Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM678IB)

• Drug Name: Rapamycin Immunosuppressant Drug Drug Info
• Synonyms: mTOR Inhibitor, Rapamycin

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 21944094
  TTD Drug ID: DM678IB

Molecule-Related Drug Atlas

Drug(s) Targeting FK506-binding protein 1A (FKBP1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GPI-1485	DM64ZYM	Parkinson disease	8A00.0	Phase 2	[11]
SDZ-281-240	DMPZ67G	Pruritus	EC90	Phase 2	[12]
AP1903	DM2LU8M	Transplant rejection	NE84	Phase 1/2	[13]
Gpi-1046	DMD5WK4	Parkinson disease	8A00.0	Terminated	[14]
MYRISTIC ACID	DMYX0BL	Discovery agent	N.A.	Investigative	[14]
Heptyl-Beta-D-Glucopyranoside	DMPQBN0	Discovery agent	N.A.	Investigative	[15]
4-Hydroxy-2-Butanone	DM7BQ65	Discovery agent	N.A.	Investigative	[1]
L-709,587	DM9KCYQ	Discovery agent	N.A.	Investigative	[1]
Methyl Methylsulfinylmethyl Sulfide	DMOCXLW	Discovery agent	N.A.	Investigative	[1]
FKB-001	DM9K834	Discovery agent	N.A.	Investigative	[1]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[16]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[18]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[19]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[20]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[21]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[22]
Bortezomib	DMNO38U	Leukemia		Approved	[23]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[24]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[25]

Drug(s) Affected By Forkhead box protein O3 (FOXO3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[26]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[27]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[30]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[31]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[32]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[33]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[34]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]

Drug(s) Affected By Sterol 26-hydroxylase, mitochondrial (CYP27A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[36]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[38]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[39]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[40]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[41]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[43]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[44]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[45]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[46]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[47]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[48]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[49]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[50]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[51]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[52]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[53]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[54]

Drug(s) Affected By Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[55]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[60]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[61]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[62]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[63]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[64]

Drug(s) Affected By DNA-binding protein inhibitor ID-1 (ID1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[65]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[66]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[68]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[69]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[70]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[71]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[34]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]

Drug(s) Affected By Protein EVI2A (EVI2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[72]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[72]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[42]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[72]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[73]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[74]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[75]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[76]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[77]

Drug(s) Affected By Proline-rich nuclear receptor coactivator 1 (PNRC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[68]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[72]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[19]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[81]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[82]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[24]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[83]

Drug(s) Affected By Inactive phospholipase C-like protein 1 (PLCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[84]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[72]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[72]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[19]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[85]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[72]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[86]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[35]

Drug(s) Affected By Cyclin-G2 (CCNG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[87]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[72]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[88]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[87]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[79]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[89]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[90]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]

Drug(s) Affected By Kelch-like protein 24 (KLHL24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[79]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[93]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[72]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[19]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[94]

Drug(s) Affected By Protein shisa-2 homolog (SHISA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[95]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[72]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[73]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[74]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[96]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[96]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[97]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[99]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[88]

Drug(s) Affected By Protein FAM200C (FAM200C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[100]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[89]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[34]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[19]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[101]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[24]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[72]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[102]

Drug(s) Affected By Proto-oncogene FRAT1 (FRAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[72]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[73]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[104]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[35]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[99]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[105]

Drug(s) Affected By F-box only protein 32 (FBXO32)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[106]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[72]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[106]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[89]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[72]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[107]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[108]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[74]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[109]

Drug(s) Affected By SLAM family member 5 (CD84)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[72]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[72]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[72]
Epanova	DMHEAGL	Hypertriglyceridemia	5C80.1	Approved	[111]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[112]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[72]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[113]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[114]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[77]

Drug(s) Affected By Krueppel-like factor 2 (KLF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[115]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[116]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[117]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[70]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[118]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[24]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[96]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[25]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[120]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[121]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[122]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[123]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[124]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[53]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[124]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[125]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[126]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[127]

Drug(s) Affected By 26S proteasome non-ATPase regulatory subunit 11 (PSMD11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[68]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[129]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[20]
Epanova	DMHEAGL	Hypertriglyceridemia	5C80.1	Approved	[111]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[109]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[24]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[131]

Drug(s) Affected By Tumor protein p73 (TP73)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[132]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[84]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[51]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[134]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[135]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[51]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[136]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[48]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[123]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[51]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[138]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[139]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[140]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[141]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[142]

Drug(s) Affected By Bcl-2-like protein 11 (BCL2L11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[144]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[145]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[30]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[146]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[88]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[147]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[148]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[41]

Drug(s) Affected By Clustered mitochondria protein homolog (CLUH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[19]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[20]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[149]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[150]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[151]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[152]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[152]

Drug(s) Affected By Phospholipid-transporting ATPase ABCA1 (ABCA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[153]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[154]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[38]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[155]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[156]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[157]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[158]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[159]

Drug(s) Affected By Zinc finger protein SNAI1 (SNAI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[160]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[161]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[162]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[163]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[164]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[165]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[34]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[166]
Sanguinarine	DMDINFS	Dental plaque	DA08.4	Approved	[167]

Drug(s) Affected By Interstitial collagenase (MMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[168]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[169]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[170]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[171]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[172]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[173]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[174]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[175]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[176]

Drug(s) Affected By Amyloid-beta precursor protein (APP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[115]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[177]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[178]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[179]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[181]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[79]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[182]

Drug(s) Affected By Apolipoprotein D (APOD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[183]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[73]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[94]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[184]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[185]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[4]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[25]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[183]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[186]

Drug(s) Affected By Retinoblastoma-associated protein (RB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[187]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[188]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[189]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[49]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[144]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[190]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[191]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[192]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[193]

Drug(s) Affected By Eukaryotic translation initiation factor 4E (EIF4E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[194]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[195]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[196]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[197]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[198]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[199]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[20]
Momelotinib	DMF98Q0	Myelofibrosis	2A20.2	Approved	[200]
Flurbiprofen	DMGN4BY	Osteoarthritis	FA00-FA05	Approved	[199]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[24]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[201]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[202]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[203]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[66]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[204]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[205]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[206]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[207]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[208]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[206]

Drug(s) Affected By High affinity immunoglobulin gamma Fc receptor I (FCGR1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[209]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[73]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[113]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[104]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[210]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[77]
Maleic Acid	DM4L0R7	Discovery agent	N.A.	Investigative	[211]
PHENCYCLIDINE	DMQBEYX	Discovery agent	N.A.	Investigative	[212]
paraquat	DMR8O3X	Discovery agent	N.A.	Investigative	[213]

Drug(s) Affected By Cadherin-1 (CDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[214]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[161]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[215]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[216]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[217]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[218]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[219]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[88]

Drug(s) Affected By Elongation factor 2 (EEF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[220]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[221]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[73]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[20]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[222]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[223]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[224]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[225]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[224]

Drug(s) Affected By Perforin-1 (PRF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[226]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[73]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[134]
Bortezomib	DMNO38U	Leukemia		Approved	[23]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[227]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[228]
Pentoxifylline	DMU3DNC	Alcoholic hepatitis	DB94.1	Approved	[229]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[230]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[231]

Drug(s) Affected By Histone H2AX (H2AX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[232]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[233]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[234]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[235]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[236]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[237]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[238]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[239]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[240]

Drug(s) Affected By Transcription factor EB (TFEB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[241]
Prochlorperazine	DM53SRA	Nausea	MD90	Approved	[241]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[62]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[242]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[19]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[243]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[149]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[244]

Drug(s) Affected By Macrophage scavenger receptor types I and II (MSR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[79]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[73]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[104]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[245]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[246]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[247]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[77]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[84]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[94]

Drug(s) Affected By Eukaryotic translation initiation factor 4B (EIF4B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[210]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[248]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[198]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[19]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[20]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[249]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[78]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[151]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[210]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[250]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[251]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[252]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[253]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[254]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[255]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[256]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[257]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[258]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[259]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[260]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[251]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[261]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[262]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[263]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[250]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[229]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[264]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[253]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[254]

Drug(s) Affected By G1/S-specific cyclin-D2 (CCND2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[16]
Selenium	DM25CGV	N. A.	N. A.	Approved	[265]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[193]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[266]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[267]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[45]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[268]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[19]

Drug(s) Affected By G1/S-specific cyclin-D3 (CCND3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[168]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[269]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[193]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[270]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[271]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[267]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[272]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[79]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[273]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[71]

Drug(s) Affected By Macrosialin (CD68)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[264]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[16]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[274]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[275]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[275]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[276]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[276]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[21]

Drug(s) Affected By Metalloproteinase inhibitor 3 (TIMP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[277]
Pentosan Polysulfate	DM2HRKE	Interstitial cystitis	GC00.3	Approved	[278]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[174]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[100]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[196]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[147]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[89]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[34]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]

Drug(s) Affected By Myosin-11 (MYH11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[279]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[280]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[93]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[108]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[109]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[96]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[96]
Nifedipine	DMSVOZT	Angina pectoris	BA40	Approved	[281]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[150]

Drug(s) Affected By Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[264]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[79]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[282]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[89]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[283]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[284]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[73]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[188]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[269]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[52]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[285]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[286]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[287]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[288]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[289]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[290]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[291]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 6 (FASLG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[84]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[292]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[293]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[294]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[295]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[296]
Fructose	DM43AN2	Vomiting	MD90	Approved	[297]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[298]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[299]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[300]

Drug(s) Affected By Small ribosomal subunit protein uS10 (RPS20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[20]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[134]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[152]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[186]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[77]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[301]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[302]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[88]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[303]

Drug(s) Affected By Small ribosomal subunit protein eS6 (RPS6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[304]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[18]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[305]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[306]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[307]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[308]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[309]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[242]
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[310]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]

Drug(s) Affected By Large ribosomal subunit protein eL32 (RPL32)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[311]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[312]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[20]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[150]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[152]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[313]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[314]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[315]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[316]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[303]

Drug(s) Affected By Eukaryotic translation initiation factor 4 gamma 2 (EIF4G2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[317]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[317]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[317]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[20]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[134]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[318]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[319]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[78]

Drug(s) Affected By Oxidized low-density lipoprotein receptor 1 (OLR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[214]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[320]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[89]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[321]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[322]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[323]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[214]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[214]
Nifedipine	DMSVOZT	Angina pectoris	BA40	Approved	[324]

Drug(s) Affected By Protein jagged-1 (JAG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[325]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[326]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[34]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[327]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[108]

Drug(s) Affected By Heat shock factor protein 1 (HSF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[328]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[329]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[329]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[330]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[331]
Ceftazidime	DM41GRA	Bacteremia	1A73	Approved	[329]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Chlorpheniramine	DM5URA2	Allergic rhinitis	CA08.0	Approved	[329]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[329]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[329]

Drug(s) Affected By RNA-binding protein EWS (EWSR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[307]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[276]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[276]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[244]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[20]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[332]
Romidepsin	DMT5GNL	Cutaneous T-cell lymphoma	2B01	Approved	[333]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[334]

Drug(s) Affected By Caldesmon (CALD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[335]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[196]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[336]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[73]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[94]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[20]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[332]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[74]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[337]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[338]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[339]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[123]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[340]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[341]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[342]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[343]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[296]

Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein D0 (HNRNPD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[344]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[345]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[107]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[94]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[20]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[332]

Drug(s) Affected By Lysosome membrane protein 2 (SCARB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[34]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[73]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[20]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[323]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[74]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[96]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[149]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[346]

Drug(s) Affected By Kelch-like ECH-associated protein 1 (KEAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[347]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[348]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[129]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[349]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[90]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[345]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[350]

Drug(s) Affected By Transcription factor HES-1 (HES1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[351]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[79]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[41]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[275]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[34]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[73]

Drug(s) Affected By Programmed cell death protein 4 (PDCD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[352]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[353]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[352]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[31]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[79]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[354]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[70]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[352]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[41]

Drug(s) Affected By Rapamycin-insensitive companion of mTOR (RICTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[348]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[100]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[355]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[73]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[149]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[348]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[151]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[356]

Drug(s) Affected By NACHT, LRR and PYD domains-containing protein 3 (NLRP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[264]
Selenium	DM25CGV	N. A.	N. A.	Approved	[357]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[358]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[349]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[41]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[359]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[360]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[361]
Atropine	DMEN6X7	Organophosphate poisoning	NE6Z	Approved	[362]

Drug(s) Affected By Autophagy protein 5 (ATG5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[363]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[62]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[63]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[364]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[365]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[366]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[367]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[244]

Drug(s) Affected By Tumor protein 63 (TP63)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[84]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[368]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[369]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[370]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[371]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[372]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[24]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[373]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[25]

Drug(s) Affected By Protein PML (PML)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[374]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[375]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[376]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[375]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[73]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[20]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[134]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[377]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[377]

Drug(s) Affected By Protein kinase C eta type (PRKCH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[378]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[88]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[79]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[19]
Indomethacin	DMSC4A7	Bursitis		Approved	[379]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[88]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[228]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[380]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[381]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[382]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[383]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[384]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[385]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[386]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[387]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[388]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[386]

Drug(s) Affected By Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[338]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[84]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[389]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[115]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[390]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[391]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[392]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[41]

Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[393]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[229]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[394]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[226]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[395]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[396]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[397]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[398]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[399]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[115]

Drug(s) Affected By Linker for activation of T-cells family member 2 (LAT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[320]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[275]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[275]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[73]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[74]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[24]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[400]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[231]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[401]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
FK506-binding protein 1A (FKBP1A)	TTMW94E	FKB1A_HUMAN	Inhibitor	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
26S proteasome non-ATPase regulatory subunit 11 (PSMD11)	OT8KO67V	PSD11_HUMAN	Gene/Protein Processing	[2]
Amyloid-beta precursor protein (APP)	OTKFD7R4	A4_HUMAN	Gene/Protein Processing	[3]
Apolipoprotein D (APOD)	OTT77XW8	APOD_HUMAN	Protein Interaction/Cellular Processes	[4]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Regulation of Drug Effects	[5]
Autophagy protein 5 (ATG5)	OT4T5SMS	ATG5_HUMAN	Gene/Protein Processing	[6]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Gene/Protein Processing	[7]
Bcl-2-like protein 1 (BCL2L1)	OTRC5K9O	B2CL1_HUMAN	Gene/Protein Processing	[2]
Bcl-2-like protein 11 (BCL2L11)	OTNQQWFJ	B2L11_HUMAN	Gene/Protein Processing	[8]
Cadherin-1 (CDH1)	OTFJMXPM	CADH1_HUMAN	Gene/Protein Processing	[9]
Caldesmon (CALD1)	OTNJKJ6Q	CALD1_HUMAN	Gene/Protein Processing	[10]

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