drug(s) Affected By Arachidonate 5-lipoxygenase-activating protein (ALOX5AP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[163]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[261]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[211]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[262]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[263]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[164]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[179]
Warfarin	DMJYCVW	Atrial fibrillation	BC81.3	Approved	[264]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[233]

Drug(s) Affected By Interferon-induced GTP-binding protein Mx2 (MX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[265]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[266]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[267]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[172]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[173]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[268]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[269]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[239]

Drug(s) Affected By Amine oxidase A (MAOA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[270]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[271]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[272]
Selegiline	DM6034S	Major depressive disorder	6A70.3	Approved	[273]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[163]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[274]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
BENZYL BENZOATE	DMDPYI5	Infestations of lice and scabies	1G00.Z	Approved	[275]

Drug(s) Affected By Myeloblastin (PRTN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[170]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[276]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Pazopanib	DMF57DM	N. A.	N. A.	Approved	[277]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[278]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[119]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[279]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[280]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[281]

Drug(s) Affected By Protein S100-P (S100P)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[282]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[283]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[154]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[284]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[199]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[285]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[286]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[287]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[171]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[171]

Drug(s) Affected By Caspase-1 (CASP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[288]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[289]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[290]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[291]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[292]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[284]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[184]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[293]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[294]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[295]

Drug(s) Affected By Myristoylated alanine-rich C-kinase substrate (MARCKS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[147]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[296]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[296]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[297]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[295]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[164]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[266]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[298]

Drug(s) Affected By Transmembrane 4 L6 family member 1 (TM4SF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[95]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[145]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[171]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[202]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[299]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[186]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[152]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[300]

Drug(s) Affected By Intercellular adhesion molecule 3 (ICAM3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[211]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[185]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[163]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[301]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[302]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[172]

Drug(s) Affected By P2Y purinoceptor 2 (P2RY2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[284]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[303]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[304]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[303]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[186]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[213]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[278]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[188]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[305]
Chlorothiazide	DMLHESP	Chronic heart failure	BD1Z	Approved	[306]

Drug(s) Affected By Glycine receptor subunit beta (GLRB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[307]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[308]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[186]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[253]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[309]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[305]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[254]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[254]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[185]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[310]

Drug(s) Affected By C-C chemokine receptor type 8 (CCR8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[311]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[223]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[312]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[237]

Drug(s) Affected By Ras-related protein R-Ras2 (RRAS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[313]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[314]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[297]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[223]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[152]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[315]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[172]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[173]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[316]

Drug(s) Affected By Bcl-2-interacting killer (BIK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[317]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[318]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[319]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[293]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[164]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[186]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[320]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[321]

Drug(s) Affected By Angiopoietin-1 (ANGPT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[322]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Selenium	DM25CGV	N. A.	N. A.	Approved	[147]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[323]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[324]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[185]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[145]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[266]

Drug(s) Affected By Fascin (FSCN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[325]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[271]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[184]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[326]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[287]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[298]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[152]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[179]

Drug(s) Affected By Pleckstrin homology-like domain family A member 2 (PHLDA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[271]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[327]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[126]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[185]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[163]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[300]

Drug(s) Affected By Testis-expressed protein 30 (TEX30)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[171]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[171]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[152]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[328]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[329]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[278]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[98]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[309]

Drug(s) Affected By Ras-related GTP-binding protein A (RRAGA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[331]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[172]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[213]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[253]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[236]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[332]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[147]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[237]
RESORCINOL	DMM37C0	Discovery agent	N.A.	Investigative	[165]

Drug(s) Affected By Cilium assembly protein DZIP1 (DZIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[95]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[286]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[164]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[165]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[213]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[175]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[333]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[333]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[237]

Drug(s) Affected By RNA-binding protein with multiple splicing (RBPMS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Selenium	DM25CGV	N. A.	N. A.	Approved	[147]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[307]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[126]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[145]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[223]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[178]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[214]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[175]

Drug(s) Affected By Membrane-spanning 4-domains subfamily A member 3 (MS4A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[225]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[235]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[237]
Butanoic Acid	DMTAJP7	Discovery agent	N.A.	Investigative	[225]

Drug(s) Affected By Rho GTPase-activating protein 7 (DLC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[265]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[307]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[185]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[334]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[335]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[336]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[213]

Drug(s) Affected By MyoD family inhibitor domain-containing protein (MDFIC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[307]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[185]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[202]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[168]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[337]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[338]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[253]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[309]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[252]

Drug(s) Affected By Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 (GNG12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[331]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[152]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[168]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[98]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[252]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[237]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[339]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[340]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[341]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-5 (ATF5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[147]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[272]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[263]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[164]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[342]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[343]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[336]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[344]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[173]

Drug(s) Affected By PALM2-AKAP2 fusion protein (PALM2AKAP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[147]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[211]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[145]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[266]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[345]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[214]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[175]

Drug(s) Affected By Dihydropyrimidinase-related protein 4 (DPYSL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[12]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[295]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[120]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[172]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[173]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[12]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[213]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[168]

Drug(s) Affected By Integral membrane protein GPR137B (GPR137B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[147]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[12]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[199]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[171]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[171]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[124]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[186]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[298]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[172]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[165]

Drug(s) Affected By Glutaminase kidney isoform, mitochondrial (GLS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[265]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[271]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[307]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[346]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[185]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[145]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[202]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[226]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[347]

Drug(s) Affected By Urokinase-type plasminogen activator (PLAU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[12]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[265]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[348]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[271]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[272]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[185]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[349]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[150]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[350]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]

Drug(s) Affected By Ubiquitin-like protein ISG15 (ISG15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[296]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[219]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[296]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[351]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[286]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[266]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[267]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[186]

Drug(s) Affected By Early growth response protein 1 (EGR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[352]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[154]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[265]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[353]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[354]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[355]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[356]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[145]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[357]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[171]

Drug(s) Affected By Stomatin (STOM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[12]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[327]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[164]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[152]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[173]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[12]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[213]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[181]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[358]

Drug(s) Affected By Cellular retinoic acid-binding protein 2 (CRABP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[12]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[359]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[360]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[185]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[232]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[223]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[361]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[172]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[233]

Drug(s) Affected By Tyrosine-protein kinase receptor UFO (AXL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[147]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[12]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[362]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[363]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[150]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[364]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[364]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[364]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[365]

Drug(s) Affected By 14-3-3 protein sigma (SFN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[366]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[367]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[368]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[12]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[369]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[314]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[185]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[370]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[371]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[364]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[372]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[373]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[374]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[375]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[376]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[154]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[377]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[378]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[379]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[380]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 9 (TNFSF9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[380]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[170]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[12]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[381]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[232]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[364]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[186]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[364]

Drug(s) Affected By Galectin-7 (LGALS7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[12]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[152]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[12]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[175]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[176]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[185]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[382]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[237]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[383]

Drug(s) Affected By Rho GDP-dissociation inhibitor 2 (ARHGDIB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[170]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[12]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[219]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[126]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[145]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[150]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[187]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[172]

Drug(s) Affected By Epithelial membrane protein 1 (EMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[12]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[125]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[125]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[185]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[232]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[295]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[171]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]

Drug(s) Affected By Epithelial membrane protein 3 (EMP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[147]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[12]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[384]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[145]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[263]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[186]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[152]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[321]

Drug(s) Affected By Protein ripply3 (RIPPLY3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[12]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[307]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[336]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[12]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[213]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[385]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[168]

Drug(s) Affected By Pro-neuregulin-1, membrane-bound isoform (NRG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[366]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[95]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[270]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[271]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[307]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[185]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[386]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[387]

Drug(s) Affected By Antigen peptide transporter 1 (TAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Selenium	DM25CGV	N. A.	N. A.	Approved	[147]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[12]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[211]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[262]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[186]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[298]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[152]

Drug(s) Affected By Laminin subunit gamma-2 (LAMC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[366]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[388]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[12]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[389]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[185]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[347]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[390]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[152]

Drug(s) Affected By Filamin-C (FLNC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[95]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[12]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[263]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[152]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[172]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[12]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[213]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[119]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[231]

Drug(s) Affected By Immediate early response gene 5 protein (IER5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[12]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[307]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[186]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[336]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[165]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[12]

Drug(s) Affected By Keratin, type II cytoskeletal 80 (KRT80)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[12]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[286]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[171]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[171]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[223]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[336]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[172]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[233]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[12]

Drug(s) Affected By Neuropilin and tolloid-like protein 2 (NETO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[12]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[272]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[391]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[164]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[172]
Bortezomib	DMNO38U	Leukemia		Approved	[179]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[392]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[119]

Drug(s) Affected By UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2 (B3GALNT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[339]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[393]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[394]

Drug(s) Affected By Phospholipase ABHD3 (ABHD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[373]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[12]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[311]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[171]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[202]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[331]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[213]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[278]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[181]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 14 (TNFRSF14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[211]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[128]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[381]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[395]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[396]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[321]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[336]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[172]

Drug(s) Affected By Major histocompatibility complex class I-related gene protein (MR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[397]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[397]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[397]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[397]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[397]
Repaglinide	DM5SXUV	Diabetic complication	5A2Y	Approved	[397]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[386]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 27 (EDA2R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[364]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[312]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[398]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[236]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[237]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[339]

Drug(s) Affected By Stathmin-3 (STMN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[12]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[124]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[172]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[213]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[168]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[175]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[399]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[253]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 6 (SLC2A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[400]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[164]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[172]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[173]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[12]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[278]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[253]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[236]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[401]

Drug(s) Affected By Endothelial protein C receptor (PROCR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[368]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[12]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[186]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[152]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[173]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[12]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[213]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[385]

Drug(s) Affected By Serine/threonine-protein kinase Sgk1 (SGK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[402]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[403]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[404]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[380]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[272]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[402]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[405]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[232]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[406]

Drug(s) Affected By Interferon-related developmental regulator 1 (IFRD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[231]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[271]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[126]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[332]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[286]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[407]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[124]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[213]

Drug(s) Affected By Kinesin-like protein KIF21B (KIF21B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[272]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[163]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[164]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[394]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[278]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[181]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[188]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[253]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[408]

Drug(s) Affected By Large neutral amino acids transporter small subunit 3 (SLC43A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[346]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[185]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[14]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[171]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[171]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[223]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[365]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[346]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[177]

Drug(s) Affected By Cystatin-A (CSTA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[409]
Selenium	DM25CGV	N. A.	N. A.	Approved	[147]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[368]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[219]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[145]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[410]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[298]

Drug(s) Affected By Amino acid transporter heavy chain SLC3A2 (SLC3A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[147]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[411]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[271]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[400]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[346]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[14]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[232]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[364]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[150]

Drug(s) Affected By Asparagine synthetase (ASNS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[352]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[412]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[231]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[412]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[411]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[296]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[413]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[412]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[271]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]

Drug(s) Affected By Endoplasmic reticulum chaperone BiP (HSPA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[414]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[415]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[416]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[148]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[417]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[418]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[419]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[420]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[421]

Drug(s) Affected By Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial (MTHFD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[411]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[272]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[14]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[232]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[331]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[152]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[172]

Drug(s) Affected By CCAAT/enhancer-binding protein beta (CEBPB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[282]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[265]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[422]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[423]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[424]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[271]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[211]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[185]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[425]

Drug(s) Affected By Protein EVI2A (EVI2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[14]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[14]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[263]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[172]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[338]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[99]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[237]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[426]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[427]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[154]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[428]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[429]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[430]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[431]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[432]
Fructose	DM43AN2	Vomiting	MD90	Approved	[249]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[427]
Vismodegib	DM5IXKQ	Basal cell carcinoma	2C32	Approved	[433]

Drug(s) Affected By DnaJ homolog subfamily B member 1 (DNAJB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[434]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[352]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[289]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[346]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[435]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[206]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[436]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[437]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[150]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[352]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[438]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[439]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[440]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[415]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[154]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[417]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[441]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[191]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]

Drug(s) Affected By B-cell lymphoma 6 protein (BCL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[14]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[14]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[187]
Bortezomib	DMNO38U	Leukemia		Approved	[179]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[213]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[385]

Drug(s) Affected By Radiation-inducible immediate-early gene IEX-1 (IER3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[282]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[146]
Selenium	DM25CGV	N. A.	N. A.	Approved	[442]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[271]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[211]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[126]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[185]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[286]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[232]

Drug(s) Affected By Cysteine--tRNA ligase, cytoplasmic (CARS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[443]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[265]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[444]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[364]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[364]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[394]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[364]

Drug(s) Affected By Sestrin-2 (SESN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[352]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[445]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[191]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[271]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[346]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[14]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[446]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[352]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[150]

Drug(s) Affected By Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[120]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[95]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[447]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[447]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[448]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[447]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[314]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[91]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[211]

Drug(s) Affected By DNA-binding protein inhibitor ID-2 (ID2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[225]
Selenium	DM25CGV	N. A.	N. A.	Approved	[147]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[449]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[314]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[450]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[346]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[163]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[449]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[232]

Drug(s) Affected By Early activation antigen CD69 (CD69)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[211]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[451]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[407]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[298]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[177]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[336]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[452]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[345]

Drug(s) Affected By Transmembrane protein 267 (TMEM267)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[14]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[186]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[336]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[453]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[98]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[309]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[14]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 3 (BIRC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[454]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[455]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[95]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[428]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[270]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[314]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[272]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[456]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[457]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[286]

Drug(s) Affected By Isopentenyl-diphosphate Delta-isomerase 1 (IDI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[448]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[458]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[314]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[126]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[186]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[152]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[120]

Drug(s) Affected By N-arachidonyl glycine receptor (GPR18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[459]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[459]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[460]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[14]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[14]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[238]
Rapamycin Immunosuppressant Drug	DM678IB	Discovery agent	N.A.	Investigative	[14]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[393]

Drug(s) Affected By Nuclear receptor coactivator 7 (NCOA7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[272]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[185]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[386]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[223]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[298]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[152]

Drug(s) Affected By Alanine aminotransferase 2 (GPT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[461]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[346]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[14]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[263]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[346]

Drug(s) Affected By Nanos homolog 1 (NANOS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[307]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[185]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[232]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[164]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[179]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[173]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[178]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[168]

Drug(s) Affected By Heat shock protein 105 kDa (HSPH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[354]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[346]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[381]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[436]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[357]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[223]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[186]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[152]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[346]

Drug(s) Affected By Insulin gene enhancer protein ISL-2 (ISL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[14]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[164]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[407]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[213]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[278]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[236]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[14]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[339]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[14]

Drug(s) Affected By E3 ubiquitin-protein ligase pellino homolog 1 (PELI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[14]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[164]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[185]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[336]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[213]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[462]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[278]

Drug(s) Affected By Centriolar and ciliogenesis-associated protein HYLS1 (HYLS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[446]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[164]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[298]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[172]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[213]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[119]

Drug(s) Affected By Tribbles homolog 3 (TRIB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[352]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[91]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[327]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[346]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[370]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[14]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[286]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[436]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[232]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[150]

Drug(s) Affected By Glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[352]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[185]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[459]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[463]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[352]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[299]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[459]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Racecadotril	DMFOTZ7	Diarrhea	ME05.1	Approved	[464]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[179]

Drug(s) Affected By Transmembrane 6 superfamily member 1 (TM6SF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[14]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[347]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Racecadotril	DMFOTZ7	Diarrhea	ME05.1	Approved	[464]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[328]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[168]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[175]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[465]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[466]

Drug(s) Affected By Protein FAM107B (FAM107B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[443]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[327]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[14]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[295]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[202]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[150]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[14]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[298]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[172]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[213]

Drug(s) Affected By Lysine-rich coiled-coil protein 1 (KRCC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[164]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[186]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[179]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[213]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[235]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[467]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[253]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[236]

Drug(s) Affected By DnaJ homolog subfamily B member 4 (DNAJB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[352]
Selenium	DM25CGV	N. A.	N. A.	Approved	[147]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[354]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[346]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[163]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[468]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[436]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[352]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[223]

Drug(s) Affected By SLAM family member 5 (CD84)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[14]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[14]
Epanova	DMHEAGL	Hypertriglyceridemia	5C80.1	Approved	[469]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[470]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[14]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[269]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[182]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[237]
Rapamycin Immunosuppressant Drug	DM678IB	Discovery agent	N.A.	Investigative	[14]

Drug(s) Affected By Cystine/glutamate transporter (SLC7A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[471]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[472]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[461]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[472]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[472]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[296]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[473]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[14]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[472]

Drug(s) Affected By Nuclear factor erythroid 2-related factor 3 (NFE2L3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[307]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[179]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[172]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[165]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[213]

Drug(s) Affected By Dual specificity protein phosphatase 10 (DUSP10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[439]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[474]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[125]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[125]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[185]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[14]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[436]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[202]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]

Drug(s) Affected By Apoptotic protease-activating factor 1 (APAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[288]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[270]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[284]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[391]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[475]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[255]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[394]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[152]
Momelotinib	DMF98Q0	Myelofibrosis	2A20.2	Approved	[476]

Drug(s) Affected By Transmembrane protease serine 2 (TMPRSS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[17]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[17]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Selenium	DM25CGV	N. A.	N. A.	Approved	[147]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[17]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[17]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[17]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[17]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[17]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[17]

Drug(s) Affected By Growth arrest-specific protein 2 (GAS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[307]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[213]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[98]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[97]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[477]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[252]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[236]

Drug(s) Affected By Lysine-specific histone demethylase 1A (KDM1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[478]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[479]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[202]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[331]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[152]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[213]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[252]
Berberine	DMC5Q8X	N. A.	N. A.	Phase 4	[480]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[481]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[237]

Drug(s) Affected By Slit homolog 1 protein (SLIT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[272]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[185]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[482]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[482]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[482]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[483]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[156]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[185]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[185]

Drug(s) Affected By DnaJ homolog subfamily B member 6 (DNAJB6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[346]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[434]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[164]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[186]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[152]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[346]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[172]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[213]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[484]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[169]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[485]
Vidarabine	DM0N85H	Hepatosplenic T-cell lymphoma		Approved	[485]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[486]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[487]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[488]
Etidronic acid	DM1XHYJ	Bone Paget disease		Approved	[485]
Tiaprofenic acid	DM23D7J	Osteoarthritis	FA00-FA05	Approved	[485]
Bromperidol	DM24XYQ	Schizophrenia	6A20	Approved	[485]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[489]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[490]

Drug(s) Affected By Follitropin subunit beta (FSHB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[491]
Goserelin	DMAT8CG	Breast cancer	2C60-2C65	Approved	[492]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[300]
Cetrorelix	DMFD9Q6	Ovarian stimulation	LB45.1	Approved	[493]
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[494]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[495]
Risperidone	DMN6DXL	Bipolar I disorder		Approved	[496]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[497]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[213]
Naltrexone	DMUL45H	Alcohol dependence	6C40.2	Approved	[498]

Drug(s) Affected By Thymidine kinase, cytosolic (TK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[499]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[500]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[154]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[501]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[314]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[271]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[199]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[502]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[171]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[171]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[503]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[170]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[504]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[505]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[506]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[507]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[508]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[509]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[510]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[511]

Drug(s) Affected By Endothelin-1 (EDN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[512]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[223]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[513]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[270]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[514]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[515]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[211]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[516]
Lisinopril	DMUOK4C	Chronic heart failure	BD1Z	Approved	[517]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[185]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[518]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[519]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[520]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[521]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[522]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[523]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[524]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[525]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[526]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[524]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[527]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[352]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[162]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[528]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[529]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[530]
Selenium	DM25CGV	N. A.	N. A.	Approved	[531]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[532]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[533]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[270]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[282]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[534]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[535]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[428]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[536]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[379]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[536]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[537]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[538]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[539]

Drug(s) Affected By Heat shock 70 kDa protein 1A (HSPA1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[540]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[352]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[439]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[289]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[154]
Selenium	DM25CGV	N. A.	N. A.	Approved	[147]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[148]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[170]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[354]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[541]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[542]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[543]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[162]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[544]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[529]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[472]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[445]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[545]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[472]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[546]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[547]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[548]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[549]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[142]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[282]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[550]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[551]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[552]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[553]

Drug(s) Affected By Histone H2AX (H2AX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[554]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[555]
Selenium	DM25CGV	N. A.	N. A.	Approved	[147]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[556]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[557]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[558]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[473]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[559]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[560]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[561]

Drug(s) Affected By Natriuretic peptides B (NPPB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[562]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[265]
Rhucin	DM3ADGP	Erectile dysfunction	HA01.1	Approved	[563]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[307]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[564]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[223]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[565]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[566]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[567]

Drug(s) Affected By Troponin I, cardiac muscle (TNNI3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[272]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[411]
Perphenazine	DMA4MRX	Schizophrenia	6A20	Approved	[568]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[569]
Methamphetamine	DMPM4SK	Anxiety		Approved	[570]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[385]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[168]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[571]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[181]

Drug(s) Affected By Tumor necrosis factor alpha-induced protein 3 (TNFAIP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[572]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[282]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[573]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[271]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[574]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[332]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[457]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[572]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[220]

Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[352]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[439]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[367]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[575]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[411]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[318]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[12]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[353]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[576]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[577]

Drug(s) Affected By Endothelin receptor type B (EDNRB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[284]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[307]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[185]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[341]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[266]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[331]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[566]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[177]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[578]
Fenoterol	DMIP3ZV	Asthma	CA23	Approved	[579]

Drug(s) Affected By Insulin-like growth factor-binding protein 5 (IGFBP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[121]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[154]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[271]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[307]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[126]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[580]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[437]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[581]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[582]

Drug(s) Affected By DNA cytosine-5)-methyltransferase 1 (DNMT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[583]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[584]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[585]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[431]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[271]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[586]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[587]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[588]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[589]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[232]

Drug(s) Affected By Proteasome subunit alpha type-5 (PSMA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[126]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[351]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[232]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[152]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[321]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[590]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[309]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[236]

Drug(s) Affected By HLA class I histocompatibility antigen, alpha chain F (HLA-F)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[397]
Selenium	DM25CGV	N. A.	N. A.	Approved	[147]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[397]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[384]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[126]
Repaglinide	DM5SXUV	Diabetic complication	5A2Y	Approved	[397]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[591]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[331]
Saquinavir	DMG814N	Human immunodeficiency virus infection	1C62	Approved	[397]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[336]

Drug(s) Affected By Phospholipid hydroperoxide glutathione peroxidase GPX4 (GPX4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[592]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[593]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[145]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[152]
Gallium nitrate	DMF9O6B	Hypercalcaemia	5B91.0	Approved	[594]
Trabectedin	DMG3Y89	Leiomyosarcoma	2B58	Approved	[595]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[172]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[596]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[597]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[598]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[599]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[506]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[600]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[601]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[602]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[603]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[604]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[455]

Drug(s) Affected By Cytosolic purine 5'-nucleotidase (NT5C2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[605]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[186]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[152]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[482]
Bortezomib	DMNO38U	Leukemia		Approved	[179]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[213]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[482]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[482]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[175]

Drug(s) Affected By Tumor protein D52 (TPD52)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[572]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[272]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[145]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[572]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[263]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[164]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[152]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[606]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[229]

Drug(s) Affected By Potassium voltage-gated channel subfamily KQT member 4 (KCNQ4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[307]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Retigabine	DMGNYIH	Behcet disease	4A62	Approved	[607]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[482]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[482]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[482]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[175]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[188]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[608]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[609]

Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein K (HNRNPK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[610]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[611]
Haloperidol	DM96SE0	Delirium		Approved	[120]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[224]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[152]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[612]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[613]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[611]
PEITC	DMOMN31	Prostate cancer	2C82.0	Phase 2	[614]

Drug(s) Affected By Protein BTG2 (BTG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[154]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[380]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[211]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[615]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[128]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[145]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[446]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[220]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[171]

Drug(s) Affected By Runt-related transcription factor 3 (RUNX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[185]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[616]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[482]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[180]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[482]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[617]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[482]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[175]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[618]

Drug(s) Affected By Calicin (CCIN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[619]

Drug(s) Affected By Programmed cell death protein 4 (PDCD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[572]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[620]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[346]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[145]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[621]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[286]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[572]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[295]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[150]

Drug(s) Affected By Ribonucleoside-diphosphate reductase subunit M2 B (RRM2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[270]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[622]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[232]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[295]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[364]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[364]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[331]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[364]

Drug(s) Affected By Partitioning defective 3 homolog (PARD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[610]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[164]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[266]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[152]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[482]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[213]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[482]

Drug(s) Affected By GATOR1 complex protein NPRL2 (NPRL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[482]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[213]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[385]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[482]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[482]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[253]

Drug(s) Affected By F-box/WD repeat-containing protein 7 (FBXW7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[431]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[623]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[164]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[298]
Bortezomib	DMNO38U	Leukemia		Approved	[179]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[213]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[168]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[119]

Drug(s) Affected By Rho guanine nucleotide exchange factor 26 (ARHGEF26)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[95]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[286]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[164]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[152]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[482]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[213]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[482]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[482]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[624]

Drug(s) Affected By G-protein coupled receptor 20 (GPR20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[482]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[482]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[482]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[119]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[188]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[237]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[394]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[625]

Drug(s) Affected By Angiotensin-converting enzyme 2 (ACE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Captopril	DM458UM	Chronic heart failure	BD1Z	Approved	[626]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[17]
Dantrolene	DM1D8XY	Hyperthermia	MG26	Approved	[17]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[17]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[17]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[17]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[17]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[17]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[17]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[17]

Drug(s) Affected By Polyadenylate-binding protein-interacting protein 1 (PAIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[146]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[272]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[186]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[298]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[152]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[482]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[213]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[482]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[482]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[98]

Drug(s) Affected By Large subunit GTPase 1 homolog (LSG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[265]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[164]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[482]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[213]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[482]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[482]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[188]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[237]

Drug(s) Affected By Glyoxalase domain-containing protein 4 (GLOD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[211]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[152]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[612]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[482]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[482]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[482]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[627]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[253]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[211]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[339]

Drug(s) Affected By DNA-directed DNA/RNA polymerase mu (POLM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[482]
Bortezomib	DMNO38U	Leukemia		Approved	[179]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[482]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[482]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[383]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[253]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[237]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[610]
MK-886	DMT0O7H	Asthma	CA23	Discontinued in Phase 2	[628]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[610]

Drug(s) Affected By Ubiquitin-like-conjugating enzyme ATG3 (ATG3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[629]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[630]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[631]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[186]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[152]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[482]
Artesunate	DMR27C8	Infection of P. falciparum	1F40	Approved	[632]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[482]

Drug(s) Affected By Regulator of telomere elongation helicase 1 (RTEL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[211]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[235]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[181]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[236]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[211]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[237]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[610]

Drug(s) Affected By FK506-binding protein-like (FKBPL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[150]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[213]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[633]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[278]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[175]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[633]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[634]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[236]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[237]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[635]

Drug(s) Affected By Mitochondrial pyruvate carrier 2 (MPC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[152]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[336]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[636]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[213]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[278]

Drug(s) Affected By Krueppel-like factor 5 (KLF5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[411]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[307]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[185]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[163]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[295]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[171]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[223]

Drug(s) Affected By Galactocerebrosidase (GALC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[373]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[186]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[483]
Fenfluramine	DM0762O	Dravet syndrome	8A61.11	Phase 3	[637]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[185]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[182]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[237]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[95]

Drug(s) Affected By Granulocyte-macrophage colony-stimulating factor (CSF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[638]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[639]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[354]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[640]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[641]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[642]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[295]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[643]
Acetylcholine	DMDF79Z	Cataract	9B10	Approved	[644]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[645]

Drug(s) Affected By Superoxide dismutase (SOD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[646]
Haloperidol	DM96SE0	Delirium		Approved	[142]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[427]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[374]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[445]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[647]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[648]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[649]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[650]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[651]

Drug(s) Affected By Krueppel-like factor 4 (KLF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[352]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[199]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[652]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[653]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[352]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[654]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[202]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[616]

Drug(s) Affected By D-beta-hydroxybutyrate dehydrogenase, mitochondrial (BDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[126]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[386]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[152]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[172]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[173]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[627]

Drug(s) Affected By Melanoma-associated antigen D1 (MAGED1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[173]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[165]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[213]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[168]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[174]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[181]

Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[655]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[656]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[657]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[658]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[659]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[660]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[661]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[121]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[472]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[662]

Drug(s) Affected By Pro-adrenomedullin (ADM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[373]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[663]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[170]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[307]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[425]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[223]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[527]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase FKBP1B (FKBP1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[307]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[171]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[171]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[164]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[331]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[213]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[664]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[188]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[333]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[606]

Drug(s) Affected By L-lactate dehydrogenase B chain (LDHB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[91]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[351]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[222]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[223]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[224]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[152]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[91]

Drug(s) Affected By Epsilon-sarcoglycan (SGCE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[164]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[300]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[213]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[175]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[253]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[665]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[333]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[333]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[237]

Drug(s) Affected By Caspase-8 (CASP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[666]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[667]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[668]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[288]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[669]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[670]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[428]
Selenium	DM25CGV	N. A.	N. A.	Approved	[147]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[671]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[170]

Drug(s) Affected By Aldehyde dehydrogenase, dimeric NADP-preferring (ALDH3A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[672]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[362]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[111]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[192]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[286]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[196]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[172]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[168]

Drug(s) Affected By Sterol O-acyltransferase 1 (SOAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[164]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[186]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[152]
Epanova	DMHEAGL	Hypertriglyceridemia	5C80.1	Approved	[469]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[213]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[278]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[119]

Drug(s) Affected By Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[271]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[295]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[164]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[152]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[172]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[673]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[253]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[252]

Drug(s) Affected By Cochlin (COCH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[126]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[364]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[364]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[164]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[186]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[364]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[364]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[213]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[168]

Drug(s) Affected By Fibronectin type III domain-containing protein 3B (FNDC3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[272]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[164]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[331]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[152]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[214]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[175]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[98]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[674]

Drug(s) Affected By Tropomyosin alpha-1 chain (TPM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[443]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[148]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[295]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[164]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[224]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[394]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[152]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[173]
Bortezomib	DMNO38U	Leukemia		Approved	[179]

Drug(s) Affected By Very long chain fatty acid elongase 2 (ELOVL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[314]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[185]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[341]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[213]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[484]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[119]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[466]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[253]

Drug(s) Affected By Glutathione peroxidase 1 (GPX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[575]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[168]
Amlexanox	DM0DQM5	Respiratory tract inflammation	CA07	Approved	[675]
Selenium	DM25CGV	N. A.	N. A.	Approved	[592]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[676]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[677]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[354]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[219]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[678]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[679]

Drug(s) Affected By Protein AF1q (MLLT11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[12]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[314]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[391]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[252]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[336]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[172]
Bortezomib	DMNO38U	Leukemia		Approved	[179]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[230]

Drug(s) Affected By Troponin I, fast skeletal muscle (TNNI2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[282]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[213]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[168]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[175]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[181]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[680]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[142]

Drug(s) Affected By Multidrug resistance-associated protein 1 (ABCC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[681]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[682]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[683]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[684]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[685]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[453]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[686]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[687]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[688]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[688]

Drug(s) Affected By Tomoregulin-1 (TMEFF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[213]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[168]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[97]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[333]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[236]

Drug(s) Affected By DNA damage-inducible transcript 4 protein (DDIT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[352]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[225]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[380]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[368]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[689]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[307]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[346]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[386]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[446]

Drug(s) Affected By Ribosomal protein S6 kinase alpha-2 (RPS6KA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[95]
Selenium	DM25CGV	N. A.	N. A.	Approved	[147]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[314]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[286]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[186]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[690]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[691]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[692]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[385]

Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[530]
Selenium	DM25CGV	N. A.	N. A.	Approved	[442]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[296]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[693]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[650]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[694]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[324]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[314]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[695]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[199]

Drug(s) Affected By Insulin-like growth factor-binding protein 3 (IGFBP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[95]
Selenium	DM25CGV	N. A.	N. A.	Approved	[696]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[368]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[697]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[271]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[125]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[698]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[185]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[580]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[699]

Drug(s) Affected By Osteopontin (SPP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[700]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[121]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[701]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[702]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[431]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[703]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[211]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[698]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[185]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[370]

Drug(s) Affected By Heat shock cognate 71 kDa protein (HSPA8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[414]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[439]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[231]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[443]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[148]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[704]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[219]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[351]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[357]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[705]

Drug(s) Affected By Nidogen-1 (NID1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[265]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[389]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[286]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[365]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[152]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[706]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[173]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[268]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[168]

Drug(s) Affected By Glutathione reductase, mitochondrial (GSR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[707]
Ketoprofen	DMRKXPT	Bursitis		Approved	[142]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[708]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[122]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[123]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[709]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[314]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[710]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[346]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[711]

Drug(s) Affected By Homeobox protein Hox-A1 (HOXA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[712]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[186]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[298]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[713]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[239]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[358]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[252]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[305]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[714]

Drug(s) Affected By Trypsin-3 (PRSS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[286]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[223]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[179]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[172]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[233]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[715]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[237]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[716]

Drug(s) Affected By Melanoma-associated antigen D4 (MAGED4B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[178]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[213]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[253]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[333]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[333]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[610]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[717]

Drug(s) Affected By Opsin-3 (OPN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[386]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[187]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[168]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[188]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[156]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[253]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[185]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[97]

Drug(s) Affected By Interleukin-1 alpha (IL1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[282]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[472]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[472]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[718]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[472]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[170]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[719]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[472]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[354]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]

Drug(s) Affected By Complement factor I (CFI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[327]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[193]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[263]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[172]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[165]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[213]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[181]

Drug(s) Affected By Heat shock-related 70 kDa protein 2 (HSPA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[282]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[720]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[271]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[355]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[297]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[206]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[437]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[186]

Drug(s) Affected By Cytochrome P450 3A5 (CYP3A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[100]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[101]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[106]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[106]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[721]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[722]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[723]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[724]

Drug(s) Affected By Max-interacting protein 1 (MXI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[384]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[364]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[364]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[186]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[364]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[298]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[725]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[187]

Drug(s) Affected By Glycogen debranching enzyme (AGL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[346]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[297]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[263]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[152]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[346]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[213]

Drug(s) Affected By Myosin-10 (MYH10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[726]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[727]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[728]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[729]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[152]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[328]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[213]

Drug(s) Affected By Sal-like protein 1 (SALL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[232]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[186]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[165]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[213]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[237]
Indomethacin	DMSC4A7	Bursitis		Approved	[730]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[98]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[467]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Human Deoxyribonucleic acid (hDNA)	TTUTN1I	NOUNIPROTAC	Modulator	[3]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Multidrug resistance-associated protein 4 (ABCC4)	DTCSGPB	MRP4_HUMAN	Substrate	[4]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Substrate	[5]
Cytochrome P450 2C9 (CYP2C9)	DE5IED8	CP2C9_HUMAN	Substrate	[6]
Mephenytoin 4-hydroxylase (CYP2C19)	DEGTFWK	CP2CJ_HUMAN	Substrate	[7]
Cytochrome P450 2A6 (CYP2A6)	DEJVYAZ	CP2A6_HUMAN	Substrate	[8]
Cytochrome P450 2B6 (CYP2B6) Main DME	DEPKLMQ	CP2B6_HUMAN	Substrate	[9]
Cytochrome P450 2C8 (CYP2C8)	DES5XRU	CP2C8_HUMAN	Substrate	[10]
Cytochrome P450 3A7 (CYP3A7)	DERD86B	CP3A7_HUMAN	Substrate	[11]
Cytochrome P450 2C18 (CYP2C18)	DEZMWRE	CP2CI_HUMAN	Substrate	[8]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
14-3-3 protein sigma (SFN)	OTLJCZ1U	1433S_HUMAN	Gene/Protein Processing	[12]
Actin, cytoplasmic 1 (ACTB)	OT1MCP2F	ACTB_HUMAN	Gene/Protein Processing	[13]
Alanine aminotransferase 2 (GPT2)	OTS5VF7N	ALAT2_HUMAN	Gene/Protein Processing	[14]
Aldehyde dehydrogenase 1A1 (ALDH1A1)	OTCUWZKB	AL1A1_HUMAN	Gene/Protein Processing	[15]
Aldehyde dehydrogenase, dimeric NADP-preferring (ALDH3A1)	OTAYZZE6	AL3A1_HUMAN	Drug Response	[16]
Aldehyde dehydrogenase, mitochondrial (ALDH2)	OTKJ9I3N	ALDH2_HUMAN	Gene/Protein Processing	[15]
Amine oxidase A (MAOA)	OT8NIWMQ	AOFA_HUMAN	Gene/Protein Processing	[15]
Amino acid transporter heavy chain SLC3A2 (SLC3A2)	OTBR33M9	4F2_HUMAN	Gene/Protein Processing	[14]
Angiopoietin-1 (ANGPT1)	OTVZ1NG3	ANGP1_HUMAN	Gene/Protein Processing	[15]
Angiotensin-converting enzyme 2 (ACE2)	OTTRZGU7	ACE2_HUMAN	Gene/Protein Processing	[17]

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