Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMSOX7I)

• Drug Name: Cocaine Drug Info
• Synonyms: Allococaine; Allopseudococaine; Badrock; Bazooka; Benzoylethylecgonine; Benzoylmethylecgonine; Bernice; Bernies; Blast; Blizzard; Blow; Burese; COC; Cabello; Candy; Carrie; Caviar; Cecil; Charlie; Cholly; Coca; Cocain; Cocaina; Cocainum; Cocktail; Coke; Cola; Corine; Crack; Eritroxilina; Erytroxylin; Flake; Flex; Freeze; Girl; Goofball; Heaven; Hell; Jam; Kokain; Kokan; Kokayeen; Lady; Leaf; Moonrocks; Neurocaine; Pseudoallococaine; Rock; Sleighride; Snort; Snow; Toke; Toot; Trails; Yeyo; Bernice [Street Name]; Blow [Street Name]; Bouncing Powder; Cecil [Street Name]; Chicken Scratch; Cocaine [BAN]; Cocaine free base; Cocaine solution; Crack cocaine; Dama blanca; Ecgonine methyl ester benzoate; Ecgonine methyl ester benzoate solution; Flake [Street Name]; Florida Snow; Foo Foo; Girl [Street Name]; Gold dust; Gold dust [Street Name]; Green gold; Happy dust; Happy dust [Street Name]; Happy powder; Happy trails; Lady [Street Name]; Methyl Benzoylecgonine; Nose candy; Prime Time; Rock [Street Name]; Sweet Stuff; Toot [Street Name]; White girl or lady; Beta-Cocain; C" Carrie; Cocaine (TN); Cocaine (USP); Cocaine-M; G-Rock; Kibbles n' Bits; L-Cocain; L-Cocaine; Pimp's drug; Snow (birds); Star-spangled powder; Ecgonine, methyl ester, benzoate (ester); Methyl 3beta-hydroxy-1alphaH,5alphaH-tropane-2beta-carboxylate benzoate (ester); Methyl 3-benzoyloxy-8-methyl-8-azabicyclo[3.2.1]octane-4-carboxylate; Methyl 3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate; Methyl (3S,4R)-3-benzoyloxy-8-methyl-8-azabicyclo[3.2.1]octane-4-carboxylate; Methyl (1S,4R,5R)-3-benzoyloxy-8-methyl-8-azabicyclo[3.2.1]octane-4-carboxylate; (-)-Cocaine; (-)-Cocaine base; (1R,2R,3S,5S)-2-(methoxycarbonyl)tropan-3-yl benzoate; (1R,2R,3S,5S)-2-Methoxycarbonyltropan-3-yl benzoate; (R)-Cocaine; 1-Cocaine; 2-beta-Carbomethoxy-3-beta-benzoxytropane; 2-beta-Tropanecarboxylic acid, 3-beta-hydroxy-, methyl ester, benzoate (ester); 2beta-Carbomethoxy-3beta-benzoxytropane; 3-Tropanylbenzoate-2-carboxylic acid methyl ester; 3beta-Hydroxy-2beta-tropanecarboxylic acid methyl ester benzoate (ester)

Indication

Disease Entry	ICD 11	Status	REF
Anaesthesia	9A78.6	Approved	[1]
Cocaine addiction	6C45.2	Approved	[2]

• Therapeutic Class: Anesthetics
• Cross-matching ID:
  PubChem CID: 446220
  ChEBI ID: CHEBI:27958
  CAS Number: CAS 50-36-2
  TTD Drug ID: DMSOX7I
  VARIDT Drug ID: DR00530
  INTEDE Drug ID: DR0365

Molecule-Related Drug Atlas

Drug(s) Targeting Norepinephrine transporter (NET)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[15]
Amitriptyline	DMK7F9S	Depression	6A70-6A7Z	Approved	[16]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[17]
Desipramine	DMT2FDC	Attention deficit hyperactivity disorder	6A05.Z	Approved	[15]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[18]
Tapentadol hydrochloride	DMXLSH3	Acute pain	MG31	Approved	[19]
Venlafaxine	DMR6QH0	Anxiety disorder	6B00-6B0Z	Approved	[18]
Trimipramine	DM1SC8M	Major depressive disorder	6A70.3	Approved	[20]
Duloxetine	DM9BI7M	Depression	6A70-6A7Z	Approved	[21]
Levomilnacipran	DMV26S8	Fibromyalgia	MG30.01	Approved	[22]

Drug(s) Targeting Serotonin transporter (SERT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[15]
Amitriptyline	DMK7F9S	Depression	6A70-6A7Z	Approved	[16]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[23]
Vortioxetine	DM6F1PU	Major depressive disorder	6A70.3	Approved	[24]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[25]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[18]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[23]
Nortriptyline	DM4KDYJ	Depression	6A70-6A7Z	Approved	[23]
Trazodone	DMK1GBJ	Depression	6A70-6A7Z	Approved	[23]
Paroxetine	DM5PVQE	Anxiety disorder	6B00-6B0Z	Approved	[23]

Drug(s) Targeting Dopamine transporter (DAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dasotraline	DMLDQFV	Attention deficit hyperactivity disorder	6A05.Z	Approved	[26]
Methylphenidate	DM7SJD6	Attention deficit hyperactivity disorder	6A05.Z	Approved	[27]
Modafinil	DMYILBE	Malignant glioma	2A00.0	Approved	[23]
Phenmetrazine	DMXYTN9	Obesity	5B81	Approved	[28]
Ioflupane i-123	DMNARJT	Parkinson disease	8A00.0	Approved	[29]
DEXMETHYLPHENIDATE HYDROCHLORIDE	DM8WBAH	Attention deficit hyperactivity disorder	6A05.Z	Approved	[30]
Altropane	DMO9WDS	Attention deficit hyperactivity disorder	6A05.Z	Approved	[31]
Amitifadine	DMS1X67	Obesity	5B81	Phase 3	[32]
NAV5001	DMRSI1M	Dementia	6D80-6D86	Phase 3	[31]
MIN-117	DMSLIW6	Major depressive disorder	6A70.3	Phase 2	[33]

Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[34]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[35]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[36]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[37]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[38]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[39]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[40]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[41]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[35]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[42]

Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[43]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[44]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[45]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[38]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[42]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[46]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[47]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[48]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[49]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[50]

Drug(s) Metabolized By Cytochrome P450 3A5 (CYP3A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[51]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[52]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[53]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[7]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[54]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[55]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[56]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[57]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[58]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[7]

Drug(s) Metabolized By Cytochrome P450 3A7 (CYP3A7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[59]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[7]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[7]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[7]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[4]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[60]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[7]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[7]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[7]
Metronidazole	DMTIVEN	Abscess		Approved	[61]

Drug(s) Affected By Cholinesterase (BCHE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[62]
Galantamine	DMEO794	Alzheimer disease	8A20	Approved	[63]
Rivastigmine	DMG629M	Alzheimer disease	8A20	Approved	[64]
Donepezil	DMIYG7Z	Advanced cancer	2A00-2F9Z	Approved	[14]
Succinylcholine	DM2ET1M	Plasma cell myeloma	2A83.1	Approved	[65]
Ethopropazine	DM0N3L7	Parkinson disease	8A00.0	Approved	[62]
Dimenhydrinate	DM264B3	Meniere disease	AB31.0	Approved	[66]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[67]
Chlorpheniramine	DM5URA2	Allergic rhinitis	CA08.0	Approved	[66]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[68]

Drug(s) Affected By Alanine aminotransferase 1 (GPT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Halothane	DM80OZ5	Anaesthesia	9A78.6	Approved	[14]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[69]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[70]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[14]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[14]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[71]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[71]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[71]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[73]

Drug(s) Affected By Cocaine esterase (CES2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[74]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[75]
Dextropropoxyphene	DM23HCX	Pain	MG30-MG3Z	Approved	[76]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[77]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[79]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[82]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[83]

Drug(s) Affected By Cytoplasmic dynein 1 intermediate chain 1 (DYNC1I1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[84]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[87]
Bortezomib	DMNO38U	Leukemia		Approved	[88]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[89]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[90]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[91]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[92]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[93]

Drug(s) Affected By Septin-4 (SEPTIN4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[13]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[96]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[99]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[100]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[101]

Drug(s) Affected By LIM domain-binding protein 2 (LDB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[102]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[103]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[90]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[84]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[91]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[104]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[92]

Drug(s) Affected By Phospholipid phosphatase 2 (PLPP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[106]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[108]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[109]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[110]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[111]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[91]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[112]

Drug(s) Affected By Superoxide dismutase (SOD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[113]
Haloperidol	DM96SE0	Delirium		Approved	[14]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[114]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[115]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[116]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[117]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[118]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[119]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[120]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[121]

Drug(s) Affected By Protein kinase C beta type (PRKCB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[104]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[122]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[124]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[84]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[125]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[126]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[122]

Drug(s) Affected By Gelsolin (GSN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Selenium	DM25CGV	N. A.	N. A.	Approved	[104]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[129]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[130]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[124]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[131]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[131]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]

Drug(s) Affected By Neurofilament light polypeptide (NEFL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[133]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[84]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[134]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[135]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[102]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[87]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[133]

Drug(s) Affected By Neurofilament medium polypeptide (NEFM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[137]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[138]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[139]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[84]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[141]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[102]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[142]
Lidocaine	DML4ZOT	Anaesthesia	9A78.6	Approved	[143]

Drug(s) Affected By Profilin-1 (PFN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[144]
Selenium	DM25CGV	N. A.	N. A.	Approved	[104]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[145]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[147]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[148]
Haloperidol	DM96SE0	Delirium		Approved	[149]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[150]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]

Drug(s) Affected By Cytochrome c1, heme protein, mitochondrial (CYC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[152]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[153]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[155]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[156]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[90]

Drug(s) Affected By Small ribosomal subunit protein uS2 (RPSA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[144]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[157]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[158]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[159]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[160]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[161]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[162]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[163]

Drug(s) Affected By Fibroblast growth factor 2 (FGF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[164]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[137]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[165]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[166]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[167]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[168]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Isradipine	DMA5XGH	Hypertension	BA00-BA04	Approved	[169]
Valdecoxib	DMAY7H4	Osteoarthritis	FA00-FA05	Approved	[170]

Drug(s) Affected By Gamma-enolase (ENO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[104]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[171]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[172]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[173]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[174]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[127]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[175]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[175]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]

Drug(s) Affected By Guanine nucleotide-binding protein G(o) subunit alpha (GNAO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[106]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[155]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[100]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[91]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[92]
UNC0379	DMD1E4J	Hepatocellular carcinoma	2C12.02	Preclinical	[177]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[178]

Drug(s) Affected By Clathrin light chain B (CLTB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[104]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[129]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[124]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[179]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[89]

Drug(s) Affected By Cytochrome c oxidase subunit 6C (COX6C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[180]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[181]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[182]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[183]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[184]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[185]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[90]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[92]

Drug(s) Affected By Cadherin-1 (CDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[114]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[186]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[187]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[188]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[189]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[190]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[191]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[84]

Drug(s) Affected By Fos-related antigen 1 (FOSL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[192]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[193]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[194]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[195]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[196]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[197]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[198]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[127]

Drug(s) Affected By Neuroendocrine convertase 2 (PCSK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[199]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[199]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[91]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[101]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[92]
4-hydroxy-2-nonenal	DM2LJFZ	Discovery agent	N.A.	Investigative	[200]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[138]

Drug(s) Affected By Neuromodulin (GAP43)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[201]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[201]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[202]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[84]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Methazolamide	DM7J2TA	Glaucoma/ocular hypertension	9C61	Approved	[201]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[135]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[203]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Megestrol	DMDH9KX	Breast cancer	2C60-2C65	Approved	[201]

Drug(s) Affected By Receptor-type tyrosine-protein phosphatase alpha (PTPRA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]
Mecamylamine	DMGQFYB	Essential hypertension	BA00	Approved	[204]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[128]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[101]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[204]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[205]

Drug(s) Affected By Pleiotrophin (PTN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[206]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[207]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[208]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[90]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[84]
Chondroitin sulfate	DM0N19Y	N. A.	N. A.	Phase 4	[209]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[210]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[211]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[212]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[213]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[214]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[215]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[216]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[217]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[218]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[219]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[220]

Drug(s) Affected By Gap junction beta-2 protein (GJB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[221]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[131]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[107]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[102]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[87]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[103]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[100]

Drug(s) Affected By Malate dehydrogenase, cytoplasmic (MDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[144]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[223]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[224]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[225]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[150]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[149]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[149]

Drug(s) Affected By Vesicle-fusing ATPase (NSF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[106]
Haloperidol	DM96SE0	Delirium		Approved	[149]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[149]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[149]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[226]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[227]

Drug(s) Affected By Microtubule-associated protein 1B (MAP1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[228]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[68]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[197]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[127]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[229]

Drug(s) Affected By F-actin-capping protein subunit beta (CAPZB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[104]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[230]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[231]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[87]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[90]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[232]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[104]

Drug(s) Affected By G protein-activated inward rectifier potassium channel 2 (KCNJ6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[92]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[138]

Drug(s) Affected By ATP synthase F(0) complex subunit C3, mitochondrial (ATP5MC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[233]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[225]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[198]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[234]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[235]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[90]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[236]

Drug(s) Affected By Caspase-4 (CASP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[206]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[237]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[115]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[238]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[239]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[240]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[106]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[241]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[135]

Drug(s) Affected By Translocon-associated protein subunit delta (SSR4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[87]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[104]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[236]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[178]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[242]

Drug(s) Affected By Neuronal membrane glycoprotein M6-a (GPM6A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[243]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[244]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[91]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[84]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[92]
PMID28870136-Compound-48	DMPIM9L	N. A.	N. A.	Patented	[245]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[246]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[247]

Drug(s) Affected By Mitogen-activated protein kinase 10 (MAPK10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[84]
Sorbitol	DMAN0DE	Constipation	DD91.1	Approved	[248]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[249]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[250]
Dicumarol	DMFQCB1	Bleeding disorder	GA20-GA21	Approved	[248]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[153]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[102]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[251]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[248]

Drug(s) Affected By Ataxin-3 (ATXN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[252]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[253]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[90]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[254]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[104]

Drug(s) Affected By Myelin proteolipid protein (PLP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[84]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[247]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[250]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[255]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[255]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[244]

Drug(s) Affected By Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PPP1CA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[256]
Selenium	DM25CGV	N. A.	N. A.	Approved	[104]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[257]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[87]
Amiloride	DMRTSGP	Congestive heart failure	BD10	Approved	[258]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[90]
Aminoglutethimide	DMWFHMZ	Cushing disease	5A70	Approved	[259]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[260]

Drug(s) Affected By Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (PPP2CB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[261]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[77]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[224]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[68]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[262]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[234]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[261]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[155]

Drug(s) Affected By Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (GNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[263]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[264]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[155]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[90]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[101]
Bupivacaine	DM4PRFC	Anaesthesia	9A78.6	Approved	[14]

Drug(s) Affected By Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PPP2CA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[265]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[266]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[267]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[268]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[269]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[270]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[271]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[227]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[272]

Drug(s) Affected By Vacuolar fusion protein CCZ1 homolog B (CCZ1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[273]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[87]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[90]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[92]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[274]

Drug(s) Affected By Interferon regulatory factor 9 (IRF9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[104]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[124]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[147]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[82]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[275]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[207]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[253]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[87]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]

Drug(s) Affected By Transcription factor AP-4 (TFAP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[131]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[131]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[87]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[227]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[100]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[205]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[276]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[277]

Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 1 (MAP2K1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[278]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[279]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[280]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[281]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[282]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[283]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[262]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[153]

Drug(s) Affected By Focal adhesion kinase 1 (PTK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[216]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[284]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[221]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[285]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[286]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[287]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[288]
Halothane	DM80OZ5	Anaesthesia	9A78.6	Approved	[289]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]

Drug(s) Affected By Paired box protein Pax-8 (PAX8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[139]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[290]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[291]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[292]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[293]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[294]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[260]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[205]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[295]

Drug(s) Affected By Cadherin-17 (CDH17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[111]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[296]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[297]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[92]

Drug(s) Affected By Neuronal membrane glycoprotein M6-b (GPM6B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[298]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[298]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[87]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[298]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[299]

Drug(s) Affected By Hepatic sodium/bile acid cotransporter (SLC10A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[300]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[301]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[302]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[303]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[193]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[304]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[305]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[306]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]

Drug(s) Affected By Beta-sarcoglycan (SGCB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[286]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[227]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[260]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[78]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[307]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[308]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[247]

Drug(s) Affected By Hypoxia-inducible factor 1-alpha (HIF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[309]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[310]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[311]
Triamterene	DM2HU9I	Congestive heart failure	BD10	Approved	[311]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[312]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[313]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[314]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[315]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[316]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[317]

Drug(s) Affected By Rho GTPase-activating protein 29 (ARHGAP29)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[221]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[274]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[318]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[127]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[229]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]

Drug(s) Affected By Glutamate decarboxylase 1 (GAD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[77]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[319]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[84]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[127]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Isoflurophate	DMBSK7X	Glaucoma/ocular hypertension	9C61	Approved	[320]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[321]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[322]

Drug(s) Affected By Transgelin-3 (TAGLN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[225]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[262]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[87]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[97]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[323]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[205]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[84]

Drug(s) Affected By Catenin delta-2 (CTNND2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[84]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[227]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[324]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[91]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[84]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[185]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[92]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[138]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[325]

Drug(s) Affected By Type 2 lactosamine alpha-2,3-sialyltransferase (ST3GAL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[138]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[135]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[127]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[128]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[326]

Drug(s) Affected By Glucocorticoid receptor (NR3C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[327]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[328]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Selenium	DM25CGV	N. A.	N. A.	Approved	[104]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[329]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[330]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[331]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[332]

Drug(s) Affected By Cytochrome P450 2C8 (CYP2C8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[333]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[334]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[333]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[334]
Sulfinpyrazone	DMEV954	Gout	FA25	Approved	[335]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[333]
Zafirlukast	DMHNQOG	Asthma	CA23	Approved	[333]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[333]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[336]
Dabrafenib	DMX6OE3	Melanoma	2C30	Approved	[337]

Drug(s) Affected By Cytochrome P450 2C9 (CYP2C9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[338]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[339]
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[340]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[341]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[342]
Zafirlukast	DMHNQOG	Asthma	CA23	Approved	[343]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[340]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[344]
Fluconazole	DMOWZ6B	Cryptococcal meningitis		Approved	[341]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[340]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 3 (NR1I3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[345]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[346]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[130]
Artemether	DM48QOT	Malaria	1F40-1F45	Approved	[347]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[348]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[193]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[349]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[350]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[351]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]

Drug(s) Affected By Endothelin-1 receptor (EDNRA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[138]
Selenium	DM25CGV	N. A.	N. A.	Approved	[104]
Fructose	DM43AN2	Vomiting	MD90	Approved	[352]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[84]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[87]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[99]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[353]

Drug(s) Affected By Nitric oxide synthase 3 (NOS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[354]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[355]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[14]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[356]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[77]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[357]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[358]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[359]
Fructose	DM43AN2	Vomiting	MD90	Approved	[360]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[361]

Drug(s) Affected By Chloride intracellular channel protein 1 (CLIC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[362]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[127]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[150]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[363]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[155]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[103]

Drug(s) Affected By Krev interaction trapped protein 1 (KRIT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[262]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[364]
Bortezomib	DMNO38U	Leukemia		Approved	[88]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[226]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[103]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[365]
taurine	DMVW7N3	Discovery agent	N.A.	Investigative	[366]

Drug(s) Affected By Integrin beta-1-binding protein 1 (ITGB1BP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[262]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[207]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[13]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[367]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[368]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[369]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[260]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[260]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[370]

Drug(s) Affected By 5-hydroxymethyl-dUMP N-hydrolase (DNPH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[262]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[13]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[371]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[87]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[372]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]

Drug(s) Affected By Oligophrenin-1 (OPHN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[131]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[131]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[87]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[373]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[226]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[292]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[90]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[92]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[374]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[375]

Drug(s) Affected By Liprin-alpha-3 (PPFIA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[376]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[155]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[232]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[92]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[274]

Drug(s) Affected By NADH dehydrogenase iron-sulfur protein 2, mitochondrial (NDUFS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[90]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[233]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[234]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[128]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[377]

Drug(s) Affected By Pituitary homeobox 3 (PITX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[91]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[205]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[92]
PHENCYCLIDINE	DMQBEYX	Discovery agent	N.A.	Investigative	[378]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[379]

Drug(s) Affected By Deformed epidermal autoregulatory factor 1 homolog (DEAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[262]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[13]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[87]
Bortezomib	DMNO38U	Leukemia		Approved	[88]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[90]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[93]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[274]

Drug(s) Affected By Claudin-11 (CLDN11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[107]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[262]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[380]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[381]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[382]
Tetracycline	DMZA017	Acne vulgaris	ED80	Approved	[383]

Drug(s) Affected By TIP41-like protein (TIPRL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[256]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[82]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[384]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[138]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[375]
CH-223191	DMMJZYC	Solid tumour/cancer	2A00-2F9Z	Investigative	[385]

Drug(s) Affected By Protocadherin-8 (PCDH8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[84]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[373]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[324]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[90]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[91]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[84]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[84]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[386]

Drug(s) Affected By NADH dehydrogenase 1 alpha subcomplex subunit 10, mitochondrial (NDUFA10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[138]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[387]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[234]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[381]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[227]

Drug(s) Affected By Apoptosis-inducing factor 1, mitochondrial (AIFM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[138]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[256]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[388]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[389]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[238]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[225]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[390]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[391]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[241]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]

Drug(s) Affected By Reversion-inducing cysteine-rich protein with Kazal motifs (RECK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[104]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[197]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[262]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[392]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[364]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[142]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[393]

Drug(s) Affected By Epidermal growth factor receptor (EGFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BIBW 2992	DMTKD7Q	Non-small-cell lung cancer	2C25.Y	Approved	[394]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[395]
Erlotinib	DMCMBHA	Adrenal gland neoplasm		Approved	[396]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[397]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[398]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[399]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[237]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[256]
Selenium	DM25CGV	N. A.	N. A.	Approved	[400]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[401]

Drug(s) Affected By Adenylate kinase isoenzyme 1 (AK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[14]
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[14]
Anastrozole	DMNP60F	Breast cancer	2C60-2C65	Approved	[14]
Aminoglutethimide	DMWFHMZ	Cushing disease	5A70	Approved	[14]
Selenium	DM25CGV	N. A.	N. A.	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[149]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[149]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[87]

Drug(s) Affected By Protein c-Fos (FOS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[68]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[137]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[402]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[237]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[402]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[403]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[404]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[405]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[406]

Drug(s) Affected By Beta-nerve growth factor (NGF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[407]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[330]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[408]
MCI-186	DM8ZHP1	Amyotrophic lateral sclerosis	8B60.0	Approved	[409]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[135]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[410]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[411]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[87]
Lidocaine	DML4ZOT	Anaesthesia	9A78.6	Approved	[143]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[412]

Drug(s) Affected By Natriuretic peptides A (NPPA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[413]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[414]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[415]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[416]
Cilazapril	DM4V6JA	Congestive heart failure	BD10	Approved	[417]
Lisinopril	DMUOK4C	Chronic heart failure	BD1Z	Approved	[418]
Irbesartan	DMTP1DC	Diabetic kidney disease	GB61.Z	Approved	[419]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[420]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[421]

Drug(s) Affected By Pro-opiomelanocortin (POMC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[422]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[423]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[424]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[425]
Fentanyl	DM8WAHT	Analgesia	MB40.8	Approved	[426]
Cyproheptadine	DM92AH3	Allergic rhinitis	CA08.0	Approved	[427]
Triamcinolone	DM98IXF	Acute adrenal insufficiency		Approved	[428]
Buspirone	DMBS632	Anxiety disorder	6B00-6B0Z	Approved	[429]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[430]
Metyrapone	DMI7FVQ	Cushing disease	5A70	Approved	[431]

Drug(s) Affected By Proenkephalin-A (PENK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[430]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Amphetamine	DMSZQAK	Attention deficit hyperactivity disorder	6A05.Z	Approved	[432]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[101]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[111]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[91]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[92]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[247]

Drug(s) Affected By Proenkephalin-B (PDYN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[84]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[13]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[430]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[373]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[97]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[292]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[90]

Drug(s) Affected By Lutropin subunit beta (LHB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[433]
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[434]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[435]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[436]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[437]
Alprazolam	DMC7XDN	Anxiety		Approved	[438]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Norethindrone acetate	DMDGCQP	N. A.	N. A.	Approved	[434]
Metoclopramide	DMFA5MY	Nausea	MD90	Approved	[436]
Cetrorelix	DMFD9Q6	Ovarian stimulation	LB45.1	Approved	[439]

Drug(s) Affected By Prolactin (PRL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[440]
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[441]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[442]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[443]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[330]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[444]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[445]
Aripiprazole	DM3NUMH	Bipolar I disorder		Approved	[446]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[447]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[448]

Drug(s) Affected By Insulin (INS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[449]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[330]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[450]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[451]
Fructose	DM43AN2	Vomiting	MD90	Approved	[452]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[171]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[453]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[454]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[455]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[456]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[457]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[458]
Fructose	DM43AN2	Vomiting	MD90	Approved	[14]
Ketoprofen	DMRKXPT	Bursitis		Approved	[14]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[459]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[214]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[460]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[461]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[462]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[463]

Drug(s) Affected By Interferon gamma (IFNG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[464]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[465]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[466]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[467]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[330]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[468]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[469]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[470]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[471]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[472]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[206]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[473]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[474]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[475]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[116]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[475]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[476]
Selenium	DM25CGV	N. A.	N. A.	Approved	[477]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[478]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[479]

Drug(s) Affected By Alpha-crystallin B chain (CRYAB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[144]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[480]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[481]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[182]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[131]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[131]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[264]

Drug(s) Affected By Myelin basic protein (MBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[330]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[482]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[106]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[247]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[483]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[484]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[380]

Drug(s) Affected By C-reactive protein (CRP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lidocaine	DML4ZOT	Anaesthesia	9A78.6	Approved	[14]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[485]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[486]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[487]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[224]
Acalabrutinib	DM7GCVW	leukaemia	2A60-2B33	Approved	[488]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[489]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[490]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[491]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[106]

Drug(s) Affected By Serum amyloid P-component (APCS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[302]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Valsartan	DMREUQ6	Chronic heart failure	BD1Z	Approved	[492]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[493]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[155]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[99]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[81]
Ardeparin	DMYRX8B	Deep vein thrombosis	BD71	Approved	[494]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[92]

Drug(s) Affected By Platelet basic protein (PPBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[495]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[496]
Nortriptyline	DM4KDYJ	Depression	6A70-6A7Z	Approved	[497]
Paroxetine	DM5PVQE	Anxiety disorder	6B00-6B0Z	Approved	[497]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[498]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[499]
Amlodipine	DMBDAZV	Angina pectoris	BA40	Approved	[500]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[102]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[501]

Drug(s) Affected By Platelet factor 4 (PF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[495]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[502]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[330]
Fructose	DM43AN2	Vomiting	MD90	Approved	[352]
Nortriptyline	DM4KDYJ	Depression	6A70-6A7Z	Approved	[497]
Paroxetine	DM5PVQE	Anxiety disorder	6B00-6B0Z	Approved	[497]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[273]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[503]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[90]
Ardeparin	DMYRX8B	Deep vein thrombosis	BD71	Approved	[504]

Drug(s) Affected By C-X-C motif chemokine 10 (CXCL10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[465]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[505]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[480]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[506]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[507]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[158]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[508]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]

Drug(s) Affected By Transferrin receptor protein 1 (TFRC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[115]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[509]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[510]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[223]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[318]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[511]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[225]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[512]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[513]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[514]

Drug(s) Affected By Serotransferrin (TF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[515]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[516]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Isoflurophate	DMBSK7X	Glaucoma/ocular hypertension	9C61	Approved	[517]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[101]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[264]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[518]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[519]

Drug(s) Affected By Amyloid-beta precursor protein (APP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Selenium	DM25CGV	N. A.	N. A.	Approved	[104]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[330]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[520]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[331]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[521]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[522]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[523]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[68]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[524]

Drug(s) Affected By Inhibin alpha chain (INHA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[331]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[227]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[525]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[90]
Testosterone undecanoate	DMZO10Y	Hypogonadism	5A61.0	Approved	[526]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[205]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[527]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[527]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[527]

Drug(s) Affected By Interleukin-5 (IL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[465]
Tolnaftate	DM28MU7	Dermatophytosis	1F28.2	Approved	[528]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[529]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[530]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[531]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[532]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[533]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[534]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[535]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[536]

Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[298]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[537]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[538]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[539]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[540]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[473]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[463]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[476]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[541]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[298]

Drug(s) Affected By Endothelin-1 (EDN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[542]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[543]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[129]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[544]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[545]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[124]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[546]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[547]
Lisinopril	DMUOK4C	Chronic heart failure	BD1Z	Approved	[548]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[549]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[550]
Fructose	DM43AN2	Vomiting	MD90	Approved	[14]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[551]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[552]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[237]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[115]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[553]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[554]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[555]

Drug(s) Affected By ATP synthase subunit beta, mitochondrial (ATP5F1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[556]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[145]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[557]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[558]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[249]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[231]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[558]

Drug(s) Affected By Laminin subunit beta-1 (LAMB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[256]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[559]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[102]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[142]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[560]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[155]

Drug(s) Affected By Calmodulin-1 (CALM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Selenium	DM25CGV	N. A.	N. A.	Approved	[104]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[561]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[129]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[561]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[562]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[127]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[563]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[564]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[565]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[539]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[552]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[473]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[475]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[116]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[566]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[475]

Drug(s) Affected By C-C motif chemokine 3 (CCL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[540]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[330]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[480]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[567]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[498]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[568]
Betamethasone	DMAHJEF	Acute adrenal insufficiency		Approved	[569]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[569]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[540]

Drug(s) Affected By 60 kDa heat shock protein, mitochondrial (HSPD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[570]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[145]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[77]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[123]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[480]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[571]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[572]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[225]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[512]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[573]

Drug(s) Affected By Endoplasmic reticulum chaperone BiP (HSPA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[574]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[575]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[576]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[145]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[577]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[578]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[579]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[580]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[581]

Drug(s) Affected By Serine/threonine-protein kinase pim-1 (PIM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[473]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[582]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[77]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[124]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[84]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[194]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[68]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[197]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[583]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[127]

Drug(s) Affected By Angiotensin-converting enzyme (ACE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Trandolapril	DM4L6EU	Chronic heart failure	BD1Z	Approved	[14]
Fosinopril	DM9NJ52	Chronic heart failure	BD1Z	Approved	[14]
Quinapril	DMR8H31	Chronic heart failure	BD1Z	Approved	[14]
Cilazapril	DM4V6JA	Congestive heart failure	BD10	Approved	[584]
Perindopril	DMOPZDT	Hypertension	BA00-BA04	Approved	[585]
Lisinopril	DMUOK4C	Chronic heart failure	BD1Z	Approved	[586]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[106]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[587]
Cenestin	DMXQS7K	Menopause symptom	GA30.0	Approved	[588]

Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[540]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[328]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[589]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[463]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[590]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[591]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[592]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[330]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[593]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[505]

Drug(s) Affected By Glial fibrillary acidic protein (GFAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Penicillin V	DMKVOYF	Acute otitis media	AB00	Approved	[14]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[14]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[594]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[482]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[595]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[106]
Haloperidol	DM96SE0	Delirium		Approved	[149]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[231]

Drug(s) Affected By D(2) dopamine receptor (DRD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Droperidol	DM0DXA8	Nausea	MD90	Approved	[14]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[14]
Zuclopenthixol	DMKYD5N	Schizophrenia	6A20	Approved	[14]
Meglitinides	DM1OFHN	Type-2 diabetes	5A11	Approved	[596]
Sulpiride	DMF54ZG	Schizophrenia	6A20	Approved	[597]
Risperidone	DMN6DXL	Bipolar I disorder		Approved	[598]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[599]
Methamphetamine	DMPM4SK	Anxiety		Approved	[600]
Bromocriptine	DMVE3TK	Acromegaly	5A60.0	Approved	[601]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[602]

Drug(s) Affected By Ezrin (EZR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[149]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Selenium	DM25CGV	N. A.	N. A.	Approved	[104]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[129]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[84]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[603]
Haloperidol	DM96SE0	Delirium		Approved	[149]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[127]

Drug(s) Affected By Fos-related antigen 2 (FOSL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[198]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[135]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[127]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[175]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[175]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[262]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]

Drug(s) Affected By Desmoplakin (DSP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[257]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[152]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[107]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[127]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[150]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[90]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[255]

Drug(s) Affected By CD44 antigen (CD44)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[206]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[604]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Selenium	DM25CGV	N. A.	N. A.	Approved	[605]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[606]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[607]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[124]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[608]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[84]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[609]

Drug(s) Affected By P-selectin (SELP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[496]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[610]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[611]
Amlodipine	DMBDAZV	Angina pectoris	BA40	Approved	[500]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Asasantin	DMCZIHT	Cerebrovascular ischaemia	8B1Z	Approved	[612]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[613]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[614]
Ardeparin	DMYRX8B	Deep vein thrombosis	BD71	Approved	[615]

Drug(s) Affected By Transcription factor JunB (JUNB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[552]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[328]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[224]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[68]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[152]
Nilotinib	DM7HXWT	Chronic myelogenous leukaemia	2A20.0	Approved	[616]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[617]

Drug(s) Affected By Transcription factor JunD (JUND)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[552]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[237]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[561]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[286]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[512]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[193]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[243]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[603]

Drug(s) Affected By Integrin beta-6 (ITGB6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[131]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[131]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[108]
Bortezomib	DMNO38U	Leukemia		Approved	[88]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[299]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[618]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]

Drug(s) Affected By Troponin I, cardiac muscle (TNNI3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[547]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[561]
Perphenazine	DMA4MRX	Schizophrenia	6A20	Approved	[619]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[620]
Methamphetamine	DMPM4SK	Anxiety		Approved	[621]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[99]

Drug(s) Affected By Cyclin-A2 (CCNA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[278]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[622]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[403]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[261]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[623]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[624]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[625]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[221]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[626]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]

Drug(s) Affected By Parvalbumin alpha (PVALB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[92]

Drug(s) Affected By Interleukin-10 (IL10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[627]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[465]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[529]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[628]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[629]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[630]
Bisoprolol	DM3UZ95	Hypertension	BA00-BA04	Approved	[631]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[470]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[632]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[507]

Drug(s) Affected By Nucleoside diphosphate kinase B (NME2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[145]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[106]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[633]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[634]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[635]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[145]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[372]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[636]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[637]

Drug(s) Affected By Receptor-type tyrosine-protein phosphatase beta (PTPRB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[225]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[127]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[638]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[276]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[138]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[247]
Nickel chloride	DMI12Y8	Discovery agent	N.A.	Investigative	[639]

Drug(s) Affected By Sodium-dependent noradrenaline transporter (SLC6A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amphetamine	DMSZQAK	Attention deficit hyperactivity disorder	6A05.Z	Approved	[640]
Norepinephrine	DMOUC09	Alopecia	ED70	Approved	[641]
Selenium	DM25CGV	N. A.	N. A.	Approved	[104]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[642]
Dextroamphetamine	DMMIHVP	Attention deficit hyperactivity disorder	6A05.Z	Approved	[643]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[294]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[91]
Nortriptyline	DM4KDYJ	Depression	6A70-6A7Z	Approved	[644]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[112]

Drug(s) Affected By Nuclear transcription factor Y subunit beta (NFYB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[124]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[103]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[645]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[369]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[124]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[645]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[93]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[114]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[261]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[388]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[646]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[647]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[315]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[648]
Fructose	DM43AN2	Vomiting	MD90	Approved	[352]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[649]

Drug(s) Affected By ATP synthase subunit alpha, mitochondrial (ATP5F1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[149]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[650]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[557]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[651]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[652]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[653]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[150]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[234]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[380]

Drug(s) Affected By Elongation factor 1-gamma (EEF1G)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[145]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[654]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[153]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[87]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[155]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[655]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[90]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[294]

Drug(s) Affected By CCN family member 2 (CCN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[538]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[328]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[192]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[302]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[481]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[298]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[609]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[197]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[499]

Drug(s) Affected By Transketolase (TKT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[104]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[300]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[654]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[225]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[197]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[262]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[637]

Drug(s) Affected By Peroxiredoxin-5, mitochondrial (PRDX5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[90]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[656]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[182]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[262]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[153]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[87]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[657]

Drug(s) Affected By Phosphatidylethanolamine-binding protein 1 (PEBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[658]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[233]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[149]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[149]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[183]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[90]

Drug(s) Affected By CAP-Gly domain-containing linker protein 1 (CLIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[659]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[660]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[128]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[103]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[661]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[662]

Drug(s) Affected By Sodium-dependent serotonin transporter (SLC6A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paroxetine	DM5PVQE	Anxiety disorder	6B00-6B0Z	Approved	[663]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[664]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[665]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[666]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[667]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Aripiprazole	DM3NUMH	Bipolar I disorder		Approved	[668]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[666]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[262]

Drug(s) Affected By Peroxiredoxin-2 (PRDX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[669]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[145]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[670]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[331]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[225]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[671]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[672]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]

Drug(s) Affected By Gastrin/cholecystokinin type B receptor (CCKBR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[84]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[673]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[84]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[244]
Paricalcitol	DMYBV3G	Hyperparathyroidism	5A51	Approved	[14]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[84]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[84]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[92]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[673]

Drug(s) Affected By D(3) dopamine receptor (DRD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Haloperidol	DM96SE0	Delirium		Approved	[674]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[675]
Risperidone	DMN6DXL	Bipolar I disorder		Approved	[676]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[364]
Methamphetamine	DMPM4SK	Anxiety		Approved	[677]
Droperidol	DM0DXA8	Nausea	MD90	Approved	[14]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[14]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[14]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[14]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[14]

Drug(s) Affected By Alpha-actinin-2 (ACTN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[678]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[13]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[227]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[90]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[91]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[92]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[93]

Drug(s) Affected By Hippocalcin-like protein 1 (HPCAL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[104]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[654]
Desloratadine	DM56YN7	Allergic rhinitis	CA08.0	Approved	[679]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[68]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[653]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[560]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]

Drug(s) Affected By Squalene synthase (FDFT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[680]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[316]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[225]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[127]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[681]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[249]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]

Drug(s) Affected By Alpha-synuclein (SNCA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[68]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[376]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[87]
Bortezomib	DMNO38U	Leukemia		Approved	[682]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[683]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[97]

Drug(s) Affected By Glutamate receptor 2 (GRIA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[104]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[684]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[685]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[244]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[104]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[686]
UNC0379	DMD1E4J	Hepatocellular carcinoma	2C12.02	Preclinical	[177]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[138]

Drug(s) Affected By Glutamate receptor 3 (GRIA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[687]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[228]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[138]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[84]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[688]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[273]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[99]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[101]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[91]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[689]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[690]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[691]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[692]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[693]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[694]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[695]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[696]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[697]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[698]

Drug(s) Affected By Beta-crystallin B2 (CRYBB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[99]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[92]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[699]

Drug(s) Affected By Nuclear receptor subfamily 4 group A member 2 (NR4A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[700]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[321]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[197]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[701]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[685]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[101]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[253]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[87]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[702]

Drug(s) Affected By Small ribosomal subunit protein uS4 (RPS9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[257]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[671]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[150]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[153]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[88]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[185]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[92]

Drug(s) Affected By Small ribosomal subunit protein eS10 (RPS10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[703]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[96]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[155]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[274]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[380]
Z-Pro-Prolinal	DM43O2U	Discovery agent	N.A.	Investigative	[704]
AHPN	DM8G6O4	Discovery agent	N.A.	Investigative	[705]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[242]

Drug(s) Affected By Protein Tob1 (TOB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[138]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[256]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[561]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[127]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[207]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[88]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[706]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[87]

Drug(s) Affected By C-C chemokine receptor type 5 (CCR5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[707]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[708]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[709]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[645]
I3C	DMIGFOR	Breast cancer	2C60-2C65	Phase 3	[710]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[711]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[712]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[645]
EUGENOL	DM7US1H	Discovery agent	N.A.	Patented	[708]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[253]

Drug(s) Affected By Protein FosB (FOSB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[499]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[124]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[225]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[147]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[701]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[152]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[318]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[273]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[713]

Drug(s) Affected By AP-2 complex subunit sigma (AP2S1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[262]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[163]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[155]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[104]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[92]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[93]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[325]

Drug(s) Affected By Ephrin type-B receptor 4 (EPHB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[315]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[262]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[82]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[714]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[87]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]
Omacetaxine mepesuccinate	DMPU2WX	Adult acute monocytic leukemia		Approved	[715]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[155]

Drug(s) Affected By GTP-binding protein GEM (GEM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[256]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[330]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[152]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[617]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[247]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[253]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[102]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[87]

Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[716]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[717]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[538]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[718]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[719]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[720]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[388]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[721]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[722]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[723]

Drug(s) Affected By C-X-C chemokine receptor type 4 (CXCR4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[114]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[298]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[315]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[724]
Carfilzomib	DM48K0X	Multiple myeloma	2A83	Approved	[725]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[298]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[266]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[726]

Drug(s) Affected By Eukaryotic translation initiation factor 5A-1 (EIF5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[145]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[257]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[13]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]
Bortezomib	DMNO38U	Leukemia		Approved	[88]
Morphine	DMRMS0L	Advanced cancer	2A00-2F9Z	Approved	[727]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[227]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[673]

Drug(s) Affected By Actin, gamma-enteric smooth muscle (ACTG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[654]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[654]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[131]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[131]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[127]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[262]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[102]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[142]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[87]

Drug(s) Affected By Glutathione S-transferase omega-1 (GSTO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[124]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[603]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[153]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[87]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[160]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[728]

Drug(s) Affected By Spectrin beta chain, non-erythrocytic 1 (SPTBN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[257]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[127]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[262]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[249]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[153]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[380]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[373]

Drug(s) Affected By Glutamate receptor ionotropic, NMDA 1 (GRIN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[666]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[666]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[729]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[666]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[106]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[666]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[730]
Sulfadiazine	DMTW3R8	Rheumatic fever	1B40-1B42	Approved	[666]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[666]

Drug(s) Affected By Synaptic vesicular amine transporter (SLC18A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Norepinephrine	DMOUC09	Alopecia	ED70	Approved	[731]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[731]
Methamphetamine	DMPM4SK	Anxiety		Approved	[732]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[733]
Haloperidol	DM96SE0	Delirium		Approved	[733]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Dextroamphetamine	DMMIHVP	Attention deficit hyperactivity disorder	6A05.Z	Approved	[733]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[734]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[292]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[735]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[698]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[538]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[736]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[114]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[719]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[737]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[738]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[739]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase D (PPID)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[129]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[262]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[364]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[155]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[103]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[101]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[740]

Drug(s) Affected By Semaphorin-3B (SEMA3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[138]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Selenium	DM25CGV	N. A.	N. A.	Approved	[104]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[129]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[741]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[742]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[227]

Drug(s) Affected By Dystrophin-related protein 2 (DRP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[225]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[90]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[205]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[276]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[92]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[93]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[743]

Drug(s) Affected By Calcium/calmodulin-dependent protein kinase type II subunit beta (CAMK2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[574]
Selenium	DM25CGV	N. A.	N. A.	Approved	[104]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[106]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[241]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[155]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[744]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[90]

Drug(s) Affected By Cullin-4B (CUL4B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[380]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[745]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[103]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[746]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[81]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[93]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[274]

Drug(s) Affected By Endoplasmic reticulum membrane sensor NFE2L1 (NFE2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[561]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[636]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[745]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[747]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[99]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[748]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[90]

Drug(s) Affected By Myocyte-specific enhancer factor 2D (MEF2D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[152]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[127]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[376]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[87]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[292]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[90]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[205]

Drug(s) Affected By Proteasome activator complex subunit 4 (PSME4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[570]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[253]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[381]

Drug(s) Affected By Cysteine and glycine-rich protein 2 (CSRP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[498]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[197]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[127]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[102]

Drug(s) Affected By Cocaine- and amphetamine-regulated transcript protein (CARTPT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[645]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[255]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[101]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[92]

Drug(s) Affected By BDNF/NT-3 growth factors receptor (NTRK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[463]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[749]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[225]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[671]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[13]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[102]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[683]

Drug(s) Affected By Prolyl endopeptidase-like (PREPL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[553]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[225]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[13]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[364]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[381]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[155]

Drug(s) Affected By Myomegalin (PDE4DIP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[654]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[84]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[243]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[13]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[750]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[464]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[155]

Drug(s) Affected By Adropin (ENHO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[13]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[297]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[92]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[365]
ORG2058	DMH1M6N	Discovery agent	N.A.	Investigative	[751]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[752]

Drug(s) Affected By Liprin-beta-1 (PPFIBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[104]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[77]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[753]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[135]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[175]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[175]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[175]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[175]

Drug(s) Affected By Tumor protein p53-inducible nuclear protein 2 (TP53INP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[152]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[131]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[131]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[754]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[302]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[87]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[755]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[103]

Drug(s) Affected By RING1 and YY1-binding protein (RYBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Selenium	DM25CGV	N. A.	N. A.	Approved	[104]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[127]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[745]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[103]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[90]

Drug(s) Affected By Programmed cell death protein 7 (PDCD7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[330]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[756]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[756]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[277]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[757]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[93]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[756]

Drug(s) Affected By Neuropilin and tolloid-like protein 2 (NETO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[758]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[758]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[182]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[262]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[87]
Bortezomib	DMNO38U	Leukemia		Approved	[88]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[227]

Drug(s) Affected By Scavenger receptor class B member 1 (SCARB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[759]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[760]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[761]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[224]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[762]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[763]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[764]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[249]

Drug(s) Affected By Protein Churchill (CHURC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[13]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[205]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[92]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[93]
methyl p-hydroxybenzoate	DMO58UW	Discovery agent	N.A.	Investigative	[765]

Drug(s) Affected By Connector enhancer of kinase suppressor of ras 2 (CNKSR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[77]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[84]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[253]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[292]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[84]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[255]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[91]

Drug(s) Affected By Lysophosphatidic acid receptor 1 (LPAR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[104]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[89]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[91]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[260]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[260]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[260]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[766]

Drug(s) Affected By Zinc finger protein ubi-d4 (DPF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[274]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[153]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[227]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[205]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[277]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[274]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[274]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[365]
Hexadecanoic acid	DMWUXDZ	Discovery agent	N.A.	Investigative	[767]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 14 (TNFRSF14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[124]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[758]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[194]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[768]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[769]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[770]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[153]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[102]

Drug(s) Affected By Protein MAL2 (MAL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[253]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[393]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[103]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[111]

Drug(s) Affected By Protein TMEPAI (PMEPA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[84]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[152]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[107]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[175]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[175]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[175]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[175]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[13]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[87]

Drug(s) Affected By Serine/threonine-protein kinase Sgk3 (SGK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[604]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[84]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[604]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[152]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Mestranol	DMG3F94	Contraception	QA21	Approved	[604]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[604]

Drug(s) Affected By GRIP and coiled-coil domain-containing protein 1 (GCC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[771]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[99]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[90]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[205]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[101]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[92]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[93]
PHENCYCLIDINE	DMQBEYX	Discovery agent	N.A.	Investigative	[772]

Drug(s) Affected By Fumarylacetoacetate hydrolase domain-containing protein 2A (FAHD2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[182]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[197]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[127]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[92]
QUERCITRIN	DM1DH96	Discovery agent	N.A.	Investigative	[773]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[178]

Drug(s) Affected By Protein arginine N-methyltransferase 6 (PRMT6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[774]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[155]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[100]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[205]
Berberine	DMC5Q8X	N. A.	N. A.	Phase 4	[775]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[756]

Drug(s) Affected By E3 ubiquitin-protein ligase NEDD4-like (NEDD4L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[197]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[127]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[262]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[162]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[771]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[155]

Drug(s) Affected By Eyes absent homolog 1 (EYA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[138]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[776]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[776]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[776]
Nilotinib	DM7HXWT	Chronic myelogenous leukaemia	2A20.0	Approved	[776]
Ramelteon	DM7IW9J	Insomnia	7A00-7A0Z	Approved	[776]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[776]
Dabigatran	DMDI6R4	Stroke	8B20	Approved	[776]
Abacavir	DMMN36E	Human immunodeficiency virus infection	1C62	Approved	[776]

Drug(s) Affected By Sigma non-opioid intracellular receptor 1 (SIGMAR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]
Bortezomib	DMNO38U	Leukemia		Approved	[88]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]
Bardoxolone methyl	DMODA2X	Mixed connective tissue disease	4A43.3	Phase 3	[777]
URSOLIC ACID	DM4SOAW	Metabolic syndrome x	5C50-5D2Z	Phase 2	[777]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[81]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[777]

Drug(s) Affected By Apolipoprotein L2 (APOL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[127]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[103]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[205]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[778]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[779]
Nickel chloride	DMI12Y8	Discovery agent	N.A.	Investigative	[780]
Manganese	DMKT129	N. A.	N. A.	Investigative	[781]

Drug(s) Affected By Allograft inflammatory factor 1-like (AIF1L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[561]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[561]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[262]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[87]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[244]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[205]

Drug(s) Affected By Synaptotagmin-11 (SYT11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[84]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[87]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[91]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[205]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[84]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[782]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[92]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[93]

Drug(s) Affected By Mitochondrial adenyl nucleotide antiporter SLC25A23 (SLC25A23)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[152]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[783]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[13]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[183]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[784]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[90]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[785]

Drug(s) Affected By Oxysterol-binding protein-related protein 1 (OSBPL1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[104]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[131]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[131]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[87]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[90]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[205]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[104]

Drug(s) Affected By Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (NUCKS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Selenium	DM25CGV	N. A.	N. A.	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[13]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[381]
Bortezomib	DMNO38U	Leukemia		Approved	[88]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[155]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[786]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[90]

Drug(s) Affected By Semaphorin-6A (SEMA6A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[152]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[128]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[227]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[327]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[90]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[101]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[84]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[276]

Drug(s) Affected By E3 ubiquitin-protein ligase MARCHF7 (MARCHF7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[253]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[369]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[111]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[277]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[92]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[325]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[779]

Drug(s) Affected By Serine/threonine-protein kinase PAK 6 (PAK6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[129]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[135]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[84]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[661]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[92]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[93]

Drug(s) Affected By Beta-catenin-interacting protein 1 (CTNNBIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[262]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[376]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[87]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[84]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[787]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[274]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[138]

Drug(s) Affected By Protein lin-7 homolog C (LIN7C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[68]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[163]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[90]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[260]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[93]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[325]

Drug(s) Affected By Mitoferrin-1 (SLC25A37)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[104]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[262]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[247]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[253]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[13]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[103]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[232]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[84]

Drug(s) Affected By Leucine-rich repeat transmembrane protein FLRT3 (FLRT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Selenium	DM25CGV	N. A.	N. A.	Approved	[104]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[158]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[135]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[247]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[376]

Drug(s) Affected By Sodium/hydrogen exchanger 2 (SLC9A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[185]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[92]

Drug(s) Affected By Klotho (KL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[158]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[788]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[232]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[789]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[789]
GUAIACOL	DMN4E7T	N. A.	N. A.	Phase 3	[789]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[789]
Puerarin	DMJIMXH	Alcohol dependence	6C40.2	Phase 2	[789]

Drug(s) Affected By ProSAAS (PCSK1N)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[262]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[91]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[92]
UNC0379	DMD1E4J	Hepatocellular carcinoma	2C12.02	Preclinical	[177]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[790]

Drug(s) Affected By Protein FAM153A (FAM153A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[13]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[373]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[791]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[205]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[92]
Maleic Acid	DM4L0R7	Discovery agent	N.A.	Investigative	[792]

Drug(s) Affected By Ectonucleotide pyrophosphatase/phosphodiesterase family member 5 (ENPP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[138]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[481]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[185]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[101]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[101]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[276]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[92]
biochanin A	DM0HPWY	Discovery agent	N.A.	Investigative	[793]

Drug(s) Affected By Probable ATP-dependent RNA helicase DDX41 (DDX41)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[104]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[794]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[90]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[104]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[757]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[93]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[274]

Drug(s) Affected By Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (HCN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[185]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[795]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[205]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[185]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[81]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[93]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[138]

Drug(s) Affected By Protein NDRG2 (NDRG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[796]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[380]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[797]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]

Drug(s) Affected By SH3 and multiple ankyrin repeat domains protein 2 (SHANK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Selenium	DM25CGV	N. A.	N. A.	Approved	[104]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[666]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[666]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[666]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[798]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]

Drug(s) Affected By Paraplegin (SPG7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[104]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[262]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[155]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[183]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[90]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[92]

Drug(s) Affected By Solute carrier family 22 member 14 (SLC22A14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[464]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[227]

Drug(s) Affected By UDP-N-acetylglucosamine transporter (SLC35A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[138]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[262]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[103]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[92]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[325]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[799]
crotylaldehyde	DMTWRQI	Discovery agent	N.A.	Investigative	[800]

Drug(s) Affected By Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform (PPP2R2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[801]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[234]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[802]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[292]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[110]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[101]
Testosterone undecanoate	DMZO10Y	Hypogonadism	5A61.0	Approved	[526]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[802]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[205]

Drug(s) Affected By Protocadherin gamma-A1 (PCDHGA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[803]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[90]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[210]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[804]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[138]

Drug(s) Affected By Protocadherin alpha-2 (PCDHA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[84]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[92]

Drug(s) Affected By Mu-type opioid receptor (OPRM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Alvimopan	DMHR8KW	Gastrointestinal disease	DE2Z	Approved	[805]
Fentanyl	DM8WAHT	Analgesia	MB40.8	Approved	[806]
Morphine	DMRMS0L	Advanced cancer	2A00-2F9Z	Approved	[807]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[77]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[808]
Butorphanol	DM5KYPJ	Pain	MG30-MG3Z	Approved	[809]
Oliceridine	DM6MDCF	Acute pain	MG31	Approved	[806]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[810]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[811]

Drug(s) Affected By Sodium-dependent dopamine transporter (SLC6A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[812]
Amphetamine	DMSZQAK	Attention deficit hyperactivity disorder	6A05.Z	Approved	[813]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[814]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[815]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[131]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[131]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Dextroamphetamine	DMMIHVP	Attention deficit hyperactivity disorder	6A05.Z	Approved	[643]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[101]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[816]

Drug(s) Affected By Calcium/calmodulin-dependent protein kinase type IV (CAMK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[256]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[101]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[817]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[818]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[819]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[818]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[101]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[820]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[93]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[138]

Drug(s) Affected By Collagen alpha-1(XXI) chain (COL21A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[155]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[99]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[90]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[84]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[91]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[84]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[84]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[92]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[821]

Drug(s) Affected By Neuromedin-K receptor (TACR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[292]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[92]

Drug(s) Affected By Liver carboxylesterase 1 (CES1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[822]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[137]
Dextropropoxyphene	DM23HCX	Pain	MG30-MG3Z	Approved	[76]
Selenium	DM25CGV	N. A.	N. A.	Approved	[104]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[823]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[824]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[74]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[197]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[263]

Drug(s) Affected By D(4) dopamine receptor (DRD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[825]
Haloperidol	DM96SE0	Delirium		Approved	[826]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[376]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[87]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Methamphetamine	DMPM4SK	Anxiety		Approved	[827]
Droperidol	DM0DXA8	Nausea	MD90	Approved	[14]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[14]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[14]

Drug(s) Affected By Dopamine beta-hydroxylase (DBH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[828]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Levodopa	DMN3E57	Parkinson disease	8A00.0	Approved	[829]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[99]
Bromocriptine	DMVE3TK	Acromegaly	5A60.0	Approved	[829]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[830]
Artesunate	DMR27C8	Infection of P. falciparum	1F40	Approved	[831]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[832]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[205]

Drug(s) Affected By Cannabinoid receptor 1 (CNR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[206]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[833]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[153]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[87]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[380]
Norepinephrine	DMOUC09	Alopecia	ED70	Approved	[834]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[811]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]

Drug(s) Affected By Synaptotagmin-13 (SYT13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[364]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[102]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[97]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[297]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[92]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[93]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[138]

Drug(s) Affected By Dynein axonemal heavy chain 8 (DNAH8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[155]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[92]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[138]

Drug(s) Affected By Neuronal acetylcholine receptor subunit alpha-5 (CHRNA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[253]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[835]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[87]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[99]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[81]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[836]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[101]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[837]

Drug(s) Affected By Little elongation complex subunit 2 (ICE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[262]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[377]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[292]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[90]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[838]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[101]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[92]

Drug(s) Affected By Brain-derived neurotrophic factor (BDNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Haloperidol	DM96SE0	Delirium		Approved	[839]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[328]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[180]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Bupivacaine	DM4PRFC	Anaesthesia	9A78.6	Approved	[840]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[841]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[152]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[135]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]

Drug(s) Affected By Glutathione S-transferase P (GSTP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[842]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[843]
Chlorambucil	DMRKE63	Chronic lymphocytic leukaemia	2A82.0	Approved	[843]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[844]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[845]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Selenium	DM25CGV	N. A.	N. A.	Approved	[104]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[145]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[846]

Drug(s) Affected By Voltage-dependent L-type calcium channel subunit alpha-1D (CACNA1D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[153]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[324]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[91]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[92]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[847]

Drug(s) Affected By CD81 antigen (CD81)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[206]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[138]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[330]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[225]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[250]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[87]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[227]

Drug(s) Affected By Kelch-like protein 5 (KLHL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[331]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[135]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[127]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[262]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[87]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[163]

Drug(s) Affected By Probable phospholipid-transporting ATPase IIB (ATP9B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[106]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[155]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[848]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[787]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[365]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[253]
1,6-hexamethylene diisocyanate	DMLB3RT	Discovery agent	N.A.	Investigative	[849]

Drug(s) Affected By Glycoprotein endo-alpha-1,2-mannosidase (MANEA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[660]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[99]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[81]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[90]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[820]

Drug(s) Affected By Serine-rich coiled-coil domain-containing protein 1 (CCSER1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[155]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[255]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[92]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[138]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[247]

Drug(s) Affected By Homer protein homolog 1 (HOMER1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Selenium	DM25CGV	N. A.	N. A.	Approved	[104]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[152]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[262]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[376]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[155]

Drug(s) Affected By Teneurin-3 (TENM3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[128]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[99]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[324]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[90]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[101]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[92]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Dopamine transporter (DAT)	TTVBI8W	SC6A3_HUMAN	Inhibitor	[3]
Norepinephrine transporter (NET)	TTAWNKZ	SC6A2_HUMAN	Inhibitor	[3]
Serotonin transporter (SERT)	TT3ROYC	SC6A4_HUMAN	Inhibitor	[3]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Substrate	[4]
Cytochrome P450 2D6 (CYP2D6)	DECB0K3	CP2D6_HUMAN	Substrate	[5]
Cytochrome P450 3A5 (CYP3A5)	DEIBDNY	CP3A5_HUMAN	Substrate	[6]
Cytochrome P450 3A7 (CYP3A7)	DERD86B	CP3A7_HUMAN	Substrate	[7]
Butyrylcholine esterase (BCHE)	DEIHSMD	CHLE_HUMAN	Substrate	[8]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
14-3-3 protein epsilon	OT3WQXNA	1433E_HUMAN	Gene/Protein Processing	[9]
14-3-3 protein eta	OTP8NJFJ	1433F_HUMAN	Gene/Protein Processing	[10]
5-hydroxymethyl-dUMP N-hydrolase (DNPH1)	OTEZVTI1	DNPH1_HUMAN	Gene/Protein Processing	[11]
60 kDa heat shock protein, mitochondrial (HSPD1)	OTTO1Y11	CH60_HUMAN	Gene/Protein Processing	[12]
Actin, gamma-enteric smooth muscle (ACTG2)	OTRDWUO0	ACTH_HUMAN	Gene/Protein Processing	[9]
Adenylate kinase isoenzyme 1 (AK1)	OT614AR3	KAD1_HUMAN	Gene/Protein Processing	[11]
Adropin (ENHO)	OT91QASK	ENHO_HUMAN	Gene/Protein Processing	[13]
Alanine aminotransferase 1 (GPT)	OTOXOA0Q	ALAT1_HUMAN	Drug Response	[14]
Allograft inflammatory factor 1-like (AIF1L)	OTDEOB80	AIF1L_HUMAN	Gene/Protein Processing	[11]
Alpha-actinin-2 (ACTN2)	OT9FOLD7	ACTN2_HUMAN	Gene/Protein Processing	[11]

References

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