Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMS7TC5)

Drug Name
Geldanamycin Drug Info
Synonyms
GDM; GMY; Geldanamicin; Geldanomycin; Geldaramycin; Antibiotic U 29135; BODIPY-labeled Geldanamycin; Geldanamycin (9CI); Geldanamycin, Streptomyces hygroscopicus; U-29135; Antibiotic (U-29,135); [(8E,12E,14Z)-6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate; [(8E,12Z,14E)-6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate; [(8Z,12Z,14Z)-6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate; [(3R,5R,6S,7R,10R,11R)-6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate; [(3R,5S,6R,7S,10R,11R)-6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate; [(3R,5S,6R,7S,10S,11S)-6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate; [(3S,5S,6R,7S,8E,10R,11S,12Z,14E)-6-Hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-8,12,14,18,21-pentaen-10-yl] carbamate; [(3R,5R,6S,7R,8E,10R,11R,12Z,14E)-6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate; [(3R,5S,6R,7S,8E,10R,11R,12Z,14E)-6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate; [(3R,5S,6R,7S,8E,10S,11S,12Z,14E)-6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate; [(3S,5S,6R,7S,8E,10S,11S,12Z,14E)-6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate; (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate; (6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl) carbamate; [8S-(4E,6Z,8R*,9R*,10E,12R*,13S*,14R*,16S*)]-9-[(Aminocarbonyl)oxy]-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione; 2-Azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9,13-dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-, 9-carbamate (8CI); 2-Azabicyclo[16.3.1]docosane, geldanamycin deriv.
Indication
Disease Entry ICD 11 Status REF
Kidney cancer 2C90.0 Discontinued in Phase 2 [1]
Peripheral nerve damage ND56.4 Discontinued in Phase 2 [1]
Cross-matching ID
PubChem CID
5288382
ChEBI ID
CHEBI:5292
CAS Number
CAS 30562-34-6
TTD Drug ID
DMS7TC5

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Investigative Drug(s)
Discontinued Drug(s)
Preclinical Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Heat shock protein 90 alpha (HSP90A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cromoglicate DM74LZK Asthma CA23 Approved [4]
Amlexanox DM0DQM5 Respiratory tract inflammation CA07 Approved [4]
NVP-AUY922 DMTYXQF Multiple myeloma 2A83 Phase 2 [5]
BIIB-021 DMPAJ41 Breast cancer 2C60-2C65 Phase 2 [6]
KW-2478 DMJGL72 Solid tumour/cancer 2A00-2F9Z Phase 2 [7]
VER 50589 DMFLZPC Breast cancer 2C60-2C65 Phase 2 [5]
Tanespimycin DMNLQHK Breast cancer 2C60-2C65 Phase 2 [8]
Efungumab DMBHP56 Breast cancer 2C60-2C65 Phase 2 [9]
SNX-5422 DMIU0VP Haematological malignancy 2B33.Y Phase 1/2 [10]
PU3 DMJO0BP Solid tumour/cancer 2A00-2F9Z Phase 1 [5]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Heat shock 70 kDa protein 1A (HSPA1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [11]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [12]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [13]
Gefitinib DM15F0X Colon adenocarcinoma Approved [14]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [15]
Selenium DM25CGV N. A. N. A. Approved [16]
Etretinate DM2CZFA Keratosis ED56 Approved [17]
Methotrexate DM2TEOL Anterior urethra cancer Approved [18]
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [20]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NBAS subunit of NRZ tethering complex (NBAS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [21]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [24]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [16]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [25]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [26]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [27]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Transcription factor TFIIIB component B'' homolog (BDP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Arsenic DMTL2Y1 N. A. N. A. Approved [31]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [32]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [26]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [35]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [27]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Structural maintenance of chromosomes flexible hinge domain-containing protein 1 (SMCHD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [16]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [36]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [37]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [38]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [39]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [40]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Toll-like receptor 4 (TLR4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [18]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [41]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [43]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [44]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [45]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [46]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [41]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [47]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Golgi integral membrane protein 4 (GOLIM4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [43]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [47]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [47]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [48]
Testosterone enanthate DMB6871 N. A. N. A. Approved [49]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [47]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [47]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By RNA polymerase II elongation factor ELL2 (ELL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [50]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [51]
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [43]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [52]
Leflunomide DMR8ONJ Arthritis FA20 Approved [53]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [54]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [55]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [56]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ATP-dependent RNA helicase DDX3X (DDX3X)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [57]
Leflunomide DMR8ONJ Arthritis FA20 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [58]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [59]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [60]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [24]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [61]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [62]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor E2F3 (E2F3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [63]
Quercetin DM3NC4M Obesity 5B81 Approved [64]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [65]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [66]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Testosterone enanthate DMB6871 N. A. N. A. Approved [49]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Motexafin gadolinium DMEJKRF Brain cancer 2A00 Approved [65]
Menthol DMG2KW7 Back pain ME84.Z Approved [67]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [59]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein lin-7 homolog A (LIN7A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [63]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Testosterone DM7HUNW Hot flushes GA30 Approved [69]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [69]
Leflunomide DMR8ONJ Arthritis FA20 Approved [53]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [70]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [71]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [37]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [72]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [73]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Peripheral plasma membrane protein CASK (CASK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [74]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [36]
Testosterone DM7HUNW Hot flushes GA30 Approved [75]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [76]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [60]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [39]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [77]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Importin-8 (IPO8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [59]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [79]
DNCB DMDTVYC Immune System disease 4A01-4B41 Phase 2 [80]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [81]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [82]
Milchsaure DM462BT Pruritus EC90 Investigative [83]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Lysine-specific demethylase 6A (KDM6A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [84]
Testosterone DM7HUNW Hot flushes GA30 Approved [75]
Leflunomide DMR8ONJ Arthritis FA20 Approved [53]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Testosterone enanthate DMB6871 N. A. N. A. Approved [49]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [85]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mediator of RNA polymerase II transcription subunit 7 (MED7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [51]
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [85]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
Urethane DM7NSI0 N. A. N. A. Phase 4 [86]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [87]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [88]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By EGF-like repeat and discoidin I-like domain-containing protein 3 (EDIL3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [43]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [89]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [90]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [91]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [92]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [93]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [94]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Tolloid-like protein 1 (TLL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [95]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [96]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [97]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [98]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [3]
Sulforaphane DMQY3L0 Skin disease EA00-EM0Z Investigative [99]
⏷ Show the Full List of 6 Drug(s)
Drug(s) Affected By Ecotropic viral integration site 5 protein homolog (EVI5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Selenium DM25CGV N. A. N. A. Approved [16]
Methotrexate DM2TEOL Anterior urethra cancer Approved [63]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [76]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [27]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [24]
Arsenic DMTL2Y1 N. A. N. A. Approved [31]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [101]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB (MAN1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [102]
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [103]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [36]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [47]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [21]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [47]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [47]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Monocarboxylate transporter 2 (SLC16A7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [52]
Testosterone enanthate DMB6871 N. A. N. A. Approved [49]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [39]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [79]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [104]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [105]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (HCN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [106]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [72]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [107]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [108]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [109]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [26]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [3]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By mRNA-capping enzyme (RNGTT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [63]
Testosterone enanthate DMB6871 N. A. N. A. Approved [49]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [110]
AT13387 DM2B9E0 Melanoma 2C30 Phase 1 [111]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [87]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [112]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [26]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [113]
Milchsaure DM462BT Pruritus EC90 Investigative [83]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [27]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Plexin-A2 (PLXNA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [43]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [76]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [70]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [39]
Arsenic DMTL2Y1 N. A. N. A. Approved [31]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [73]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Rho-associated protein kinase 2 (ROCK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [95]
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [114]
Leflunomide DMR8ONJ Arthritis FA20 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [106]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [115]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [116]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [39]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Copine-3 (CPNE3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Haloperidol DM96SE0 Delirium Approved [117]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [21]
Testosterone enanthate DMB6871 N. A. N. A. Approved [49]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Benzatropine DMF7EXL Parkinsonian disorder Approved [117]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [56]
Arsenic DMTL2Y1 N. A. N. A. Approved [31]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
DNCB DMDTVYC Immune System disease 4A01-4B41 Phase 2 [118]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DnaJ homolog subfamily C member 13 (DNAJC13)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [59]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [79]
Urethane DM7NSI0 N. A. N. A. Phase 4 [86]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [26]
Torcetrapib DMDHYM7 Hyperlipidaemia 5C80 Discontinued in Phase 2 [119]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [120]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Phosphatase and actin regulator 2 (PHACTR2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [16]
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Leflunomide DMR8ONJ Arthritis FA20 Approved [53]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [121]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [79]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [122]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA-directed RNA polymerase III subunit RPC9 (CRCP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [63]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [21]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Arsenic DMTL2Y1 N. A. N. A. Approved [31]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [90]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [123]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [95]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Cyclin-K (CCNK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [124]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [21]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [125]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [88]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [35]
NS398 DMINUWH Endometriosis GA10 Terminated [126]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [35]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Pre-mRNA-processing factor 6 (PRPF6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [16]
Methotrexate DM2TEOL Anterior urethra cancer Approved [63]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [70]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Clozapine DMFC71L Schizophrenia 6A20 Approved [117]
Bortezomib DMNO38U Leukemia Approved [56]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [62]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [16]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein furry homolog-like (FRYL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [63]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [24]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [101]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [55]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [88]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [35]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Nuclear factor of activated T-cells 5 (NFAT5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [16]
Methotrexate DM2TEOL Anterior urethra cancer Approved [18]
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [43]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [127]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [19]
Testosterone enanthate DMB6871 N. A. N. A. Approved [49]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [58]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [37]
Sodium chloride DMM3950 Skin burns ME65.0 Approved [128]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase 14 (CDK14)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [43]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [48]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [59]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [79]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [88]
Torcetrapib DMDHYM7 Hyperlipidaemia 5C80 Discontinued in Phase 2 [119]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [35]
3R14S-OCHRATOXIN A DM2KEW6 Discovery agent N.A. Investigative [129]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glutaminase kidney isoform, mitochondrial (GLS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [63]
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [130]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [43]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [131]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [65]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [36]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [76]
LY2835219 DM93VBZ Breast cancer 2C60-2C65 Approved [132]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Semaphorin-3D (SEMA3D)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [75]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [71]
Folic Acid DMEMBJC Colorectal carcinoma Approved [133]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [72]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [32]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [107]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [108]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [134]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [26]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [95]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor ligand superfamily member 15 (TNFSF15)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [135]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [43]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [136]
Testosterone DM7HUNW Hot flushes GA30 Approved [69]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [69]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Clozapine DMFC71L Schizophrenia 6A20 Approved [137]
Menthol DMG2KW7 Back pain ME84.Z Approved [67]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [138]
Arsenic DMTL2Y1 N. A. N. A. Approved [139]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Polypyrimidine tract-binding protein 3 (PTBP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [140]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [44]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [21]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [39]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [35]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [82]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Angiopoietin-related protein 1 (ANGPTL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [141]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [3]
Leflunomide DMR8ONJ Arthritis FA20 Approved [53]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [21]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [115]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Permethrin DMZ0Q1G Pediculus capitis infestation 1G00.0 Approved [142]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [107]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By G1/S-specific cyclin-E2 (CCNE2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [143]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [144]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [145]
Methotrexate DM2TEOL Anterior urethra cancer Approved [63]
Quercetin DM3NC4M Obesity 5B81 Approved [64]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [146]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [147]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [148]
Testosterone DM7HUNW Hot flushes GA30 Approved [69]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [47]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fibronectin (FN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [149]
Methotrexate DM2TEOL Anterior urethra cancer Approved [18]
Quercetin DM3NC4M Obesity 5B81 Approved [150]
Aripiprazole DM3NUMH Bipolar I disorder Approved [151]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [152]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [153]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [52]
Ethacrynic acid DM60QMR Edema MG29 Approved [154]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [140]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [155]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NADH-ubiquinone oxidoreductase chain 6 (ND6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [58]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [37]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [156]
Urethane DM7NSI0 N. A. N. A. Phase 4 [86]
THAPSIGARGIN DMDMQIE N. A. N. A. Preclinical [157]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [158]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [37]
Deguelin DMXT7WG Esophageal squamous cell carcinoma 2E60.1 Investigative [159]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Interstitial collagenase (MMP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [143]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [160]
Etretinate DM2CZFA Keratosis ED56 Approved [161]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [162]
Methotrexate DM2TEOL Anterior urethra cancer Approved [135]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [163]
Quercetin DM3NC4M Obesity 5B81 Approved [164]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [165]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [166]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [167]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Platelet-derived growth factor subunit A (PDGFA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [51]
Ramipril DM2R68E Acute heart failure BD10-BD13 Approved [168]
Methotrexate DM2TEOL Anterior urethra cancer Approved [135]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Estrone DM5T6US Acne vulgaris ED80 Approved [170]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [36]
Leflunomide DMR8ONJ Arthritis FA20 Approved [53]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Integrin beta-3 (ITGB3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aspirin DM672AH Acute coronary syndrome BA41 Approved [171]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [172]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [173]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [174]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [175]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [176]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [177]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [39]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [73]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [178]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Plasminogen activator inhibitor 1 (SERPINE1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [179]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [180]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [181]
Methotrexate DM2TEOL Anterior urethra cancer Approved [182]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [183]
Quercetin DM3NC4M Obesity 5B81 Approved [184]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [185]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [186]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [187]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [136]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Endothelin-1 (EDN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [188]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [70]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [189]
Methotrexate DM2TEOL Anterior urethra cancer Approved [135]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [190]
Quercetin DM3NC4M Obesity 5B81 Approved [191]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [192]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [193]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [194]
Lisinopril DMUOK4C Chronic heart failure BD1Z Approved [195]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bifunctional glutamate/proline--tRNA ligase (EPRS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [51]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [47]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [47]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [47]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Testosterone enanthate DMB6871 N. A. N. A. Approved [49]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [47]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Thrombospondin-1 (THBS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [196]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [180]
Methotrexate DM2TEOL Anterior urethra cancer Approved [18]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [197]
Quercetin DM3NC4M Obesity 5B81 Approved [198]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [199]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [200]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [199]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [201]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [44]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Heat shock protein HSP 90-beta (HSP90AB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [202]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [203]
Selenium DM25CGV N. A. N. A. Approved [16]
Etretinate DM2CZFA Keratosis ED56 Approved [17]
Quercetin DM3NC4M Obesity 5B81 Approved [204]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [20]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [192]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [65]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [36]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Signal recognition particle receptor subunit alpha (SRPRA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [63]
Haloperidol DM96SE0 Delirium Approved [117]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [59]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [62]
Paclitaxel DMLB81S Breast carcinoma Approved [91]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [55]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [205]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Inhibin beta A chain (INHBA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [43]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [36]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [84]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [76]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [48]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [206]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [115]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [207]
Arsenic DMTL2Y1 N. A. N. A. Approved [208]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Hepatocyte growth factor receptor (MET)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cabozantinib DMIYDT4 Medullary thyroid gland carcinoma Approved [209]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [210]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [211]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [211]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [211]
Methotrexate DM2TEOL Anterior urethra cancer Approved [200]
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [211]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [212]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [200]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Apelin receptor early endogenous ligand (APELA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [71]
Ethanol DMDRQZU Chronic pain MG30 Approved [213]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [32]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [71]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [107]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [71]
PDX-101 DM6OC53 Plasma cell myeloma 2A83.1 Phase 2 [71]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [71]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Tissue factor pathway inhibitor (TFPI)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [214]
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [43]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Estrone DM5T6US Acne vulgaris ED80 Approved [214]
Testosterone DM7HUNW Hot flushes GA30 Approved [215]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [37]
Ethanol DMDRQZU Chronic pain MG30 Approved [213]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By 60 kDa heat shock protein, mitochondrial (HSPD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [203]
Etretinate DM2CZFA Keratosis ED56 Approved [17]
Methotrexate DM2TEOL Anterior urethra cancer Approved [63]
Quercetin DM3NC4M Obesity 5B81 Approved [216]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [20]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [217]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [218]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [52]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [65]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [219]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dystrophin (DMD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [95]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [103]
Thioguanine DM7NKEV Acute lymphocytic leukaemia 2B33.3 Approved [220]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [37]
Gentamicin DMKINJO Bacteremia 1A73 Approved [221]
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [222]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [223]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nucleoprotein TPR (TPR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [224]
Selenium DM25CGV N. A. N. A. Approved [16]
Quercetin DM3NC4M Obesity 5B81 Approved [35]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [192]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [127]
Testosterone enanthate DMB6871 N. A. N. A. Approved [49]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Benzatropine DMF7EXL Parkinsonian disorder Approved [117]
Clozapine DMFC71L Schizophrenia 6A20 Approved [117]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein C-ets-1 (ETS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [225]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [226]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [36]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [227]
Leflunomide DMR8ONJ Arthritis FA20 Approved [53]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [228]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [138]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Histone H1.3 (H1-3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [63]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [192]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [148]
Leflunomide DMR8ONJ Arthritis FA20 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [27]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [24]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [230]
Lucanthone DMZLBUO Solid tumour/cancer 2A00-2F9Z Approved [231]
Tamibarotene DM3G74J T-cell leukaemia 2A90 Phase 3 [192]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Atrial natriuretic peptide receptor 3 (NPR3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Folic Acid DMEMBJC Colorectal carcinoma Approved [133]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [138]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [90]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [232]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Vascular endothelial growth factor receptor 1 (FLT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [233]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [234]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [235]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [236]
Haloperidol DM96SE0 Delirium Approved [117]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [228]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [37]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Receptor-type tyrosine-protein phosphatase alpha (PTPRA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [51]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [103]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Mecamylamine DMGQFYB Essential hypertension BA00 Approved [237]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [51]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [238]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [237]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ras-related protein Rab-3B (RAB3B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [103]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [84]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [239]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [54]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [59]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [60]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Neurofibromin (NF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [35]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [103]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [65]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [44]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [48]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Motexafin gadolinium DMEJKRF Brain cancer 2A00 Approved [65]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [79]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By E3 ubiquitin-protein ligase CBL (CBL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [240]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [44]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [21]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Menthol DMG2KW7 Back pain ME84.Z Approved [67]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [116]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [24]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [101]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Prostaglandin G/H synthase 1 (PTGS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [241]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [106]
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [242]
Quercetin DM3NC4M Obesity 5B81 Approved [243]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [20]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [244]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [199]
Bupivacaine DM4PRFC Anaesthesia 9A78.6 Approved [245]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [199]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Splicing factor, proline- and glutamine-rich (SFPQ)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [203]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [192]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [36]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [21]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [246]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Clozapine DMFC71L Schizophrenia 6A20 Approved [117]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [24]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Receptor-type tyrosine-protein phosphatase delta (PTPRD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [103]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [44]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [236]
Testosterone enanthate DMB6871 N. A. N. A. Approved [49]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [59]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [247]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Probable ATP-dependent RNA helicase DDX6 (DDX6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Leflunomide DMR8ONJ Arthritis FA20 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [232]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [248]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [27]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Protein S100-A4 (S100A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [43]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [52]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [249]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [250]
Adenosine triphosphate DM79F6G Malnutrition 5B50-5B71 Approved [251]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [236]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [21]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Collagen alpha-1(VIII) chain (COL8A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [252]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [236]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [59]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [90]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Permethrin DMZ0Q1G Pediculus capitis infestation 1G00.0 Approved [142]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [107]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [253]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [254]
Quercetin DM3NC4M Obesity 5B81 Approved [255]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [185]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [187]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [256]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [250]
Testosterone DM7HUNW Hot flushes GA30 Approved [75]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [257]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcriptional enhancer factor TEF-1 (TEAD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [44]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [70]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Arsenic DMTL2Y1 N. A. N. A. Approved [31]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
Capecitabine DMTS85L Adenocarcinoma 2D40 Approved [258]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [25]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [26]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [35]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tripeptidyl-peptidase 2 (TPP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [75]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [259]
Hydroxyurea DMOQVU9 Chronic myelogenous leukaemia 2A20.0 Approved [259]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [79]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [259]
DNCB DMDTVYC Immune System disease 4A01-4B41 Phase 2 [80]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [260]
Torcetrapib DMDHYM7 Hyperlipidaemia 5C80 Discontinued in Phase 2 [119]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [248]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cell division cycle protein 27 homolog (CDC27)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [43]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [65]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Motexafin gadolinium DMEJKRF Brain cancer 2A00 Approved [65]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [101]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By G1/S-specific cyclin-D2 (CCND2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Selenium DM25CGV N. A. N. A. Approved [261]
Methotrexate DM2TEOL Anterior urethra cancer Approved [135]
Quercetin DM3NC4M Obesity 5B81 Approved [64]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [262]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [263]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [147]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [264]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [70]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NK-tumor recognition protein (NKTR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [16]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [265]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [127]
Testosterone enanthate DMB6871 N. A. N. A. Approved [49]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [24]
Arsenic DMTL2Y1 N. A. N. A. Approved [31]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [90]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Oxytocin receptor (OXTR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [43]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [236]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [70]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [60]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [266]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [62]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [267]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CAP-Gly domain-containing linker protein 1 (CLIP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [268]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [51]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [269]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [79]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [270]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sodium/calcium exchanger 1 (SLC8A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [223]
Arsenic DMTL2Y1 N. A. N. A. Approved [31]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [271]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [32]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [272]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [107]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [177]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [112]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [26]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA replication licensing factor MCM4 (MCM4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [143]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [74]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [197]
Quercetin DM3NC4M Obesity 5B81 Approved [273]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [130]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [43]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [36]
Testosterone DM7HUNW Hot flushes GA30 Approved [69]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [69]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [274]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Heat shock 70 kDa protein 4 (HSPA4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [275]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [202]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [203]
Methotrexate DM2TEOL Anterior urethra cancer Approved [18]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [276]
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [20]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [65]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Catenin alpha-1 (CTNNA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [74]
Selenium DM25CGV N. A. N. A. Approved [16]
Methotrexate DM2TEOL Anterior urethra cancer Approved [63]
Quercetin DM3NC4M Obesity 5B81 Approved [150]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [217]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [167]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [217]
Haloperidol DM96SE0 Delirium Approved [117]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [21]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [85]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Merlin (NF2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [74]
Selenium DM25CGV N. A. N. A. Approved [16]
Methotrexate DM2TEOL Anterior urethra cancer Approved [63]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [277]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [174]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [72]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [39]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [51]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fibrillin-1 (FBN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Etretinate DM2CZFA Keratosis ED56 Approved [161]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [130]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [43]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Leflunomide DMR8ONJ Arthritis FA20 Approved [53]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [228]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [56]
Paclitaxel DMLB81S Breast carcinoma Approved [278]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-6 receptor subunit beta (IL6ST)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [279]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [280]
Selenium DM25CGV N. A. N. A. Approved [16]
Quercetin DM3NC4M Obesity 5B81 Approved [19]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [185]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [43]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [281]
Lenalidomide DM6Q7U4 Adult T-cell leukemia/lymphoma Approved [282]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [282]
Testosterone DM7HUNW Hot flushes GA30 Approved [69]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glutamate receptor 3 (GRIA3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [283]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [284]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [95]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [43]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [285]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [286]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [287]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [73]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [279]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [51]
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [36]
Adenosine triphosphate DM79F6G Malnutrition 5B50-5B71 Approved [288]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [76]
Cantharidin DMBP5N3 Molluscum contagiosum infection 1E76 Approved [289]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [290]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cell surface glycoprotein MUC18 (MCAM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aspirin DM672AH Acute coronary syndrome BA41 Approved [291]
Haloperidol DM96SE0 Delirium Approved [117]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [70]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [174]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [89]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [59]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [72]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Matrin-3 (MATR3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [203]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [43]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [37]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [38]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [203]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [71]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [205]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcriptional regulator ATRX (ATRX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [102]
Selenium DM25CGV N. A. N. A. Approved [16]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [192]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [292]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [21]
Testosterone enanthate DMB6871 N. A. N. A. Approved [49]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Ethanol DMDRQZU Chronic pain MG30 Approved [213]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Microtubule-associated protein 1B (MAP1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [284]
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [43]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [36]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [84]
Leflunomide DMR8ONJ Arthritis FA20 Approved [53]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [19]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Folic Acid DMEMBJC Colorectal carcinoma Approved [293]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ras GTPase-activating-like protein IQGAP1 (IQGAP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [203]
Quercetin DM3NC4M Obesity 5B81 Approved [204]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [294]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [246]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Folic Acid DMEMBJC Colorectal carcinoma Approved [133]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [59]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nestin (NES)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [295]
Quercetin DM3NC4M Obesity 5B81 Approved [296]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [297]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [265]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [21]
Testosterone enanthate DMB6871 N. A. N. A. Approved [49]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Clozapine DMFC71L Schizophrenia 6A20 Approved [117]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [59]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear receptor subfamily 2 group C member 2 (NR2C2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [35]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [298]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
Urethane DM7NSI0 N. A. N. A. Phase 4 [86]
Fenretinide DMRD5SP Macular degeneration 9B78.3 Phase 3 [299]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [300]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [88]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By MAP kinase-activated protein kinase 2 (MAPKAPK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [301]
Methotrexate DM2TEOL Anterior urethra cancer Approved [302]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [303]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [304]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [36]
Sorbitol DMAN0DE Constipation DD91.1 Approved [301]
Bortezomib DMNO38U Leukemia Approved [56]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [305]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [90]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein ERGIC-53 (LMAN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [306]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [55]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [71]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear autoantigenic sperm protein (NASP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [16]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [130]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [43]
Testosterone DM7HUNW Hot flushes GA30 Approved [69]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [69]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [19]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [37]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Ethanol DMDRQZU Chronic pain MG30 Approved [213]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Matrix metalloproteinase-16 (MMP16)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [307]
Methotrexate DM2TEOL Anterior urethra cancer Approved [63]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [308]
Testosterone DM7HUNW Hot flushes GA30 Approved [69]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [69]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [206]
Paclitaxel DMLB81S Breast carcinoma Approved [309]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [310]
Arsenic DMTL2Y1 N. A. N. A. Approved [31]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Probable global transcription activator SNF2L2 (SMARCA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [303]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [36]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [21]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [54]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [79]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By AF4/FMR2 family member 3 (AFF3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [44]
Testosterone DM7HUNW Hot flushes GA30 Approved [69]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [76]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [55]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [59]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [311]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [312]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Arf-GAP domain and FG repeat-containing protein 1 (AGFG1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [61]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [79]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [32]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [35]
PMID28870136-Compound-48 DMPIM9L N. A. N. A. Patented [102]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [27]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription initiation factor IIA subunit 1 (GTF2A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [313]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [314]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Folic Acid DMEMBJC Colorectal carcinoma Approved [133]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [315]
Arsenic DMTL2Y1 N. A. N. A. Approved [31]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [73]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Arfaptin-1 (ARFIP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [36]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Methotrexate DM2TEOL Anterior urethra cancer Approved [91]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [35]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [82]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [27]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By E3 ubiquitin-protein ligase TTC3 (TTC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [102]
Selenium DM25CGV N. A. N. A. Approved [16]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [192]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [127]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [21]
Testosterone enanthate DMB6871 N. A. N. A. Approved [49]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [316]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [316]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Calcipressin-1 (RCAN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [317]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Testosterone DM7HUNW Hot flushes GA30 Approved [69]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [69]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [21]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [318]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [316]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [316]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [317]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Monocarboxylate transporter 1 (SLC16A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [51]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [199]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [319]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [199]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [65]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [226]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [320]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [21]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cadherin-4 (CDH4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [321]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [138]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [322]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [59]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [38]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [39]
Arsenic DMTL2Y1 N. A. N. A. Approved [31]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [101]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [323]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein arginine N-methyltransferase 2 (PRMT2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [16]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [324]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [192]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [76]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [37]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [73]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [32]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Integrin alpha-1 (ITGA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [325]
Leflunomide DMR8ONJ Arthritis FA20 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [138]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [326]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [39]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [306]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [107]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transmembrane protein 33 (TMEM33)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [21]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [24]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [40]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [81]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [88]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sestrin-3 (SESN3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [327]
Methotrexate DM2TEOL Anterior urethra cancer Approved [63]
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [84]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [71]
Capsaicin DMGMF6V Back pain ME84.Z Approved [328]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [206]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [59]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Actin-related protein 2 (ACTR2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [329]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [87]
PMID28870136-Compound-48 DMPIM9L N. A. N. A. Patented [330]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [331]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [27]
chloropicrin DMSGBQA Discovery agent N.A. Investigative [332]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Transforming growth factor beta-2 proprotein (TGFB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [333]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [185]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [334]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [335]
Testosterone DM7HUNW Hot flushes GA30 Approved [69]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [227]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [76]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [70]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [138]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tropomyosin alpha-4 chain (TPM4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [95]
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [336]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [36]
Leflunomide DMR8ONJ Arthritis FA20 Approved [53]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Ampicillin DMHWE7P Acute epiglottitis Approved [19]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [176]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Casein kinase II subunit alpha (CSNK2A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [16]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [226]
Quercetin DM3NC4M Obesity 5B81 Approved [337]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [226]
Adenosine triphosphate DM79F6G Malnutrition 5B50-5B71 Approved [338]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Capsaicin DMGMF6V Back pain ME84.Z Approved [339]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase 6 (CDK6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [340]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [341]
Gefitinib DM15F0X Colon adenocarcinoma Approved [342]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [343]
Methotrexate DM2TEOL Anterior urethra cancer Approved [63]
Quercetin DM3NC4M Obesity 5B81 Approved [273]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [344]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [130]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [43]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By E3 ubiquitin-protein ligase Mdm2 (MDM2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [279]
Flucytosine DM13VTW Cryptococcal meningitis Approved [345]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [345]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [346]
Methotrexate DM2TEOL Anterior urethra cancer Approved [135]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [347]
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [348]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [65]
Amifostine DM5FL14 Mucositis CA00 Approved [349]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Spectrin beta chain, non-erythrocytic 1 (SPTBN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [350]
Leflunomide DMR8ONJ Arthritis FA20 Approved [53]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [21]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [58]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Menthol DMG2KW7 Back pain ME84.Z Approved [67]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [115]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [72]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By OTU domain-containing protein 4 (OTUD4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Folic Acid DMEMBJC Colorectal carcinoma Approved [133]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [101]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [32]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [35]
Torcetrapib DMDHYM7 Hyperlipidaemia 5C80 Discontinued in Phase 2 [119]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [71]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Transcription factor Sp4 (SP4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [351]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [43]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [351]
Testosterone DM7HUNW Hot flushes GA30 Approved [69]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [69]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [79]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
Vitamin C DMXJ7O8 Adenocarcinoma 2D40 Approved [352]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dystonin (DST)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [95]
Quercetin DM3NC4M Obesity 5B81 Approved [35]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [192]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [265]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [21]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Folic Acid DMEMBJC Colorectal carcinoma Approved [133]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Histone-lysine N-methyltransferase 2A (KMT2A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [353]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [354]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [44]
Testosterone enanthate DMB6871 N. A. N. A. Approved [49]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Ethanol DMDRQZU Chronic pain MG30 Approved [355]
Clozapine DMFC71L Schizophrenia 6A20 Approved [356]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [357]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [24]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transducin-like enhancer protein 4 (TLE4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [43]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [138]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [322]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [59]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [318]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [24]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [73]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tyrosine-protein phosphatase non-receptor type 12 (PTPN12)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [63]
Quercetin DM3NC4M Obesity 5B81 Approved [35]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Leflunomide DMR8ONJ Arthritis FA20 Approved [53]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [60]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [24]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caldesmon (CALD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [16]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [358]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [52]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [359]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [37]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Benzatropine DMF7EXL Parkinsonian disorder Approved [117]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [59]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [121]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By MBT domain-containing protein 1 (MBTD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [141]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [76]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [21]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [24]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [79]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [122]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [87]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CTD small phosphatase-like protein 2 (CTDSPL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [21]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [59]
Bortezomib DMNO38U Leukemia Approved [56]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [39]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [101]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [62]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tyrosine-protein phosphatase non-receptor type 11 (PTPN11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [360]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [361]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [362]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Bortezomib DMNO38U Leukemia Approved [56]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [315]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [51]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [79]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Son of sevenless homolog 2 (SOS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [227]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [76]
Leflunomide DMR8ONJ Arthritis FA20 Approved [53]
Testosterone enanthate DMB6871 N. A. N. A. Approved [49]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [116]
Arsenic DMTL2Y1 N. A. N. A. Approved [363]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ATP-dependent RNA helicase A (DHX9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [203]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [51]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [21]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [364]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [60]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [315]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [51]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [121]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Schlafen family member 5 (SLFN5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [3]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [274]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [138]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [72]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [365]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [79]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitotic-spindle organizing protein 1 (MZT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Testosterone DM7HUNW Hot flushes GA30 Approved [69]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [69]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [59]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [62]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [26]
PMID28870136-Compound-48 DMPIM9L N. A. N. A. Patented [102]
COUMESTROL DM40TBU Discovery agent N.A. Investigative [62]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Secernin-3 (SCRN3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [103]
Testosterone DM7HUNW Hot flushes GA30 Approved [75]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [79]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [366]
GALLICACID DM6Y3A0 Discovery agent N.A. Investigative [367]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [37]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [71]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By TP53-binding protein 1 (TP53BP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [35]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [27]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [368]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [369]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [315]
Arsenic DMTL2Y1 N. A. N. A. Approved [370]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [371]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Disks large homolog 1 (DLG1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [16]
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [21]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [56]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [38]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [79]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Pappalysin-1 (PAPPA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [130]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [43]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [265]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [236]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [106]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [138]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [59]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [115]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [110]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [372]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase kinase kinase 1 (MAP3K1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [273]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [236]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Menthol DMG2KW7 Back pain ME84.Z Approved [67]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [59]
Paclitaxel DMLB81S Breast carcinoma Approved [373]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Arsenic DMTL2Y1 N. A. N. A. Approved [374]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ras GTPase-activating protein-binding protein 1 (G3BP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Quercetin DM3NC4M Obesity 5B81 Approved [375]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [37]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [59]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [79]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [376]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Zinc transporter ZIP6 (SLC39A6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [203]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [377]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Gallium nitrate DMF9O6B Hypercalcaemia 5B91.0 Approved [378]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [73]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [203]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By cGMP-dependent protein kinase 1 (PRKG1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone enanthate DMB6871 N. A. N. A. Approved [49]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [107]
Methamphetamine DMPM4SK Anxiety Approved [379]
EXISULIND DMBY56U Colorectal cancer 2B91.Z Phase 3 [380]
CP-461 DMEYMTX Inflammatory bowel disease DD72 Phase 2 [380]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [88]
(5-(1-benzyl-1H-indazol-3-yl)furan-2-yl)methanol DM15P2G Discovery agent N.A. Investigative [380]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase 13 (CDK13)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [35]
Leflunomide DMR8ONJ Arthritis FA20 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Menthol DMG2KW7 Back pain ME84.Z Approved [67]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [247]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [123]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [381]
Urethane DM7NSI0 N. A. N. A. Phase 4 [86]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [16]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein Tob2 (TOB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [52]
Leflunomide DMR8ONJ Arthritis FA20 Approved [53]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [115]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [247]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
Urethane DM7NSI0 N. A. N. A. Phase 4 [86]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [16]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Enhancer of filamentation 1 (NEDD9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [199]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [199]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [47]
Leflunomide DMR8ONJ Arthritis FA20 Approved [53]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [47]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [47]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [47]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Inositol polyphosphate-5-phosphatase A (INPP5A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [110]
Arsenic DMTL2Y1 N. A. N. A. Approved [31]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [79]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Urethane DM7NSI0 N. A. N. A. Phase 4 [86]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [88]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bridge-like lipid transfer protein family member 2 (BLTP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [16]
Testosterone enanthate DMB6871 N. A. N. A. Approved [49]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [85]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [79]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [232]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [16]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [109]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [26]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [35]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Structural maintenance of chromosomes protein 1A (SMC1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [143]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [382]
Methotrexate DM2TEOL Anterior urethra cancer Approved [329]
Quercetin DM3NC4M Obesity 5B81 Approved [273]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [44]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Bleomycin DMNER5S Cervical cancer 2C77.0 Approved [382]
Bortezomib DMNO38U Leukemia Approved [56]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Disco-interacting protein 2 homolog A (DIP2A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [95]
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [21]
Testosterone enanthate DMB6871 N. A. N. A. Approved [49]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [38]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [35]
⏷ Show the Full List of 7 Drug(s)
Drug(s) Affected By Proteasome activator complex subunit 4 (PSME4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [203]
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [265]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Testosterone enanthate DMB6871 N. A. N. A. Approved [49]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [37]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [60]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 (ACAP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [60]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [101]
Urethane DM7NSI0 N. A. N. A. Phase 4 [86]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [112]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Early endosome antigen 1 (EEA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [75]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [71]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Chloroquine DMSI5CB Malaria 1F40-1F45 Approved [383]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [39]
Arsenic DMTL2Y1 N. A. N. A. Approved [31]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [79]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [26]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Pericentriolar material 1 protein (PCM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [295]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [102]
Selenium DM25CGV N. A. N. A. Approved [16]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [265]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [21]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [27]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [37]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Rab GTPase-binding effector protein 1 (RABEP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [63]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [59]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [85]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [112]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [26]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [35]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [35]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ankyrin repeat domain-containing protein 1 (ANKRD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [51]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Leflunomide DMR8ONJ Arthritis FA20 Approved [53]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [70]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Ethanol DMDRQZU Chronic pain MG30 Approved [384]
Folic Acid DMEMBJC Colorectal carcinoma Approved [385]
Ampicillin DMHWE7P Acute epiglottitis Approved [19]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [59]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Poly(rC)-binding protein 2 (PCBP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [36]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [386]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [21]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [37]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Benzatropine DMF7EXL Parkinsonian disorder Approved [117]
Arsenic DMTL2Y1 N. A. N. A. Approved [31]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [79]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Angiopoietin-1 (ANGPT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [387]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [51]
Selenium DM25CGV N. A. N. A. Approved [16]
Methotrexate DM2TEOL Anterior urethra cancer Approved [388]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [141]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [389]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [36]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear receptor coactivator 2 (NCOA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [196]
Selenium DM25CGV N. A. N. A. Approved [16]
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [298]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [73]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [196]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Probable JmjC domain-containing histone demethylation protein 2C (JMJD1C)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [390]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [37]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [39]
Arsenic DMTL2Y1 N. A. N. A. Approved [31]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [79]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [91]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [87]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Laminin subunit alpha-4 (LAMA4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [130]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [43]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [391]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [70]
Testosterone enanthate DMB6871 N. A. N. A. Approved [49]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [286]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [252]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [252]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Discoidin domain-containing receptor 2 (DDR2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [74]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [43]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [249]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [85]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [59]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [39]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [122]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [392]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA-binding protein RFX7 (RFX7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Testosterone DM7HUNW Hot flushes GA30 Approved [75]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [123]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [88]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [26]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [35]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By UPF0489 protein C5orf22 (C5ORF22)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Leflunomide DMR8ONJ Arthritis FA20 Approved [53]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [21]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [91]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [87]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [35]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [27]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Probable cation-transporting ATPase 13A5 (ATP13A5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Leflunomide DMR8ONJ Arthritis FA20 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [88]
Drug(s) Affected By N-acetyltransferase ESCO2 (ESCO2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Testosterone DM7HUNW Hot flushes GA30 Approved [69]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [69]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [106]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [37]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [56]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [393]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [24]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [73]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By N-acetyltransferase ESCO1 (ESCO1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Leflunomide DMR8ONJ Arthritis FA20 Approved [53]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [28]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [39]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [88]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [35]
Milchsaure DM462BT Pruritus EC90 Investigative [83]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [394]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [27]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA excision repair protein ERCC-6-like 2 (ERCC6L2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [59]
Arsenic DMTL2Y1 N. A. N. A. Approved [31]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [253]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [87]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [35]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [71]
⏷ Show the Full List of 7 Drug(s)
Drug(s) Affected By RNA-binding protein 26 (RBM26)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [63]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [59]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [24]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [79]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
DNCB DMDTVYC Immune System disease 4A01-4B41 Phase 2 [80]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [87]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sterile alpha motif domain-containing protein 5 (SAMD5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [43]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [59]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [395]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [25]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [71]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [107]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [88]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Protein PRR14L (PRR14L)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [63]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [27]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [24]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [232]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [35]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [35]
Milchsaure DM462BT Pruritus EC90 Investigative [83]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [394]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Myomegalin (PDE4DIP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [396]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [167]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Testosterone enanthate DMB6871 N. A. N. A. Approved [49]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Heroin diacetylmorphine DMDBWHY Neurological disorder 6B60 Approved [397]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [398]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [397]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [207]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Muscleblind-like protein 2 (MBNL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [43]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [265]
Leflunomide DMR8ONJ Arthritis FA20 Approved [53]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Testosterone enanthate DMB6871 N. A. N. A. Approved [49]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [106]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [399]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Little elongation complex subunit 2 (ICE2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [21]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Arsenic DMTL2Y1 N. A. N. A. Approved [363]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [90]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [400]
Epigallocatechin gallate DMCGWBJ Hepatic fibrosis DB93.0 Phase 3 [401]
PDX-101 DM6OC53 Plasma cell myeloma 2A83.1 Phase 2 [34]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By La-related protein 1B (LARP1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [44]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [76]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [37]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [115]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cell division cycle-associated protein 2 (CDCA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [51]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [65]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [148]
Testosterone DM7HUNW Hot flushes GA30 Approved [69]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [69]
Leflunomide DMR8ONJ Arthritis FA20 Approved [53]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [274]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [37]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nipped-B-like protein (NIPBL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [16]
Quercetin DM3NC4M Obesity 5B81 Approved [35]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [43]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [39]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
Urethane DM7NSI0 N. A. N. A. Phase 4 [86]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [311]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [16]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Methylcytosine dioxygenase TET2 (TET2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [402]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Leflunomide DMR8ONJ Arthritis FA20 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Arsenic DMTL2Y1 N. A. N. A. Approved [31]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [403]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
Urethane DM7NSI0 N. A. N. A. Phase 4 [86]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [34]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mis18-binding protein 1 (MIS18BP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Testosterone DM7HUNW Hot flushes GA30 Approved [69]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [69]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [19]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [89]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [393]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [39]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By SCY1-like protein 2 (SCYL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [103]
Testosterone DM7HUNW Hot flushes GA30 Approved [75]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [21]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Folic Acid DMEMBJC Colorectal carcinoma Approved [133]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [59]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
Urethane DM7NSI0 N. A. N. A. Phase 4 [86]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Superkiller complex protein 3 (SKIC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [16]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [60]
Arsenic DMTL2Y1 N. A. N. A. Approved [31]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [16]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [26]
PMID28870136-Compound-48 DMPIM9L N. A. N. A. Patented [102]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [115]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [71]
2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE DMNQL17 Discovery agent N.A. Investigative [404]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Serine protease FAM111B (FAM111B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [50]
Methotrexate DM2TEOL Anterior urethra cancer Approved [405]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [43]
Testosterone DM7HUNW Hot flushes GA30 Approved [69]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [69]
Leflunomide DMR8ONJ Arthritis FA20 Approved [53]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [37]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [406]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Kelch-like protein 24 (KLHL24)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [51]
Fluoxetine DM3PD2C Bipolar depression Approved [407]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [103]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [36]
Testosterone DM7HUNW Hot flushes GA30 Approved [75]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [70]
Testosterone enanthate DMB6871 N. A. N. A. Approved [49]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [407]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [37]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By BCL-6 corepressor (BCOR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [103]
Leflunomide DMR8ONJ Arthritis FA20 Approved [53]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [21]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [34]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [408]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [87]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By RNA-binding motif, single-stranded-interacting protein 3 (RBMS3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [43]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [39]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [73]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [123]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [71]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [107]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [109]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Very-long-chain (HACD2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Testosterone DM7HUNW Hot flushes GA30 Approved [75]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [236]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [115]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [365]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [39]
Arsenic DMTL2Y1 N. A. N. A. Approved [31]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ceramide synthase 6 (CERS6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [409]
Leflunomide DMR8ONJ Arthritis FA20 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [59]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [110]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [79]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [32]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [410]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Urethane DM7NSI0 N. A. N. A. Phase 4 [86]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein O-mannosyl-transferase TMTC3 (TMTC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [54]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [60]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [101]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [85]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [331]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [37]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [71]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By La-related protein 4 (LARP4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [226]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [52]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [106]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [79]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [62]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [267]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Phospholipid phosphatase-related protein type 4 (PLPPR4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [18]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [103]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Permethrin DMZ0Q1G Pediculus capitis infestation 1G00.0 Approved [142]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [88]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [120]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [27]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Nik-related protein kinase (NRK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [43]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [71]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [253]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [109]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [26]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [120]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [27]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Probable helicase senataxin (SETX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [117]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [47]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [47]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Clozapine DMFC71L Schizophrenia 6A20 Approved [117]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [59]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [47]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [87]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Coiled-coil domain-containing protein 186 (CCDC186)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [43]
Testosterone DM7HUNW Hot flushes GA30 Approved [75]
Leflunomide DMR8ONJ Arthritis FA20 Approved [53]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Bortezomib DMNO38U Leukemia Approved [56]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [40]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
Urethane DM7NSI0 N. A. N. A. Phase 4 [86]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [88]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By UPF0461 protein C5orf24 (C5ORF24)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [102]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
Urethane DM7NSI0 N. A. N. A. Phase 4 [86]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [71]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [87]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [88]
Torcetrapib DMDHYM7 Hyperlipidaemia 5C80 Discontinued in Phase 2 [119]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [71]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Protein prenyltransferase alpha subunit repeat-containing protein 1 (PTAR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [103]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [59]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Urethane DM7NSI0 N. A. N. A. Phase 4 [86]
Camptothecin DM6CHNJ Solid tumour/cancer 2A00-2F9Z Phase 3 [411]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [26]
Torcetrapib DMDHYM7 Hyperlipidaemia 5C80 Discontinued in Phase 2 [119]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [71]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Polypeptide N-acetylgalactosaminyltransferase 5 (GALNT5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [95]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [39]
Arsenic DMTL2Y1 N. A. N. A. Approved [31]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [73]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [107]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [108]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [366]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [26]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Pleckstrin homology-like domain family B member 2 (PHLDB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [50]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [95]
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [252]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [36]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [76]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [412]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Retrotransposon-derived protein PEG10 (PEG10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [252]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [413]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [414]
Testosterone DM7HUNW Hot flushes GA30 Approved [75]
Leflunomide DMR8ONJ Arthritis FA20 Approved [53]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Ethanol DMDRQZU Chronic pain MG30 Approved [384]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Rotatin (RTTN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [103]
Testosterone DM7HUNW Hot flushes GA30 Approved [69]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [69]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [21]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [59]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [101]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By RNA N6-adenosine-methyltransferase METTL16 (METTL16)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Torcetrapib DMDHYM7 Hyperlipidaemia 5C80 Discontinued in Phase 2 [119]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [394]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [415]
Drug(s) Affected By ATP-dependent RNA helicase DDX42 (DDX42)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [15]
Quercetin DM3NC4M Obesity 5B81 Approved [35]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [56]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [15]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
Urethane DM7NSI0 N. A. N. A. Phase 4 [86]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [35]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [35]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tripartite motif-containing protein 59 (TRIM59)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [50]
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [43]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [148]
Testosterone DM7HUNW Hot flushes GA30 Approved [69]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [69]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
Urethane DM7NSI0 N. A. N. A. Phase 4 [86]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [88]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Kelch repeat and BTB domain-containing protein 2 (KBTBD2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Leflunomide DMR8ONJ Arthritis FA20 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [56]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
Urethane DM7NSI0 N. A. N. A. Phase 4 [86]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [16]
Afimoxifene DMFORDT Breast cancer 2C60-2C65 Phase 2 [416]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [88]
Milchsaure DM462BT Pruritus EC90 Investigative [83]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Angiomotin-like protein 1 (AMOTL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [103]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [286]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [39]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [79]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [123]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [85]
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [417]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [418]
Torcetrapib DMDHYM7 Hyperlipidaemia 5C80 Discontinued in Phase 2 [119]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fanconi anemia group M protein (FANCM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [143]
Leflunomide DMR8ONJ Arthritis FA20 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [89]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [116]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [101]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [116]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [366]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [26]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Myocardin (MYOCD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [3]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [228]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [39]
Arsenic DMTL2Y1 N. A. N. A. Approved [31]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [410]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [107]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [34]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Abnormal spindle-like microcephaly-associated protein (ASPM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [405]
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [130]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [36]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [414]
Testosterone DM7HUNW Hot flushes GA30 Approved [69]
Riboflavin DM8YMWE Acne vulgaris ED80 Approved [419]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [69]
Leflunomide DMR8ONJ Arthritis FA20 Approved [53]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Retinol dehydrogenase 10 (RDH10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [420]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [138]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [89]
Pioglitazone DMKJ485 Amyotrophic lateral sclerosis 8B60.0 Approved [421]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [39]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [79]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mesoderm induction early response protein 1 (MIER1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [51]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Testosterone DM7HUNW Hot flushes GA30 Approved [75]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [21]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Folic Acid DMEMBJC Colorectal carcinoma Approved [133]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [88]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [26]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [35]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [95]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein phosphatase Mn(2+)-dependent 1K (PPM1K)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Tibolone DM78XFG Anabolic metabolism 5C50-5C8Z Approved [422]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [54]
Folic Acid DMEMBJC Colorectal carcinoma Approved [133]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [423]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [424]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [55]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein PHTF2 (PHTF2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [65]
Testosterone DM7HUNW Hot flushes GA30 Approved [69]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [69]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [37]
Motexafin gadolinium DMEJKRF Brain cancer 2A00 Approved [65]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [101]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Urethane DM7NSI0 N. A. N. A. Phase 4 [86]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Phospholipid-transporting ATPase IG (ATP11C)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [85]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [59]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [72]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [316]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [316]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [79]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [232]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [88]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [35]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fanconi anemia group B protein (FANCB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [143]
Methotrexate DM2TEOL Anterior urethra cancer Approved [63]
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [130]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Testosterone DM7HUNW Hot flushes GA30 Approved [69]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [69]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [21]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [322]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By EH domain-binding protein 1 (EHBP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [16]
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [43]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [76]
Leflunomide DMR8ONJ Arthritis FA20 Approved [53]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [110]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [79]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DCC-interacting protein 13-beta (APPL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [59]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [39]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [134]
Milchsaure DM462BT Pruritus EC90 Investigative [83]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Biorientation of chromosomes in cell division protein 1-like 1 (BOD1L1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [3]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [3]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [38]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [24]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [35]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [35]
methyl p-hydroxybenzoate DMO58UW Discovery agent N.A. Investigative [425]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Kinetochore scaffold 1 (KNL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [405]
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Testosterone DM7HUNW Hot flushes GA30 Approved [69]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [69]
Leflunomide DMR8ONJ Arthritis FA20 Approved [53]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [19]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ras association domain-containing protein 8 (RASSF8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [167]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [21]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [39]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [79]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [123]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [88]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [35]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Phosphatidylcholine:ceramide cholinephosphotransferase 2 (SGMS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [44]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [27]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [426]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [39]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [79]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [107]
Urethane DM7NSI0 N. A. N. A. Phase 4 [86]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [34]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cotranscriptional regulator ARB2A (ARB2A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [21]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [59]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [90]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
Urethane DM7NSI0 N. A. N. A. Phase 4 [86]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [112]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [37]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By LIM domain only protein 7 (LMO7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [51]
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [103]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [291]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [39]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [77]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By RUN and FYVE domain-containing protein 2 (RUFY2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [63]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [103]
Leflunomide DMR8ONJ Arthritis FA20 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Arsenic DMTL2Y1 N. A. N. A. Approved [31]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [79]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Urethane DM7NSI0 N. A. N. A. Phase 4 [86]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [16]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [95]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Histone acetyltransferase KAT6A (KAT6A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [95]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [24]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [427]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [35]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [35]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [95]
COUMESTROL DM40TBU Discovery agent N.A. Investigative [62]
GALLICACID DM6Y3A0 Discovery agent N.A. Investigative [367]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Probable ATP-dependent RNA helicase DDX17 (DDX17)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Selenium DM25CGV N. A. N. A. Approved [16]
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [428]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [390]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [47]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [47]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [21]
Testosterone enanthate DMB6871 N. A. N. A. Approved [49]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cullin-5 (CUL5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [429]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [136]
Testosterone enanthate DMB6871 N. A. N. A. Approved [49]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [59]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [79]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [430]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [431]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Lipoma-preferred partner (LPP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [95]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [130]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [217]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [217]
Leflunomide DMR8ONJ Arthritis FA20 Approved [53]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [21]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [59]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Leucine-rich repeat-containing protein 58 (LRRC58)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [76]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [27]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [59]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [316]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [39]
Arsenic DMTL2Y1 N. A. N. A. Approved [31]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [232]
Urethane DM7NSI0 N. A. N. A. Phase 4 [86]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [25]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Centrosomal protein of 95 kDa (CEP95)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [51]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [87]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [35]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [35]
QUERCITRIN DM1DH96 Discovery agent N.A. Investigative [432]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [37]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Ataxin-7-like protein 3B (ATXN7L3B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [192]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [21]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
Urethane DM7NSI0 N. A. N. A. Phase 4 [86]
Tamibarotene DM3G74J T-cell leukaemia 2A90 Phase 3 [192]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [433]
Torcetrapib DMDHYM7 Hyperlipidaemia 5C80 Discontinued in Phase 2 [119]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Kin of IRRE-like protein 1 (KIRREL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [63]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [71]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [366]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [27]
⏷ Show the Full List of 6 Drug(s)
Drug(s) Affected By Proton myo-inositol cotransporter (SLC2A13)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [39]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [73]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [253]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [25]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [120]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [27]
Manganese DMKT129 N. A. N. A. Investigative [434]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Centrosomal protein of 89 kDa (CEP89)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [51]
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [21]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [435]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [59]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [39]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [101]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [35]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase kinase kinase 5 (MAP3K5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [16]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [185]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [436]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [43]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [437]
Efavirenz DMC0GSJ Human immunodeficiency virus infection 1C62 Approved [438]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [439]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [59]
Levodopa DMN3E57 Parkinson disease 8A00.0 Approved [440]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Collagen alpha-1(XII) chain (COL12A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [43]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [70]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [115]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [39]
Arsenic DMTL2Y1 N. A. N. A. Approved [441]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [90]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [442]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Suppressor of IKBKE 1 (SIKE1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [63]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [21]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [435]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
PMID28870136-Compound-48 DMPIM9L N. A. N. A. Patented [102]
Torcetrapib DMDHYM7 Hyperlipidaemia 5C80 Discontinued in Phase 2 [119]
Milchsaure DM462BT Pruritus EC90 Investigative [83]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Protein LSM14 homolog B (LSM14B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [63]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [134]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [35]
Torcetrapib DMDHYM7 Hyperlipidaemia 5C80 Discontinued in Phase 2 [119]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [35]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serrate RNA effector molecule homolog (SRRT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [303]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [350]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Bortezomib DMNO38U Leukemia Approved [56]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [62]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [85]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [88]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [35]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [120]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Collagen alpha-1(XXV) chain (COL25A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [43]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [88]
Drug(s) Affected By Hyccin (HYCC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [95]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [76]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [54]
Folic Acid DMEMBJC Colorectal carcinoma Approved [293]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [101]
Urethane DM7NSI0 N. A. N. A. Phase 4 [86]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [443]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [35]
GALLICACID DM6Y3A0 Discovery agent N.A. Investigative [367]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Histone-lysine N-methyltransferase SETD2 (SETD2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [102]
Quercetin DM3NC4M Obesity 5B81 Approved [204]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [106]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [444]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
Berberine DMC5Q8X N. A. N. A. Phase 4 [445]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [16]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [427]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [87]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Oxysterol-binding protein-related protein 8 (OSBPL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [43]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [36]
Testosterone enanthate DMB6871 N. A. N. A. Approved [49]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [54]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [59]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [39]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [446]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By AP-5 complex subunit mu-1 (AP5M1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [21]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [59]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [79]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [447]
Topotecan DMP6G8T Central nervous system neoplasm Approved [91]
PDX-101 DM6OC53 Plasma cell myeloma 2A83.1 Phase 2 [71]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [27]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Sodium-coupled neutral amino acid symporter 1 (SLC38A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [95]
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [103]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [249]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [106]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [59]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [24]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Poly polymerase tankyrase-2 (TNKS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [109]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [26]
PJ34 DMXO6YH Coronavirus infection 1D92 Preclinical [448]
Milchsaure DM462BT Pruritus EC90 Investigative [83]
⏷ Show the Full List of 6 Drug(s)
Drug(s) Affected By HEAT repeat-containing protein 1 (HEATR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [51]
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [24]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [51]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [79]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [232]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Polyamine-transporting ATPase 13A3 (ATP13A3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [192]
Testosterone DM7HUNW Hot flushes GA30 Approved [75]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [79]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [232]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [449]
Tamibarotene DM3G74J T-cell leukaemia 2A90 Phase 3 [192]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [35]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Histone-lysine N-methyltransferase EHMT1 (EHMT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [450]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [70]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [72]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [51]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [451]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
YM155 DM5Q1W4 Breast cancer 2C60-2C65 Phase 2 [452]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dual specificity protein kinase CLK4 (CLK4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [102]
Methotrexate DM2TEOL Anterior urethra cancer Approved [63]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [36]
Leflunomide DMR8ONJ Arthritis FA20 Approved [53]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [19]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [270]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [88]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Centromere protein J (CENPJ)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Testosterone DM7HUNW Hot flushes GA30 Approved [69]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [69]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [59]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [101]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [453]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Band 4.1-like protein 5 (EPB41L5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [51]
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [37]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [59]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Arsenic DMTL2Y1 N. A. N. A. Approved [363]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [79]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Muscleblind-like protein 1 (MBNL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [16]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [43]
Leflunomide DMR8ONJ Arthritis FA20 Approved [53]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Bortezomib DMNO38U Leukemia Approved [56]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [38]
Indomethacin DMSC4A7 Bursitis Approved [454]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [79]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tropomodulin-3 (TMOD3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Haloperidol DM96SE0 Delirium Approved [117]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [21]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [101]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [449]
Urethane DM7NSI0 N. A. N. A. Phase 4 [86]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [455]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [35]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [95]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By RB-associated KRAB zinc finger protein (RBAK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
Fenretinide DMRD5SP Macular degeneration 9B78.3 Phase 3 [299]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [87]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [26]
QUERCITRIN DM1DH96 Discovery agent N.A. Investigative [432]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [394]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [27]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sentrin-specific protease 1 (SENP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [51]
Quercetin DM3NC4M Obesity 5B81 Approved [204]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [21]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [106]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [206]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Arsenic DMTL2Y1 N. A. N. A. Approved [31]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [81]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By MyoD family inhibitor domain-containing protein (MDFIC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [43]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [389]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [76]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [39]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [456]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [457]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By SLAIN motif-containing protein 2 (SLAIN2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [63]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [43]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [286]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [55]
Urethane DM7NSI0 N. A. N. A. Phase 4 [86]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [35]
Torcetrapib DMDHYM7 Hyperlipidaemia 5C80 Discontinued in Phase 2 [119]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [35]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Leucine--tRNA ligase, cytoplasmic (LARS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [103]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [47]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [47]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [47]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [59]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [47]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 (GNG12)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [389]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [54]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [39]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [79]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [85]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [88]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [26]
Torcetrapib DMDHYM7 Hyperlipidaemia 5C80 Discontinued in Phase 2 [119]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10D (TNFRSF10D)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [136]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [148]
Leflunomide DMR8ONJ Arthritis FA20 Approved [53]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [70]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [85]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [37]
Clozapine DMFC71L Schizophrenia 6A20 Approved [458]
Menthol DMG2KW7 Back pain ME84.Z Approved [67]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By LIM domain and actin-binding protein 1 (LIMA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [51]
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [459]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [44]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [37]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Bortezomib DMNO38U Leukemia Approved [56]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By AF4/FMR2 family member 4 (AFF4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [36]
Leflunomide DMR8ONJ Arthritis FA20 Approved [53]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [21]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [37]
Bortezomib DMNO38U Leukemia Approved [56]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Arsenic DMTL2Y1 N. A. N. A. Approved [460]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [79]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mediator of RNA polymerase II transcription subunit 13 (MED13)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [35]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [21]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [38]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [116]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [116]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [461]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [35]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/threonine-protein kinase tousled-like 1 (TLK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [95]
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [462]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [79]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [462]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [88]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [35]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [120]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By E3 ubiquitin-protein ligase HECTD1 (HECTD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [25]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [26]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [35]
Torcetrapib DMDHYM7 Hyperlipidaemia 5C80 Discontinued in Phase 2 [119]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [120]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [71]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/arginine repetitive matrix protein 2 (SRRM2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Quercetin DM3NC4M Obesity 5B81 Approved [35]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [127]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [21]
Testosterone enanthate DMB6871 N. A. N. A. Approved [49]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [462]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Clozapine DMFC71L Schizophrenia 6A20 Approved [117]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [59]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [24]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Short transient receptor potential channel 6 (TRPC6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Flufenamic Acid DMC8VNH Dysmenorrhea GA34.3 Approved [463]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [286]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [105]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [71]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [88]
AA-861 DMPEB0Z Allergy 4A80-4A85 Terminated [464]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [120]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [3]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By RAC-gamma serine/threonine-protein kinase (AKT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [103]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Menthol DMG2KW7 Back pain ME84.Z Approved [67]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [39]
Arsenic DMTL2Y1 N. A. N. A. Approved [31]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [73]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
Paclitaxel DMLB81S Breast carcinoma Approved [465]
Topotecan DMP6G8T Central nervous system neoplasm Approved [91]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Phospholipid-transporting ATPase IF (ATP11B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [21]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [79]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [424]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [55]
Urethane DM7NSI0 N. A. N. A. Phase 4 [86]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [95]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Calcium-binding protein 39 (CAB39)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [76]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [466]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [466]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Camptothecin DM6CHNJ Solid tumour/cancer 2A00-2F9Z Phase 3 [466]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [461]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [331]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Pygopus homolog 1 (PYGO1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [103]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [72]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [32]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [55]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [88]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [26]
Torcetrapib DMDHYM7 Hyperlipidaemia 5C80 Discontinued in Phase 2 [119]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Rap guanine nucleotide exchange factor 2 (RAPGEF2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Testosterone enanthate DMB6871 N. A. N. A. Approved [49]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Folic Acid DMEMBJC Colorectal carcinoma Approved [133]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Urethane DM7NSI0 N. A. N. A. Phase 4 [86]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [16]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [88]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [35]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [35]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Unconventional myosin-Va (MYO5A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [467]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [468]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [59]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [39]
Arsenic DMTL2Y1 N. A. N. A. Approved [31]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [101]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [123]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [85]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase kinase kinase kinase 5 (MAP4K5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [43]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Arsenic DMTL2Y1 N. A. N. A. Approved [31]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [90]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [32]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [449]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Krueppel-like factor 12 (KLF12)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [469]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [141]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [103]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [44]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [27]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [59]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [412]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [39]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [207]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein PRRC2C (PRRC2C)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [95]
Selenium DM25CGV N. A. N. A. Approved [16]
Quercetin DM3NC4M Obesity 5B81 Approved [35]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [192]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [390]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [21]
Testosterone enanthate DMB6871 N. A. N. A. Approved [49]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By FACT complex subunit SPT16 (SUPT16H)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [19]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
DNCB DMDTVYC Immune System disease 4A01-4B41 Phase 2 [80]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [87]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [19]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [35]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [82]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By GTP-binding protein SAR1b (SAR1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [16]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [43]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [70]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [58]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [34]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [366]
Milchsaure DM462BT Pruritus EC90 Investigative [83]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [27]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHUK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [470]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [471]
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [472]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [473]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [44]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [474]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [21]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [435]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Epidermal growth factor receptor (EGFR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
BIBW 2992 DMTKD7Q Non-small-cell lung cancer 2C25.Y Approved [475]
Gefitinib DM15F0X Colon adenocarcinoma Approved [476]
Erlotinib DMCMBHA Adrenal gland neoplasm Approved [477]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [478]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [479]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [480]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [13]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Selenium DM25CGV N. A. N. A. Approved [307]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [481]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Estrogen receptor (ESR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [482]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [483]
Gefitinib DM15F0X Colon adenocarcinoma Approved [484]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [485]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [478]
Liraglutide DM3FXPS Non-insulin dependent diabetes 5A11 Approved [486]
Quercetin DM3NC4M Obesity 5B81 Approved [487]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [488]
Procaine DM4LSNE Anaesthesia 9A78.6 Approved [485]
Estrone DM5T6US Acne vulgaris ED80 Approved [489]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By RAF proto-oncogene serine/threonine-protein kinase (RAF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [490]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [491]
Quercetin DM3NC4M Obesity 5B81 Approved [492]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [493]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [36]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [250]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [494]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [495]
Testosterone DM7HUNW Hot flushes GA30 Approved [496]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [227]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Receptor tyrosine-protein kinase erbB-2 (ERBB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Trastuzumab DMZQOUX Breast cancer 2C60-2C65 Approved [323]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [490]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [497]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [498]
Gefitinib DM15F0X Colon adenocarcinoma Approved [499]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [74]
Selenium DM25CGV N. A. N. A. Approved [16]
Methotrexate DM2TEOL Anterior urethra cancer Approved [135]
Quercetin DM3NC4M Obesity 5B81 Approved [64]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [43]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cellular tumor antigen p53 (TP53)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [500]
Methotrexate DM2TEOL Anterior urethra cancer Approved [18]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [348]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [501]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [502]
Paclitaxel DMLB81S Breast carcinoma Approved [503]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [504]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [505]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [506]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [341]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Large ribosomal subunit protein uL10 (RPLP0)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [507]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [36]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [508]
Arsenic DMTL2Y1 N. A. N. A. Approved [509]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [510]
Napabucasin DMDZ6Q3 Colorectal cancer 2B91.Z Phase 3 [511]
9-hydroxyoctadecadienoic acid DM0FWNJ Discovery agent N.A. Investigative [512]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Progesterone receptor (PGR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [513]
Drospirenone DM1A9W3 Acne vulgaris ED80 Approved [514]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [515]
Estrone DM5T6US Acne vulgaris ED80 Approved [516]
Tibolone DM78XFG Anabolic metabolism 5C50-5C8Z Approved [517]
Testosterone DM7HUNW Hot flushes GA30 Approved [518]
Exemestane DM9HPW3 Hormonally-responsive breast cancer 2C60-2C65 Approved [519]
Goserelin DMAT8CG Breast cancer 2C60-2C65 Approved [520]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [521]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [50]
Gefitinib DM15F0X Colon adenocarcinoma Approved [522]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [523]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [524]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [525]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [526]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [525]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [527]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [528]
Methotrexate DM2TEOL Anterior urethra cancer Approved [529]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [530]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [531]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [532]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [533]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [323]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [50]
Verapamil DMA7PEW Angina pectoris BA40 Approved [534]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [535]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [536]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [537]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Endoplasmic reticulum chaperone BiP (HSPA5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [202]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [538]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [539]
Etretinate DM2CZFA Keratosis ED56 Approved [17]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [369]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [540]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [541]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [542]
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [543]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase 4 (CDK4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [544]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [340]
Selenium DM25CGV N. A. N. A. Approved [261]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [545]
Methotrexate DM2TEOL Anterior urethra cancer Approved [135]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [546]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [547]
Quercetin DM3NC4M Obesity 5B81 Approved [64]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [130]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cadherin-1 (CDH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [548]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [549]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [550]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [551]
Liraglutide DM3FXPS Non-insulin dependent diabetes 5A11 Approved [486]
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [552]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [103]
Polyethylene glycol DM4I1JP Constipation DD91.1 Approved [553]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Endoplasmin (HSP90B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [202]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [203]
Selenium DM25CGV N. A. N. A. Approved [16]
Quercetin DM3NC4M Obesity 5B81 Approved [467]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [192]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [52]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [554]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [36]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [274]
Testosterone enanthate DMB6871 N. A. N. A. Approved [49]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [555]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [556]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [537]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [483]
Gefitinib DM15F0X Colon adenocarcinoma Approved [476]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [557]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [558]
Selenium DM25CGV N. A. N. A. Approved [16]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [559]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [560]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [561]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [562]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [563]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [536]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [564]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [565]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [566]
Gefitinib DM15F0X Colon adenocarcinoma Approved [567]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [568]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [569]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [570]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [562]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [571]
Paclitaxel DMLB81S Breast carcinoma Approved [572]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [573]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [561]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [323]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [279]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [536]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [564]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA-directed RNA polymerase II subunit RPB2 (POLR2B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [203]
Testosterone DM7HUNW Hot flushes GA30 Approved [75]
Leflunomide DMR8ONJ Arthritis FA20 Approved [53]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [203]
Afimoxifene DMFORDT Breast cancer 2C60-2C65 Phase 2 [203]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [248]
⏷ Show the Full List of 7 Drug(s)
Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [574]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [575]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [505]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [537]
Gefitinib DM15F0X Colon adenocarcinoma Approved [576]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [577]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [578]
Selenium DM25CGV N. A. N. A. Approved [16]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [579]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [559]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Aryl hydrocarbon receptor (AHR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [196]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [580]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [581]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [582]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [583]
Quercetin DM3NC4M Obesity 5B81 Approved [584]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [585]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [103]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [586]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [587]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 2 (MAP2K2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [490]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [588]
Selenium DM25CGV N. A. N. A. Approved [16]
Quercetin DM3NC4M Obesity 5B81 Approved [35]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [493]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [589]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [201]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [590]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [187]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [591]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [592]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [593]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [502]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [594]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [595]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [596]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [597]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [598]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [599]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-7 (CASP7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [600]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [13]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [601]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [602]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [603]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [603]
Methotrexate DM2TEOL Anterior urethra cancer Approved [135]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [604]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [605]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [606]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Eukaryotic initiation factor 4A-I (EIF4A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [57]
Methotrexate DM2TEOL Anterior urethra cancer Approved [63]
Quercetin DM3NC4M Obesity 5B81 Approved [607]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [608]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [70]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Paclitaxel DMLB81S Breast carcinoma Approved [609]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [116]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [51]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 1 (MAP2K1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [490]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [610]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [611]
Ethacrynic acid DM60QMR Edema MG29 Approved [612]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [265]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [250]
Testosterone DM7HUNW Hot flushes GA30 Approved [496]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [21]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Menthol DMG2KW7 Back pain ME84.Z Approved [67]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Focal adhesion kinase 1 (PTK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [565]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [613]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [197]
Quercetin DM3NC4M Obesity 5B81 Approved [614]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [429]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [615]
Testosterone DM7HUNW Hot flushes GA30 Approved [616]
Halothane DM80OZ5 Anaesthesia 9A78.6 Approved [617]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [70]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Potassium voltage-gated channel subfamily H member 2 (KCNH2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Metoclopramide DMFA5MY Nausea MD90 Approved [618]
Quinidine DMLPICK N. A. N. A. Approved [619]
Verapamil DMA7PEW Angina pectoris BA40 Approved [620]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [621]
Clarithromycin DM4M1SG Acute maxillary sinusitis Approved [621]
Disopyramide DM5SYZP Long QT syndrome BC65.0 Approved [622]
Propranolol DM79NTF Angina pectoris BA40 Approved [623]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [624]
Dofetilide DMPN1TW Sinus rhythm disorder BC9Y Approved [625]
Flecainide DMSQDLE Tachyarrhythmias BC71 Approved [621]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Hypoxia-inducible factor 1-alpha (HIF1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [626]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [627]
Prednisone DM2HG4X Acute asthma CA23 Approved [628]
Triamterene DM2HU9I Congestive heart failure BD10 Approved [628]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [629]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [630]
Epinephrine DM3KJBC Acute asthma CA23 Approved [631]
Quercetin DM3NC4M Obesity 5B81 Approved [632]
Fluoxetine DM3PD2C Bipolar depression Approved [633]
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [634]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Striatin-4 (STRN4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aspirin DM672AH Acute coronary syndrome BA41 Approved [226]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [85]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [23]
Arsenic DMTL2Y1 N. A. N. A. Approved [31]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [25]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [95]
Milchsaure DM462BT Pruritus EC90 Investigative [83]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [505]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [635]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [524]
Selenium DM25CGV N. A. N. A. Approved [16]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [636]
Methotrexate DM2TEOL Anterior urethra cancer Approved [135]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [345]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [637]
Quercetin DM3NC4M Obesity 5B81 Approved [273]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [20]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [47]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [272]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [638]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [327]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [639]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [640]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [641]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [642]
Quercetin DM3NC4M Obesity 5B81 Approved [643]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [141]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Heat shock protein 90 alpha (HSP90A) TT78R5H HS90A_HUMAN Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
60 kDa heat shock protein, mitochondrial (HSPD1) OTTO1Y11 CH60_HUMAN Gene/Protein Processing [3]
Abnormal spindle-like microcephaly-associated protein (ASPM) OTKXQMNA ASPM_HUMAN Gene/Protein Processing [3]
Actin-related protein 2 (ACTR2) OT3C8U5T ARP2_HUMAN Gene/Protein Processing [3]
AF4/FMR2 family member 3 (AFF3) OTR0705Z AFF3_HUMAN Gene/Protein Processing [3]
AF4/FMR2 family member 4 (AFF4) OTTL5Y8R AFF4_HUMAN Gene/Protein Processing [3]
Angiomotin-like protein 1 (AMOTL1) OT40G45S AMOL1_HUMAN Gene/Protein Processing [3]
Angiopoietin-1 (ANGPT1) OTVZ1NG3 ANGP1_HUMAN Gene/Protein Processing [3]
Angiopoietin-related protein 1 (ANGPTL1) OTXIN6V5 ANGL1_HUMAN Gene/Protein Processing [3]
Ankyrin repeat domain-containing protein 1 (ANKRD1) OTHJ7JV9 ANKR1_HUMAN Gene/Protein Processing [3]
AP-5 complex subunit mu-1 (AP5M1) OTDLWEBL AP5M1_HUMAN Gene/Protein Processing [3]

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005345)
2 Heat shock protein 90 regulates the stability of MEKK3 in HEK293 cells. Cell Immunol. 2009;259(1):49-55.
3 Identification of transcriptome signatures and biomarkers specific for potential developmental toxicants inhibiting human neural crest cell migration. Arch Toxicol. 2016 Jan;90(1):159-80.
4 Hsp90 is a direct target of the anti-allergic drugs disodium cromoglycate and amlexanox. Biochem J. 2003 Sep 1;374(Pt 2):433-41.
5 Recent advances in Hsp90 inhibitors as antitumor agents. Anticancer Agents Med Chem. 2008 Oct;8(7):761-82.
6 BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90. Mol Cancer Ther. 2009 Apr;8(4):921-9.
7 Anti-tumor activity against multiple myeloma by combination of KW-2478, an Hsp90 inhibitor, with bortezomib. Blood Cancer J. 2012 Apr;2(4):e68.
8 Tanespimycin: the opportunities and challenges of targeting heat shock protein 90. Expert Opin Investig Drugs. 2009 Jun;18(6):861-8.
9 Efungumab: a novel agent in the treatment of invasive candidiasis. Ann Pharmacother. 2009 Nov;43(11):1818-23.
10 SNX-2112, a selective Hsp90 inhibitor, potently inhibits tumor cell growth, angiogenesis, and osteoclastogenesis in multiple myeloma and other hema... Blood. 2009 Jan 22;113(4):846-55.
11 Serious carbamazepine-induced hypersensitivity reactions associated with the HSP70 gene cluster. Pharmacogenet Genomics. 2006 Apr;16(4):287-96. doi: 10.1097/01.fpc.0000189800.88596.7a.
12 Inhibiting Heat Shock Proteins Can Potentiate the Cytotoxic Effect of Cannabidiol in Human Glioma Cells. Anticancer Res. 2015 Nov;35(11):5827-37.
13 Sertraline induces endoplasmic reticulum stress in hepatic cells. Toxicology. 2014 Aug 1;322:78-88. doi: 10.1016/j.tox.2014.05.007. Epub 2014 May 24.
14 Reactive metabolite of gefitinib activates inflammasomes: implications for gefitinib-induced idiosyncratic reaction. J Toxicol Sci. 2020;45(11):673-680. doi: 10.2131/jts.45.673.
15 Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells. Cancer Res. 2002 Nov 1;62(21):6246-54.
16 Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
17 Consequences of the natural retinoid/retinoid X receptor ligands action in human breast cancer MDA-MB-231 cell line: Focus on functional proteomics. Toxicol Lett. 2017 Nov 5;281:26-34. doi: 10.1016/j.toxlet.2017.09.001. Epub 2017 Sep 5.
18 The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
19 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
20 Increased sensitivity for troglitazone-induced cytotoxicity using a human in vitro co-culture model. Toxicol In Vitro. 2009 Oct;23(7):1387-95.
21 Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
22 Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
23 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
24 Low doses of cisplatin induce gene alterations, cell cycle arrest, and apoptosis in human promyelocytic leukemia cells. Biomark Insights. 2016 Aug 24;11:113-21.
25 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
26 Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761. doi: 10.1016/j.taap.2019.114761. Epub 2019 Sep 15.
27 From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. Arch Toxicol. 2014 Jul;88(7):1451-68.
28 Anti-oncogenic and pro-differentiation effects of clorgyline, a monoamine oxidase A inhibitor, on high grade prostate cancer cells. BMC Med Genomics. 2009 Aug 20;2:55. doi: 10.1186/1755-8794-2-55.
29 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
30 Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
31 Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Toxicol Sci. 2015 Jan;143(1):97-106. doi: 10.1093/toxsci/kfu210. Epub 2014 Oct 10.
32 17-Estradiol Activates HSF1 via MAPK Signaling in ER-Positive Breast Cancer Cells. Cancers (Basel). 2019 Oct 11;11(10):1533. doi: 10.3390/cancers11101533.
33 Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
34 Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
35 Quantitative phosphoproteomics reveal cellular responses from caffeine, coumarin and quercetin in treated HepG2 cells. Toxicol Appl Pharmacol. 2022 Aug 15;449:116110. doi: 10.1016/j.taap.2022.116110. Epub 2022 Jun 7.
36 Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
37 Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
38 Clinical determinants of response to irinotecan-based therapy derived from cell line models. Clin Cancer Res. 2008 Oct 15;14(20):6647-55.
39 Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
40 Pharmacogenomic identification of novel determinants of response to chemotherapy in colon cancer. Cancer Res. 2006 Mar 1;66(5):2765-77.
41 Differential effects of statins on relevant functions of human monocyte-derived dendritic cells. J Leukoc Biol. 2006 Mar;79(3):529-38. doi: 10.1189/jlb.0205064. Epub 2005 Dec 30.
42 Quercetin regulates oxidized LDL induced inflammatory changes in human PBMCs by modulating the TLR-NF-B signaling pathway. Immunobiology. 2011 Mar;216(3):367-73. doi: 10.1016/j.imbio.2010.07.011. Epub 2010 Aug 19.
43 Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
44 THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders. Transl Psychiatry. 2018 Apr 25;8(1):89. doi: 10.1038/s41398-018-0137-3.
45 Mechanical stress-activated immune response genes via Sirtuin 1 expression in human periodontal ligament cells. Clin Exp Immunol. 2012 Apr;168(1):113-24. doi: 10.1111/j.1365-2249.2011.04549.x.
46 Primary Human Hepatocyte Spheroids as Tools to Study the Hepatotoxic Potential of Non-Pharmaceutical Chemicals. Int J Mol Sci. 2021 Oct 12;22(20):11005. doi: 10.3390/ijms222011005.
47 Transcriptomics hit the target: monitoring of ligand-activated and stress response pathways for chemical testing. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):7-18.
48 Cyclosporine A--induced oxidative stress in human renal mesangial cells: a role for ERK 1/2 MAPK signaling. Toxicol Sci. 2012 Mar;126(1):101-13.
49 Transcriptional profiling of testosterone-regulated genes in the skeletal muscle of human immunodeficiency virus-infected men experiencing weight loss. J Clin Endocrinol Metab. 2007 Jul;92(7):2793-802. doi: 10.1210/jc.2006-2722. Epub 2007 Apr 17.
50 Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
51 Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
52 Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May;1(3):177-87.
53 Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
54 The neuroprotective action of the mood stabilizing drugs lithium chloride and sodium valproate is mediated through the up-regulation of the homeodomain protein Six1. Toxicol Appl Pharmacol. 2009 Feb 15;235(1):124-34.
55 LSD1 activates a lethal prostate cancer gene network independently of its demethylase function. Proc Natl Acad Sci U S A. 2018 May 1;115(18):E4179-E4188.
56 The proapoptotic effect of zoledronic acid is independent of either the bone microenvironment or the intrinsic resistance to bortezomib of myeloma cells and is enhanced by the combination with arsenic trioxide. Exp Hematol. 2011 Jan;39(1):55-65.
57 Targetome analysis of chaperone-mediated autophagy in cancer cells. Autophagy. 2019 Sep;15(9):1558-1571. doi: 10.1080/15548627.2019.1586255. Epub 2019 Mar 20.
58 Integrated 'omics analysis reveals new drug-induced mitochondrial perturbations in human hepatocytes. Toxicol Lett. 2018 Jun 1;289:1-13.
59 Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
60 Identification of biomarkers and outcomes of endocrine disruption in human ovarian cortex using In Vitro Models. Toxicology. 2023 Feb;485:153425. doi: 10.1016/j.tox.2023.153425. Epub 2023 Jan 5.
61 Apoptosis induced by piroxicam plus cisplatin combined treatment is triggered by p21 in mesothelioma. PLoS One. 2011;6(8):e23569.
62 Pleiotropic combinatorial transcriptomes of human breast cancer cells exposed to mixtures of dietary phytoestrogens. Food Chem Toxicol. 2009 Apr;47(4):787-95.
63 Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
64 Inhibition of prostate cancer cell colony formation by the flavonoid quercetin correlates with modulation of specific regulatory genes. Clin Diagn Lab Immunol. 2004 Jan;11(1):63-9. doi: 10.1128/cdli.11.1.63-69.2004.
65 Motexafin gadolinium and zinc induce oxidative stress responses and apoptosis in B-cell lymphoma lines. Cancer Res. 2005 Dec 15;65(24):11676-88.
66 Activation of the p38 MAPK/Akt/ERK1/2 signal pathways is required for the protein stabilization of CDC6 and cyclin D1 in low-dose arsenite-induced cell proliferation. J Cell Biochem. 2010 Dec 15;111(6):1546-55. doi: 10.1002/jcb.22886.
67 Repurposing L-menthol for systems medicine and cancer therapeutics? L-menthol induces apoptosis through caspase 10 and by suppressing HSP90. OMICS. 2016 Jan;20(1):53-64.
68 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
69 Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
70 Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
71 A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
72 Identification by automated screening of a small molecule that selectively eliminates neural stem cells derived from hESCs but not dopamine neurons. PLoS One. 2009 Sep 23;4(9):e7155.
73 Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
74 Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells. Free Radic Biol Med. 2002 Nov 15;33(10):1419-32.
75 The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
76 Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol. 2005 Nov;19(11):2685-95.
77 Epidermal growth factor receptor signalling in human breast cancer cells operates parallel to estrogen receptor alpha signalling and results in tamoxifen insensitive proliferation. BMC Cancer. 2014 Apr 23;14:283.
78 DNA microarray analysis of changes in gene expression induced by 1,25-dihydroxyvitamin D3 in human promyelocytic leukemia HL-60 cells. Biomed Res. 2006 Jun;27(3):99-109. doi: 10.2220/biomedres.27.99.
79 Gene expression analysis of precision-cut human liver slices indicates stable expression of ADME-Tox related genes. Toxicol Appl Pharmacol. 2011 May 15;253(1):57-69.
80 Proteomic analysis of the cellular response to a potent sensitiser unveils the dynamics of haptenation in living cells. Toxicology. 2020 Dec 1;445:152603. doi: 10.1016/j.tox.2020.152603. Epub 2020 Sep 28.
81 Targeting MYCN in neuroblastoma by BET bromodomain inhibition. Cancer Discov. 2013 Mar;3(3):308-23.
82 Environmental pollutant induced cellular injury is reflected in exosomes from placental explants. Placenta. 2020 Jan 1;89:42-49. doi: 10.1016/j.placenta.2019.10.008. Epub 2019 Oct 17.
83 Transcriptional profiling of lactic acid treated reconstructed human epidermis reveals pathways underlying stinging and itch. Toxicol In Vitro. 2019 Jun;57:164-173.
84 Keratinocyte-derived IL-36gama plays a role in hydroquinone-induced chemical leukoderma through inhibition of melanogenesis in human epidermal melanocytes. Arch Toxicol. 2019 Aug;93(8):2307-2320.
85 Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay. Toxicol Sci. 2015 Aug;146(2):311-20. doi: 10.1093/toxsci/kfv094. Epub 2015 May 15.
86 Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.
87 Inhibiting ubiquitination causes an accumulation of SUMOylated newly synthesized nuclear proteins at PML bodies. J Biol Chem. 2019 Oct 18;294(42):15218-15234. doi: 10.1074/jbc.RA119.009147. Epub 2019 Jul 8.
88 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
89 Dasatinib reverses cancer-associated fibroblasts (CAFs) from primary lung carcinomas to a phenotype comparable to that of normal fibroblasts. Mol Cancer. 2010 Jun 27;9:168.
90 Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen. Clin Pharmacol Ther. 2016 Apr;99(4):432-41.
91 Gene expression profiling of 30 cancer cell lines predicts resistance towards 11 anticancer drugs at clinically achieved concentrations. Int J Cancer. 2006 Apr 1;118(7):1699-712. doi: 10.1002/ijc.21570.
92 Curcumin restores corticosteroid function in monocytes exposed to oxidants by maintaining HDAC2. Am J Respir Cell Mol Biol. 2008 Sep;39(3):312-23. doi: 10.1165/rcmb.2008-0012OC. Epub 2008 Apr 17.
93 Gene expression changes associated with altered growth and differentiation in benzo[a]pyrene or arsenic exposed normal human epidermal keratinocytes. J Appl Toxicol. 2008 May;28(4):491-508.
94 Regulation of chromatin assembly and cell transformation by formaldehyde exposure in human cells. Environ Health Perspect. 2017 Sep 21;125(9):097019.
95 DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.
96 Effect of benzo[a]pyrene on proliferation and metastasis of oral squamous cell carcinoma cells: A transcriptome analysis based on RNA-seq. Environ Toxicol. 2022 Nov;37(11):2589-2604. doi: 10.1002/tox.23621. Epub 2022 Jul 23.
97 Bisphenol A and bisphenol S induce distinct transcriptional profiles in differentiating human primary preadipocytes. PLoS One. 2016 Sep 29;11(9):e0163318.
98 Cellular reactions to long-term volatile organic compound (VOC) exposures. Sci Rep. 2016 Dec 1;6:37842. doi: 10.1038/srep37842.
99 Transcriptome and DNA methylation changes modulated by sulforaphane induce cell cycle arrest, apoptosis, DNA damage, and suppression of proliferation in human liver cancer cells. Food Chem Toxicol. 2020 Feb;136:111047. doi: 10.1016/j.fct.2019.111047. Epub 2019 Dec 12.
100 Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses. PLoS One. 2010 Dec 17;5(12):e14352. doi: 10.1371/journal.pone.0014352.
101 Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: application to acetaminophen injury. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):270-80.
102 Oxidative stress modulates theophylline effects on steroid responsiveness. Biochem Biophys Res Commun. 2008 Dec 19;377(3):797-802.
103 Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
104 Long-term estrogen exposure promotes carcinogen bioactivation, induces persistent changes in gene expression, and enhances the tumorigenicity of MCF-7 human breast cancer cells. Toxicol Appl Pharmacol. 2009 Nov 1;240(3):355-66.
105 Effects of progesterone treatment on expression of genes involved in uterine quiescence. Reprod Sci. 2011 Aug;18(8):781-97.
106 Stem cell transcriptome responses and corresponding biomarkers that indicate the transition from adaptive responses to cytotoxicity. Chem Res Toxicol. 2017 Apr 17;30(4):905-922.
107 Transcriptome and DNA methylome dynamics during triclosan-induced cardiomyocyte differentiation toxicity. Stem Cells Int. 2018 Oct 29;2018:8608327.
108 CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer. J Clin Invest. 2016 Feb;126(2):639-52.
109 Exome-wide mutation profile in benzo[a]pyrene-derived post-stasis and immortal human mammary epithelial cells. Mutat Res Genet Toxicol Environ Mutagen. 2014 Dec;775-776:48-54. doi: 10.1016/j.mrgentox.2014.10.011. Epub 2014 Nov 4.
110 The thioxotriazole copper(II) complex A0 induces endoplasmic reticulum stress and paraptotic death in human cancer cells. J Biol Chem. 2009 Sep 4;284(36):24306-19.
111 RNA-binding proteins and heat-shock protein 90 are constituents of the cytoplasmic capping enzyme interactome. J Biol Chem. 2018 Oct 26;293(43):16596-16607. doi: 10.1074/jbc.RA118.004973. Epub 2018 Aug 30.
112 Transcriptional signature of human macrophages exposed to the environmental contaminant benzo(a)pyrene. Toxicol Sci. 2010 Apr;114(2):247-59.
113 Epigenetic influences of low-dose bisphenol A in primary human breast epithelial cells. Toxicol Appl Pharmacol. 2010 Oct 15;248(2):111-21.
114 Ouabain-induced apoptosis and Rho kinase: a novel caspase-2 cleavage site and fragment of Rock-2. Apoptosis. 2010 Dec;15(12):1494-506. doi: 10.1007/s10495-010-0529-1.
115 Identification of mechanisms of action of bisphenol a-induced human preadipocyte differentiation by transcriptional profiling. Obesity (Silver Spring). 2014 Nov;22(11):2333-43.
116 Drug-induced endoplasmic reticulum and oxidative stress responses independently sensitize toward TNF-mediated hepatotoxicity. Toxicol Sci. 2014 Jul;140(1):144-59. doi: 10.1093/toxsci/kfu072. Epub 2014 Apr 20.
117 Cannabidiol Displays Proteomic Similarities to Antipsychotics in Cuprizone-Exposed Human Oligodendrocytic Cell Line MO3.13. Front Mol Neurosci. 2021 May 28;14:673144. doi: 10.3389/fnmol.2021.673144. eCollection 2021.
118 Microarray analyses in dendritic cells reveal potential biomarkers for chemical-induced skin sensitization. Mol Immunol. 2007 May;44(12):3222-33.
119 Clarifying off-target effects for torcetrapib using network pharmacology and reverse docking approach. BMC Syst Biol. 2012 Dec 10;6:152.
120 Bisphenol A induces DSB-ATM-p53 signaling leading to cell cycle arrest, senescence, autophagy, stress response, and estrogen release in human fetal lung fibroblasts. Arch Toxicol. 2018 Apr;92(4):1453-1469.
121 The effect of DNA methylation inhibitor 5-Aza-2'-deoxycytidine on human endometrial stromal cells. Hum Reprod. 2010 Nov;25(11):2859-69.
122 Cytosine arabinoside induces ectoderm and inhibits mesoderm expression in human embryonic stem cells during multilineage differentiation. Br J Pharmacol. 2011 Apr;162(8):1743-56.
123 Identification of novel low-dose bisphenol a targets in human foreskin fibroblast cells derived from hypospadias patients. PLoS One. 2012;7(5):e36711. doi: 10.1371/journal.pone.0036711. Epub 2012 May 4.
124 Genomic and proteomic analysis of the effects of cannabinoids on normal human astrocytes. Brain Res. 2008 Jan 29;1191:1-11.
125 Mechanism of cisplatin proximal tubule toxicity revealed by integrating transcriptomics, proteomics, metabolomics and biokinetics. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):117-27.
126 Detection of differentially expressed genes in human colon carcinoma cells treated with a selective COX-2 inhibitor. Oncogene. 2001 Jul 27;20(33):4450-6. doi: 10.1038/sj.onc.1204588.
127 Delta9-tetrahydrocannabinol inhibits cytotrophoblast cell proliferation and modulates gene transcription. Mol Hum Reprod. 2006 May;12(5):321-33. doi: 10.1093/molehr/gal036. Epub 2006 Apr 5.
128 Osmotic Induction of Angiogenic Growth Factor Expression in Human Retinal Pigment Epithelial Cells. PLoS One. 2016 Jan 22;11(1):e0147312. doi: 10.1371/journal.pone.0147312. eCollection 2016.
129 Linking site-specific loss of histone acetylation to repression of gene expression by the mycotoxin ochratoxin A. Arch Toxicol. 2018 Feb;92(2):995-1014.
130 Effects of ciglitazone and troglitazone on the proliferation of human stomach cancer cells. World J Gastroenterol. 2009 Jan 21;15(3):310-20.
131 Genomic profiling uncovers a molecular pattern for toxicological characterization of mutagens and promutagens in vitro. Toxicol Sci. 2011 Jul;122(1):185-97.
132 Biological specificity of CDK4/6 inhibitors: dose response relationship, in vivo signaling, and composite response signature. Oncotarget. 2017 Jul 4;8(27):43678-43691. doi: 10.18632/oncotarget.18435.
133 Folic acid supplementation dysregulates gene expression in lymphoblastoid cells--implications in nutrition. Biochem Biophys Res Commun. 2011 Sep 9;412(4):688-92. doi: 10.1016/j.bbrc.2011.08.027. Epub 2011 Aug 16.
134 Benzo[a]pyrene-induced changes in microRNA-mRNA networks. Chem Res Toxicol. 2012 Apr 16;25(4):838-49.
135 Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells. Tumour Biol. 2011 Oct;32(5):965-76.
136 Arsenic trioxide induces different gene expression profiles of genes related to growth and apoptosis in glioma cells dependent on the p53 status. Mol Biol Rep. 2008 Sep;35(3):421-9.
137 Histamine H4 receptor agonists have more activities than H4 agonism in antigen-specific human T-cell responses. Immunology. 2007 Jun;121(2):266-75. doi: 10.1111/j.1365-2567.2007.02574.x. Epub 2007 Mar 7.
138 Interleukin-19 as a translational indicator of renal injury. Arch Toxicol. 2015 Jan;89(1):101-6.
139 Prenatal arsenic exposure and shifts in the newborn proteome: interindividual differences in tumor necrosis factor (TNF)-responsive signaling. Toxicol Sci. 2014 Jun;139(2):328-37. doi: 10.1093/toxsci/kfu053. Epub 2014 Mar 27.
140 An approach to elucidate potential mechanism of renal toxicity of arsenic trioxide. Exp Hematol. 2007 Feb;35(2):252-62.
141 Rofecoxib modulates multiple gene expression pathways in a clinical model of acute inflammatory pain. Pain. 2007 Mar;128(1-2):136-47.
142 Exposure to Insecticides Modifies Gene Expression and DNA Methylation in Hematopoietic Tissues In Vitro. Int J Mol Sci. 2023 Mar 26;24(7):6259. doi: 10.3390/ijms24076259.
143 Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells. Toxicol Sci. 2023 Feb 17;191(2):227-238. doi: 10.1093/toxsci/kfac131.
144 mTOR inhibition reverses acquired endocrine therapy resistance of breast cancer cells at the cell proliferation and gene-expression levels. Cancer Sci. 2008 Oct;99(10):1992-2003. doi: 10.1111/j.1349-7006.2008.00955.x.
145 Utilization of CDKN1A/p21 gene for class discrimination of DNA damage-induced clastogenicity. Toxicology. 2014 Jan 6;315:8-16. doi: 10.1016/j.tox.2013.10.009. Epub 2013 Nov 6.
146 Retinoic acid-induced downmodulation of telomerase activity in human cancer cells. Exp Mol Pathol. 2005 Oct;79(2):108-17.
147 Zidovudine induces S-phase arrest and cell cycle gene expression changes in human cells. Mutagenesis. 2005 Mar;20(2):139-46. doi: 10.1093/mutage/gei019. Epub 2005 Mar 22.
148 In vitro effects of aldehydes present in tobacco smoke on gene expression in human lung alveolar epithelial cells. Toxicol In Vitro. 2013 Apr;27(3):1072-81.
149 Notoginsenoside R1 inhibits TNF-alpha-induced fibronectin production in smooth muscle cells via the ROS/ERK pathway. Free Radic Biol Med. 2006 May 1;40(9):1664-74. doi: 10.1016/j.freeradbiomed.2006.01.003. Epub 2006 Jan 26.
150 Integrated assessment by multiple gene expression analysis of quercetin bioactivity on anticancer-related mechanisms in colon cancer cells in vitro. Eur J Nutr. 2005 Mar;44(3):143-56. doi: 10.1007/s00394-004-0503-1. Epub 2004 Apr 30.
151 Small Molecule Antipsychotic Aripiprazole Potentiates Ozone-Induced Inflammation in Airway Epithelium. Chem Res Toxicol. 2019 Oct 21;32(10):1997-2005. doi: 10.1021/acs.chemrestox.9b00149. Epub 2019 Sep 11.
152 Peroxisome proliferator-activated receptor-gamma ligands suppress fibronectin gene expression in human lung carcinoma cells: involvement of both CRE and Sp1. Am J Physiol Lung Cell Mol Physiol. 2005 Sep;289(3):L419-28. doi: 10.1152/ajplung.00002.2005. Epub 2005 May 20.
153 Retinoic acid remodels extracellular matrix (ECM) of cultured human fetal palate mesenchymal cells (hFPMCs) through down-regulation of TGF-/Smad signaling. Toxicol Lett. 2014 Mar 3;225(2):208-15. doi: 10.1016/j.toxlet.2013.12.013. Epub 2013 Dec 24.
154 Ethacrynic acid exhibits selective toxicity to chronic lymphocytic leukemia cells by inhibition of the Wnt/beta-catenin pathway. PLoS One. 2009 Dec 14;4(12):e8294. doi: 10.1371/journal.pone.0008294.
155 Survival of retinal pigment epithelium after exposure to prolonged oxidative injury: a detailed gene expression and cellular analysis. Invest Ophthalmol Vis Sci. 2004 Oct;45(10):3767-77.
156 Mutation in mitochondrial complex I ND6 subunit is associated with defective response to hypoxia in human glioma cells. Mol Cancer. 2004 Jul 12;3:19. doi: 10.1186/1476-4598-3-19.
157 Endoplasmic reticulum stress impairs insulin signaling through mitochondrial damage in SH-SY5Y cells. Neurosignals. 2012;20(4):265-80.
158 Bisphenol A Exposure Changes the Transcriptomic and Proteomic Dynamics of Human Retinoblastoma Y79 Cells. Genes (Basel). 2021 Feb 11;12(2):264. doi: 10.3390/genes12020264.
159 Neurotoxicity and underlying cellular changes of 21 mitochondrial respiratory chain inhibitors. Arch Toxicol. 2021 Feb;95(2):591-615. doi: 10.1007/s00204-020-02970-5. Epub 2021 Jan 29.
160 Oxidative Stress-Protective and Anti-Melanogenic Effects of Loliolide and Ethanol Extract from Fresh Water Green Algae, Prasiola japonica. Int J Mol Sci. 2018 Sep 18;19(9):2825. doi: 10.3390/ijms19092825.
161 The effects of a novel synthetic retinoid, seletinoid G, on the expression of extracellular matrix proteins in aged human skin in vivo. Clin Chim Acta. 2005 Dec;362(1-2):161-9. doi: 10.1016/j.cccn.2005.06.016. Epub 2005 Aug 1.
162 Ciprofloxacin enhances the stimulation of matrix metalloproteinase 3 expression by interleukin-1beta in human tendon-derived cells. A potential mechanism of fluoroquinolone-induced tendinopathy. Arthritis Rheum. 2002 Nov;46(11):3034-40. doi: 10.1002/art.10617.
163 Simvastatin reduces MMP1 expression in human smooth muscle cells cultured on polymerized collagen by inhibiting Rac1 activation. Arterioscler Thromb Vasc Biol. 2007 May;27(5):1043-9. doi: 10.1161/ATVBAHA.107.139881. Epub 2007 Feb 15.
164 Quercetin inhibits matrix metalloproteinase-1 expression in human vascular endothelial cells through extracellular signal-regulated kinase. Arch Biochem Biophys. 2001 Jul 1;391(1):72-8. doi: 10.1006/abbi.2001.2402.
165 Rofecoxib regulates the expression of genes related to the matrix metalloproteinase pathway in humans: implication for the adverse effects of cyclooxygenase-2 inhibitors. Clin Pharmacol Ther. 2006 Apr;79(4):303-15. doi: 10.1016/j.clpt.2005.12.306.
166 Interaction between the aryl hydrocarbon receptor and retinoic acid pathways increases matrix metalloproteinase-1 expression in keratinocytes. J Biol Chem. 2004 Jun 11;279(24):25284-93. doi: 10.1074/jbc.M402168200. Epub 2004 Apr 9.
167 Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation. Blood. 2005 Jul 1;106(1):304-10.
168 Ramipril inhibits in vitro human mesangial cell proliferation and platelet-derived growth factor expression. Exp Nephrol. 1999 May-Jun;7(3):229-35. doi: 10.1159/000020606.
169 Retinoic acid receptor alpha amplifications and retinoic acid sensitivity in breast cancers. Clin Breast Cancer. 2013 Oct;13(5):401-8.
170 Atheroprotective effect of estriol and estrone sulfate on human vascular smooth muscle cells. J Steroid Biochem Mol Biol. 2000 Jan-Feb;72(1-2):71-8. doi: 10.1016/s0960-0760(99)00149-1.
171 Resistance in vitro to low-dose aspirin is associated with platelet PlA1 (GP IIIa) polymorphism but not with C807T(GP Ia/IIa) and C-5T Kozak (GP Ibalpha) polymorphisms. J Am Coll Cardiol. 2003 Sep 17;42(6):1115-9. doi: 10.1016/s0735-1097(03)00921-5.
172 Pro-apoptotic role of integrin 3 in glioma cells. J Neurochem. 2011 May;117(3):494-503. doi: 10.1111/j.1471-4159.2011.07219.x. Epub 2011 Mar 15.
173 In vitro dual effect of arsenic trioxide on hemopoiesis: inhibition of erythropoiesis and stimulation of megakaryocytic maturation. Blood Cells Mol Dis. 2006 Jan-Feb;36(1):59-76. doi: 10.1016/j.bcmd.2005.10.005. Epub 2005 Dec 15.
174 The differential cancer growth associated with anaesthetics in a cancer xenograft model of mice: mechanisms and implications of postoperative cancer recurrence. Cell Biol Toxicol. 2023 Aug;39(4):1561-1575. doi: 10.1007/s10565-022-09747-9. Epub 2022 Aug 12.
175 Grouping of histone deacetylase inhibitors and other toxicants disturbing neural crest migration by transcriptional profiling. Neurotoxicology. 2015 Sep;50:56-70.
176 Proteomic analysis of human adipose tissue after rosiglitazone treatment shows coordinated changes to promote glucose uptake. Obesity (Silver Spring). 2010 Jan;18(1):27-34. doi: 10.1038/oby.2009.208. Epub 2009 Jun 25.
177 Dose- and time-dependent transcriptional response of Ishikawa cells exposed to genistein. Toxicol Sci. 2016 May;151(1):71-87.
178 Progesterone regulation of implantation-related genes: new insights into the role of oestrogen. Cell Mol Life Sci. 2007 Apr;64(7-8):1009-32.
179 Decrease of plasminogen activator inhibitor-1 may contribute to the anti-invasive action of cannabidiol on human lung cancer cells. Pharm Res. 2010 Oct;27(10):2162-74. doi: 10.1007/s11095-010-0219-2. Epub 2010 Jul 29.
180 Unique signatures of stress-induced senescent human astrocytes. Exp Neurol. 2020 Dec;334:113466. doi: 10.1016/j.expneurol.2020.113466. Epub 2020 Sep 17.
181 Effect of spironolactone on impaired fibrinolysis of hypertensive patients. Kidney Blood Press Res. 2002;25(4):260-4. doi: 10.1159/000066348.
182 Association of cell cycle arrest with anticancer drug-induced epithelial-mesenchymal transition in alveolar epithelial cells. Toxicology. 2019 Aug 1;424:152231. doi: 10.1016/j.tox.2019.06.002. Epub 2019 Jun 4.
183 Simvastatin inhibits tissue factor and plasminogen activator inhibitor-1 secretion by peripheral blood mononuclear cells in patients with primary nephrotic syndrome. Eur J Med Res. 2007 May 29;12(5):216-21.
184 Polyphenols downregulate PAI-1 gene expression in cultured human coronary artery endothelial cells: molecular contributor to cardiovascular protection. Thromb Res. 2007;121(1):59-65. doi: 10.1016/j.thromres.2007.02.001. Epub 2007 Mar 26.
185 Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
186 Troglitazone reduces plasminogen activator inhibitor-1 expression and secretion in cultured human adipocytes. Diabetologia. 2000 Mar;43(3):377-83. doi: 10.1007/s001250050057.
187 Robustness testing and optimization of an adverse outcome pathway on cholestatic liver injury. Arch Toxicol. 2020 Apr;94(4):1151-1172. doi: 10.1007/s00204-020-02691-9. Epub 2020 Mar 10.
188 ?-adrenoceptors and muscarinic receptors mediate opposing effects on endothelin-1 expression in human lung fibroblasts. Eur J Pharmacol. 2012 Sep 15;691(1-3):218-24. doi: 10.1016/j.ejphar.2012.07.002. Epub 2012 Jul 13.
189 Induction of endothelin-1 expression by oxidative stress in vascular smooth muscle cells. Cardiovasc Pathol. 2001 Nov-Dec;10(6):311-5. doi: 10.1016/s1054-8807(01)00095-3.
190 [Effect of simvastatin on endothelin-1 expression in endothelial cell cultured hypoxically]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2008 Jan;39(1):72-5.
191 Effects of dietary polyphenols on gene expression in human vascular endothelial cells. Proc Nutr Soc. 2008 Feb;67(1):42-7.
192 Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis. Biochem Pharmacol. 2004 Dec 1;68(11):2177-86.
193 Nucleoside reverse transcriptase inhibitors induce a mitophagy-associated endothelial cytotoxicity that is reversed by coenzyme Q10 cotreatment. Toxicol Sci. 2013 Aug;134(2):323-34. doi: 10.1093/toxsci/kft105. Epub 2013 May 2.
194 Cardiac toxicity of high-dose cyclophosphamide in patients with multiple myeloma undergoing autologous hematopoietic stem cell transplantation. Int J Hematol. 2007 Jun;85(5):408-14. doi: 10.1532/IJH97.E0620.
195 Different effects of angiotensin converting enzyme inhibitors on endothelin-1 and nitric oxide balance in human vascular endothelial cells: evidence of an oxidant-sensitive pathway. Mediators Inflamm. 2008;2008:305087. doi: 10.1155/2008/305087. Epub 2008 Dec 1.
196 Arsenite and cadmium promote the development of mammary tumors. Carcinogenesis. 2020 Jul 14;41(7):1005-1014. doi: 10.1093/carcin/bgz176.
197 Simvastatin inactivates beta1-integrin and extracellular signal-related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells. Cancer Sci. 2007 Jun;98(6):890-9.
198 Hypoxia-inducible factor-1 (HIF-1) pathway activation by quercetin in human lens epithelial cells. Exp Eye Res. 2009 Dec;89(6):995-1002. doi: 10.1016/j.exer.2009.08.011. Epub 2009 Sep 1.
199 Retinoic acid and its 4-oxo metabolites are functionally active in human skin cells in vitro. J Invest Dermatol. 2005 Jul;125(1):143-53.
200 Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration. Arthritis Res Ther. 2009;11(1):R15.
201 Expression profile analysis of human peripheral blood mononuclear cells in response to aspirin. Arch Immunol Ther Exp (Warsz). 2005 Mar-Apr;53(2):151-8.
202 Cannabidiol Modulates the Expression of Alzheimer's Disease-Related Genes in Mesenchymal Stem Cells. Int J Mol Sci. 2016 Dec 23;18(1):26. doi: 10.3390/ijms18010026.
203 Comparative gene expression profiling reveals partially overlapping but distinct genomic actions of different antiestrogens in human breast cancer cells. J Cell Biochem. 2006 Aug 1;98(5):1163-84.
204 Quantitative proteomic analysis of HepG2 cells treated with quercetin suggests IQGAP1 involved in quercetin-induced regulation of cell proliferation and migration. OMICS. 2009 Apr;13(2):93-103. doi: 10.1089/omi.2008.0075.
205 Quantitative proteomics and transcriptomics addressing the estrogen receptor subtype-mediated effects in T47D breast cancer cells exposed to the phytoestrogen genistein. Mol Cell Proteomics. 2011 Jan;10(1):M110.002170.
206 Mifepristone induced progesterone withdrawal reveals novel regulatory pathways in human endometrium. Mol Hum Reprod. 2007 Sep;13(9):641-54.
207 Differential expression of microRNAs and their predicted targets in renal cells exposed to amphotericin B and its complex with copper (II) ions. Toxicol Mech Methods. 2017 Sep;27(7):537-543. doi: 10.1080/15376516.2017.1333554. Epub 2017 Jun 8.
208 Arsenic alters transcriptional responses to Pseudomonas aeruginosa infection and decreases antimicrobial defense of human airway epithelial cells. Toxicol Appl Pharmacol. 2017 Sep 15;331:154-163.
209 ROS-dependent DNA damage contributes to crizotinib-induced hepatotoxicity via the apoptotic pathway. Toxicol Appl Pharmacol. 2019 Nov 15;383:114768. doi: 10.1016/j.taap.2019.114768. Epub 2019 Oct 19.
210 Antitumor action of the MET tyrosine kinase inhibitor crizotinib (PF-02341066) in gastric cancer positive for MET amplification. Mol Cancer Ther. 2012 Jul;11(7):1557-64. doi: 10.1158/1535-7163.MCT-11-0934. Epub 2012 Jun 22.
211 An in vitro coculture system of human peripheral blood mononuclear cells with hepatocellular carcinoma-derived cells for predicting drug-induced liver injury. Arch Toxicol. 2021 Jan;95(1):149-168. doi: 10.1007/s00204-020-02882-4. Epub 2020 Aug 20.
212 All-trans retinoic acid inhibits the cell proliferation but enhances the cell invasion through up-regulation of c-met in pancreatic cancer cells. Cancer Lett. 2005 Jun 28;224(2):303-10. doi: 10.1016/j.canlet.2004.10.016. Epub 2004 Dec 8.
213 Gene expression signatures after ethanol exposure in differentiating embryoid bodies. Toxicol In Vitro. 2018 Feb;46:66-76.
214 Moving toward integrating gene expression profiling into high-throughput testing: a gene expression biomarker accurately predicts estrogen receptor alpha modulation in a microarray compendium. Toxicol Sci. 2016 May;151(1):88-103.
215 Mitogen-activated protein kinases pathway is involved in physiological testosterone-induced tissue factor pathway inhibitor expression in endothelial cells. Blood Coagul Fibrinolysis. 2010 Jul;21(5):420-4. doi: 10.1097/MBC.0b013e328337b475.
216 Identification of biomarkers for the initiation of apoptosis in human preneoplastic colonocytes by proteome analysis. Int J Cancer. 2004 Mar 20;109(2):220-9. doi: 10.1002/ijc.11692.
217 Comparison of the gene expression profiles of monocytic versus granulocytic lineages of HL-60 leukemia cell differentiation by DNA microarray analysis. Life Sci. 2003 Aug 15;73(13):1705-19. doi: 10.1016/s0024-3205(03)00515-0.
218 Lon protease and eiF2 are involved in acute, but not prolonged, antiretroviral induced stress response in HepG2 cells. Chem Biol Interact. 2016 May 25;252:82-6. doi: 10.1016/j.cbi.2016.03.021. Epub 2016 Apr 1.
219 Darinaparsin induces a unique cellular response and is active in an arsenic trioxide-resistant myeloma cell line. Mol Cancer Ther. 2009 May;8(5):1197-206.
220 The effect of 6-thioguanine on alternative splicing and antisense-mediated exon skipping treatment for duchenne muscular dystrophy. PLoS Curr. 2012 Dec 12;4:ecurrents.md.597d700f92eaa70de261ea0d91821377. doi: 10.1371/currents.md.597d700f92eaa70de261ea0d91821377.
221 Gentamicin administration in Duchenne patients with premature stop codon. Preliminary results. Acta Myol. 2003 May;22(1):15-21.
222 Identification of genomic biomarkers for anthracycline-induced cardiotoxicity in human iPSC-derived cardiomyocytes: an in vitro repeated exposure toxicity approach for safety assessment. Arch Toxicol. 2016 Nov;90(11):2763-2777.
223 Cell death mechanisms of the anti-cancer drug etoposide on human cardiomyocytes isolated from pluripotent stem cells. Arch Toxicol. 2018 Apr;92(4):1507-1524.
224 MS4A3-HSP27 target pathway reveals potential for haematopoietic disorder treatment in alimentary toxic aleukia. Cell Biol Toxicol. 2023 Feb;39(1):201-216. doi: 10.1007/s10565-021-09639-4. Epub 2021 Sep 28.
225 Resveratrol inhibits hydrogen peroxide-induced apoptosis in endothelial cells via the activation of PI3K/Akt by miR-126. J Atheroscler Thromb. 2014;21(2):108-18. doi: 10.5551/jat.19257. Epub 2013 Oct 10.
226 Expression profile analysis of colon cancer cells in response to sulindac or aspirin. Biochem Biophys Res Commun. 2002 Mar 29;292(2):498-512.
227 Ouabain impairs cell migration, and invasion and alters gene expression of human osteosarcoma U-2 OS cells. Environ Toxicol. 2017 Nov;32(11):2400-2413. doi: 10.1002/tox.22453. Epub 2017 Aug 10.
228 Evaluation of a human iPSC-derived BBB model for repeated dose toxicity testing with cyclosporine A as model compound. Toxicol In Vitro. 2021 Jun;73:105112. doi: 10.1016/j.tiv.2021.105112. Epub 2021 Feb 22.
229 Extremely low copper concentrations affect gene expression profiles of human prostate epithelial cell lines. Chem Biol Interact. 2010 Oct 6;188(1):214-9.
230 Proteomic analysis of antiproliferative effects by treatment of 5-fluorouracil in cervical cancer cells. DNA Cell Biol. 2004 Nov;23(11):769-76.
231 Lucanthone is a novel inhibitor of autophagy that induces cathepsin D-mediated apoptosis. J Biol Chem. 2011 Feb 25;286(8):6602-13.
232 Genistein and bisphenol A exposure cause estrogen receptor 1 to bind thousands of sites in a cell type-specific manner. Genome Res. 2012 Nov;22(11):2153-62.
233 Investigation of in vitro odonto/osteogenic capacity of cannabidiol on human dental pulp cell. J Dent. 2021 Jun;109:103673. doi: 10.1016/j.jdent.2021.103673. Epub 2021 Apr 16.
234 Effect of arsenic trioxide on vascular endothelial cell proliferation and expression of vascular endothelial growth factor receptors Flt-1 and KDR in gastric cancer in nude mice. World J Gastroenterol. 2007 Dec 28;13(48):6498-505. doi: 10.3748/wjg.v13.i48.6498.
235 9-Tetrahydrocannabinol leads to endoplasmic reticulum stress and mitochondrial dysfunction in human BeWo trophoblasts. Reprod Toxicol. 2019 Aug;87:21-31. doi: 10.1016/j.reprotox.2019.04.008. Epub 2019 May 1.
236 Identification of vitamin D3 target genes in human breast cancer tissue. J Steroid Biochem Mol Biol. 2016 Nov;164:90-97.
237 Nicotine modulates the expression of a diverse set of genes in the neuronal SH-SY5Y cell line. J Biol Chem. 2003 May 2;278(18):15633-40.
238 Transcriptional profiling in the human prefrontal cortex: evidence for two activational states associated with cocaine abuse. Pharmacogenomics J. 2003;3(1):27-40.
239 Thyroid hormone responsive genes in cultured human fibroblasts. J Clin Endocrinol Metab. 2005 Feb;90(2):936-43.
240 Arsenic trioxide induces apoptosis and G2/M phase arrest by inducing Cbl to inhibit PI3K/Akt signaling and thereby regulate p53 activation. Cancer Lett. 2009 Nov 1;284(2):208-15. doi: 10.1016/j.canlet.2009.04.035. Epub 2009 May 19.
241 Acetaminophen selectively suppresses peripheral prostaglandin E2 release and increases COX-2 gene expression in a clinical model of acute inflammation. Pain. 2007 Jun;129(3):279-86.
242 Mitochondrial involvement in schizophrenia and other functional psychoses. Neurochem Res. 1996 Sep;21(9):995-1004.
243 Quercetin reduces oxidative damage induced by paraquat via modulating expression of antioxidant genes in A549 cells. J Appl Toxicol. 2013 Dec;33(12):1460-7. doi: 10.1002/jat.2812. Epub 2012 Sep 20.
244 D-Penicillamine targets metastatic melanoma cells with induction of the unfolded protein response (UPR) and Noxa (PMAIP1)-dependent mitochondrial apoptosis. Apoptosis. 2012 Oct;17(10):1079-94.
245 The differential effects of bupivacaine and lidocaine on prostaglandin E2 release, cyclooxygenase gene expression and pain in a clinical pain model. Anesth Analg. 2008 Jan;106(1):321-7, table of contents.
246 Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21.
247 In vitro and in vivo irinotecan-induced changes in expression profiles of cell cycle and apoptosis-associated genes in acute myeloid leukemia cells. Mol Cancer Ther. 2005 Jun;4(6):885-900.
248 Low-dose Bisphenol A exposure alters the functionality and cellular environment in a human cardiomyocyte model. Environ Pollut. 2023 Oct 15;335:122359. doi: 10.1016/j.envpol.2023.122359. Epub 2023 Aug 9.
249 Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells. Nat Commun. 2018 Aug 9;9(1):3069. doi: 10.1038/s41467-018-05402-2.
250 Lunasin, a novel seed peptide, sensitizes human breast cancer MDA-MB-231 cells to aspirin-arrested cell cycle and induced apoptosis. Chem Biol Interact. 2010 Jul 30;186(2):127-34. doi: 10.1016/j.cbi.2010.04.027. Epub 2010 May 21.
251 Extracellular ATP drives breast cancer cell migration and metastasis via S100A4 production by cancer cells and fibroblasts. Cancer Lett. 2018 Aug 28;430:1-10. doi: 10.1016/j.canlet.2018.04.043. Epub 2018 May 5.
252 Transcriptomic analysis of untreated and drug-treated differentiated HepaRG cells over a 2-week period. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):27-35.
253 Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma. Oncotarget. 2014 May 15;5(9):2355-71.
254 Repression of Kisspeptin1 weakens hydrogen peroxide-caused injury in HTR8 cells via adjusting PI3K/AKT/mTOR pathway. J Biochem Mol Toxicol. 2020 May;34(5):e22461. doi: 10.1002/jbt.22461. Epub 2020 Feb 11.
255 Anticarcinogenic action of quercetin by downregulation of phosphatidylinositol 3-kinase (PI3K) and protein kinase C (PKC) via induction of p53 in hepatocellular carcinoma (HepG2) cell line. Mol Biol Rep. 2015 Sep;42(9):1419-29. doi: 10.1007/s11033-015-3921-7. Epub 2015 Aug 27.
256 Arsenic trioxide reduces the expression of E2F1, cyclin E, and phosphorylation of PI3K signaling molecules in acute leukemia cells. Environ Toxicol. 2021 Sep;36(9):1785-1792. doi: 10.1002/tox.23299. Epub 2021 May 27.
257 A systems biology understanding of the synergistic effects of arsenic sulfide and Imatinib in BCR/ABL-associated leukemia. Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3378-83.
258 Gene expression analysis using human cancer xenografts to identify novel predictive marker genes for the efficacy of 5-fluorouracil-based drugs. Cancer Sci. 2006 Jun;97(6):510-22. doi: 10.1111/j.1349-7006.2006.00204.x.
259 MAP kinase-signaling controls nuclear translocation of tripeptidyl-peptidase II in response to DNA damage and oxidative stress. Biochem Biophys Res Commun. 2010 Aug 27;399(3):324-30. doi: 10.1016/j.bbrc.2010.06.133. Epub 2010 Jul 17.
260 Comparison of quantitation methods in proteomics to define relevant toxicological information on AhR activation of HepG2 cells by BaP. Toxicology. 2021 Jan 30;448:152652. doi: 10.1016/j.tox.2020.152652. Epub 2020 Dec 2.
261 Selenite and selenomethionine promote HL-60 cell cycle progression. J Nutr. 2002 Apr;132(4):674-9. doi: 10.1093/jn/132.4.674.
262 Peroxisome proliferator-activated receptor ligands affect growth-related gene expression in human leukemic cells. J Pharmacol Exp Ther. 2003 Jun;305(3):932-42. doi: 10.1124/jpet.103.049098. Epub 2003 Mar 20.
263 Retinoid targeting of different D-type cyclins through distinct chemopreventive mechanisms. Cancer Res. 2005 Jul 15;65(14):6476-83. doi: 10.1158/0008-5472.CAN-05-0370.
264 1,25-Dihydroxyvitamin D3 suppresses gene expression of eukaryotic translation initiation factor 2 in human promyelocytic leukemia HL-60 cells. Cell Struct Funct. 2005;30(1):1-6. doi: 10.1247/csf.30.1.
265 Chronic occupational exposure to arsenic induces carcinogenic gene signaling networks and neoplastic transformation in human lung epithelial cells. Toxicol Appl Pharmacol. 2012 Jun 1;261(2):204-16.
266 Differential regulation of the p73 cistrome by mammalian target of rapamycin reveals transcriptional programs of mesenchymal differentiation and tumorigenesis. Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):2076-81. doi: 10.1073/pnas.1011936108. Epub 2011 Jan 18.
267 Coordinate up-regulation of TMEM97 and cholesterol biosynthesis genes in normal ovarian surface epithelial cells treated with progesterone: implications for pathogenesis of ovarian cancer. BMC Cancer. 2007 Dec 11;7:223.
268 Transcriptional up-regulation of restin by all-trans retinoic acid through STAT1 in cancer cell differentiation process. Biochem Biophys Res Commun. 2006 May 19;343(4):1009-16. doi: 10.1016/j.bbrc.2006.02.176. Epub 2006 Mar 9.
269 Gene expression in human hippocampus from cocaine abusers identifies genes which regulate extracellular matrix remodeling. PLoS One. 2007 Nov 14;2(11):e1187. doi: 10.1371/journal.pone.0001187.
270 High-throughput ectopic expression screen for tamoxifen resistance identifies an atypical kinase that blocks autophagy. Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):2058-63.
271 Identification of potential biomarkers of hepatitis B-induced acute liver failure using hepatic cells derived from human skin precursors. Toxicol In Vitro. 2015 Sep;29(6):1231-9. doi: 10.1016/j.tiv.2014.10.012. Epub 2014 Oct 24.
272 Functional cardiotoxicity assessment of cosmetic compounds using human-induced pluripotent stem cell-derived cardiomyocytes. Arch Toxicol. 2018 Jan;92(1):371-381.
273 Quercetin potentiates apoptosis by inhibiting nuclear factor-kappaB signaling in H460 lung cancer cells. Biol Pharm Bull. 2013;36(6):944-51. doi: 10.1248/bpb.b12-01004.
274 Inter-laboratory comparison of human renal proximal tubule (HK-2) transcriptome alterations due to Cyclosporine A exposure and medium exhaustion. Toxicol In Vitro. 2009 Apr;23(3):486-99.
275 Atrazine potentiation of arsenic trioxide-induced cytotoxicity and gene expression in human liver carcinoma cells (HepG2). Mol Cell Biochem. 2001 Jun;222(1-2):49-59.
276 Simvastatin induces heat shock factor 1 in vascular endothelial cells. Atherosclerosis. 2006 Oct;188(2):265-73. doi: 10.1016/j.atherosclerosis.2005.10.045. Epub 2005 Dec 20.
277 Arsenic trioxide (As(2)O(3)) induced apoptosis and its mechanisms in a human esophageal squamous carcinoma cell line. Chin Med J (Engl). 2002 Feb;115(2):280-5.
278 Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell. 2009 Aug 21;138(4):645-659. doi: 10.1016/j.cell.2009.06.034. Epub 2009 Aug 13.
279 Cannabidiol Modulates the Immunophenotype and Inhibits the Activation of the Inflammasome in Human Gingival Mesenchymal Stem Cells. Front Physiol. 2016 Nov 24;7:559. doi: 10.3389/fphys.2016.00559. eCollection 2016.
280 Chronic senescent human mesenchymal stem cells as possible contributor to the wound healing disorder after exposure to the alkylating agent sulfur mustard. Arch Toxicol. 2021 Feb;95(2):727-747. doi: 10.1007/s00204-020-02946-5. Epub 2021 Jan 25.
281 Aspirin induces apoptosis through the blockade of IL-6-STAT3 signaling pathway in human glioblastoma A172 cells. Biochem Biophys Res Commun. 2009 Sep 18;387(2):342-7. doi: 10.1016/j.bbrc.2009.07.022. Epub 2009 Jul 10.
282 Circulating endothelial progenitor cells in multiple myeloma: implications and significance. Blood. 2005 Apr 15;105(8):3286-94. doi: 10.1182/blood-2004-06-2101. Epub 2004 Dec 23.
283 Genetic and clinical predictors of sexual dysfunction in citalopram-treated depressed patients. Neuropsychopharmacology. 2009 Jun;34(7):1819-28. doi: 10.1038/npp.2009.4. Epub 2009 Mar 18.
284 Gingival Stromal Cells as an In Vitro Model: Cannabidiol Modulates Genes Linked With Amyotrophic Lateral Sclerosis. J Cell Biochem. 2017 Apr;118(4):819-828. doi: 10.1002/jcb.25757. Epub 2016 Nov 28.
285 Early Transcriptomic Changes upon Thalidomide Exposure Influence the Later Neuronal Development in Human Embryonic Stem Cell-Derived Spheres. Int J Mol Sci. 2020 Aug 3;21(15):5564. doi: 10.3390/ijms21155564.
286 Design principles of concentration-dependent transcriptome deviations in drug-exposed differentiating stem cells. Chem Res Toxicol. 2014 Mar 17;27(3):408-20.
287 Cocaine-induced alterations in nucleus accumbens ionotropic glutamate receptor subunits in human and non-human primates. J Neurochem. 2005 Dec;95(6):1785-93. doi: 10.1111/j.1471-4159.2005.03517.x.
288 The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer. J Med Chem. 2008 Sep 25;51(18):5522-32. doi: 10.1021/jm800295d.
289 Cantharidin suppresses gastric cancer cell migration/invasion by inhibiting the PI3K/Akt signaling pathway via CCAT1. Chem Biol Interact. 2020 Feb 1;317:108939. doi: 10.1016/j.cbi.2020.108939. Epub 2020 Jan 13.
290 Atorvastatin induces MicroRNA-145 expression in HEPG2 cells via regulation of the PI3K/AKT signalling pathway. Chem Biol Interact. 2018 May 1;287:32-40. doi: 10.1016/j.cbi.2018.04.005. Epub 2018 Apr 6.
291 Effects of aspirin on metastasis-associated gene expression detected by cDNA microarray. Acta Pharmacol Sin. 2004 Oct;25(10):1327-33.
292 Integrated analysis of rifampicin-induced microRNA and gene expression changes in human hepatocytes. Drug Metab Pharmacokinet. 2014;29(4):333-40.
293 Folate deficiency in normal human fibroblasts leads to altered expression of genes primarily linked to cell signaling, the cytoskeleton and extracellular matrix. J Nutr Biochem. 2007 Aug;18(8):541-52. doi: 10.1016/j.jnutbio.2006.11.002. Epub 2007 Feb 22.
294 Tyrosine phosphorylation of the scaffold protein IQGAP1 in the MET pathway alters function. J Biol Chem. 2020 Dec 25;295(52):18105-18121. doi: 10.1074/jbc.RA120.015891. Epub 2020 Oct 21.
295 Cannabidiol Activates Neuronal Precursor Genes in Human Gingival Mesenchymal Stromal Cells. J Cell Biochem. 2017 Jun;118(6):1531-1546. doi: 10.1002/jcb.25815. Epub 2016 Dec 29.
296 Quercetin in elimination of tumor initiating stem-like and mesenchymal transformation property in head and neck cancer. Head Neck. 2013 Mar;35(3):413-9. doi: 10.1002/hed.22982. Epub 2012 Mar 16.
297 Effects of all-trans and 9-cis retinoic acid on differentiating human neural stem cells in vitro. Toxicology. 2023 Mar 15;487:153461. doi: 10.1016/j.tox.2023.153461. Epub 2023 Feb 16.
298 Dexamethasone controls aryl hydrocarbon receptor (AhR)-mediated CYP1A1 and CYP1A2 expression and activity in primary cultures of human hepatocytes. Chem Biol Interact. 2009 May 15;179(2-3):288-96.
299 4-HPR modulates gene expression in ovarian cells. Int J Cancer. 2006 Sep 1;119(5):1005-13. doi: 10.1002/ijc.21797.
300 Changes in gene expressions elicited by physiological concentrations of genistein on human endometrial cancer cells. Mol Carcinog. 2006 Oct;45(10):752-63.
301 The phosphorylation of eukaryotic initiation factor eIF4E in response to phorbol esters, cell stresses, and cytokines is mediated by distinct MAP kinase pathways. J Biol Chem. 1998 Apr 17;273(16):9373-7. doi: 10.1074/jbc.273.16.9373.
302 Inflammation in methotrexate-induced pulmonary toxicity occurs via the p38 MAPK pathway. Toxicology. 2009 Feb 27;256(3):183-90. doi: 10.1016/j.tox.2008.11.016. Epub 2008 Nov 28.
303 Pharmacogenomic analysis of acute promyelocytic leukemia cells highlights CYP26 cytochrome metabolism in differential all-trans retinoic acid sensitivity. Blood. 2007 May 15;109(10):4450-60.
304 Pregnane X receptor PXR activates the GADD45beta gene, eliciting the p38 MAPK signal and cell migration. J Biol Chem. 2011 Feb 4;286(5):3570-8. doi: 10.1074/jbc.M110.179812. Epub 2010 Dec 2.
305 Ornithine decarboxylase antizyme upregulates DNA-dependent protein kinase and enhances the nonhomologous end-joining repair of DNA double-strand breaks in human oral cancer cells. Biochemistry. 2007 Aug 7;46(31):8920-32. doi: 10.1021/bi7000328. Epub 2007 Jul 14.
306 Proteomic analysis of hepatic effects of phenobarbital in mice with humanized liver. Arch Toxicol. 2022 Oct;96(10):2739-2754. doi: 10.1007/s00204-022-03338-7. Epub 2022 Jul 26.
307 Inhibition of invasion and induction of apoptosis by selenium in human malignant brain tumour cells in vitro. Int J Oncol. 2007 May;30(5):1263-71.
308 Endoplasmic reticulum stress contributes to arsenic trioxide-induced intrinsic apoptosis in human umbilical and bone marrow mesenchymal stem cells. Environ Toxicol. 2016 Mar;31(3):314-28.
309 Marked regression of liver metastasis by combined therapy of ultrasound-mediated NF kappaB-decoy transfer and transportal injection of paclitaxel, in mouse. Int J Cancer. 2008 Apr 1;122(7):1645-56. doi: 10.1002/ijc.23280.
310 Up-regulated gene expression of angiogenesis factors in post-chemotherapeutic lung cancer tissues determined by cDNA macroarray. Oncol Rep. 2002 Jul-Aug;9(4):723-8.
311 Gene expression profiling in Ishikawa cells: a fingerprint for estrogen active compounds. Toxicol Appl Pharmacol. 2009 Apr 1;236(1):85-96.
312 Comparative Analysis of Transcriptomic Changes including mRNA and microRNA Expression Induced by the Xenoestrogens Zearalenone and Bisphenol A in Human Ovarian Cells. Toxins (Basel). 2023 Feb 9;15(2):140. doi: 10.3390/toxins15020140.
313 Transcription Factor IIA tau is associated with undifferentiated cells and its gene expression is repressed in primary neurons at the chromatin level in vivo. Stem Cells Dev. 2006 Apr;15(2):175-90. doi: 10.1089/scd.2006.15.175.
314 Arsenic-induced sumoylation of Mus81 is involved in regulating genomic stability. Cell Cycle. 2017 Apr 18;16(8):802-811. doi: 10.1080/15384101.2017.1302628. Epub 2017 Mar 20.
315 Gene expression profiling of breast cancer cells in response to gemcitabine: NF-kappaB pathway activation as a potential mechanism of resistance. Breast Cancer Res Treat. 2007 Apr;102(2):157-72.
316 Acute hypersensitivity of pluripotent testicular cancer-derived embryonal carcinoma to low-dose 5-aza deoxycytidine is associated with global DNA Damage-associated p53 activation, anti-pluripotency and DNA demethylation. PLoS One. 2012;7(12):e53003. doi: 10.1371/journal.pone.0053003. Epub 2012 Dec 27.
317 Oxidative and calcium stress regulate DSCR1 (Adapt78/MCIP1) protein. Free Radic Biol Med. 2003 Sep 1;35(5):528-39. doi: 10.1016/s0891-5849(03)00358-7.
318 Gene expression profile of human lymphoid CEM cells sensitive and resistant to glucocorticoid-evoked apoptosis. Genomics. 2003 Jun;81(6):543-55.
319 Differential gene expression in human hepatocyte cell lines exposed to the antiretroviral agent zidovudine. Arch Toxicol. 2014 Mar;88(3):609-23. doi: 10.1007/s00204-013-1169-3. Epub 2013 Nov 30.
320 Modulation of butyrate transport in Caco-2 cells. Naunyn Schmiedebergs Arch Pharmacol. 2009 Apr;379(4):325-36. doi: 10.1007/s00210-008-0372-x. Epub 2008 Nov 21.
321 Gene expression profiling of rheumatoid arthritis synovial cells treated with antirheumatic drugs. J Biomol Screen. 2007 Apr;12(3):328-40. doi: 10.1177/1087057107299261. Epub 2007 Mar 22.
322 Mitochondrial Uncoupling Induces Epigenome Remodeling and Promotes Differentiation in Neuroblastoma. Cancer Res. 2023 Jan 18;83(2):181-194. doi: 10.1158/0008-5472.CAN-22-1029.
323 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
324 Ribavirin inhibits the growth and ascites formation of hepatocellular carcinoma through downregulation of type I CARM1 and type II PRMT5. Toxicol Appl Pharmacol. 2022 Jan 15;435:115829. doi: 10.1016/j.taap.2021.115829. Epub 2021 Dec 14.
325 The retinoid anticancer signal: mechanisms of target gene regulation. Br J Cancer. 2005 Aug 8;93(3):310-8. doi: 10.1038/sj.bjc.6602700.
326 Transcriptional and epigenetic regulation of the integrin collagen receptor locus ITGA1-PELO-ITGA2. Biochim Biophys Acta. 2007 Sep-Oct;1769(9-10):546-58. doi: 10.1016/j.bbaexp.2007.06.004. Epub 2007 Jul 6.
327 Gypenosides protect retinal pigment epithelium cells from oxidative stress. Food Chem Toxicol. 2018 Feb;112:76-85.
328 Capsaicin inhibits the migration, invasion and EMT of renal cancer cells by inducing AMPK/mTOR-mediated autophagy. Chem Biol Interact. 2022 Oct 1;366:110043. doi: 10.1016/j.cbi.2022.110043. Epub 2022 Aug 28.
329 Distinct genetic profile in peripheral blood mononuclear cells of psoriatic arthritis patients treated with methotrexate and TNF-inhibitors. Clin Rheumatol. 2014 Dec;33(12):1815-21. doi: 10.1007/s10067-014-2807-8. Epub 2014 Oct 24.
330 Global expression profiling of theophylline response genes in macrophages: evidence of airway anti-inflammatory regulation. Respir Res. 2005 Aug 8;6(1):89. doi: 10.1186/1465-9921-6-89.
331 Isobaric tags for relative and absolute quantitation-based proteomics analysis of the effect of ginger oil on bisphenol A-induced breast cancer cell proliferation. Oncol Lett. 2021 Feb;21(2):101. doi: 10.3892/ol.2020.12362. Epub 2020 Dec 8.
332 Transcriptomic analysis of human primary bronchial epithelial cells after chloropicrin treatment. Chem Res Toxicol. 2015 Oct 19;28(10):1926-35.
333 TGF-1 signaling protects retinal ganglion cells from oxidative stress via modulation of the HO-1/Nrf2 pathway. Chem Biol Interact. 2020 Nov 1;331:109249. doi: 10.1016/j.cbi.2020.109249. Epub 2020 Sep 24.
334 Troglitazone suppresses transforming growth factor beta-mediated fibrogenesis in retinal pigment epithelial cells. Mol Vis. 2008 Jan 18;14:95-104.
335 Towards dissecting the pathogenesis of retinoid-induced hair loss: all-trans retinoic acid induces premature hair follicle regression (catagen) by upregulation of transforming growth factor-beta2 in the dermal papilla. J Invest Dermatol. 2005 Jun;124(6):1119-26. doi: 10.1111/j.0022-202X.2005.23686.x.
336 Benzodithiophenes potentiate differentiation of acute promyelocytic leukemia cells by lowering the threshold for ligand-mediated corepressor/coactivator exchange with retinoic acid receptor alpha and enhancing changes in all-trans-retinoic acid-regulated gene expression. Cancer Res. 2005 Sep 1;65(17):7856-65. doi: 10.1158/0008-5472.CAN-05-1056.
337 Alternaria toxins as casein kinase 2 inhibitors and possible consequences for estrogenicity: a hybrid in silico/in vitro study. Arch Toxicol. 2020 Jun;94(6):2225-2237. doi: 10.1007/s00204-020-02746-x. Epub 2020 Apr 23.
338 Discovery and SAR of 5-(3-chlorophenylamino)benzo[c][2,6]naphthyridine-8-carboxylic acid (CX-4945), the first clinical stage inhibitor of protein kinase CK2 for the treatment of cancer. J Med Chem. 2011 Jan 27;54(2):635-54.
339 Capsaicin, a component of red peppers, stimulates protein kinase CKII activity. BMB Rep. 2010 May;43(5):325-9. doi: 10.5483/bmbrep.2010.43.5.325.
340 In vitro effects of cannabidiol and its main metabolites in mouse and human Sertoli cells. Food Chem Toxicol. 2022 Jan;159:112722. doi: 10.1016/j.fct.2021.112722. Epub 2021 Dec 3.
341 Fulvestrant induces resistance by modulating GPER and CDK6 expression: implication of methyltransferases, deacetylases and the hSWI/SNF chromatin remodelling complex. Br J Cancer. 2013 Nov 12;109(10):2751-62. doi: 10.1038/bjc.2013.583. Epub 2013 Oct 29.
342 Effects and mechanisms of betulinic acid on improving EGFR TKI-resistance of lung cancer cells. Environ Toxicol. 2018 Nov;33(11):1153-1159.
343 Sulindac induces specific degradation of the HPV oncoprotein E7 and causes growth arrest and apoptosis in cervical carcinoma cells. Cancer Lett. 2007 Jan 8;245(1-2):103-11. doi: 10.1016/j.canlet.2005.12.034. Epub 2006 Feb 20.
344 Involvement of the p38 MAPK signaling pathway in S-phase cell-cycle arrest induced by Furazolidone in human hepatoma G2 cells. J Appl Toxicol. 2013 Dec;33(12):1500-5. doi: 10.1002/jat.2829. Epub 2012 Oct 30.
345 Mechanisms of thymidine kinase/ganciclovir and cytosine deaminase/ 5-fluorocytosine suicide gene therapy-induced cell death in glioma cells. Oncogene. 2005 Feb 10;24(7):1231-43. doi: 10.1038/sj.onc.1208290.
346 In vitro antioxidant and antigenotoxic potentials of 3,5-O-di-galloylquinic acid extracted from Myrtus communis leaves and modulation of cell gene expression by H2O2. J Appl Toxicol. 2012 May;32(5):333-41.
347 HMG-CoA reductase inhibitors, statins, induce phosphorylation of Mdm2 and attenuate the p53 response to DNA damage. FASEB J. 2005 Mar;19(3):476-8. doi: 10.1096/fj.04-2745fje. Epub 2004 Dec 29.
348 Azidothymidine and cisplatin increase p14ARF expression in OVCAR-3 ovarian cancer cell line. Toxicol Appl Pharmacol. 2006 Oct 1;216(1):89-97. doi: 10.1016/j.taap.2006.04.015. Epub 2006 May 19.
349 Amifostine impairs p53-mediated apoptosis of human myeloid leukemia cells. Mol Cancer Ther. 2003 Sep;2(9):893-900.
350 Proteomics-based identification of differentially abundant proteins from human keratinocytes exposed to arsenic trioxide. J Proteomics Bioinform. 2014 Jul;7(7):166-178.
351 Arsenic trioxide downregulates specificity protein (Sp) transcription factors and inhibits bladder cancer cell and tumor growth. Exp Cell Res. 2010 Aug 1;316(13):2174-88. doi: 10.1016/j.yexcr.2010.04.027. Epub 2010 May 8.
352 Pharmacologic doses of ascorbic acid repress specificity protein (Sp) transcription factors and Sp-regulated genes in colon cancer cells. Nutr Cancer. 2011;63(7):1133-42. doi: 10.1080/01635581.2011.605984. Epub 2011 Sep 15.
353 Dietary flavonoids induce MLL translocations in primary human CD34+ cells. Carcinogenesis. 2007 Aug;28(8):1703-9. doi: 10.1093/carcin/bgm102. Epub 2007 Apr 29.
354 Differential responses to retinoic acid and endocrine disruptor compounds of subpopulations within human embryonic stem cell lines. Differentiation. 2012 Nov;84(4):330-43. doi: 10.1016/j.diff.2012.07.006. Epub 2012 Aug 18.
355 Alcohol triggered bile acid disequilibrium by suppressing BSEP to sustain hepatocellular carcinoma progression. Chem Biol Interact. 2022 Apr 1;356:109847. doi: 10.1016/j.cbi.2022.109847. Epub 2022 Feb 9.
356 Prefrontal dysfunction in schizophrenia involves mixed-lineage leukemia 1-regulated histone methylation at GABAergic gene promoters. J Neurosci. 2007 Oct 17;27(42):11254-62. doi: 10.1523/JNEUROSCI.3272-07.2007.
357 The broken MLL gene is frequently located outside the inherent chromosome territory in human lymphoid cells treated with DNA topoisomerase II poison etoposide. PLoS One. 2013 Sep 25;8(9):e75871. doi: 10.1371/journal.pone.0075871. eCollection 2013.
358 Cytoskeletal activation and altered gene expression in endothelial barrier regulation by simvastatin. Am J Respir Cell Mol Biol. 2004 May;30(5):662-70. doi: 10.1165/rcmb.2003-0267OC. Epub 2003 Nov 20.
359 Darinaparsin: solid tumor hypoxic cytotoxin and radiosensitizer. Clin Cancer Res. 2012 Jun 15;18(12):3366-76.
360 ATPR induces acute promyelocytic leukemia cells differentiation and growth arrest by blockade of SHP2/Rho/ROCK1 pathway. Toxicol Appl Pharmacol. 2020 Jul 15;399:115053. doi: 10.1016/j.taap.2020.115053. Epub 2020 May 15.
361 Arsenic trioxide induces apoptosis in NB-4, an acute promyelocytic leukemia cell line, through up-regulation of p73 via suppression of nuclear factor kappa B-mediated inhibition of p73 transcription and prevention of NF-kappaB-mediated induction of XIAP, cIAP2, BCL-XL and survivin. Med Oncol. 2010 Sep;27(3):833-42. doi: 10.1007/s12032-009-9294-9. Epub 2009 Sep 10.
362 Effects of lithium and valproic acid on gene expression and phenotypic markers in an NT2 neurosphere model of neural development. PLoS One. 2013;8(3):e58822.
363 Epigenetic changes in individuals with arsenicosis. Chem Res Toxicol. 2011 Feb 18;24(2):165-7. doi: 10.1021/tx1004419. Epub 2011 Feb 4.
364 Gene expression profiling of early primary biliary cirrhosis: possible insights into the mechanism of action of ursodeoxycholic acid. Liver Int. 2008 Aug;28(7):997-1010. doi: 10.1111/j.1478-3231.2008.01744.x. Epub 2008 Apr 15.
365 The genomic response of Ishikawa cells to bisphenol A exposure is dose- and time-dependent. Toxicology. 2010 Apr 11;270(2-3):137-49. doi: 10.1016/j.tox.2010.02.008. Epub 2010 Feb 17.
366 Identification of a transcriptomic signature of food-relevant genotoxins in human HepaRG hepatocarcinoma cells. Food Chem Toxicol. 2020 Jun;140:111297. doi: 10.1016/j.fct.2020.111297. Epub 2020 Mar 28.
367 Gene expression profile analysis of gallic acid-induced cell death process. Sci Rep. 2021 Aug 18;11(1):16743. doi: 10.1038/s41598-021-96174-1.
368 Etoposide induces necrosis through p53-mediated antiapoptosis in human kidney proximal tubule cells. Toxicol Sci. 2015 Nov;148(1):204-19.
369 High-content imaging-based BAC-GFP toxicity pathway reporters to assess chemical adversity liabilities. Arch Toxicol. 2017 Mar;91(3):1367-1383. doi: 10.1007/s00204-016-1781-0. Epub 2016 Jun 29.
370 Association of H3K79 monomethylation (an epigenetic signature) with arsenic-induced skin lesions. Mutat Res. 2018 Jan;807:1-9. doi: 10.1016/j.mrfmmm.2017.11.001. Epub 2017 Nov 14.
371 Effects of Benzophenone-3 and Propylparaben on Estrogen Receptor-Dependent R-Loops and DNA Damage in Breast Epithelial Cells and Mice. Environ Health Perspect. 2020 Jan;128(1):17002. doi: 10.1289/EHP5221. Epub 2020 Jan 15.
372 Metronomic gemcitabine suppresses tumour growth, improves perfusion, and reduces hypoxia in human pancreatic ductal adenocarcinoma. Br J Cancer. 2010 Jun 29;103(1):52-60.
373 Involvement of Asp-Glu-Val-Asp-directed, caspase-mediated mitogen-activated protein kinase kinase 1 Cleavage, c-Jun N-terminal kinase activation, and subsequent Bcl-2 phosphorylation for paclitaxel-induced apoptosis in HL-60 cells. Mol Pharmacol. 2001 Feb;59(2):254-62. doi: 10.1124/mol.59.2.254.
374 Arsenic and the epigenome: interindividual differences in arsenic metabolism related to distinct patterns of DNA methylation. J Biochem Mol Toxicol. 2013 Feb;27(2):106-15. doi: 10.1002/jbt.21462. Epub 2013 Jan 11.
375 Quercetin acts via the G3BP1/YWHAZ axis to inhibit glycolysis and proliferation in oral squamous cell carcinoma. Toxicol Mech Methods. 2023 Feb;33(2):141-150. doi: 10.1080/15376516.2022.2103480. Epub 2022 Aug 9.
376 The G Protein-Coupled Estrogen Receptor Agonist G-1 Inhibits Nuclear Estrogen Receptor Activity and Stimulates Novel Phosphoproteomic Signatures. Toxicol Sci. 2016 Jun;151(2):434-46. doi: 10.1093/toxsci/kfw057. Epub 2016 Mar 29.
377 Cellular zinc homeostasis is a regulator in monocyte differentiation of HL-60 cells by 1 alpha,25-dihydroxyvitamin D3. J Leukoc Biol. 2010 May;87(5):833-44. doi: 10.1189/jlb.0409241. Epub 2010 Jan 20.
378 Role of oxidative stress in the induction of metallothionein-2A and heme oxygenase-1 gene expression by the antineoplastic agent gallium nitrate in human lymphoma cells. Free Radic Biol Med. 2008 Sep 15;45(6):763-72.
379 Genome-wide association for methamphetamine dependence: convergent results from 2 samples. Arch Gen Psychiatry. 2008 Mar;65(3):345-55. doi: 10.1001/archpsyc.65.3.345.
380 Cyclic GMP-dependent protein kinase activation and induction by exisulind and CP461 in colon tumor cells. J Pharmacol Exp Ther. 2001 Nov;299(2):583-92.
381 Nicotinic modulation of gene expression in SH-SY5Y neuroblastoma cells. Brain Res. 2006 Oct 20;1116(1):39-49.
382 Direct activation of ATM by resveratrol under oxidizing conditions. PLoS One. 2014 Jun 16;9(6):e97969. doi: 10.1371/journal.pone.0097969. eCollection 2014.
383 Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion. Autophagy. 2018;14(8):1435-1455. doi: 10.1080/15548627.2018.1474314. Epub 2018 Jul 20.
384 Cardiac toxicity from ethanol exposure in human-induced pluripotent stem cell-derived cardiomyocytes. Toxicol Sci. 2019 May 1;169(1):280-292.
385 High folic acid increases cell turnover and lowers differentiation and iron content in human HT29 colon cancer cells. Br J Nutr. 2008 Apr;99(4):703-8.
386 JunD is involved in the antiproliferative effect of Delta9-tetrahydrocannabinol on human breast cancer cells. Oncogene. 2008 Aug 28;27(37):5033-44.
387 Cannabidiol induces osteoblast differentiation via angiopoietin1 and p38 MAPK. Environ Toxicol. 2020 Dec;35(12):1318-1325. doi: 10.1002/tox.22996. Epub 2020 Jul 13.
388 Effects of methotrexate on vascular endothelial growth factor, angiopoietin 1, and angiopoietin 2 in nasal polyps. Am J Rhinol Allergy. 2011 Jul-Aug;25(4):e129-32. doi: 10.2500/ajra.2011.25.3618.
389 Comparative gene expression analysis of a chronic myelogenous leukemia cell line resistant to cyclophosphamide using oligonucleotide arrays and response to tyrosine kinase inhibitors. Leuk Res. 2007 Nov;31(11):1511-20.
390 Single-cell Transcriptome Mapping Identifies Common and Cell-type Specific Genes Affected by Acute Delta9-tetrahydrocannabinol in Humans. Sci Rep. 2020 Feb 26;10(1):3450. doi: 10.1038/s41598-020-59827-1.
391 MMP-14 and TIMP-2 overexpression protects against hydroquinone-induced oxidant injury in RPE: implications for extracellular matrix turnover. Invest Ophthalmol Vis Sci. 2007 Dec;48(12):5662-70. doi: 10.1167/iovs.07-0392.
392 Resveratrol induces apoptosis and alters gene expression in human fibrosarcoma cells. Anticancer Res. 2015 Feb;35(2):767-74.
393 A transcriptomics-based in vitro assay for predicting chemical genotoxicity in vivo. Carcinogenesis. 2012 Jul;33(7):1421-9.
394 Gene expression changes in primary human nasal epithelial cells exposed to formaldehyde in vitro. Toxicol Lett. 2010 Oct 5;198(2):289-95.
395 DNA methylation inhibits p53-mediated survivin repression. Oncogene. 2009 May 14;28(19):2046-50. doi: 10.1038/onc.2009.62. Epub 2009 Apr 13.
396 Systems analysis of transcriptome and proteome in retinoic acid/arsenic trioxide-induced cell differentiation/apoptosis of promyelocytic leukemia. Proc Natl Acad Sci U S A. 2005 May 24;102(21):7653-8.
397 Distinctive profiles of gene expression in the human nucleus accumbens associated with cocaine and heroin abuse. Neuropsychopharmacology. 2006 Oct;31(10):2304-12. doi: 10.1038/sj.npp.1301089. Epub 2006 May 3.
398 Epigenetic silencing of novel tumor suppressors in malignant melanoma. Cancer Res. 2006 Dec 1;66(23):11187-93. doi: 10.1158/0008-5472.CAN-06-1274.
399 The genomic response of a human uterine endometrial adenocarcinoma cell line to 17alpha-ethynyl estradiol. Toxicol Sci. 2009 Jan;107(1):40-55.
400 Substance dependence low-density whole genome association study in two distinct American populations. Hum Genet. 2008 Jun;123(5):495-506. doi: 10.1007/s00439-008-0501-0. Epub 2008 Apr 26.
401 Application of the adverse outcome pathway concept for investigating developmental neurotoxicity potential of Chinese herbal medicines by using human neural progenitor cells in vitro. Cell Biol Toxicol. 2023 Feb;39(1):319-343. doi: 10.1007/s10565-022-09730-4. Epub 2022 Jun 15.
402 Oxidative stress-induced TET1 upregulation mediates active DNA demethylation in human gastric epithelial cells. J Toxicol Sci. 2023;48(5):273-283. doi: 10.2131/jts.48.273.
403 Role of TET Dioxygenases and DNA Hydroxymethylation in Bisphenols-Stimulated Proliferation of Breast Cancer Cells. Environ Health Perspect. 2020 Feb;128(2):27008. doi: 10.1289/EHP5862. Epub 2020 Feb 27.
404 Preferential induction of the AhR gene battery in HepaRG cells after a single or repeated exposure to heterocyclic aromatic amines. Toxicol Appl Pharmacol. 2010 Nov 15;249(1):91-100.
405 Methotrexate modulates folate phenotype and inflammatory profile in EA.hy 926 cells. Eur J Pharmacol. 2014 Jun 5;732:60-7.
406 Computational discovery of niclosamide ethanolamine, a repurposed drug candidate that reduces growth of hepatocellular carcinoma cells initro and in mice by inhibiting cell division cycle 37 signaling. Gastroenterology. 2017 Jun;152(8):2022-2036.
407 Transcriptome-based functional classifiers for direct immunotoxicity. Arch Toxicol. 2014 Mar;88(3):673-89.
408 Gene-expression profiling during curcumin-induced apoptosis reveals downregulation of CXCR4. Exp Hematol. 2007 Jan;35(1):84-95.
409 Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization. Autophagy. 2016 Nov;12(11):2213-2229. doi: 10.1080/15548627.2016.1213927. Epub 2016 Sep 16.
410 Unique transcriptome, pathways, and networks in the human endometrial fibroblast response to progesterone in endometriosis. Biol Reprod. 2011 Apr;84(4):801-15.
411 ATR inhibitors VE-821 and VX-970 sensitize cancer cells to topoisomerase i inhibitors by disabling DNA replication initiation and fork elongation responses. Cancer Res. 2014 Dec 1;74(23):6968-79.
412 Bone marrow osteoblast damage by chemotherapeutic agents. PLoS One. 2012;7(2):e30758. doi: 10.1371/journal.pone.0030758. Epub 2012 Feb 17.
413 Effect of retinoic acid on gene expression in human conjunctival epithelium: secretory phospholipase A2 mediates retinoic acid induction of MUC16. Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4050-61.
414 Monitoring of deiodinase deficiency based on transcriptomic responses in SH-SY5Y cells. Arch Toxicol. 2013 Jun;87(6):1103-13. doi: 10.1007/s00204-013-1018-4. Epub 2013 Feb 10.
415 A trichostatin A expression signature identified by TempO-Seq targeted whole transcriptome profiling. PLoS One. 2017 May 25;12(5):e0178302. doi: 10.1371/journal.pone.0178302. eCollection 2017.
416 Gene expression preferentially regulated by tamoxifen in breast cancer cells and correlations with clinical outcome. Cancer Res. 2006 Jul 15;66(14):7334-40.
417 Prediction of doxorubicin sensitivity in breast tumors based on gene expression profiles of drug-resistant cell lines correlates with patient survival. Oncogene. 2005 Nov 17;24(51):7542-51. doi: 10.1038/sj.onc.1208908.
418 Up-regulation of endothelial nitric oxide synthase (eNOS), silent mating type information regulation 2 homologue 1 (SIRT1) and autophagy-related genes by repeated treatments with resveratrol in human umbilical vein endothelial cells. Br J Nutr. 2013 Dec;110(12):2150-5.
419 Riboflavin depletion impairs cell proliferation in adult human duodenum: identification of potential effectors. Dig Dis Sci. 2011 Apr;56(4):1007-19. doi: 10.1007/s10620-010-1374-3. Epub 2010 Sep 17.
420 PPARgamma controls CD1d expression by turning on retinoic acid synthesis in developing human dendritic cells. J Exp Med. 2006 Oct 2;203(10):2351-62.
421 Peroxisome proliferator activated receptor gamma (PPAR-gama) ligand pioglitazone regulated gene networks in term human primary trophoblast cells. Reprod Toxicol. 2018 Oct;81:99-107.
422 A microarray study on the effect of four hormone therapy regimens on gene transcription in whole blood from healthy postmenopausal women. Thromb Res. 2012 Jul;130(1):45-51. doi: 10.1016/j.thromres.2011.12.009. Epub 2012 Jan 2.
423 Increased mitochondrial ROS formation by acetaminophen in human hepatic cells is associated with gene expression changes suggesting disruption of the mitochondrial electron transport chain. Toxicol Lett. 2015 Apr 16;234(2):139-50.
424 Persistent and non-persistent changes in gene expression result from long-term estrogen exposure of MCF-7 breast cancer cells. J Steroid Biochem Mol Biol. 2011 Feb;123(3-5):140-50.
425 Transcriptome dynamics of alternative splicing events revealed early phase of apoptosis induced by methylparaben in H1299 human lung carcinoma cells. Arch Toxicol. 2020 Jan;94(1):127-140. doi: 10.1007/s00204-019-02629-w. Epub 2019 Nov 20.
426 CXCL14 downregulation in human keratinocytes is a potential biomarker for a novel in vitro skin sensitization test. Toxicol Appl Pharmacol. 2020 Jan 1;386:114828. doi: 10.1016/j.taap.2019.114828. Epub 2019 Nov 14.
427 BET bromodomain inhibition as a novel strategy for reactivation of HIV-1. J Leukoc Biol. 2012 Dec;92(6):1147-54. doi: 10.1189/jlb.0312165. Epub 2012 Jul 16.
428 Developmental and tissue-specific expression of DEAD box protein p72. Neuroreport. 2000 Feb 28;11(3):457-62. doi: 10.1097/00001756-200002280-00006.
429 Effect of all-trans retinoic acid on sodium/iodide symporter expression, radioiodine uptake and gene expression profiles in a human anaplastic thyroid carcinoma cell line. Nucl Med Biol. 2006 Oct;33(7):875-82. doi: 10.1016/j.nucmedbio.2006.07.004.
430 Transcriptional profiling of MCF7 breast cancer cells in response to 5-Fluorouracil: relationship with cell cycle changes and apoptosis, and identification of novel targets of p53. Int J Cancer. 2006 Sep 1;119(5):1164-75.
431 Resveratrol enhances anti-proliferative effect of VACM-1/cul5 in T47D cancer cells. Cell Biol Toxicol. 2011 Apr;27(2):95-105. doi: 10.1007/s10565-010-9173-3. Epub 2010 Oct 15.
432 Molecular mechanisms of quercitrin-induced apoptosis in non-small cell lung cancer. Arch Med Res. 2014 Aug;45(6):445-54.
433 New insights into BaP-induced toxicity: role of major metabolites in transcriptomics and contribution to hepatocarcinogenesis. Arch Toxicol. 2016 Jun;90(6):1449-58.
434 Gene expression profiling of human primary astrocytes exposed to manganese chloride indicates selective effects on several functions of the cells. Neurotoxicology. 2007 May;28(3):478-89.
435 Antiepileptic drugs are endocrine disruptors for the human fetal testis ex vivo. Toxicol Sci. 2023 Sep 28;195(2):169-183. doi: 10.1093/toxsci/kfad076.
436 The mitochondrial superoxide/thioredoxin-2/Ask1 signaling pathway is critically involved in troglitazone-induced cell injury to human hepatocytes. Toxicol Sci. 2008 Feb;101(2):341-9. doi: 10.1093/toxsci/kfm273. Epub 2007 Nov 1.
437 Vitamin D3 up-regulated protein 1 mediates oxidative stress via suppressing the thioredoxin function. J Immunol. 2000 Jun 15;164(12):6287-95. doi: 10.4049/jimmunol.164.12.6287.
438 Efavirenz and 8-hydroxyefavirenz induce cell death via a JNK- and BimEL-dependent mechanism in primary human hepatocytes. Toxicol Appl Pharmacol. 2011 Dec 1;257(2):227-34. doi: 10.1016/j.taap.2011.09.008. Epub 2011 Sep 19.
439 Sevoflurane-mediated activation of p38-mitogen-activated stresskinase is independent of apoptosis in Jurkat T-cells. Anesth Analg. 2008 Apr;106(4):1150-60, table of contents. doi: 10.1213/ane.0b013e3181683d37.
440 Levodopa activates apoptosis signaling kinase 1 (ASK1) and promotes apoptosis in a neuronal model: implications for the treatment of Parkinson's disease. Chem Res Toxicol. 2011 Oct 17;24(10):1644-52. doi: 10.1021/tx200082h. Epub 2011 Aug 22.
441 Identification of novel gene targets and putative regulators of arsenic-associated DNA methylation in human urothelial cells and bladder cancer. Chem Res Toxicol. 2015 Jun 15;28(6):1144-55. doi: 10.1021/tx500393y. Epub 2015 Jun 3.
442 Cell-type-specific responses to chemotherapeutics in breast cancer. Cancer Res. 2004 Jun 15;64(12):4218-26.
443 Loss of TRIM33 causes resistance to BET bromodomain inhibitors through MYC- and TGF-beta-dependent mechanisms. Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):E4558-66.
444 Genome-Wide Analysis of Low Dose Bisphenol-A (BPA) Exposure in Human Prostate Cells. Curr Genomics. 2019 May;20(4):260-274. doi: 10.2174/1389202920666190603123040.
445 Berberine acts as a putative epigenetic modulator by affecting the histone code. Toxicol In Vitro. 2016 Oct;36:10-17. doi: 10.1016/j.tiv.2016.06.004. Epub 2016 Jun 13.
446 Toxicogenomics-based prediction of acetaminophen-induced liver injury using human hepatic cell systems. Toxicol Lett. 2016 Jan 5;240(1):50-9.
447 Sex hormones and gene expression signatures in peripheral blood from postmenopausal women - the NOWAC postgenome study. BMC Med Genomics. 2011 Mar 31;4:29. doi: 10.1186/1755-8794-4-29.
448 Identification of pim kinases as novel targets for PJ34 with confounding effects in PARP biology. ACS Chem Biol. 2012 Dec 21;7(12):1962-7. doi: 10.1021/cb300317y. Epub 2012 Oct 8.
449 Reproducible chemical-induced changes in gene expression profiles in human hepatoma HepaRG cells under various experimental conditions. Toxicol In Vitro. 2009 Apr;23(3):466-75. doi: 10.1016/j.tiv.2008.12.018. Epub 2008 Dec 30.
450 Oxidative stress-induced epigenetic changes associated with malignant transformation of human kidney epithelial cells. Oncotarget. 2017 Feb 14;8(7):11127-11143. doi: 10.18632/oncotarget.12091.
451 Effects of chronic exposure to arsenic and estrogen on epigenetic regulatory genes expression and epigenetic code in human prostate epithelial cells. PLoS One. 2012;7(8):e43880. doi: 10.1371/journal.pone.0043880. Epub 2012 Aug 27.
452 YM155 as an inhibitor of cancer stemness simultaneously inhibits autophosphorylation of epidermal growth factor receptor and G9a-mediated stemness in lung cancer cells. PLoS One. 2017 Aug 7;12(8):e0182149. doi: 10.1371/journal.pone.0182149. eCollection 2017.
453 Convergent transcriptional profiles induced by endogenous estrogen and distinct xenoestrogens in breast cancer cells. Carcinogenesis. 2006 Aug;27(8):1567-78.
454 Mechanisms of indomethacin-induced alterations in the choline phospholipid metabolism of breast cancer cells. Neoplasia. 2006 Sep;8(9):758-71.
455 Label-free quantitative proteomic analysis identifies the oncogenic role of FOXA1 in BaP-transformed 16HBE cells. Toxicol Appl Pharmacol. 2020 Sep 15;403:115160. doi: 10.1016/j.taap.2020.115160. Epub 2020 Jul 25.
456 Multi-level gene expression profiles affected by thymidylate synthase and 5-fluorouracil in colon cancer. BMC Genomics. 2006 Apr 3;7:68. doi: 10.1186/1471-2164-7-68.
457 Estradiol and selective estrogen receptor modulators differentially regulate target genes with estrogen receptors alpha and beta. Mol Biol Cell. 2004 Mar;15(3):1262-72. doi: 10.1091/mbc.e03-06-0360. Epub 2003 Dec 29.
458 Toxicoproteomics reveals an effect of clozapine on autophagy in human liver spheroids. Toxicol Mech Methods. 2023 Jun;33(5):401-410. doi: 10.1080/15376516.2022.2156005. Epub 2022 Dec 19.
459 Agonist and antagonist of retinoic acid receptors cause similar changes in gene expression and induce senescence-like growth arrest in MCF-7 breast carcinoma cells. Cancer Res. 2006 Sep 1;66(17):8749-61.
460 Genome-wide analysis of BEAS-2B cells exposed to trivalent arsenicals and dimethylthioarsinic acid. Toxicology. 2010 Jan 31;268(1-2):31-9.
461 Effect of aflatoxin B(1), benzo[a]pyrene, and methapyrilene on transcriptomic and epigenetic alterations in human liver HepaRG cells. Food Chem Toxicol. 2018 Nov;121:214-223. doi: 10.1016/j.fct.2018.08.034. Epub 2018 Aug 26.
462 A genomic approach to predict synergistic combinations for breast cancer treatment. Pharmacogenomics J. 2013 Feb;13(1):94-104. doi: 10.1038/tpj.2011.48. Epub 2011 Nov 15.
463 Evidence of a role for TRPC channels in VEGF-mediated increased vascular permeability in vivo. Am J Physiol Heart Circ Physiol. 2004 Mar;286(3):H1015-26. doi: 10.1152/ajpheart.00826.2003. Epub 2003 Oct 9.
464 The role of transient receptor potential channel blockers in human gastric cancer cell viability. Can J Physiol Pharmacol. 2012 Feb;90(2):175-86. doi: 10.1139/y11-114. Epub 2012 Feb 6.
465 Akt and XIAP regulate the sensitivity of human uterine cancer cells to cisplatin, doxorubicin and taxol. Apoptosis. 2008 Feb;13(2):259-71. doi: 10.1007/s10495-007-0165-6.
466 Characterization of DNA reactive and non-DNA reactive anticancer drugs by gene expression profiling. Mutat Res. 2007 Jun 1;619(1-2):16-29. doi: 10.1016/j.mrfmmm.2006.12.007. Epub 2007 Feb 8.
467 Protein expression profiling identifies molecular targets of quercetin as a major dietary flavonoid in human colon cancer cells. Proteomics. 2004 Jul;4(7):2160-74.
468 Synergistic effects of retinoic acid and tamoxifen on human breast cancer cells: proteomic characterization. Exp Cell Res. 2007 Jan 15;313(2):357-68. doi: 10.1016/j.yexcr.2006.10.016. Epub 2006 Oct 25.
469 Changes in gene expression profiles in response to selenium supplementation among individuals with arsenic-induced pre-malignant skin lesions. Toxicol Lett. 2007 Mar 8;169(2):162-76. doi: 10.1016/j.toxlet.2007.01.006. Epub 2007 Jan 19.
470 Transcriptomic Analysis of Stem Cells Treated with Moringin or Cannabidiol: Analogies and Differences in Inflammation Pathways. Int J Mol Sci. 2019 Nov 30;20(23):6039. doi: 10.3390/ijms20236039.
471 Activation of nuclear factor-kappa B pathway by simvastatin and RhoA silencing increases doxorubicin cytotoxicity in human colon cancer HT29 cells. Mol Pharmacol. 2008 Aug;74(2):476-84.
472 A peptidyl-glucosamine derivative affects IKKalpha kinase activity in human chondrocytes. Arthritis Res Ther. 2010;12(1):R18. doi: 10.1186/ar2920. Epub 2010 Jan 29.
473 Arsenic trioxide exerts antimyeloma effects by inhibiting activity in the cytoplasmic substrates of histone deacetylase 6. PLoS One. 2012;7(2):e32215. doi: 10.1371/journal.pone.0032215. Epub 2012 Feb 22.
474 Constitutive activation of IkappaB kinase alpha and NF-kappaB in prostate cancer cells is inhibited by ibuprofen. Oncogene. 1999 Dec 2;18(51):7389-94. doi: 10.1038/sj.onc.1203160.
475 Cysteine mapping in conformationally distinct kinase nucleotide binding sites: application to the design of selective covalent inhibitors. J Med Chem. 2011 Mar 10;54(5):1347-55. doi: 10.1021/jm101396q. Epub 2011 Feb 15.
476 Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival. Cancer Res. 2006 Jun 1;66(11):5542-8. doi: 10.1158/0008-5472.CAN-05-4620.
477 Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med. 2004 May 20;350(21):2129-39. doi: 10.1056/NEJMoa040938. Epub 2004 Apr 29.
478 The dual ErbB1/ErbB2 inhibitor, lapatinib (GW572016), cooperates with tamoxifen to inhibit both cell proliferation- and estrogen-dependent gene expression in antiestrogen-resistant breast cancer. Cancer Res. 2005 Jan 1;65(1):18-25.
479 A fine-needle aspirate-based vulnerability assay identifies polo-like kinase 1 as a mediator of gemcitabine resistance in pancreatic cancer. Mol Cancer Ther. 2010 Feb;9(2):311-8. doi: 10.1158/1535-7163.MCT-09-0693. Epub 2010 Jan 26.
480 Prediction of chemosensitivity using multigene analysis in head and neck squamous cell carcinoma. Oncology. 2007;73(1-2):104-11. doi: 10.1159/000120998. Epub 2008 Mar 13.
481 Ligand-dependent activation of the epidermal growth factor receptor by secondary bile acids in polarizing colon cancer cells. Surgery. 2005 Sep;138(3):415-21. doi: 10.1016/j.surg.2005.06.030.
482 Estrogen-like activity of metals in MCF-7 breast cancer cells. Endocrinology. 2003 Jun;144(6):2425-36. doi: 10.1210/en.2002-221054.
483 Cross-talk between non-genomic and genomic signalling pathways--distinct effect profiles of environmental estrogens. Toxicol Appl Pharmacol. 2010 Jun 1;245(2):160-70. doi: 10.1016/j.taap.2010.02.015. Epub 2010 Mar 4.
484 Bidirectional cross talk between ERalpha and EGFR signalling pathways regulates tamoxifen-resistant growth. Breast Cancer Res Treat. 2006 Mar;96(2):131-46. doi: 10.1007/s10549-005-9070-2. Epub 2005 Oct 27.
485 Sensitivity of human dental pulp cells to eighteen chemical agents used for endodontic treatments in dentistry. Odontology. 2013 Jan;101(1):43-51.
486 Antitumoral activity of liraglutide, a new DNMT inhibitor in breast cancer cells in vitro and in vivo. Chem Biol Interact. 2021 Nov 1;349:109641. doi: 10.1016/j.cbi.2021.109641. Epub 2021 Sep 14.
487 Estrogen receptor alpha mediates the proliferative but not the cytotoxic dose-dependent effects of two major phytoestrogens on human breast cancer cells. Mol Pharmacol. 2001 Sep;60(3):595-602.
488 Novel retinoic acid metabolism blocking agents have potent inhibitory activities on human breast cancer cells and tumour growth. Br J Cancer. 2007 Apr 23;96(8):1204-15. doi: 10.1038/sj.bjc.6603705. Epub 2007 Mar 27.
489 Prediction of the combined effects of multiple estrogenic chemicals on MCF-7 human breast cancer cells and a preliminary molecular exploration of the estrogenic proliferative effects and related gene expression. Ecotoxicol Environ Saf. 2018 Sep 30;160:1-9. doi: 10.1016/j.ecoenv.2018.05.025. Epub 2018 May 21.
490 Cannabidiol and Oxygen-Ozone Combination Induce Cytotoxicity in Human Pancreatic Ductal Adenocarcinoma Cell Lines. Cancers (Basel). 2020 Sep 27;12(10):2774. doi: 10.3390/cancers12102774.
491 Simvastatin and lovastatin inhibit breast cell invasion induced by H-Ras. Oncol Rep. 2009 May;21(5):1317-22. doi: 10.3892/or_00000357.
492 Suppression of insulin-like growth factor signalling pathway and collagen expression in keloid-derived fibroblasts by quercetin: its therapeutic potential use in the treatment and/or prevention of keloids. Br J Dermatol. 2003 Mar;148(3):544-52. doi: 10.1046/j.1365-2133.2003.05174.x.
493 Regulation of genistein-induced differentiation in human acute myeloid leukaemia cells (HL60, NB4) Protein kinase modulation and reactive oxygen species generation. Biochem Pharmacol. 2009 Feb 1;77(3):384-96. doi: 10.1016/j.bcp.2008.10.035. Epub 2008 Nov 6.
494 Hypomethylation mediated by decreased DNMTs involves in the activation of proto-oncogene MPL in TK6 cells treated with hydroquinone. Toxicol Lett. 2012 Mar 25;209(3):239-45. doi: 10.1016/j.toxlet.2011.12.020. Epub 2012 Jan 8.
495 Activation of phosphoinositide 3-kinase/PKB pathway by CB(1) and CB(2) cannabinoid receptors expressed in prostate PC-3 cells. Involvement in Raf-1 stimulation and NGF induction. Cell Signal. 2003 Sep;15(9):851-9. doi: 10.1016/s0898-6568(03)00036-6.
496 Dominant roles of the Raf/MEK/ERK pathway in cell cycle progression, prevention of apoptosis and sensitivity to chemotherapeutic drugs. Cell Cycle. 2010 Apr 15;9(8):1629-38. doi: 10.4161/cc.9.8.11487. Epub 2010 Apr 15.
497 Down-regulation of HER-2 expression in human breast cancer cell HBC-4 and ZR75-1 by nitrogen-mustard-N-oxide. Kobe J Med Sci. 2007;53(4):135-42.
498 Estrogen regulation in human breast cancer cells of new downstream gene targets involved in estrogen metabolism, cell proliferation and cell transformation. J Mol Endocrinol. 2004 Apr;32(2):397-414.
499 Epidermal growth factor receptor activity determines response of colorectal cancer cells to gefitinib alone and in combination with chemotherapy. Clin Cancer Res. 2005 Oct 15;11(20):7480-9. doi: 10.1158/1078-0432.CCR-05-0328.
500 p53-R175H mutant gains new function in regulation of doxorubicin-induced apoptosis. Int J Cancer. 2005 Apr 10;114(3):331-6. doi: 10.1002/ijc.20818.
501 Quantitative analysis of gene expression changes in response to genotoxic compounds. Toxicol In Vitro. 2017 Mar;39:15-28. doi: 10.1016/j.tiv.2016.11.004. Epub 2016 Nov 5.
502 Induction of apoptosis by cidofovir in human papillomavirus (HPV)-positive cells. Oncol Res. 2000;12(9-10):397-408. doi: 10.3727/096504001108747855.
503 Gallic acid potentiates the apoptotic effect of paclitaxel and carboplatin via overexpression of Bax and P53 on the MCF-7 human breast cancer cell line. J Biochem Mol Toxicol. 2021 Feb;35(2):e22638. doi: 10.1002/jbt.22638. Epub 2020 Oct 1.
504 Regulation of human dUTPase gene expression and p53-mediated transcriptional repression in response to oxaliplatin-induced DNA damage. Nucleic Acids Res. 2009 Jan;37(1):78-95. doi: 10.1093/nar/gkn910. Epub 2008 Nov 16.
505 Role of miRNA in the regulation of cannabidiol-mediated apoptosis in neuroblastoma cells. Oncotarget. 2019 Jan 1;10(1):45-59. doi: 10.18632/oncotarget.26534. eCollection 2019 Jan 1.
506 Nitrogen Mustard Alkylates and Cross-Links p53 in Human Keratinocytes. Chem Res Toxicol. 2022 Apr 18;35(4):636-650. doi: 10.1021/acs.chemrestox.1c00420. Epub 2022 Mar 21.
507 Dephosphorylation of ribosomal protein P0 in response to troglitazone-induced cytotoxicity. Toxicol Lett. 2006 Oct 25;166(3):189-99. doi: 10.1016/j.toxlet.2006.07.303. Epub 2006 Aug 8.
508 Synergistic effect of trichostatin A and 5-aza-2'-deoxycytidine on growth inhibition of pancreatic endocrine tumour cell lines: a proteomic study. Proteomics. 2009 Apr;9(7):1952-66. doi: 10.1002/pmic.200701089.
509 Arsenic modulates posttranslational S-nitrosylation and translational proteome in keratinocytes. ScientificWorldJournal. 2014;2014:360153.
510 Identification of estrogen-induced genes downregulated by AhR agonists in MCF-7 breast cancer cells using suppression subtractive hybridization. Gene. 2001 Jan 10;262(1-2):207-14. doi: 10.1016/s0378-1119(00)00530-8.
511 Suppression of cancer relapse and metastasis by inhibiting cancer stemness. Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):1839-44. doi: 10.1073/pnas.1424171112. Epub 2015 Jan 20.
512 A proteomic analysis of acute leukemia cells treated with 9-hydroxyoctadecadienoic acid. Lipids Health Dis. 2016 Nov 10;15(1):192. doi: 10.1186/s12944-016-0359-4.
513 Effects of the environmental estrogens bisphenol A, o,p'-DDT, p-tert-octylphenol and coumestrol on apoptosis induction, cell proliferation and the expression of estrogen sensitive molecular parameters in the human breast cancer cell line MCF-7. J Steroid Biochem Mol Biol. 2002 Jan;80(1):61-70. doi: 10.1016/s0960-0760(01)00173-x.
514 Conception and pharmacodynamic profile of drospirenone. Steroids. 2003 Nov;68(10-13):891-905. doi: 10.1016/j.steroids.2003.08.008.
515 Biological activity of all-trans-retinoic acid with and without tamoxifen and alpha-interferon 2a in breast cancer patients. Int J Oncol. 2000 Nov;17(5):991-1000. doi: 10.3892/ijo.17.5.991.
516 Estrogen-induced loss of progesterone receptor expression in normal and malignant ovarian surface epithelial cells. Oncogene. 2005 Jun 23;24(27):4388-400. doi: 10.1038/sj.onc.1208623.
517 Tibolone and its metabolites enhance tissue factor and PAI-1 expression in human endometrial stromal cells: Evidence of progestogenic effects. Steroids. 2005 Nov;70(12):840-5. doi: 10.1016/j.steroids.2005.04.010.
518 Expression of estrogen-, progesterone-, and androgen-responsive genes in MCF-7 and MDA-MB-231 cells treated with o,p'-DDT, p,p'-DDT, or endosulfan. J Biochem Mol Toxicol. 2021 Jun;35(6):1-8. doi: 10.1002/jbt.22773. Epub 2021 Mar 16.
519 Characterization of the weak estrogen receptor alpha agonistic activity of exemestane. Breast Cancer Res Treat. 2009 Aug;116(3):461-70. doi: 10.1007/s10549-008-0151-x. Epub 2008 Aug 3.
520 A comparative study of the effect of raloxifene and gosereline on uterine leiomyoma volume changes and estrogen receptor, progesterone receptor, bcl-2 and p53 expression immunohistochemically in premenopausal women. Eur J Obstet Gynecol Reprod Biol. 2007 Nov;135(1):94-103. doi: 10.1016/j.ejogrb.2006.07.042. Epub 2006 Sep 14.
521 Serum free BG-1 cell proliferation assay: a sensitive method for determining organochlorine pesticide estrogen receptor activation at the nanomolar range. Toxicol In Vitro. 2006 Apr;20(3):382-94. doi: 10.1016/j.tiv.2005.08.016. Epub 2005 Oct 19.
522 Evidence of securin-mediated resistance to gefitinib-induced apoptosis in human cancer cells. Chem Biol Interact. 2013 Apr 25;203(2):412-22. doi: 10.1016/j.cbi.2013.03.011. Epub 2013 Mar 22.
523 Cigarette smoke and asbestos activate poly-ADP-ribose polymerase in alveolar epithelial cells. J Investig Med. 2001 Jan;49(1):68-76. doi: 10.2310/6650.2001.34092.
524 Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53. Cancer Res. 2004 May 1;64(9):3022-9. doi: 10.1158/0008-5472.can-03-1880.
525 The antidepressants imipramine, clomipramine, and citalopram induce apoptosis in human acute myeloid leukemia HL-60 cells via caspase-3 activation. J Biochem Mol Toxicol. 1999;13(6):338-47. doi: 10.1002/(sici)1099-0461(1999)13:6<338::aid-jbt8>3.0.co;2-7.
526 Ciprofloxacin mediated cell growth inhibition, S/G2-M cell cycle arrest, and apoptosis in a human transitional cell carcinoma of the bladder cell line. Clin Cancer Res. 2000 Mar;6(3):891-900.
527 Investigation of molecular mechanisms underlying the antiproliferative effects of colchicine against PC3 prostate cancer cells. Toxicol In Vitro. 2021 Jun;73:105138. doi: 10.1016/j.tiv.2021.105138. Epub 2021 Mar 6.
528 Sulindac enhances adenoviral vector expressing mda-7/IL-24-mediated apoptosis in human lung cancer. Mol Cancer Ther. 2005 Feb;4(2):291-304.
529 Methotrexate induces poly(ADP-ribose) polymerase-dependent, caspase 3-independent apoptosis in subsets of proliferating CD4+ T cells. Clin Exp Immunol. 2007 May;148(2):288-95. doi: 10.1111/j.1365-2249.2007.03335.x. Epub 2007 Feb 7.
530 4.8% sevoflurane induces activation of autophagy in human neuroblastoma SH-SY5Y cells by the AMPK/mTOR signaling pathway. Neurotoxicology. 2022 May;90:256-264. doi: 10.1016/j.neuro.2022.04.008. Epub 2022 Apr 23.
531 Enhanced chemotherapeutic efficacy of docetaxel in human lung cancer cell line via GLUT1 inhibitor. J Biochem Mol Toxicol. 2023 Jun;37(6):e23348. doi: 10.1002/jbt.23348. Epub 2023 Mar 31.
532 Breast cancer cells response to the antineoplastic agents cisplatin, carboplatin, and doxorubicin at the mRNA expression levels of distinct apoptosis-related genes, including the new member, BCL2L12. Ann N Y Acad Sci. 2007 Jan;1095:35-44. doi: 10.1196/annals.1397.005.
533 Extracellular signal-regulated kinase activation and Bcl-2 downregulation mediate apoptosis after gemcitabine treatment partly via a p53-independent pathway. Eur J Pharmacol. 2004 Oct 19;502(3):169-83. doi: 10.1016/j.ejphar.2004.09.006.
534 Verapamil potentiates anti-glioblastoma efficacy of temozolomide by modulating apoptotic signaling. Toxicol In Vitro. 2018 Oct;52:306-313. doi: 10.1016/j.tiv.2018.07.001. Epub 2018 Jul 9.
535 Inhibition of caspase-dependent mitochondrial permeability transition protects airway epithelial cells against mustard-induced apoptosis. Apoptosis. 2006 Sep;11(9):1545-59. doi: 10.1007/s10495-006-8764-1.
536 Sertraline, an antidepressant, induces apoptosis in hepatic cells through the mitogen-activated protein kinase pathway. Toxicol Sci. 2014 Feb;137(2):404-15. doi: 10.1093/toxsci/kft254. Epub 2013 Nov 5.
537 -Carotene Induces Apoptosis in Human Esophageal Squamous Cell Carcinoma Cell Lines via the Cav-1/AKT/NF-B Signaling Pathway. J Biochem Mol Toxicol. 2016 Mar;30(3):148-57. doi: 10.1002/jbt.21773. Epub 2016 Jan 6.
538 Drug-induced hepatic steatosis in absence of severe mitochondrial dysfunction in HepaRG cells: proof of multiple mechanism-based toxicity. Cell Biol Toxicol. 2021 Apr;37(2):151-175. doi: 10.1007/s10565-020-09537-1. Epub 2020 Jun 14.
539 K-RAS transformation in prostate epithelial cell overcomes H2O2-induced apoptosis via upregulation of gamma-glutamyltransferase-2. Toxicol In Vitro. 2012 Apr;26(3):429-34. doi: 10.1016/j.tiv.2012.01.013. Epub 2012 Jan 17.
540 Enhanced GRP78 protein expression via the IRE1/ASK1/p38 MAPK pathway during As(2)O(3)-induced endoplasmic reticulum stress in BEAS-2B cells. Toxicology. 2021 Oct;462:152962. doi: 10.1016/j.tox.2021.152962. Epub 2021 Sep 21.
541 [Simvastatin-induced apoptosis of K562 cells is mediated by endoplasmic reticulum stress]. Yao Xue Xue Bao. 2008 Apr;43(4):371-7.
542 Chronic oxycodone induces integrated stress response in rat brain. BMC Neurosci. 2015 Sep 16;16:58. doi: 10.1186/s12868-015-0197-8.
543 Involvement of the activation of Nrf2/HO-1, p38 MAPK signaling pathways and endoplasmic reticulum stress in furazolidone induced cytotoxicity and S phase arrest in human hepatocyte L02 cells: modulation of curcumin. Toxicol Mech Methods. 2017 Mar;27(3):165-172. doi: 10.1080/15376516.2016.1273424. Epub 2017 Jan 8.
544 p16-Cdk4-Rb axis controls sensitivity to a cyclin-dependent kinase inhibitor PD0332991 in glioblastoma xenograft cells. Neuro Oncol. 2012 Jul;14(7):870-81. doi: 10.1093/neuonc/nos114. Epub 2012 Jun 18.
545 JNK1 is required for sulindac-mediated inhibition of cell proliferation and induction of apoptosis in vitro and in vivo. Eur J Pharmacol. 2007 Apr 10;560(2-3):95-100. doi: 10.1016/j.ejphar.2007.01.020. Epub 2007 Jan 19.
546 Simvastatin inhibits cell growth and induces apoptosis and G0/G1 cell cycle arrest in hepatic cancer cells. Int J Mol Med. 2010 Nov;26(5):735-41. doi: 10.3892/ijmm_00000520.
547 A gene signature-based approach identifies thioridazine as an inhibitor of phosphatidylinositol-3'-kinase (PI3K)/AKT pathway in ovarian cancer cells. Gynecol Oncol. 2011 Jan;120(1):121-7. doi: 10.1016/j.ygyno.2010.10.003. Epub 2010 Oct 29.
548 Beta-carotene and apocarotenals promote retinoid signaling in BEAS-2B human bronchioepithelial cells. Arch Biochem Biophys. 2006 Nov 1;455(1):48-60.
549 Manganese superoxide dismutase induces migration and invasion of tongue squamous cell carcinoma via H2O2-dependent Snail signaling. Free Radic Biol Med. 2012 Jul 1;53(1):44-50. doi: 10.1016/j.freeradbiomed.2012.04.031. Epub 2012 May 9.
550 Nitric oxide causes anoikis through attenuation of E-cadherin and activation of caspase-3 in human gastric carcinoma AZ-521 cells infected with Mycoplasma hyorhinis. J Vet Med Sci. 2010 Jul;72(7):869-74.
551 Induced differentiation in HT29, a human colon adenocarcinoma cell line. J Cell Sci. 1999 Aug;112 ( Pt 16):2657-66. doi: 10.1242/jcs.112.16.2657.
552 Troglitazone increases expression of E-cadherin and claudin 4 in human pancreatic cancer cells. Biochem Biophys Res Commun. 2009 Mar 13;380(3):614-9. doi: 10.1016/j.bbrc.2009.01.134. Epub 2009 Jan 27.
553 Regulation of epithelial cell morphology and functions approaching to more in vivo-like by modifying polyethylene glycol on polysulfone membranes. PLoS One. 2012;7(4):e36110.
554 Glucosamine-induced endoplasmic reticulum stress promotes ApoB100 degradation: evidence for Grp78-mediated targeting to proteasomal degradation. Arterioscler Thromb Vasc Biol. 2005 Mar;25(3):571-7. doi: 10.1161/01.ATV.0000154142.61859.94. Epub 2004 Dec 23.
555 The nonsteroidal anti-inflammatory drugs aspirin and indomethacin attenuate beta-catenin/TCF-4 signaling. Oncogene. 2001 Feb 1;20(5):645-53. doi: 10.1038/sj.onc.1204123.
556 Novel mechanism of cannabidiol-induced apoptosis in breast cancer cell lines. Breast. 2018 Oct;41:34-41. doi: 10.1016/j.breast.2018.06.009. Epub 2018 Jun 22.
557 BMN 673 (talazoparib): A potent PARP inhibitor for triple negative breast cancer with different genetic profile. J Biochem Mol Toxicol. 2019 May;33(5):e22286. doi: 10.1002/jbt.22286. Epub 2019 Jan 23.
558 Resveratrol attenuates senescence of adipose-derived mesenchymal stem cells and restores their paracrine effects on promoting insulin secretion of INS-1 cells through Pim-1. Eur Rev Med Pharmacol Sci. 2016;20(6):1203-13.
559 Ribavirin augments doxorubicin's efficacy in human hepatocellular carcinoma through inhibiting doxorubicin-induced eIF4E activation. J Biochem Mol Toxicol. 2018 Jan;32(1). doi: 10.1002/jbt.22007. Epub 2017 Nov 7.
560 Cell cycle effects of nonsteroidal anti-inflammatory drugs and enhanced growth inhibition in combination with gemcitabine in pancreatic carcinoma cells. J Pharmacol Exp Ther. 2001 Sep;298(3):976-85.
561 Treatment with anticancer agents induces dysregulation of specific Wnt signaling pathways in human ovarian luteinized granulosa cells in vitro. Toxicol Sci. 2013 Nov;136(1):183-92. doi: 10.1093/toxsci/kft175. Epub 2013 Aug 16.
562 Progesterone increases csk homologous kinase in HMC-1560 human mast cells and reduces cell proliferation. J Cell Biochem. 2007 Dec 1;102(5):1271-80. doi: 10.1002/jcb.21357.
563 Cannabidiol upregulates melanogenesis through CB1 dependent pathway by activating p38 MAPK and p42/44 MAPK. Chem Biol Interact. 2017 Aug 1;273:107-114. doi: 10.1016/j.cbi.2017.06.005. Epub 2017 Jun 7.
564 Growth stimulation of human pulmonary adenocarcinoma cells and small airway epithelial cells by beta-carotene via activation of cAMP, PKA, CREB and ERK1/2. Int J Cancer. 2006 Mar 15;118(6):1370-80. doi: 10.1002/ijc.21537.
565 Estrogen and pure antiestrogen fulvestrant (ICI 182 780) augment cell-matrigel adhesion of MCF-7 breast cancer cells through a novel G protein coupled estrogen receptor (GPR30)-to-calpain signaling axis. Toxicol Appl Pharmacol. 2014 Mar 1;275(2):176-81. doi: 10.1016/j.taap.2014.01.005. Epub 2014 Jan 17.
566 Inhibition of activator protein 1 by barbiturates is mediated by differential effects on mitogen-activated protein kinases and the small G proteins ras and rac-1. J Pharmacol Exp Ther. 2004 Dec;311(3):1232-40. doi: 10.1124/jpet.104.071332. Epub 2004 Jul 19.
567 Growth of hormone-dependent MCF-7 breast cancer cells is promoted by constitutive caveolin-1 whose expression is lost in an EGF-R-mediated manner during development of tamoxifen resistance. Breast Cancer Res Treat. 2010 Feb;119(3):575-91. doi: 10.1007/s10549-009-0355-8. Epub 2009 Mar 15.
568 Effect of histamine H1 receptor antagonists on TARC/CCL17 and MDC/CCL22 production from CD14+ cells induced by antigenic stimulation in vitro. Int Arch Allergy Immunol. 2011;155(1):38-51. doi: 10.1159/000318720. Epub 2010 Nov 25.
569 SIRT3 Mediates the Antioxidant Effect of Hydrogen Sulfide in Endothelial Cells. Antioxid Redox Signal. 2016 Feb 20;24(6):329-43. doi: 10.1089/ars.2015.6331. Epub 2015 Nov 10.
570 Downregulation of mitogen-activated protein kinases (MAPKs) in chronic ethanol-induced fatty liver. Toxicol Mech Methods. 2020 Jul;30(6):407-416. doi: 10.1080/15376516.2020.1747126. Epub 2020 Apr 1.
571 A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling. Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16657-62. doi: 10.1073/pnas.0707936104. Epub 2007 Oct 9.
572 The stent-eluting drugs sirolimus and paclitaxel suppress healing of the endothelium by induction of autophagy. Am J Pathol. 2009 Nov;175(5):2226-34.
573 Modulation of apoptosis in HaCaT keratinocytes via differential regulation of ERK signaling pathway by flavonoids. J Biol Chem. 2005 Sep 9;280(36):31498-507. doi: 10.1074/jbc.M505537200. Epub 2005 Jul 13.
574 Inhibition of cholesterol metabolism underlies synergy between mTOR pathway inhibition and chloroquine in bladder cancer cells. Oncogene. 2016 Aug 25;35(34):4518-28. doi: 10.1038/onc.2015.511. Epub 2016 Feb 8.
575 Nicotine-induced survival signaling in lung cancer cells is dependent on their p53 status while its down-regulation by curcumin is independent. Mol Cancer. 2010 Aug 20;9:220.
576 Dihydromyricetin suppresses tumor growth via downregulation of the EGFR/Akt/survivin signaling pathway. J Biochem Mol Toxicol. 2023 Jun;37(6):e23328. doi: 10.1002/jbt.23328. Epub 2023 Feb 19.
577 Oxidative stress induces parallel autophagy and mitochondria dysfunction in human glioma U251 cells. Toxicol Sci. 2009 Aug;110(2):376-88. doi: 10.1093/toxsci/kfp101. Epub 2009 May 18.
578 Effect of toll-like receptor 7 and 9 targeted therapy to prevent the development of hepatocellular carcinoma. Liver Int. 2015 Mar;35(3):1063-76. doi: 10.1111/liv.12626. Epub 2014 Jul 30.
579 Low-expressional IGF1 mediated methimazole-induced liver developmental toxicity in fetal mice. Toxicology. 2018 Sep 1;408:70-79. doi: 10.1016/j.tox.2018.07.004. Epub 2018 Jul 7.
580 Oxidative stress modulates expression of immune checkpoint genes via activation of AhR signaling. Toxicol Appl Pharmacol. 2022 Dec 15;457:116314. doi: 10.1016/j.taap.2022.116314. Epub 2022 Nov 9.
581 Profiling of enantiopure drugs towards aryl hydrocarbon (AhR), glucocorticoid (GR) and pregnane X (PXR) receptors in human reporter cell lines. Chem Biol Interact. 2014 Feb 5;208:64-76. doi: 10.1016/j.cbi.2013.11.018. Epub 2013 Dec 6.
582 Involvement of cytoskeleton in AhR-dependent CYP1A1 expression. Curr Drug Metab. 2006 Apr;7(3):301-13. doi: 10.2174/138920006776359310.
583 Sulindac and its metabolites induce carcinogen metabolizing enzymes in human colon cancer cells. Int J Cancer. 2008 Mar 1;122(5):990-8.
584 Quercetin, quercetin glycosides and taxifolin differ in their ability to induce AhR activation and CYP1A1 expression in HepG2 cells. Phytother Res. 2012 Nov;26(11):1746-52.
585 Omeprazole inhibits pancreatic cancer cell invasion through a nongenomic aryl hydrocarbon receptor pathway. Chem Res Toxicol. 2015 May 18;28(5):907-18.
586 Expression and inducibility of cytochrome P450s (CYP1A1, 2B6, 2E1, 3A4) in human cord blood CD34(+) stem cell-derived differentiating neuronal cells. Toxicol Sci. 2012 Oct;129(2):392-410.
587 Induction of paraoxonase 1 and apolipoprotein A-I gene expression by aspirin. J Lipid Res. 2008 Oct;49(10):2142-8.
588 trans-Resveratrol inhibits H2O2-induced adenocarcinoma gastric cells proliferation via inactivation of MEK1/2-ERK1/2-c-Jun signalling axis. Biochem Pharmacol. 2009 Feb 1;77(3):337-47. doi: 10.1016/j.bcp.2008.10.034. Epub 2008 Nov 6.
589 Apoptosis induced by arsenic trioxide in leukemia U937 cells is dependent on activation of p38, inactivation of ERK and the Ca2+-dependent production of superoxide. Int J Cancer. 2001 May 15;92(4):518-26. doi: 10.1002/ijc.1220.
590 Cannabis-induced cytotoxicity in leukemic cell lines: the role of the cannabinoid receptors and the MAPK pathway. Blood. 2005 Feb 1;105(3):1214-21. doi: 10.1182/blood-2004-03-1182. Epub 2004 Sep 28.
591 Different apoptosis ratios and gene expressions in two human cell lines after sevoflurane anaesthesia. Acta Anaesthesiol Scand. 2009 Oct;53(9):1192-9. doi: 10.1111/j.1399-6576.2009.02036.x. Epub 2009 Jun 30.
592 [Mechanisms underlying the effect of arsenic trioxide on proliferation inhibition and apoptosis induction in myeloma cell line u266]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2007 Oct;15(5):982-5.
593 Lovastatin lactone elicits human lung cancer cell apoptosis via a COX-2/PPAR-dependent pathway. Oncotarget. 2016 Mar 1;7(9):10345-62. doi: 10.18632/oncotarget.7213.
594 Comparison of burst of reactive oxygen species and activation of caspase-3 in apoptosis of K562 and HL-60 cells induced by docetaxel. Cancer Lett. 2004 Oct 8;214(1):103-13. doi: 10.1016/j.canlet.2004.03.047.
595 Induction of mitochondrial manganese superoxide dismutase confers resistance to apoptosis in acute myeloblastic leukaemia cells exposed to etoposide. Br J Haematol. 2000 Mar;108(3):574-81. doi: 10.1046/j.1365-2141.2000.01852.x.
596 Cisplatin-enhanced sensitivity of glioblastoma multiforme U251 cells to adenovirus-delivered TRAIL in vitro. Tumour Biol. 2010 Dec;31(6):613-22. doi: 10.1007/s13277-010-0077-x. Epub 2010 Jul 11.
597 Insulin-like growth factor I is the key growth factor in serum that protects neuroblastoma cells from hyperosmotic-induced apoptosis. J Cell Physiol. 2000 Jan;182(1):24-32. doi: 10.1002/(SICI)1097-4652(200001)182:1<24::AID-JCP3>3.0.CO;2-6.
598 mRNA expression analysis of a variety of apoptosis-related genes, including the novel gene of the BCL2-family, BCL2L12, in HL-60 leukemia cells after treatment with carboplatin and doxorubicin. Biol Chem. 2004 Nov;385(11):1099-103. doi: 10.1515/BC.2004.143.
599 Neurokinin-1 receptor (NK1R) inhibition sensitizes APL cells to anti-tumor effect of arsenic trioxide via restriction of NF-B axis: Shedding new light on resistance to Aprepitant. Int J Biochem Cell Biol. 2018 Oct;103:105-114. doi: 10.1016/j.biocel.2018.08.010. Epub 2018 Aug 23.
600 Cannabidiol Effectively Promoted Cell Death in Bladder Cancer and the Improved Intravesical Adhesion Drugs Delivery Strategy Could Be Better Used for Treatment. Pharmaceutics. 2021 Sep 7;13(9):1415. doi: 10.3390/pharmaceutics13091415.
601 A model to identify novel targets involved in oxidative stress-induced apoptosis in human lung epithelial cells by RNA interference. Toxicol In Vitro. 2010 Feb;24(1):310-8. doi: 10.1016/j.tiv.2009.08.008. Epub 2009 Aug 23.
602 Nitric oxide inhibits execution of apoptosis at two distinct ATP-dependent steps upstream and downstream of mitochondrial cytochrome c release. Biochem Biophys Res Commun. 1999 Apr 29;258(1):215-21. doi: 10.1006/bbrc.1999.0491.
603 Palmitate increases the susceptibility of cells to drug-induced toxicity: an in vitro method to identify drugs with potential contraindications in patients with metabolic disease. Toxicol Sci. 2012 Oct;129(2):346-62. doi: 10.1093/toxsci/kfs208. Epub 2012 Jun 14.
604 Response rate of fibrosarcoma cells to cytotoxic drugs on the expression level correlates to the therapeutic response rate of fibrosarcomas and is mediated by regulation of apoptotic pathways. BMC Cancer. 2005 Jul 7;5:74. doi: 10.1186/1471-2407-5-74.
605 Simvastatin induces apoptosis and alters cytoskeleton in endometrial stromal cells. J Clin Endocrinol Metab. 2010 Jul;95(7):3453-9. doi: 10.1210/jc.2010-0072. Epub 2010 Apr 28.
606 The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib. Toxicol Sci. 2023 Dec 21;197(1):69-78. doi: 10.1093/toxsci/kfad099.
607 Differential protein expression of peroxiredoxin I and II by benzo(a)pyrene and quercetin treatment in 22Rv1 and PrEC prostate cell lines. Toxicol Appl Pharmacol. 2007 Apr 15;220(2):197-210. doi: 10.1016/j.taap.2006.12.030. Epub 2007 Jan 9.
608 Inhibition of fatty acid synthase expression by 1alpha,25-dihydroxyvitamin D3 in prostate cancer cells. J Steroid Biochem Mol Biol. 2003 May;85(1):1-8. doi: 10.1016/s0960-0760(03)00142-0.
609 Proteomic analysis of anti-cancer effects by paclitaxel treatment in cervical cancer cells. Gynecol Oncol. 2005 Jul;98(1):45-53. doi: 10.1016/j.ygyno.2005.04.010.
610 Inhibition of phosphatidylinostol 3-kinase uncouples H2O2-induced senescent phenotype and cell cycle arrest in normal human diploid fibroblasts. Exp Cell Res. 2004 Aug 1;298(1):188-96. doi: 10.1016/j.yexcr.2004.04.012.
611 Combination of all-trans retinoic acid and paclitaxel-induced differentiation and apoptosis in human glioblastoma U87MG xenografts in nude mice. Cancer. 2008 Feb 1;112(3):596-607. doi: 10.1002/cncr.23223.
612 Characterization of cell death induced by ethacrynic acid in a human colon cancer cell line DLD-1 and suppression by N-acetyl-L-cysteine. Cancer Sci. 2003 Oct;94(10):886-93.
613 Cleavage of focal adhesion kinase is an early marker and modulator of oxidative stress-induced apoptosis. Chem Biol Interact. 2008 Jan 10;171(1):57-66. doi: 10.1016/j.cbi.2007.08.009. Epub 2007 Aug 19.
614 Quercetin inhibits migration and invasion of SAS human oral cancer cells through inhibition of NF-B and matrix metalloproteinase-2/-9 signaling pathways. Anticancer Res. 2013 May;33(5):1941-50.
615 Activation of cannabinoid receptors promote periodontal cell adhesion and migration. J Clin Periodontol. 2019 Dec;46(12):1264-1272. doi: 10.1111/jcpe.13190. Epub 2019 Oct 22.
616 Monomeric and oligomeric flavanols are agonists of membrane androgen receptors. Exp Cell Res. 2005 Oct 1;309(2):329-39. doi: 10.1016/j.yexcr.2005.06.011.
617 Disruption of FAK signaling: a side mechanism in cytotoxicity. Toxicology. 2008 Mar 12;245(1-2):1-10. doi: 10.1016/j.tox.2007.12.003. Epub 2007 Dec 15.
618 Comparison of the effects of metoclopramide and domperidone on HERG channels. Pharmacology. 2005 Apr;74(1):31-6. doi: 10.1159/000083234. Epub 2005 Jan 7.
619 Further insights into the effect of quinidine in short QT syndrome caused by a mutation in HERG. J Cardiovasc Electrophysiol. 2005 Jan;16(1):54-8. doi: 10.1046/j.1540-8167.2005.04470.x.
620 Automated tight seal electrophysiology for assessing the potential hERG liability of pharmaceutical compounds. Assay Drug Dev Technol. 2004 Oct;2(5):497-506. doi: 10.1089/adt.2004.2.497.
621 Refining the human iPSC-cardiomyocyte arrhythmic risk assessment model. Toxicol Sci. 2013 Dec;136(2):581-94. doi: 10.1093/toxsci/kft205. Epub 2013 Sep 19.
622 Pharmacology of the short QT syndrome N588K-hERG K+ channel mutation: differential impact on selected class I and class III antiarrhythmic drugs. Br J Pharmacol. 2008 Nov;155(6):957-66. doi: 10.1038/bjp.2008.325. Epub 2008 Aug 25.
623 Comparison of HERG channel blocking effects of various beta-blockers-- implication for clinical strategy. Br J Pharmacol. 2006 Mar;147(6):642-52. doi: 10.1038/sj.bjp.0706508.
624 Inhibitory effects of the class III antiarrhythmic drug amiodarone on cloned HERG potassium channels. Naunyn Schmiedebergs Arch Pharmacol. 1999 Mar;359(3):212-9. doi: 10.1007/pl00005344.
625 Redox state dependency of HERGS631C channel pharmacology: relation to C-type inactivation. FEBS Lett. 2000 May 26;474(1):111-5. doi: 10.1016/s0014-5793(00)01586-6.
626 Cannabidiol disrupts apoptosis, autophagy and invasion processes of placental trophoblasts. Arch Toxicol. 2021 Oct;95(10):3393-3406. doi: 10.1007/s00204-021-03122-z. Epub 2021 Jul 24.
627 AMP-activated protein kinase activity is required for vanadate-induced hypoxia-inducible factor 1alpha expression in DU145 cells. Carcinogenesis. 2004 Dec;25(12):2497-507. doi: 10.1093/carcin/bgh253. Epub 2004 Aug 5.
628 Identification of chemical compounds that induce HIF-1alpha activity. Toxicol Sci. 2009 Nov;112(1):153-63.
629 NO-sulindac inhibits the hypoxia response of PC-3 prostate cancer cells via the Akt signalling pathway. Int J Cancer. 2009 Jan 1;124(1):223-32. doi: 10.1002/ijc.23934.
630 Simvastatin stimulates vascular endothelial growth factor production by hypoxia-inducible factor-1alpha upregulation in endothelial cells. J Cardiovasc Pharmacol. 2008 Mar;51(3):267-73. doi: 10.1097/FJC.0b013e3181624b44.
631 Epinephrine facilitates the growth of T cell lymphoma by altering cell proliferation, apoptosis, and glucose metabolism. Chem Biol Interact. 2023 Jan 5;369:110278. doi: 10.1016/j.cbi.2022.110278. Epub 2022 Nov 22.
632 Multifaceted preventive effects of single agent quercetin on a human prostate adenocarcinoma cell line (PC-3): implications for nutritional transcriptomics and multi-target therapy. Med Oncol. 2011 Dec;28(4):1395-404. doi: 10.1007/s12032-010-9603-3. Epub 2010 Jul 2.
633 Screening autism-associated environmental factors in differentiating human neural progenitors with fractional factorial design-based transcriptomics. Sci Rep. 2023 Jun 29;13(1):10519. doi: 10.1038/s41598-023-37488-0.
634 SU5416 inhibited VEGF and HIF-1alpha expression through the PI3K/AKT/p70S6K1 signaling pathway. Biochem Biophys Res Commun. 2004 Nov 12;324(2):471-80. doi: 10.1016/j.bbrc.2004.09.082.
635 Expression of the retinoic acid-metabolizing enzyme CYP26A1 limits programmed cell death. Mol Pharmacol. 2005 May;67(5):1808-17. doi: 10.1124/mol.104.005769. Epub 2005 Feb 9.
636 Role of BAX in the apoptotic response to anticancer agents. Science. 2000 Nov 3;290(5493):989-92. doi: 10.1126/science.290.5493.989.
637 Simvastatin induces apoptosis in human colon cancer cells and in tumor xenografts, and attenuates colitis-associated colon cancer in mice. Int J Cancer. 2008 Aug 15;123(4):951-7. doi: 10.1002/ijc.23593.
638 Cannabidiol induces antioxidant pathways in keratinocytes by targeting BACH1. Redox Biol. 2020 Jan;28:101321. doi: 10.1016/j.redox.2019.101321. Epub 2019 Sep 5.
639 Enhanced cytotoxicity of bioreductive antitumor agents with dimethyl fumarate in human glioblastoma cells. Anticancer Drugs. 2005 Feb;16(2):167-74.
640 Growth-suppressive effect of non-steroidal anti-inflammatory drugs on 11 colon-cancer cell lines and fluorescence differential display of genes whose expression is influenced by sulindac. Int J Cancer. 2000 Dec 15;88(6):873-80. doi: 10.1002/1097-0215(20001215)88:6<873::aid-ijc6>3.0.co;2-b.
641 Simvastatin protects dopaminergic neurons against MPP+-induced oxidative stress and regulates the endogenous anti-oxidant system through ERK. Cell Physiol Biochem. 2018;51(4):1957-1968.
642 P450 3A-catalyzed O-dealkylation of lapatinib induces mitochondrial stress and activates Nrf2. Chem Res Toxicol. 2016 May 16;29(5):784-96.
643 Induction of human NAD(P)H:quinone oxidoreductase (NQO1) gene expression by the flavonol quercetin. Toxicol Lett. 2001 Feb 3;119(1):49-57.