Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM678IB)

• Drug Name: Rapamycin Immunosuppressant Drug Drug Info
• Synonyms: mTOR Inhibitor, Rapamycin

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 21944094
  TTD Drug ID: DM678IB

Molecule-Related Drug Atlas

Drug(s) Targeting FK506-binding protein 1A (FKBP1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GPI-1485	DM64ZYM	Parkinson disease	8A00.0	Phase 2	[11]
SDZ-281-240	DMPZ67G	Pruritus	EC90	Phase 2	[12]
AP1903	DM2LU8M	Transplant rejection	NE84	Phase 1/2	[13]
Gpi-1046	DMD5WK4	Parkinson disease	8A00.0	Terminated	[14]
MYRISTIC ACID	DMYX0BL	Discovery agent	N.A.	Investigative	[14]
Heptyl-Beta-D-Glucopyranoside	DMPQBN0	Discovery agent	N.A.	Investigative	[15]
4-Hydroxy-2-Butanone	DM7BQ65	Discovery agent	N.A.	Investigative	[1]
L-709,587	DM9KCYQ	Discovery agent	N.A.	Investigative	[1]
Methyl Methylsulfinylmethyl Sulfide	DMOCXLW	Discovery agent	N.A.	Investigative	[1]
FKB-001	DM9K834	Discovery agent	N.A.	Investigative	[1]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[16]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[18]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[19]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[20]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[21]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[22]
Bortezomib	DMNO38U	Leukemia		Approved	[23]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[24]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[25]

Drug(s) Affected By Forkhead box protein O3 (FOXO3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[26]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[27]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[30]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[31]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[32]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[33]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[34]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]

Drug(s) Affected By Ribosomal protein S6 kinase beta-1 (RPS6KB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[36]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[37]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[38]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[39]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[40]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[42]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[43]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[44]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[45]

Drug(s) Affected By 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[46]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[47]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[48]
Digoxin	DMQCTIH	Arrhythmia	BC9Z	Approved	[49]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[50]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[51]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[53]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[54]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[55]

Drug(s) Affected By Sterol 26-hydroxylase, mitochondrial (CYP27A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[56]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[54]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[58]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[59]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[60]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[62]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[63]

Drug(s) Affected By NAD-dependent protein deacetylase sirtuin-1 (SIRT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[65]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[66]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[67]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[68]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[69]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[70]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[60]
Olaparib	DM8QB1D	Ovarian cancer	2C73	Approved	[71]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[72]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[73]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[74]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[75]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[49]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[76]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[77]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[78]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[79]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[80]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[81]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[82]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[83]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[84]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[85]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[50]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[86]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[87]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[88]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[89]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[90]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[91]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[92]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[93]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[94]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[95]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[96]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[97]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[99]

Drug(s) Affected By Dihydropyrimidine dehydrogenase (DPYD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[100]
Capecitabine	DMTS85L	Adenocarcinoma	2D40	Approved	[101]
Tegafur	DM31ZQM	Solid tumour/cancer	2A00-2F9Z	Approved	[102]
Flucytosine	DM13VTW	Cryptococcal meningitis		Approved	[49]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[54]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[33]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]

Drug(s) Affected By Nitric oxide synthase 3 (NOS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[49]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[106]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[18]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[107]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[108]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[109]
Fructose	DM43AN2	Vomiting	MD90	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]

Drug(s) Affected By Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[37]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[112]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[113]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[115]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[116]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[117]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[118]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[119]

Drug(s) Affected By Heat shock protein beta-8 (HSPB8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[120]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[121]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[122]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[122]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[21]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[123]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[24]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[124]

Drug(s) Affected By DNA-binding protein inhibitor ID-1 (ID1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[125]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[126]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[128]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[129]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[130]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[131]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[34]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]

Drug(s) Affected By Heat shock 70 kDa protein 1A (HSPA1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[132]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[133]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[134]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[135]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[50]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[136]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[137]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[138]

Drug(s) Affected By Endoplasmic reticulum chaperone BiP (HSPA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[139]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[140]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[136]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[142]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[143]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[144]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[145]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[146]

Drug(s) Affected By Sphingosine 1-phosphate receptor 1 (S1PR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[147]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[131]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[60]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[19]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[148]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[149]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[150]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[151]
GSK618334	DMJPXZ4	Drug abuse	6C4G.1Z	Phase 1	[152]

Drug(s) Affected By Protein EVI2A (EVI2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[153]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[153]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[153]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[153]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[148]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[154]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[155]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[156]

Drug(s) Affected By Proline-rich nuclear receptor coactivator 1 (PNRC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[157]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[128]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[158]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[159]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[153]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[19]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[160]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[161]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[24]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[162]

Drug(s) Affected By N-arachidonyl glycine receptor (GPR18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[163]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[153]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[164]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[164]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[165]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[153]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[153]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[166]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[167]

Drug(s) Affected By Inactive phospholipase C-like protein 1 (PLCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[168]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[153]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[153]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[19]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[169]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[153]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[170]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[35]

Drug(s) Affected By Cyclin-G2 (CCNG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[171]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[153]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[172]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[171]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[158]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[173]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[174]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[174]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[159]

Drug(s) Affected By Kelch-like protein 24 (KLHL24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[157]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[153]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[175]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[158]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[60]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[176]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[177]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[153]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[19]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[178]

Drug(s) Affected By Protein shisa-2 homolog (SHISA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[179]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[153]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[148]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[124]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[124]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[180]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[181]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[182]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[172]

Drug(s) Affected By Protein FAM200C (FAM200C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[173]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[34]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[19]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[184]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[24]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[153]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[185]

Drug(s) Affected By Proto-oncogene FRAT1 (FRAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[186]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[153]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[187]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[35]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[182]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[188]

Drug(s) Affected By F-box only protein 32 (FBXO32)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[133]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[153]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[133]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[173]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[159]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[153]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[189]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[190]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[148]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[191]

Drug(s) Affected By SLAM family member 5 (CD84)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[163]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[153]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[153]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[153]
Epanova	DMHEAGL	Hypertriglyceridemia	5C80.1	Approved	[192]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[193]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[153]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[194]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[195]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[156]

Drug(s) Affected By Krueppel-like factor 2 (KLF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[137]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[196]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[121]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[130]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[197]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[198]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[24]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[124]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[25]

Drug(s) Affected By Dual specificity protein phosphatase 10 (DUSP10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[134]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[199]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[58]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[153]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[58]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[172]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[153]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[200]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[173]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[34]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[76]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[201]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[202]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[203]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[204]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[88]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[204]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[205]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[206]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[207]

Drug(s) Affected By Caspase-8 (CASP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[208]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[209]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[210]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[211]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[212]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[213]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[203]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[214]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[137]

Drug(s) Affected By Cytochrome P450 2A6 (CYP2A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tegafur	DM31ZQM	Solid tumour/cancer	2A00-2F9Z	Approved	[215]
Methoxsalen	DME8FZ9	Cutaneous T-cell lymphoma	2B01	Approved	[216]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[217]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[218]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[187]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[219]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[220]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[221]
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[222]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[223]

Drug(s) Affected By Cytochrome P450 2C9 (CYP2C9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[224]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[225]
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[226]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[227]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[228]
Zafirlukast	DMHNQOG	Asthma	CA23	Approved	[229]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[226]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[230]
Fluconazole	DMOWZ6B	Cryptococcal meningitis		Approved	[227]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[226]

Drug(s) Affected By Cytochrome P450 2B6 (CYP2B6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[231]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[232]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[233]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[234]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[235]
Clopidogrel	DMOL54H	Acute coronary syndrome	BA41	Approved	[236]
Artemisinin	DMOY7W3	Malaria	1F40-1F45	Approved	[237]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[238]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[239]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[240]

Drug(s) Affected By 26S proteasome non-ATPase regulatory subunit 11 (PSMD11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[241]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[128]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[242]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[243]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[20]
Epanova	DMHEAGL	Hypertriglyceridemia	5C80.1	Approved	[192]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[191]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[24]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[244]

Drug(s) Affected By Protein arginine N-methyltransferase 5 (PRMT5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[245]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[163]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[34]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[19]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[20]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[24]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[246]

Drug(s) Affected By Telomerase reverse transcriptase (TERT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[247]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[248]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[249]
Selenium	DM25CGV	N. A.	N. A.	Approved	[250]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[251]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[252]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[253]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[254]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[255]

Drug(s) Affected By Tumor protein p73 (TP73)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[256]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[168]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[86]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[68]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[176]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[198]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[257]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[258]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[86]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[259]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[84]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[260]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[203]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[86]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[65]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[261]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[262]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[263]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[264]

Drug(s) Affected By Bcl-2-like protein 11 (BCL2L11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[265]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[40]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[266]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[163]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[30]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[267]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[172]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[268]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[269]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[60]

Drug(s) Affected By Clustered mitochondria protein homolog (CLUH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[163]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[19]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[20]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[270]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[271]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[246]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[272]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[181]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[272]

Drug(s) Affected By Phospholipid-transporting ATPase ABCA1 (ABCA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[273]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[53]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[54]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[274]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[275]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[276]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[277]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[278]

Drug(s) Affected By Zinc finger protein SNAI1 (SNAI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[279]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[280]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[281]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[282]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[283]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[284]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[34]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[285]
Sanguinarine	DMDINFS	Dental plaque	DA08.4	Approved	[286]

Drug(s) Affected By L-lactate dehydrogenase A chain (LDHA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[270]
Adenosine	DMM2NSK	Paroxysmal supraventricular tachycardia	BC81.Z	Approved	[49]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[136]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[287]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[175]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[158]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[288]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[289]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[290]

Drug(s) Affected By Alpha-1-antitrypsin (SERPINA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[291]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[157]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[163]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[186]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[176]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[19]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[292]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[21]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[293]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[294]
Fructose	DM43AN2	Vomiting	MD90	Approved	[49]
Ketoprofen	DMRKXPT	Bursitis		Approved	[49]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[295]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[79]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[296]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[297]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[298]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[299]

Drug(s) Affected By Interferon gamma (IFNG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[194]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[300]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[301]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[302]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[137]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[303]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[304]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[305]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[306]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[307]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[211]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[308]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[135]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[309]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[310]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[309]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[311]
Selenium	DM25CGV	N. A.	N. A.	Approved	[312]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[313]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[314]

Drug(s) Affected By Estrogen receptor (ESR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[315]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[316]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[317]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[318]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[319]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[320]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[321]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[322]
Procaine	DM4LSNE	Anaesthesia	9A78.6	Approved	[318]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[323]

Drug(s) Affected By Interstitial collagenase (MMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[324]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[325]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[326]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[327]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[113]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[328]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[329]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[330]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[331]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[249]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[332]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[137]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[333]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[334]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[93]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[335]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[336]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[337]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[338]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[339]

Drug(s) Affected By Insulin-like growth factor I (IGF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dantrolene	DM1D8XY	Hyperthermia	MG26	Approved	[340]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[299]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[51]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[341]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[58]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[58]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[158]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[342]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[131]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[343]

Drug(s) Affected By Amyloid-beta precursor protein (APP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[137]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[344]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[345]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[346]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[347]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[348]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[158]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[349]

Drug(s) Affected By Apolipoprotein D (APOD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[350]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[178]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[351]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[352]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[8]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[25]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[350]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[353]

Drug(s) Affected By Protein kinase C gamma type (PRKCG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[16]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[22]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[354]
Bryostatin-1	DM1JOXY	Alzheimer disease	8A20	Phase 2	[355]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[356]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[156]
NSC-1771	DMNXDGQ	Discovery agent	N.A.	Investigative	[357]

Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[358]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[359]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[76]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[126]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[360]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[308]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[299]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[311]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[361]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[358]

Drug(s) Affected By Retinoblastoma-associated protein (RB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[362]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[363]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[364]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[85]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[40]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[365]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[366]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[367]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[368]

Drug(s) Affected By Cyclin-dependent kinase 1 (CDK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[324]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[369]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[259]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[157]
Selenium	DM25CGV	N. A.	N. A.	Approved	[370]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[86]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[371]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[113]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[196]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[368]

Drug(s) Affected By Eukaryotic translation initiation factor 4E (EIF4E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[372]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[373]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[374]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[375]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[376]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[377]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[20]
Momelotinib	DMF98Q0	Myelofibrosis	2A20.2	Approved	[378]
Flurbiprofen	DMGN4BY	Osteoarthritis	FA00-FA05	Approved	[377]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[24]

Drug(s) Affected By Prostate-specific antigen (KLK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[279]
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[379]
Selenium	DM25CGV	N. A.	N. A.	Approved	[380]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[381]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[382]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[383]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[384]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[385]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[386]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[122]

Drug(s) Affected By Insulin-like growth factor 1 receptor (IGF1R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[387]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[388]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[51]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[389]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[390]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[391]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[392]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[122]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[122]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[174]

Drug(s) Affected By 72 kDa type IV collagenase (MMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[325]
Selenium	DM25CGV	N. A.	N. A.	Approved	[393]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[394]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[395]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[396]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[397]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[374]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[398]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[399]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[400]

Drug(s) Affected By Granzyme B (GZMB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[401]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[402]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[307]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[197]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[257]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[403]
Bortezomib	DMNO38U	Leukemia		Approved	[23]
Ethambutol	DMR87LC	Pulmonary tuberculosis	1B10.Z	Approved	[307]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[404]
Pentoxifylline	DMU3DNC	Alcoholic hepatitis	DB94.1	Approved	[49]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[405]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[406]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[407]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[126]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[408]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[308]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[309]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[310]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[409]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[309]

Drug(s) Affected By Androgen receptor (AR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[410]
Nilutamide	DMFN07X	Prostate cancer	2C82.0	Approved	[410]
Hydroxyflutamide	DMGIZF5	Prostate cancer	2C82.0	Approved	[410]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[411]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[412]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[413]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[414]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[415]
Selenium	DM25CGV	N. A.	N. A.	Approved	[380]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[416]

Drug(s) Affected By Integrin alpha-M (ITGAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[417]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[43]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[418]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[419]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[420]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[421]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[178]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[422]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[423]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[424]

Drug(s) Affected By Cyclin-dependent kinase 4 (CDK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[425]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[426]
Selenium	DM25CGV	N. A.	N. A.	Approved	[370]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[427]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[113]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[428]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[429]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[368]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[345]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[163]

Drug(s) Affected By Polyadenylate-binding protein 1 (PABPC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[131]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[20]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[270]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[157]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[271]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[181]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[430]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[17]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[431]

Drug(s) Affected By Proliferating cell nuclear antigen (PCNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[76]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[432]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[16]
Selenium	DM25CGV	N. A.	N. A.	Approved	[370]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[51]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[245]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[433]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[113]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[196]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[434]

Drug(s) Affected By High affinity immunoglobulin gamma Fc receptor I (FCGR1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[163]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[435]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[194]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[187]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[43]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[156]
Maleic Acid	DM4L0R7	Discovery agent	N.A.	Investigative	[436]
PHENCYCLIDINE	DMQBEYX	Discovery agent	N.A.	Investigative	[437]
paraquat	DMR8O3X	Discovery agent	N.A.	Investigative	[438]

Drug(s) Affected By Cadherin-1 (CDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[439]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[280]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[440]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[441]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[320]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[442]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[175]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[443]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[172]

Drug(s) Affected By Elongation factor 2 (EEF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[444]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[289]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[20]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[445]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[446]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[181]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[447]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[448]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[447]

Drug(s) Affected By Perforin-1 (PRF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[401]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[177]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[257]
Bortezomib	DMNO38U	Leukemia		Approved	[23]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[449]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[354]
Pentoxifylline	DMU3DNC	Alcoholic hepatitis	DB94.1	Approved	[49]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[450]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[451]

Drug(s) Affected By Pyruvate kinase PKM (PKM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[452]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[434]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[242]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[172]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[453]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[454]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[289]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[290]

Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[455]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[279]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[297]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[299]
Selenium	DM25CGV	N. A.	N. A.	Approved	[393]
Pentosan Polysulfate	DM2HRKE	Interstitial cystitis	GC00.3	Approved	[456]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[205]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[457]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[458]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[459]

Drug(s) Affected By Histone H2AX (H2AX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[460]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[461]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[462]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[463]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[464]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[465]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[466]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[467]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[468]

Drug(s) Affected By Platelet glycoprotein 4 (CD36)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[140]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[469]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[163]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[470]
Tolcapone	DM8MNVO	Parkinson disease	8A00.0	Approved	[471]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[472]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[159]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[420]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[221]
Asasantin	DMCZIHT	Cerebrovascular ischaemia	8B1Z	Approved	[473]

Drug(s) Affected By Gap junction alpha-1 protein (GJA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[474]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[249]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[175]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[475]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[476]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[477]
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[474]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[478]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[479]

Drug(s) Affected By Transcription factor EB (TFEB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[480]
Prochlorperazine	DM53SRA	Nausea	MD90	Approved	[480]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[117]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[481]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[176]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[19]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[482]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[270]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[150]

Drug(s) Affected By Cyclin-A2 (CCNA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[483]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[369]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[432]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[50]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[245]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[365]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[484]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[196]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[485]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]

Drug(s) Affected By Macrophage scavenger receptor types I and II (MSR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[158]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[187]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[486]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[487]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[488]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[156]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[168]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[178]

Drug(s) Affected By Interleukin-10 (IL10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[489]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[300]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[490]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[199]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[491]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[492]
Bisoprolol	DM3UZ95	Hypertension	BA00-BA04	Approved	[493]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[305]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[494]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[495]

Drug(s) Affected By Eukaryotic translation initiation factor 4B (EIF4B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[43]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[496]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[376]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[19]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[20]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[497]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[157]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[246]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[181]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[43]

Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[498]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[499]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[80]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[316]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[500]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[85]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[501]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[502]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[503]

Drug(s) Affected By G1/S-specific cyclin-E1 (CCNE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[76]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[504]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[245]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[88]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[365]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[505]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[506]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[507]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[508]

Drug(s) Affected By Cyclin-dependent kinase 2 (CDK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[324]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[369]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[504]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[509]
Selenium	DM25CGV	N. A.	N. A.	Approved	[370]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[88]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[510]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[457]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[428]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[368]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[511]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[512]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[513]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[79]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[514]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[515]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[516]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[517]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[518]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]

Drug(s) Affected By ATP-binding cassette sub-family D member 3 (ABCD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[137]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[163]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[122]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[122]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[34]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[19]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[20]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[148]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[519]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[512]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[520]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[521]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[522]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[511]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[49]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[211]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[79]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[514]

Drug(s) Affected By G1/S-specific cyclin-D2 (CCND2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[16]
Selenium	DM25CGV	N. A.	N. A.	Approved	[370]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[113]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[368]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[523]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[524]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[81]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[288]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[176]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[19]

Drug(s) Affected By G1/S-specific cyclin-D3 (CCND3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[324]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[500]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[368]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[525]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[526]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[524]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[527]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[158]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[528]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[131]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[529]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[530]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[337]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[80]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[531]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[39]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[532]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[51]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[502]

Drug(s) Affected By Macrosialin (CD68)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[211]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[16]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[533]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[163]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[122]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[122]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[534]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[534]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[21]

Drug(s) Affected By Insulin receptor substrate 1 (IRS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[432]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[175]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[158]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[130]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[535]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[173]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[34]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[19]

Drug(s) Affected By Metalloproteinase inhibitor 3 (TIMP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[393]
Pentosan Polysulfate	DM2HRKE	Interstitial cystitis	GC00.3	Approved	[456]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[113]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[330]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[374]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[268]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[173]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[34]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]

Drug(s) Affected By Myosin-11 (MYH11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[536]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[60]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[537]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[177]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[190]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[191]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[124]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[124]
Nifedipine	DMSVOZT	Angina pectoris	BA40	Approved	[538]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[271]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma (PPARG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[539]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[540]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[541]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[542]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[543]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[544]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[545]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[546]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[547]

Drug(s) Affected By Signal transducer and activator of transcription 3 (STAT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[49]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[211]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[548]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[549]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[550]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[551]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[18]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[552]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[553]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[554]

Drug(s) Affected By Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[211]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[157]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[163]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[158]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[555]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[173]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[556]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[557]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]

Drug(s) Affected By Serine/threonine-protein kinase mTOR (MTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[558]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[559]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[37]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[38]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[112]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[502]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[560]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[561]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[186]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[119]

Drug(s) Affected By Proliferation marker protein Ki-67 (MKI67)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[562]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[484]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[241]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[345]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[563]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[30]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[527]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[564]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[565]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[131]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[363]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[500]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[87]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[566]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[567]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[319]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[568]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[505]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[569]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[570]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 6 (FASLG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[168]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[212]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[571]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[572]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[573]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[138]
Fructose	DM43AN2	Vomiting	MD90	Approved	[574]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[575]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[576]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[577]

Drug(s) Affected By Glycogen synthase kinase-3 beta (GSK3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[139]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[364]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[578]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[579]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[580]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[581]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[582]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[163]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[583]

Drug(s) Affected By Hexokinase-2 (HK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[157]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[434]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[175]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[584]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[585]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[34]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[586]

Drug(s) Affected By Interleukin-2 (IL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sirolimus	DMGW1ID	Advanced cancer	2A00-2F9Z	Approved	[49]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[587]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[490]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[588]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[589]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[590]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[591]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[592]
Fentanyl	DM8WAHT	Analgesia	MB40.8	Approved	[593]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[594]

Drug(s) Affected By Small ribosomal subunit protein uS10 (RPS20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[20]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[257]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[272]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[353]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[156]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[430]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[595]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[172]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[596]

Drug(s) Affected By Small ribosomal subunit protein eS6 (RPS6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[597]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[18]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[598]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[44]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[599]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[600]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[601]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[481]
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[529]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]

Drug(s) Affected By Large ribosomal subunit protein eL32 (RPL32)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[602]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[603]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[20]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[271]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[272]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[431]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[604]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[166]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[605]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[596]

Drug(s) Affected By Eukaryotic translation initiation factor 4 gamma 2 (EIF4G2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[606]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[606]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[606]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[182]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[20]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[257]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[607]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[608]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[157]

Drug(s) Affected By Oxidized low-density lipoprotein receptor 1 (OLR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[439]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[439]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[609]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[173]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[610]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[611]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[612]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[439]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[439]
Nifedipine	DMSVOZT	Angina pectoris	BA40	Approved	[613]

Drug(s) Affected By Protein jagged-1 (JAG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[157]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[120]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[242]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[614]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[34]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[172]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[615]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[190]

Drug(s) Affected By Heat shock factor protein 1 (HSF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[616]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[617]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[617]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[618]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[619]
Ceftazidime	DM41GRA	Bacteremia	1A73	Approved	[617]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[163]
Chlorpheniramine	DM5URA2	Allergic rhinitis	CA08.0	Approved	[617]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[617]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[617]

Drug(s) Affected By E3 ubiquitin-protein ligase Mdm2 (MDM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[211]
Flucytosine	DM13VTW	Cryptococcal meningitis		Approved	[620]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[620]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[602]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[113]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[621]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[333]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[31]
Amifostine	DM5FL14	Mucositis	CA00	Approved	[622]

Drug(s) Affected By RNA-binding protein EWS (EWSR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[157]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[599]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[534]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[534]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[150]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[20]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[623]
Romidepsin	DMT5GNL	Cutaneous T-cell lymphoma	2B01	Approved	[624]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[625]

Drug(s) Affected By Protein kinase C delta type (PRKCD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[175]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[31]
Butorphanol	DM5KYPJ	Pain	MG30-MG3Z	Approved	[626]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[627]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[628]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[629]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[131]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[182]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[630]

Drug(s) Affected By Caldesmon (CALD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[631]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[374]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[632]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[178]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[20]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[623]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[148]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[633]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[72]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[99]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[76]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[77]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[439]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[634]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[85]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[433]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[88]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[337]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[635]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[203]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[636]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[113]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[620]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[637]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[581]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[138]

Drug(s) Affected By Forkhead box protein O1 (FOXO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[39]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[638]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[241]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[163]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[172]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[496]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[34]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]

Drug(s) Affected By Oxysterols receptor LXR-alpha (NR1H3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[128]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[221]
Gemfibrozil	DMD8Q3J	Hyperlipidaemia	5C80	Approved	[639]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[640]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[639]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[641]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[642]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[148]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[643]

Drug(s) Affected By S-phase kinase-associated protein 2 (SKP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[76]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[484]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[644]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[43]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[645]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[122]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[122]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[34]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]

Drug(s) Affected By Sequestosome-1 (SQSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[559]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[37]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[646]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[452]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[647]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[65]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[113]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[345]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[242]

Drug(s) Affected By Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[648]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[502]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[429]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[373]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[649]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[130]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[601]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[376]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[650]

Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein D0 (HNRNPD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[651]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[157]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[159]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[290]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[189]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[178]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[20]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[623]

Drug(s) Affected By Lysosome membrane protein 2 (SCARB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[163]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[34]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[176]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[20]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[612]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[148]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[124]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[270]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[652]

Drug(s) Affected By Kelch-like ECH-associated protein 1 (KEAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[653]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[654]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[242]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[655]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[174]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[174]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[174]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[290]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[656]

Drug(s) Affected By Beclin-1 (BECN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[657]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[76]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[112]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[113]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[658]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[659]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[660]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[661]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[662]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[481]

Drug(s) Affected By Transcription factor HES-1 (HES1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[663]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[163]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[158]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[60]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[122]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[34]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[176]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]

Drug(s) Affected By Ribosomal protein S6 kinase alpha-1 (RPS6KA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[82]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[163]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[122]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[122]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[159]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[20]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[148]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[22]

Drug(s) Affected By Hypoxia-inducible factor 1-alpha (HIF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[664]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[665]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[666]
Triamterene	DM2HU9I	Congestive heart failure	BD10	Approved	[666]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[667]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[668]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[434]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[390]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[53]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[42]

Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[669]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[50]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[670]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[671]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[672]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[673]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[674]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[675]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[651]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[126]

Drug(s) Affected By Programmed cell death protein 4 (PDCD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[676]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[157]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[677]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[676]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[31]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[158]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[678]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[130]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[676]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[60]

Drug(s) Affected By CREB-regulated transcription coactivator 2 (CRTC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[163]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[159]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[24]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[270]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[181]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[679]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[170]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[430]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[430]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[680]

Drug(s) Affected By Rapamycin-insensitive companion of mTOR (RICTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[654]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[241]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[159]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[681]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[270]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[654]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[246]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[682]

Drug(s) Affected By NACHT, LRR and PYD domains-containing protein 3 (NLRP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[211]
Selenium	DM25CGV	N. A.	N. A.	Approved	[312]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[163]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[683]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[655]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[60]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[684]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[685]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[686]
Atropine	DMEN6X7	Organophosphate poisoning	NE6Z	Approved	[687]

Drug(s) Affected By Autophagy protein 5 (ATG5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[38]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[117]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[118]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[662]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[688]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[689]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[159]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[72]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[150]

Drug(s) Affected By Forkhead box protein P1 (FOXP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[690]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[34]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[189]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[178]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[691]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[24]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[25]

Drug(s) Affected By Tumor protein 63 (TP63)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[168]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[692]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[693]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[694]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[695]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[696]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[24]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[697]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[25]

Drug(s) Affected By Ribosomal protein S6 kinase beta-2 (RPS6KB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[20]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[148]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[156]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[241]
Myricetin	DMTV4L0	Discovery agent	N.A.	Investigative	[698]

Drug(s) Affected By La-related protein 1 (LARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[241]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[131]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[20]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[270]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[246]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[272]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[181]
G1	DMTV42K	Lymphoma	2A80-2A86	Phase 1/2	[699]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[700]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[156]

Drug(s) Affected By Protein PML (PML)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[371]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[701]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[563]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[701]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[20]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[257]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[702]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[702]

Drug(s) Affected By Protein kinase C eta type (PRKCH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[157]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[703]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[172]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[158]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[131]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[19]
Indomethacin	DMSC4A7	Bursitis		Approved	[704]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[181]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[172]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[354]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[705]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[706]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[707]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[708]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[709]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[710]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[711]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[712]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[713]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[711]

Drug(s) Affected By Neural cell adhesion molecule L1 (L1CAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[279]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[292]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[172]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[292]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[20]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[714]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[25]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[185]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[715]

Drug(s) Affected By Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[337]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[168]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[716]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[137]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[717]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[175]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[718]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[719]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[60]

Drug(s) Affected By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[720]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[224]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[721]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[227]
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[226]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[226]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[722]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[723]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[724]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[725]

Drug(s) Affected By Glutathione S-transferase theta-1 (GSTT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[726]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[54]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[158]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[19]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[727]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[271]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[187]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[728]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[272]

Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[49]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[559]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[401]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[729]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[587]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[730]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[731]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[732]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[137]

Drug(s) Affected By Linker for activation of T-cells family member 2 (LAT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[175]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[609]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[122]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[122]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[148]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[24]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[733]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[451]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[734]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
FK506-binding protein 1A (FKBP1A)	TTMW94E	FKB1A_HUMAN	Inhibitor	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
26S proteasome non-ATPase regulatory subunit 11 (PSMD11)	OT8KO67V	PSD11_HUMAN	Gene/Protein Processing	[2]
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)	OTRT3F3U	HMDH_HUMAN	Gene/Protein Processing	[3]
72 kDa type IV collagenase (MMP2)	OT5NIWA2	MMP2_HUMAN	Gene/Protein Processing	[4]
Alpha-1-antitrypsin (SERPINA1)	OTACYW9J	A1AT_HUMAN	Protein Interaction/Cellular Processes	[5]
Amyloid-beta precursor protein (APP)	OTKFD7R4	A4_HUMAN	Gene/Protein Processing	[6]
Androgen receptor (AR)	OTUBKAZZ	ANDR_HUMAN	Gene/Protein Processing	[7]
Apolipoprotein D (APOD)	OTT77XW8	APOD_HUMAN	Protein Interaction/Cellular Processes	[8]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Gene/Protein Processing	[2]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[9]
ATP-binding cassette sub-family D member 3 (ABCD3)	OT2PITLX	ABCD3_HUMAN	Gene/Protein Processing	[10]

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