Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMPM4SK)

• Drug Name: Methamphetamine Drug Info
• Synonyms: METHAMPHETAMINE; Metamfetamine; d-Deoxyephedrine; d-Desoxyephedrine; d-Methamphetamine; d-N-Methylamphetamine; Metamphetamine; L-Methamphetamine; d-Methylamphetamine; Methylamphetamine; d-Phenylisopropylmethylamine; N-Methylamphetamine; (S)-Methamphetamine; Norodin; (+)-Methylamphetamine; d-(S)-Methamphetamine; D-1-Phenyl-2-methylaminopropane; Metamfetaminum; Desyphed; (+)-N-Methylamphetamine; (S)-Methylamphetamine; (+)-(S)-Deoxyephedrine; Methyl-beta-phenylisopropylamine; 1-Phenyl-2-methylaminopropane; (S)-(+)-Deoxyephedrine; Crank; Desohyephedrine; Metamfetamina; Meth; Methamphetaminum; Speed; Stimulex; Crank [Street Name]; Crystal Meth; Crystal Meth [Street Name]; Desyphed hydrochloride; ICE [Street Name]; Metamfetamine [INN];Metamfetaminum [Latin]; Metanfetamina [Spanish]; Methamphetaminum [JP]; Speed [Street Name]; D-Deoxyephedrine; D-Desoxyephedrine; D-Methamphetamine; D-Methylamphetamine; D-Phenylisopropylmethylamine;Desoxyn (TN); Metamfetamina [INN-Spanish]; Metamfetamine (INN); Metamfetamine-m; Metamfetaminum [INN-Latin]; Metanfetamina [INN-Spanish]; Meth (Street Name); Methamphetaminum [INN-Latin]; D-N-Methylamphetamine; D-(S)-Methamphetamine; D-N,alpha-dimethylphenethylamine; Methamphetamine, its salts, isomers, and salts of its isomers; N-Methyl-beta-phenylisopropylamin; N-Methyl-beta-phenylisopropylamin [German]; N-Methyl-beta-phenylisopropylamine; D-1-Phenyl-2-methylaminopropan; D-1-Phenyl-2-methylaminopropan [German]; S-(+)-Methamphetamine; D-N,alpha-Dimethylphenethylamine; N-Methyl-1-phenyl-2-propanamine; Benzeneethanamine, N,alpha-dimethyl-, (S)-(9CI); Benzeneethanamine, N,alpha-dimethyl-, (alphaS)-(9CI); Phenethylamine, N,alpha-dimethyl-, (S)-(+)-(8CI); (+)-(S)-N-alpha-Dimethylphenethylamine; (+)-2-(N-Methylamino)-1-phenylpropane; (+)-N,alpha-Dimethyl-beta-phenylethylamine; (+)-N,alpha-Dimethylphenethylamine; (+)-methamphetamine; (2S)-N-methyl-1-phenylpropan-2-amine; (S)-(+)-Methamphetamine; (S)-(+)-N,alpha,dimethylphenethylamine; (S)-N,alpha-Dimethylbenzeneethanamine; (S)-N,alpha-Dimethylbenzeneethanoamine; (alphaS)-N,alpha-dimethylbenzeneethanamine; 1-Phenyl-2-methylamino-propan; 1-Phenyl-2-methylamino-propan [German]; 2S-(+)-Methamphetamine; Methamfetamine

Indication

Disease Entry	ICD 11	Status	REF
Anxiety		Approved	[1]
Attention deficit hyperactivity disorder	6A05.Z	Approved	[2]
Depression	6A70-6A7Z	Approved	[1]
Methamphetamine dependence	6C46.2	Approved	[1]
Obesity	5B81	Approved	[1]
Pain	MG30-MG3Z	Approved	[3]
Sexually transmitted infection	1A9Z	Approved	[1]
Substance dependence		Approved	[1]

• Therapeutic Class: Central Nervous System Stimulants
• Cross-matching ID:
  PubChem CID: 10836
  ChEBI ID: CHEMBL1201201
  CAS Number: CAS 537-46-2
  TTD Drug ID: DMPM4SK
  VARIDT Drug ID: DR00256
  INTEDE Drug ID: DR1036
  ACDINA Drug ID: D00207

Molecule-Related Drug Atlas

Drug(s) Targeting Adrenergic receptor alpha-1B (ADRA1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Propericiazine	DME9JNL	Psychiatric disorder	6E8Z	Approved	[12]
Methoxamine	DMF5XQH	Hypertension	BA00-BA04	Approved	[13]
Phendimetrazine	DM6TS1N	Obesity	5B81	Approved	[14]
MEDETOMIDINE	DMX9Y7V	Pain	MG30-MG3Z	Phase 2	[15]
TIOSPIRONE	DME5QDP	N. A.	N. A.	Discontinued in Phase 3	[16]
Sunepitron	DM6M8ZX	N. A.	N. A.	Discontinued in Phase 3	[17]
MAZAPERTINE	DMRHYAU	N. A.	N. A.	Discontinued in Phase 2	[18]
SOU-001	DMPAEK5	Urinary incontinence	MF50.2	Discontinued in Phase 2	[19]
SNAP-5089	DMROJEN	Heart arrhythmia	BC65	Terminated	[20]
WB-4101	DMQU8B1	N. A.	N. A.	Terminated	[21]

Drug(s) Targeting Dopamine D2 receptor (D2R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[22]
Haloperidol	DM96SE0	Delirium		Approved	[23]
Perphenazine	DMA4MRX	Schizophrenia	6A20	Approved	[24]
Perazine	DM2AOTZ	Psychotic disorder	6A20-6A25	Approved	[25]
Domperidone	DMBDPY0	Gastrointestinal disease	DE2Z	Approved	[26]
Levodopa	DMN3E57	Parkinson disease	8A00.0	Approved	[27]
Quetiapine	DM1N62C	Anorexia nervosa cachexia	6B80	Approved	[28]
Pimozide	DMW83TP	Schizophrenia	6A20	Approved	[29]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[30]
Iloperidone	DM6AUFY	Schizophrenia	6A20	Approved	[31]

Drug(s) Transported By Vesicular amine transporter 2 (SLC18A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[32]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[33]
Norepinephrine	DMOUC09	Alopecia	ED70	Approved	[32]
SEROTONIN	DMOFCRY	Discovery agent	N.A.	Investigative	[32]

Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[34]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[35]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[36]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[37]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[38]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[39]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[40]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[41]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[42]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[43]

Drug(s) Affected By D(2) dopamine receptor (DRD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Droperidol	DM0DXA8	Nausea	MD90	Approved	[44]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[44]
Zuclopenthixol	DMKYD5N	Schizophrenia	6A20	Approved	[44]
Meglitinides	DM1OFHN	Type-2 diabetes	5A11	Approved	[45]
Sulpiride	DMF54ZG	Schizophrenia	6A20	Approved	[46]
Risperidone	DMN6DXL	Bipolar I disorder		Approved	[47]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[48]
Bromocriptine	DMVE3TK	Acromegaly	5A60.0	Approved	[49]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[50]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[51]

Drug(s) Affected By PRKCA-binding protein (PICK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[52]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[53]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[54]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[55]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[56]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[57]

Drug(s) Affected By Zeta-sarcoglycan (SGCZ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[58]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[57]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[58]

Drug(s) Affected By Cytosolic carboxypeptidase 4 (AGBL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[60]
Chlorothiazide	DMLHESP	Chronic heart failure	BD1Z	Approved	[61]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[62]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[58]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[63]

Drug(s) Affected By Activator of apoptosis harakiri (HRK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[64]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[65]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[66]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[67]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[64]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[68]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[69]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[70]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[71]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[72]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[73]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[74]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[75]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[76]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[77]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[78]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[79]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[80]

Drug(s) Affected By Cell division control protein 45 homolog (CDC45)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[81]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[82]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[85]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[86]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[87]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[87]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[67]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[88]

Drug(s) Affected By BAI1-associated protein 3 (BAIAP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[89]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[90]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[91]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[57]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[58]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[92]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[93]

Drug(s) Affected By G2/mitotic-specific cyclin-B2 (CCNB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[81]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[71]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[94]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[95]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[96]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[97]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[98]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[99]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[87]

Drug(s) Affected By Kinesin-like protein KIF20A (KIF20A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[100]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[94]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[101]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[95]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[96]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[87]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[87]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[66]

Drug(s) Affected By ATP-binding cassette sub-family C member 6 (ABCC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzbromarone	DMC3YUA	Gout	FA25	Approved	[103]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[103]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[96]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[104]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[106]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[107]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[108]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]

Drug(s) Affected By Keratin, type I cytoskeletal 14 (KRT14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[111]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[112]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[113]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[114]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[115]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[111]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[116]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[117]

Drug(s) Affected By Fatty acid-binding protein, heart (FABP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[118]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[119]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Haloperidol	DM96SE0	Delirium		Approved	[120]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[123]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[120]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[124]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[125]

Drug(s) Affected By Galanin peptides (GAL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[126]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[94]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[126]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[127]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[128]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[129]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[87]
Methazolamide	DM7J2TA	Glaucoma/ocular hypertension	9C61	Approved	[126]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[87]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]

Drug(s) Affected By Phospholipase A2 group V (PLA2G5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[130]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[131]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[132]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[56]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[131]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[57]
SB-203347	DM3AWMF	Discovery agent	N.A.	Investigative	[133]
Beta-D-Glucose	DM5IHYP	Discovery agent	N.A.	Investigative	[134]
fMet-Leu-Phe	DMQ391A	N. A.	N. A.	Investigative	[134]

Drug(s) Affected By DNA-binding protein inhibitor ID-1 (ID1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[135]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[136]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Selenium	DM25CGV	N. A.	N. A.	Approved	[138]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[85]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[139]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[140]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[141]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[66]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]

Drug(s) Affected By Actin, alpha cardiac muscle 1 (ACTC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[142]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[143]
Estriol	DMOEM2I	Hormone deficiency	5A61.1	Approved	[144]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[70]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[144]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[145]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[56]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[89]

Drug(s) Affected By Origin recognition complex subunit 1 (ORC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[146]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[96]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[147]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[98]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[87]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[87]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[88]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[149]

Drug(s) Affected By PCNA-associated factor (PCLAF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[100]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[95]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[150]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[129]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[87]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[87]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[151]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[114]

Drug(s) Affected By Disks large-associated protein 5 (DLGAP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[152]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[95]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[96]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[87]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[87]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[66]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[123]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[123]

Drug(s) Affected By Centrosomal protein of 55 kDa (CEP55)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[153]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[154]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[87]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[155]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[151]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[156]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[157]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[158]

Drug(s) Affected By Solute carrier organic anion transporter family member 4C1 (SLCO4C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[147]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[128]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[107]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[88]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[157]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[158]

Drug(s) Affected By Protein MCM10 homolog (MCM10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[81]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[94]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[101]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[159]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[87]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[87]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[155]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[151]

Drug(s) Affected By Ras guanyl-releasing protein 3 (RASGRP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[160]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[54]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[161]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[56]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[57]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[162]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[163]

Drug(s) Affected By Abnormal spindle-like microcephaly-associated protein (ASPM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[95]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[96]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[154]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[164]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[87]
Riboflavin	DM8YMWE	Acne vulgaris	ED80	Approved	[165]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[87]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[66]

Drug(s) Affected By CD177 antigen (CD177)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[154]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[57]

Drug(s) Affected By Holliday junction recognition protein (HJURP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[159]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[167]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[87]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[87]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[151]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[143]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[168]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[54]

Drug(s) Affected By Interferon-stimulated gene 20 kDa protein (ISG20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[169]
Aripiprazole	DM3NUMH	Bipolar I disorder		Approved	[170]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[169]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[87]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[87]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[104]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[52]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[169]

Drug(s) Affected By RAD51-associated protein 1 (RAD51AP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[171]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[96]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[87]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[87]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[172]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[151]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[158]

Drug(s) Affected By Lymphokine-activated killer T-cell-originated protein kinase (PBK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[95]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[96]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[173]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[87]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[87]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[66]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]

Drug(s) Affected By Kinesin-like protein KIFC1 (KIFC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[130]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[95]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[87]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[87]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[66]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[151]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[114]

Drug(s) Affected By Denticleless protein homolog (DTL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[174]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[87]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[87]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[88]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[175]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[143]

Drug(s) Affected By Adherens junction-associated protein 1 (AJAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[176]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[153]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[177]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[60]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[117]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[60]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[57]
PMID27336223-Compound-5	DM6E50A	N. A.	N. A.	Patented	[177]

Drug(s) Affected By 2-oxoglutarate dehydrogenase-like, mitochondrial (OGDHL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[114]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[157]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[70]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[94]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[55]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[56]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[60]

Drug(s) Affected By Bcl-2-like protein 11 (BCL2L11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[179]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[180]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[181]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[182]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[183]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[184]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[185]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[186]

Drug(s) Affected By E3 ubiquitin-protein ligase parkin (PRKN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Emtricitabine	DMBMUWZ	Hepatitis virus infection	1E50-1E51	Approved	[187]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[188]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[189]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[190]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[191]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[192]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[54]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[56]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[188]

Drug(s) Affected By Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[193]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[194]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[195]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[196]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[197]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[196]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[153]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[198]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[199]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[196]

Drug(s) Affected By T-cell surface glycoprotein CD3 delta chain (CD3D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[128]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[173]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[70]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[200]
Nabiximols	DMHKJ5I	Cancer related pain	MG30	Phase 3	[201]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[202]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[109]

Drug(s) Affected By Amyloid-beta precursor protein (APP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Selenium	DM25CGV	N. A.	N. A.	Approved	[138]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[203]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[204]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[84]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[205]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[207]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[154]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[208]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[209]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[210]
Fructose	DM43AN2	Vomiting	MD90	Approved	[44]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[211]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[212]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[194]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[213]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[214]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[215]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[216]

Drug(s) Affected By Synaptophysin (SYP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[217]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[218]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[217]
Abacavir	DMMN36E	Human immunodeficiency virus infection	1C62	Approved	[219]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[160]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[55]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[90]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[146]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[220]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[221]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[74]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[222]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[223]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[222]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[224]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[225]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[226]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-4 (ATF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[194]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[227]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Selenium	DM25CGV	N. A.	N. A.	Approved	[138]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[76]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[198]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[199]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[228]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[229]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[230]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-6 alpha (ATF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[196]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[181]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[196]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[147]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[198]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[231]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[228]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[196]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[232]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[233]

Drug(s) Affected By Troponin I, cardiac muscle (TNNI3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[153]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[234]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[76]
Perphenazine	DMA4MRX	Schizophrenia	6A20	Approved	[235]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[236]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[237]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[160]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[238]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[55]

Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[239]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[240]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[194]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[241]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[242]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[243]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[244]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[245]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]

Drug(s) Affected By D(1A) dopamine receptor (DRD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[44]
Haloperidol	DM96SE0	Delirium		Approved	[246]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[247]
Pergolide mesylate	DM5GKOV	N. A.	N. A.	Approved	[248]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[246]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[249]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[250]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[251]
Bardoxolone methyl	DMODA2X	Mixed connective tissue disease	4A43.3	Phase 3	[252]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fructose	DM43AN2	Vomiting	MD90	Approved	[253]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[254]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[255]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[140]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[256]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[88]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[257]
Mirtazapine	DML53ZJ	Depression	6A70-6A7Z	Approved	[258]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[53]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[259]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[260]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[261]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[262]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[263]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[264]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[265]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[266]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[267]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[268]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[269]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[260]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[270]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[271]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[272]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[259]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[44]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[273]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[262]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[263]

Drug(s) Affected By Sodium-dependent serotonin transporter (SLC6A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paroxetine	DM5PVQE	Anxiety disorder	6B00-6B0Z	Approved	[274]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[275]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[94]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[276]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[277]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[278]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[96]
Aripiprazole	DM3NUMH	Bipolar I disorder		Approved	[279]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[277]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[67]

Drug(s) Affected By D(3) dopamine receptor (DRD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Haloperidol	DM96SE0	Delirium		Approved	[280]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[281]
Risperidone	DMN6DXL	Bipolar I disorder		Approved	[282]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[283]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[284]
Droperidol	DM0DXA8	Nausea	MD90	Approved	[44]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[44]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[44]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[44]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[44]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[285]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[286]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[194]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[227]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[196]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[287]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[288]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[289]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[95]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[96]

Drug(s) Affected By Tuberin (TSC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Selenium	DM25CGV	N. A.	N. A.	Approved	[138]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[203]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[290]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[114]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[291]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[292]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[293]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[54]

Drug(s) Affected By BH3-interacting domain death agonist (BID)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[273]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[74]
Selenium	DM25CGV	N. A.	N. A.	Approved	[294]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[295]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[153]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[296]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[297]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[298]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]

Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[273]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[299]
Selenium	DM25CGV	N. A.	N. A.	Approved	[138]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[300]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[245]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[301]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[96]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[302]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[254]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[303]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[304]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[305]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[74]
Selenium	DM25CGV	N. A.	N. A.	Approved	[138]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[306]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[307]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[308]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[309]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[310]

Drug(s) Affected By Bcl-2 homologous antagonist/killer (BAK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[311]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[312]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[307]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[313]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[153]
Levamisole	DM5EN79	Parasitic infection	1D0Y-1G2Z	Approved	[314]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[315]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[316]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[317]

Drug(s) Affected By Inactive caspase-12 (CASP12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[318]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[319]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[320]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[321]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[322]
Thymoquinone	DMVDTR2	Polycystic ovarian syndrome	5A80.1	Phase 2/3	[323]
Tetrandrine	DMAOJBX	Sarcoma	2A60-2C35	Phase 1	[324]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[57]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[319]
3,7,3',4'-TETRAHYDROXYFLAVONE	DMES906	Discovery agent	N.A.	Investigative	[325]

Drug(s) Affected By Bcl-2-binding component 3, isoforms 3/4 (BBC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[94]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[74]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[76]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[326]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[327]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[82]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[328]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[329]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[330]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[185]

Drug(s) Affected By Tribbles homolog 3 (TRIB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[285]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[104]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[127]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[331]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[64]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[207]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[331]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[140]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[332]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[141]

Drug(s) Affected By 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (PLCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[153]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[157]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[52]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[333]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[70]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[334]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[335]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[55]

Drug(s) Affected By Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[193]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[194]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[196]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[94]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[196]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[336]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[196]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[198]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[199]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[229]

Drug(s) Affected By Long-chain-fatty-acid--CoA ligase 6 (ACSL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[203]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[96]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[295]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[337]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[70]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[338]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[90]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[339]
methyl p-hydroxybenzoate	DMO58UW	Discovery agent	N.A.	Investigative	[340]

Drug(s) Affected By Mu-type opioid receptor (OPRM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Alvimopan	DMHR8KW	Gastrointestinal disease	DE2Z	Approved	[341]
Fentanyl	DM8WAHT	Analgesia	MB40.8	Approved	[342]
Morphine	DMRMS0L	Advanced cancer	2A00-2F9Z	Approved	[343]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[176]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[344]
Butorphanol	DM5KYPJ	Pain	MG30-MG3Z	Approved	[345]
Oliceridine	DM6MDCF	Acute pain	MG31	Approved	[342]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[346]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[347]

Drug(s) Affected By Flavin-containing monooxygenase 3 (FMO3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[52]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[55]
Perazine	DM2AOTZ	Psychotic disorder	6A20-6A25	Approved	[348]
Almogran	DM7I64Z	Migraine	8A80	Approved	[349]
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[350]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[351]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[352]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[353]

Drug(s) Affected By 3',5'-cyclic-AMP phosphodiesterase 4D (PDE4D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[150]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[354]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[66]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[114]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[52]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[70]

Drug(s) Affected By Coiled-coil alpha-helical rod protein 1 (CCHCR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[138]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[96]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[355]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[88]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[156]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[53]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[54]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[200]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[161]

Drug(s) Affected By 5-hydroxytryptamine receptor 1A (HTR1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Trazodone	DMK1GBJ	Depression	6A70-6A7Z	Approved	[356]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[356]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[357]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[358]
Perospirone	DMVHJLX	Psychotic disorder	6A20-6A25	Approved	[358]
Etoperidone	DMR7U8F	N. A.	N. A.	Phase 4	[356]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[359]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[57]
DU 125530	DM63UA9	Mood disorder	6A60-6E23	Discontinued in Phase 2	[360]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[359]

Drug(s) Affected By Sodium-dependent dopamine transporter (SLC6A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[361]
Amphetamine	DMSZQAK	Attention deficit hyperactivity disorder	6A05.Z	Approved	[362]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[363]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[364]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[87]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Dextroamphetamine	DMMIHVP	Attention deficit hyperactivity disorder	6A05.Z	Approved	[365]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[366]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[367]

Drug(s) Affected By Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 (LINGO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[153]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[52]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[57]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[58]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[63]

Drug(s) Affected By Rap guanine nucleotide exchange factor 5 (RAPGEF5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[368]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[66]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[369]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[70]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[338]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[161]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[370]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[366]

Drug(s) Affected By Cubilin (CUBN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[157]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[366]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[371]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[57]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[372]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[373]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[58]

Drug(s) Affected By Regulator of G-protein signaling 17 (RGS17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[147]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[140]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[87]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[52]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[374]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[54]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[374]

Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 5 (MAP2K5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[375]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]
Hesperidin	DMI5DW1	Vascular purpura	3B60	Approved	[376]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[377]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[378]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[54]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[200]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[161]

Drug(s) Affected By RNA-binding protein Raly (RALY)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[138]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[379]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[112]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[155]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[114]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[52]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[70]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[55]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[56]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[90]

Drug(s) Affected By Collagen alpha-1(XXVIII) chain (COL28A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[55]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[161]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[380]

Drug(s) Affected By FK506-binding protein 15 (FKBP15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[114]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[56]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[379]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[379]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[58]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[88]
Hexadecanoic acid	DMWUXDZ	Discovery agent	N.A.	Investigative	[381]

Drug(s) Affected By Mitochondrial amidoxime reducing component 2 (MTARC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[186]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[382]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[383]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[60]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[384]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[385]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[386]

Drug(s) Affected By 5-hydroxytryptamine receptor 6 (HTR6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[387]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[387]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[57]
LYSERGIC ACID DIETHYLAMIDE	DMACMLO	Addictive disorder	6C50-6C5Z	Withdrawn from market	[388]
SB 258585	DM2QJKZ	Discovery agent	N.A.	Investigative	[389]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[88]

Drug(s) Affected By PR domain zinc finger protein 2 (PRDM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[390]
Selenium	DM25CGV	N. A.	N. A.	Approved	[138]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[176]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[254]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[69]
Bortezomib	DMNO38U	Leukemia		Approved	[391]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[70]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[392]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[393]

Drug(s) Affected By D(4) dopamine receptor (DRD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[394]
Haloperidol	DM96SE0	Delirium		Approved	[246]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[175]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[52]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[160]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[395]
Droperidol	DM0DXA8	Nausea	MD90	Approved	[44]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[44]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[44]

Drug(s) Affected By Unconventional myosin-Vb (MYO5B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[153]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[354]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[87]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[87]
Haloperidol	DM96SE0	Delirium		Approved	[120]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[67]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[160]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[396]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[56]

Drug(s) Affected By Cadherin-13 (CDH13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[147]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[115]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[52]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[397]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[338]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[56]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[398]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[399]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[400]

Drug(s) Affected By POU domain, class 5, transcription factor 1 (POU5F1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[94]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[401]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[402]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[403]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[404]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[405]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[406]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[407]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[408]

Drug(s) Affected By Transient receptor potential cation channel subfamily M member 3 (TRPM3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[147]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[154]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[409]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[335]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[55]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[60]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[155]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[60]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[57]

Drug(s) Affected By Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' (PDE6C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[161]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[117]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[410]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[57]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[88]

Drug(s) Affected By Proenkephalin-B (PDYN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[411]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[412]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[69]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[237]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[237]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[413]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[338]

Drug(s) Affected By Astrotactin-2 (ASTN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[94]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[153]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[76]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[123]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[67]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[355]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[70]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[237]

Drug(s) Affected By Dendritic cell-specific transmembrane protein (DCSTAMP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[177]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[335]
ANW-32821	DMMJOZD	N. A.	N. A.	Phase 2	[414]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[371]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[415]
PMID27336223-Compound-5	DM6E50A	N. A.	N. A.	Patented	[177]

Drug(s) Affected By Gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]
Flunitrazepam	DMGR5Z3	Insomnia	7A00-7A0Z	Approved	[416]
Flumazenil	DMPCG2L	Benzodiazepine overdose	PC91	Approved	[417]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[418]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[419]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[339]
TBPS	DMFC3XP	Discovery agent	N.A.	Investigative	[420]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[58]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[63]
Manganese	DMKT129	N. A.	N. A.	Investigative	[421]

Drug(s) Affected By Bis(5'-adenosyl)-triphosphatase (FHIT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[153]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[355]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[172]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[422]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[160]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[54]
Hydralazine	DMU8JGH	Chronic heart failure	BD1Z	Approved	[423]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[424]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[425]

Drug(s) Affected By CUB and sushi domain-containing protein 1 (CSMD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[58]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[426]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[57]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[58]

Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[427]
Selenium	DM25CGV	N. A.	N. A.	Approved	[428]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[169]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[429]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[430]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[431]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[432]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[295]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[433]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[159]

Drug(s) Affected By E3 ubiquitin-protein ligase SH3RF3 (SH3RF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[147]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[141]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[54]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[55]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[56]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[155]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[398]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[371]

Drug(s) Affected By Mitochondrial amidoxime-reducing component 1 (MTARC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[152]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[257]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[158]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[70]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[152]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[383]

Drug(s) Affected By Heparan sulfate glucosamine 3-O-sulfotransferase 4 (HS3ST4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[155]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[370]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[57]

Drug(s) Affected By 3',5'-cyclic-AMP phosphodiesterase 4B (PDE4B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[153]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[434]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[140]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[435]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[256]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[88]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[157]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[175]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[436]

Drug(s) Affected By Acyloxyacyl hydrolase (AOAH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[54]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[60]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[437]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[57]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[63]

Drug(s) Affected By cGMP-dependent protein kinase 1 (PRKG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[355]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[56]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[366]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[398]
EXISULIND	DMBY56U	Colorectal cancer	2B91.Z	Phase 3	[438]
CP-461	DMEYMTX	Inflammatory bowel disease	DD72	Phase 2	[438]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[57]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[368]
(5-(1-benzyl-1H-indazol-3-yl)furan-2-yl)methanol	DM15P2G	Discovery agent	N.A.	Investigative	[438]

Drug(s) Affected By Alpha-synuclein (SNCA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[147]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[154]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[355]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[382]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[114]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[175]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[52]
Bortezomib	DMNO38U	Leukemia		Approved	[439]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[440]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[237]

Drug(s) Affected By Procollagen C-endopeptidase enhancer 2 (PCOLCE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[153]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[368]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[67]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[441]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[157]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[52]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[257]

Drug(s) Affected By Adenylate kinase isoenzyme 5 (AK5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[153]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[442]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[114]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[157]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[143]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[70]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[378]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[443]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[444]

Drug(s) Affected By PH and SEC7 domain-containing protein 3 (PSD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[153]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[86]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[67]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[88]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[445]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[446]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[70]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[168]

Drug(s) Affected By Plasma serine protease inhibitor (SERPINA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[94]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[153]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[442]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[172]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[447]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[52]
ARZOXIFENE	DMOKCVI	Breast cancer	2C60-2C65	Approved	[448]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[70]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[335]

Drug(s) Affected By Xylosyl- and glucuronyltransferase LARGE1 (LARGE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[67]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[52]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[94]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[56]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[90]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[415]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[372]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[58]

Drug(s) Affected By Adenosine receptor A2a (ADORA2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[449]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[169]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[150]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[66]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Adenosine	DMM2NSK	Paroxysmal supraventricular tachycardia	BC81.Z	Approved	[450]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[169]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[169]

Drug(s) Affected By Pro-neuregulin-1, membrane-bound isoform (NRG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[81]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[58]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[307]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[147]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[451]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[354]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adrenergic receptor alpha-1B (ADRA1B)	TTBRKXS	ADA1B_HUMAN	Antagonist	[4]
Dopamine D2 receptor (D2R)	TTEX248	DRD2_HUMAN	Agonist	[3]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Vesicular amine transporter 2 (SLC18A2)	DTT7VPB	VMAT2_HUMAN	Substrate	[5]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 2D6 (CYP2D6) Main DME	DECB0K3	CP2D6_HUMAN	Substrate	[6]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (PLCB1)	OT9HYT7A	PLCB1_HUMAN	Gene/Protein Processing	[7]
2-oxoglutarate dehydrogenase-like, mitochondrial (OGDHL)	OT1AZK6R	OGDHL_HUMAN	Gene/Protein Processing	[8]
3',5'-cyclic-AMP phosphodiesterase 4B (PDE4B)	OTOA8WU2	PDE4B_HUMAN	Drug Response	[9]
3',5'-cyclic-AMP phosphodiesterase 4D (PDE4D)	OT1RWFV0	PDE4D_HUMAN	Drug Response	[9]
5-hydroxytryptamine receptor 1A (HTR1A)	OT38K9MK	5HT1A_HUMAN	Drug Response	[10]
5-hydroxytryptamine receptor 6 (HTR6)	OT8GTDDY	5HT6R_HUMAN	Drug Response	[11]
Abnormal spindle-like microcephaly-associated protein (ASPM)	OTKXQMNA	ASPM_HUMAN	Gene/Protein Processing	[8]
Actin, alpha cardiac muscle 1 (ACTC1)	OTJU04B1	ACTC_HUMAN	Gene/Protein Processing	[8]
Activator of apoptosis harakiri (HRK)	OTR4GWJ0	HRK_HUMAN	Gene/Protein Processing	[8]
Acyloxyacyl hydrolase (AOAH)	OTOYBXKW	AOAH_HUMAN	Drug Response	[9]

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