Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM7RJXL)

Drug Name
Imatinib Drug Info
Synonyms
Cgp 57148; Glamox; Glamox (TN); Gleevec (TN); Glivec (TN); Imatinib (INN); Imatinib (STI571); Imatinib Methansulfonate; Imatinib [INN:BAN]; 112GI019; 152459-95-5; BKJ8M8G5HI; CCRIS 9076; CGP-57148; CHEMBL941; Imatinib free base; STI; UNII-BKJ8M8G5HI
Indication
Disease Entry ICD 11 Status REF
Acute lymphoblastic leukaemia 2A85 Approved [1]
Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [2]
Choroidal neovascularization 9B76 Approved [2]
Chronic eosinophilic leukemia Approved [2]
Chronic myelogenous leukaemia 2A20.0 Approved [3]
Chronic myeloid leukaemia 2A20 Approved [4]
Dermatofibrosarcoma protuberans Approved [2]
Gastrointestinal stromal tumour 2B5B Approved [2]
Leukemia Approved [2]
Malignant peripheral nerve sheath tumor Approved [2]
Myeloproliferative neoplasm 2A20 Approved [2]
Pulmonary hypertension BB01 Approved [2]
Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 3 [5]
Intestinal cancer 2C0Z Phase 3 [3]
Lung cancer 2C25.0 Phase 2 [3]
Idiopathic hypereosinophilic syndrome Investigative [2]
Middle East Respiratory Syndrome (MERS) 1D64 Investigative [6]
Scleroderma 4A42 Investigative [2]
Severe acute respiratory syndrome (SARS) 1D65 Investigative [6]
Systemic mastocytosis 2A21.0 Investigative [7]
Therapeutic Class
Anticancer Agents
Cross-matching ID
PubChem CID
5291
ChEBI ID
CHEBI:45783
CAS Number
CAS 152459-95-5
TTD Drug ID
DM7RJXL
VARIDT Drug ID
DR00032
INTEDE Drug ID
DR0858
ACDINA Drug ID
D00324

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Preclinical Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Fusion protein Bcr-Abl (Bcr-Abl)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [8]
Nilotinib DM7HXWT Chronic myelogenous leukaemia 2A20.0 Approved [30]
Asciminib DM7EVUF Chronic myeloid leukaemia 2A20 Approved [31]
Radotinib DMWA74Y leukaemia 2A60-2B33 Phase 3 [32]
ABL 001 DMMF5K4 Chronic myeloid leukaemia 2A20 Phase 3 [33]
ICLUSIG DM1SQSE Acute lymphoblastic leukaemia 2A85 Phase 3 [34]
Bafetinib DM7586F Bone disease FC0Z Phase 2 [35]
AN-019 DMJ7QP8 Chronic myelogenous leukaemia 2A20.0 Phase 2 [36]
HQP1351 DMQ30X2 Chronic myeloid leukaemia 2A20 Phase 2 [37]
NPB-001-056 DM78KMT Chronic myelogenous leukaemia 2A20.0 Phase 1/2 [38]
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Drug(s) Targeting Platelet-derived growth factor receptor (PDGFR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Pazopanib HCl DM6U9CQ Renal cell carcinoma 2C90 Approved [39]
Intedanib DMSTA36 Colorectal cancer 2B91.Z Approved [40]
CT-102 DMB8PF3 Diabetic foot ulcer BD54 Approved [41]
Trapidil DMY67U8 Acute coronary syndrome BA41 Phase 4 [42]
TKI258 DMYLT67 Renal cell carcinoma 2C90 Phase 3 [8]
BAY-57-9352 DMVA5NS Gastric adenocarcinoma 2B72 Phase 2 [8]
X-82 DMW1NKO Age-related macular degeneration 9B75.0 Phase 2 [43]
Vorolanib DMIM1U9 Non-small-cell lung cancer 2C25 Phase 2 [44]
PMID25623274-Compound-WO2014132220C2 DMXEZWP Pulmonary arterial hypertension BB01.0 Patented [45]
PMID25623274-Compound-WO2014132220C1 DMA2IMQ Pulmonary arterial hypertension BB01.0 Patented [45]
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Drug(s) Targeting Tyrosine-protein kinase Kit (KIT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [46]
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [47]
Regorafenib DMHSY1I Gastrointestinal stromal tumour 2B5B Approved [1]
Ponatinib DMYGJQO Acute lymphoblastic leukaemia 2A85 Approved [1]
Pazopanib HCl DM6U9CQ Renal cell carcinoma 2C90 Approved [39]
Pexidartinib DMS2J0Z Tenosynovial giant cell tumour 2F7B Approved [48]
Ripretinib DM958QB Gastrointestinal stromal tumour 2B5B Approved [49]
Famitinib DMSFWT7 Solid tumour/cancer 2A00-2F9Z Phase 2 [50]
XL-820 DMMHX9K Solid tumour/cancer 2A00-2F9Z Phase 2 [51]
MP470 DMELUAK Solid tumour/cancer 2A00-2F9Z Phase 2 [52]
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Drug(s) Targeting HUMAN fusion protein Bcr-Abl (Bcr-Abl)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [6]
Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [53]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [54]
Methotrexate DM2TEOL Anterior urethra cancer Approved [55]
Folic Acid DMEMBJC Colorectal carcinoma Approved [56]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [55]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [55]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [57]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [55]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [58]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [59]
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Drug(s) Transported By Breast cancer resistance protein (ABCG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [60]
Methotrexate DM2TEOL Anterior urethra cancer Approved [61]
Folic Acid DMEMBJC Colorectal carcinoma Approved [62]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [63]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [64]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [65]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [66]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [65]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [67]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [68]
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Drug(s) Transported By Organic anion transporting polypeptide 1B1 (SLCO1B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [69]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [70]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [71]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [12]
Pravastatin DM6A0X7 Adult acute monocytic leukemia Approved [72]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [73]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [74]
Cerivastatin DMXCM7H Hyperlipidaemia 5C80 Approved [75]
PITAVASTATIN CALCIUM DM1UJO0 Dyslipidemia 5C80-5C81 Approved [72]
Rosuvastatin DMMIQ7G Arteriosclerosis BD40 Approved [76]
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Drug(s) Transported By Organic cation transporter 1 (SLC22A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [77]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [78]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [79]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [53]
Verapamil DMA7PEW Angina pectoris BA40 Approved [80]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [81]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [82]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [83]
Propranolol DM79NTF Angina pectoris BA40 Approved [84]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [53]
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Drug(s) Transported By Organic anion transporting polypeptide 1A2 (SLCO1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [85]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [86]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [87]
PITAVASTATIN CALCIUM DM1UJO0 Dyslipidemia 5C80-5C81 Approved [88]
Rosuvastatin DMMIQ7G Arteriosclerosis BD40 Approved [89]
Saquinavir DMG814N Human immunodeficiency virus infection 1C62 Approved [90]
Enalapril DMNFUZR Congestive heart failure BD10 Approved [91]
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [92]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [93]
Labetalol DMK8U72 Hypertension BA00-BA04 Approved [94]
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Drug(s) Transported By Organic anion transporting polypeptide 1B3 (SLCO1B3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [95]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [96]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [97]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [12]
Pravastatin DM6A0X7 Adult acute monocytic leukemia Approved [98]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [73]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [75]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [99]
Cerivastatin DMXCM7H Hyperlipidaemia 5C80 Approved [75]
PITAVASTATIN CALCIUM DM1UJO0 Dyslipidemia 5C80-5C81 Approved [100]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [101]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [102]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [103]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [104]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [105]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [106]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [107]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [102]
Verapamil DMA7PEW Angina pectoris BA40 Approved [15]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [108]
Eplerenone DMF0NQR Heart failure BD10-BD13 Approved [155]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [156]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [157]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [158]
Proguanil DMBL79I Malaria 1F40-1F45 Approved [159]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [159]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [160]
Nelfinavir mesylate DMFX6G8 N. A. N. A. Approved [161]
Capsaicin DMGMF6V Back pain ME84.Z Approved [162]
Axitinib DMGVH6N Renal cell carcinoma 2C90 Approved [163]
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Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [109]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [110]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [111]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [112]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [113]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [106]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [114]
Verapamil DMA7PEW Angina pectoris BA40 Approved [115]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [116]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [117]
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Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [118]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [119]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [120]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [105]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [121]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [122]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [123]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [124]
Propranolol DM79NTF Angina pectoris BA40 Approved [125]
Amitriptyline DMK7F9S Depression 6A70-6A7Z Approved [126]
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Drug(s) Metabolized By Cytochrome P450 3A5 (CYP3A5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [127]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [128]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [129]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [20]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [130]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [131]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [132]
Verapamil DMA7PEW Angina pectoris BA40 Approved [133]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [20]
Estrone DM5T6US Acne vulgaris ED80 Approved [134]
Eplerenone DMF0NQR Heart failure BD10-BD13 Approved [155]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [156]
Nelfinavir mesylate DMFX6G8 N. A. N. A. Approved [161]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [161]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [164]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [165]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [166]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [167]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [168]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [169]
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Drug(s) Metabolized By Cytochrome P450 3A7 (CYP3A7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [135]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [20]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [20]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [136]
Verapamil DMA7PEW Angina pectoris BA40 Approved [137]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [20]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [20]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [20]
Metronidazole DMTIVEN Abscess Approved [138]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [139]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [170]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [167]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [165]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [171]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [172]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [173]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [174]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [175]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [176]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [177]
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Drug(s) Metabolized By Cytochrome P450 2C8 (CYP2C8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [109]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [19]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [136]
Verapamil DMA7PEW Angina pectoris BA40 Approved [140]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [141]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [142]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [19]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [143]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [144]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [145]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [178]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [179]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [178]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [179]
Sulfinpyrazone DMEV954 Gout FA25 Approved [180]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [178]
Zafirlukast DMHNQOG Asthma CA23 Approved [178]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [178]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [181]
Dabrafenib DMX6OE3 Melanoma 2C30 Approved [182]
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Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [146]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [147]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [148]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [136]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [136]
Verapamil DMA7PEW Angina pectoris BA40 Approved [149]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [150]
Estrone DM5T6US Acne vulgaris ED80 Approved [151]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [152]
Pravastatin DM6A0X7 Adult acute monocytic leukemia Approved [153]
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Drug(s) Metabolized By Prostaglandin G/H synthase 1 (COX-1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [154]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [15]
Diazepam DM08E9O Alcohol withdrawal Approved [15]
Dapsone DM4LT8A Acne vulgaris ED80 Approved [15]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [15]
Nateglinide DMLK2QH Diabetic complication 5A2Y Approved [15]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [15]
Ketobemidone DMM3L6Z Pain MG30-MG3Z Approved [15]
Irbesartan DMTP1DC Diabetic kidney disease GB61.Z Approved [15]
Terbinafine DMI6HUW Fungal infection 1F29-1F2F Approved [15]
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Drug(s) Affected By Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [183]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [183]
Gefitinib DM15F0X Colon adenocarcinoma Approved [184]
Sunitinib DMCBJSR Acute undifferentiated leukemia Approved [185]
Rosuvastatin DMMIQ7G Arteriosclerosis BD40 Approved [186]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [187]
Methotrexate DM2TEOL Anterior urethra cancer Approved [188]
Quercetin DM3NC4M Obesity 5B81 Approved [189]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [190]
Folic Acid DMEMBJC Colorectal carcinoma Approved [191]
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Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [192]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [193]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [194]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [195]
Cepharanthine DM9Y5JB N. A. N. A. Approved [196]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [197]
Clozapine DMFC71L Schizophrenia 6A20 Approved [198]
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [199]
Trifluoperazine DMKBYWI Anxiety Approved [200]
Olanzapine DMPFN6Y Bipolar depression Approved [198]
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Drug(s) Affected By Aldehyde dehydrogenase, mitochondrial (ALDH2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [201]
Quercetin DM3NC4M Obesity 5B81 Approved [202]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [203]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [204]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [205]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [167]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [206]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [207]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [208]
Ethanol DMDRQZU Chronic pain MG30 Approved [209]
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Drug(s) Affected By Eukaryotic translation initiation factor 4E (EIF4E)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [210]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [211]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [212]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [213]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [214]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [208]
Momelotinib DMF98Q0 Myelofibrosis 2A20.2 Approved [215]
Flurbiprofen DMGN4BY Osteoarthritis FA00-FA05 Approved [214]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [216]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [217]
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Drug(s) Affected By Fructose-bisphosphate aldolase C (ALDOC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [218]
Quercetin DM3NC4M Obesity 5B81 Approved [202]
Fluoxetine DM3PD2C Bipolar depression Approved [219]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [176]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [220]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [221]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [167]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [168]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [208]
Ethanol DMDRQZU Chronic pain MG30 Approved [222]
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Drug(s) Affected By Pyruvate dehydrogenase E1 component subunit beta, mitochondrial (PDHB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [212]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [223]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [167]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [207]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [208]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [224]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [216]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [225]
DNCB DMDTVYC Immune System disease 4A01-4B41 Phase 2 [226]
THAPSIGARGIN DMDMQIE N. A. N. A. Preclinical [227]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase 4 (CDK4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [228]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [229]
Selenium DM25CGV N. A. N. A. Approved [230]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [231]
Methotrexate DM2TEOL Anterior urethra cancer Approved [232]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [233]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [234]
Quercetin DM3NC4M Obesity 5B81 Approved [235]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [236]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [203]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-A2 (CCNA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [237]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [238]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [239]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [240]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [241]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [242]
Methotrexate DM2TEOL Anterior urethra cancer Approved [243]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [244]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [245]
Quercetin DM3NC4M Obesity 5B81 Approved [202]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ribosomal protein S6 kinase beta-1 (RPS6KB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [246]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [247]
Gefitinib DM15F0X Colon adenocarcinoma Approved [248]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [249]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [250]
Quercetin DM3NC4M Obesity 5B81 Approved [251]
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [252]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [253]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [254]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [255]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Eukaryotic translation initiation factor 4B (EIF4B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [253]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [256]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [207]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [208]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [257]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [258]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [259]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [260]
Tamibarotene DM3G74J T-cell leukaemia 2A90 Phase 3 [253]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [261]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [262]
Quercetin DM3NC4M Obesity 5B81 Approved [263]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [176]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [264]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [265]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [266]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [267]
Testosterone DM7HUNW Hot flushes GA30 Approved [268]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [167]
Cantharidin DMBP5N3 Molluscum contagiosum infection 1E76 Approved [269]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By G1/S-specific cyclin-D3 (CCND3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [270]
Gefitinib DM15F0X Colon adenocarcinoma Approved [271]
Quercetin DM3NC4M Obesity 5B81 Approved [235]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [272]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [273]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [274]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [275]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [276]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [277]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [278]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [279]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [280]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [281]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [282]
Gefitinib DM15F0X Colon adenocarcinoma Approved [283]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [249]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [284]
Selenium DM25CGV N. A. N. A. Approved [285]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [286]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [287]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Hexokinase-4 (GCK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [288]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [289]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [290]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [289]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [168]
Folic Acid DMEMBJC Colorectal carcinoma Approved [291]
Arsenic DMTL2Y1 N. A. N. A. Approved [292]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [293]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [294]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [295]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/threonine-protein kinase mTOR (MTOR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [296]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [297]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [247]
Gefitinib DM15F0X Colon adenocarcinoma Approved [248]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [262]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [287]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [298]
Quercetin DM3NC4M Obesity 5B81 Approved [299]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [300]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [301]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PPP2CA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [302]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [303]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [304]
Pioglitazone DMKJ485 Amyotrophic lateral sclerosis 8B60.0 Approved [305]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [216]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [306]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [307]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [308]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [309]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [310]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [311]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [287]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [234]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [211]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [312]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [313]
Testosterone DM7HUNW Hot flushes GA30 Approved [314]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [167]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [315]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [208]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bile salt export pump (ABCB11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [316]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [317]
Glipizide DMZA5PQ Diabetic complication 5A2Y Approved [317]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [318]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [316]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [317]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [319]
Gefitinib DM15F0X Colon adenocarcinoma Approved [316]
Drospirenone DM1A9W3 Acne vulgaris ED80 Approved [320]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [316]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [321]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [322]
Gamolenic acid DMQN30Z Allergy 4A80-4A85 Approved [323]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [324]
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [325]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [326]
Ibandronate DM0QZBN Hypercalcaemia 5B91.0 Approved [327]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [328]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [329]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [330]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [331]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [332]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [333]
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [334]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [335]
Selenium DM25CGV N. A. N. A. Approved [336]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [331]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [337]
Methotrexate DM2TEOL Anterior urethra cancer Approved [338]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [337]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Autophagy-related protein 13 (ATG13)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [285]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [167]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [339]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [340]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [341]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [342]
GALLICACID DM6Y3A0 Discovery agent N.A. Investigative [343]
cycloheximide DMGDA3C Discovery agent N.A. Investigative [344]
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Drug(s) Affected By Platelet-derived growth factor subunit B (PDGFB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [345]
Ramipril DM2R68E Acute heart failure BD10-BD13 Approved [346]
Methotrexate DM2TEOL Anterior urethra cancer Approved [347]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [348]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [349]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [350]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [168]
Ethanol DMDRQZU Chronic pain MG30 Approved [349]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [351]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [352]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interferon gamma (IFNG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [353]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [354]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [355]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [356]
Methotrexate DM2TEOL Anterior urethra cancer Approved [347]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [357]
Quercetin DM3NC4M Obesity 5B81 Approved [358]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [359]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [360]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [361]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-1 beta (IL1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [333]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [362]
Gefitinib DM15F0X Colon adenocarcinoma Approved [363]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [329]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [364]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [329]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [365]
Selenium DM25CGV N. A. N. A. Approved [366]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [367]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [368]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Keratin, type I cytoskeletal 14 (KRT14)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [369]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [170]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [170]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [370]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [208]
Folic Acid DMEMBJC Colorectal carcinoma Approved [371]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [170]
Bexarotene DMOBIKY Cutaneous T-cell lymphoma 2B01 Approved [372]
Methamphetamine DMPM4SK Anxiety Approved [373]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [374]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cellular tumor antigen p53 (TP53)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [375]
Methotrexate DM2TEOL Anterior urethra cancer Approved [347]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [376]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [377]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [378]
Paclitaxel DMLB81S Breast carcinoma Approved [379]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [380]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [281]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [381]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [382]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Heat shock protein beta-1 (HSPB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [383]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [384]
Selenium DM25CGV N. A. N. A. Approved [285]
Methotrexate DM2TEOL Anterior urethra cancer Approved [385]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [386]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [387]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [388]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [278]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [389]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [208]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [390]
Riluzole DMECBWN Amyotrophic lateral sclerosis 8B60.0 Approved [391]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [392]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [393]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [394]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [395]
Ethacrynic acid DM60QMR Edema MG29 Approved [396]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [397]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [398]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [399]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Intercellular adhesion molecule 1 (ICAM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [400]
Dicloxacillin DM8EU0Z Bacterial infection 1A00-1C4Z Approved [400]
Ergonovine DM0VEC1 Postpartum haemorrhage JA43 Approved [185]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [401]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [402]
Mizolastine DM1FDN8 Allergic rhinitis CA08.0 Approved [403]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [404]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [405]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [406]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [407]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tyrosine-protein kinase Lck (LCK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [342]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [253]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [408]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [212]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [409]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [168]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [410]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [411]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [412]
Methotrexate DM2TEOL Anterior urethra cancer Approved [225]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase 1 (CDK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [270]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [238]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [413]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [258]
Selenium DM25CGV N. A. N. A. Approved [230]
Etretinate DM2CZFA Keratosis ED56 Approved [414]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [415]
Methotrexate DM2TEOL Anterior urethra cancer Approved [232]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [244]
Quercetin DM3NC4M Obesity 5B81 Approved [235]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cathepsin B (CTSB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [383]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [416]
Selenium DM25CGV N. A. N. A. Approved [285]
Quercetin DM3NC4M Obesity 5B81 Approved [202]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [417]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [386]
Pyrimethamine DM5X7VY Malaria 1F40-1F45 Approved [418]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [419]
Propylthiouracil DM6D7N8 Hyperthyroidism 5A02 Approved [420]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [421]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Proto-oncogene tyrosine-protein kinase receptor Ret (RET)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [422]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [423]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [422]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [203]
Irbesartan DMTP1DC Diabetic kidney disease GB61.Z Approved [424]
Estrone DM5T6US Acne vulgaris ED80 Approved [423]
Methazolamide DM7J2TA Glaucoma/ocular hypertension 9C61 Approved [422]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [425]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [168]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [426]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ATP-dependent 6-phosphofructokinase, muscle type (PFKM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [168]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [208]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [427]
Clotrimazole DMMFCIH Cutaneous candidiasis 1F23.14 Approved [24]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [309]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [260]
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [428]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [429]
Bardoxolone methyl DMODA2X Mixed connective tissue disease 4A43.3 Phase 3 [430]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [431]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Platelet-derived growth factor receptor beta (PDGFRB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [258]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [220]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [212]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [300]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [350]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [168]
Folic Acid DMEMBJC Colorectal carcinoma Approved [291]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [432]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [433]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [434]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [435]
Gefitinib DM15F0X Colon adenocarcinoma Approved [436]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [437]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [438]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [439]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [440]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [439]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [441]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [442]
Methotrexate DM2TEOL Anterior urethra cancer Approved [443]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [444]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [445]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [446]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [447]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [448]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [362]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [329]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [364]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [449]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [329]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [450]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [451]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [452]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [453]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [185]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [435]
Verapamil DMA7PEW Angina pectoris BA40 Approved [454]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [455]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [456]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [282]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [457]
2-deoxyglucose DMIAHVU Solid tumour/cancer 2A00-2F9Z Approved [458]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [459]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [218]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [460]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [461]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [460]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [220]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [190]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [276]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Breakpoint cluster region protein (BCR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [235]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [203]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [276]
Nilotinib DM7HXWT Chronic myelogenous leukaemia 2A20.0 Approved [462]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [207]
Folic Acid DMEMBJC Colorectal carcinoma Approved [291]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [463]
Bortezomib DMNO38U Leukemia Approved [464]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [216]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [465]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Lysosome-associated membrane glycoprotein 1 (LAMP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [218]
Selenium DM25CGV N. A. N. A. Approved [285]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [220]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [466]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [168]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [208]
Ethanol DMDRQZU Chronic pain MG30 Approved [467]
Clozapine DMFC71L Schizophrenia 6A20 Approved [218]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [468]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [224]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ornithine decarboxylase (ODC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [435]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [469]
Methotrexate DM2TEOL Anterior urethra cancer Approved [470]
Quercetin DM3NC4M Obesity 5B81 Approved [471]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [170]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [170]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [277]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [223]
Propranolol DM79NTF Angina pectoris BA40 Approved [472]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [473]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Keratin, type II cytoskeletal 5 (KRT5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [369]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [170]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [170]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [474]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [475]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [168]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [208]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [170]
Bexarotene DMOBIKY Cutaneous T-cell lymphoma 2B01 Approved [372]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [476]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tissue factor (F3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [477]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [478]
Methotrexate DM2TEOL Anterior urethra cancer Approved [479]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [480]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [481]
Quercetin DM3NC4M Obesity 5B81 Approved [482]
Fructose DM43AN2 Vomiting MD90 Approved [483]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [484]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [478]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [204]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Histone H2AX (H2AX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [485]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [486]
Selenium DM25CGV N. A. N. A. Approved [285]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [487]
Etretinate DM2CZFA Keratosis ED56 Approved [488]
Methotrexate DM2TEOL Anterior urethra cancer Approved [489]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [490]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [491]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [492]
Quercetin DM3NC4M Obesity 5B81 Approved [493]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Platelet-derived growth factor receptor alpha (PDGFRA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [342]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [386]
Panobinostat DM58WKG Chronic graft versus host disease Approved [494]
Vismodegib DM5IXKQ Basal cell carcinoma 2C32 Approved [495]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [290]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [207]
Folic Acid DMEMBJC Colorectal carcinoma Approved [496]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [497]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [498]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [434]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CCAAT/enhancer-binding protein beta (CEBPB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [435]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [258]
Methotrexate DM2TEOL Anterior urethra cancer Approved [338]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [499]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [500]
Quercetin DM3NC4M Obesity 5B81 Approved [501]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [236]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [253]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [502]
Panobinostat DM58WKG Chronic graft versus host disease Approved [494]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Histidine decarboxylase (HDC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [503]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [504]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [505]
Nilotinib DM7HXWT Chronic myelogenous leukaemia 2A20.0 Approved [506]
Isoflurophate DMBSK7X Glaucoma/ocular hypertension 9C61 Approved [507]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [168]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [494]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [507]
phorbol 12-myristate 13-acetate DMJWD62 Acute myeloid leukaemia 2A60 Phase 2 [508]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [295]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor EB (TFEB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [285]
Fluphenazine DMIT8LX Psychotic disorder 6A20-6A25 Approved [509]
Prochlorperazine DM53SRA Nausea MD90 Approved [509]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [466]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [290]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [207]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [510]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [217]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [389]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [511]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fibroblast growth factor receptor 3 (FGFR3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [202]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [264]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [212]
Panobinostat DM58WKG Chronic graft versus host disease Approved [494]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [313]
Lenalidomide DM6Q7U4 Adult T-cell leukemia/lymphoma Approved [512]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [512]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [278]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [167]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [168]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Insulin-like growth factor-binding protein 4 (IGFBP4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [239]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [513]
Selenium DM25CGV N. A. N. A. Approved [285]
Methotrexate DM2TEOL Anterior urethra cancer Approved [338]
Quercetin DM3NC4M Obesity 5B81 Approved [202]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [505]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [212]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [514]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [278]
Leflunomide DMR8ONJ Arthritis FA20 Approved [515]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Alanine aminotransferase 1 (GPT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Halothane DM80OZ5 Anaesthesia 9A78.6 Approved [185]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [516]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [517]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [185]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [185]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [185]
Gefitinib DM15F0X Colon adenocarcinoma Approved [21]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [518]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [21]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [21]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-4 receptor subunit alpha (IL4R)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [258]
Selenium DM25CGV N. A. N. A. Approved [285]
Methotrexate DM2TEOL Anterior urethra cancer Approved [232]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [357]
Quercetin DM3NC4M Obesity 5B81 Approved [519]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [203]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [520]
Testosterone DM7HUNW Hot flushes GA30 Approved [521]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [425]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [350]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase 2 (CDK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [270]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [238]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [522]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [523]
Selenium DM25CGV N. A. N. A. Approved [230]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [440]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [524]
Methotrexate DM2TEOL Anterior urethra cancer Approved [525]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [233]
Quercetin DM3NC4M Obesity 5B81 Approved [235]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NF-kappa-B inhibitor alpha (NFKBIA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fructose DM43AN2 Vomiting MD90 Approved [185]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [526]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [333]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [362]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [302]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [527]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [528]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [529]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [530]
Quercetin DM3NC4M Obesity 5B81 Approved [202]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [531]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [532]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [533]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [456]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [534]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [535]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [536]
Gefitinib DM15F0X Colon adenocarcinoma Approved [537]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [538]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [539]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [540]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [532]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [541]
Paclitaxel DMLB81S Breast carcinoma Approved [542]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [543]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [531]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [185]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [333]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [456]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [534]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-1 (CASP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [333]
Gefitinib DM15F0X Colon adenocarcinoma Approved [363]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [544]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [365]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [406]
Quercetin DM3NC4M Obesity 5B81 Approved [519]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [505]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [204]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [545]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [546]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Catenin beta-1 (CTNNB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [547]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [548]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [549]
Quercetin DM3NC4M Obesity 5B81 Approved [457]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [550]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [551]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [552]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [553]
Testosterone DM7HUNW Hot flushes GA30 Approved [554]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [555]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [556]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [557]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [558]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [378]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [559]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [560]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [561]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [562]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [563]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [526]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Crk-like protein (CRKL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nilotinib DM7HXWT Chronic myelogenous leukaemia 2A20.0 Approved [564]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [208]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [565]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [566]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [567]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [260]
Rigosertib DMOSTXF Myelodysplastic syndrome 2A37 Phase 3 [568]
DNCB DMDTVYC Immune System disease 4A01-4B41 Phase 2 [226]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [569]
PMID25656651-Compound-5 DMAI95U Chronic myeloid leukaemia 2A20 Patented [570]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glycogen synthase kinase-3 beta (GSK3B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [571]
Gefitinib DM15F0X Colon adenocarcinoma Approved [572]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [573]
Selenium DM25CGV N. A. N. A. Approved [285]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [574]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [575]
Quercetin DM3NC4M Obesity 5B81 Approved [576]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [577]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [203]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [578]
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Drug(s) Affected By Hexokinase-2 (HK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [258]
Epinephrine DM3KJBC Acute asthma CA23 Approved [579]
Quercetin DM3NC4M Obesity 5B81 Approved [202]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [220]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [580]
Leflunomide DMR8ONJ Arthritis FA20 Approved [515]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [350]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [168]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [581]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [582]
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Drug(s) Affected By Small ribosomal subunit protein eS6 (RPS6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [583]
Methotrexate DM2TEOL Anterior urethra cancer Approved [338]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [584]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [254]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [370]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [585]
Testosterone DM7HUNW Hot flushes GA30 Approved [314]
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [279]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [167]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [586]
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Drug(s) Affected By Heat shock factor protein 1 (HSF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [587]
SPI-1005 DM6XFHS Reperfusion injury ND56.Z Approved [588]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [588]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [589]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [590]
Ceftazidime DM41GRA Bacteremia 1A73 Approved [588]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [203]
Chlorpheniramine DM5URA2 Allergic rhinitis CA08.0 Approved [588]
Ethacrynic acid DM60QMR Edema MG29 Approved [588]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [588]
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Drug(s) Affected By Transcription factor p65 (RELA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [333]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [282]
Selenium DM25CGV N. A. N. A. Approved [285]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [415]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [591]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [530]
Quercetin DM3NC4M Obesity 5B81 Approved [202]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [592]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [253]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [593]
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Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [450]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [526]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [435]
Verapamil DMA7PEW Angina pectoris BA40 Approved [454]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [416]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [594]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [595]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [548]
Meloxicam DM2AR7L Arthritis FA20 Approved [596]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [440]
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Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [281]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [597]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [438]
Selenium DM25CGV N. A. N. A. Approved [285]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [598]
Methotrexate DM2TEOL Anterior urethra cancer Approved [232]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [599]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [600]
Quercetin DM3NC4M Obesity 5B81 Approved [576]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [395]
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Drug(s) Affected By Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [456]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [416]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [601]
Methotrexate DM2TEOL Anterior urethra cancer Approved [525]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [602]
Quercetin DM3NC4M Obesity 5B81 Approved [457]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [603]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [416]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [604]
Ethacrynic acid DM60QMR Edema MG29 Approved [605]
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Drug(s) Affected By Forkhead box protein M1 (FOXM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [413]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [240]
Methotrexate DM2TEOL Anterior urethra cancer Approved [243]
Quercetin DM3NC4M Obesity 5B81 Approved [202]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [236]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [203]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [606]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [607]
Testosterone DM7HUNW Hot flushes GA30 Approved [521]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [521]
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Drug(s) Affected By Potassium voltage-gated channel subfamily H member 2 (KCNH2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Metoclopramide DMFA5MY Nausea MD90 Approved [608]
Quinidine DMLPICK N. A. N. A. Approved [609]
Verapamil DMA7PEW Angina pectoris BA40 Approved [610]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [611]
Clarithromycin DM4M1SG Acute maxillary sinusitis Approved [611]
Disopyramide DM5SYZP Long QT syndrome BC65.0 Approved [612]
Propranolol DM79NTF Angina pectoris BA40 Approved [613]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [614]
Dofetilide DMPN1TW Sinus rhythm disorder BC9Y Approved [615]
Flecainide DMSQDLE Tachyarrhythmias BC71 Approved [611]
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Drug(s) Affected By Sequestosome-1 (SQSTM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [297]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [247]
Gefitinib DM15F0X Colon adenocarcinoma Approved [616]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [384]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [617]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [618]
Methotrexate DM2TEOL Anterior urethra cancer Approved [232]
Quercetin DM3NC4M Obesity 5B81 Approved [202]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [236]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [505]
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Drug(s) Affected By Beclin-1 (BECN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcipotriol DM03CP7 Psoriasis EA90 Approved [619]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [435]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [262]
Methotrexate DM2TEOL Anterior urethra cancer Approved [232]
Quercetin DM3NC4M Obesity 5B81 Approved [620]
Fluoxetine DM3PD2C Bipolar depression Approved [621]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [622]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [623]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [624]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [625]
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Drug(s) Affected By Nuclear receptor subfamily 0 group B member 2 (NR0B2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcipotriol DM03CP7 Psoriasis EA90 Approved [626]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [627]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [328]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [628]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [629]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [627]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [630]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [631]
Quercetin DM3NC4M Obesity 5B81 Approved [202]
Fluoxetine DM3PD2C Bipolar depression Approved [627]
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Drug(s) Affected By NGFI-A-binding protein 2 (NAB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [328]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [258]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [632]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [278]
Leflunomide DMR8ONJ Arthritis FA20 Approved [515]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [350]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [434]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [633]
Bortezomib DMNO38U Leukemia Approved [464]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [216]
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Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [383]
Verapamil DMA7PEW Angina pectoris BA40 Approved [634]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [635]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [364]
Selenium DM25CGV N. A. N. A. Approved [285]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [636]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [637]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [638]
Quercetin DM3NC4M Obesity 5B81 Approved [202]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [639]
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Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [391]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [240]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [640]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [641]
Estrone DM5T6US Acne vulgaris ED80 Approved [642]
Melatonin DMKWFBT Depression 6A70-6A7Z Approved [643]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [644]
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [645]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [646]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [447]
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Drug(s) Affected By TRAF family member-associated NF-kappa-B activator (TANK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [548]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [203]
Testosterone DM7HUNW Hot flushes GA30 Approved [268]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [168]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [647]
Menthol DMG2KW7 Back pain ME84.Z Approved [648]
Bortezomib DMNO38U Leukemia Approved [464]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [649]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [650]
Arsenic DMTL2Y1 N. A. N. A. Approved [651]
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Drug(s) Affected By NACHT, LRR and PYD domains-containing protein 3 (NLRP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [333]
Selenium DM25CGV N. A. N. A. Approved [366]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [203]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [652]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [546]
Testosterone DM7HUNW Hot flushes GA30 Approved [268]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [653]
Ethanol DMDRQZU Chronic pain MG30 Approved [654]
Atropine DMEN6X7 Organophosphate poisoning NE6Z Approved [655]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [655]
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Drug(s) Affected By Bile acid receptor (NR1H4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [628]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [656]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [657]
Quercetin DM3NC4M Obesity 5B81 Approved [202]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [658]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [265]
Nisoldipine DM7ISKJ Hypertension BA00-BA04 Approved [656]
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [657]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [167]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [659]
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Drug(s) Affected By Docking protein 1 (DOK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [268]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [168]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [660]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [339]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [566]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [260]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [285]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [661]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [662]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [341]
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Drug(s) Affected By Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [247]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [262]
Methotrexate DM2TEOL Anterior urethra cancer Approved [232]
Quercetin DM3NC4M Obesity 5B81 Approved [202]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [663]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [265]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [664]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [466]
Trovafloxacin DM6AN32 Acute gonococcal cervicitis Approved [665]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [301]
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Drug(s) Affected By Transcription factor SOX-17 (SOX17)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gefitinib DM15F0X Colon adenocarcinoma Approved [666]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [666]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [666]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [666]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [666]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [667]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [497]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [666]
Ziprasidone DMM58JY Bipolar disorder 6A60 Approved [666]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [668]
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Drug(s) Affected By V-type proton ATPase subunit H (ATP6V1H)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Leflunomide DMR8ONJ Arthritis FA20 Approved [515]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [168]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [208]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [216]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [669]
Urethane DM7NSI0 N. A. N. A. Phase 4 [670]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [569]
PP-242 DM2348V Discovery agent N.A. Investigative [671]
Milchsaure DM462BT Pruritus EC90 Investigative [672]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [647]
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Drug(s) Affected By Tyrosine-protein kinase ABL1 (ABL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydroxyurea DMOQVU9 Chronic myelogenous leukaemia 2A20.0 Approved [185]
Anagrelide DMSQ8MD Thrombocythemia 3B63 Approved [185]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [673]
Quercetin DM3NC4M Obesity 5B81 Approved [674]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [276]
Testosterone DM7HUNW Hot flushes GA30 Approved [521]
Nilotinib DM7HXWT Chronic myelogenous leukaemia 2A20.0 Approved [564]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [521]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [675]
Capsaicin DMGMF6V Back pain ME84.Z Approved [676]
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Drug(s) Affected By LYR motif-containing protein 9 (LYRM9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Liothyronine DM6IR3P Congenital hypothyroidism Approved [677]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [207]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [432]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [339]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [293]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [260]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [678]
GSK2110183 DMZHB37 leukaemia 2A60-2B33 Phase 2 [679]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [680]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [295]
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Drug(s) Affected By Leptin (LEP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [681]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [682]
Ramipril DM2R68E Acute heart failure BD10-BD13 Approved [683]
Quercetin DM3NC4M Obesity 5B81 Approved [684]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [685]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [681]
Stavudine DM6DEK9 Human immunodeficiency virus infection 1C62 Approved [681]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [686]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [687]
Amlodipine DMBDAZV Angina pectoris BA40 Approved [688]
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Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [413]
Gefitinib DM15F0X Colon adenocarcinoma Approved [689]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [690]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [438]
Etretinate DM2CZFA Keratosis ED56 Approved [414]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [618]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [691]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [692]
Quercetin DM3NC4M Obesity 5B81 Approved [693]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [694]
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Drug(s) Affected By Bcl-2-like protein 11 (BCL2L11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [695]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [250]
Quercetin DM3NC4M Obesity 5B81 Approved [696]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [203]
Remdesivir DMBFZ6L Coronavirus Disease 2019 (COVID-19) 1D6Y Approved [697]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [698]
Panobinostat DM58WKG Chronic graft versus host disease Approved [494]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [699]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [700]
Testosterone DM7HUNW Hot flushes GA30 Approved [268]
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Drug(s) Affected By Tyrosine-protein kinase Lyn (LYN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [342]
Quercetin DM3NC4M Obesity 5B81 Approved [202]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [386]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [212]
Panobinostat DM58WKG Chronic graft versus host disease Approved [494]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [409]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [701]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [207]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [208]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [497]
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Drug(s) Affected By Serine/threonine-protein kinase PLK1 (PLK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [270]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [240]
Methotrexate DM2TEOL Anterior urethra cancer Approved [243]
Quercetin DM3NC4M Obesity 5B81 Approved [202]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [236]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [702]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [703]
Testosterone DM7HUNW Hot flushes GA30 Approved [521]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [521]
Leflunomide DMR8ONJ Arthritis FA20 Approved [515]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Fusion protein Bcr-Abl (Bcr-Abl) TTS7G69 BCR_HUMAN-ABL1_HUMAN Inhibitor [8]
Mcl-1 messenger RNA (MCL-1 mRNA) TTN6ORK MCL1_HUMAN Not Available [7]
Platelet-derived growth factor receptor (PDGFR) TTI2WET NOUNIPROTAC Inhibitor [8]
Tyrosine-protein kinase Kit (KIT) TTX41N9 KIT_HUMAN Inhibitor [8]
HUMAN fusion protein Bcr-Abl (Bcr-Abl) TTE63HY BCR_HUMAN/ABL1_HUMAN Inhibitor [6]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Organic cation transporter 1 (SLC22A1) DTT79CX S22A1_HUMAN Substrate [9]
Organic anion transporting polypeptide 1A2 (SLCO1A2) DTE2B1D SO1A2_HUMAN Substrate [10]
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [11]
Organic anion transporting polypeptide 1B1 (SLCO1B1) DT3D8F0 SO1B1_HUMAN Substrate [12]
Organic anion transporting polypeptide 1B3 (SLCO1B3) DT9C1TS SO1B3_HUMAN Substrate [12]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [13]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [14]
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Substrate [15]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Substrate [16]
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Substrate [17]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Substrate [18]
Cytochrome P450 2C8 (CYP2C8) DES5XRU CP2C8_HUMAN Substrate [19]
Cytochrome P450 3A7 (CYP3A7) DERD86B CP3A7_HUMAN Substrate [20]
Prostaglandin G/H synthase 1 (COX-1) DE073H6 PGH1_HUMAN Substrate [15]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Alanine aminotransferase 1 (GPT) OTOXOA0Q ALAT1_HUMAN Protein Interaction/Cellular Processes [21]
Aldehyde dehydrogenase, mitochondrial (ALDH2) OTKJ9I3N ALDH2_HUMAN Gene/Protein Processing [22]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [23]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [23]
ATP-dependent 6-phosphofructokinase, muscle type (PFKM) OT1QY9JM PFKAM_HUMAN Gene/Protein Processing [24]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Gene/Protein Processing [25]
Autophagy-related protein 13 (ATG13) OTYMHNEJ ATG13_HUMAN Post-Translational Modifications [26]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Drug Response [27]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Gene/Protein Processing [28]
Bcl-2-like protein 11 (BCL2L11) OTNQQWFJ B2L11_HUMAN Drug Response [29]

References

1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2 Imatinib FDA Label
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5687).
4 FDA Approved Drug Products from FDA Official Website. 2019. Application Number: (ANDA) 078340.
5 ClinicalTrials.gov (NCT04356495) Treatments to Decrease the Risk of Hospitalization or Death in Elderly Outpatients With Symptomatic SARS-CoV-2 Infection (COVID-19). U.S. National Institutes of Health.
6 Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47.
7 Design and development of antisense drugs. Expert Opin. Drug Discov. 2008 3(10):1189-1207.
8 A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22.
9 Pharmacologic markers and predictors of responses to imatinib therapy in patients with chronic myeloid leukemia. Leuk Lymphoma. 2008 Apr;49(4):639-42.
10 Environmental and genetic factors affecting transport of imatinib by OATP1A2. Clin Pharmacol Ther. 2011 Jun;89(6):816-20.
11 Imatinib mesylate (STI571) is a substrate for the breast cancer resistance protein (BCRP)/ABCG2 drug pump. Blood. 2004 Nov 1;104(9):2940-2.
12 Contribution of OATP1B1 and OATP1B3 to the disposition of sorafenib and sorafenib-glucuronide. Clin Cancer Res. 2013 Mar 15;19(6):1458-66.
13 Association of genetic polymorphisms in the influx transporter SLCO1B3 and the efflux transporter ABCB1 with imatinib pharmacokinetics in patients with chronic myeloid leukemia. Ther Drug Monit. 2011 Apr;33(2):244-50.
14 Potent mechanism-based inhibition of CYP3A4 by imatinib explains its liability to interact with CYP3A4 substrates. Br J Pharmacol. 2012 Apr;165(8):2787-98.
15 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
16 Drug-drug interactions with imatinib: an observational study. Medicine (Baltimore). 2016 Oct;95(40):e5076.
17 The effect of apigenin on pharmacokinetics of imatinib and its metabolite N-desmethyl imatinib in rats. Biomed Res Int. 2013;2013:789184.
18 Clinical pharmacokinetics of imatinib. Clin Pharmacokinet. 2005;44(9):879-94.
19 Role of cytochrome P450 2C8 in drug metabolism and interactions. Pharmacol Rev. 2016 Jan;68(1):168-241.
20 Drug Interactions Flockhart Table
21 Cytotoxicity of 34 FDA approved small-molecule kinase inhibitors in primary rat and human hepatocytes. Toxicol Lett. 2018 Jul;291:138-148. doi: 10.1016/j.toxlet.2018.04.010. Epub 2018 Apr 12.
22 A systems biology understanding of the synergistic effects of arsenic sulfide and Imatinib in BCR/ABL-associated leukemia. Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3378-83.
23 Saikosaponin D disrupts platelet-derived growth factor- receptor/p38 pathway leading to mitochondrial apoptosis in human LO2 hepatocyte cells: a potential mechanism of hepatotoxicity. Chem Biol Interact. 2013 Oct 25;206(1):76-82. doi: 10.1016/j.cbi.2013.08.006. Epub 2013 Aug 28.
24 Combination of imatinib and clotrimazole enhances cell growth inhibition in T47D breast cancer cells. Chem Biol Interact. 2015 May 25;233:147-56. doi: 10.1016/j.cbi.2015.03.028. Epub 2015 Apr 8.
25 Chronic imatinib mesylate exposure leads to reduced intracellular drug accumulation by induction of the ABCG2 (BCRP) and ABCB1 (MDR1) drug transport pumps. Cancer Biol Ther. 2005 Jul;4(7):747-52.
26 Imatinib disturbs lysosomal function and morphology and impairs the activity of mTORC1 in human hepatocyte cell lines. Food Chem Toxicol. 2022 Apr;162:112869. doi: 10.1016/j.fct.2022.112869. Epub 2022 Feb 16.
27 Disruption of the inhibitor of apoptosis protein survivin sensitizes Bcr-abl-positive cells to STI571-induced apoptosis. Cancer Res. 2005 Sep 15;65(18):8224-32. doi: 10.1158/0008-5472.CAN-05-0303.
28 The catalytic DNA topoisomerase II inhibitor dexrazoxane (ICRF-187) induces differentiation and apoptosis in human leukemia K562 cells. Mol Pharmacol. 2001 Mar;59(3):453-61. doi: 10.1124/mol.59.3.453.
29 Epigenetic down-regulation of BIM expression is associated with reduced optimal responses to imatinib treatment in chronic myeloid leukaemia. Eur J Cancer. 2009 Jul;45(10):1877-89. doi: 10.1016/j.ejca.2009.04.005. Epub 2009 May 4.
30 2007 FDA drug approvals: a year of flux. Nat Rev Drug Discov. 2008 Feb;7(2):107-9.
31 Asciminib in Chronic Myeloid Leukemia after ABL Kinase Inhibitor Failure. N Engl J Med. 2019 Dec 12;381(24):2315-2326.
32 Danusertib, an aurora kinase inhibitor.Expert Opin Investig Drugs.2012 Mar;21(3):383-93.
33 ABL001, a Potent Allosteric Inhibitor of BCR-ABL, Prevents Emergence of Resistant Disease When Administered in Combination with Nilotinib in an in Vivo Murine Model of Chronic Myeloid Leukemia, NorthBuilding, 2014, 120-125.
34 Ponatinib efficacy and safety in Philadelphia chromosome-positive leukemia: final 5-year results of the phase 2 PACE trial. Blood. 2018 Jul 26;132(4):393-404.
35 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
36 Design, synthesis and preclinical evaluation of NRC-AN-019. Int J Oncol. 2013 Jan;42(1):168-78.
37 Preclinical development of HQP1351, a multikinase inhibitor targeting a broad spectrum of mutant KIT kinases, for the treatment of imatinib-resistant gastrointestinal stromal tumors. Cell Biosci. 2019 Oct 26;9:88.
38 NPB001-05 inhibits Bcr-Abl kinase leading to apoptosis of imatinib-resistant cells. Front Biosci (Elite Ed). 2011 Jun 1;3:1273-88.
39 Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92.
40 2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81.
41 Emerging drugs for diabetic foot ulcers. Expert Opin Emerg Drugs. 2006 Nov;11(4):709-24.
42 Osteitis fibrosa is mediated by Platelet-Derived Growth Factor-A via a phosphoinositide 3-kinase-dependent signaling pathway in a rat model for chr... Endocrinology. 2008 Nov;149(11):5735-46.
43 National Cancer Institute Drug Dictionary (drug id 695817).
44 Vorolanib, an oral VEGFR/PDGFR dual tyrosine kinase inhibitor for treatment of patients with advanced solid tumors: An open-label, phase I dose escalation and dose expansion trial. Chin J Cancer Res. 2021 Feb 28;33(1):103-114.
45 Evaluation of WO-2014132220, selective PDGFR inhibitors for the treatment of pulmonary arterial hypertension.Expert Opin Ther Pat. 2015 Apr;25(4):493-9.
46 Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling.Mol Cancer Ther.2008 Oct;7(10):3129-40.
47 New anilinophthalazines as potent and orally well absorbed inhibitors of the VEGF receptor tyrosine kinases useful as antagonists of tumor-driven a... J Med Chem. 2000 Jun 15;43(12):2310-23.
48 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019
49 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020
50 Metabolism and bioactivation of famitinib, a novel inhibitor of receptor tyrosine kinase, in cancer patients. Br J Pharmacol. 2013 Apr;168(7):1687-706.
51 National Cancer Institute Drug Dictionary (drug id 452042).
52 Phase 1B study of amuvatinib in combination with five standard cancer therapies in adults with advanced solid tumors. Cancer Chemother Pharmacol. 2014 Jul;74(1):195-204.
53 Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007.
54 MDR1 (ABCB1) G1199A (Ser400Asn) polymorphism alters transepithelial permeability and sensitivity to anticancer agents. Cancer Chemother Pharmacol. 2009 Jun;64(1):183-8.
55 Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64.
56 Folate transporter expression decreases in the human placenta throughout pregnancy and in pre-eclampsia. Pregnancy Hypertens. 2012 Apr;2(2):123-31.
57 Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein. Pharm Res. 2001 Dec;18(12):1660-8.
58 Antiestrogens and steroid hormones: substrates of the human P-glycoprotein. Biochem Pharmacol. 1994 Jul 19;48(2):287-92.
59 Efflux ratio cannot assess P-glycoprotein-mediated attenuation of absorptive transport: asymmetric effect of P-glycoprotein on absorptive and secretory transport across Caco-2 cell monolayers. Pharm Res. 2003 Aug;20(8):1200-9.
60 Doxorubicin transport by RALBP1 and ABCG2 in lung and breast cancer. Int J Oncol. 2007 Mar;30(3):717-25.
61 Wild-type breast cancer resistance protein (BCRP/ABCG2) is a methotrexate polyglutamate transporter. Cancer Res. 2003 Sep 1;63(17):5538-43.
62 The effect of low pH on breast cancer resistance protein (ABCG2)-mediated transport of methotrexate, 7-hydroxymethotrexate, methotrexate diglutamate, folic acid, mitoxantrone, topotecan, and resveratrol in in vitro drug transport models. Mol Pharmacol. 2007 Jan;71(1):240-9.
63 Role of BCRP as a biomarker for predicting resistance to 5-fluorouracil in breast cancer. Cancer Chemother Pharmacol. 2009 May;63(6):1103-10.
64 Inhibiting the function of ABCB1 and ABCG2 by the EGFR tyrosine kinase inhibitor AG1478. Biochem Pharmacol. 2009 Mar 1;77(5):781-93.
65 Sterol transport by the human breast cancer resistance protein (ABCG2) expressed in Lactococcus lactis. J Biol Chem. 2003 Jun 6;278(23):20645-51.
66 The phytoestrogen genistein enhances multidrug resistance in breast cancer cell lines by translational regulation of ABC transporters. Cancer Lett. 2016 Jun 28;376(1):165-72.
67 Curcumin inhibits the activity of ABCG2/BCRP1, a multidrug resistance-linked ABC drug transporter in mice. Pharm Res. 2009 Feb;26(2):480-7.
68 Characterization of 3-methoxy flavones for their interaction with ABCG2 as suggested by ATPase activity. Biochim Biophys Acta. 2014 Nov;1838(11):2929-38.
69 Preclinical Mouse Models To Study Human OATP1B1- and OATP1B3-Mediated Drug-Drug Interactions in Vivo. Mol Pharm. 2015 Dec 7;12(12):4259-69.
70 Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev. 2011 Mar;63(1):157-81.
71 Identification of drugs and drug metabolites as substrates of multidrug resistance protein 2 (MRP2) using triple-transfected MDCK-OATP1B1-UGT1A1-MRP2 cells. Br J Pharmacol. 2012 Mar;165(6):1836-1847.
72 The effect of SLCO1B1*15 on the disposition of pravastatin and pitavastatin is substrate dependent: the contribution of transporting activity changes by SLCO1B1*15. Pharmacogenet Genomics. 2008 May;18(5):424-33.
73 Influence of SLCO1B1, 1B3, 2B1 and ABCC2 genetic polymorphisms on mycophenolic acid pharmacokinetics in Japanese renal transplant recipients. Eur J Clin Pharmacol. 2007 Dec;63(12):1161-9.
74 Rifampicin alters atorvastatin plasma concentration on the basis of SLCO1B1 521T>C polymorphism. Clin Chim Acta. 2009 Jul;405(1-2):49-52.
75 FDA Drug Development and Drug Interactions
76 Involvement of multiple transporters in the hepatobiliary transport of rosuvastatin. Drug Metab Dispos. 2008 Oct;36(10):2014-23.
77 Are organic cation transporters capable of transporting prostaglandins? Naunyn Schmiedebergs Arch Pharmacol. 2005 Aug;372(2):125-30.
78 Cisplatin and oxaliplatin, but not carboplatin and nedaplatin, are substrates for human organic cation transporters (SLC22A1-3 and multidrug and toxin extrusion family). J Pharmacol Exp Ther. 2006 Nov;319(2):879-86.
79 Organic cation transporters are determinants of oxaliplatin cytotoxicity. Cancer Res. 2006 Sep 1;66(17):8847-57.
80 Implications of genetic polymorphisms in drug transporters for pharmacotherapy. Cancer Lett. 2006 Mar 8;234(1):4-33.
81 Upregulation of histone acetylation reverses organic anion transporter 2 repression and enhances 5-fluorouracil sensitivity in hepatocellular carcinoma
82 Comparison of type I and type II organic cation transport by organic cation transporters and organic anion-transporting polypeptides. J Pharmacol Exp Ther. 2001 Jul;298(1):110-5.
83 Organic cation transporters and their pharmacokinetic and pharmacodynamic consequences. Drug Metab Pharmacokinet. 2008;23(4):243-53.
84 Influx Transport of Cationic Drug at the Blood-Retinal Barrier: Impact on the Retinal Delivery of Neuroprotectants. Biol Pharm Bull. 2017;40(8):1139-1145.
85 Interaction of methotrexate with organic-anion transporting polypeptide 1A2 and its genetic variants. J Pharmacol Exp Ther. 2006 Aug;318(2):521-9.
86 Localization of organic anion transporting polypeptide 4 (Oatp4) in rat liver and comparison of its substrate specificity with Oatp1, Oatp2 and Oatp3. Pflugers Arch. 2001 Nov;443(2):188-95.
87 Influence of the flavonoids apigenin, kaempferol, and quercetin on the function of organic anion transporting polypeptides 1A2 and 2B1. Biochem Pharmacol. 2010 Dec 1;80(11):1746-53.
88 Transporter-mediated influx and efflux mechanisms of pitavastatin, a new inhibitor of HMG-CoA reductase. J Pharm Pharmacol. 2005 Oct;57(10):1305-11.
89 Drug and bile acid transporters in rosuvastatin hepatic uptake: function, expression, and pharmacogenetics. Gastroenterology. 2006 May;130(6):1793-806.
90 Human organic anion-transporting polypeptide OATP-A (SLC21A3) acts in concert with P-glycoprotein and multidrug resistance protein 2 in the vectorial transport of Saquinavir in Hep G2 cells. Mol Pharm. 2004 Jan 12;1(1):49-56.
91 Uptake of enalapril and expression of organic anion transporting polypeptide 1 in zonal, isolated rat hepatocytes. Drug Metab Dispos. 2000 Jul;28(7):801-6.
92 Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver. Gastroenterology. 1995 Oct;109(4):1274-82.
93 Identification of thyroid hormone transporters in humans: different molecules are involved in a tissue-specific manner. Endocrinology. 2001 May;142(5):2005-12.
94 Involvement of influx and efflux transport systems in gastrointestinal absorption of celiprolol. J Pharm Sci. 2009 Jul;98(7):2529-39.
95 LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers. Gastroenterology. 2001 Jun;120(7):1689-99.
96 Effect of pregnane X receptor ligands on transport mediated by human OATP1B1 and OATP1B3. Eur J Pharmacol. 2008 Apr 14;584(1):57-65.
97 Influence of non-steroidal anti-inflammatory drugs on organic anion transporting polypeptide (OATP) 1B1- and OATP1B3-mediated drug transport. Drug Metab Dispos. 2011 Jun;39(6):1047-53.
98 Relevance of conserved lysine and arginine residues in transmembrane helices for the transport activity of organic anion transporting polypeptide 1B3. Br J Pharmacol. 2010 Feb 1;159(3):698-708.
99 Impact of OATP transporters on pharmacokinetics. Br J Pharmacol. 2009 Oct;158(3):693-705.
100 Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans. J Pharmacol Exp Ther. 2004 Oct;311(1):139-46.
101 Expression levels and activation of a PXR variant are directly related to drug resistance in osteosarcoma cell lines. Cancer. 2007 Mar 1;109(5):957-65.
102 Contribution of human hepatic cytochrome P450 isoforms to regioselective hydroxylation of steroid hormones. Xenobiotica. 1998 Jun;28(6):539-47.
103 Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: prominent roles for CYP3A and CYP2D6. J Pharmacol Exp Ther. 2004 Sep;310(3):1062-75.
104 Isoform-specific regulation of cytochromes P450 expression by estradiol and progesterone. Drug Metab Dispos. 2013 Feb;41(2):263-9.
105 Metabolic interactions between acetaminophen (paracetamol) and two flavonoids, luteolin and quercetin, through in-vitro inhibition studies. J Pharm Pharmacol. 2017 Dec;69(12):1762-1772.
106 Effects of morin on the pharmacokinetics of etoposide in rats. Biopharm Drug Dispos. 2007 Apr;28(3):151-6.
107 The metabolism of zidovudine by human liver microsomes in vitro: formation of 3'-amino-3'-deoxythymidine. Biochem Pharmacol. 1994 Jul 19;48(2):267-76.
108 Cytochrome P450 3A4-mediated interaction of diclofenac and quinidine. Drug Metab Dispos. 2000 Sep;28(9):1043-50.
109 Roles of cytochromes P450 1A2, 2A6, and 2C8 in 5-fluorouracil formation from tegafur, an anticancer prodrug, in human liver microsomes. Drug Metab Dispos. 2000 Dec;28(12):1457-63.
110 Effects of polyunsaturated fatty acids on prostaglandin synthesis and cyclooxygenase-mediated DNA adduct formation by heterocyclic aromatic amines in human adenocarcinoma colon cells. Mol Carcinog. 2004 Jul;40(3):180-8.
111 Endoxifen and other metabolites of tamoxifen inhibit human hydroxysteroid sulfotransferase 2A1 (hSULT2A1). Drug Metab Dispos. 2014 Nov;42(11):1843-50.
112 Cytochrome P450 1A2 (CYP1A2) activity and risk factors for breast cancer: a cross-sectional study. Breast Cancer Res. 2004;6(4):R352-65.
113 PharmGKB summary: pathways of acetaminophen metabolism at the therapeutic versus toxic doses. Pharmacogenet Genomics. 2015 Aug;25(8):416-26.
114 The influence of metabolic gene polymorphisms on urinary 1-hydroxypyrene concentrations in Chinese coke oven workers. Sci Total Environ. 2007 Aug 1;381(1-3):38-46.
115 Identification of P450 enzymes involved in metabolism of verapamil in humans. Naunyn Schmiedebergs Arch Pharmacol. 1993 Sep;348(3):332-7.
116 Metabolism and metabolic inhibition of xanthotoxol in human liver microsomes. Evid Based Complement Alternat Med. 2016;2016:5416509.
117 Ontogeny and sorafenib metabolism. Clin Cancer Res. 2012 Oct 15;18(20):5788-95.
118 Inhibitory effects of anticancer drugs on dextromethorphan-O-demethylase activity in human liver microsomes. Cancer Chemother Pharmacol. 1993;32(6):491-5.
119 Effect of genetic polymorphism on the metabolism of endogenous neuroactive substances, progesterone and p-tyramine, catalyzed by CYP2D6. Brain Res Mol Brain Res. 2004 Oct 22;129(1-2):117-23.
120 CYP2D6 polymorphisms and tamoxifen metabolism: clinical relevance. Curr Oncol Rep. 2010 Jan;12(1):7-15.
121 Inhibition of cytochrome P450 2D6: structure-activity studies using a series of quinidine and quinine analogues. Chem Res Toxicol. 2003 Apr;16(4):450-9.
122 Effects of propofol on human hepatic microsomal cytochrome P450 activities. Xenobiotica. 1998 Sep;28(9):845-53.
123 Pharmacogenetics of schizophrenia. Am J Med Genet. 2000 Spring;97(1):98-106.
124 Roles of CYP2A6 and CYP2B6 in nicotine C-oxidation by human liver microsomes. Arch Toxicol. 1999 Mar;73(2):65-70.
125 Structure-activity relationship for human cytochrome P450 substrates and inhibitors. Drug Metab Rev. 2002 Feb-May;34(1-2):69-82.
126 Bioactivation of the tricyclic antidepressant amitriptyline and its metabolite nortriptyline to arene oxide intermediates in human liver microsomes and recombinant P450s. Chem Biol Interact. 2008 May 9;173(1):59-67.
127 Drug related genetic polymorphisms affecting adverse reactions to methotrexate, vinblastine, doxorubicin and cisplatin in patients with urothelial cancer. J Urol. 2008 Dec;180(6):2389-95.
128 Human prostate CYP3A5: identification of a unique 5'-untranslated sequence and characterization of purified recombinant protein. Biochem Biophys Res Commun. 1999 Jul 14;260(3):676-81.
129 Polymorphisms in cytochrome P4503A5 (CYP3A5) may be associated with race and tumor characteristics, but not metabolism and side effects of tamoxifen in breast cancer patients. Cancer Lett. 2005 Jan 10;217(1):61-72.
130 Induction of hepatic CYP2E1 by a subtoxic dose of acetaminophen in rats: increase in dichloromethane metabolism and carboxyhemoglobin elevation. Drug Metab Dispos. 2007 Oct;35(10):1754-8.
131 Urinary 6 beta-hydroxycortisol excretion in rheumatoid arthritis. Br J Rheumatol. 1997 Jan;36(1):54-8.
132 Kinetics and regulation of cytochrome P450-mediated etoposide metabolism. Drug Metab Dispos. 2004 Sep;32(9):993-1000.
133 Differential mechanism-based inhibition of CYP3A4 and CYP3A5 by verapamil. Drug Metab Dispos. 2005 May;33(5):664-71.
134 16Alpha-hydroxylation of estrone by human cytochrome P4503A4/5. Carcinogenesis. 1998 May;19(5):867-72.
135 The role of cytochrome P450 3A (CYP3A) isoform(s) in oxidative metabolism of testosterone and benzphetamine in human adult and fetal liver. J Steroid Biochem Mol Biol. 1993 Jan;44(1):61-7.
136 Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448.
137 Prediction of cytochrome P450 3A inhibition by verapamil enantiomers and their metabolites. Drug Metab Dispos. 2004 Feb;32(2):259-66.
138 The role of human cytochrome P450 enzymes in the formation of 2-hydroxymetronidazole: CYP2A6 is the high affinity (low Km) catalyst. Drug Metab Dispos. 2013 Sep;41(9):1686-94.
139 Drug Development and Drug Interactions: Table of Substrates, Inhibitors and Inducers.
140 Differential expression and function of CYP2C isoforms in human intestine and liver. Pharmacogenetics. 2003 Sep;13(9):565-75.
141 Analysis of human cytochrome P450 2C8 substrate specificity using a substrate pharmacophore and site-directed mutants. Biochemistry. 2004 Dec 14;43(49):15379-92.
142 Interaction of sorafenib and cytochrome P450 isoenzymes in patients with advanced melanoma: a phase I/II pharmacokinetic interaction study. Cancer Chemother Pharmacol. 2011 Nov;68(5):1111-8.
143 PharmGKB summary: mycophenolic acid pathway. Pharmacogenet Genomics. 2014 Jan;24(1):73-9.
144 Possible involvement of multiple human cytochrome P450 isoforms in the liver metabolism of propofol. Br J Anaesth. 1998 Jun;80(6):788-95.
145 Influence of CYP2C8 polymorphisms on the hydroxylation metabolism of paclitaxel, repaglinide and ibuprofen enantiomers in vitro. Biopharm Drug Dispos. 2013 Jul;34(5):278-87.
146 Progesterone and testosterone hydroxylation by cytochromes P450 2C19, 2C9, and 3A4 in human liver microsomes. Arch Biochem Biophys. 1997 Oct 1;346(1):161-9.
147 Tamoxifen inhibits cytochrome P450 2C9 activity in breast cancer patients. J Chemother. 2006 Aug;18(4):421-4.
148 Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms. Endocrinology. 2003 Aug;144(8):3382-98.
149 Drug interactions with calcium channel blockers: possible involvement of metabolite-intermediate complexation with CYP3A. Drug Metab Dispos. 2000 Feb;28(2):125-30.
150 New insights into the structural features and functional relevance of human cytochrome P450 2C9. Part I. Curr Drug Metab. 2009 Dec;10(10):1075-126.
151 A potential role for the estrogen-metabolizing cytochrome P450 enzymes in human breast carcinogenesis. Breast Cancer Res Treat. 2003 Dec;82(3):191-7.
152 A mechanistic approach to antiepileptic drug interactions. Ann Pharmacother. 1998 May;32(5):554-63.
153 In vitro comparative inhibition profiles of major human drug metabolising cytochrome P450 isozymes (CYP2C9, CYP2D6 and CYP3A4) by HMG-CoA reductase inhibitors. Eur J Clin Pharmacol. 1996;50(3):209-15.
154 Peroxidative free radical formation and O-demethylation of etoposide(VP-16) and teniposide(VM-26). Biochem Biophys Res Commun. 1986 Feb 26;135(1):215-20.
155 The relative role of CYP3A4 and CYP3A5 in eplerenone metabolism. Toxicol Lett. 2019 Oct 15;315:9-13.
156 Characterization of the structural determinants required for potent mechanism-based inhibition of human cytochrome P450 1A1 by cannabidiol. Chem Biol Interact. 2014 May 25;215:62-8.
157 Retinoids activate the RXR/SXR-mediated pathway and induce the endogenous CYP3A4 activity in Huh7 human hepatoma cells. Toxicol Sci. 2006 Jul;92(1):51-60.
158 The novel azole R126638 is a selective inhibitor of ergosterol synthesis in Candida albicans, Trichophyton spp., and Microsporum canis. Antimicrob Agents Chemother. 2004 Sep;48(9):3272-8.
159 Application of higher throughput screening (HTS) inhibition assays to evaluate the interaction of antiparasitic drugs with cytochrome P450s. Drug Metab Dispos. 2001 Jan;29(1):30-5.
160 Cetirizine and loratadine-based antihistamines with 5-lipoxygenase inhibitory activity. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5591-4.
161 Mechanism-based inactivation of CYP3A by HIV protease inhibitors. J Pharmacol Exp Ther. 2005 Feb;312(2):583-91.
162 Studies of the toxicological potential of capsinoids, XIII: inhibitory effects of capsaicin and capsinoids on cytochrome P450 3A4 in human liver microsomes. Int J Toxicol. 2010 Mar;29(2 Suppl):22S-6S.
163 Investigation of the effects of axitinib on the pharmacokinetics of loperamide and its main metabolite N-demethylated loperamide in rats by UPLC-MS/MS. Chem Biol Interact. 2019 Sep 1;310:108744. doi: 10.1016/j.cbi.2019.108744. Epub 2019 Jul 9.
164 Contribution of CYP3A5 to hepatic and renal ifosfamide N-dechloroethylation. Drug Metab Dispos. 2005 Jul;33(7):1074-81. doi: 10.1124/dmd.104.002279. Epub 2005 Apr 8.
165 Use of mRNA expression to detect the induction of drug metabolising enzymes in rat and human hepatocytes. Toxicol Appl Pharmacol. 2009 Feb 15;235(1):86-96.
166 Induction of human cytochrome P450 3A enzymes in cultured placental cells by thalidomide and relevance to bioactivation and toxicity. J Toxicol Sci. 2017;42(3):343-348.
167 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
168 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
169 Induction of hepatic CYP3A enzymes by pregnancy-related hormones: studies in human hepatocytes and hepatic cell lines. Drug Metab Dispos. 2013 Feb;41(2):281-90.
170 Retinoic acid and its 4-oxo metabolites are functionally active in human skin cells in vitro. J Invest Dermatol. 2005 Jul;125(1):143-53.
171 Induction of CYP3As in HepG2 cells by several drugs. Association between induction of CYP3A4 and expression of glucocorticoid receptor. Biol Pharm Bull. 2003 Apr;26(4):510-7.
172 Human drug metabolism genes in parathion-and estrogen-treated breast cells. Int J Mol Med. 2007 Dec;20(6):875-81.
173 Dose- and time-dependent effects of phenobarbital on gene expression profiling in human hepatoma HepaRG cells. Toxicol Appl Pharmacol. 2009 Feb 1;234(3):345-60.
174 Transcriptional profiling of genes induced in the livers of patients treated with carbamazepine. Clin Pharmacol Ther. 2006 Nov;80(5):440-456.
175 Variability of CYP3A7 expression in human fetal liver. J Pharmacol Exp Ther. 2005 Aug;314(2):626-35. doi: 10.1124/jpet.105.086504. Epub 2005 Apr 21.
176 Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
177 Selective suppressions of human CYP3A forms, CYP3A5 and CYP3A7, by troglitazone in HepG2 cells. Drug Metab Pharmacokinet. 2002;17(1):42-6.
178 Examination of 209 drugs for inhibition of cytochrome P450 2C8. J Clin Pharmacol. 2005 Jan;45(1):68-78.
179 Identification of the polymorphically expressed CYP2C19 and the wild-type CYP2C9-ILE359 allele as low-Km catalysts of cyclophosphamide and ifosfamide activation. Pharmacogenetics. 1997 Jun;7(3):211-21.
180 Essential requirements for substrate binding affinity and selectivity toward human CYP2 family enzymes. Arch Biochem Biophys. 2003 Jan 1;409(1):32-44.
181 Differential inhibition of human CYP2C8 and molecular docking interactions elicited by sorafenib and its major N-oxide metabolite. Chem Biol Interact. 2021 Apr 1;338:109401. doi: 10.1016/j.cbi.2021.109401. Epub 2021 Feb 5.
182 Dabrafenib inhibits ABCG2 and cytochrome P450 isoenzymes; potential implications for combination anticancer therapy. Toxicol Appl Pharmacol. 2022 Jan 1;434:115797. doi: 10.1016/j.taap.2021.115797. Epub 2021 Nov 13.
183 Localization of breast cancer resistance protein (Bcrp) in endocrine organs and inhibition of its transport activity by steroid hormones. Cell Tissue Res. 2012 Aug;349(2):551-63. doi: 10.1007/s00441-012-1417-5. Epub 2012 May 13.
184 Pharmacogenetics of ABCG2 and adverse reactions to gefitinib. J Natl Cancer Inst. 2006 Dec 6;98(23):1739-42.
185 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
186 ABCG2 polymorphism is associated with the low-density lipoprotein cholesterol response to rosuvastatin. Clin Pharmacol Ther. 2010 May;87(5):558-62.
187 Ciprofloxacin mediates cancer stem cell phenotypes in lung cancer cells through caveolin-1-dependent mechanism. Chem Biol Interact. 2016 Apr 25;250:1-11.
188 Proteomic identification of differentially expressed proteins associated with the multiple drug resistance in methotrexate-resistant human breast cancer cells. Int J Oncol. 2014 Jul;45(1):448-58.
189 Activation of beta-catenin signalling by GSK-3 inhibition increases p-glycoprotein expression in brain endothelial cells. J Neurochem. 2008 Aug;106(4):1855-65. doi: 10.1111/j.1471-4159.2008.05537.x. Epub 2008 Jul 4.
190 Differential gene expression in human hepatocyte cell lines exposed to the antiretroviral agent zidovudine. Arch Toxicol. 2014 Mar;88(3):609-23. doi: 10.1007/s00204-013-1169-3. Epub 2013 Nov 30.
191 Folate deprivation induces BCRP (ABCG2) expression and mitoxantrone resistance in Caco-2 cells. Int J Cancer. 2008 Oct 1;123(7):1712-20.
192 Characteristics of P388/VMDRC.04, a simple, sensitive model for studying P-glycoprotein antagonists. Cancer Res. 1994 Feb 1;54(3):730-7.
193 Michaelis-Menten kinetic analysis of drugs of abuse to estimate their affinity to human P-glycoprotein. Toxicol Lett. 2013 Feb 27;217(2):137-42. doi: 10.1016/j.toxlet.2012.12.012. Epub 2012 Dec 27.
194 Editor's Highlight: PlacentalDisposition and Effects of Crizotinib: An Ex Vivo Study in the Isolated Dual-Side Perfused Human Cotyledon. Toxicol Sci. 2017 Jun 1;157(2):500-509. doi: 10.1093/toxsci/kfx063.
195 Functional evaluation of polymorphisms in the human ABCB1 gene and the impact on clinical responses of antiepileptic drugs. Pharmacogenet Genomics. 2008 May;18(5):390-402. doi: 10.1097/FPC.0b013e3282f85e36.
196 Cepharanthine potently enhances the sensitivity of anticancer agents in K562 cells. Cancer Sci. 2005 Jun;96(6):372-6. doi: 10.1111/j.1349-7006.2005.00057.x.
197 Clinical pharmacokinetic monitoring of itraconazole is warranted in only a subset of patients. Ther Drug Monit. 2005 Jun;27(3):322-33. doi: 10.1097/01.ftd.0000150135.22645.ea.
198 Evaluation of antipsychotic drugs as inhibitors of multidrug resistance transporter P-glycoprotein. Psychopharmacology (Berl). 2006 Sep;187(4):415-23. doi: 10.1007/s00213-006-0437-9. Epub 2006 Jun 30.
199 Actions of the selective protein kinase C inhibitor PKC412 on B-chronic lymphocytic leukemia cells in vitro. Haematologica. 2002 Feb;87(2):167-76.
200 Characterization of the ATPase activity of the Mr 170,000 to 180,000 membrane glycoprotein (P-glycoprotein) associated with multidrug resistance in K562/ADM cells. Cancer Res. 1988 Sep 1;48(17):4926-32.
201 Metabolomics of oxidative stress: Nrf2 independent depletion of NAD or increases of sugar alcohols. Toxicol Appl Pharmacol. 2022 May 1;442:115949. doi: 10.1016/j.taap.2022.115949. Epub 2022 Feb 25.
202 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
203 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
204 Comparative gene expression analysis of a chronic myelogenous leukemia cell line resistant to cyclophosphamide using oligonucleotide arrays and response to tyrosine kinase inhibitors. Leuk Res. 2007 Nov;31(11):1511-20.
205 Survival of retinal pigment epithelium after exposure to prolonged oxidative injury: a detailed gene expression and cellular analysis. Invest Ophthalmol Vis Sci. 2004 Oct;45(10):3767-77.
206 The enzymatic activity of human aldehyde dehydrogenases 1A2 and 2 (ALDH1A2 and ALDH2) is detected by Aldefluor, inhibited by diethylaminobenzaldehyde and has significant effects on cell proliferation and drug resistance. Chem Biol Interact. 2012 Jan 5;195(1):52-60.
207 Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
208 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
209 Differences in the activities of resveratrol and ascorbic acid in protection of ethanol-induced oxidative DNA damage in human peripheral lymphocytes. Food Chem Toxicol. 2012 Feb;50(2):168-74.
210 Ribavirin inhibits the growth and ascites formation of hepatocellular carcinoma through downregulation of type I CARM1 and type II PRMT5. Toxicol Appl Pharmacol. 2022 Jan 15;435:115829. doi: 10.1016/j.taap.2021.115829. Epub 2021 Dec 14.
211 Benzodithiophenes potentiate differentiation of acute promyelocytic leukemia cells by lowering the threshold for ligand-mediated corepressor/coactivator exchange with retinoic acid receptor alpha and enhancing changes in all-trans-retinoic acid-regulated gene expression. Cancer Res. 2005 Sep 1;65(17):7856-65. doi: 10.1158/0008-5472.CAN-05-1056.
212 Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May;1(3):177-87.
213 Differential Response of Glioma Stem Cells to Arsenic Trioxide Therapy Is Regulated by MNK1 and mRNA Translation. Mol Cancer Res. 2018 Jan;16(1):32-46. doi: 10.1158/1541-7786.MCR-17-0397. Epub 2017 Oct 17.
214 The p38 MAPK pathway mediates aryl propionic acid induced messenger rna stability of p75 NTR in prostate cancer cells. Cancer Res. 2007 Dec 1;67(23):11402-10. doi: 10.1158/0008-5472.CAN-07-1792.
215 The effect of quercetin nanoparticle on cervical cancer progression by inducing apoptosis, autophagy and anti-proliferation via JAK2 suppression. Biomed Pharmacother. 2016 Aug;82:595-605. doi: 10.1016/j.biopha.2016.05.029. Epub 2016 Jun 9.
216 Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
217 Low doses of cisplatin induce gene alterations, cell cycle arrest, and apoptosis in human promyelocytic leukemia cells. Biomark Insights. 2016 Aug 24;11:113-21.
218 Cannabidiol Displays Proteomic Similarities to Antipsychotics in Cuprizone-Exposed Human Oligodendrocytic Cell Line MO3.13. Front Mol Neurosci. 2021 May 28;14:673144. doi: 10.3389/fnmol.2021.673144. eCollection 2021.
219 Screening autism-associated environmental factors in differentiating human neural progenitors with fractional factorial design-based transcriptomics. Sci Rep. 2023 Jun 29;13(1):10519. doi: 10.1038/s41598-023-37488-0.
220 Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
221 Changes in gene expression profiles of multiple myeloma cells induced by arsenic trioxide (ATO): possible mechanisms to explain ATO resistance in vivo. Br J Haematol. 2005 Mar;128(5):636-44.
222 Chronic ethanol exposure increases goosecoid (GSC) expression in human embryonic carcinoma cell differentiation. J Appl Toxicol. 2014 Jan;34(1):66-75.
223 Single-cell Transcriptome Mapping Identifies Common and Cell-type Specific Genes Affected by Acute Delta9-tetrahydrocannabinol in Humans. Sci Rep. 2020 Feb 26;10(1):3450. doi: 10.1038/s41598-020-59827-1.
224 Zoledronate dysregulates fatty acid metabolism in renal tubular epithelial cells to induce nephrotoxicity. Arch Toxicol. 2018 Jan;92(1):469-485.
225 Gene expression profiling of 30 cancer cell lines predicts resistance towards 11 anticancer drugs at clinically achieved concentrations. Int J Cancer. 2006 Apr 1;118(7):1699-712. doi: 10.1002/ijc.21570.
226 Proteomic analysis of the cellular response to a potent sensitiser unveils the dynamics of haptenation in living cells. Toxicology. 2020 Dec 1;445:152603. doi: 10.1016/j.tox.2020.152603. Epub 2020 Sep 28.
227 Endoplasmic reticulum stress impairs insulin signaling through mitochondrial damage in SH-SY5Y cells. Neurosignals. 2012;20(4):265-80.
228 p16-Cdk4-Rb axis controls sensitivity to a cyclin-dependent kinase inhibitor PD0332991 in glioblastoma xenograft cells. Neuro Oncol. 2012 Jul;14(7):870-81. doi: 10.1093/neuonc/nos114. Epub 2012 Jun 18.
229 In vitro effects of cannabidiol and its main metabolites in mouse and human Sertoli cells. Food Chem Toxicol. 2022 Jan;159:112722. doi: 10.1016/j.fct.2021.112722. Epub 2021 Dec 3.
230 Selenite and selenomethionine promote HL-60 cell cycle progression. J Nutr. 2002 Apr;132(4):674-9. doi: 10.1093/jn/132.4.674.
231 JNK1 is required for sulindac-mediated inhibition of cell proliferation and induction of apoptosis in vitro and in vivo. Eur J Pharmacol. 2007 Apr 10;560(2-3):95-100. doi: 10.1016/j.ejphar.2007.01.020. Epub 2007 Jan 19.
232 Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells. Tumour Biol. 2011 Oct;32(5):965-76.
233 Simvastatin inhibits cell growth and induces apoptosis and G0/G1 cell cycle arrest in hepatic cancer cells. Int J Mol Med. 2010 Nov;26(5):735-41. doi: 10.3892/ijmm_00000520.
234 A gene signature-based approach identifies thioridazine as an inhibitor of phosphatidylinositol-3'-kinase (PI3K)/AKT pathway in ovarian cancer cells. Gynecol Oncol. 2011 Jan;120(1):121-7. doi: 10.1016/j.ygyno.2010.10.003. Epub 2010 Oct 29.
235 Inhibition of prostate cancer cell colony formation by the flavonoid quercetin correlates with modulation of specific regulatory genes. Clin Diagn Lab Immunol. 2004 Jan;11(1):63-9. doi: 10.1128/cdli.11.1.63-69.2004.
236 Effects of ciglitazone and troglitazone on the proliferation of human stomach cancer cells. World J Gastroenterol. 2009 Jan 21;15(3):310-20.
237 Cannabidiol and Oxygen-Ozone Combination Induce Cytotoxicity in Human Pancreatic Ductal Adenocarcinoma Cell Lines. Cancers (Basel). 2020 Sep 27;12(10):2774. doi: 10.3390/cancers12102774.
238 G2 delay induced by nitrogen mustard in human cells affects cyclin A/cdk2 and cyclin B1/cdc2-kinase complexes differently. J Biol Chem. 1993 Apr 15;268(11):8298-308.
239 Estrogen regulation in human breast cancer cells of new downstream gene targets involved in estrogen metabolism, cell proliferation and cell transformation. J Mol Endocrinol. 2004 Apr;32(2):397-414.
240 Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells. Cancer Res. 2002 Nov 1;62(21):6246-54.
241 Ribavirin inhibits colorectal cancer growth by downregulating PRMT5 expression and H3R8me2s and H4R3me2s accumulation. Toxicol Appl Pharmacol. 2021 Mar 15;415:115450. doi: 10.1016/j.taap.2021.115450. Epub 2021 Feb 9.
242 Sulindac induces specific degradation of the HPV oncoprotein E7 and causes growth arrest and apoptosis in cervical carcinoma cells. Cancer Lett. 2007 Jan 8;245(1-2):103-11. doi: 10.1016/j.canlet.2005.12.034. Epub 2006 Feb 20.
243 Methotrexate modulates folate phenotype and inflammatory profile in EA.hy 926 cells. Eur J Pharmacol. 2014 Jun 5;732:60-7.
244 Simvastatin inactivates beta1-integrin and extracellular signal-related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells. Cancer Sci. 2007 Jun;98(6):890-9.
245 CDK4/6 inhibition provides a potent adjunct to Her2-targeted therapies in preclinical breast cancer models. Genes Cancer. 2014 Jul;5(7-8):261-72. doi: 10.18632/genesandcancer.24.
246 Rapamycin sensitizes multiple myeloma cells to apoptosis induced by dexamethasone. Blood. 2004 Apr 15;103(8):3138-47. doi: 10.1182/blood-2003-05-1543. Epub 2003 Dec 24.
247 Antidepressant drug sertraline modulates AMPK-MTOR signaling-mediated autophagy via targeting mitochondrial VDAC1 protein. Autophagy. 2021 Oct;17(10):2783-2799. doi: 10.1080/15548627.2020.1841953. Epub 2020 Nov 9.
248 EGFR tyrosine kinase inhibitors activate autophagy as a cytoprotective response in human lung cancer cells. PLoS One. 2011;6(6):e18691. doi: 10.1371/journal.pone.0018691. Epub 2011 Jun 2.
249 Oxidative stress induces parallel autophagy and mitochondria dysfunction in human glioma U251 cells. Toxicol Sci. 2009 Aug;110(2):376-88. doi: 10.1093/toxsci/kfp101. Epub 2009 May 18.
250 Combination small molecule MEK and PI3K inhibition enhances uveal melanoma cell death in a mutant GNAQ- and GNA11-dependent manner. Clin Cancer Res. 2012 Aug 15;18(16):4345-55. doi: 10.1158/1078-0432.CCR-11-3227. Epub 2012 Jun 25.
251 Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105.
252 SU5416 inhibited VEGF and HIF-1alpha expression through the PI3K/AKT/p70S6K1 signaling pathway. Biochem Biophys Res Commun. 2004 Nov 12;324(2):471-80. doi: 10.1016/j.bbrc.2004.09.082.
253 Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis. Biochem Pharmacol. 2004 Dec 1;68(11):2177-86.
254 D-glucosamine down-regulates HIF-1alpha through inhibition of protein translation in DU145 prostate cancer cells. Biochem Biophys Res Commun. 2009 Apr 24;382(1):96-101. doi: 10.1016/j.bbrc.2009.02.129. Epub 2009 Feb 28.
255 Arsenic trioxide inhibits translation of mRNA of bcr-abl, resulting in attenuation of Bcr-Abl levels and apoptosis of human leukemia cells. Cancer Res. 2003 Nov 15;63(22):7950-8.
256 Characterization of arsenic trioxide resistant clones derived from Jurkat leukemia T cell line: focus on PI3K/Akt signaling pathway. Chem Biol Interact. 2013 Oct 5;205(3):198-211. doi: 10.1016/j.cbi.2013.07.011. Epub 2013 Aug 2.
257 Cisplatin transiently up-regulates hHR23 expression through enhanced translational efficiency in A549 adenocarcinoma cells. Toxicol Lett. 2011 Sep 10;205(3):341-50. doi: 10.1016/j.toxlet.2011.06.028. Epub 2011 Jul 2.
258 Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
259 Gene expression analysis of precision-cut human liver slices indicates stable expression of ADME-Tox related genes. Toxicol Appl Pharmacol. 2011 May 15;253(1):57-69.
260 Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
261 Phosphoproteomics reveals resveratrol-dependent inhibition of Akt/mTORC1/S6K1 signaling. J Proteome Res. 2014 Dec 5;13(12):5734-42. doi: 10.1021/pr500714a. Epub 2014 Oct 29.
262 Repression of Kisspeptin1 weakens hydrogen peroxide-caused injury in HTR8 cells via adjusting PI3K/AKT/mTOR pathway. J Biochem Mol Toxicol. 2020 May;34(5):e22461. doi: 10.1002/jbt.22461. Epub 2020 Feb 11.
263 Anticarcinogenic action of quercetin by downregulation of phosphatidylinositol 3-kinase (PI3K) and protein kinase C (PKC) via induction of p53 in hepatocellular carcinoma (HepG2) cell line. Mol Biol Rep. 2015 Sep;42(9):1419-29. doi: 10.1007/s11033-015-3921-7. Epub 2015 Aug 27.
264 Retinoic acid receptor alpha amplifications and retinoic acid sensitivity in breast cancers. Clin Breast Cancer. 2013 Oct;13(5):401-8.
265 Robustness testing and optimization of an adverse outcome pathway on cholestatic liver injury. Arch Toxicol. 2020 Apr;94(4):1151-1172. doi: 10.1007/s00204-020-02691-9. Epub 2020 Mar 10.
266 Arsenic trioxide reduces the expression of E2F1, cyclin E, and phosphorylation of PI3K signaling molecules in acute leukemia cells. Environ Toxicol. 2021 Sep;36(9):1785-1792. doi: 10.1002/tox.23299. Epub 2021 May 27.
267 Lunasin, a novel seed peptide, sensitizes human breast cancer MDA-MB-231 cells to aspirin-arrested cell cycle and induced apoptosis. Chem Biol Interact. 2010 Jul 30;186(2):127-34. doi: 10.1016/j.cbi.2010.04.027. Epub 2010 May 21.
268 The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
269 Cantharidin suppresses gastric cancer cell migration/invasion by inhibiting the PI3K/Akt signaling pathway via CCAT1. Chem Biol Interact. 2020 Feb 1;317:108939. doi: 10.1016/j.cbi.2020.108939. Epub 2020 Jan 13.
270 Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells. Toxicol Sci. 2023 Feb 17;191(2):227-238. doi: 10.1093/toxsci/kfac131.
271 Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival. Cancer Res. 2006 Jun 1;66(11):5542-8. doi: 10.1158/0008-5472.CAN-05-4620.
272 Involvement of the p38 MAPK signaling pathway in S-phase cell-cycle arrest induced by Furazolidone in human hepatoma G2 cells. J Appl Toxicol. 2013 Dec;33(12):1500-5. doi: 10.1002/jat.2829. Epub 2012 Oct 30.
273 Thiazolidinediones inhibit proliferation of microvascular and macrovascular cells by a PPARgamma-independent mechanism. Diabetologia. 2005 Mar;48(3):586-94. doi: 10.1007/s00125-005-1672-z. Epub 2005 Feb 24.
274 Retinoid targeting of different D-type cyclins through distinct chemopreventive mechanisms. Cancer Res. 2005 Jul 15;65(14):6476-83. doi: 10.1158/0008-5472.CAN-05-0370.
275 Effects of chlorpromazine with and without UV irradiation on gene expression of HepG2 cells. Mutat Res. 2005 Aug 4;575(1-2):47-60. doi: 10.1016/j.mrfmmm.2005.03.002. Epub 2005 Apr 26.
276 Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
277 DNA array analysis of the effects of aspirin on colon cancer cells: involvement of Rac1. Carcinogenesis. 2004 Jul;25(7):1293-8.
278 THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders. Transl Psychiatry. 2018 Apr 25;8(1):89. doi: 10.1038/s41398-018-0137-3.
279 Inhibition of cholesterol metabolism underlies synergy between mTOR pathway inhibition and chloroquine in bladder cancer cells. Oncogene. 2016 Aug 25;35(34):4518-28. doi: 10.1038/onc.2015.511. Epub 2016 Feb 8.
280 Nicotine-induced survival signaling in lung cancer cells is dependent on their p53 status while its down-regulation by curcumin is independent. Mol Cancer. 2010 Aug 20;9:220.
281 Role of miRNA in the regulation of cannabidiol-mediated apoptosis in neuroblastoma cells. Oncotarget. 2019 Jan 1;10(1):45-59. doi: 10.18632/oncotarget.26534. eCollection 2019 Jan 1.
282 -Carotene Induces Apoptosis in Human Esophageal Squamous Cell Carcinoma Cell Lines via the Cav-1/AKT/NF-B Signaling Pathway. J Biochem Mol Toxicol. 2016 Mar;30(3):148-57. doi: 10.1002/jbt.21773. Epub 2016 Jan 6.
283 Dihydromyricetin suppresses tumor growth via downregulation of the EGFR/Akt/survivin signaling pathway. J Biochem Mol Toxicol. 2023 Jun;37(6):e23328. doi: 10.1002/jbt.23328. Epub 2023 Feb 19.
284 Effect of toll-like receptor 7 and 9 targeted therapy to prevent the development of hepatocellular carcinoma. Liver Int. 2015 Mar;35(3):1063-76. doi: 10.1111/liv.12626. Epub 2014 Jul 30.
285 Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
286 Low-expressional IGF1 mediated methimazole-induced liver developmental toxicity in fetal mice. Toxicology. 2018 Sep 1;408:70-79. doi: 10.1016/j.tox.2018.07.004. Epub 2018 Jul 7.
287 Ribavirin augments doxorubicin's efficacy in human hepatocellular carcinoma through inhibiting doxorubicin-induced eIF4E activation. J Biochem Mol Toxicol. 2018 Jan;32(1). doi: 10.1002/jbt.22007. Epub 2017 Nov 7.
288 Neuronal and cardiac toxicity of pharmacological compounds identified through transcriptomic analysis of human pluripotent stem cell-derived embryoid bodies. Toxicol Appl Pharmacol. 2021 Dec 15;433:115792. doi: 10.1016/j.taap.2021.115792. Epub 2021 Nov 3.
289 Involvement of pregnane X receptor in the impaired glucose utilization induced by atorvastatin in hepatocytes. Biochem Pharmacol. 2016 Jan 15;100:98-111.
290 Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
291 Folic acid supplementation dysregulates gene expression in lymphoblastoid cells--implications in nutrition. Biochem Biophys Res Commun. 2011 Sep 9;412(4):688-92. doi: 10.1016/j.bbrc.2011.08.027. Epub 2011 Aug 16.
292 Epigenetic changes in individuals with arsenicosis. Chem Res Toxicol. 2011 Feb 18;24(2):165-7. doi: 10.1021/tx1004419. Epub 2011 Feb 4.
293 17-Estradiol Activates HSF1 via MAPK Signaling in ER-Positive Breast Cancer Cells. Cancers (Basel). 2019 Oct 11;11(10):1533. doi: 10.3390/cancers11101533.
294 Resveratrol potentiates glucose-stimulated insulin secretion in INS-1E beta-cells and human islets through a SIRT1-dependent mechanism. J Biol Chem. 2011 Feb 25;286(8):6049-60. doi: 10.1074/jbc.M110.176842. Epub 2010 Dec 16.
295 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
296 eIF4E is a critical regulator of human papillomavirus (HPV)-immortalized cervical epithelial (H8) cell growth induced by nicotine. Toxicology. 2019 May 1;419:1-10. doi: 10.1016/j.tox.2019.02.017. Epub 2019 Mar 2.
297 Transcriptomic Analysis of Stem Cells Treated with Moringin or Cannabidiol: Analogies and Differences in Inflammation Pathways. Int J Mol Sci. 2019 Nov 30;20(23):6039. doi: 10.3390/ijms20236039.
298 Establishment of a 13 genes-based molecular prediction score model to discriminate the neurotoxic potential of food relevant-chemicals. Toxicol Lett. 2022 Feb 1;355:1-18. doi: 10.1016/j.toxlet.2021.10.013. Epub 2021 Nov 5.
299 Quercetin inhibits angiogenesis mediated human prostate tumor growth by targeting VEGFR- 2 regulated AKT/mTOR/P70S6K signaling pathways. PLoS One. 2012;7(10):e47516. doi: 10.1371/journal.pone.0047516. Epub 2012 Oct 18.
300 A comprehensive analysis of Wnt/beta-catenin signaling pathway-related genes and crosstalk pathways in the treatment of As2O3 in renal cancer. Ren Fail. 2018 Nov;40(1):331-339.
301 Hydroquinone-induced endoplasmic reticulum stress affects TK6 cell autophagy and apoptosis via ATF6-mTOR. Environ Toxicol. 2023 Aug;38(8):1874-1890. doi: 10.1002/tox.23814. Epub 2023 May 6.
302 Neuroprotective effects of glucomoringin-isothiocyanate against H(2)O(2)-Induced cytotoxicity in neuroblastoma (SH-SY5Y) cells. Neurotoxicology. 2019 Dec;75:89-104. doi: 10.1016/j.neuro.2019.09.008. Epub 2019 Sep 12.
303 Arsenic trioxide inhibits CXCR4-mediated metastasis by interfering miR-520h/PP2A/NF-B signaling in cervical cancer. Ann Surg Oncol. 2014 Dec;21 Suppl 4:S687-95. doi: 10.1245/s10434-014-3812-5. Epub 2014 Jul 22.
304 p38 MAPK/PP2Ac/TTP pathway on the connection of TNF- and caspases activation on hydroquinone-induced apoptosis. Carcinogenesis. 2013 Apr;34(4):818-27. doi: 10.1093/carcin/bgs409. Epub 2013 Jan 3.
305 Effects of metformin and pioglitazone combination on apoptosis and AMPK/mTOR signaling pathway in human anaplastic thyroid cancer cells. J Biochem Mol Toxicol. 2020 Oct;34(10):e22547. doi: 10.1002/jbt.22547. Epub 2020 Jun 26.
306 CREB/Sp1-mediated MCL1 expression and NFB-mediated ABCB1 expression modulate the cytotoxicity of daunorubicin in chronic myeloid leukemia cells. Toxicol Appl Pharmacol. 2022 Jan 15;435:115847. doi: 10.1016/j.taap.2021.115847. Epub 2021 Dec 25.
307 Transcriptional profiling in the human prefrontal cortex: evidence for two activational states associated with cocaine abuse. Pharmacogenomics J. 2003;3(1):27-40.
308 Methylation status of CpG islands flanking a cAMP response element motif on the protein phosphatase 2Ac alpha promoter determines CREB binding and activity. J Immunol. 2009 Feb 1;182(3):1500-8. doi: 10.4049/jimmunol.182.3.1500.
309 Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: application to acetaminophen injury. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):270-80.
310 "Minimalist" cyclopropene-containing photo-cross-linkers suitable for live-cell imaging and affinity-based protein labeling. J Am Chem Soc. 2014 Jul 16;136(28):9990-8. doi: 10.1021/ja502780z. Epub 2014 Jul 3.
311 Frenolicin B Targets Peroxiredoxin 1 and Glutaredoxin 3 to Trigger ROS/4E-BP1-Mediated Antitumor Effects. Cell Chem Biol. 2019 Mar 21;26(3):366-377.e12. doi: 10.1016/j.chembiol.2018.11.013. Epub 2019 Jan 17.
312 Arsenic trioxide potentiates the anti-cancer activities of sorafenib against hepatocellular carcinoma by inhibiting Akt activation. Tumour Biol. 2015 Apr;36(4):2323-34. doi: 10.1007/s13277-014-2839-3. Epub 2014 Nov 22.
313 Keratinocyte-derived IL-36gama plays a role in hydroquinone-induced chemical leukoderma through inhibition of melanogenesis in human epidermal melanocytes. Arch Toxicol. 2019 Aug;93(8):2307-2320.
314 Androgen receptor-mTOR crosstalk is regulated by testosterone availability: implication for prostate cancer cell survival. Anticancer Res. 2010 Oct;30(10):3895-901.
315 The neuroprotective action of the mood stabilizing drugs lithium chloride and sodium valproate is mediated through the up-regulation of the homeodomain protein Six1. Toxicol Appl Pharmacol. 2009 Feb 15;235(1):124-34.
316 Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicol Sci. 2010 Dec; 118(2):485-500.
317 Early identification of clinically relevant drug interactions with the human bile salt export pump (BSEP/ABCB11). Toxicol Sci. 2013 Dec;136(2):328-43.
318 Omics-based responses induced by bosentan in human hepatoma HepaRG cell cultures. Arch Toxicol. 2018 Jun;92(6):1939-1952.
319 Evaluating the Role of Multidrug Resistance Protein 3 (MDR3) Inhibition in Predicting Drug-Induced Liver Injury Using 125 Pharmaceuticals. Chem Res Toxicol. 2017 May 15;30(5):1219-1229. doi: 10.1021/acs.chemrestox.7b00048. Epub 2017 May 4.
320 A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicol Sci. 2013 Nov;136(1):216-41.
321 Docosahexaenoic acid regulates gene expression in HUVEC cells treated with polycyclic aromatic hydrocarbons. Toxicol Lett. 2015 Jul 16;236(2):75-81.
322 Etoposide induces necrosis through p53-mediated antiapoptosis in human kidney proximal tubule cells. Toxicol Sci. 2015 Nov;148(1):204-19.
323 Conjugated linoleic acid, unlike other unsaturated fatty acids, strongly induces glutathione synthesis without any lipoperoxidation. Br J Nutr. 2006 Nov;96(5):811-9.
324 COX-2 and PPAR-gama confer cannabidiol-induced apoptosis of human lung cancer cells. Mol Cancer Ther. 2013 Jan;12(1):69-82.
325 Mitochondrial involvement in schizophrenia and other functional psychoses. Neurochem Res. 1996 Sep;21(9):995-1004.
326 Immunomodulatory effect of selective serotonin reuptake inhibitors (SSRIs) on human T lymphocyte function and gene expression. Eur Neuropsychopharmacol. 2007 Dec;17(12):774-80.
327 Stimulation of cyclooxygenase-2 expression by bone-derived transforming growth factor-beta enhances bone metastases in breast cancer. Cancer Res. 2006 Feb 15;66(4):2067-73.
328 Arsenite and cadmium promote the development of mammary tumors. Carcinogenesis. 2020 Jul 14;41(7):1005-1014. doi: 10.1093/carcin/bgz176.
329 An in vitro coculture system of human peripheral blood mononuclear cells with hepatocellular carcinoma-derived cells for predicting drug-induced liver injury. Arch Toxicol. 2021 Jan;95(1):149-168. doi: 10.1007/s00204-020-02882-4. Epub 2020 Aug 20.
330 A2E selectively induces cox-2 in ARPE-19 and human neural cells. Curr Eye Res. 2006 Mar;31(3):259-63.
331 Utilization of CDKN1A/p21 gene for class discrimination of DNA damage-induced clastogenicity. Toxicology. 2014 Jan 6;315:8-16. doi: 10.1016/j.tox.2013.10.009. Epub 2013 Nov 6.
332 Regulation of DR-5 protein and mitochondrial transmembrane potential by gemcitabine, a possible mechanism of gemcitabine-enhanced TRAIL-induced apoptosis. Oncol Rep. 2007 Sep;18(3):523-9.
333 Cannabidiol Modulates the Immunophenotype and Inhibits the Activation of the Inflammasome in Human Gingival Mesenchymal Stem Cells. Front Physiol. 2016 Nov 24;7:559. doi: 10.3389/fphys.2016.00559. eCollection 2016.
334 Amiodarone sensitizes human glioma cells but not astrocytes to TRAIL-induced apoptosis via CHOP-mediated DR5 upregulation. Neuro Oncol. 2011 Mar;13(3):267-79. doi: 10.1093/neuonc/noq195. Epub 2011 Feb 3.
335 Novel functional view of the crocidolite asbestos-treated A549 human lung epithelial transcriptome reveals an intricate network of pathways with opposing functions. BMC Genomics. 2008 Aug 7;9:376.
336 Death receptor 5 regulation during selenium-mediated apoptosis in human prostate cancer cells. Cancer Biol Ther. 2002 May-Jun;1(3):287-90. doi: 10.4161/cbt.83.
337 Death receptor regulation and celecoxib-induced apoptosis in human lung cancer cells. J Natl Cancer Inst. 2004 Dec 1;96(23):1769-80. doi: 10.1093/jnci/djh322.
338 Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
339 Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
340 Label-free quantitative proteomic analysis identifies the oncogenic role of FOXA1 in BaP-transformed 16HBE cells. Toxicol Appl Pharmacol. 2020 Sep 15;403:115160. doi: 10.1016/j.taap.2020.115160. Epub 2020 Jul 25.
341 Quantitative phosphoproteomics reveal cellular responses from caffeine, coumarin and quercetin in treated HepG2 cells. Toxicol Appl Pharmacol. 2022 Aug 15;449:116110. doi: 10.1016/j.taap.2022.116110. Epub 2022 Jun 7.
342 DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.
343 Gene expression profile analysis of gallic acid-induced cell death process. Sci Rep. 2021 Aug 18;11(1):16743. doi: 10.1038/s41598-021-96174-1.
344 Suppressed translation and ULK1 degradation as potential mechanisms of autophagy limitation under prolonged starvation. Autophagy. 2016 Nov;12(11):2085-2097. doi: 10.1080/15548627.2016.1226733. Epub 2016 Sep 14.
345 Cannabidiol induces antioxidant pathways in keratinocytes by targeting BACH1. Redox Biol. 2020 Jan;28:101321. doi: 10.1016/j.redox.2019.101321. Epub 2019 Sep 5.
346 Ramipril inhibits in vitro human mesangial cell proliferation and platelet-derived growth factor expression. Exp Nephrol. 1999 May-Jun;7(3):229-35. doi: 10.1159/000020606.
347 The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
348 Simvastatin inhibits PDGF-induced DNA synthesis in human glomerular mesangial cells. Kidney Int. 1993 Sep;44(3):503-8. doi: 10.1038/ki.1993.274.
349 Alcohol and Cannabinoids Differentially Affect HIV Infection and Function of Human Monocyte-Derived Dendritic Cells (MDDC). Front Microbiol. 2015 Dec 22;6:1452. doi: 10.3389/fmicb.2015.01452. eCollection 2015.
350 Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
351 Role of phenytoin in wound healing: microarray analysis of early transcriptional responses in human dermal fibroblasts. Biochem Biophys Res Commun. 2004 Feb 13;314(3):661-6. doi: 10.1016/j.bbrc.2003.12.146.
352 Progesterone regulation of implantation-related genes: new insights into the role of oestrogen. Cell Mol Life Sci. 2007 Apr;64(7-8):1009-32.
353 Differential expression of microRNAs and their predicted targets in renal cells exposed to amphotericin B and its complex with copper (II) ions. Toxicol Mech Methods. 2017 Sep;27(7):537-543. doi: 10.1080/15376516.2017.1333554. Epub 2017 Jun 8.
354 Regulatory role of nitric oxide on monocyte-derived dendritic cell functions. J Interferon Cytokine Res. 2003 Aug;23(8):423-31. doi: 10.1089/107999003322277838.
355 Direct evidence for immunomodulatory properties of ribavirin on T-cell reactivity to hepatitis C virus. Antiviral Res. 2007 Jul;75(1):36-42. doi: 10.1016/j.antiviral.2006.11.008. Epub 2006 Dec 13.
356 Differential effects of three antibiotics on T helper cell cytokine expression. J Antimicrob Chemother. 2005 Sep;56(3):502-6. doi: 10.1093/jac/dki251. Epub 2005 Jul 8.
357 Simvastatin inhibits IL-17 secretion by targeting multiple IL-17-regulatory cytokines and by inhibiting the expression of IL-17 transcription factor RORC in CD4+ lymphocytes. J Immunol. 2008 May 15;180(10):6988-96. doi: 10.4049/jimmunol.180.10.6988.
358 The flavonoid, quercetin, differentially regulates Th-1 (IFNgamma) and Th-2 (IL4) cytokine gene expression by normal peripheral blood mononuclear cells. Biochim Biophys Acta. 2002 Dec 16;1593(1):29-36. doi: 10.1016/s0167-4889(02)00328-2.
359 [Effects of vitamin A on the differentiation, maturation and functions of dendritic cells from cord blood]. Zhonghua Er Ke Za Zhi. 2004 May;42(5):340-3.
360 Effect of zidovudine therapy in patients with HIV infection on endogenous interferon plasma levels and the hepatic cytochrome P450 enzyme system. Chemotherapy. 1998 May-Jun;44(3):174-80. doi: 10.1159/000007112.
361 Detection of Drug-Responsive T-Lymphocytes in a Case of Fatal Antituberculosis Drug-Related Liver Injury. Chem Res Toxicol. 2016 Nov 21;29(11):1793-1795. doi: 10.1021/acs.chemrestox.6b00393. Epub 2016 Nov 9.
362 ERE-independent ERalpha target genes differentially expressed in human breast tumors. Mol Cell Endocrinol. 2005 Dec 21;245(1-2):53-9. doi: 10.1016/j.mce.2005.10.003. Epub 2005 Nov 17.
363 Reactive metabolite of gefitinib activates inflammasomes: implications for gefitinib-induced idiosyncratic reaction. J Toxicol Sci. 2020;45(11):673-680. doi: 10.2131/jts.45.673.
364 Gypenosides protect retinal pigment epithelium cells from oxidative stress. Food Chem Toxicol. 2018 Feb;112:76-85.
365 (9)-Tetrahydrocannabinol Suppresses Monocyte-Mediated Astrocyte Production of Monocyte Chemoattractant Protein 1 and Interleukin-6 in a Toll-Like Receptor 7-Stimulated Human Coculture. J Pharmacol Exp Ther. 2019 Oct;371(1):191-201. doi: 10.1124/jpet.119.260661. Epub 2019 Aug 5.
366 Changes in gene expression profiles in response to selenium supplementation among individuals with arsenic-induced pre-malignant skin lesions. Toxicol Lett. 2007 Mar 8;169(2):162-76. doi: 10.1016/j.toxlet.2007.01.006. Epub 2007 Jan 19.
367 Profiling the immunotoxicity of chemicals based on in vitro evaluation by a combination of the Multi-ImmunoTox assay and the IL-8 Luc assay. Arch Toxicol. 2018 Jun;92(6):2043-2054. doi: 10.1007/s00204-018-2199-7. Epub 2018 Mar 29.
368 Spironolactone induces apoptosis in human mononuclear cells. Association between apoptosis and cytokine suppression. Apoptosis. 2006 Apr;11(4):573-9. doi: 10.1007/s10495-006-4919-3.
369 Activation of PPAR and inhibition of cell proliferation reduces key proteins associated with the basal subtype of bladder cancer in As3+-transformed UROtsa cells. PLoS One. 2020 Aug 21;15(8):e0237976. doi: 10.1371/journal.pone.0237976. eCollection 2020.
370 Proteomics-based identification of differentially abundant proteins from human keratinocytes exposed to arsenic trioxide. J Proteomics Bioinform. 2014 Jul;7(7):166-178.
371 Impact of extracellular folate levels on global gene expression. Mol Pharmacol. 2001 Dec;60(6):1288-95. doi: 10.1124/mol.60.6.1288.
372 Retinoic acid receptor- and retinoid X receptor-selective retinoids activate signaling pathways that converge on AP-1 and inhibit squamous differentiation in human bronchial epithelial cells. Cell Growth Differ. 1996 Aug;7(8):997-1004.
373 Methamphetamine alters the normal progression by inducing cell cycle arrest in astrocytes. PLoS One. 2014 Oct 7;9(10):e109603.
374 Exposure to Insecticides Modifies Gene Expression and DNA Methylation in Hematopoietic Tissues In Vitro. Int J Mol Sci. 2023 Mar 26;24(7):6259. doi: 10.3390/ijms24076259.
375 p53-R175H mutant gains new function in regulation of doxorubicin-induced apoptosis. Int J Cancer. 2005 Apr 10;114(3):331-6. doi: 10.1002/ijc.20818.
376 Azidothymidine and cisplatin increase p14ARF expression in OVCAR-3 ovarian cancer cell line. Toxicol Appl Pharmacol. 2006 Oct 1;216(1):89-97. doi: 10.1016/j.taap.2006.04.015. Epub 2006 May 19.
377 Quantitative analysis of gene expression changes in response to genotoxic compounds. Toxicol In Vitro. 2017 Mar;39:15-28. doi: 10.1016/j.tiv.2016.11.004. Epub 2016 Nov 5.
378 Induction of apoptosis by cidofovir in human papillomavirus (HPV)-positive cells. Oncol Res. 2000;12(9-10):397-408. doi: 10.3727/096504001108747855.
379 Gallic acid potentiates the apoptotic effect of paclitaxel and carboplatin via overexpression of Bax and P53 on the MCF-7 human breast cancer cell line. J Biochem Mol Toxicol. 2021 Feb;35(2):e22638. doi: 10.1002/jbt.22638. Epub 2020 Oct 1.
380 Regulation of human dUTPase gene expression and p53-mediated transcriptional repression in response to oxaliplatin-induced DNA damage. Nucleic Acids Res. 2009 Jan;37(1):78-95. doi: 10.1093/nar/gkn910. Epub 2008 Nov 16.
381 Nitrogen Mustard Alkylates and Cross-Links p53 in Human Keratinocytes. Chem Res Toxicol. 2022 Apr 18;35(4):636-650. doi: 10.1021/acs.chemrestox.1c00420. Epub 2022 Mar 21.
382 Fulvestrant induces resistance by modulating GPER and CDK6 expression: implication of methyltransferases, deacetylases and the hSWI/SNF chromatin remodelling complex. Br J Cancer. 2013 Nov 12;109(10):2751-62. doi: 10.1038/bjc.2013.583. Epub 2013 Oct 29.
383 Gingival Stromal Cells as an In Vitro Model: Cannabidiol Modulates Genes Linked With Amyotrophic Lateral Sclerosis. J Cell Biochem. 2017 Apr;118(4):819-828. doi: 10.1002/jcb.25757. Epub 2016 Nov 28.
384 MS4A3-HSP27 target pathway reveals potential for haematopoietic disorder treatment in alimentary toxic aleukia. Cell Biol Toxicol. 2023 Feb;39(1):201-216. doi: 10.1007/s10565-021-09639-4. Epub 2021 Sep 28.
385 Inflammation in methotrexate-induced pulmonary toxicity occurs via the p38 MAPK pathway. Toxicology. 2009 Feb 27;256(3):183-90. doi: 10.1016/j.tox.2008.11.016. Epub 2008 Nov 28.
386 Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
387 Motexafin gadolinium and zinc induce oxidative stress responses and apoptosis in B-cell lymphoma lines. Cancer Res. 2005 Dec 15;65(24):11676-88.
388 Role of NADPH oxidase in arsenic-induced reactive oxygen species formation and cytotoxicity in myeloid leukemia cells. Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4578-83.
389 Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
390 Cytochrome P450 1A1/2 induction by antiparasitic drugs: dose-dependent increase in ethoxyresorufin O-deethylase activity and mRNA caused by quinine, primaquine and albendazole in HepG2 cells. Eur J Clin Pharmacol. 2002 Nov;58(8):537-42.
391 Association of CYP1A1 and CYP1B1 inhibition in in vitro assays with drug-induced liver injury. J Toxicol Sci. 2021;46(4):167-176. doi: 10.2131/jts.46.167.
392 Anti-androgenic effect of 6-formylindolo[3,2-b]carbazole (FICZ) in LNCaP cells is mediated by the aryl hydrocarbon-androgen receptors cross-talk. Steroids. 2020 Jan;153:108508. doi: 10.1016/j.steroids.2019.108508. Epub 2019 Oct 3.
393 Pharmacologic profiling of human and rat cytochrome P450 1A1 and 1A2 induction and competition. Arch Toxicol. 2008 Dec;82(12):909-21.
394 Effect of CYP1A1 gene polymorphisms on estrogen metabolism and bone density. J Bone Miner Res. 2005 Feb;20(2):232-9. doi: 10.1359/JBMR.041110. Epub 2004 Nov 16.
395 Increased sensitivity for troglitazone-induced cytotoxicity using a human in vitro co-culture model. Toxicol In Vitro. 2009 Oct;23(7):1387-95.
396 Isoform-specific induction of a human aldo-keto reductase by polycyclic aromatic hydrocarbons (PAHs), electrophiles, and oxidative stress: implications for the alternative pathway of PAH activation catalyzed by human dihydrodiol dehydrogenase. Cancer Res. 1999 Feb 1;59(3):607-14.
397 Gene expression changes in human small airway epithelial cells exposed to Delta9-tetrahydrocannabinol. Toxicol Lett. 2005 Aug 14;158(2):95-107.
398 The metallohormone cadmium modulates AhR-associated gene expression in the small intestine of rats similar to ethinyl-estradiol. Arch Toxicol. 2013 Apr;87(4):633-43.
399 Evidence for a new human CYP1A1 regulation pathway involving PPAR-alpha and 2 PPRE sites. Gastroenterology. 2004 Nov;127(5):1436-45.
400 Dicloxacillin and erythromycin at high concentrations increase ICAM-1 expression by endothelial cells: a possible factor in the pathogenesis of infusion phlebitis. J Antimicrob Chemother. 2004 Feb;53(2):174-9. doi: 10.1093/jac/dkh056. Epub 2004 Jan 16.
401 Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1. FASEB J. 2012 Apr;26(4):1535-48. doi: 10.1096/fj.11-198184. Epub 2011 Dec 23.
402 The effect of fexofenadine on expression of intercellular adhesion molecule 1 and induction of apoptosis on peripheral eosinophils. Allergy Asthma Proc. 2005 Jul-Aug;26(4):292-8.
403 Antiallergic effects of H1-receptor antagonists. Allergy. 2000;55 Suppl 64:17-27. doi: 10.1034/j.1398-9995.2000.00803.x.
404 Cytokine mRNA profiles in cultured human skin component cells exposed to various chemicals: a simulation model of epicutaneous stimuli induced by skin barrier perturbation in comparison with that due to exposure to haptens or irritant. J Dermatol Sci. 2001 Jun;26(2):85-93. doi: 10.1016/s0923-1811(00)00165-1.
405 Correlation of sICAM-1 and sVCAM-1 level with biochemical, histological and viral findings in chronic hepatitis C after interferon-alpha + ribavirin therapy. Rom J Gastroenterol. 2003 Jun;12(2):91-5.
406 Some non-sensitizers upregulate CD54 expression by activation of the NLRP3 inflammasome in THP-1 cells. J Toxicol Sci. 2019;44(3):213-224. doi: 10.2131/jts.44.213.
407 Dimethyl Fumarate Inhibits the Nuclear Factor B Pathway in Breast Cancer Cells by Covalent Modification of p65 Protein. J Biol Chem. 2016 Feb 12;291(7):3639-47. doi: 10.1074/jbc.M115.679704. Epub 2015 Dec 18.
408 Structure based drug design of crizotinib (PF-02341066), a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK). J Med Chem. 2011 Sep 22;54(18):6342-63. doi: 10.1021/jm2007613. Epub 2011 Aug 18.
409 Expression profile analysis of human peripheral blood mononuclear cells in response to aspirin. Arch Immunol Ther Exp (Warsz). 2005 Mar-Apr;53(2):151-8.
410 LSD1 activates a lethal prostate cancer gene network independently of its demethylase function. Proc Natl Acad Sci U S A. 2018 May 1;115(18):E4179-E4188.
411 Sorafenib induces cell death in chronic lymphocytic leukemia by translational downregulation of Mcl-1. Leukemia. 2011 May;25(5):838-47. doi: 10.1038/leu.2011.2. Epub 2011 Feb 4.
412 Molecular mechanism of action of bisphenol and bisphenol A mediated by oestrogen receptor alpha in growth and apoptosis of breast cancer cells. Br J Pharmacol. 2013 May;169(1):167-78.
413 mTOR inhibition reverses acquired endocrine therapy resistance of breast cancer cells at the cell proliferation and gene-expression levels. Cancer Sci. 2008 Oct;99(10):1992-2003. doi: 10.1111/j.1349-7006.2008.00955.x.
414 Bexarotene activates the p53/p73 pathway in human cutaneous T-cell lymphoma. Br J Dermatol. 2009 Mar;160(3):519-26. doi: 10.1111/j.1365-2133.2008.08931.x. Epub 2008 Nov 25.
415 Differential gene expression of sulindac-treated human breast epithelial cells. Int J Oncol. 2005 Dec;27(6):1727-36.
416 Beta-carotene and apocarotenals promote retinoid signaling in BEAS-2B human bronchioepithelial cells. Arch Biochem Biophys. 2006 Nov 1;455(1):48-60.
417 Proton pump inhibitors interfere with the anti-tumor potency of RC48ADC. Toxicol In Vitro. 2022 Mar;79:105292. doi: 10.1016/j.tiv.2021.105292. Epub 2021 Dec 3.
418 Pyrimethamine induces apoptosis of melanoma cells via a caspase and cathepsin double-edged mechanism. Cancer Res. 2008 Jul 1;68(13):5291-300. doi: 10.1158/0008-5472.CAN-08-0222.
419 Synergistic effects of arsenic trioxide and silibinin on apoptosis and invasion in human glioblastoma U87MG cell line. Neurochem Res. 2012 Feb;37(2):370-80. doi: 10.1007/s11064-011-0620-1. Epub 2011 Oct 4.
420 Thyroid organotypic rat and human cultures used to investigate drug effects on thyroid function, hormone synthesis and release pathways. Toxicol Appl Pharmacol. 2012 Apr 1;260(1):81-8. doi: 10.1016/j.taap.2012.01.029. Epub 2012 Feb 8.
421 Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization. Autophagy. 2016 Nov;12(11):2213-2229. doi: 10.1080/15548627.2016.1213927. Epub 2016 Sep 16.
422 Discovery of molecular mechanisms of neuroprotection using cell-based bioassays and oligonucleotide arrays. Physiol Genomics. 2002 Oct 29;11(2):45-52. doi: 10.1152/physiolgenomics.00064.2002.
423 Moving toward integrating gene expression profiling into high-throughput testing: a gene expression biomarker accurately predicts estrogen receptor alpha modulation in a microarray compendium. Toxicol Sci. 2016 May;151(1):88-103.
424 Hypotensive shock and angio-oedema from angiotensin II receptor blocker: a class effect in spite of tripled tryptase values. J Intern Med. 2005 Oct;258(4):385-7. doi: 10.1111/j.1365-2796.2005.01547.x.
425 Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol. 2005 Nov;19(11):2685-95.
426 A Gene Expression Biomarker Identifies Chemical Modulators of Estrogen Receptor in an MCF-7 Microarray Compendium. Chem Res Toxicol. 2021 Feb 15;34(2):313-329. doi: 10.1021/acs.chemrestox.0c00243. Epub 2021 Jan 6.
427 Growth inhibition of ovarian tumor-initiating cells by niclosamide. Mol Cancer Ther. 2012 Aug;11(8):1703-12.
428 Gene expression profile induced by BCNU in human glioma cell lines with differential MGMT expression. J Neurooncol. 2005 Jul;73(3):189-98.
429 Resveratrol decreases breast cancer cell viability and glucose metabolism by inhibiting 6-phosphofructo-1-kinase. Biochimie. 2013 Jun;95(6):1336-43. doi: 10.1016/j.biochi.2013.02.013. Epub 2013 Feb 27.
430 Synthetic oleanane triterpenoid derivative CDDO-Me disrupts cellular bioenergetics to suppress pancreatic ductal adenocarcinoma via targeting SLC1A5. J Biochem Mol Toxicol. 2022 Nov;36(11):e23192. doi: 10.1002/jbt.23192. Epub 2022 Aug 5.
431 Inhibiting ubiquitination causes an accumulation of SUMOylated newly synthesized nuclear proteins at PML bodies. J Biol Chem. 2019 Oct 18;294(42):15218-15234. doi: 10.1074/jbc.RA119.009147. Epub 2019 Jul 8.
432 Mitochondrial Uncoupling Induces Epigenome Remodeling and Promotes Differentiation in Neuroblastoma. Cancer Res. 2023 Jan 18;83(2):181-194. doi: 10.1158/0008-5472.CAN-22-1029.
433 Dasatinib reverses cancer-associated fibroblasts (CAFs) from primary lung carcinomas to a phenotype comparable to that of normal fibroblasts. Mol Cancer. 2010 Jun 27;9:168.
434 Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
435 Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
436 Evidence of securin-mediated resistance to gefitinib-induced apoptosis in human cancer cells. Chem Biol Interact. 2013 Apr 25;203(2):412-22. doi: 10.1016/j.cbi.2013.03.011. Epub 2013 Mar 22.
437 Cigarette smoke and asbestos activate poly-ADP-ribose polymerase in alveolar epithelial cells. J Investig Med. 2001 Jan;49(1):68-76. doi: 10.2310/6650.2001.34092.
438 Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53. Cancer Res. 2004 May 1;64(9):3022-9. doi: 10.1158/0008-5472.can-03-1880.
439 The antidepressants imipramine, clomipramine, and citalopram induce apoptosis in human acute myeloid leukemia HL-60 cells via caspase-3 activation. J Biochem Mol Toxicol. 1999;13(6):338-47. doi: 10.1002/(sici)1099-0461(1999)13:6<338::aid-jbt8>3.0.co;2-7.
440 Ciprofloxacin mediated cell growth inhibition, S/G2-M cell cycle arrest, and apoptosis in a human transitional cell carcinoma of the bladder cell line. Clin Cancer Res. 2000 Mar;6(3):891-900.
441 Investigation of molecular mechanisms underlying the antiproliferative effects of colchicine against PC3 prostate cancer cells. Toxicol In Vitro. 2021 Jun;73:105138. doi: 10.1016/j.tiv.2021.105138. Epub 2021 Mar 6.
442 Sulindac enhances adenoviral vector expressing mda-7/IL-24-mediated apoptosis in human lung cancer. Mol Cancer Ther. 2005 Feb;4(2):291-304.
443 Methotrexate induces poly(ADP-ribose) polymerase-dependent, caspase 3-independent apoptosis in subsets of proliferating CD4+ T cells. Clin Exp Immunol. 2007 May;148(2):288-95. doi: 10.1111/j.1365-2249.2007.03335.x. Epub 2007 Feb 7.
444 Monomeric and oligomeric flavanols maintain the endogenous glucocorticoid response in human macrophages in pro-oxidant conditions in vitro. Chem Biol Interact. 2018 Aug 1;291:237-244.
445 Nicotine up-regulates IL-8 expression in human gingival epithelial cells following stimulation with IL-1 or P. gingivalis lipopolysaccharide via nicotinic acetylcholine receptor signalling. Arch Oral Biol. 2012 May;57(5):483-90. doi: 10.1016/j.archoralbio.2011.10.007. Epub 2011 Nov 25.
446 Ca(2+) Signaling and IL-8 Secretion in Human Testicular Peritubular Cells Involve the Cation Channel TRPV2. Int J Mol Sci. 2018 Sep 19;19(9):2829. doi: 10.3390/ijms19092829.
447 Calcium pantothenate modulates gene expression in proliferating human dermal fibroblasts. Exp Dermatol. 2009 Nov;18(11):969-78. doi: 10.1111/j.1600-0625.2009.00884.x. Epub 2009 Apr 8.
448 Nitrogen mustard prevents transport of Fra-1 into the nucleus to promote c-Fos- and FosB-dependent IL-8 induction in injured mouse epidermis. Toxicol Lett. 2020 Feb 1;319:256-263. doi: 10.1016/j.toxlet.2019.10.006. Epub 2019 Oct 19.
449 Nitric oxide synthase inhibitors attenuate ozone-induced airway inflammation in guinea pigs. Possible role of interleukin-8. Am J Respir Crit Care Med. 2000 Jan;161(1):249-56. doi: 10.1164/ajrccm.161.1.9804096.
450 4.8% sevoflurane induces activation of autophagy in human neuroblastoma SH-SY5Y cells by the AMPK/mTOR signaling pathway. Neurotoxicology. 2022 May;90:256-264. doi: 10.1016/j.neuro.2022.04.008. Epub 2022 Apr 23.
451 Enhanced chemotherapeutic efficacy of docetaxel in human lung cancer cell line via GLUT1 inhibitor. J Biochem Mol Toxicol. 2023 Jun;37(6):e23348. doi: 10.1002/jbt.23348. Epub 2023 Mar 31.
452 Breast cancer cells response to the antineoplastic agents cisplatin, carboplatin, and doxorubicin at the mRNA expression levels of distinct apoptosis-related genes, including the new member, BCL2L12. Ann N Y Acad Sci. 2007 Jan;1095:35-44. doi: 10.1196/annals.1397.005.
453 Extracellular signal-regulated kinase activation and Bcl-2 downregulation mediate apoptosis after gemcitabine treatment partly via a p53-independent pathway. Eur J Pharmacol. 2004 Oct 19;502(3):169-83. doi: 10.1016/j.ejphar.2004.09.006.
454 Verapamil potentiates anti-glioblastoma efficacy of temozolomide by modulating apoptotic signaling. Toxicol In Vitro. 2018 Oct;52:306-313. doi: 10.1016/j.tiv.2018.07.001. Epub 2018 Jul 9.
455 Inhibition of caspase-dependent mitochondrial permeability transition protects airway epithelial cells against mustard-induced apoptosis. Apoptosis. 2006 Sep;11(9):1545-59. doi: 10.1007/s10495-006-8764-1.
456 Sertraline, an antidepressant, induces apoptosis in hepatic cells through the mitogen-activated protein kinase pathway. Toxicol Sci. 2014 Feb;137(2):404-15. doi: 10.1093/toxsci/kft254. Epub 2013 Nov 5.
457 Multifaceted preventive effects of single agent quercetin on a human prostate adenocarcinoma cell line (PC-3): implications for nutritional transcriptomics and multi-target therapy. Med Oncol. 2011 Dec;28(4):1395-404. doi: 10.1007/s12032-010-9603-3. Epub 2010 Jul 2.
458 Insulin regulation of hexose transport in mouse 3T3-L1 cells expressing the human HepG2 glucose transporter. J Biol Chem. 1990 Nov 25;265(33):20106-16.
459 Effects of troglitazone on cellular differentiation, insulin signaling, and glucose metabolism in cultured human skeletal muscle cells. Biochem Biophys Res Commun. 2001 Jan 26;280(3):664-74. doi: 10.1006/bbrc.2000.4216.
460 Disturbance of cellular glucose transport by two prevalently used fluoroquinolone antibiotics ciprofloxacin and levofloxacin involves glucose transporter type 1. Toxicol Lett. 2009 Jan 30;184(2):81-4. doi: 10.1016/j.toxlet.2008.10.017. Epub 2008 Oct 28.
461 Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses. PLoS One. 2010 Dec 17;5(12):e14352. doi: 10.1371/journal.pone.0014352.
462 AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance. Cancer Cell. 2009 Nov 6;16(5):401-12. doi: 10.1016/j.ccr.2009.09.028.
463 Combined BCR-ABL inhibition with lentiviral-delivered shRNA and dasatinib augments induction of apoptosis in Philadelphia-positive cells. Exp Hematol. 2009 Feb;37(2):206-14. doi: 10.1016/j.exphem.2008.10.013. Epub 2008 Dec 18.
464 The proapoptotic effect of zoledronic acid is independent of either the bone microenvironment or the intrinsic resistance to bortezomib of myeloma cells and is enhanced by the combination with arsenic trioxide. Exp Hematol. 2011 Jan;39(1):55-65.
465 Clinical determinants of response to irinotecan-based therapy derived from cell line models. Clin Cancer Res. 2008 Oct 15;14(20):6647-55.
466 Arsenic trioxide induces autophagic cell death in osteosarcoma cells via the ROS-TFEB signaling pathway. Biochem Biophys Res Commun. 2018 Jan 29;496(1):167-175. doi: 10.1016/j.bbrc.2018.01.018. Epub 2018 Jan 4.
467 Induction of Sestrin2 by pterostilbene suppresses ethanol-triggered hepatocyte senescence by degrading CCN1 via p62-dependent selective autophagy. Cell Biol Toxicol. 2023 Jun;39(3):729-749. doi: 10.1007/s10565-021-09635-8. Epub 2021 Aug 17.
468 Rosiglitazone induces autophagy in H295R and cell cycle deregulation in SW13 adrenocortical cancer cells. Exp Cell Res. 2011 Jun 10;317(10):1397-410. doi: 10.1016/j.yexcr.2011.02.014. Epub 2011 Mar 3.
469 Effects of formaldehyde, acetaldehyde, benzoyl peroxide, and hydrogen peroxide on cultured normal human bronchial epithelial cells. Cancer Res. 1985 Jun;45(6):2522-6.
470 Methotrexate induced differentiation in colon cancer cells is primarily due to purine deprivation. J Cell Biochem. 2006 Sep 1;99(1):146-55. doi: 10.1002/jcb.20908.
471 Quercetin inhibits the expression and function of the androgen receptor in LNCaP prostate cancer cells. Carcinogenesis. 2001 Mar;22(3):409-14. doi: 10.1093/carcin/22.3.409.
472 Adrenergic modulation of cardiac development in the rat: effects of prenatal exposure to propranolol via continuous maternal infusion. J Dev Physiol. 1990 May;13(5):243-9.
473 Cyclosporine A--induced oxidative stress in human renal mesangial cells: a role for ERK 1/2 MAPK signaling. Toxicol Sci. 2012 Mar;126(1):101-13.
474 Identification of vitamin D3 target genes in human breast cancer tissue. J Steroid Biochem Mol Biol. 2016 Nov;164:90-97.
475 Evaluation of a human iPSC-derived BBB model for repeated dose toxicity testing with cyclosporine A as model compound. Toxicol In Vitro. 2021 Jun;73:105112. doi: 10.1016/j.tiv.2021.105112. Epub 2021 Feb 22.
476 The genomic response of Ishikawa cells to bisphenol A exposure is dose- and time-dependent. Toxicology. 2010 Apr 11;270(2-3):137-49. doi: 10.1016/j.tox.2010.02.008. Epub 2010 Feb 17.
477 Inhibition of interleukin-1-induced endothelial tissue factor expression by the synthetic cannabinoid WIN 55,212-2. Oncotarget. 2016 Sep 20;7(38):61438-61457. doi: 10.18632/oncotarget.11367.
478 Elucidating mechanisms of toxicity using phenotypic data from primary human cell systems--a chemical biology approach for thrombosis-related side effects. Int J Mol Sci. 2015 Jan 5;16(1):1008-29. doi: 10.3390/ijms16011008.
479 The effects of chemotherapeutic agents on the regulation of thrombin on cell surfaces. Br J Haematol. 2003 Jan;120(2):315-24. doi: 10.1046/j.1365-2141.2003.03971.x.
480 Mechanisms of tissue factor induction by the uremic toxin indole-3 acetic acid through aryl hydrocarbon receptor/nuclear factor-kappa B signaling pathway in human endothelial cells. Arch Toxicol. 2019 Jan;93(1):121-136.
481 Simvastatin attenuates vascular hypercoagulability in cardiac transplant recipients. Transplantation. 2000 May 15;69(9):1830-6. doi: 10.1097/00007890-200005150-00017.
482 Resveratrol and quercetin down-regulate tissue factor expression by human stimulated vascular cells. J Thromb Haemost. 2003 May;1(5):1089-95. doi: 10.1046/j.1538-7836.2003.00217.x.
483 Non-nutritional sweeteners effects on endothelial vascular function. Toxicol In Vitro. 2020 Feb;62:104694. doi: 10.1016/j.tiv.2019.104694. Epub 2019 Oct 23.
484 Tissue factors on acute promyelocytic leukemia and endothelial cells are differently regulated by retinoic acid, arsenic trioxide and chemotherapeutic agents. Leukemia. 1999 Jul;13(7):1062-70. doi: 10.1038/sj.leu.2401448.
485 Cannabinoids synergize with carfilzomib, reducing multiple myeloma cells viability and migration. Oncotarget. 2016 Nov 22;7(47):77543-77557. doi: 10.18632/oncotarget.12721.
486 Hsa-let-7g miRNA regulates the anti-tumor effects of gastric cancer cells under oxidative stress through the expression of DDR genes. J Toxicol Sci. 2015 Jun;40(3):329-38. doi: 10.2131/jts.40.329.
487 Inhibition of cardiomyocyte differentiation of human induced pluripotent stem cells by Ribavirin: Implication for its cardiac developmental toxicity. Toxicology. 2020 Apr 15;435:152422. doi: 10.1016/j.tox.2020.152422. Epub 2020 Feb 26.
488 Synthesis and structure-activity relationships of new antiproliferative and proapoptotic retinoid-related biphenyl-4-yl-acrylic acids. Bioorg Med Chem. 2007 Jul 15;15(14):4863-75. doi: 10.1016/j.bmc.2007.04.057. Epub 2007 May 3.
489 Methotrexate induces apoptosis through p53/p21-dependent pathway and increases E-cadherin expression through downregulation of HDAC/EZH2. Biochem Pharmacol. 2011 Feb 15;81(4):510-7. doi: 10.1016/j.bcp.2010.11.014. Epub 2010 Nov 27.
490 Actinomycin D inhibits the expression of the cystine/glutamate transporter xCT via attenuation of CD133 synthesis in CD133(+) HCC. Chem Biol Interact. 2019 Aug 25;309:108713. doi: 10.1016/j.cbi.2019.06.026. Epub 2019 Jun 19.
491 Simvastatin and purine analogs have a synergic effect on apoptosis of chronic lymphocytic leukemia cells. Ann Hematol. 2010 Nov;89(11):1115-24. doi: 10.1007/s00277-010-0988-z. Epub 2010 May 25.
492 The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib. Toxicol Sci. 2023 Dec 21;197(1):69-78. doi: 10.1093/toxsci/kfad099.
493 The isoflavonoids genistein and quercetin activate different stress signaling pathways as shown by analysis of site-specific phosphorylation of ATM, p53 and histone H2AX. DNA Repair (Amst). 2004 Mar 4;3(3):235-44. doi: 10.1016/j.dnarep.2003.10.014.
494 A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
495 Hedgehog signaling antagonist GDC-0449 (Vismodegib) inhibits pancreatic cancer stem cell characteristics: molecular mechanisms. PLoS One. 2011;6(11):e27306. doi: 10.1371/journal.pone.0027306. Epub 2011 Nov 8.
496 The long-term impact of folic acid in pregnancy on offspring DNA methylation: follow-up of the Aberdeen Folic Acid Supplementation Trial (AFAST). Int J Epidemiol. 2018 Jun 1;47(3):928-937. doi: 10.1093/ije/dyy032.
497 Interleukin-19 as a translational indicator of renal injury. Arch Toxicol. 2015 Jan;89(1):101-6.
498 Dasatinib inhibits the growth and survival of neoplastic human eosinophils (EOL-1) through targeting of FIP1L1-PDGFRalpha. Exp Hematol. 2008 Oct;36(10):1244-53. doi: 10.1016/j.exphem.2008.04.017. Epub 2008 Jul 10.
499 Response rate of fibrosarcoma cells to cytotoxic drugs on the expression level correlates to the therapeutic response rate of fibrosarcomas and is mediated by regulation of apoptotic pathways. BMC Cancer. 2005 Jul 7;5:74. doi: 10.1186/1471-2407-5-74.
500 Ursodeoxycholic acid suppresses Cox-2 expression in colon cancer: roles of Ras, p38, and CCAAT/enhancer-binding protein. Nutr Cancer. 2008;60(3):389-400.
501 Quercetin represses apolipoprotein B expression by inhibiting the transcriptional activity of C/EBP. PLoS One. 2015 Apr 15;10(4):e0121784. doi: 10.1371/journal.pone.0121784. eCollection 2015.
502 Transcriptome-based functional classifiers for direct immunotoxicity. Arch Toxicol. 2014 Mar;88(3):673-89.
503 Inhibitory effect of quercetin on tryptase and MCP-1 chemokine release, and histidine decarboxylase mRNA transcription by human mast cell-1 cell line. Neuroimmunomodulation. 2006;13(3):179-86. doi: 10.1159/000098131. Epub 2006 Dec 21.
504 Troglitazone suppresses cell growth of KU812 cells independently of PPARgamma. Eur J Pharmacol. 2002 Feb 1;436(1-2):7-13. doi: 10.1016/s0014-2999(01)01577-1.
505 Systems analysis of transcriptome and proteome in retinoic acid/arsenic trioxide-induced cell differentiation/apoptosis of promyelocytic leukemia. Proc Natl Acad Sci U S A. 2005 May 24;102(21):7653-8.
506 The CML-related oncoprotein BCR/ABL induces expression of histidine decarboxylase (HDC) and the synthesis of histamine in leukemic cells. Blood. 2006 Nov 15;108(10):3538-47. doi: 10.1182/blood-2005-12-028456. Epub 2006 Jul 18.
507 Decarboxylases as hypothetical targets for actions of organophosphates: Molecular modeling for prediction of hidden and unexpected health threats. Food Chem Toxicol. 2022 Mar;161:112856. doi: 10.1016/j.fct.2022.112856. Epub 2022 Feb 11.
508 Modulation of histidine decarboxylase activity and cytokine synthesis in human leukemic cell lines: relationship with basophilic and/or megakaryocytic differentiation. Exp Hematol. 1999 Aug;27(8):1295-305. doi: 10.1016/s0301-472x(99)00070-3.
509 Rescue of Pink1 Deficiency by Stress-Dependent Activation of Autophagy. Cell Chem Biol. 2017 Apr 20;24(4):471-480.e4. doi: 10.1016/j.chembiol.2017.03.005. Epub 2017 Mar 30.
510 A role for the autophagy regulator Transcription Factor EB in amiodarone-induced phospholipidosis. Biochem Pharmacol. 2015 Jun 1;95(3):201-9. doi: 10.1016/j.bcp.2015.03.017. Epub 2015 Apr 13.
511 Transcriptome and DNA methylome dynamics during triclosan-induced cardiomyocyte differentiation toxicity. Stem Cells Int. 2018 Oct 29;2018:8608327.
512 Thalidomide and Its Analogs Differentially Target Fibroblast Growth Factor Receptors: Thalidomide Suppresses FGFR Gene Expression while Pomalidomide Dampens FGFR2 Activity. Chem Res Toxicol. 2019 Apr 15;32(4):589-602. doi: 10.1021/acs.chemrestox.8b00286. Epub 2019 Mar 15.
513 Unique signatures of stress-induced senescent human astrocytes. Exp Neurol. 2020 Dec;334:113466. doi: 10.1016/j.expneurol.2020.113466. Epub 2020 Sep 17.
514 Curcumin reduces the expression of survivin, leading to enhancement of arsenic trioxide-induced apoptosis in myelodysplastic syndrome and leukemia stem-like cells. Oncol Rep. 2016 Sep;36(3):1233-42. doi: 10.3892/or.2016.4944. Epub 2016 Jul 15.
515 Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
516 Quercetin protected against isoniazide-induced HepG2 cell apoptosis by activating the SIRT1/ERK pathway. J Biochem Mol Toxicol. 2019 Sep;33(9):e22369. doi: 10.1002/jbt.22369. Epub 2019 Jul 23.
517 Drug-induced liver injury: Oltipraz and C2-ceramide intervene HNF-1/GSTA1 expression via JNK signaling pathway. J Appl Toxicol. 2021 Dec;41(12):2011-2020. doi: 10.1002/jat.4181. Epub 2021 May 6.
518 A Study of Gentianae Radix et Rhizoma Class Differences Based on Chemical Composition and Core Efficacy. Molecules. 2023 Oct 17;28(20):7132. doi: 10.3390/molecules28207132.
519 Integrated assessment by multiple gene expression analysis of quercetin bioactivity on anticancer-related mechanisms in colon cancer cells in vitro. Eur J Nutr. 2005 Mar;44(3):143-56. doi: 10.1007/s00394-004-0503-1. Epub 2004 Apr 30.
520 Chronic occupational exposure to arsenic induces carcinogenic gene signaling networks and neoplastic transformation in human lung epithelial cells. Toxicol Appl Pharmacol. 2012 Jun 1;261(2):204-16.
521 Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
522 Estrogen receptor regulates E2F1 expression to mediate tamoxifen resistance. Mol Cancer Res. 2010 Mar;8(3):343-52. doi: 10.1158/1541-7786.MCR-09-0395. Epub 2010 Mar 9.
523 Down-regulation and decreased activity of cyclin-dependent kinase 2 in H2O2-induced premature senescence. Int J Biochem Cell Biol. 2003 Feb;35(2):246-54. doi: 10.1016/s1357-2725(02)00129-2.
524 Nonsteroidal anti-inflammatory drugs inhibit growth of human neuroendocrine tumor cells via G1 cell-cycle arrest. Int J Cancer. 2003 Dec 10;107(5):844-53. doi: 10.1002/ijc.11446.
525 Peripheral blood expression of nuclear factor-kappab-regulated genes is associated with rheumatoid arthritis disease activity and responds differentially to anti-tumor necrosis factor-alpha versus methotrexate. J Rheumatol. 2007 Sep;34(9):1817-22. Epub 2007 Aug 1.
526 Neurokinin-1 receptor (NK1R) inhibition sensitizes APL cells to anti-tumor effect of arsenic trioxide via restriction of NF-B axis: Shedding new light on resistance to Aprepitant. Int J Biochem Cell Biol. 2018 Oct;103:105-114. doi: 10.1016/j.biocel.2018.08.010. Epub 2018 Aug 23.
527 Microtubules are required for NF-kappaB nuclear translocation in neuroblastoma IMR-32 cells: modulation by zinc. J Neurochem. 2006 Oct;99(2):402-15. doi: 10.1111/j.1471-4159.2006.04005.x.
528 Protein phosphatase 2A interacts with and directly dephosphorylates RelA. J Biol Chem. 2001 Dec 21;276(51):47828-33. doi: 10.1074/jbc.M106103200. Epub 2001 Oct 8.
529 Activation of nuclear factor-kappa B pathway by simvastatin and RhoA silencing increases doxorubicin cytotoxicity in human colon cancer HT29 cells. Mol Pharmacol. 2008 Aug;74(2):476-84.
530 Prevention of deoxycholate-induced gastric apoptosis by aspirin: roles of NF-kappaB and PKC signaling. J Surg Res. 2008 Mar;145(1):66-73. doi: 10.1016/j.jss.2007.04.039. Epub 2007 Jul 20.
531 Treatment with anticancer agents induces dysregulation of specific Wnt signaling pathways in human ovarian luteinized granulosa cells in vitro. Toxicol Sci. 2013 Nov;136(1):183-92. doi: 10.1093/toxsci/kft175. Epub 2013 Aug 16.
532 Progesterone increases csk homologous kinase in HMC-1560 human mast cells and reduces cell proliferation. J Cell Biochem. 2007 Dec 1;102(5):1271-80. doi: 10.1002/jcb.21357.
533 Cannabidiol upregulates melanogenesis through CB1 dependent pathway by activating p38 MAPK and p42/44 MAPK. Chem Biol Interact. 2017 Aug 1;273:107-114. doi: 10.1016/j.cbi.2017.06.005. Epub 2017 Jun 7.
534 Growth stimulation of human pulmonary adenocarcinoma cells and small airway epithelial cells by beta-carotene via activation of cAMP, PKA, CREB and ERK1/2. Int J Cancer. 2006 Mar 15;118(6):1370-80. doi: 10.1002/ijc.21537.
535 Estrogen and pure antiestrogen fulvestrant (ICI 182 780) augment cell-matrigel adhesion of MCF-7 breast cancer cells through a novel G protein coupled estrogen receptor (GPR30)-to-calpain signaling axis. Toxicol Appl Pharmacol. 2014 Mar 1;275(2):176-81. doi: 10.1016/j.taap.2014.01.005. Epub 2014 Jan 17.
536 Inhibition of activator protein 1 by barbiturates is mediated by differential effects on mitogen-activated protein kinases and the small G proteins ras and rac-1. J Pharmacol Exp Ther. 2004 Dec;311(3):1232-40. doi: 10.1124/jpet.104.071332. Epub 2004 Jul 19.
537 Growth of hormone-dependent MCF-7 breast cancer cells is promoted by constitutive caveolin-1 whose expression is lost in an EGF-R-mediated manner during development of tamoxifen resistance. Breast Cancer Res Treat. 2010 Feb;119(3):575-91. doi: 10.1007/s10549-009-0355-8. Epub 2009 Mar 15.
538 Effect of histamine H1 receptor antagonists on TARC/CCL17 and MDC/CCL22 production from CD14+ cells induced by antigenic stimulation in vitro. Int Arch Allergy Immunol. 2011;155(1):38-51. doi: 10.1159/000318720. Epub 2010 Nov 25.
539 SIRT3 Mediates the Antioxidant Effect of Hydrogen Sulfide in Endothelial Cells. Antioxid Redox Signal. 2016 Feb 20;24(6):329-43. doi: 10.1089/ars.2015.6331. Epub 2015 Nov 10.
540 Downregulation of mitogen-activated protein kinases (MAPKs) in chronic ethanol-induced fatty liver. Toxicol Mech Methods. 2020 Jul;30(6):407-416. doi: 10.1080/15376516.2020.1747126. Epub 2020 Apr 1.
541 A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling. Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16657-62. doi: 10.1073/pnas.0707936104. Epub 2007 Oct 9.
542 The stent-eluting drugs sirolimus and paclitaxel suppress healing of the endothelium by induction of autophagy. Am J Pathol. 2009 Nov;175(5):2226-34.
543 Modulation of apoptosis in HaCaT keratinocytes via differential regulation of ERK signaling pathway by flavonoids. J Biol Chem. 2005 Sep 9;280(36):31498-507. doi: 10.1074/jbc.M505537200. Epub 2005 Jul 13.
544 Cannabidiol Protects Human Skin Keratinocytes from Hydrogen-Peroxide-Induced Oxidative Stress via Modulation of the Caspase-1-IL-1 Axis. J Nat Prod. 2021 May 28;84(5):1563-1572. doi: 10.1021/acs.jnatprod.1c00083. Epub 2021 May 6.
545 Improved apoptotic cell death in drug-resistant non-small-cell lung cancer cells by tumor necrosis factor-related apoptosis-inducing ligand-based treatment. J Pharmacol Exp Ther. 2014 Mar;348(3):360-71. doi: 10.1124/jpet.113.210054. Epub 2013 Dec 17.
546 Hydroquinone triggers pyroptosis and endoplasmic reticulum stress via AhR-regulated oxidative stress in human lymphocytes. Toxicol Lett. 2023 Mar 1;376:39-50. doi: 10.1016/j.toxlet.2023.01.005. Epub 2023 Jan 13.
547 Inhibition of autophagic flux differently modulates cannabidiol-induced death in 2D and 3D glioblastoma cell cultures. Sci Rep. 2020 Feb 14;10(1):2687. doi: 10.1038/s41598-020-59468-4.
548 Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells. Free Radic Biol Med. 2002 Nov 15;33(10):1419-32.
549 Sulindac suppresses beta-catenin expression in human cancer cells. Eur J Pharmacol. 2008 Mar 31;583(1):26-31. doi: 10.1016/j.ejphar.2007.12.034. Epub 2008 Feb 5.
550 Multifaceted suppression of aggressive behavior of thyroid carcinoma by all-trans retinoic acid induced re-differentiation. Mol Cell Endocrinol. 2012 Jan 2;348(1):260-9. doi: 10.1016/j.mce.2011.09.002. Epub 2011 Sep 6.
551 Arsenic trioxide and 2-methoxyestradiol reduce beta-catenin accumulation after proteasome inhibition and enhance the sensitivity of myeloma cells to Bortezomib. Leuk Res. 2008 Nov;32(11):1674-83. doi: 10.1016/j.leukres.2008.03.039. Epub 2008 May 15.
552 Effect of aspirin on the Wnt/beta-catenin pathway is mediated via protein phosphatase 2A. Oncogene. 2006 Oct 19;25(49):6447-56. doi: 10.1038/sj.onc.1209658. Epub 2006 Jul 31.
553 Benzene metabolite hydroquinone induces apoptosis of bone marrow mononuclear cells through inhibition of -catenin signaling. Toxicol In Vitro. 2018 Feb;46:361-369. doi: 10.1016/j.tiv.2017.08.018. Epub 2017 Sep 5.
554 Anti-androgen 2-hydroxyflutamide modulates cadherin, catenin and androgen receptor phosphorylation in androgen-sensitive LNCaP and androgen-independent PC3 prostate cancer cell lines acting via PI3K/Akt and MAPK/ERK1/2 pathways. Toxicol In Vitro. 2017 Apr;40:324-335. doi: 10.1016/j.tiv.2017.01.019. Epub 2017 Feb 2.
555 Chemoprevention of chemically-induced mammary and colon carcinogenesis by 1alpha-hydroxyvitamin D5. J Steroid Biochem Mol Biol. 2005 Oct;97(1-2):129-36. doi: 10.1016/j.jsbmb.2005.06.008. Epub 2005 Jul 26.
556 Different apoptosis ratios and gene expressions in two human cell lines after sevoflurane anaesthesia. Acta Anaesthesiol Scand. 2009 Oct;53(9):1192-9. doi: 10.1111/j.1399-6576.2009.02036.x. Epub 2009 Jun 30.
557 [Mechanisms underlying the effect of arsenic trioxide on proliferation inhibition and apoptosis induction in myeloma cell line u266]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2007 Oct;15(5):982-5.
558 Lovastatin lactone elicits human lung cancer cell apoptosis via a COX-2/PPAR-dependent pathway. Oncotarget. 2016 Mar 1;7(9):10345-62. doi: 10.18632/oncotarget.7213.
559 Comparison of burst of reactive oxygen species and activation of caspase-3 in apoptosis of K562 and HL-60 cells induced by docetaxel. Cancer Lett. 2004 Oct 8;214(1):103-13. doi: 10.1016/j.canlet.2004.03.047.
560 Induction of mitochondrial manganese superoxide dismutase confers resistance to apoptosis in acute myeloblastic leukaemia cells exposed to etoposide. Br J Haematol. 2000 Mar;108(3):574-81. doi: 10.1046/j.1365-2141.2000.01852.x.
561 Cisplatin-enhanced sensitivity of glioblastoma multiforme U251 cells to adenovirus-delivered TRAIL in vitro. Tumour Biol. 2010 Dec;31(6):613-22. doi: 10.1007/s13277-010-0077-x. Epub 2010 Jul 11.
562 Insulin-like growth factor I is the key growth factor in serum that protects neuroblastoma cells from hyperosmotic-induced apoptosis. J Cell Physiol. 2000 Jan;182(1):24-32. doi: 10.1002/(SICI)1097-4652(200001)182:1<24::AID-JCP3>3.0.CO;2-6.
563 mRNA expression analysis of a variety of apoptosis-related genes, including the novel gene of the BCL2-family, BCL2L12, in HL-60 leukemia cells after treatment with carboplatin and doxorubicin. Biol Chem. 2004 Nov;385(11):1099-103. doi: 10.1515/BC.2004.143.
564 Endoplasmic reticulum stress-mediated apoptosis in imatinib-resistant leukemic K562-r cells triggered by AMN107 combined with arsenic trioxide. Exp Biol Med (Maywood). 2013 Aug 1;238(8):932-42. doi: 10.1177/1535370213492689. Epub 2013 Jul 24.
565 Cotreatment with vorinostat (suberoylanilide hydroxamic acid) enhances activity of dasatinib (BMS-354825) against imatinib mesylate-sensitive or imatinib mesylate-resistant chronic myelogenous leukemia cells. Clin Cancer Res. 2006 Oct 1;12(19):5869-78. doi: 10.1158/1078-0432.CCR-06-0980.
566 Sorafenib induces apoptosis specifically in cells expressing BCR/ABL by inhibiting its kinase activity to activate the intrinsic mitochondrial pathway. Cancer Res. 2009 May 1;69(9):3927-36. doi: 10.1158/0008-5472.CAN-08-2978. Epub 2009 Apr 14.
567 Pleiotropic combinatorial transcriptomes of human breast cancer cells exposed to mixtures of dietary phytoestrogens. Food Chem Toxicol. 2009 Apr;47(4):787-95.
568 Efficacy of the polo-like kinase inhibitor rigosertib, alone or in combination with Abelson tyrosine kinase inhibitors, against break point cluster region-c-Abelson-positive leukemia cells. Oncotarget. 2015 Aug 21;6(24):20231-40. doi: 10.18632/oncotarget.4047.
569 Effect of aflatoxin B(1), benzo[a]pyrene, and methapyrilene on transcriptomic and epigenetic alterations in human liver HepaRG cells. Food Chem Toxicol. 2018 Nov;121:214-223. doi: 10.1016/j.fct.2018.08.034. Epub 2018 Aug 26.
570 A multi-parameter in vitro screen in human stem cell-derived cardiomyocytes identifies ponatinib-induced structural and functional cardiac toxicity. Toxicol Sci. 2015 Jan;143(1):147-55. doi: 10.1093/toxsci/kfu215. Epub 2014 Oct 10.
571 Cannabidiol Modulates the Expression of Alzheimer's Disease-Related Genes in Mesenchymal Stem Cells. Int J Mol Sci. 2016 Dec 23;18(1):26. doi: 10.3390/ijms18010026.
572 Effects and mechanisms of betulinic acid on improving EGFR TKI-resistance of lung cancer cells. Environ Toxicol. 2018 Nov;33(11):1153-1159.
573 The protective effects of liraglutide on AD-like neurodegeneration induced by oxidative stress in human neuroblastoma SH-SY5Y cells. Chem Biol Interact. 2019 Sep 1;310:108688. doi: 10.1016/j.cbi.2019.06.001. Epub 2019 Jun 4.
574 Dysregulation of integrin-linked kinase (ILK) signaling in colonic polyposis. Oncogene. 2001 Sep 27;20(43):6250-7. doi: 10.1038/sj.onc.1204791.
575 Differential effects of simvastatin and pravastatin on expression of Alzheimer's disease-related genes in human astrocytes and neuronal cells. J Lipid Res. 2009 Oct;50(10):2095-102. doi: 10.1194/jlr.M900236-JLR200. Epub 2009 May 21.
576 Quercetin potentiates apoptosis by inhibiting nuclear factor-kappaB signaling in H460 lung cancer cells. Biol Pharm Bull. 2013;36(6):944-51. doi: 10.1248/bpb.b12-01004.
577 Suppression of NF-kappaB and GSK-3beta is involved in colon cancer cell growth inhibition by the PPAR agonist troglitazone. Chem Biol Interact. 2010 Oct 6;188(1):75-85. doi: 10.1016/j.cbi.2010.06.001. Epub 2010 Jun 9.
578 NGBR is required to ameliorate type 2 diabetes in mice by enhancing insulin sensitivity. J Biol Chem. 2021 Jan-Jun;296:100624. doi: 10.1016/j.jbc.2021.100624. Epub 2021 Apr 2.
579 Epinephrine facilitates the growth of T cell lymphoma by altering cell proliferation, apoptosis, and glucose metabolism. Chem Biol Interact. 2023 Jan 5;369:110278. doi: 10.1016/j.cbi.2022.110278. Epub 2022 Nov 22.
580 Systematic identification of arsenic-binding proteins reveals that hexokinase-2 is inhibited by arsenic. Proc Natl Acad Sci U S A. 2015 Dec 8;112(49):15084-9. doi: 10.1073/pnas.1521316112. Epub 2015 Nov 23.
581 Ivermectin accelerates autophagic death of glioma cells by inhibiting glycolysis through blocking GLUT4 mediated JAK/STAT signaling pathway activation. Environ Toxicol. 2022 Apr;37(4):754-764. doi: 10.1002/tox.23440. Epub 2021 Dec 14.
582 The effects of rosiglitazone on fatty acid and triglyceride metabolism in type 2 diabetes. Diabetologia. 2005 Jan;48(1):83-95. doi: 10.1007/s00125-004-1619-9. Epub 2004 Dec 24.
583 Cannabidiol Reduces Leukemic Cell Size - But Is It Important?. Front Pharmacol. 2017 Mar 24;8:144. doi: 10.3389/fphar.2017.00144. eCollection 2017.
584 Crizotinib-resistant mutants of EML4-ALK identified through an accelerated mutagenesis screen. Chem Biol Drug Des. 2011 Dec;78(6):999-1005. doi: 10.1111/j.1747-0285.2011.01239.x. Epub 2011 Oct 31.
585 Potential anti-aging agents suppress the level of constitutive mTOR- and DNA damage- signaling. Aging (Albany NY). 2012 Dec;4(12):952-65. doi: 10.18632/aging.100521.
586 Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21.
587 NRF2 transcriptionally activates the heat shock factor 1 promoter under oxidative stress and affects survival and migration potential of MCF7 cells. J Biol Chem. 2018 Dec 14;293(50):19303-19316. doi: 10.1074/jbc.RA118.003376. Epub 2018 Oct 11.
588 A Gene Expression Biomarker Predicts Heat Shock Factor 1 Activation in a Gene Expression Compendium. Chem Res Toxicol. 2021 Jul 19;34(7):1721-1737. doi: 10.1021/acs.chemrestox.0c00510. Epub 2021 Jun 25.
589 Non-steroidal anti-inflammatory drugs inhibit the expression of cytokines and induce HSP70 in human monocytes. Cytokine. 1999 May;11(5):347-58. doi: 10.1006/cyto.1998.0437.
590 Simvastatin induces heat shock factor 1 in vascular endothelial cells. Atherosclerosis. 2006 Oct;188(2):265-73. doi: 10.1016/j.atherosclerosis.2005.10.045. Epub 2005 Dec 20.
591 Suppression of RAGE as a basis of simvastatin-dependent plaque stabilization in type 2 diabetes. Arterioscler Thromb Vasc Biol. 2006 Dec;26(12):2716-23.
592 Peroxisome proliferator-activated receptor-gamma agonists inhibit respiratory syncytial virus-induced expression of intercellular adhesion molecule-1 in human lung epithelial cells. Immunology. 2007 May;121(1):71-81. doi: 10.1111/j.1365-2567.2006.02539.x.
593 Glucosamine regulation of LPS-mediated inflammation in human bronchial epithelial cells. Eur J Pharmacol. 2010 Jun 10;635(1-3):219-26. doi: 10.1016/j.ejphar.2010.02.044. Epub 2010 Mar 20.
594 Effects of gonadotrophin-releasing hormone agonists on apoptosis of granulosa cells. Ann N Y Acad Sci. 2005 May;1042:531-7. doi: 10.1196/annals.1338.065.
595 BMN 673 (talazoparib): A potent PARP inhibitor for triple negative breast cancer with different genetic profile. J Biochem Mol Toxicol. 2019 May;33(5):e22286. doi: 10.1002/jbt.22286. Epub 2019 Jan 23.
596 Combining kallistatin gene therapy and meloxicam to treat hepatocellular carcinoma in mice. Cancer Sci. 2009 Nov;100(11):2226-33. doi: 10.1111/j.1349-7006.2009.01306.x. Epub 2009 Aug 4.
597 Expression of the retinoic acid-metabolizing enzyme CYP26A1 limits programmed cell death. Mol Pharmacol. 2005 May;67(5):1808-17. doi: 10.1124/mol.104.005769. Epub 2005 Feb 9.
598 Role of BAX in the apoptotic response to anticancer agents. Science. 2000 Nov 3;290(5493):989-92. doi: 10.1126/science.290.5493.989.
599 Mechanisms of thymidine kinase/ganciclovir and cytosine deaminase/ 5-fluorocytosine suicide gene therapy-induced cell death in glioma cells. Oncogene. 2005 Feb 10;24(7):1231-43. doi: 10.1038/sj.onc.1208290.
600 Simvastatin induces apoptosis in human colon cancer cells and in tumor xenografts, and attenuates colitis-associated colon cancer in mice. Int J Cancer. 2008 Aug 15;123(4):951-7. doi: 10.1002/ijc.23593.
601 The role of MITF and Mcl-1 proteins in the antiproliferative and proapoptotic effect of ciprofloxacin in amelanotic melanoma cells: In silico and in vitro study. Toxicol In Vitro. 2020 Aug;66:104884. doi: 10.1016/j.tiv.2020.104884. Epub 2020 May 8.
602 Quercetin downregulates Mcl-1 by acting on mRNA stability and protein degradation. Br J Cancer. 2011 Jul 12;105(2):221-30. doi: 10.1038/bjc.2011.229.
603 D-Penicillamine targets metastatic melanoma cells with induction of the unfolded protein response (UPR) and Noxa (PMAIP1)-dependent mitochondrial apoptosis. Apoptosis. 2012 Oct;17(10):1079-94.
604 Anti-cancer properties of glucosamine-hydrochloride in YD-8 human oral cancer cells: Induction of the caspase-dependent apoptosis and down-regulation of HIF-1. Toxicol In Vitro. 2012 Feb;26(1):42-50. doi: 10.1016/j.tiv.2011.10.005. Epub 2011 Oct 13.
605 Ethacrynic acid and a derivative enhance apoptosis in arsenic trioxide-treated myeloid leukemia and lymphoma cells: the role of glutathione S-transferase p1-1. Clin Cancer Res. 2012 Dec 15;18(24):6690-701. doi: 10.1158/1078-0432.CCR-12-0770. Epub 2012 Oct 18.
606 Identification of transcriptome signatures and biomarkers specific for potential developmental toxicants inhibiting human neural crest cell migration. Arch Toxicol. 2016 Jan;90(1):159-80.
607 JunD is involved in the antiproliferative effect of Delta9-tetrahydrocannabinol on human breast cancer cells. Oncogene. 2008 Aug 28;27(37):5033-44.
608 Comparison of the effects of metoclopramide and domperidone on HERG channels. Pharmacology. 2005 Apr;74(1):31-6. doi: 10.1159/000083234. Epub 2005 Jan 7.
609 Further insights into the effect of quinidine in short QT syndrome caused by a mutation in HERG. J Cardiovasc Electrophysiol. 2005 Jan;16(1):54-8. doi: 10.1046/j.1540-8167.2005.04470.x.
610 Automated tight seal electrophysiology for assessing the potential hERG liability of pharmaceutical compounds. Assay Drug Dev Technol. 2004 Oct;2(5):497-506. doi: 10.1089/adt.2004.2.497.
611 Refining the human iPSC-cardiomyocyte arrhythmic risk assessment model. Toxicol Sci. 2013 Dec;136(2):581-94. doi: 10.1093/toxsci/kft205. Epub 2013 Sep 19.
612 Pharmacology of the short QT syndrome N588K-hERG K+ channel mutation: differential impact on selected class I and class III antiarrhythmic drugs. Br J Pharmacol. 2008 Nov;155(6):957-66. doi: 10.1038/bjp.2008.325. Epub 2008 Aug 25.
613 Comparison of HERG channel blocking effects of various beta-blockers-- implication for clinical strategy. Br J Pharmacol. 2006 Mar;147(6):642-52. doi: 10.1038/sj.bjp.0706508.
614 Inhibitory effects of the class III antiarrhythmic drug amiodarone on cloned HERG potassium channels. Naunyn Schmiedebergs Arch Pharmacol. 1999 Mar;359(3):212-9. doi: 10.1007/pl00005344.
615 Redox state dependency of HERGS631C channel pharmacology: relation to C-type inactivation. FEBS Lett. 2000 May 26;474(1):111-5. doi: 10.1016/s0014-5793(00)01586-6.
616 Autophagy Inhibition Overcomes the Antagonistic Effect Between Gefitinib and Cisplatin in Epidermal Growth Factor Receptor Mutant Non--Small-Cell Lung Cancer Cells. Clin Lung Cancer. 2015 Sep;16(5):e55-66. doi: 10.1016/j.cllc.2015.03.006. Epub 2015 Apr 2.
617 Harnessing autophagy to overcome mitogen-activated protein kinase kinase inhibitor-induced resistance in metastatic melanoma. Br J Dermatol. 2019 Feb;180(2):346-356. doi: 10.1111/bjd.17333. Epub 2018 Nov 25.
618 Expression profile analysis of colon cancer cells in response to sulindac or aspirin. Biochem Biophys Res Commun. 2002 Mar 29;292(2):498-512.
619 Calcipotriol induces autophagy in HeLa cells and keratinocytes. J Invest Dermatol. 2011 Apr;131(4):990-3. doi: 10.1038/jid.2010.423. Epub 2011 Jan 13.
620 Multitarget effects of quercetin in leukemia. Cancer Prev Res (Phila). 2014 Dec;7(12):1240-50. doi: 10.1158/1940-6207.CAPR-13-0383. Epub 2014 Oct 7.
621 The antidepressants maprotiline and fluoxetine induce Type II autophagic cell death in drug-resistant Burkitt's lymphoma. Int J Cancer. 2011 Apr 1;128(7):1712-23. doi: 10.1002/ijc.25477. Epub 2010 May 25.
622 Autophagy contributes to 4-Amino-2-Trifluoromethyl-Phenyl Retinate-induced differentiation in human acute promyelocytic leukemia NB4 cells. Toxicol Appl Pharmacol. 2017 Mar 15;319:1-11. doi: 10.1016/j.taap.2017.01.016. Epub 2017 Jan 25.
623 Antitumor effect of arsenic trioxide in human K562 and K562/ADM cells by autophagy. Toxicol Mech Methods. 2012 Sep;22(7):512-9. doi: 10.3109/15376516.2012.686534. Epub 2012 May 22.
624 Inhibition of autophagy enhances Hydroquinone-induced TK6 cell death. Toxicol In Vitro. 2017 Jun;41:123-132. doi: 10.1016/j.tiv.2017.02.024. Epub 2017 Mar 2.
625 Vitamin D3 induces autophagy in human monocytes/macrophages via cathelicidin. Cell Host Microbe. 2009 Sep 17;6(3):231-43. doi: 10.1016/j.chom.2009.08.004.
626 Adaptive homeostasis of the vitamin D-vitamin D nuclear receptor axis in 8-methoxypsoralen-induced hepatotoxicity. Toxicol Appl Pharmacol. 2019 Jan 1;362:150-158. doi: 10.1016/j.taap.2018.11.002. Epub 2018 Nov 10.
627 A toxicogenomic approach to drug-induced phospholipidosis: analysis of its induction mechanism and establishment of a novel in vitro screening system. Toxicol Sci. 2005 Feb;83(2):282-92.
628 Time series analysis of oxidative stress response patterns in HepG2: a toxicogenomics approach. Toxicology. 2013 Apr 5;306:24-34.
629 Molecular mechanisms of hepatotoxic cholestasis by clavulanic acid: Role of NRF2 and FXR pathways. Food Chem Toxicol. 2021 Dec;158:112664. doi: 10.1016/j.fct.2021.112664. Epub 2021 Nov 9.
630 Determination of phospholipidosis potential based on gene expression analysis in HepG2 cells. Toxicol Sci. 2007 Mar;96(1):101-14.
631 Farnesoid X receptor induces murine scavenger receptor Class B type I via intron binding. PLoS One. 2012;7(4):e35895. doi: 10.1371/journal.pone.0035895. Epub 2012 Apr 23.
632 Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation. Blood. 2005 Jul 1;106(1):304-10.
633 Identification of mechanisms of action of bisphenol a-induced human preadipocyte differentiation by transcriptional profiling. Obesity (Silver Spring). 2014 Nov;22(11):2333-43.
634 Protective role of HO-1 for alcohol-dependent liver damage. Dig Dis. 2010;28(6):792-8. doi: 10.1159/000324287. Epub 2011 Apr 27.
635 Sertraline induces endoplasmic reticulum stress in hepatic cells. Toxicology. 2014 Aug 1;322:78-88. doi: 10.1016/j.tox.2014.05.007. Epub 2014 May 24.
636 Distinct Nrf2 Signaling Mechanisms of Fumaric Acid Esters and Their Role in Neuroprotection against 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Experimental Parkinson's-Like Disease. J Neurosci. 2016 Jun 8;36(23):6332-51. doi: 10.1523/JNEUROSCI.0426-16.2016.
637 Simvastatin protects dopaminergic neurons against MPP+-induced oxidative stress and regulates the endogenous anti-oxidant system through ERK. Cell Physiol Biochem. 2018;51(4):1957-1968.
638 P450 3A-catalyzed O-dealkylation of lapatinib induces mitochondrial stress and activates Nrf2. Chem Res Toxicol. 2016 May 16;29(5):784-96.
639 P21(Waf1/Cip1) plays a critical role in furazolidone-induced apoptosis in HepG2 cells through influencing the caspase-3 activation and ROS generation. Food Chem Toxicol. 2016 Feb;88:1-12. doi: 10.1016/j.fct.2015.12.004. Epub 2015 Dec 11.
640 Convergent transcriptional profiles induced by endogenous estrogen and distinct xenoestrogens in breast cancer cells. Carcinogenesis. 2006 Aug;27(8):1567-78.
641 Gene expression in endometrial cancer cells (Ishikawa) after short time high dose exposure to progesterone. Steroids. 2008 Jan;73(1):116-28.
642 In vitro aromatic bioactivation of the weak estrogen E(2)alpha and genesis of DNA adducts. Steroids. 2005 Mar;70(3):161-72. doi: 10.1016/j.steroids.2004.11.004.
643 Metabolism of melatonin by human cytochromes p450. Drug Metab Dispos. 2005 Apr;33(4):489-94.
644 Metabolism of retinoids and arachidonic acid by human and mouse cytochrome P450 1b1. Drug Metab Dispos. 2004 Aug;32(8):840-7.
645 Apoptosis contributes to the cytotoxicity induced by amodiaquine and its major metabolite N-desethylamodiaquine in hepatic cells. Toxicol In Vitro. 2020 Feb;62:104669. doi: 10.1016/j.tiv.2019.104669. Epub 2019 Oct 16.
646 Genetic variants contributing to daunorubicin-induced cytotoxicity. Cancer Res. 2008 May 1;68(9):3161-8. doi: 10.1158/0008-5472.CAN-07-6381.
647 Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
648 Repurposing L-menthol for systems medicine and cancer therapeutics? L-menthol induces apoptosis through caspase 10 and by suppressing HSP90. OMICS. 2016 Jan;20(1):53-64.
649 Drug-induced endoplasmic reticulum and oxidative stress responses independently sensitize toward TNF-mediated hepatotoxicity. Toxicol Sci. 2014 Jul;140(1):144-59. doi: 10.1093/toxsci/kfu072. Epub 2014 Apr 20.
650 Analysis of the in vitro synergistic effect of 5-fluorouracil and cisplatin on cervical carcinoma cells. Int J Gynecol Cancer. 2006 May-Jun;16(3):1321-9.
651 Pattern of expression of apoptosis and inflammatory genes in humans exposed to arsenic and/or fluoride. Sci Total Environ. 2010 Jan 15;408(4):760-7. doi: 10.1016/j.scitotenv.2009.11.016. Epub 2009 Dec 4.
652 AS3MT facilitates NLRP3 inflammasome activation by m(6)A modification during arsenic-induced hepatic insulin resistance. Cell Biol Toxicol. 2023 Oct;39(5):2165-2181. doi: 10.1007/s10565-022-09703-7. Epub 2022 Feb 28.
653 Primary Human Hepatocyte Spheroids as Tools to Study the Hepatotoxic Potential of Non-Pharmaceutical Chemicals. Int J Mol Sci. 2021 Oct 12;22(20):11005. doi: 10.3390/ijms222011005.
654 Pterostilbene attenuates RIPK3-dependent hepatocyte necroptosis in alcoholic liver disease via SIRT2-mediated NFATc4 deacetylation. Toxicology. 2021 Sep;461:152923. doi: 10.1016/j.tox.2021.152923. Epub 2021 Aug 30.
655 Prediction of drug-induced liver injury using keratinocytes. J Appl Toxicol. 2017 Jul;37(7):863-872. doi: 10.1002/jat.3435. Epub 2017 Jan 31.
656 Quantitative high-throughput profiling of environmental chemicals and drugs that modulate farnesoid X receptor. Sci Rep. 2014 Sep 26;4:6437. doi: 10.1038/srep06437.
657 Potency of individual bile acids to regulate bile acid synthesis and transport genes in primary human hepatocyte cultures. Toxicol Sci. 2014 Oct;141(2):538-46. doi: 10.1093/toxsci/kfu151. Epub 2014 Jul 23.
658 The farnesoid X receptor FXRalpha/NR1H4 acquired ligand specificity for bile salts late in vertebrate evolution. Am J Physiol Regul Integr Comp Physiol. 2007 Sep;293(3):R1400-9. doi: 10.1152/ajpregu.00781.2006. Epub 2007 Jun 13.
659 Organochloride pesticides modulated gut microbiota and influenced bile acid metabolism in mice. Environ Pollut. 2017 Jul;226:268-276.
660 Characterization of DOK1, a candidate tumor suppressor gene, in epithelial ovarian cancer. Mol Oncol. 2011 Oct;5(5):438-53. doi: 10.1016/j.molonc.2011.07.003. Epub 2011 Jul 26.
661 Identification of a transcriptomic signature of food-relevant genotoxins in human HepaRG hepatocarcinoma cells. Food Chem Toxicol. 2020 Jun;140:111297. doi: 10.1016/j.fct.2020.111297. Epub 2020 Mar 28.
662 Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761. doi: 10.1016/j.taap.2019.114761. Epub 2019 Sep 15.
663 Low Autophagy (ATG) Gene Expression Is Associated with an Immature AML Blast Cell Phenotype and Can Be Restored during AML Differentiation Therapy. Oxid Med Cell Longev. 2018 Mar 18;2018:1482795. doi: 10.1155/2018/1482795. eCollection 2018.
664 Inhibitory effect of PXR on ammonia-induced hepatocyte autophagy via P53. Toxicol Lett. 2018 Oct 1;295:153-161. doi: 10.1016/j.toxlet.2018.06.1066. Epub 2018 Jun 14.
665 TNF enhances trovafloxacin-induced in vitro hepatotoxicity by inhibiting protective autophagy. Toxicol Lett. 2021 May 15;342:73-84. doi: 10.1016/j.toxlet.2021.02.009. Epub 2021 Feb 17.
666 A high-throughput screen for teratogens using human pluripotent stem cells. Toxicol Sci. 2014 Jan;137(1):76-90. doi: 10.1093/toxsci/kft239. Epub 2013 Oct 23.
667 Antiepileptic drugs are endocrine disruptors for the human fetal testis ex vivo. Toxicol Sci. 2023 Sep 28;195(2):169-183. doi: 10.1093/toxsci/kfad076.
668 Gene expression profiling in Ishikawa cells: a fingerprint for estrogen active compounds. Toxicol Appl Pharmacol. 2009 Apr 1;236(1):85-96.
669 Role of transporter genes in cisplatin resistance. In Vivo. 2008 May-Jun;22(3):279-83.
670 Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.
671 Marine biogenics in sea spray aerosols interact with the mTOR signaling pathway. Sci Rep. 2019 Jan 24;9(1):675.
672 Transcriptional profiling of lactic acid treated reconstructed human epidermis reveals pathways underlying stinging and itch. Toxicol In Vitro. 2019 Jun;57:164-173.
673 Acetaldehyde inhibits PPARgamma via H2O2-mediated c-Abl activation in human hepatic stellate cells. Gastroenterology. 2006 Oct;131(4):1235-52. doi: 10.1053/j.gastro.2006.08.009.
674 Quantitative proteomic analysis of HepG2 cells treated with quercetin suggests IQGAP1 involved in quercetin-induced regulation of cell proliferation and migration. OMICS. 2009 Apr;13(2):93-103. doi: 10.1089/omi.2008.0075.
675 Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay. Toxicol Sci. 2015 Aug;146(2):311-20. doi: 10.1093/toxsci/kfv094. Epub 2015 May 15.
676 Triggering of transient receptor potential vanilloid type 1 (TRPV1) by capsaicin induces Fas/CD95-mediated apoptosis of urothelial cancer cells in an ATM-dependent manner. Carcinogenesis. 2009 Aug;30(8):1320-9. doi: 10.1093/carcin/bgp138. Epub 2009 Jun 5.
677 Monitoring of deiodinase deficiency based on transcriptomic responses in SH-SY5Y cells. Arch Toxicol. 2013 Jun;87(6):1103-13. doi: 10.1007/s00204-013-1018-4. Epub 2013 Feb 10.
678 Anti-proliferative and gene expression actions of resveratrol in breast cancer cells in vitro. Oncotarget. 2014 Dec 30;5(24):12891-907.
679 Novel ATP-competitive Akt inhibitor afuresertib suppresses the proliferation of malignant pleural mesothelioma cells. Cancer Med. 2017 Nov;6(11):2646-2659. doi: 10.1002/cam4.1179. Epub 2017 Sep 27.
680 Targeting MYCN in neuroblastoma by BET bromodomain inhibition. Cancer Discov. 2013 Mar;3(3):308-23.
681 Some HIV antiretrovirals increase oxidative stress and alter chemokine, cytokine or adiponectin production in human adipocytes and macrophages. Antivir Ther. 2007;12(4):489-500.
682 Oxidative Stress Alters miRNA and Gene Expression Profiles in Villous First Trimester Trophoblasts. Biomed Res Int. 2015;2015:257090. doi: 10.1155/2015/257090. Epub 2015 Aug 3.
683 Distinct vascular and metabolic effects of different classes of anti-hypertensive drugs. Int J Cardiol. 2010 Apr 1;140(1):73-81. doi: 10.1016/j.ijcard.2008.11.017. Epub 2008 Dec 6.
684 [Quercetin affects leptin and its receptor in human gastric cancer MGC-803 cells and JAK-STAT pathway]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2012 Jan;28(1):12-6.
685 Leptin production in adipocytes from morbidly obese subjects: stimulation by dexamethasone, inhibition with troglitazone, and influence of gender. J Clin Endocrinol Metab. 2000 Aug;85(8):2678-84. doi: 10.1210/jcem.85.8.6733.
686 Effects of nevirapine and efavirenz on human adipocyte differentiation, gene expression, and release of adipokines and cytokines. Antiviral Res. 2011 Aug;91(2):112-9. doi: 10.1016/j.antiviral.2011.04.018. Epub 2011 May 17.
687 The psychoactive compound of Cannabis sativa, (9)-tetrahydrocannabinol (THC) inhibits the human trophoblast cell turnover. Toxicology. 2015 Aug 6;334:94-103. doi: 10.1016/j.tox.2015.06.005. Epub 2015 Jun 9.
688 Amlodipine improves endothelial function and metabolic parameters in patients with hypertension. Int J Cardiol. 2009 Mar 20;133(1):23-31. doi: 10.1016/j.ijcard.2007.11.058. Epub 2008 Jan 15.
689 Leptomycin B reduces primary and acquired resistance of gefitinib in lung cancer cells. Toxicol Appl Pharmacol. 2017 Nov 15;335:16-27. doi: 10.1016/j.taap.2017.09.017. Epub 2017 Sep 21.
690 Assessment of the cytotoxic, genotoxic, and apoptotic potential of flurbiprofen in HeLa and HepG2 cell lines. J Biochem Mol Toxicol. 2021 Jun;35(6):1-11. doi: 10.1002/jbt.22770. Epub 2021 Mar 11.
691 Apoptotic induction by simvastatin in human lung cancer A549 cells via Akt signaling dependent down-regulation of survivin. Invest New Drugs. 2011 Oct;29(5):945-52. doi: 10.1007/s10637-010-9450-2. Epub 2010 May 13.
692 Combining lapatinib (GW572016), a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases, with therapeutic anti-ErbB2 antibodies enhances apoptosis of ErbB2-overexpressing breast cancer cells. Oncogene. 2005 Sep 15;24(41):6213-21. doi: 10.1038/sj.onc.1208774.
693 Quercetin inhibit human SW480 colon cancer growth in association with inhibition of cyclin D1 and survivin expression through Wnt/beta-catenin signaling pathway. Cancer Invest. 2009 Jul;27(6):604-12. doi: 10.1080/07357900802337191.
694 Troglitazone sensitizes tumor cells to TRAIL-induced apoptosis via down-regulation of FLIP and Survivin. Apoptosis. 2006 Sep;11(9):1503-12. doi: 10.1007/s10495-006-8896-3.
695 Selenium sensitizes MCF-7 breast cancer cells to doxorubicin-induced apoptosis through modulation of phospho-Akt and its downstream substrates. Mol Cancer Ther. 2007 Mar;6(3):1031-8. doi: 10.1158/1535-7163.MCT-06-0643. Epub 2007 Mar 5.
696 Quercetin induced cell apoptosis and altered gene expression in AGS human gastric cancer cells. Environ Toxicol. 2018 Nov;33(11):1168-1181. doi: 10.1002/tox.22623. Epub 2018 Aug 27.
697 An in vitro study on anti-carcinogenic effect of remdesivir in human ovarian cancer cells via generation of reactive oxygen species. Hum Exp Toxicol. 2022 Jan-Dec;41:9603271221089257. doi: 10.1177/09603271221089257.
698 Antitumor action of the MET tyrosine kinase inhibitor crizotinib (PF-02341066) in gastric cancer positive for MET amplification. Mol Cancer Ther. 2012 Jul;11(7):1557-64. doi: 10.1158/1535-7163.MCT-11-0934. Epub 2012 Jun 22.
699 Arsenic trioxide induces different gene expression profiles of genes related to growth and apoptosis in glioma cells dependent on the p53 status. Mol Biol Rep. 2008 Sep;35(3):421-9.
700 Aspirin induces apoptosis in human leukemia cells independently of NF-kappaB and MAPKs through alteration of the Mcl-1/Noxa balance. Apoptosis. 2010 Feb;15(2):219-29. doi: 10.1007/s10495-009-0424-9.
701 Comparison of the gene expression profiles of monocytic versus granulocytic lineages of HL-60 leukemia cell differentiation by DNA microarray analysis. Life Sci. 2003 Aug 15;73(13):1705-19. doi: 10.1016/s0024-3205(03)00515-0.
702 Effect of retinoic acid on gene expression in human conjunctival epithelium: secretory phospholipase A2 mediates retinoic acid induction of MUC16. Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4050-61.
703 PLK1 targets NOTCH1 during DNA damage and mitotic progression. J Biol Chem. 2019 Nov 22;294(47):17941-17950. doi: 10.1074/jbc.RA119.009881. Epub 2019 Oct 9.