Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMPM4SK)

• Drug Name: Methamphetamine Drug Info
• Synonyms: METHAMPHETAMINE; Metamfetamine; d-Deoxyephedrine; d-Desoxyephedrine; d-Methamphetamine; d-N-Methylamphetamine; Metamphetamine; L-Methamphetamine; d-Methylamphetamine; Methylamphetamine; d-Phenylisopropylmethylamine; N-Methylamphetamine; (S)-Methamphetamine; Norodin; (+)-Methylamphetamine; d-(S)-Methamphetamine; D-1-Phenyl-2-methylaminopropane; Metamfetaminum; Desyphed; (+)-N-Methylamphetamine; (S)-Methylamphetamine; (+)-(S)-Deoxyephedrine; Methyl-beta-phenylisopropylamine; 1-Phenyl-2-methylaminopropane; (S)-(+)-Deoxyephedrine; Crank; Desohyephedrine; Metamfetamina; Meth; Methamphetaminum; Speed; Stimulex; Crank [Street Name]; Crystal Meth; Crystal Meth [Street Name]; Desyphed hydrochloride; ICE [Street Name]; Metamfetamine [INN];Metamfetaminum [Latin]; Metanfetamina [Spanish]; Methamphetaminum [JP]; Speed [Street Name]; D-Deoxyephedrine; D-Desoxyephedrine; D-Methamphetamine; D-Methylamphetamine; D-Phenylisopropylmethylamine;Desoxyn (TN); Metamfetamina [INN-Spanish]; Metamfetamine (INN); Metamfetamine-m; Metamfetaminum [INN-Latin]; Metanfetamina [INN-Spanish]; Meth (Street Name); Methamphetaminum [INN-Latin]; D-N-Methylamphetamine; D-(S)-Methamphetamine; D-N,alpha-dimethylphenethylamine; Methamphetamine, its salts, isomers, and salts of its isomers; N-Methyl-beta-phenylisopropylamin; N-Methyl-beta-phenylisopropylamin [German]; N-Methyl-beta-phenylisopropylamine; D-1-Phenyl-2-methylaminopropan; D-1-Phenyl-2-methylaminopropan [German]; S-(+)-Methamphetamine; D-N,alpha-Dimethylphenethylamine; N-Methyl-1-phenyl-2-propanamine; Benzeneethanamine, N,alpha-dimethyl-, (S)-(9CI); Benzeneethanamine, N,alpha-dimethyl-, (alphaS)-(9CI); Phenethylamine, N,alpha-dimethyl-, (S)-(+)-(8CI); (+)-(S)-N-alpha-Dimethylphenethylamine; (+)-2-(N-Methylamino)-1-phenylpropane; (+)-N,alpha-Dimethyl-beta-phenylethylamine; (+)-N,alpha-Dimethylphenethylamine; (+)-methamphetamine; (2S)-N-methyl-1-phenylpropan-2-amine; (S)-(+)-Methamphetamine; (S)-(+)-N,alpha,dimethylphenethylamine; (S)-N,alpha-Dimethylbenzeneethanamine; (S)-N,alpha-Dimethylbenzeneethanoamine; (alphaS)-N,alpha-dimethylbenzeneethanamine; 1-Phenyl-2-methylamino-propan; 1-Phenyl-2-methylamino-propan [German]; 2S-(+)-Methamphetamine; Methamfetamine

Indication

Disease Entry	ICD 11	Status	REF
Anxiety		Approved	[1]
Attention deficit hyperactivity disorder	6A05.Z	Approved	[2]
Depression	6A70-6A7Z	Approved	[1]
Methamphetamine dependence	6C46.2	Approved	[1]
Obesity	5B81	Approved	[1]
Pain	MG30-MG3Z	Approved	[3]
Sexually transmitted infection	1A9Z	Approved	[1]
Substance dependence		Approved	[1]

• Therapeutic Class: Central Nervous System Stimulants
• Cross-matching ID:
  PubChem CID: 10836
  ChEBI ID: CHEBI:6809
  CAS Number: CAS 537-46-2
  TTD Drug ID: DMPM4SK
  VARIDT Drug ID: DR00256
  INTEDE Drug ID: DR1036
  ACDINA Drug ID: D00207

Molecule-Related Drug Atlas

Drug(s) Targeting Adrenergic receptor alpha-1B (ADRA1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Propericiazine	DME9JNL	Psychiatric disorder	6E8Z	Approved	[12]
Methoxamine	DMF5XQH	Hypertension	BA00-BA04	Approved	[13]
Phendimetrazine	DM6TS1N	Obesity	5B81	Approved	[14]
MEDETOMIDINE	DMX9Y7V	Pain	MG30-MG3Z	Phase 2	[15]
TIOSPIRONE	DME5QDP	N. A.	N. A.	Discontinued in Phase 3	[16]
Sunepitron	DM6M8ZX	N. A.	N. A.	Discontinued in Phase 3	[17]
MAZAPERTINE	DMRHYAU	N. A.	N. A.	Discontinued in Phase 2	[18]
SOU-001	DMPAEK5	Urinary incontinence	MF50.2	Discontinued in Phase 2	[19]
SNAP-5089	DMROJEN	Heart arrhythmia	BC65	Terminated	[20]
WB-4101	DMQU8B1	N. A.	N. A.	Terminated	[21]

Drug(s) Targeting Dopamine D2 receptor (D2R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[22]
Haloperidol	DM96SE0	Delirium		Approved	[23]
Perphenazine	DMA4MRX	Schizophrenia	6A20	Approved	[24]
Perazine	DM2AOTZ	Psychotic disorder	6A20-6A25	Approved	[25]
Domperidone	DMBDPY0	Gastrointestinal disease	DE2Z	Approved	[26]
Levodopa	DMN3E57	Parkinson disease	8A00.0	Approved	[27]
Quetiapine	DM1N62C	Anorexia nervosa cachexia	6B80	Approved	[28]
Pimozide	DMW83TP	Schizophrenia	6A20	Approved	[29]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[30]
Iloperidone	DM6AUFY	Schizophrenia	6A20	Approved	[31]

Drug(s) Transported By Vesicular amine transporter 2 (SLC18A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[32]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[33]
Norepinephrine	DMOUC09	Alopecia	ED70	Approved	[32]
SEROTONIN	DMOFCRY	Discovery agent	N.A.	Investigative	[32]

Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[34]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[35]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[36]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[37]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[38]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[39]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[40]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[41]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[42]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[43]

Drug(s) Affected By Synaptic vesicular amine transporter (SLC18A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Norepinephrine	DMOUC09	Alopecia	ED70	Approved	[44]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[44]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[45]
Haloperidol	DM96SE0	Delirium		Approved	[45]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Dextroamphetamine	DMMIHVP	Attention deficit hyperactivity disorder	6A05.Z	Approved	[45]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[48]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[49]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[50]

Drug(s) Affected By D(2) dopamine receptor (DRD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Droperidol	DM0DXA8	Nausea	MD90	Approved	[51]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[51]
Zuclopenthixol	DMKYD5N	Schizophrenia	6A20	Approved	[51]
Meglitinides	DM1OFHN	Type-2 diabetes	5A11	Approved	[52]
Sulpiride	DMF54ZG	Schizophrenia	6A20	Approved	[53]
Risperidone	DMN6DXL	Bipolar I disorder		Approved	[54]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[55]
Bromocriptine	DMVE3TK	Acromegaly	5A60.0	Approved	[56]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[57]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[58]

Drug(s) Affected By PRKCA-binding protein (PICK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[59]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[60]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[62]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[63]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[64]

Drug(s) Affected By Zeta-sarcoglycan (SGCZ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[65]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[64]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[65]

Drug(s) Affected By Cytosolic carboxypeptidase 4 (AGBL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[66]
Chlorothiazide	DMLHESP	Chronic heart failure	BD1Z	Approved	[67]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[65]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[69]

Drug(s) Affected By Catalase (CAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[70]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[71]
Haloperidol	DM96SE0	Delirium		Approved	[51]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[72]
Selenium	DM25CGV	N. A.	N. A.	Approved	[73]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[74]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[75]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[76]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[77]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]

Drug(s) Affected By Superoxide dismutase (SOD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[79]
Haloperidol	DM96SE0	Delirium		Approved	[51]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[80]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[81]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[70]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[82]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[83]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[84]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[85]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[86]

Drug(s) Affected By Metallothionein-2 (MT2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[87]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[88]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[89]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[90]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[91]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[92]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[93]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[95]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[96]

Drug(s) Affected By Activator of apoptosis harakiri (HRK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[93]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[66]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[97]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[46]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[93]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[99]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[100]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[101]

Drug(s) Affected By Angiopoietin-2 (ANGPT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[102]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[103]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[104]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[66]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[105]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[106]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[107]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[108]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[108]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[109]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[110]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[111]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[112]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[113]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[114]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[115]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[116]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[117]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[118]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[119]

Drug(s) Affected By Cell division control protein 45 homolog (CDC45)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[120]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[121]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[122]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[124]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[125]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[108]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[108]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[126]

Drug(s) Affected By Retinal dehydrogenase 2 (ALDH1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[127]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[127]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[127]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[66]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[127]
Nilotinib	DM7HXWT	Chronic myelogenous leukaemia	2A20.0	Approved	[127]
Ramelteon	DM7IW9J	Insomnia	7A00-7A0Z	Approved	[127]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[128]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Dabigatran	DMDI6R4	Stroke	8B20	Approved	[127]

Drug(s) Affected By BAI1-associated protein 3 (BAIAP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[129]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[130]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[131]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[64]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[65]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[132]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[133]

Drug(s) Affected By Dickkopf-related protein 1 (DKK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[89]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[134]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[136]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[137]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[138]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[46]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[140]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[141]

Drug(s) Affected By G2/mitotic-specific cyclin-B2 (CCNB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[120]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[110]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[143]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[145]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[136]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[108]

Drug(s) Affected By Kinesin-like protein KIF20A (KIF20A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[146]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[147]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[143]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[148]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[108]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[108]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[46]

Drug(s) Affected By ATP-binding cassette sub-family C member 6 (ABCC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzbromarone	DMC3YUA	Gout	FA25	Approved	[149]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[149]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[150]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[151]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[152]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[153]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[154]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]

Drug(s) Affected By Keratin, type I cytoskeletal 14 (KRT14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[155]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[156]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[156]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[157]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[158]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[141]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[159]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[156]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[160]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[161]

Drug(s) Affected By C-X-C motif chemokine 10 (CXCL10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[162]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[163]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[148]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[164]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[165]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[167]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]

Drug(s) Affected By Fatty acid-binding protein, heart (FABP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[168]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[169]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[66]
Haloperidol	DM96SE0	Delirium		Approved	[170]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[171]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[140]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[96]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[170]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[172]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[173]

Drug(s) Affected By DNA topoisomerase 2-alpha (TOP2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[174]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[175]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[81]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[176]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[143]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[177]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[178]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[179]

Drug(s) Affected By High mobility group protein HMG-I/HMG-Y (HMGA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[180]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[148]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[141]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[181]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[101]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[60]

Drug(s) Affected By C-X-C motif chemokine 2 (CXCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[88]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Selenium	DM25CGV	N. A.	N. A.	Approved	[182]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[183]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[123]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[184]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[125]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[185]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[171]

Drug(s) Affected By Galanin peptides (GAL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[186]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[186]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[187]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[188]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[95]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[108]
Methazolamide	DM7J2TA	Glaucoma/ocular hypertension	9C61	Approved	[186]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[108]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[171]

Drug(s) Affected By Ribonucleoside-diphosphate reductase subunit M2 (RRM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[189]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[120]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[143]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[178]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[190]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[95]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[108]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[108]

Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[191]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[192]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[193]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[194]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[195]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[196]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[197]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[198]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[199]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]

Drug(s) Affected By Phospholipase A2 group V (PLA2G5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[201]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[202]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[203]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[63]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[202]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[64]
SB-203347	DM3AWMF	Discovery agent	N.A.	Investigative	[204]
Beta-D-Glucose	DM5IHYP	Discovery agent	N.A.	Investigative	[205]
fMet-Leu-Phe	DMQ391A	N. A.	N. A.	Investigative	[205]

Drug(s) Affected By Thrombopoietin (THPO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[206]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[140]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[101]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[207]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[62]
Testosterone undecanoate	DMZO10Y	Hypogonadism	5A61.0	Approved	[208]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[209]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[51]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[130]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[210]

Drug(s) Affected By DNA-binding protein inhibitor ID-1 (ID1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[211]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[212]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[180]
Selenium	DM25CGV	N. A.	N. A.	Approved	[213]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[124]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[214]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[215]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[138]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[46]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]

Drug(s) Affected By Proliferation marker protein Ki-67 (MKI67)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[216]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[143]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[217]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[218]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[219]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[145]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[220]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[221]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[138]

Drug(s) Affected By N-acylglucosamine 2-epimerase (RENBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[222]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[59]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[223]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[223]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[209]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[130]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[224]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[64]

Drug(s) Affected By Actin, alpha cardiac muscle 1 (ACTC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[140]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[225]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[226]
Estriol	DMOEM2I	Hormone deficiency	5A61.1	Approved	[227]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[101]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[227]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[228]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[63]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[129]

Drug(s) Affected By Mevalonate kinase (MVK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[213]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[229]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[168]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[230]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[150]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[148]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[188]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[231]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[173]

Drug(s) Affected By Origin recognition complex subunit 1 (ORC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[88]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[104]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[145]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[108]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[108]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[232]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[126]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[233]

Drug(s) Affected By Transmembrane glycoprotein NMB (GPNMB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[218]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[190]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[96]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[126]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[234]

Drug(s) Affected By PCNA-associated factor (PCLAF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[146]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[143]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[235]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[95]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[108]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[108]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[236]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[141]

Drug(s) Affected By Disks large-associated protein 5 (DLGAP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[237]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[143]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[148]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[108]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[108]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[46]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[96]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[96]

Drug(s) Affected By Centrosomal protein of 55 kDa (CEP55)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[105]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[108]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[238]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[236]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[239]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[234]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[240]

Drug(s) Affected By Borealin (CDCA8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[108]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[108]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[46]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[232]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[236]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[234]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[233]

Drug(s) Affected By Solute carrier organic anion transporter family member 4C1 (SLCO4C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[104]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[188]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[66]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[140]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[126]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[234]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[240]

Drug(s) Affected By Protein MCM10 homolog (MCM10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[120]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[147]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[218]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[108]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[108]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[232]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[238]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[236]

Drug(s) Affected By Ras guanyl-releasing protein 3 (RASGRP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[241]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[61]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[242]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[63]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[64]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[243]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[244]

Drug(s) Affected By Abnormal spindle-like microcephaly-associated protein (ASPM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[143]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[148]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[105]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[245]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[108]
Riboflavin	DM8YMWE	Acne vulgaris	ED80	Approved	[246]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[108]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[46]

Drug(s) Affected By CD177 antigen (CD177)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[247]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[64]

Drug(s) Affected By Holliday junction recognition protein (HJURP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[218]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[248]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[108]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[108]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[232]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[140]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[236]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[226]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[249]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[61]

Drug(s) Affected By SHC SH2 domain-binding protein 1 (SHCBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[201]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[148]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[108]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[108]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[250]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[141]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[226]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[240]

Drug(s) Affected By Interferon-stimulated gene 20 kDa protein (ISG20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[184]
Aripiprazole	DM3NUMH	Bipolar I disorder		Approved	[251]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[148]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[184]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[108]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[108]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[150]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[59]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[184]

Drug(s) Affected By RAD51-associated protein 1 (RAD51AP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[80]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[148]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[108]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[108]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[250]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[236]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[240]

Drug(s) Affected By Lymphokine-activated killer T-cell-originated protein kinase (PBK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[143]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[148]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[252]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[108]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[108]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[46]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[140]

Drug(s) Affected By Growth/differentiation factor 15 (GDF15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[253]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[89]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[147]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[115]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[254]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[255]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[156]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[156]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[256]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[257]

Drug(s) Affected By Kinesin-like protein KIFC1 (KIFC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[201]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[148]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[108]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[108]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[46]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[232]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[236]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[141]

Drug(s) Affected By Denticleless protein homolog (DTL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[148]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[258]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[108]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[108]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[126]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[259]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[226]

Drug(s) Affected By Adherens junction-associated protein 1 (AJAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[183]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[66]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[260]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[66]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[161]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[66]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[64]
PMID27336223-Compound-5	DM6E50A	N. A.	N. A.	Patented	[260]

Drug(s) Affected By 2-oxoglutarate dehydrogenase-like, mitochondrial (OGDHL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[148]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[261]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[141]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[234]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[101]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[142]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[62]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[63]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[66]

Drug(s) Affected By Lymphocyte antigen 96 (LY96)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[262]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[263]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[76]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[150]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[190]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[215]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[108]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[108]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]

Drug(s) Affected By Protein kinase C delta type (PRKCD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[93]
Butorphanol	DM5KYPJ	Pain	MG30-MG3Z	Approved	[264]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[265]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[266]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[267]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[138]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[268]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[238]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[269]

Drug(s) Affected By Bcl-2-like protein 11 (BCL2L11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[270]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[271]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[134]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[148]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[219]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[272]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[66]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[273]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[274]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[268]

Drug(s) Affected By E3 ubiquitin-protein ligase parkin (PRKN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Emtricitabine	DMBMUWZ	Hepatitis virus infection	1E50-1E51	Approved	[275]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[276]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[277]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[278]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[279]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[280]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[61]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[63]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[276]

Drug(s) Affected By Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[281]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[282]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[283]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[284]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[285]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[284]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[286]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[287]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[284]

Drug(s) Affected By Prolactin (PRL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[288]
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[289]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[290]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[291]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[76]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[292]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[293]
Aripiprazole	DM3NUMH	Bipolar I disorder		Approved	[294]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[295]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[296]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[297]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[298]
Fructose	DM43AN2	Vomiting	MD90	Approved	[51]
Ketoprofen	DMRKXPT	Bursitis		Approved	[51]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[299]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[300]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[301]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[302]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[303]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[102]

Drug(s) Affected By T-cell surface glycoprotein CD3 delta chain (CD3D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[148]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[188]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[252]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[101]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]
Nabiximols	DMHKJ5I	Cancer related pain	MG30	Phase 3	[305]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[306]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[139]

Drug(s) Affected By Amyloid-beta precursor protein (APP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[180]
Selenium	DM25CGV	N. A.	N. A.	Approved	[213]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[76]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[307]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[123]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[308]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[309]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[310]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[105]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[311]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[312]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[313]
Fructose	DM43AN2	Vomiting	MD90	Approved	[51]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[314]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[315]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[282]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[81]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[222]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[316]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[317]

Drug(s) Affected By Insulin receptor (INSR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[318]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[76]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[187]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[319]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[320]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[321]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[322]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[323]

Drug(s) Affected By Tyrosine 3-monooxygenase (TH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zonisamide	DM0DTF7	Alcohol dependence	6C40.2	Approved	[324]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[325]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[326]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[327]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[171]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[238]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[328]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[329]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[330]
Piperazine	DMTY9LU	Ascariasis	1F62	Approved	[331]

Drug(s) Affected By Synaptophysin (SYP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[180]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[329]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[171]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[332]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[329]
Abacavir	DMMN36E	Human immunodeficiency virus infection	1C62	Approved	[333]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[241]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[62]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[130]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[88]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[334]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[335]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[113]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[336]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[337]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[336]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[338]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[339]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[340]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[341]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[342]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[343]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[344]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[51]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[88]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[345]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[346]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[300]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[347]

Drug(s) Affected By Microtubule-associated protein tau (MAPT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[348]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[349]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[350]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[351]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[352]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[148]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[353]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[46]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[354]

Drug(s) Affected By Endoplasmic reticulum chaperone BiP (HSPA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[348]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[284]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[355]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[356]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[357]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[358]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[359]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[360]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[361]

Drug(s) Affected By Cyclic AMP-responsive element-binding protein 1 (CREB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[362]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[363]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[222]
Selenium	DM25CGV	N. A.	N. A.	Approved	[213]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[364]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[365]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[366]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[366]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[367]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[368]

Drug(s) Affected By Protein kinase C alpha type (PRKCA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[369]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[370]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[230]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[148]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[66]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[371]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[141]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[372]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-4 (ATF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[282]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[373]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[180]
Selenium	DM25CGV	N. A.	N. A.	Approved	[213]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[115]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[286]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[287]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[374]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[375]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[376]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-6 alpha (ATF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[284]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[134]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[284]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[104]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[286]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[377]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[374]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[284]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[378]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[379]

Drug(s) Affected By Troponin I, cardiac muscle (TNNI3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[380]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[115]
Perphenazine	DMA4MRX	Schizophrenia	6A20	Approved	[381]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[382]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[223]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[241]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[383]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[62]

Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[384]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[257]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[282]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[385]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[180]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[386]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[84]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[387]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[388]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[122]

Drug(s) Affected By D(1A) dopamine receptor (DRD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[51]
Haloperidol	DM96SE0	Delirium		Approved	[389]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[390]
Pergolide mesylate	DM5GKOV	N. A.	N. A.	Approved	[391]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[389]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[392]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[393]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[394]
Bardoxolone methyl	DMODA2X	Mixed connective tissue disease	4A43.3	Phase 3	[395]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fructose	DM43AN2	Vomiting	MD90	Approved	[396]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[178]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[397]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[215]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[398]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[126]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[399]
Mirtazapine	DML53ZJ	Depression	6A70-6A7Z	Approved	[400]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[60]

Drug(s) Affected By NF-kappa-B inhibitor alpha (NFKBIA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fructose	DM43AN2	Vomiting	MD90	Approved	[51]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[401]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[262]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[402]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[350]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[403]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[404]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[405]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[406]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[407]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[408]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[363]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[300]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[409]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[410]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[411]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[412]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[413]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[414]

Drug(s) Affected By Choline O-acetyltransferase (CHAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[329]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[329]
Scopolamine	DMOM8AL	Addictive disorder	6C50-6C5Z	Approved	[415]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[209]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[51]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[64]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[416]
2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE	DMNQL17	Discovery agent	N.A.	Investigative	[417]
Elaidoylamide	DMP8VDT	Discovery agent	N.A.	Investigative	[418]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[419]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[408]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[420]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[421]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[422]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[407]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[51]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[262]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[300]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[409]

Drug(s) Affected By Sodium-dependent serotonin transporter (SLC6A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paroxetine	DM5PVQE	Anxiety disorder	6B00-6B0Z	Approved	[423]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[424]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[425]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[426]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[427]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Aripiprazole	DM3NUMH	Bipolar I disorder		Approved	[428]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[426]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]

Drug(s) Affected By D(3) dopamine receptor (DRD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Haloperidol	DM96SE0	Delirium		Approved	[429]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[430]
Risperidone	DMN6DXL	Bipolar I disorder		Approved	[431]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[432]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[433]
Droperidol	DM0DXA8	Nausea	MD90	Approved	[51]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[51]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[51]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[51]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[51]

Drug(s) Affected By Insulin receptor substrate 1 (IRS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[434]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[105]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[215]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[435]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[398]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[46]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[140]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[253]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[436]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[282]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[373]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[284]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[89]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[357]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[437]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[143]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]

Drug(s) Affected By Serine/threonine-protein kinase mTOR (MTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[438]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[439]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[440]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[441]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[442]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[443]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[426]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[444]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[445]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[379]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[446]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[447]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[448]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[449]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[450]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[451]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[452]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[453]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[454]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[401]

Drug(s) Affected By Neuropeptide Y receptor type 2 (NPY2R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[183]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[104]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[66]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[66]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[209]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[66]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[455]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[64]

Drug(s) Affected By Tuberin (TSC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[180]
Selenium	DM25CGV	N. A.	N. A.	Approved	[213]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[76]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[456]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[141]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[457]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[458]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[459]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[61]

Drug(s) Affected By Glycogen synthase kinase-3 alpha (GSK3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[213]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[460]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[461]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[462]
Tacrolimus	DMZ7XNQ	Graft-versus-host disease	4B24	Approved	[461]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[130]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[463]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[460]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[213]
Adaphostin	DM16QSG	Chronic myelogenous leukaemia	2A20.0	Phase 1	[464]

Drug(s) Affected By Glycogen synthase kinase-3 beta (GSK3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[348]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[465]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[466]
Selenium	DM25CGV	N. A.	N. A.	Approved	[213]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[467]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[352]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[122]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[468]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[148]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[287]

Drug(s) Affected By BH3-interacting domain death agonist (BID)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[262]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[113]
Selenium	DM25CGV	N. A.	N. A.	Approved	[469]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[122]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[230]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[470]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[471]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[367]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]

Drug(s) Affected By Cyclin-dependent kinase 5 (CDK5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[472]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[352]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[473]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[188]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[145]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[140]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[141]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[474]

Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[262]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[347]
Selenium	DM25CGV	N. A.	N. A.	Approved	[213]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[475]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[388]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[406]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[476]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[178]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[477]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[341]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[401]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[88]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[345]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[80]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[478]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[479]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[180]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[480]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[337]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[481]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[482]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[113]
Selenium	DM25CGV	N. A.	N. A.	Approved	[213]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[483]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[484]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[485]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[486]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[122]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[92]

Drug(s) Affected By Beclin-1 (BECN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[487]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[88]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[442]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[484]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[488]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[489]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[490]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[491]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[492]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[493]

Drug(s) Affected By Bcl-2 homologous antagonist/killer (BAK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[494]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[180]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[495]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[484]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[496]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Levamisole	DM5EN79	Parasitic infection	1D0Y-1G2Z	Approved	[497]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[498]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[499]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[500]

Drug(s) Affected By Inactive caspase-12 (CASP12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[501]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[502]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[503]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[504]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[505]
Thymoquinone	DMVDTR2	Polycystic ovarian syndrome	5A80.1	Phase 2/3	[506]
Tetrandrine	DMAOJBX	Sarcoma	2A60-2C35	Phase 1	[507]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[64]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[502]
3,7,3',4'-TETRAHYDROXYFLAVONE	DMES906	Discovery agent	N.A.	Investigative	[508]

Drug(s) Affected By Bcl-2-binding component 3, isoforms 3/4 (BBC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[113]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[115]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[509]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[510]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[121]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[511]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[512]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[513]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[274]

Drug(s) Affected By Tribbles homolog 3 (TRIB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[253]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[150]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[187]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[514]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[93]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[310]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[514]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[215]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[515]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[138]

Drug(s) Affected By 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (PLCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[234]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[59]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[516]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[101]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[517]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[518]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[62]

Drug(s) Affected By Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[281]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[282]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[284]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[284]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[519]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[284]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[286]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[287]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[375]

Drug(s) Affected By Long-chain-fatty-acid--CoA ligase 6 (ACSL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[76]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[230]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[171]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[520]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[101]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[50]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[130]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[521]
methyl p-hydroxybenzoate	DMO58UW	Discovery agent	N.A.	Investigative	[522]

Drug(s) Affected By Mu-type opioid receptor (OPRM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Alvimopan	DMHR8KW	Gastrointestinal disease	DE2Z	Approved	[523]
Fentanyl	DM8WAHT	Analgesia	MB40.8	Approved	[524]
Morphine	DMRMS0L	Advanced cancer	2A00-2F9Z	Approved	[525]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[183]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[526]
Butorphanol	DM5KYPJ	Pain	MG30-MG3Z	Approved	[527]
Oliceridine	DM6MDCF	Acute pain	MG31	Approved	[524]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[528]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[529]

Drug(s) Affected By Flavin-containing monooxygenase 3 (FMO3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[59]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[62]
Perazine	DM2AOTZ	Psychotic disorder	6A20-6A25	Approved	[530]
Almogran	DM7I64Z	Migraine	8A80	Approved	[531]
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[532]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[533]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[534]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[535]

Drug(s) Affected By 3',5'-cyclic-AMP phosphodiesterase 4D (PDE4D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[148]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[66]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[235]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[140]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[141]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[59]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[101]

Drug(s) Affected By Coiled-coil alpha-helical rod protein 1 (CCHCR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[213]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[354]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[126]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[239]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[60]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[242]

Drug(s) Affected By 5-hydroxytryptamine receptor 1A (HTR1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Trazodone	DMK1GBJ	Depression	6A70-6A7Z	Approved	[536]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[536]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[537]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[538]
Perospirone	DMVHJLX	Psychotic disorder	6A20-6A25	Approved	[538]
Etoperidone	DMR7U8F	N. A.	N. A.	Phase 4	[536]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[539]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[64]
DU 125530	DM63UA9	Mood disorder	6A60-6E23	Discontinued in Phase 2	[540]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[539]

Drug(s) Affected By Sodium-dependent dopamine transporter (SLC6A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[541]
Amphetamine	DMSZQAK	Attention deficit hyperactivity disorder	6A05.Z	Approved	[542]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[543]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[544]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[108]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Dextroamphetamine	DMMIHVP	Attention deficit hyperactivity disorder	6A05.Z	Approved	[545]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[210]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[546]

Drug(s) Affected By Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 (LINGO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[66]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[59]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[64]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[65]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[69]

Drug(s) Affected By Prokineticin receptor 2 (PROKR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[432]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[64]

Drug(s) Affected By Rap guanine nucleotide exchange factor 5 (RAPGEF5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[190]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[46]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[140]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[547]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[101]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[50]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[242]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[548]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[210]

Drug(s) Affected By Cubilin (CUBN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[234]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[210]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[549]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[64]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[550]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[551]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[65]

Drug(s) Affected By Neuropeptide Y receptor type 1 (NPY1R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[104]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[66]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[268]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[140]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[96]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[552]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[553]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[64]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[554]

Drug(s) Affected By Regulator of G-protein signaling 17 (RGS17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[104]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[215]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[108]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[59]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[555]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[61]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[555]

Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 5 (MAP2K5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[180]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[148]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[556]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[140]
Hesperidin	DMI5DW1	Vascular purpura	3B60	Approved	[557]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[323]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[558]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[242]

Drug(s) Affected By RNA-binding protein Raly (RALY)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[213]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[217]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[157]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[238]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[141]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[59]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[101]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[62]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[63]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[130]

Drug(s) Affected By Collagen alpha-1(XXVIII) chain (COL28A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[62]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[242]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[559]

Drug(s) Affected By FK506-binding protein 15 (FKBP15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[148]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[171]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[141]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[63]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[217]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[217]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[65]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[126]
Hexadecanoic acid	DMWUXDZ	Discovery agent	N.A.	Investigative	[560]

Drug(s) Affected By Mitochondrial amidoxime reducing component 2 (MTARC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[148]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[66]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[268]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[561]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[562]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[66]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[563]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[564]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[565]

Drug(s) Affected By 5-hydroxytryptamine receptor 6 (HTR6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[566]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[566]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[64]
LYSERGIC ACID DIETHYLAMIDE	DMACMLO	Addictive disorder	6C50-6C5Z	Withdrawn from market	[567]
SB 258585	DM2QJKZ	Discovery agent	N.A.	Investigative	[568]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[126]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[569]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[570]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[481]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[347]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[571]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[572]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[573]
Selenium	DM25CGV	N. A.	N. A.	Approved	[213]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[574]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[443]

Drug(s) Affected By PR domain zinc finger protein 2 (PRDM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[575]
Selenium	DM25CGV	N. A.	N. A.	Approved	[213]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[183]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[178]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[140]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[100]
Bortezomib	DMNO38U	Leukemia		Approved	[231]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[101]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[576]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[577]

Drug(s) Affected By Histone-lysine N-methyltransferase SMYD3 (SMYD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[65]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[104]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[188]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[141]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[59]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[223]

Drug(s) Affected By Beta-arrestin-2 (ARRB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[268]
Fentanyl	DM8WAHT	Analgesia	MB40.8	Approved	[578]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[141]
Isoproterenol	DMK7MEY	Atrioventricular block		Approved	[579]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[60]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[62]
Morphine	DMRMS0L	Advanced cancer	2A00-2F9Z	Approved	[580]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[581]

Drug(s) Affected By D(4) dopamine receptor (DRD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[582]
Haloperidol	DM96SE0	Delirium		Approved	[389]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[259]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[59]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[241]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[583]
Droperidol	DM0DXA8	Nausea	MD90	Approved	[51]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[51]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[51]

Drug(s) Affected By Unconventional myosin-Vb (MYO5B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[108]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[108]
Haloperidol	DM96SE0	Delirium		Approved	[170]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[241]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[584]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[63]

Drug(s) Affected By Cadherin-13 (CDH13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[159]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[59]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[585]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[50]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[63]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[209]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[586]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[587]

Drug(s) Affected By Metabotropic glutamate receptor 2 (GRM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[100]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[61]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[161]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[238]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[209]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[210]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[588]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[64]

Drug(s) Affected By POU domain, class 5, transcription factor 1 (POU5F1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[589]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[590]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[591]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[66]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[592]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[593]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[594]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[595]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[596]

Drug(s) Affected By Transient receptor potential cation channel subfamily M member 3 (TRPM3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[104]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[105]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[597]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[140]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[518]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[62]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[66]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[238]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[66]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[64]

Drug(s) Affected By Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' (PDE6C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[242]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[161]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[598]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[64]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[126]

Drug(s) Affected By Proenkephalin-B (PDYN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[180]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[66]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[140]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[599]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[600]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[100]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[223]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[223]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[601]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[50]

Drug(s) Affected By Astrotactin-2 (ASTN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[66]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[115]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[354]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[101]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[223]

Drug(s) Affected By Dendritic cell-specific transmembrane protein (DCSTAMP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[148]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[260]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[518]
ANW-32821	DMMJOZD	N. A.	N. A.	Phase 2	[602]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[549]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[603]
PMID27336223-Compound-5	DM6E50A	N. A.	N. A.	Patented	[260]

Drug(s) Affected By Gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[140]
Flunitrazepam	DMGR5Z3	Insomnia	7A00-7A0Z	Approved	[604]
Flumazenil	DMPCG2L	Benzodiazepine overdose	PC91	Approved	[605]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[606]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[607]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[521]
TBPS	DMFC3XP	Discovery agent	N.A.	Investigative	[608]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[65]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[69]
Manganese	DMKT129	N. A.	N. A.	Investigative	[609]

Drug(s) Affected By Bis(5'-adenosyl)-triphosphatase (FHIT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[354]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[250]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[610]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[241]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[61]
Hydralazine	DMU8JGH	Chronic heart failure	BD1Z	Approved	[611]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[612]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[613]

Drug(s) Affected By Prostaglandin G/H synthase 1 (PTGS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[614]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[250]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[195]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[615]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[92]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[511]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[156]
Bupivacaine	DM4PRFC	Anaesthesia	9A78.6	Approved	[616]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[156]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[66]

Drug(s) Affected By Cytochrome P450 2E1 (CYP2E1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fomepizole	DM6VOWQ	Athylene glycol or methanol poisoning	NE61	Approved	[617]
Ademetionine	DMYQDBO	Hepatic fibrosis	DB93.0	Approved	[618]
Theophylline	DMRJFN9	Bronchitis	CA20	Approved	[51]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[619]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[620]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[62]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[621]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Didanosine	DMI2QPE	Human immunodeficiency virus infection	1C62	Approved	[51]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[622]

Drug(s) Affected By Sodium- and chloride-dependent glycine transporter 1 (SLC6A9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[623]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[153]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[166]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[96]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[96]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[96]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[96]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[96]

Drug(s) Affected By CUB and sushi domain-containing protein 1 (CSMD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[65]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[624]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[64]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[65]

Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[350]
Selenium	DM25CGV	N. A.	N. A.	Approved	[182]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[184]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[625]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[85]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[626]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[627]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[230]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[628]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[218]

Drug(s) Affected By E3 ubiquitin-protein ligase SH3RF3 (SH3RF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[104]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[138]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[140]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[62]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[63]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[238]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[209]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[549]

Drug(s) Affected By Estrogen receptor (ESR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[629]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[630]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[631]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[632]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[633]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[634]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[635]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[636]
Procaine	DM4LSNE	Anaesthesia	9A78.6	Approved	[632]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[637]

Drug(s) Affected By Brain-derived neurotrophic factor (BDNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Haloperidol	DM96SE0	Delirium		Approved	[638]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[198]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[639]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[104]
Bupivacaine	DM4PRFC	Anaesthesia	9A78.6	Approved	[640]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[641]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[138]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[398]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[171]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]

Drug(s) Affected By Cytochrome P450 1A2 (CYP1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zolmitriptan	DM1IB4Q	Migraine	8A80	Approved	[642]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[642]
Etoricoxib	DM6A4NW	Rheumatoid arthritis	FA20	Approved	[642]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[643]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[644]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[645]
Nifedipine	DMSVOZT	Angina pectoris	BA40	Approved	[646]
Zileuton	DMVRIC2	Allergic asthma	CA23.0	Approved	[647]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[648]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[51]

Drug(s) Affected By Glutathione S-transferase P (GSTP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[649]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[241]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[650]
Chlorambucil	DMRKE63	Chronic lymphocytic leukaemia	2A82.0	Approved	[650]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[651]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[623]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[180]
Selenium	DM25CGV	N. A.	N. A.	Approved	[213]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[356]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[652]

Drug(s) Affected By Mitochondrial amidoxime-reducing component 1 (MTARC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[237]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[148]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[140]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[399]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[240]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[101]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[237]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[562]

Drug(s) Affected By Heparan sulfate glucosamine 3-O-sulfotransferase 4 (HS3ST4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[238]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[548]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[64]

Drug(s) Affected By 3',5'-cyclic-AMP phosphodiesterase 4B (PDE4B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[653]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[215]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[654]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[398]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[140]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[126]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[234]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[259]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[655]

Drug(s) Affected By Acyloxyacyl hydrolase (AOAH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[140]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[61]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[66]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[224]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[64]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[69]

Drug(s) Affected By cGMP-dependent protein kinase 1 (PRKG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[354]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[140]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[63]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[210]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[209]
EXISULIND	DMBY56U	Colorectal cancer	2B91.Z	Phase 3	[656]
CP-461	DMEYMTX	Inflammatory bowel disease	DD72	Phase 2	[656]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[64]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[190]
(5-(1-benzyl-1H-indazol-3-yl)furan-2-yl)methanol	DM15P2G	Discovery agent	N.A.	Investigative	[656]

Drug(s) Affected By Alpha-synuclein (SNCA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[104]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[105]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[354]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[561]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[141]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[259]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[59]
Bortezomib	DMNO38U	Leukemia		Approved	[657]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[658]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[223]

Drug(s) Affected By Catechol O-methyltransferase (COMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[659]
Dobutamine	DMD1B8Z	Heart failure	BD10-BD13	Approved	[659]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[659]
Modafinil	DMYILBE	Malignant glioma	2A00.0	Approved	[660]
Levodopa	DMN3E57	Parkinson disease	8A00.0	Approved	[659]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[198]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[180]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[104]
Tolcapone	DM8MNVO	Parkinson disease	8A00.0	Approved	[661]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]

Drug(s) Affected By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[662]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[663]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[664]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[665]
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[666]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[666]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[667]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[668]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[669]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[670]

Drug(s) Affected By Glutathione S-transferase theta-1 (GSTT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[671]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[230]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[105]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[140]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[323]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[62]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[672]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[673]

Drug(s) Affected By Glutathione S-transferase Mu 1 (GSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[649]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[674]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[675]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[676]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[156]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[156]
Methyldopa	DM5I621	Hypertension	BA00-BA04	Approved	[677]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[105]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[108]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[108]

Drug(s) Affected By Procollagen C-endopeptidase enhancer 2 (PCOLCE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[66]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[190]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[678]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[234]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[59]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[399]

Drug(s) Affected By Adenylate kinase isoenzyme 5 (AK5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[353]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[140]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[141]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[234]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[226]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[101]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[558]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[679]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[680]

Drug(s) Affected By PH and SEC7 domain-containing protein 3 (PSD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[126]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[681]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[682]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[101]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[249]

Drug(s) Affected By Plasma serine protease inhibitor (SERPINA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[353]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[250]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[683]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[59]
ARZOXIFENE	DMOKCVI	Breast cancer	2C60-2C65	Approved	[684]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[101]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[518]

Drug(s) Affected By Xylosyl- and glucuronyltransferase LARGE1 (LARGE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[140]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[59]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[142]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[63]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[130]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[603]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[550]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[65]

Drug(s) Affected By Adenosine receptor A2a (ADORA2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[685]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[148]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[184]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[235]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Adenosine	DMM2NSK	Paroxysmal supraventricular tachycardia	BC81.Z	Approved	[686]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[184]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[184]

Drug(s) Affected By Complement decay-accelerating factor (CD55)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[262]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[687]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[218]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[66]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[445]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[688]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[268]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[46]

Drug(s) Affected By Pro-neuregulin-1, membrane-bound isoform (NRG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[120]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[65]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[484]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[104]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[689]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[66]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adrenergic receptor alpha-1B (ADRA1B)	TTBRKXS	ADA1B_HUMAN	Antagonist	[4]
Dopamine D2 receptor (D2R)	TTEX248	DRD2_HUMAN	Agonist	[3]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Vesicular amine transporter 2 (SLC18A2)	DTT7VPB	VMAT2_HUMAN	Substrate	[5]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 2D6 (CYP2D6) Main DME	DECB0K3	CP2D6_HUMAN	Substrate	[6]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (PLCB1)	OT9HYT7A	PLCB1_HUMAN	Gene/Protein Processing	[7]
2-oxoglutarate dehydrogenase-like, mitochondrial (OGDHL)	OT1AZK6R	OGDHL_HUMAN	Gene/Protein Processing	[8]
3',5'-cyclic-AMP phosphodiesterase 4B (PDE4B)	OTOA8WU2	PDE4B_HUMAN	Drug Response	[9]
3',5'-cyclic-AMP phosphodiesterase 4D (PDE4D)	OT1RWFV0	PDE4D_HUMAN	Drug Response	[9]
5-hydroxytryptamine receptor 1A (HTR1A)	OT38K9MK	5HT1A_HUMAN	Drug Response	[10]
5-hydroxytryptamine receptor 6 (HTR6)	OT8GTDDY	5HT6R_HUMAN	Drug Response	[11]
Abnormal spindle-like microcephaly-associated protein (ASPM)	OTKXQMNA	ASPM_HUMAN	Gene/Protein Processing	[8]
Actin, alpha cardiac muscle 1 (ACTC1)	OTJU04B1	ACTC_HUMAN	Gene/Protein Processing	[8]
Activator of apoptosis harakiri (HRK)	OTR4GWJ0	HRK_HUMAN	Gene/Protein Processing	[8]
Acyloxyacyl hydrolase (AOAH)	OTOYBXKW	AOAH_HUMAN	Drug Response	[9]

References

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