Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMTSGOW)

• Drug Name: [3H]methyltrienolone Drug Info
• Synonyms: Methyltrienolone; METRIBOLONE; 965-93-5; R1881; Metribolona; 17alpha-Methyltrienolone; Metribolonum; RU 1881; Ru-1881; R 1881; UNII-2C323EGI97; 17beta-Hydroxy-17-methylestra-4,9,11-trien-3-one; 17-beta-Hydroxy-17-methylestra-4,9,11-trien-3-one; R-1881; R1881 (synthetic androgen); CHEBI:379896; 2C323EGI97; (17BETA)-17-HYDROXY-17-METHYLESTRA-4,9,11-TRIEN-3-ONE; 17-methyloestra-4,9,11-trien-3-one,17beta-ol; 17-beta-hydroxy-17-methylestra-4,9,11-trien-3-one (9CI); Estra-4,9,11-trien-3-one, 17-hydroxy-17-methyl-, (17b)-; [3H]-R1881; [3H]R1881

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 261000
  ChEBI ID: CHEMBL166444
  CAS Number: CAS 965-93-5
  TTD Drug ID: DMTSGOW

Molecule-Related Drug Atlas

Drug(s) Targeting Androgen receptor (AR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[7]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[8]
Darolutamide	DMV7YFT	Prostate cancer	2C82.0	Approved	[9]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[10]
Flufenamic Acid	DMC8VNH	Dysmenorrhea	GA34.3	Approved	[11]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[12]
Fludrocortisone	DMUDIR8	Addison disease	5A74.0	Approved	[13]
ARN-509	DMT81LZ	Acute myeloid leukaemia	2A60	Approved	[14]
Nilutamide	DMFN07X	Prostate cancer	2C82.0	Approved	[15]
Nandrolone	DMFWKG1	Osteoporosis	FB83.0	Approved	[16]

Drug(s) Targeting Progesterone receptor (PGR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[17]
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[18]
Ulipristal	DMBNI20	Contraception	QA21	Approved	[19]
Etonogestrel	DMKA8J4	Contraception	QA21	Approved	[20]
Megestrol	DMDH9KX	Breast cancer	2C60-2C65	Approved	[21]
Segesterone acetate; ethinyl estradiol	DMFEGB0	Contraception	QA21	Approved	[14]
Norgestimate	DMYP4XC	Acne vulgaris	ED80	Approved	[20]
Dydrogesterone	DMAKIDV	Menstrual disorder	GA20.3	Approved	[22]
Medroxyprogesterone	DMBGWPH	Solid tumour/cancer	2A00-2F9Z	Approved	[22]
Ethynodiol Diacetate	DMZM84R	Contraception	QA21	Approved	[23]

Drug(s) Targeting Androgen receptor messenger RNA (AR mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[3]
BAY 86-5044	DMRZLU4	Breast cancer	2C60-2C65	Phase 2	[24]
TRC-253	DMXI8CD	Prostate cancer	2C82.0	Phase 1/2	[25]
IONIS-AR-2.5Rx	DMF2DMS	Prostate cancer	2C82.0	Phase 1/2	[26]
ISIS-AR	DM8P3N5	Prostate cancer	2C82.0	Phase 1	[27]
EZN-4176	DMNPS59	Prostate cancer	2C82.0	Phase 1	[28]
EUGENOL	DM7US1H	Discovery agent	N.A.	Patented	[29]
RU-58841	DMMEAZ2	Acne vulgaris	ED80	Discontinued in Phase 1	[30]
flavone	DMEQH6J	Discovery agent	N.A.	Investigative	[31]
APIGENIN	DMI3491	Discovery agent	N.A.	Investigative	[31]

Drug(s) Affected By RNA polymerase II elongation factor ELL2 (ELL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[32]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[33]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[36]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[40]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[41]

Drug(s) Affected By Suppressor of cytokine signaling 2 (SOCS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[42]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[43]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[43]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[44]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[45]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[46]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[47]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[49]

Drug(s) Affected By Insulin-induced gene 1 protein (INSIG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[50]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[51]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[54]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[36]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[53]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[55]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[46]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[56]

Drug(s) Affected By Acyl-CoA (FADS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[36]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[46]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[46]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[58]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[59]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[60]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[62]

Drug(s) Affected By Ecotropic viral integration site 5 protein homolog (EVI5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[63]
Selenium	DM25CGV	N. A.	N. A.	Approved	[64]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[65]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[47]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[68]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[69]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[70]

Drug(s) Affected By Transcription factor Maf (MAF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[42]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[40]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[72]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[73]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[74]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[33]

Drug(s) Affected By E3 SUMO-protein ligase PIAS1 (PIAS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[75]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[46]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[46]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[75]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[76]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[40]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[64]

Drug(s) Affected By Fatty acid CoA ligase Acsl3 (ACSL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[51]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[36]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[46]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[79]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[81]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[82]

Drug(s) Affected By Transmembrane protein 50A (TMEM50A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[69]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[86]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[87]
Forskolin	DM6ITNG	Solid tumour/cancer	2A00-2F9Z	Investigative	[88]
methyl p-hydroxybenzoate	DMO58UW	Discovery agent	N.A.	Investigative	[89]

Drug(s) Affected By Alpha-1-acid glycoprotein 1 (ORM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lidocaine	DML4ZOT	Anaesthesia	9A78.6	Approved	[90]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[44]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[90]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[46]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[46]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]

Drug(s) Affected By Guanine nucleotide-binding protein G(i) subunit alpha-3 (GNAI3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[93]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]
Bortezomib	DMNO38U	Leukemia		Approved	[41]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[94]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[95]

Drug(s) Affected By Kallikrein-2 (KLK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[96]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[97]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[46]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[98]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[40]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Dutasteride	DMQ4TJK	Benign prostatic hyperplasia	GA90	Approved	[99]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[100]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[101]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[102]

Drug(s) Affected By Receptor-type tyrosine-protein phosphatase mu (PTPRM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[36]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[46]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[47]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[103]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[33]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]

Drug(s) Affected By Ataxin-3 (ATXN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[105]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[106]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[107]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[108]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[109]

Drug(s) Affected By Signal peptidase complex subunit 3 (SPCS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[36]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[40]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[110]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[111]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[112]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[113]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase FKBP5 (FKBP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[115]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[116]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[117]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[46]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[46]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[118]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[119]

Drug(s) Affected By Ensconsin (MAP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[120]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[106]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[107]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[69]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[122]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[123]

Drug(s) Affected By RRP12-like protein (RRP12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[124]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[125]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[126]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[56]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[127]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[56]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[123]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[56]

Drug(s) Affected By Rho-related GTP-binding protein RhoU (RHOU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[33]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[128]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[40]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[130]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[131]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[106]

Drug(s) Affected By Transcription termination factor 4, mitochondrial (MTERF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[41]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[70]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[111]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[133]
Forskolin	DM6ITNG	Solid tumour/cancer	2A00-2F9Z	Investigative	[88]

Drug(s) Affected By Protein odd-skipped-related 2 (OSR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[33]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[46]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[47]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[134]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[60]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[135]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[136]

Drug(s) Affected By Zinc transporter 7 (SLC30A7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[137]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[138]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[107]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[70]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[40]

Drug(s) Affected By Neuron navigator 1 (NAV1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[139]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[44]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[47]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[140]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[60]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[135]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]

Drug(s) Affected By Amyloid protein-binding protein 2 (APPBP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[46]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[134]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[40]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[64]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[111]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[141]

Drug(s) Affected By Dynein light chain 2, cytoplasmic (DYNLL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[142]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[143]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[40]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[86]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[144]

Drug(s) Affected By Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase (NGLY1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[123]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[145]
Forskolin	DM6ITNG	Solid tumour/cancer	2A00-2F9Z	Investigative	[88]

Drug(s) Affected By Calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[56]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[56]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[68]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[146]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]

Drug(s) Affected By cAMP-dependent protein kinase inhibitor beta (PKIB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[52]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[147]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[121]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[52]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[140]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[68]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[101]

Drug(s) Affected By Mediator of RNA polymerase II transcription subunit 28 (MED28)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[63]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[148]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[141]
Forskolin	DM6ITNG	Solid tumour/cancer	2A00-2F9Z	Investigative	[88]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[149]

Drug(s) Affected By Cardiolipin synthase (CRLS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[133]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[150]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[47]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[41]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[151]

Drug(s) Affected By Sestrin-1 (SESN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[152]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[153]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[154]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[155]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[156]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[46]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[46]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[37]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[56]

Drug(s) Affected By ATP-binding cassette sub-family C member 4 (ABCC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[157]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[158]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[159]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[160]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[115]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[161]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[162]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[134]

Drug(s) Affected By Glycine receptor subunit alpha-2 (GLRA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[163]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[145]

Drug(s) Affected By Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (MAN1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[36]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[44]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[120]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[164]

Drug(s) Affected By OX-2 membrane glycoprotein (CD200)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[165]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[105]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[166]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[70]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[123]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[70]

Drug(s) Affected By Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (PIP4K2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[123]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[130]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[167]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[107]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[70]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[111]

Drug(s) Affected By Glycine N-methyltransferase (GNMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[52]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[46]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[46]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[168]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[52]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[40]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]

Drug(s) Affected By Probable E3 ubiquitin-protein ligase HERC3 (HERC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[56]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[56]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[56]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[69]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[169]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[143]

Drug(s) Affected By Microtubule-associated protein RP/EB family member 2 (MAPRE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[170]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[170]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[56]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[56]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[86]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[145]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[125]

Drug(s) Affected By ELL-associated factor 2 (EAF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[171]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[172]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[47]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[171]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[173]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[174]

Drug(s) Affected By Centromere protein N (CENPN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[175]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[70]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[176]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[69]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[177]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[122]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[70]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[40]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[177]

Drug(s) Affected By M-phase phosphoprotein 9 (MPHOSPH9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[178]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[118]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[69]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[177]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[40]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[177]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[125]

Drug(s) Affected By Specifically androgen-regulated gene protein (C1ORF116)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[33]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[65]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[179]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[40]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[107]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[101]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[40]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[86]

Drug(s) Affected By Disintegrin and metalloproteinase domain-containing protein 7 (ADAM7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PEITC	DMOMN31	Prostate cancer	2C82.0	Phase 2	[180]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[145]

Drug(s) Affected By AH receptor-interacting protein (AIP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[64]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[43]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[43]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[136]

Drug(s) Affected By Serine protease HTRA2, mitochondrial (HTRA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[181]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[182]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[154]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[46]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[183]
Bortezomib	DMNO38U	Leukemia		Approved	[184]

Drug(s) Affected By Perilipin-3 (PLIN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[123]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[106]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[106]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[186]

Drug(s) Affected By Gamma-glutamylcyclotransferase (GGCT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[187]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[107]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[101]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[188]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[186]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[145]

Drug(s) Affected By Isocitrate dehydrogenase cytoplasmic (IDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[189]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[36]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[190]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[191]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[107]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[68]

Drug(s) Affected By Prelamin-A/C (LMNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[64]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[128]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[192]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[193]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[194]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[190]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[105]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]

Drug(s) Affected By Ferritin heavy chain (FTH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[195]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[196]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[197]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[65]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[139]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[198]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[199]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[200]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[56]

Drug(s) Affected By Keratin, type II cytoskeletal 1 (KRT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[201]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[202]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[43]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[190]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[130]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[43]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[203]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[69]

Drug(s) Affected By Heat shock protein beta-1 (HSPB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[181]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[50]
Selenium	DM25CGV	N. A.	N. A.	Approved	[64]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[204]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[75]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[205]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[45]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[206]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[70]

Drug(s) Affected By Keratin, type I cytoskeletal 18 (KRT18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[207]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[133]
Selenium	DM25CGV	N. A.	N. A.	Approved	[64]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[208]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[209]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[193]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[44]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[210]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[121]

Drug(s) Affected By Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[63]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Tetracaine	DM9J6C2	Spinal anesthesia	MB40.3	Approved	[211]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[118]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[212]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]

Drug(s) Affected By Small ribosomal subunit protein uS2 (RPSA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[50]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[213]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[214]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[215]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[216]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[217]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[218]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]

Drug(s) Affected By Gamma-enolase (ENO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[64]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[219]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[220]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[221]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[222]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[37]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[56]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[56]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]

Drug(s) Affected By Annexin A4 (ANXA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[33]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[193]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[134]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[223]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[173]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[60]

Drug(s) Affected By Ribose-phosphate pyrophosphokinase 2 (PRPS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[93]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[224]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[107]

Drug(s) Affected By Creatine kinase B-type (CKB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[225]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[33]
Selenium	DM25CGV	N. A.	N. A.	Approved	[64]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[43]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[43]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[226]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[227]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]

Drug(s) Affected By Elongation factor 2 (EEF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[228]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[190]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[229]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[230]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[231]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[231]

Drug(s) Affected By Keratin, type I cytoskeletal 10 (KRT10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[232]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[43]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[43]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[46]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[46]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[190]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[123]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[43]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]

Drug(s) Affected By Aldo-keto reductase family 1 member A1 (AKR1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[233]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[123]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[140]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[143]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[123]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[233]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[86]

Drug(s) Affected By Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[154]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[105]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Bortezomib	DMNO38U	Leukemia		Approved	[41]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[136]

Drug(s) Affected By 26S proteasome regulatory subunit 6A (PSMC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[234]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[235]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[236]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[236]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[237]

Drug(s) Affected By Peroxiredoxin-6 (PRDX6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[238]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[42]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[239]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[240]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[241]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[60]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[242]

Drug(s) Affected By Protein disulfide-isomerase A3 (PDIA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[243]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[244]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[228]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[236]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[236]

Drug(s) Affected By 3-hydroxyisobutyrate dehydrogenase, mitochondrial (HIBADH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[133]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[154]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[138]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[33]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[151]

Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[63]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[201]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[246]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[45]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]

Drug(s) Affected By Stress-induced-phosphoprotein 1 (STIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[181]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[247]
Haloperidol	DM96SE0	Delirium		Approved	[236]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[148]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[236]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[236]
Mecamylamine	DMGQFYB	Essential hypertension	BA00	Approved	[148]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[248]

Drug(s) Affected By Serpin B5 (SERPINB5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[249]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[128]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[250]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[121]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[251]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[56]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[252]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[135]

Drug(s) Affected By Transaldolase (TALDO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[64]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[36]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[147]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[253]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[56]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[56]

Drug(s) Affected By Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial (ACADSB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[121]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[58]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Chenodiol	DMQ8JIK	Cholelithiasis	DC11	Approved	[254]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[151]

Drug(s) Affected By F-actin-capping protein subunit beta (CAPZB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[64]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[255]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[240]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[108]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[40]

Drug(s) Affected By Coatomer subunit delta (ARCN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[256]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[257]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[257]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[258]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[259]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[260]

Drug(s) Affected By 4-trimethylaminobutyraldehyde dehydrogenase (ALDH9A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[236]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[248]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]

Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein F (HNRNPF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[227]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[261]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[257]
ACYLINE	DM9GRTK	Prostate cancer	2C82.0	Phase 2	[262]
PEITC	DMOMN31	Prostate cancer	2C82.0	Phase 2	[180]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[263]

Drug(s) Affected By Spermine synthase (SMS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[264]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[264]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[154]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[264]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[138]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[264]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[264]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[265]

Drug(s) Affected By F-actin-capping protein subunit alpha-1 (CAPZA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[63]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[263]
PMID28870136-Compound-48	DMPIM9L	N. A.	N. A.	Patented	[266]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[267]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[268]

Drug(s) Affected By Alpha-soluble NSF attachment protein (NAPA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[64]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[269]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[141]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[259]
D-glucose	DMMG2TO	Discovery agent	N.A.	Investigative	[270]

Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein H2 (HNRNPH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[147]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[271]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[86]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[272]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[263]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[145]

Drug(s) Affected By Actin, cytoplasmic 1 (ACTB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[234]
Selenium	DM25CGV	N. A.	N. A.	Approved	[64]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[244]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[273]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[147]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]

Drug(s) Affected By Proteasome activator complex subunit 3 (PSME3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[274]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[228]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[275]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[276]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[277]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[278]

Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein K (HNRNPK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[125]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[279]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[280]
Haloperidol	DM96SE0	Delirium		Approved	[236]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[281]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[240]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[282]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[280]

Drug(s) Affected By 26S proteasome regulatory subunit 4 (PSMC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[64]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[236]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[283]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[64]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[263]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[141]
MG-132	DMKA2YS	N. A.	N. A.	Preclinical	[284]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[133]

Drug(s) Affected By Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform (PPP2R2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[133]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[105]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[138]
Bortezomib	DMNO38U	Leukemia		Approved	[41]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[285]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[286]

Drug(s) Affected By Actin, cytoplasmic 2 (ACTG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[64]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[139]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[147]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[281]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[107]

Drug(s) Affected By Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[236]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[133]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[33]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[287]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[287]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[288]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[287]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[42]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]

Drug(s) Affected By Rho GTPase-activating protein 1 (ARHGAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[65]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[123]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[138]
Bortezomib	DMNO38U	Leukemia		Approved	[41]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]

Drug(s) Affected By Serine/threonine-protein kinase PAK 2 (PAK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[289]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[285]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[68]

Drug(s) Affected By 26S proteasome non-ATPase regulatory subunit 2 (PSMD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[64]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[263]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[145]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[125]
MG-132	DMKA2YS	N. A.	N. A.	Preclinical	[284]

Drug(s) Affected By Methanethiol oxidase (SELENBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[290]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[220]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[60]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[220]
Estriol	DMOEM2I	Hormone deficiency	5A61.1	Approved	[220]

Drug(s) Affected By Isopentenyl-diphosphate Delta-isomerase 1 (IDI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[288]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[51]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[42]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[291]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[36]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase FKBP8 (FKBP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[65]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[43]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[43]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[118]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[236]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[292]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[293]

Drug(s) Affected By Septin-2 (SEPTIN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[294]
CH-223191	DMMJZYC	Solid tumour/cancer	2A00-2F9Z	Investigative	[295]
ELLAGIC ACID	DMX8BS5	Discovery agent	N.A.	Investigative	[296]

Drug(s) Affected By Protein disulfide-isomerase A6 (PDIA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[133]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[289]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[40]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[297]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[258]

Drug(s) Affected By Tubulin-specific chaperone C (TBCC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[123]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[138]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[298]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[86]

Drug(s) Affected By MICOS complex subunit MIC60 (IMMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[193]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[131]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[151]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[145]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[294]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[66]

Drug(s) Affected By Pyridoxal-dependent decarboxylase domain-containing protein 1 (PDXDC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[154]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[33]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]

Drug(s) Affected By Probable D-lactate dehydrogenase, mitochondrial (LDHD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[33]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[44]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[106]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[106]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[33]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]

Drug(s) Affected By Nuclear protein localization protein 4 homolog (NPLOC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[236]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[69]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[87]

Drug(s) Affected By Programmed cell death 6-interacting protein (PDCD6IP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[47]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[299]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[74]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[300]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[301]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[302]

Drug(s) Affected By Phosphopentomutase (PGM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[150]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[93]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[303]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[40]

Drug(s) Affected By DCN1-like protein 1 (DCUN1D1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[105]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[86]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[87]

Drug(s) Affected By Cytosolic non-specific dipeptidase (CNDP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[36]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[190]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[304]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[86]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[145]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[125]

Drug(s) Affected By Elongation factor G, mitochondrial (GFM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[105]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[275]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[145]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[125]

Drug(s) Affected By Parkinson disease protein 7 (PARK7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[305]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[306]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[123]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[289]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[307]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[151]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[308]
Sodium phenylbutyrate	DMXLBCQ	Spinal muscular atrophy	8B61	Approved	[309]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[310]

Drug(s) Affected By Endoplasmic reticulum resident protein 44 (ERP44)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[40]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[44]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[258]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[311]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[312]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[87]

Drug(s) Affected By Neurolysin, mitochondrial (NLN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[136]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Sodium phenylbutyrate	DMXLBCQ	Spinal muscular atrophy	8B61	Approved	[313]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[86]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[44]

Drug(s) Affected By Nucleotide exchange factor SIL1 (SIL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[106]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[314]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[68]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[145]

Drug(s) Affected By Glyoxalase domain-containing protein 4 (GLOD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[315]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[240]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[315]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[315]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[315]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[151]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[114]

Drug(s) Affected By Adipocyte plasma membrane-associated protein (APMAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[145]
SB-431542	DM0YOXQ	Pulmonary fibrosis	CB03.4	Preclinical	[316]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[259]

Drug(s) Affected By Sialic acid synthase (NANS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[44]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[228]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[69]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]

Drug(s) Affected By 4'-phosphopantetheine phosphatase (PANK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[64]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[107]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[145]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[125]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[259]

Drug(s) Affected By Succinate--CoA ligase subunit beta, mitochondrial (SUCLA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[79]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[317]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[68]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[283]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[186]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[186]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[145]

Drug(s) Affected By Hypoxia up-regulated protein 1 (HYOU1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[318]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[319]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Aminoglutethimide	DMWFHMZ	Cushing disease	5A70	Approved	[320]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[321]

Drug(s) Affected By Mitotic spindle assembly checkpoint protein MAD1 (MAD1L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[322]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[323]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[167]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[68]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[177]

Drug(s) Affected By Retinaldehyde dehydrogenase 3 (ALDH1A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[324]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[325]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[44]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[326]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[45]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[46]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[46]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[56]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[56]

Drug(s) Affected By Plasminogen activator inhibitor 1 (SERPINE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[327]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[328]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[329]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[330]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[331]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[332]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[42]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[333]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[115]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[334]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[335]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[336]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[337]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[338]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[339]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[340]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[341]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[152]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[342]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[341]

Drug(s) Affected By Arginase-2, mitochondrial (ARG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[32]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[343]
Selenium	DM25CGV	N. A.	N. A.	Approved	[64]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[124]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[36]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[318]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[344]

Drug(s) Affected By Putative POTE ankyrin domain family member M (POTEM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[63]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[46]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[171]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[171]
Nabiximols	DMHKJ5I	Cancer related pain	MG30	Phase 3	[345]
MGCD-0103	DM726HX	Non-small-cell lung cancer	2C25.Y	Phase 2	[171]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[144]
Tacedinaline	DM1Z74X	Solid tumour/cancer	2A00-2F9Z	Discontinued in Phase 2	[171]

Drug(s) Affected By Galectin-8 (LGALS8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[147]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[47]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[271]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[173]
Bortezomib	DMNO38U	Leukemia		Approved	[41]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]

Drug(s) Affected By Receptor-binding cancer antigen expressed on SiSo cells (EBAG9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[225]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[138]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[346]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[346]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[141]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[125]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[347]

Drug(s) Affected By Cyclin-dependent kinase 2-associated protein 1 (CDK2AP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[135]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[348]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[145]
Scriptaid	DM9JZ21	Solid tumour/cancer	2A00-2F9Z	Preclinical	[349]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[350]

Drug(s) Affected By Serine/threonine-protein kinase Chk1 (CHEK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[351]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[249]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[352]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[353]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[354]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[139]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[355]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[356]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[357]

Drug(s) Affected By U6 snRNA-associated Sm-like protein LSm1 (LSM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[33]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[268]
paraquat	DMR8O3X	Discovery agent	N.A.	Investigative	[358]

Drug(s) Affected By Protein CASC3 (CASC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[70]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[359]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[125]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[125]

Drug(s) Affected By High affinity copper uptake protein 1 (SLC31A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[360]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[360]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[36]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[361]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
TRIENTINE	DMD2WPG	Inborn error of metabolism	5C50-5C59	Approved	[360]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[362]

Drug(s) Affected By Period circadian protein homolog 1 (PER1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[363]
Haloperidol	DM96SE0	Delirium		Approved	[364]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[365]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[366]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[174]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[367]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[107]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]

Drug(s) Affected By Claudin-3 (CLDN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[33]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[121]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Guanfacine extended release	DMB1CZ8	Attention deficit hyperactivity disorder	6A05.Z	Approved	[368]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Sanguinarine	DMDINFS	Dental plaque	DA08.4	Approved	[369]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[41]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[62]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[33]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[370]

Drug(s) Affected By Mitotic checkpoint serine/threonine-protein kinase BUB1 (BUB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[351]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[371]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[343]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[124]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[139]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[46]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[46]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[37]

Drug(s) Affected By Ribosome quality control complex subunit NEMF (NEMF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[141]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[125]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[133]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[87]

Drug(s) Affected By Checkpoint protein HUS1 (HUS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[36]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[154]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[372]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[174]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[68]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[143]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[86]

Drug(s) Affected By Breast carcinoma-amplified sequence 1 (BCAS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[46]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[47]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[33]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[101]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[136]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[86]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[373]

Drug(s) Affected By Large neutral amino acids transporter small subunit 3 (SLC43A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[291]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[75]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[44]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[291]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[46]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[46]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[187]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[75]

Drug(s) Affected By Transforming acidic coiled-coil-containing protein 1 (TACC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[374]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[33]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[44]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[147]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[106]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[107]

Drug(s) Affected By P antigen family member 1 (PAGE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[101]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[375]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[376]

Drug(s) Affected By Protein JTB (JTB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[107]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[377]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[145]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[141]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[87]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[260]

Drug(s) Affected By NADH dehydrogenase 1 alpha subcomplex subunit 3 (NDUFA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[36]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[378]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[146]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[186]

Drug(s) Affected By Membrane protein BRI3 (BRI3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[146]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[348]

Drug(s) Affected By Serine/threonine-protein kinase Chk2 (CHEK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[379]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[351]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[380]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[355]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[154]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[381]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[46]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[382]

Drug(s) Affected By Cytochrome c oxidase subunit 1 (COX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zalcitabine	DMH7MUV	Human immunodeficiency virus infection	1C62	Approved	[383]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[384]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[385]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[45]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[386]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[387]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[388]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[389]
Nicotinamide	DMUPE07	Acne vulgaris	ED80	Approved	[385]

Drug(s) Affected By Cytochrome c oxidase subunit 3 (COX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[390]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[200]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[58]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Zalcitabine	DMH7MUV	Human immunodeficiency virus infection	1C62	Approved	[391]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[392]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[393]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[393]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[394]

Drug(s) Affected By Aspartate aminotransferase, mitochondrial (GOT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[133]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[147]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[395]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[396]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[283]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[324]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[257]

Drug(s) Affected By ATP synthase subunit a (ATP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[397]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[390]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[398]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[58]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[392]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[378]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[399]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]

Drug(s) Affected By Osteocalcin (BGLAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[400]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[401]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[402]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[403]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[404]
Pamidronate	DMB4AVP	Bone Paget disease		Approved	[405]
Falecalcitrol	DMBI9ZJ	Hyperparathyroidism	5A51	Approved	[406]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[407]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[187]

Drug(s) Affected By NADH-ubiquinone oxidoreductase chain 2 (ND2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[390]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[200]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[58]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[378]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[258]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[408]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[113]
methyl p-hydroxybenzoate	DMO58UW	Discovery agent	N.A.	Investigative	[89]

Drug(s) Affected By NADH-ubiquinone oxidoreductase chain 4 (ND4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[390]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[198]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[58]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[409]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[410]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[411]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[86]

Drug(s) Affected By Fructose-bisphosphate aldolase A (ALDOA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[64]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[244]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[209]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[201]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[42]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[53]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[55]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[227]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[56]

Drug(s) Affected By Keratin, type II cytoskeletal 8 (KRT8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[207]
Selenium	DM25CGV	N. A.	N. A.	Approved	[64]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[209]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[412]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[139]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[207]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[44]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[93]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[190]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]

Drug(s) Affected By Parathyroid hormone-related protein (PTHLH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[65]
Ceruletide	DM2WE5K	Caerulein stimulated gastric and pancreatic secretion	5A4Y	Approved	[413]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[414]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[45]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[415]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[47]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]

Drug(s) Affected By Cadherin-1 (CDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[207]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[416]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[417]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[418]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[419]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[420]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[421]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[44]

Drug(s) Affected By Myosin light chain 6B (MYL6B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[156]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[60]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[106]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[106]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[422]

Drug(s) Affected By Ezrin (EZR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[236]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[33]
Selenium	DM25CGV	N. A.	N. A.	Approved	[64]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[44]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[154]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[423]
Haloperidol	DM96SE0	Delirium		Approved	[236]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[37]

Drug(s) Affected By Histone H2AX (H2AX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[424]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[425]
Selenium	DM25CGV	N. A.	N. A.	Approved	[64]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[426]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[427]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[428]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[429]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[430]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[431]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[432]

Drug(s) Affected By Serine/threonine-protein kinase MAK (MAK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[65]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[44]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[433]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[105]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[107]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[69]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[70]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[40]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[86]

Drug(s) Affected By Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[434]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Haloperidol	DM96SE0	Delirium		Approved	[236]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[236]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[434]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[114]

Drug(s) Affected By Sterol carrier protein 2 (SCP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[435]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[240]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[81]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[52]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[435]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]

Drug(s) Affected By cAMP-dependent protein kinase catalytic subunit beta (PRKACB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[75]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[118]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[75]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[41]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[436]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[285]

Drug(s) Affected By Nuclear receptor subfamily 4immunitygroup A member 1 (NR4A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[437]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[249]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[189]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[147]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[438]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[46]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[46]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[37]
Febuxostat	DMDEXQ0	Hyperuricaemia	5C55.Y	Approved	[439]

Drug(s) Affected By Colorectal mutant cancer protein (MCC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[44]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[440]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[44]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[86]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[44]

Drug(s) Affected By Metallothionein-3 (MT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[441]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[442]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Gallium nitrate	DMF9O6B	Hypercalcaemia	5B91.0	Approved	[443]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[60]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[444]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[445]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[446]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[447]

Drug(s) Affected By ETS domain-containing protein Elk-4 (ELK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[448]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[56]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[56]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[56]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[56]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[275]

Drug(s) Affected By Thioredoxin-dependent peroxide reductase, mitochondrial (PRDX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[50]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[449]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[450]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[217]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Aminoglutethimide	DMWFHMZ	Cushing disease	5A70	Approved	[320]

Drug(s) Affected By Protein DEK (DEK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[451]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[55]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[46]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[46]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[134]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[452]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]

Drug(s) Affected By Breast cancer type 1 susceptibility protein (BRCA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[32]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[453]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[454]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[455]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[128]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[456]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[354]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[139]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[147]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 2A (CDKN2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[351]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[63]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[457]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[458]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[353]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[459]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[460]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[461]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[462]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[463]

Drug(s) Affected By Casein kinase I isoform alpha (CSNK1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[64]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[464]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[105]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[317]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]

Drug(s) Affected By Selenoprotein P (SELENOP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[33]
Selenium	DM25CGV	N. A.	N. A.	Approved	[64]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[44]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[147]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[126]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[156]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[47]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[49]

Drug(s) Affected By Ornithine decarboxylase antizyme 1 (OAZ1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[64]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[275]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[33]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[186]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[186]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[145]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[141]

Drug(s) Affected By Large ribosomal subunit protein uL5 (RPL11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[236]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[263]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[141]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[133]
AHPN	DM8G6O4	Discovery agent	N.A.	Investigative	[465]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[260]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[466]

Drug(s) Affected By Bladder cancer-associated protein (BLCAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[135]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[68]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[70]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[143]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[447]

Drug(s) Affected By RNA-binding protein 6 (RBM6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[263]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[141]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[125]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[125]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[60]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[467]
methyl p-hydroxybenzoate	DMO58UW	Discovery agent	N.A.	Investigative	[89]

Drug(s) Affected By Nucleobindin-2 (NUCB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[272]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[156]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[46]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[468]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[60]

Drug(s) Affected By Small ribosomal subunit protein uS11m (MRPS11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[34]

Drug(s) Affected By Heat shock factor protein 1 (HSF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[469]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[470]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[470]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[471]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[472]
Ceftazidime	DM41GRA	Bacteremia	1A73	Approved	[470]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Chlorpheniramine	DM5URA2	Allergic rhinitis	CA08.0	Approved	[470]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[470]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[470]

Drug(s) Affected By 2-oxoglutarate dehydrogenase complex component E1 (OGDH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[133]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[473]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[474]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[118]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[58]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[236]
Bortezomib	DMNO38U	Leukemia		Approved	[41]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[151]

Drug(s) Affected By Peroxiredoxin-1 (PRDX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[475]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[244]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[128]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[42]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[476]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[477]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[147]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[477]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[281]

Drug(s) Affected By Serine-protein kinase ATM (ATM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[478]
Paromomycin	DM1AGXN	Amoebiasis	1A36	Approved	[479]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[454]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[480]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[481]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[482]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[75]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[483]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[484]

Drug(s) Affected By Nuclear receptor coactivator 6 (NCOA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[123]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[123]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[86]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[114]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[467]

Drug(s) Affected By 26S proteasome non-ATPase regulatory subunit 6 (PSMD6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[437]
Selenium	DM25CGV	N. A.	N. A.	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[437]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[70]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[485]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[437]
MG-132	DMKA2YS	N. A.	N. A.	Preclinical	[284]

Drug(s) Affected By Protein GREB1 (GREB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[225]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[486]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[487]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[46]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[486]
Nandrolone	DMFWKG1	Osteoporosis	FB83.0	Approved	[488]
Mestranol	DMG3F94	Contraception	QA21	Approved	[486]

Drug(s) Affected By Metalloreductase STEAP4 (STEAP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[489]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[189]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[46]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[46]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[169]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[40]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[490]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[491]

Drug(s) Affected By Sideroflexin-4 (SFXN4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[150]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[58]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[123]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[86]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[492]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[145]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[125]

Drug(s) Affected By Protein GOLM2 (GOLM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[493]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[125]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[133]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[347]

Drug(s) Affected By Spliceosome-associated protein CWC27 homolog (CWC27)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[135]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[237]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[494]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[348]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[301]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[87]

Drug(s) Affected By Teashirt homolog 1 (TSHZ1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[126]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[118]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[105]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[107]

Drug(s) Affected By Ribosomal protein eS27-like (RPS27L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[64]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[45]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[56]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[56]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[495]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[105]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]

Drug(s) Affected By Serologically defined colon cancer antigen 8 (SDCCAG8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[164]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[286]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[70]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[123]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[64]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[301]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[133]

Drug(s) Affected By Prostate tumor-overexpressed gene 1 protein (PTOV1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[64]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[70]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[186]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[496]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[145]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[125]

Drug(s) Affected By Protein HID1 (HID1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[121]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[173]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[145]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[141]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[258]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[133]
NAPQI	DM8F5LR	Autoimmune disease	4A40-4A45	Investigative	[497]

Drug(s) Affected By Periphilin-1 (PPHLN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[125]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[138]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[68]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[263]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[145]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[125]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[125]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[133]

Drug(s) Affected By Kinetochore scaffold 1 (KNL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[124]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[46]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[46]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]

Drug(s) Affected By Retinol dehydrogenase 11 (RDH11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[64]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[36]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[156]
Haloperidol	DM96SE0	Delirium		Approved	[236]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[123]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Bortezomib	DMNO38U	Leukemia		Approved	[41]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]

Drug(s) Affected By Disks large homolog 5 (DLG5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[150]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[36]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Promegestone	DMK4S8I	Gynecological disease	GA6Z	Approved	[498]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[68]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[146]

Drug(s) Affected By Septin-1 (SEPTIN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[348]

Drug(s) Affected By Protein NDRG1 (NDRG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[499]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[500]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[455]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[288]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[139]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[173]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]

Drug(s) Affected By Protein TMEPAI (PMEPA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[44]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[45]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[121]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[56]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[56]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[56]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[501]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]

Drug(s) Affected By Axin interactor, dorsalization-associated protein (AIDA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[69]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[260]

Drug(s) Affected By Endosome-associated-trafficking regulator 1 (ENTR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[136]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[141]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[125]

Drug(s) Affected By Regulator of microtubule dynamics protein 1 (RMDN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[36]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[70]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[141]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[294]
methyl p-hydroxybenzoate	DMO58UW	Discovery agent	N.A.	Investigative	[89]

Drug(s) Affected By Regulator of MON1-CCZ1 complex (RMC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[69]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[40]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[86]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[111]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[125]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[66]

Drug(s) Affected By Solute carrier family 45 member 3 (SLC45A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[502]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[140]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[136]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[447]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[503]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[373]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[145]

Drug(s) Affected By Protein LRATD2 (LRATD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[121]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[56]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[187]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[166]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[140]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[56]

Drug(s) Affected By Probable proton-coupled zinc antiporter SLC30A3 (SLC30A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[137]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[275]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[107]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[68]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[504]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[505]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[145]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[141]

Drug(s) Affected By Cell division control protein 6 homolog (CDC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[351]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[153]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[506]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[507]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[139]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[508]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[46]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[46]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]

Drug(s) Affected By Zinc phosphodiesterase ELAC protein 2 (ELAC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[147]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[123]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[68]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[509]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[485]

Drug(s) Affected By Mitochondrial nucleoid-associated protein 1 (MTNAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[107]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[86]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[125]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[87]

Drug(s) Affected By Spondin-2 (SPON2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[506]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[189]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[510]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[121]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[122]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[447]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[186]

Drug(s) Affected By Mediator of RNA polymerase II transcription subunit 18 (MED18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[45]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[511]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[286]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[86]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[512]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[87]

Drug(s) Affected By Fanconi anemia group J protein (BRIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[351]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[46]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[46]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[318]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[134]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[105]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[41]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]

Drug(s) Affected By N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[213]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[464]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[118]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[107]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[317]

Drug(s) Affected By Phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[133]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[33]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[123]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[173]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[138]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[107]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[513]

Drug(s) Affected By Breast cancer metastasis-suppressor 1 (BRMS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[64]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[33]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[64]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[263]

Drug(s) Affected By A-kinase-interacting protein 1 (AKIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[140]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[107]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[33]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[69]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[146]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[145]

Drug(s) Affected By Solute carrier family 35 member C2 (SLC35C2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bortezomib	DMNO38U	Leukemia		Approved	[41]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[145]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[141]
3-iodothyronamine	DM3L0F8	Discovery agent	N.A.	Investigative	[514]

Drug(s) Affected By Endophilin-B2 (SH3GLB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Bortezomib	DMNO38U	Leukemia		Approved	[41]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[107]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[69]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[186]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[141]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[125]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[259]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[149]

Drug(s) Affected By Sister chromatid cohesion protein PDS5 homolog B (PDS5B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[105]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[169]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[40]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[485]

Drug(s) Affected By Eukaryotic translation initiation factor 3 subunit K (EIF3K)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[515]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[64]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[263]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[141]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[125]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[125]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[294]

Drug(s) Affected By STE20/SPS1-related proline-alanine-rich protein kinase (STK39)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[483]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[47]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[275]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]

Drug(s) Affected By STEAP1 protein (STEAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[140]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[176]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[177]

Drug(s) Affected By Zinc finger transcription factor Trps1 (TRPS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[60]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[100]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[44]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[44]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[263]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[145]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[141]

Drug(s) Affected By Targeting protein for Xklp2 (TPX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[139]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[178]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[46]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[46]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[516]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[140]

Drug(s) Affected By Melanoma-associated antigen D2 (MAGED2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[64]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[107]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[64]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[145]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[141]

Drug(s) Affected By Serine/threonine-protein kinase ICK (CILK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[214]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]
Bortezomib	DMNO38U	Leukemia		Approved	[41]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[87]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[105]

Drug(s) Affected By Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[64]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[68]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[517]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[294]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[518]

Drug(s) Affected By START domain-containing protein 10 (STARD10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[101]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[70]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[145]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[141]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[519]

Drug(s) Affected By Ribosomal RNA-processing protein 7 homolog A (RRP7A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[64]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[118]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[105]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[261]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[64]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[520]

Drug(s) Affected By Spindlin-1 (SPIN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[63]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[123]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[70]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[269]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[263]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[145]

Drug(s) Affected By Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[521]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[133]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[522]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[523]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[456]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[524]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[525]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Androgen receptor (AR)	TTS64P2	ANDR_HUMAN	Inhibitor	[2]
Androgen receptor messenger RNA (AR mRNA)	TTKPW01	ANDR_HUMAN	Agonist	[3]
Progesterone receptor (PGR)	TTUV8G9	PRGR_HUMAN	Inhibitor	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
2-oxoglutarate dehydrogenase complex component E1 (OGDH)	OTHGTQWF	ODO1_HUMAN	Gene/Protein Processing	[4]
26S proteasome non-ATPase regulatory subunit 2 (PSMD2)	OT6HZHN7	PSMD2_HUMAN	Gene/Protein Processing	[5]
26S proteasome non-ATPase regulatory subunit 6 (PSMD6)	OTX59EGK	PSMD6_HUMAN	Gene/Protein Processing	[4]
26S proteasome regulatory subunit 4 (PSMC1)	OTLHD56E	PRS4_HUMAN	Gene/Protein Processing	[5]
26S proteasome regulatory subunit 6A (PSMC3)	OTSKT0JI	PRS6A_HUMAN	Gene/Protein Processing	[5]
3-hydroxyisobutyrate dehydrogenase, mitochondrial (HIBADH)	OTCMMMIZ	3HIDH_HUMAN	Gene/Protein Processing	[5]
4'-phosphopantetheine phosphatase (PANK4)	OTMLNEPU	PANK4_HUMAN	Gene/Protein Processing	[5]
4-trimethylaminobutyraldehyde dehydrogenase (ALDH9A1)	OTNWHUJ1	AL9A1_HUMAN	Gene/Protein Processing	[5]
5'-3' exoribonuclease 1	OTBBT1D8	XRN1_HUMAN	Gene/Protein Processing	[6]
A-kinase-interacting protein 1 (AKIP1)	OT7XPG27	AKIP1_HUMAN	Gene/Protein Processing	[4]

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