Details of Disease

Disease Name

Colorectal adenoma

colorectal adenoma; large bowel adenoma; adenoma of large bowel; adenoma of the large intestine; adenoma of the large bowel; large intestine adenoma; colorectum adenoma; adenoma of large intestine

Definition

An adenoma that arises from the colon or rectum. The group of colorectal adenomas includes tubular, villous, and tubulovillous adenomas, traditional serrated adenomas, sessile serrated adenomas/polyps, and familial adenomatous polyposis.|We follow NCIT in treating colorectal adenoma and large intestine adenoma as equivalent.

Disease Hierarchy

DISGROQ8: Digestive system adenoma

DISR1UCN: Colorectal neoplasm

DIS78ZEV: Adenoma

DISTSVHM: Colorectal adenoma

Disease Identifiers

MONDO ID

MONDO_0005484

UMLS CUI

C1302401

MedGen ID

224904

SNOMED CT ID

399432003

General Information of Disease (ID: DISTSVHM)

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 112 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ZSWIM7	OTMRLQYW	Limited	Unknown	[1]
AFAP1	OTR473H8	Limited	Genetic Variation	[39]
AXIN1	OTRGZGZ5	Limited	Autosomal dominant	[1]
BRF1	OTQC6DMG	Limited	Autosomal dominant	[1]
CACUL1	OT6P1ZVP	Limited	Genetic Variation	[40]
DSC2	OTODVH8K	Limited	Autosomal dominant	[1]
DSN1	OTHROI0H	Limited	Biomarker	[41]
E2F4	OTB3JFH4	Limited	Altered Expression	[42]
EEF1G	OTW7DH2F	Limited	Altered Expression	[43]
EXO1	OTI87RS5	Limited	Genetic Variation	[44]
FRZB	OTTO3DPY	Limited	Genetic Variation	[45]
IHH	OT1DWGXC	Limited	Biomarker	[46]
INTS6	OT6GDV46	Limited	Altered Expression	[47]
LIG3	OT48SKET	Limited	Biomarker	[48]
MACC1	OTV3DLX0	Limited	Altered Expression	[49]
MAP2K4	OTZPZX11	Limited	Biomarker	[50]
MUCL3	OTGAD3I0	Limited	Altered Expression	[51]
POFUT1	OTOBJZIT	Limited	Biomarker	[52]
PRSS50	OTC5JAVO	Limited	Altered Expression	[53]
RRM2B	OTE8GBUR	Limited	Genetic Variation	[54]
SEPTIN9	OT1VMRFQ	Limited	Posttranslational Modification	[55]
SKA3	OTLHEVJD	Limited	Altered Expression	[41]
TAS2R16	OT67HLNS	Limited	Genetic Variation	[56]
TAS2R38	OTX5MM36	Limited	Genetic Variation	[56]
TAS2R50	OTPRMVZW	Limited	Genetic Variation	[56]
TENT5A	OTSYF511	Limited	Altered Expression	[51]
TFDP2	OTKQFX5H	Limited	Altered Expression	[4]
TMEM54	OTPQEFR0	Limited	Genetic Variation	[40]
FTHL17	OTIWALXH	Disputed	Biomarker	[57]
ALX4	OTNS9A29	moderate	Posttranslational Modification	[58]
BRIP1	OT38QBD4	Moderate	Autosomal dominant	[1]
ACRBP	OT0MK3L1	Strong	Altered Expression	[59]
AGAP3	OT8C6PKL	Strong	Altered Expression	[60]
APC	OTKV0TIK	Strong	Genetic Variation	[61]
ARNT	OTMSIEZY	Strong	Genetic Variation	[62]
ATF1	OT251CI0	Strong	Genetic Variation	[9]
BAG1	OTRQNIA4	Strong	Biomarker	[63]
BHMT	OTYB6PXZ	Strong	Genetic Variation	[64]
BMP5	OTC0Y6E0	Strong	Genetic Variation	[9]
BOC	OTXBCY9W	Strong	Genetic Variation	[9]
CA8	OT9Y8GA8	Strong	Altered Expression	[65]
CCAR2	OTLUDG5T	Strong	Biomarker	[66]
CCND2	OTDULQF9	Strong	Genetic Variation	[9]
CHD1	OT9R9G0H	Strong	Genetic Variation	[9]
CHRDL2	OTJU2I5H	Strong	Genetic Variation	[9]
COL4A2	OTJK1LKN	Strong	Genetic Variation	[9]
CORO2A	OTVK7PK3	Strong	Altered Expression	[67]
COX2	OTTMVBJJ	Strong	Altered Expression	[68]
COX5A	OTP0961M	Strong	Genetic Variation	[69]
CPOX	OTIAY121	Strong	Genetic Variation	[69]
CTU1	OTNTM9D1	Strong	Biomarker	[70]
DDB2	OTO8HVVB	Strong	Altered Expression	[71]
DVL2	OTMNYNCM	Strong	Altered Expression	[72]
FJX1	OT8SVTSS	Strong	Altered Expression	[73]
FMN1	OT9CID5R	Strong	Genetic Variation	[9]
GDF1	OTZ1VRBH	Strong	Biomarker	[74]
GPX2	OTXI2NTI	Strong	Altered Expression	[75]
HGD	OTTKLQOO	Strong	Biomarker	[76]
HHIP	OT77RQYS	Strong	Genetic Variation	[9]
IFITM1	OTECO1G8	Strong	Altered Expression	[77]
KLF5	OT1ABI9N	Strong	Genetic Variation	[9]
LAMA5	OTIIXE4M	Strong	Genetic Variation	[9]
LAMC1	OTIG527N	Strong	Genetic Variation	[9]
LUC7L3	OTKDED8A	Strong	Biomarker	[78]
MAL	OTBM30SW	Strong	Posttranslational Modification	[79]
MPZ	OTAR2YXH	Strong	Biomarker	[21]
MTMR11	OTHL2O08	Strong	Biomarker	[78]
MUC6	OTPVL723	Strong	Biomarker	[20]
MYOD1	OTV2S79X	Strong	Biomarker	[80]
MYRF	OTKF6AEB	Strong	Genetic Variation	[9]
MZF1	OTMVZCPW	Strong	Genetic Variation	[9]
NPRL2	OTOB10MO	Strong	Altered Expression	[81]
NTHL1	OTPQXPT1	Strong	Genetic Variation	[82]
NXN	OT35N40G	Strong	Genetic Variation	[9]
OGN	OTKP5S4L	Strong	Altered Expression	[83]
OSBPL1A	OTQ33OQV	Strong	Biomarker	[84]
PLEKHG6	OTZWA27A	Strong	Genetic Variation	[9]
PMP22	OTXWYWCZ	Strong	Biomarker	[21]
PNKD	OT6G9UXN	Strong	Genetic Variation	[9]
POLD1	OTWO4UCJ	Strong	Genetic Variation	[85]
POLD3	OTEQEFQ2	Strong	Genetic Variation	[9]
POLE	OTFM3MMU	Strong	Genetic Variation	[85]
POU5F1B	OT0FKQ51	Strong	Genetic Variation	[9]
PRC1	OTHD0XS0	Strong	Biomarker	[74]
PRDX6	OTS8KC8A	Strong	Altered Expression	[86]
PREX1	OTUTPVA9	Strong	Genetic Variation	[9]
PTPRM	OTCEL6PN	Strong	Biomarker	[87]
RASSF2	OT2JHDO4	Strong	Posttranslational Modification	[88]
RETREG1	OTYOSLZX	Strong	Posttranslational Modification	[89]
RHPN2	OTTYWMF6	Strong	Genetic Variation	[9]
RIPOR3	OTHZ4RKK	Strong	Genetic Variation	[9]
RNH1	OT6EC79B	Strong	Biomarker	[74]
RRAS	OTBBF28C	Strong	Altered Expression	[90]
RTEL1	OTI3PJCT	Strong	Genetic Variation	[9]
SELENOP	OT02B8IR	Strong	Genetic Variation	[91]
SEMA3F	OTQFMS8S	Strong	Biomarker	[92]
SHC3	OT305NPA	Strong	Biomarker	[74]
SHMT1	OTIINA3J	Strong	Genetic Variation	[93]
SLIT3	OTU8MKEU	Strong	Altered Expression	[94]
TANC1	OTF6TZ8E	Strong	Genetic Variation	[9]
TEAD4	OTJS0T2B	Strong	Altered Expression	[95]
TET2	OTKKT03T	Strong	Genetic Variation	[9]
TMEM258	OTXSDU14	Strong	Genetic Variation	[9]
TOX2	OT7RZRVK	Strong	Genetic Variation	[9]
TRAK1	OTMQVYNP	Strong	Biomarker	[84]
TRIM21	OTA4UJCF	Strong	Biomarker	[96]
TTC22	OTFNNLI1	Strong	Genetic Variation	[9]
ATP2A3	OTFYDEES	Definitive	Altered Expression	[97]
DIDO1	OT9PB547	Definitive	Biomarker	[98]
EPS8	OTZ6ES6V	Definitive	Altered Expression	[99]
ING3	OTDIJXFP	Definitive	Altered Expression	[100]
RBM39	OTCMPTF9	Definitive	Biomarker	[98]
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⏷ Show the Full List of 112 DOT(s)

This Disease Is Related to 43 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
FZD10	TTP1S2F	Limited	Genetic Variation	[2]
GCLM	TTNFESW	Limited	Altered Expression	[3]
PTGDR2	TTQDMX5	Limited	Altered Expression	[4]
REG4	TTVZEHU	Limited	Altered Expression	[5]
BRIP1	TTZV7LJ	Moderate	Autosomal dominant	[1]
GSTA1	TT4P8DE	moderate	Genetic Variation	[6]
KLK5	TTULSEW	moderate	Altered Expression	[7]
BACE2	TT69DB8	Strong	Biomarker	[8]
BMP4	TTD3BSX	Strong	Genetic Variation	[9]
CD58	TT5KSBY	Strong	Biomarker	[10]
CDH3	TTARMD9	Strong	Genetic Variation	[9]
CEACAM3	TTPX7I5	Strong	Biomarker	[11]
CEACAM5	TTY6DTE	Strong	Biomarker	[12]
CYP1A2	TTS1DTU	Strong	Biomarker	[13]
CYP24A1	TT82UI1	Strong	Genetic Variation	[14]
CYP2C9	TTR40YJ	Strong	Genetic Variation	[15]
EIF5A2	TTH53G9	Strong	Altered Expression	[16]
FKBP5	TT0J5KQ	Strong	Genetic Variation	[9]
GREM1	TTOUZN5	Strong	Genetic Variation	[9]
GRM7	TT0I76D	Strong	Genetic Variation	[17]
LGR5	TTTSGRH	Strong	Altered Expression	[18]
LPAR1	TTQ6S1K	Strong	Genetic Variation	[9]
LRP1	TTF2V7I	Strong	Genetic Variation	[9]
MMP7	TTMTWOS	Strong	Genetic Variation	[19]
MUC5AC	TTEL90S	Strong	Biomarker	[20]
NR0B1	TTTK36V	Strong	Biomarker	[21]
ODC1	TTUMGNO	Strong	Genetic Variation	[22]
PIGU	TT2LHI6	Strong	Genetic Variation	[9]
POLB	TTA0XPV	Strong	Biomarker	[23]
SLC10A2	TTPI1M5	Strong	Genetic Variation	[24]
SLC23A1	TT6XAGK	Strong	Genetic Variation	[25]
SLC23A2	TTOP832	Strong	Biomarker	[25]
SLCO2A1	TTKVTQO	Strong	Genetic Variation	[9]
SMAD6	TTON5JB	Strong	Genetic Variation	[9]
SMAD7	TT0J32Z	Strong	Genetic Variation	[9]
SMAD9	TTX8EBV	Strong	Genetic Variation	[9]
TCF7L2	TT80QAL	Strong	Genetic Variation	[9]
TM6SF2	TTE1OHM	Strong	Genetic Variation	[26]
TRPC6	TTRBT3W	Strong	Genetic Variation	[9]
TYMS	TTP1UKZ	Strong	Genetic Variation	[27]
USP44	TTJLTNM	Strong	Posttranslational Modification	[28]
VDR	TTK59TV	Strong	Genetic Variation	[29]
FSCN1	TTTRS9B	Definitive	Altered Expression	[30]
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⏷ Show the Full List of 43 DTT(s)

This Disease Is Related to 3 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
SLC25A21	DT2UQYR	Limited	Genetic Variation	[31]
SLC25A26	DT8HR5O	Strong	Genetic Variation	[9]
SLC6A18	DTGQ7FH	Strong	Genetic Variation	[9]
------------------------------------------------------------------------------------

This Disease Is Related to 8 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
BAAT	DERA3OF	Limited	Biomarker	[32]
MTRR	DE6NIY9	Limited	Genetic Variation	[33]
ADH1C	DEM1HNL	Strong	Genetic Variation	[34]
AKR1A1	DED2FW3	Strong	Genetic Variation	[34]
CYP1A1	DE6OQ3W	Strong	Genetic Variation	[35]
HPGD	DEHKSC6	Strong	Biomarker	[36]
SULT1A1	DEYWLRK	Strong	Biomarker	[37]
UGT1A6	DESD26P	Strong	Genetic Variation	[38]
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⏷ Show the Full List of 8 DME(s)

References

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2	Genetic Aberration Analysis in Thai Colorectal Adenoma and Early-Stage Adenocarcinoma Patients by Whole-Exome Sequencing.Cancers (Basel). 2019 Jul 12;11(7):977. doi: 10.3390/cancers11070977.
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6	GSTP1 and GSTA1 polymorphisms interact with cruciferous vegetable intake in colorectal adenoma risk.Cancer Epidemiol Biomarkers Prev. 2005 Dec;14(12):2943-51. doi: 10.1158/1055-9965.EPI-05-0591.
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8	A novel aspartate protease gene, ALP56, is related to morphological features of colorectal adenomas.Int J Colorectal Dis. 2004 Jan;19(1):43-8. doi: 10.1007/s00384-003-0510-3. Epub 2003 Jun 11.
9	Discovery of common and rare genetic risk variants for colorectal cancer.Nat Genet. 2019 Jan;51(1):76-87. doi: 10.1038/s41588-018-0286-6. Epub 2018 Dec 3.
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11	Detection of mRNAs of carcinoembryonic antigen and nonspecific cross-reacting antigen genes in colorectal adenomas and carcinomas by in situ hybridization.Jpn J Cancer Res. 1990 Nov;81(11):1149-54. doi: 10.1111/j.1349-7006.1990.tb02527.x.
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13	Heterocyclic amine intake, smoking, cytochrome P450 1A2 and N-acetylation phenotypes, and risk of colorectal adenoma in a multiethnic population.Gut. 2013 Mar;62(3):416-22. doi: 10.1136/gutjnl-2011-300665. Epub 2012 May 24.
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17	Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas.Oncotarget. 2017 Oct 9;8(58):98623-98634. doi: 10.18632/oncotarget.21697. eCollection 2017 Nov 17.
18	LGR5 expression is regulated by EGF in early colorectal adenomas and governs EGFR inhibitor sensitivity.Br J Cancer. 2018 Feb 20;118(4):558-565. doi: 10.1038/bjc.2017.412. Epub 2017 Nov 16.
19	Genetic polymorphisms of MMP1, MMP3 and MMP7 gene promoter and risk of colorectal adenoma.BMC Cancer. 2006 Nov 24;6:270. doi: 10.1186/1471-2407-6-270.
20	Abnormal subcellular distribution of mature MUC2 and de novo MUC5AC mucins in adenomas of the rectum: immunohistochemical detection using non-VNTR antibodies to MUC2 and MUC5AC peptide.Glycoconj J. 2001 Nov-Dec;18(11-12):907-14. doi: 10.1023/a:1022204626604.
21	Glucocorticoids promote the development of azoxymethane and dextran sulfate sodium-induced colorectal carcinoma in mice.BMC Cancer. 2019 Jan 21;19(1):94. doi: 10.1186/s12885-019-5299-8.
22	Dietary polyamine intake and risk of colorectal adenomatous polyps.Am J Clin Nutr. 2012 Jul;96(1):133-41. doi: 10.3945/ajcn.111.030353. Epub 2012 May 30.
23	Genetic variation in base excision repair genes and the prevalence of advanced colorectal adenoma.Cancer Res. 2007 Feb 1;67(3):1395-404. doi: 10.1158/0008-5472.CAN-06-1390.
24	Effects of common haplotypes of the ileal sodium dependent bile acid transporter gene on the development of sporadic and familial colorectal cancer: a case control study.BMC Med Genet. 2008 Jul 21;9:70. doi: 10.1186/1471-2350-9-70.
25	Genetic variation in sodium-dependent vitamin C transporters SLC23A1 and SLC23A2 and risk of advanced colorectal adenoma.Nutr Cancer. 2008;60(5):652-9. doi: 10.1080/01635580802033110.
26	Association of TM6SF2 rs58542926 gene polymorphism with the risk of non-alcoholic fatty liver disease and colorectal adenoma in Chinese Han population.BMC Biochem. 2019 Feb 6;20(1):3. doi: 10.1186/s12858-019-0106-3.
27	Methionine synthase and thymidylate synthase gene polymorphisms and colorectal adenoma risk: the self defense forces study.Mol Carcinog. 2012 Oct;51 Suppl 1:E151-7. doi: 10.1002/mc.21895. Epub 2012 Mar 7.
28	Epigenetic inactivation of the candidate tumor suppressor USP44 is a frequent and early event in colorectal neoplasia.Epigenetics. 2014 Aug;9(8):1092-100. doi: 10.4161/epi.29222. Epub 2014 May 16.
29	Vitamin D receptor FokI polymorphism and the risks of colorectal cancer, inflammatory bowel disease, and colorectal adenoma.Sci Rep. 2018 Aug 27;8(1):12899. doi: 10.1038/s41598-018-31244-5.
30	Overexpression of fascin-1 in advanced colorectal adenocarcinoma: tissue microarray analysis of immunostaining scores with clinicopathological parameters.Dis Markers. 2007;23(3):153-60. doi: 10.1155/2007/685163.
31	Ornithine decarboxylase polymorphism modification of response to aspirin treatment for colorectal adenoma prevention.J Natl Cancer Inst. 2006 Oct 18;98(20):1494-500. doi: 10.1093/jnci/djj398.
32	BAT-26 and BAT-40 instability in colorectal adenomas and carcinomas and germline polymorphisms.Am J Pathol. 1999 Jun;154(6):1637-41. doi: 10.1016/S0002-9440(10)65418-1.
33	Low folate status, and MTHFR 677C?T and MTR 2756A?G polymorphisms associated with colorectal cancer risk in Thais: a case-control study.Nutr Res. 2019 Dec;72:80-91. doi: 10.1016/j.nutres.2019.10.008. Epub 2019 Oct 25.
34	Alcohol consumption, alcohol dehydrogenase 3 polymorphism, and colorectal adenomas.Cancer Epidemiol Biomarkers Prev. 2003 May;12(5):419-25.
35	CYP1A1, GSTM1, GSTT1 and NQO1 polymorphisms and colorectal adenomas in Japanese men.World J Gastroenterol. 2013 Jul 7;19(25):4023-30. doi: 10.3748/wjg.v19.i25.4023.
36	Chemopreventive Efficacy of the Cyclooxygenase-2 (Cox-2) Inhibitor, Celecoxib, Is Predicted by Adenoma Expression of Cox-2 and 15-PGDH.Cancer Epidemiol Biomarkers Prev. 2018 Jul;27(7):728-736. doi: 10.1158/1055-9965.EPI-17-0573. Epub 2018 May 16.
37	Effects of phenotypes in heterocyclic aromatic amine (HCA) metabolism-related genes on the association of HCA intake with the risk of colorectal adenomas.Cancer Causes Control. 2012 Sep;23(9):1429-42. doi: 10.1007/s10552-012-0017-8. Epub 2012 Jun 28.
38	The influence of UGT1A6 variants and aspirin use in a randomized trial of celecoxib for prevention of colorectal adenoma.Cancer Prev Res (Phila). 2012 Jan;5(1):61-72. doi: 10.1158/1940-6207.CAPR-11-0337. Epub 2011 Oct 26.
39	Prevalence of MYH germline mutations in Swiss APC mutation-negative polyposis patients.Int J Cancer. 2006 Apr 15;118(8):1937-40. doi: 10.1002/ijc.21470.
40	Coexistence of Colorectal Adenomas and Coronary Calcification in Asymptomatic Men and Women.J Clin Gastroenterol. 2018 Jul;52(6):508-514. doi: 10.1097/MCG.0000000000000824.
41	Over-expression of AURKA, SKA3 and DSN1 contributes to colorectal adenoma to carcinoma progression.Oncotarget. 2016 Jul 19;7(29):45803-45818. doi: 10.18632/oncotarget.9960.
42	ERK-associated changes in E2F4 phosphorylation, localization and transcriptional activity during mitogenic stimulation in human intestinal epithelial crypt cells.BMC Cell Biol. 2013 Aug 6;14:33. doi: 10.1186/1471-2121-14-33.
43	Overexpression of an elongation factor-1 gamma-hybridizing RNA in colorectal adenomas.Mol Carcinog. 1993;7(1):18-20. doi: 10.1002/mc.2940070104.
44	DNA repair gene polymorphisms and tobacco smoking in the risk for colorectal adenomas.Carcinogenesis. 2011 Jun;32(6):882-7. doi: 10.1093/carcin/bgr071. Epub 2011 Apr 18.
45	Genetic variants in frizzled-related protein (FRZB) and the risk of colorectal neoplasia.Cancer Causes Control. 2009 May;20(4):487-90. doi: 10.1007/s10552-008-9274-y. Epub 2008 Dec 9.
46	Opposite expression patterns of Sonic hedgehog and Indian hedgehog are associated with aberrant methylation status of their promoters in colorectal cancers.Pathology. 2010;42(6):553-9. doi: 10.3109/00313025.2010.508785.
47	Co-overexpression of DEAD box protein rck/p54 and c-myc protein in human colorectal adenomas and the relevance of their expression in cultured cell lines.Carcinogenesis. 2001 Dec;22(12):1965-70. doi: 10.1093/carcin/22.12.1965.
48	Genetic variation in the base excision repair pathway, environmental risk factors, and colorectal adenoma risk.PLoS One. 2013 Aug 12;8(8):e71211. doi: 10.1371/journal.pone.0071211. eCollection 2013.
49	MACC1 is related to colorectal cancer initiation and early-stage invasive growth.Am J Clin Pathol. 2013 Nov;140(5):701-7. doi: 10.1309/AJCPRH1H5RWWSXRB.
50	Downregulation of phosphorylated MKK4 is associated with a poor prognosis in colorectal cancer patients.Oncotarget. 2017 May 23;8(21):34352-34361. doi: 10.18632/oncotarget.16128.
51	Identification of a novel VNTR polymorphism in C6orf37 and its association with colorectal cancer risk in Chinese population.Clin Chim Acta. 2006 Jun;368(1-2):155-9. doi: 10.1016/j.cca.2005.12.043. Epub 2006 Mar 20.
52	Molecular characterization of colorectal adenomas reveals POFUT1 as a candidate driver of tumor progression.Int J Cancer. 2020 Apr 1;146(7):1979-1992. doi: 10.1002/ijc.32627. Epub 2019 Aug 30.
53	High expression of testes-specific protease 50 is associated with poor prognosis in colorectal carcinoma.PLoS One. 2011;6(7):e22203. doi: 10.1371/journal.pone.0022203. Epub 2011 Jul 12.
54	Novel genetic variations of the p53R2 gene in patients with colorectal adenoma and controls.World J Gastroenterol. 2005 Sep 7;11(33):5169-73. doi: 10.3748/wjg.v11.i33.5169.
55	The SEPT9 gene methylation assay is capable of detecting colorectal adenoma in opportunistic screening.Epigenomics. 2017 May;9(5):599-610. doi: 10.2217/epi-2016-0146. Epub 2017 May 4.
56	Variations in bitter-taste receptor genes, dietary intake, and colorectal adenoma risk.Nutr Cancer. 2013;65(7):982-90. doi: 10.1080/01635581.2013.807934. Epub 2013 Oct 1.
57	Exome capture sequencing of adenoma reveals genetic alterations in multiple cellular pathways at the early stage of colorectal tumorigenesis.PLoS One. 2013;8(1):e53310. doi: 10.1371/journal.pone.0053310. Epub 2013 Jan 2.
58	Aristaless-like homeobox-4 gene methylation is a potential marker for colorectal adenocarcinomas.Gastroenterology. 2006 Nov;131(5):1418-30. doi: 10.1053/j.gastro.2006.08.034. Epub 2006 Aug 18.
59	Cancer testis antigen OY-TES-1 expression and serum immunogenicity in colorectal cancer: its relationship to clinicopathological parameters.Int J Clin Exp Pathol. 2013 Nov 15;6(12):2835-45. eCollection 2013.
60	CRMP5-associated GTPase (CRAG) Is a Candidate Driver Gene for Colorectal Cancer Carcinogenesis.Anticancer Res. 2019 Jan;39(1):99-106. doi: 10.21873/anticanres.13084.
61	APC transcription studies and molecular diagnosis of familial adenomatous polyposis.Eur J Hum Genet. 2020 Jan;28(1):118-121. doi: 10.1038/s41431-019-0486-2. Epub 2019 Aug 5.
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