General Information of Drug Therapeutic Target (DTT) (ID: TTS1DTU)

DTT Name Cholesterol 25-hydroxylase
Synonyms
Cytochrome P450 1A2; Cytochrome P(3)450; Cytochrome P450 4; Cytochrome P450-P3; Cytochrome P-448; Hydroperoxy icosatetraenoate dehydratase; CYPIA2; Cytochrome P-450d; Cytochrome P450-D; Cytochrome P450-P3
Gene Name CYP1A2
BioChemical Class
Single Protein
UniProt ID
CP1A2_HUMAN
TTD ID
TE0029
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKN
PHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDG
QSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELM
AGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFP
ILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGN
LIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLS
DRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPEL
WEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLE
FSVPPGVKVDLTPIYGLTMKHARCEHVQARLRFSIN
Function
A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens.

The Drug-Metabolizing Enzyme (DME) Role of This DTT

DTT DME Name Cytochrome P450 1A2 (CYP1A2) DME Info
Gene Name CYP1A2
191 Approved Drug(s) Metabolized by This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acenocoumarol DMH75KV Thrombosis DB61-GB90 Approved [1]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [2]
Albendazole DMYZ57N Echinococcus granulosus infectious disease Approved [3]
Alosetron DML2A03 Diarrhea-predominant irritable bowel syndrome DD91.01 Approved [4]
Aminophylline DML2NIB Bronchial asthma CA23 Approved [5]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [6]
Amitriptyline DMK7F9S Depression 6A70-6A7Z Approved [7]
Anagrelide DMSQ8MD Thrombocythemia 3B63 Approved [8]
Apixaban DM89JLN Thrombosis DB61-GB90 Approved [9]
Apremilast DMTWS9E Psoriasis vulgaris EA90 Approved [10]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [11]
ARRY-162 DM1P6FR Melanoma 2C30 Approved [12]
Asenapine DMSQZE2 Schizophrenia 6A20 Approved [13]
Axitinib DMGVH6N Renal cell carcinoma 2C90 Approved [14]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [15]
Azelastine DMXTMBJ Allergic conjunctivitis 9A60.02 Approved [16]
Bamifylline DMXLHYN Chronic obstructive pulmonary disease CA22 Approved [17]
Bendamustine hydrochloride DMFH15Z leukaemia 2A60-2B33 Approved [18]
Benzyl alcohol DMBVYDI Head and body lice 1G00.0 Approved [19]
Betaxolol DM6EUL5 Hypertension BA00-BA04 Approved [20]
Bortezomib DMNO38U Leukemia Approved [21]
Bromazepam DMY9TCW Anxiety disorder 6B00-6B0Z Approved [22]
Caffeine DMKBJWP Allergic rhinitis CA08.0 Approved [1]
Capsaicin DMGMF6V Back pain ME84.Z Approved [23]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [24]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [25]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [26]
Chlorzoxazone DMCYVDT Acute pain MG31 Approved [27]
Cilostazol DMZMSCT Intermittent claudication BD40.00 Approved [28]
Cinacalcet DMCX0K3 Hyperparathyroidism 5A51 Approved [28]
Cinnarizine DM7U5QJ Meniere disease AB31.0 Approved [29]
Clenbuterol DMCKYZ5 Chronic breathing disorder 7A4Z Approved [30]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [31]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [32]
Clopidogrel DMOL54H Acute coronary syndrome BA41 Approved [33]
Clozapine DMFC71L Schizophrenia 6A20 Approved [34]
Conjugated Estrogens DMLT0E1 Dyspareunia GA12 Approved [35]
Cyclobenzaprine DM1YBRM Depression 6A70-6A7Z Approved [36]
Dacarbazine DMNPZL4 Adenocarcinoma 2D40 Approved [37]
Dapagliflozin DM28UJG Non-insulin dependent diabetes 5A11 Approved [38]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [39]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [40]
Desipramine DMT2FDC Attention deficit hyperactivity disorder 6A05.Z Approved [41]
Deutetrabenazine DMUPFLI Huntington disease 8A01.10 Approved [42]
Dexmedetomidine DM93L4X Irritability MB24 Approved [43]
Diazepam DM08E9O Alcohol withdrawal Approved [44]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [45]
Dihydralazine DMZIXU9 Hypertension BA00-BA04 Approved [46]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [47]
Disopyramide DM5SYZP Long QT syndrome BC65.0 Approved [48]
Domperidone DMBDPY0 Gastrointestinal disease DE2Z Approved [49]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [50]
Doxepin DMPI98T Anxiety Approved [51]
Doxofylline DMEDKZH Asthma CA23 Approved [17]
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [52]
Duloxetine DM9BI7M Depression 6A70-6A7Z Approved [53]
E-2007 DMJDYNQ Diabetic neuropathy 8C0Z Approved [54]
Efavirenz DMC0GSJ Human immunodeficiency virus infection 1C62 Approved [55]
Eltrombopag DMOGFIX Thrombocytopenia 3B64 Approved [56]
Enasidenib DM8QXOC N. A. N. A. Approved [57]
Ergotamine DMKR3C5 Cluster headache 8A81.0 Approved [58]
Erlotinib DMCMBHA Adrenal gland neoplasm Approved [39]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [59]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [60]
Estradiol Acetate DM07U2A Hormone replacement therapy 8E01 Approved [61]
Estradiol Cypionate DM27Z5T Hormone replacement therapy 8E01 Approved [62]
Estradiol Valerate DM8MC6O Hormone replacement therapy 8E01 Approved [62]
Estrone DM5T6US Acne vulgaris ED80 Approved [63]
Ethanol DMDRQZU Chronic pain MG30 Approved [41]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [64]
Etoricoxib DM6A4NW Rheumatoid arthritis FA20 Approved [65]
Fexinidazole DMOYE70 African trypanosomiasis 1F51 Approved [66]
Flecainide DMSQDLE Tachyarrhythmias BC71 Approved [67]
Flunarizine DMZU5JP Migraine 8A80 Approved [31]
Flunitrazepam DMGR5Z3 Insomnia 7A00-7A0Z Approved [41]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [68]
Fluoxetine DM3PD2C Bipolar depression Approved [69]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [70]
Frovatriptan DM7RE8P Migraine 8A80 Approved [58]
Granisetron DMIUW25 Malignant glioma 2A00.0 Approved [71]
Grepafloxacin DMGLX0T Chronic bronchitis CA20.1 Approved [72]
Griseofulvin DMK54YG Onychomycosis EE12.1 Approved [73]
Guanabenz DM5QWEL High blood pressure BA00 Approved [74]
Haloperidol DM96SE0 Delirium Approved [75]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [76]
Hexobarbital DMQ314B Anaesthesia 9A78.6 Approved [77]
Idebenone DMQFDRC Cognitive impairment 6D71 Approved [78]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [79]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [80]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [41]
Ipriflavone DM0IO13 Osteoporosis FB83.0 Approved [81]
Istradefylline DM20VSK Parkinson disease 8A00.0 Approved [82]
Leflunomide DMR8ONJ Arthritis FA20 Approved [74]
Levobupivacaine DM783CH Anaesthesia 9A78.6 Approved [83]
Lidocaine DML4ZOT Anaesthesia 9A78.6 Approved [74]
Lofexidine DM1WXA6 Heroin and opiate withdrawal 6C43 Approved [84]
Lomefloxacin DMVRH9C Bacterial infection 1A00-1C4Z Approved [85]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [86]
Lorcaserin DMG6OYJ Obesity 5B81 Approved [87]
Loxapine DM8AI9U Bipolar disorder 6A60 Approved [88]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [89]
Luvox DMJKROX Anxiety disorder 6B00-6B0Z Approved [90]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [91]
Maprotiline DMPWB7T Depression 6A70-6A7Z Approved [92]
Melatonin DMKWFBT Depression 6A70-6A7Z Approved [93]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [94]
Mephenytoin DM5UGDK Epilepsy 8A60-8A68 Approved [95]
Methadone DMTW6IU Advanced cancer 2A00-2F9Z Approved [96]
Methoxyflurane DML0RAE Anaesthesia 9A78.6 Approved [97]
Methyldopa DM5I621 Hypertension BA00-BA04 Approved [98]
Metoclopramide DMFA5MY Nausea MD90 Approved [99]
Mexiletine DMCTE9R Ventricular tachycardia BC71 Approved [100]
Mianserin DMVKA4O Depression 6A70-6A7Z Approved [101]
Mirtazapine DML53ZJ Depression 6A70-6A7Z Approved [102]
MLN9708 DMCMETN Amyloidosis 5D00 Approved [103]
Momelotinib DMF98Q0 Myelofibrosis 2A20.2 Approved [104]
Nabumetone DMAT2XH Osteoarthritis FA00-FA05 Approved [105]
Naproxen DMZ5RGV Bursitis Approved [106]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [107]
Nifedipine DMSVOZT Angina pectoris BA40 Approved [108]
Norethindrone acetate DMDGCQP N. A. N. A. Approved [109]
Norfloxacin DMIZ6W2 Acute gonococcal cervicitis Approved [69]
Nortriptyline DM4KDYJ Depression 6A70-6A7Z Approved [110]
Olanzapine DMPFN6Y Bipolar depression Approved [111]
Ondansetron DMOTQ1I Chemotherapy-induced nausea MD90 Approved [112]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [113]
Oxtriphylline DMLHSE3 Cough MD12 Approved [114]
Pantoprazole DMSVOCZ Gastrinoma 2C10.1 Approved [41]
Paroxetine DM5PVQE Anxiety disorder 6B00-6B0Z Approved [115]
Pazopanib DMF57DM N. A. N. A. Approved [116]
Pentamidine DMHZJCG African trypanosomiasis 1F51 Approved [117]
Pentoxifylline DMU3DNC Alcoholic hepatitis DB94.1 Approved [118]
Perazine DM2AOTZ Psychotic disorder 6A20-6A25 Approved [119]
Perphenazine DMA4MRX Schizophrenia 6A20 Approved [120]
Pimozide DMW83TP Schizophrenia 6A20 Approved [121]
Pirfenidone DM6VZFQ Idiopathic pulmonary fibrosis CB03.4 Approved [122]
Pomalidomide DMTGBAX Plasma cell myeloma 2A83.1 Approved [123]
Praziquantel DMOU1PK Flatworm infection 1F70-1F86 Approved [117]
Primaquine DMWQ16I Malaria 1F40-1F45 Approved [117]
Procarbazine DMIK367 Hodgkin lymphoma 2B30 Approved [124]
Proguanil DMBL79I Malaria 1F40-1F45 Approved [95]
Promazine DMZAL7W Acute intermittent hepatic porphyria 5C58.11 Approved [125]
Propafenone DMPIBJK Tachyarrhythmias BC71 Approved [126]
Propentofylline propionate DM6JQ2I Alzheimer disease 8A20 Approved [17]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [127]
Propranolol DM79NTF Angina pectoris BA40 Approved [74]
Pyrazinamide DM4IF32 Meningeal tuberculosis Approved [128]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [129]
Ramelteon DM7IW9J Insomnia 7A00-7A0Z Approved [130]
Ramosetron DMH7GN8 Diarrhea-predominant irritable bowel syndrome DD91.01 Approved [131]
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [132]
Rasagiline DM3WKQ4 Parkinson disease 8A00.0 Approved [133]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [134]
Riluzole DMECBWN Amyotrophic lateral sclerosis 8B60.0 Approved [135]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [136]
Roflumilast DMPGHY8 Asthma CA23 Approved [137]
Ropinirole DMA6S1D Parkinson disease 8A00.0 Approved [138]
Ropivacaine DMSPJG2 Anaesthesia 9A78.6 Approved [139]
Rucaparib DM9PVX8 Ovarian cancer 2C73 Approved [140]
Selegiline Hydrochloride DM3VR1L Parkinson disease 8A00.0 Approved [141]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [142]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [143]
Stiripentol DMMSDOY Dravet syndrome 8A61.11 Approved [144]
Tacrine DM51FY6 Alzheimer disease 8A20 Approved [74]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [145]
Tasimelteon DMLOQ1V Insomnia 7A00-7A0Z Approved [146]
Tegafur DM31ZQM Solid tumour/cancer 2A00-2F9Z Approved [41]
Terbinafine DMI6HUW Fungal infection 1F29-1F2F Approved [147]
Theobromine DMM8D3F Asthma CA23 Approved [148]
Theophylline DMRJFN9 Bronchitis CA20 Approved [149]
Thiabendazole DM7YCK3 Ascariasis 1F62 Approved [74]
Thiothixene DMDINC4 Schizophrenia 6A20 Approved [150]
Tizanidine DMR2IQ4 Spasm MB47.3 Approved [74]
Tocainide DMYNMDP Ventricular arrhythmias BC71 Approved [151]
Tolperisone DMA2GHJ Muscle spasm MB47.3 Approved [152]
Triamterene DM2HU9I Congestive heart failure BD10 Approved [153]
TRICLABENDAZOLE DMPWGBR Helminth infection 1F90.0 Approved [154]
Trifluoperazine DMKBYWI Anxiety Approved [155]
Ulipristal DMBNI20 Contraception QA21 Approved [156]
Verapamil DMA7PEW Angina pectoris BA40 Approved [157]
Vincamine DMK1ZOR Cerebrovascular disease 8B2Z Approved [158]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [159]
Voxilaprevir DMAI83D N. A. N. A. Approved [160]
Warfarin DMJYCVW Atrial fibrillation BC81.3 Approved [161]
Zileuton DMVRIC2 Allergic asthma CA23.0 Approved [74]
Zolmitriptan DM1IB4Q Migraine 8A80 Approved [44]
Zolpidem DMWOSKJ Insomnia 7A00-7A0Z Approved [162]
ZOTEPINE DMF3VXA Anxiety disorder 6B00-6B0Z Approved [163]
Icotinib hydrochloride DM5GFIK Non-small-cell lung cancer 2C25.Y Registered [164]
Aminophenazone DMY2AH1 N. A. N. A. Phase 4 [41]
Pentifylline DMQY873 N. A. N. A. Phase 4 [17]
------------------------------------------------------------------------------------
⏷ Show the Full List of 191 Approved Drug(s)
19 Clinical Trial Drug(s) Metabolized by This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
5-methoxypsoralen DME2A8X Psoriasis vulgaris EA90 Phase 3 [165]
Bicifadine DM42GP9 Chronic low back pain MG30.02 Phase 3 [166]
Pracinostat DMTD7AB Acute myeloid leukaemia 2A60 Phase 3 [167]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [168]
Sumanirole DMYHV17 Parkinson disease 8A00.0 Phase 3 [169]
TKI258 DMYLT67 Renal cell carcinoma 2C90 Phase 3 [170]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [171]
Sarizotan DMH7IPW Rett syndrome LD90.4 Phase 2/3 [172]
BCP-13498 DM2BO9W N. A. N. A. Phase 2 [173]
Famitinib DMSFWT7 Solid tumour/cancer 2A00-2F9Z Phase 2 [174]
GTS-21 DMEN5KA Parkinson disease 8A00.0 Phase 2 [175]
Lisofylline DMVU9X1 Type-1 diabetes 5A10 Phase 2 [176]
PYRAZOLOACRIDINE DMSOPAU Colorectal cancer 2B91.Z Phase 2 [128]
Vadimezan DMK7CYX Solid tumour/cancer 2A00-2F9Z Phase 2 [177]
H3B-6545 DMIFCY2 Breast cancer 2C60-2C65 Phase 1/2 [178]
TG02 DMZFIGQ Anaplastic astrocytoma 2A00.0 Phase 1/2 [179]
MLN8054 DMUANF3 Solid tumour/cancer 2A00-2F9Z Phase 1 [180]
NSC-38348 DM96RD5 N. A. N. A. Phase 1 [17]
Xanthine DMFBOQ7 Apnea MD11.0 Phase 1 [181]
------------------------------------------------------------------------------------
⏷ Show the Full List of 19 Clinical Trial Drug(s)
9 Discontinued Drug(s) Metabolized by This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Agomelatine DMXYA5K Major depressive disorder 6A70.3 Withdrawn from market [182]
Dexfenfluramine DMJ7YDS Obesity 5B81 Withdrawn from market [183]
Phenacetin DMRQAM0 Analgesia MB40.8 Withdrawn from market [184]
Temafloxacin DM3TON2 Bacterial infection 1A00-1C4Z Withdrawn from market [85]
Bropirimine DMMT1YQ Virus infection 1A24-1D9Z Discontinued in Phase 3 [185]
Benzydamine DMEQL9U Chemotherapy or radiotherapy-induced mucositis DA42-DA60 Discontinued in Phase 2 [41]
Nemifitide DM6VP9U Major depressive disorder 6A70.3 Discontinued in Phase 2 [186]
Mofarotene DMKHEQL Solid tumour/cancer 2A00-2F9Z Discontinued in Phase 1 [187]
VR-776 DMFQWNI Premature ejaculation HA03.0Z Discontinued in Phase 1 [188]
------------------------------------------------------------------------------------
⏷ Show the Full List of 9 Discontinued Drug(s)
12 Investigative Drug(s) Metabolized by This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
6-Benzyloxy-9H-purin-2-ylamine DMFI7A8 Discovery agent N.A. Investigative [189]
Acefylline DMVTSM8 N. A. N. A. Investigative [17]
Acriflavinium chloride DMYZJ5B N. A. N. A. Investigative [190]
cyamemazine DMZ6YPV Discovery agent N.A. Investigative [191]
Fenethylline DM34V5W N. A. N. A. Investigative [17]
Guajazulen DMGYMW4 N. A. N. A. Investigative [192]
Hypoxanthine DMLSABI Discovery agent N.A. Investigative [181]
Imipramine oxide DMZKABS N. A. N. A. Investigative [193]
NSC-6113 DMX2YH7 N. A. N. A. Investigative [194]
PARAOXON DMN4ZKC Discovery agent N.A. Investigative [195]
Phenazone DMCE985 Discovery agent N.A. Investigative [1]
[3H]estrone-3-sulphate DMGPF0N Discovery agent N.A. Investigative [196]
------------------------------------------------------------------------------------
⏷ Show the Full List of 12 Investigative Drug(s)

References

1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 PharmGKB summary: pathways of acetaminophen metabolism at the therapeutic versus toxic doses. Pharmacogenet Genomics. 2015 Aug;25(8):416-26.
3 Cytochrome P450 1A1/2 induction by antiparasitic drugs: dose-dependent increase in ethoxyresorufin O-deethylase activity and mRNA caused by quinine, primaquine and albendazole in HepG2 cells. Eur J Clin Pharmacol. 2002 Nov;58(8):537-42.
4 Optimizing outcomes with alosetron hydrochloride in severe diarrhea-predominant irritable bowel syndrome. Therap Adv Gastroenterol. 2010 May;3(3):165-72.
5 Lack of effect of olanzapine on the pharmacokinetics of a single aminophylline dose in healthy men. Pharmacotherapy. 1998 Nov-Dec;18(6):1237-48.
6 Role of desethylamiodarone in the anticoagulant effect of concurrent amiodarone and warfarin therapy. J Cardiovasc Pharmacol Ther. 2001 Oct;6(4):363-7.
7 The genetic profiles of CYP1A1, CYP1A2 and CYP2E1 enzymes as susceptibility factor in xenobiotic toxicity in Turkish population. Saudi Pharm J. 2017 Feb;25(2):294-297.
8 Open-label, dose-titration and continuation study to assess efficacy, safety, and pharmacokinetics of anagrelide in treatment-nae Japanese patients with essential thrombocythemia. Int J Hematol. 2013 Mar;97(3):360-8.
9 Apixaban. Hosp Pharm. 2013 Jun;48(6):494-509.
10 Apremilast (Otezla): a new oral treatment for adults with psoriasis and psoriatic arthritis. P T. 2015 Aug;40(8):495-500.
11 Cytochrome P450 3A4 is the major enzyme involved in the metabolism of the substance P receptor antagonist aprepitant. Drug Metab Dispos. 2004 Nov;32(11):1287-92.
12 FDA Label of Binimetinib. The 2020 official website of the U.S. Food and Drug Administration.
13 Asenapine review, part I: chemistry, receptor affinity profile, pharmacokinetics and metabolism. Expert Opin Drug Metab Toxicol. 2014 Jun;10(6):893-903.
14 Clinical pharmacology of axitinib. Clin Pharmacokinet. 2013 Sep;52(9):713-25.
15 Brassica vegetables increase and apiaceous vegetables decrease cytochrome P450 1A2 activity in humans: changes in caffeine metabolite ratios in response to controlled vegetable diets. Carcinogenesis. 2000 Jun;21(6):1157-62.
16 In vitro identification of the human cytochrome P-450 enzymes involved in the N-demethylation of azelastine. Drug Metab Dispos. 1999 Aug;27(8):942-6.
17 PharmGKB summary: caffeine pathway. Pharmacogenet Genomics. 2012 May;22(5):389-95.
18 Pharmacokinetic and pharmacodynamic profile of bendamustine and its metabolites. Cancer Chemother Pharmacol. 2015 Jun;75(6):1143-54.
19 Cytochrome P450 isozymes responsible for the metabolism of toluene and styrene in human liver microsomes. Xenobiotica. 1997 Jul;27(7):657-65.
20 Drugs that may have potential CYP1A2 interactions.
21 Human metabolism of the proteasome inhibitor bortezomib: identification of circulating metabolites. Drug Metab Dispos. 2005 Jun;33(6):771-7.
22 Selective serotonin reuptake inhibitors and CNS drug interactions. A critical review of the evidence. Clin Pharmacokinet. 1997 Dec;33(6):454-71.
23 Metabolism of capsaicin by cytochrome P450 produces novel dehydrogenated metabolites and decreases cytotoxicity to lung and liver cells. Chem Res Toxicol. 2003 Mar;16(3):336-49.
24 Interactions between antiepileptics and second-generation antipsychotics. Expert Opin Drug Metab Toxicol. 2012 Mar;8(3):311-34.
25 Pharmacokinetic interactions study between carvedilol and some antidepressants in rat liver microsomes - a comparative study. Med Pharm Rep. 2019 Apr;92(2):158-164.
26 Functional polymorphisms of the cytochrome P450 1A2 (CYP1A2) gene and prolonged QTc interval in schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2007 Aug 15;31(6):1297-302.
27 Inhibitory monoclonal antibodies to human cytochrome P450 1A2: analysis of phenacetin O-deethylation in human liver. Pharmacogenetics. 1998 Oct;8(5):375-82.
28 Effects of CYP3A inhibition on the metabolism of cilostazol. Clin Pharmacokinet. 1999;37 Suppl 2:61-8.
29 Insights into the substrate specificity, inhibitors, regulation, and polymorphisms and the clinical impact of human cytochrome P450 1A2. AAPS J. 2009 Sep;11(3):481-94.
30 Beta-adrenergic receptor modulation of the LPS-mediated depression in CYP1A activity in astrocytes. Biochem Pharmacol. 2005 Mar 1;69(5):741-50.
31 Oxidative metabolism of flunarizine and cinnarizine by microsomes from B-lymphoblastoid cell lines expressing human cytochrome P450 enzymes. Biol Pharm Bull. 1996 Nov;19(11):1511-4.
32 CYP2D6 mediates 4-hydroxylation of clonidine in vitro: implication for pregnancy-induced changes in clonidine clearance. Drug Metab Dispos. 2010 Sep;38(9):1393-6.
33 Clinical pharmacokinetics and pharmacodynamics of clopidogrel. Clin Pharmacokinet. 2015 Feb;54(2):147-66.
34 Metabolic drug interactions with newer antipsychotics: a comparative review. Basic Clin Pharmacol Toxicol. 2007 Jan;100(1):4-22.
35 Effect of conjugated equine estrogens on oxidative metabolism in middle-aged and elderly postmenopausal women. J Clin Pharmacol. 2006 Nov;46(11):1299-307.
36 Identification of human liver cytochrome P450 isoforms involved in the in vitro metabolism of cyclobenzaprine. Drug Metab Dispos. 1996 Jul;24(7):786-91.
37 Study on mesenchymal stem cells mediated enzyme-prodrug gene CYP1A2 targeting anti-tumor effect. Zhonghua Xue Ye Xue Za Zhi. 2009 Oct;30(10):667-71.
38 Clinical pharmacokinetics and pharmacodynamics of dapagliflozin, a selective inhibitor of sodium-glucose co-transporter type 2. Clin Pharmacokinet. 2014 Jan;53(1):17-27.
39 Clinical pharmacokinetics of tyrosine kinase inhibitors. Cancer Treat Rev. 2009 Dec;35(8):692-706.
40 The effect of new lipophilic chelators on the activities of cytosolic reductases and P450 cytochromes involved in the metabolism of anthracycline antibiotics: studies in vitro. Physiol Res. 2004;53(6):683-91.
41 Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448.
42 FDA Label of Deutetrabenazine. The 2020 official website of the U.S. Food and Drug Administration.
43 Predominant role of peripheral catecholamines in the stress-induced modulation of CYP1A2 inducibility by benzo(alpha)pyrene. Basic Clin Pharmacol Toxicol. 2008 Jan;102(1):35-44.
44 In vitro metabolism of zolmitriptan in rat cytochromes induced with beta-naphthoflavone and the interaction between six drugs and zolmitriptan. Chem Biol Interact. 2003 Dec 15;146(3):263-72.
45 Metabolism and metabolic inhibition of xanthotoxol in human liver microsomes. Evid Based Complement Alternat Med. 2016;2016:5416509.
46 Mechanism-based inactivation of cytochrome P450s 1A2 and 3A4 by dihydralazine in human liver microsomes. Chem Res Toxicol. 1999 Oct;12(10):1028-32.
47 Effects of polyunsaturated fatty acids on prostaglandin synthesis and cyclooxygenase-mediated DNA adduct formation by heterocyclic aromatic amines in human adenocarcinoma colon cells. Mol Carcinog. 2004 Jul;40(3):180-8.
48 Species difference in stereoselective involvement of CYP3A in the mono-N-dealkylation of disopyramide. Xenobiotica. 2001 Feb;31(2):73-83.
49 Characterization of human cytochrome P450 enzymes catalyzing domperidone N-dealkylation and hydroxylation in vitro. Br J Clin Pharmacol. 2004 Sep;58(3):277-87.
50 Modulation of CYP1A2 enzyme activity by indoleamines: inhibition by serotonin and tryptamine. Pharmacogenetics. 1998 Jun;8(3):251-8.
51 The N-demethylation of the doxepin isomers is mainly catalyzed by the polymorphic CYP2C19. Pharm Res. 2002 Jul;19(7):1034-7.
52 Principal drug-metabolizing enzyme systems in L1210 leukemia sensitive or resistant to BCNU in vivo. Leuk Res. 1994 Nov;18(11):829-35.
53 Duloxetine: clinical pharmacokinetics and drug interactions. Clin Pharmacokinet. 2011 May;50(5):281-94.
54 Perampanel (Fycompa): a review of clinical efficacy and safety in epilepsy. P T. 2016 Nov;41(11):683-698.
55 CYP2B6 genotype-dependent inhibition of CYP1A2 and induction of CYP2A6 by the antiretroviral drug efavirenz in healthy volunteers. Clin Transl Sci. 2019 Nov;12(6):657-666.
56 Eltrombopag for use in children with immune thrombocytopenia. Blood Adv. 2018 Feb 27;2(4):454-461.
57 FDA Label of Enasidenib. The 2020 official website of the U.S. Food and Drug Administration.
58 Frovatriptan: a review of drug-drug interactions. Headache. 2002 Apr;42 Suppl 2:S63-73.
59 Comparative studies of in vitro inhibition of cytochrome P450 3A4-dependent testosterone 6beta-hydroxylation by roxithromycin and its metabolites, troleandomycin, and erythromycin. Drug Metab Dispos. 1998 Nov;26(11):1053-7.
60 Cytochrome P450 1A2 (CYP1A2) activity and risk factors for breast cancer: a cross-sectional study. Breast Cancer Res. 2004;6(4):R352-65.
61 Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms. Endocrinology. 2003 Aug;144(8):3382-98.
62 Inhibition of the human liver microsomal and human cytochrome P450 1A2 and 3A4 metabolism of estradiol by deployment-related and other chemicals. Drug Metab Dispos. 2006 Sep;34(9):1606-14.
63 A transgenic mouse expressing human CYP1A2 in the pancreas. Biochem Pharmacol. 2000 Sep 15;60(6):857-63.
64 Effects of morin on the pharmacokinetics of etoposide in rats. Biopharm Drug Dispos. 2007 Apr;28(3):151-6.
65 Role of human liver cytochrome P4503A in the metabolism of etoricoxib, a novel cyclooxygenase-2 selective inhibitor. Drug Metab Dispos. 2001 Jun;29(6):813-20.
66 Fexinidazole--a new oral nitroimidazole drug candidate entering clinical development for the treatment of sleeping sickness. PLoS Negl Trop Dis. 2010 Dec 21;4(12):e923.
67 Flecainide: current status and perspectives in arrhythmia management. World J Cardiol. 2015 Feb 26;7(2):76-85.
68 Roles of cytochromes P450 1A2, 2A6, and 2C8 in 5-fluorouracil formation from tegafur, an anticancer prodrug, in human liver microsomes. Drug Metab Dispos. 2000 Dec;28(12):1457-63.
69 Clinically significant psychotropic drug-drug interactions in the primary care setting. Curr Psychiatry Rep. 2012 Aug;14(4):376-90.
70 Metabolism of the antiandrogenic drug (Flutamide) by human CYP1A2. Drug Metab Dispos. 1997 Nov;25(11):1298-303.
71 Heterogeneity in systemic availability of ondansetron and granisetron following oral administration. Drug Metab Dispos. 1999 Jan;27(1):110-2.
72 Quantitative prediction of drug interactions caused by CYP1A2 inhibitors and inducers. Clin Pharmacokinet. 2016 Aug;55(8):977-90.
73 Kinetic mechanism of the activation of human plasminogen by streptokinase. Biochemistry. 1975 Oct 7;14(20):4459-65.
74 Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development. Curr Med Chem. 2009;16(31):4066-218.
75 In vitro characterization of the metabolism of haloperidol using recombinant cytochrome p450 enzymes and human liver microsomes. Drug Metab Dispos. 2001 Dec;29(12):1638-43.
76 In vitro investigation of cytochrome P450-mediated metabolism of dietary flavonoids. Food Chem Toxicol. 2002 May;40(5):609-16.
77 Cytochrome P450 isozymes involved in propranolol metabolism in human liver microsomes. The role of CYP2D6 as ring-hydroxylase and CYP1A2 as N-desisopropylase. Drug Metab Dispos. 1994 Nov-Dec;22(6):909-15.
78 Pharmacokinetic evaluation of idebenone. Expert Opin Drug Metab Toxicol. 2010 Nov;6(11):1437-44.
79 The effect of apigenin on pharmacokinetics of imatinib and its metabolite N-desmethyl imatinib in rats. Biomed Res Int. 2013;2013:789184.
80 Reappraisal of human CYP isoforms involved in imipramine N-demethylation and 2-hydroxylation: a study using microsomes obtained from putative extensive and poor metabolizers of S-mephenytoin and eleven recombinant human CYPs. J Pharmacol Exp Ther. 1997 Jun;281(3):1199-210.
81 Characterization of cytochrome P450s mediating ipriflavone metabolism in human liver microsomes. Xenobiotica. 2007 Mar;37(3):246-59.
82 Effects of rifampin on the pharmacokinetics of a single dose of istradefylline in healthy subjects. J Clin Pharmacol. 2018 Feb;58(2):193-201.
83 Pharmacokinetics of levobupivacaine after caudal epidural administration in infants less than 3 months of age. Br J Anaesth. 2005 Oct;95(4):524-9.
84 The Drugs.com International Drug Name Database: Lofexidine
85 Inhibitory potency of quinolone antibacterial agents against cytochrome P450IA2 activity in vivo and in vitro. Antimicrob Agents Chemother. 1992 May;36(5):942-8.
86 Metabolism of loratadine and further characterization of its in vitro metabolites. Drug Metab Lett. 2009 Aug;3(3):162-70.
87 Identification of human cytochrome P450 and flavin-containing monooxygenase enzymes involved in the metabolism of lorcaserin, a novel selective human 5-hydroxytryptamine 2C agonist. Drug Metab Dispos. 2012 Apr;40(4):761-71.
88 In vitro identification of the human cytochrome p450 enzymes involved in the oxidative metabolism of loxapine. Biopharm Drug Dispos. 2011 Oct;32(7):398-407.
89 Clinical pharmacology of lumiracoxib: a selective cyclo-oxygenase-2 inhibitor. Clin Pharmacokinet. 2005;44(12):1247-66.
90 Effect of fluvoxamine on the pharmacokinetics of roflumilast and roflumilast N-oxide. Clin Pharmacokinet. 2007;46(7):613-22.
91 Malathion bioactivation in the human liver: the contribution of different cytochrome p450 isoforms. Drug Metab Dispos. 2005 Mar;33(3):295-302.
92 Cytochrome P450 enzymes contributing to demethylation of maprotiline in man. Pharmacol Toxicol. 2002 Mar;90(3):144-9.
93 Multiple P450 substrates in a single run: rapid and comprehensive in vitro interaction assay. Eur J Pharm Sci. 2005 Jan;24(1):123-32.
94 Rat hepatic CYP1A1 and CYP1A2 induction by menadione. Toxicol Lett. 2005 Feb 15;155(2):253-8.
95 Comparison of (S)-mephenytoin and proguanil oxidation in vitro: contribution of several CYP isoforms. Br J Clin Pharmacol. 1999 Aug;48(2):158-67.
96 Methadone--metabolism, pharmacokinetics and interactions. Pharmacol Res. 2004 Dec;50(6):551-9.
97 Identification of cytochrome P450 2E1 as the predominant enzyme catalyzing human liver microsomal defluorination of sevoflurane, isoflurane, and methoxyflurane. Anesthesiology. 1993 Oct;79(4):795-807.
98 Lack of interaction between amiodarone and mexiletine in cardiac arrhythmia patients. J Clin Pharmacol. 2002 Mar;42(3):342-6.
99 Metoclopramide is metabolized by CYP2D6 and is a reversible inhibitor, but not inactivator, of CYP2D6. Xenobiotica. 2014 Apr;44(4):309-319.
100 Inhibition of human liver cytochrome P-450 1A2 by the class IB antiarrhythmics mexiletine, lidocaine, and tocainide. J Pharmacol Exp Ther. 1999 May;289(2):853-8.
101 Identification of human cytochrome P450 isoforms involved in the stereoselective metabolism of mianserin enantiomers. J Pharmacol Exp Ther. 1996 Jul;278(1):21-30.
102 Impact of the CYP2D6 ultrarapid metabolizer genotype on mirtazapine pharmacokinetics and adverse events in healthy volunteers. J Clin Psychopharmacol. 2004 Dec;24(6):647-52.
103 Phase 1/2 trial of ixazomib, cyclophosphamide and dexamethasone in patients with previously untreated symptomatic multiple myeloma. Blood Cancer J. 2018 Jul 30;8(8):70.
104 Pharmacokinetics and disposition of momelotinib revealed a disproportionate human metabolite-resolution for clinical development. Drug Metab Dispos. 2018 Mar;46(3):237-247.
105 A predominate role of CYP1A2 for the metabolism of nabumetone to the active metabolite, 6-methoxy-2-naphthylacetic acid, in human liver microsomes. Drug Metab Dispos. 2009 May;37(5):1017-24.
106 Involvement of multiple cytochrome P450 isoforms in naproxen O-demethylation. Eur J Clin Pharmacol. 1997;52(4):293-8.
107 Roles of CYP2A6 and CYP2B6 in nicotine C-oxidation by human liver microsomes. Arch Toxicol. 1999 Mar;73(2):65-70.
108 Inhibition of human cytochrome P450 enzymes by 1,4-dihydropyridine calcium antagonists: prediction of in vivo drug-drug interactions. Eur J Clin Pharmacol. 2000 Feb-Mar;55(11-12):843-52.
109 Identification of the human cytochrome P450 enzymes involved in the in vitro biotransformation of lynestrenol and norethindrone. J Steroid Biochem Mol Biol. 2008 May;110(1-2):56-66.
110 Hydroxylation and demethylation of the tricyclic antidepressant nortriptyline by cDNA-expressed human cytochrome P-450 isozymes. Drug Metab Dispos. 1997 Jun;25(6):740-4.
111 Interactions between the cytochrome P450 system and the second-generation antipsychotics. J Psychiatry Neurosci. 2003 Mar;28(2):99-112.
112 Effects of serotonin-3 receptor antagonists on cytochrome P450 activities in human liver microsomes. Biol Pharm Bull. 2006 Sep;29(9):1931-5.
113 The influence of metabolic gene polymorphisms on urinary 1-hydroxypyrene concentrations in Chinese coke oven workers. Sci Total Environ. 2007 Aug 1;381(1-3):38-46.
114 PharmGKB summary: very important pharmacogene information for CYP1A2. Pharmacogenet Genomics. 2012 Jan;22(1):73-7.
115 CYP1A2 genetic polymorphisms are associated with treatment response to the antidepressant paroxetine. Pharmacogenomics. 2010 Nov;11(11):1535-43.
116 Pazopanib, a new therapy for metastatic soft tissue sarcoma. Expert Opin Pharmacother. 2013 May;14(7):929-35.
117 Identification of human cytochrome P(450)s that metabolise anti-parasitic drugs and predictions of in vivo drug hepatic clearance from in vitro data. Eur J Clin Pharmacol. 2003 Sep;59(5-6):429-42.
118 Cytochrome P450 isozymes involved in lisofylline metabolism to pentoxifylline in human liver microsomes. Drug Metab Dispos. 1997 Dec;25(12):1354-8.
119 Perazine as a potent inhibitor of human CYP1A2 but not CYP3A4. Pol J Pharmacol. 2002 Jul-Aug;54(4):407-10.
120 Effect of antipsychotic drugs on human liver cytochrome P-450 (CYP) isoforms in vitro: preferential inhibition of CYP2D6. Drug Metab Dispos. 1999 Sep;27(9):1078-84.
121 Identification and characterization of human cytochrome P450 isoforms interacting with pimozide. J Pharmacol Exp Ther. 1998 May;285(2):428-37.
122 Risk of clinically relevant pharmacokinetic-based drug-drug interactions with drugs approved by the U.S. Food and Drug Administration between 2013 and 2016. Drug Metab Dispos. 2018 Jun;46(6):835-845.
123 Population pharmacokinetics of pomalidomide. J Clin Pharmacol. 2015 May;55(5):563-72.
124 In vitro and in vivo evidence for the formation of methyl radical from procarbazine: a spin-trapping study. Carcinogenesis. 1992 May;13(5):799-805.
125 Contribution of human cytochrome p-450 isoforms to the metabolism of the simplest phenothiazine neuroleptic promazine. Br J Pharmacol. 2003 Apr;138(8):1465-74.
126 Inhibitory effects of antiarrhythmic drugs on phenacetin O-deethylation catalysed by human CYP1A2. Br J Clin Pharmacol. 1998 Apr;45(4):361-8.
127 Inhibition of cytochrome P450 2E1 by propofol in human and porcine liver microsomes. Biochem Pharmacol. 2002 Oct 1;64(7):1151-6.
128 The metabolism of pyrazoloacridine (NSC 366140) by cytochromes p450 and flavin monooxygenase in human liver microsomes. Clin Cancer Res. 2004 Feb 15;10(4):1471-80.
129 The roles of cytochrome P450 3A4 and 1A2 in the 3-hydroxylation of quinine in vivo. Clin Pharmacol Ther. 1999 Nov;66(5):454-60.
130 Metabolism of ramelteon in human liver microsomes and correlation with the effect of fluvoxamine on ramelteon pharmacokinetics. Drug Metab Dispos. 2010 Aug;38(8):1381-91.
131 Ondansetron, ramosetron, or palonosetron: which is a better choice of antiemetic to prevent postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy? Anesth Essays Res. 2011 Jul-Dec;5(2):182-6.
132 Comparative in vitro and in vivo inhibition of cytochrome P450 CYP1A2, CYP2D6, and CYP3A by H2-receptor antagonists. Clin Pharmacol Ther. 1999 Apr;65(4):369-76.
133 Rasagiline (TVP-1012): a new selective monoamine oxidase inhibitor for Parkinson's disease. Am J Geriatr Pharmacother. 2006 Dec;4(4):330-46.
134 Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes. Drug Metab Dispos. 2003 Apr;31(4):421-31.
135 Association between CYP1A2 activity and riluzole clearance in patients with amyotrophic lateral sclerosis. Br J Clin Pharmacol. 2005 Mar;59(3):310-3.
136 Rofecoxib is a potent inhibitor of cytochrome P450 1A2: studies with tizanidine and caffeine in healthy subjects. Br J Clin Pharmacol. 2006 Sep;62(3):345-57.
137 Effect of steady-state enoxacin on single-dose pharmacokinetics of roflumilast and roflumilast N-oxide. J Clin Pharmacol. 2011 Apr;51(4):586-93.
138 Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67.
139 Metabolism of ropivacaine in humans is mediated by CYP1A2 and to a minor extent by CYP3A4: an interaction study with fluvoxamine and ketoconazole as in vivo inhibitors. Clin Pharmacol Ther. 1998 Nov;64(5):484-91.
140 Rucaparib: the past, present, and future of a newly approved PARP inhibitor for ovarian cancer. Onco Targets Ther. 2017 Jun 19;10:3029-3037.
141 Comparative studies on the cytochrome p450-associated metabolism and interaction potential of selegiline between human liver-derived in vitro systems. Drug Metab Dispos. 2003 Sep;31(9):1093-102.
142 The selective serotonin reuptake inhibitor sertraline: its profile and use in psychiatric disorders. CNS Drug Rev. 2001 Spring;7(1):1-24.
143 Ontogeny and sorafenib metabolism. Clin Cancer Res. 2012 Oct 15;18(20):5788-95.
144 Stiripentol. Expert Opin Investig Drugs. 2005 Jul;14(7):905-11.
145 Endoxifen and other metabolites of tamoxifen inhibit human hydroxysteroid sulfotransferase 2A1 (hSULT2A1). Drug Metab Dispos. 2014 Nov;42(11):1843-50.
146 Clinical assessment of drug-drug interactions of tasimelteon, a novel dual melatonin receptor agonist. J Clin Pharmacol. 2015 Sep;55(9):1004-11.
147 Multiple cytochrome P-450s involved in the metabolism of terbinafine suggest a limited potential for drug-drug interactions. Drug Metab Dispos. 1999 Sep;27(9):1029-38.
148 Cytochrome P450 isoform selectivity in human hepatic theobromine metabolism. Br J Clin Pharmacol. 1999 Mar;47(3):299-305.
149 Association between common CYP1A2 polymorphisms and theophylline metabolism in non-smoking healthy volunteers. Basic Clin Pharmacol Toxicol. 2013 Apr;112(4):257-63.
150 In vitro analysis of factors influencing CYP1A2 expression as potential determinants of interindividual variation. Pharmacol Res Perspect. 2017 Mar 2;5(2):e00299.
151 The effect of tocainide on theophylline metabolism. Br J Clin Pharmacol. 1993 Apr;35(4):437-40.
152 Identification of metabolic pathways involved in the biotransformation of tolperisone by human microsomal enzymes. Drug Metab Dispos. 2003 May;31(5):631-6.
153 Rate-limiting biotransformation of triamterene is mediated by CYP1A2. Int J Clin Pharmacol Ther. 2005 Jul;43(7):327-34.
154 In vitro drug-drug interaction potential of sulfoxide and/or sulfone metabolites of albendazole, triclabendazole, aldicarb, methiocarb, montelukast and ziprasidone. Drug Metab Lett. 2018;12(2):101-116.
155 Psychotropic Medications Metabolized by Cytochromes P450 (CYP) 1A2 Enzyme and Relevant Drug Interactions: Review of Articles
156 The clinical pharmacology and pharmacokinetics of ulipristal acetate for the treatment of uterine fibroids. Reprod Sci. 2015 Apr;22(4):476-83.
157 Identification of P450 enzymes involved in metabolism of verapamil in humans. Naunyn Schmiedebergs Arch Pharmacol. 1993 Sep;348(3):332-7.
158 Characterization of human cytochrome P450 isoenzymes involved in the metabolism of vinorelbine. Fundam Clin Pharmacol. 2005 Oct;19(5):545-53.
159 Carotenoids as regulators for inter-species difference in cytochrome P450 1A expression and activity in ungulates and rats. Food Chem Toxicol. 2010 Nov;48(11):3201-8.
160 Management of Unique Populations with HCV Infection
161 Metabolism of R- and S-warfarin by CYP2C19 into four hydroxywarfarins. Drug Metab Lett. 2012 Sep 1;6(3):157-64.
162 Adverse reactions to zolpidem: case reports and a review of the literature. Prim Care Companion J Clin Psychiatry. 2010;12(6). pii: PCC.09r00849.
163 Identification of cytochrome P450 enzymes involved in the metabolism of zotepine, an antipsychotic drug, in human liver microsomes. Xenobiotica. 1999 Mar;29(3):217-29.
164 Metabolic pathway of icotinib in vitro: the differential roles of CYP3A4, CYP3A5, and CYP1A2 on potential pharmacokinetic drug-drug interaction. J Pharm Sci. 2018 Apr;107(4):979-983.
165 Cytochrome P450 CYP1B1 interacts with 8-methoxypsoralen (8-MOP) and influences psoralen-ultraviolet A (PUVA) sensitivity. PLoS One. 2013 Sep 23;8(9):e75494.
166 In vitro metabolism of the analgesic bicifadine in the mouse, rat, monkey, and human. Drug Metab Dispos. 2007 Dec;35(12):2232-41.
167 Preclinical metabolism and disposition of SB939 (Pracinostat), an orally active histone deacetylase inhibitor, and prediction of human pharmacokinetics. Drug Metab Dispos. 2011 Dec;39(12):2219-32.
168 Involvement of cytochrome P450 1A2 in the biotransformation of trans-resveratrol in human liver microsomes. Biochem Pharmacol. 2004 Aug 15;68(4):773-82.
169 Psychological effects of dopamine agonist treatment in patients with hyperprolactinemia and prolactin-secreting adenomas. Eur J Endocrinol. 2019 Jan 1;180(1):31-40.
170 A drug-drug interaction study to assess the effect of the CYP1A2 inhibitor fluvoxamine on the pharmacokinetics of dovitinib (TKI258) in patients with advanced solid tumors. Cancer Chemother Pharmacol. 2018 Jan;81(1):73-80.
171 Differential mechanisms for the inhibition of human cytochrome P450 1A2 by apigenin and genistein. J Biochem Mol Toxicol. 2010 Jul-Aug;24(4):230-4.
172 In vitro characterization of sarizotan metabolism: hepatic clearance, identification and characterization of metabolites, drug-metabolizing enzyme identification, and evaluation of cytochrome p450 inhibition. Drug Metab Dispos. 2010 Jun;38(6):905-16.
173 Acetaminophen activation by human liver cytochromes P450IIE1 and P450IA2. Arch Biochem Biophys. 1989 Jun;271(2):270-83.
174 Metabolism and bioactivation of famitinib, a novel inhibitor of receptor tyrosine kinase, in cancer patients. Br J Pharmacol. 2013 Apr;168(7):1687-706.
175 Metabolism and disposition of GTS-21, a novel drug for Alzheimer's disease. Xenobiotica. 1999 Jul;29(7):747-62.
176 Physiologically based modeling of lisofylline pharmacokinetics following intravenous administration in mice. Eur J Drug Metab Pharmacokinet. 2016 Aug;41(4):403-12.
177 Preclinical factors affecting the interindividual variability in the clearance of the investigational anti-cancer drug 5,6-dimethylxanthenone-4-acetic acid. Biochem Pharmacol. 2003 Jun 1;65(11):1853-65.
178 Nonclinical pharmacokinetics and in vitro metabolism of H3B-6545, a novel selective ERalpha covalent antagonist (SERCA). Cancer Chemother Pharmacol. 2019 Jan;83(1):151-160.
179 Preclinical metabolism and pharmacokinetics of SB1317 (TG02), a potent CDK/JAK2/FLT3 inhibitor. Drug Metab Lett. 2012 Mar;6(1):33-42.
180 MLN8054 and Alisertib (MLN8237): discovery of selective oral aurora A inhibitors. ACS Med Chem Lett. 2015 Apr 22;6(6):630-4.
181 Rapid determination of five probe drugs and their metabolites in human plasma and urine by liquid chromatography/tandem mass spectrometry: application to cytochrome P450 phenotyping studies. Rapid Commun Mass Spectrom. 2004;18(23):2921-33.
182 Does celecoxib inhibit agomelatine metabolism via CYP2C9 or CYP1A2? Drug Des Devel Ther. 2018 Jul 11;12:2169-2172.
183 Appetite suppressant drugs as inhibitors of human cytochromes P450: in vitro inhibition of P450-2D6 by D- and L-fenfluramine, but not phentermine. J Clin Psychopharmacol. 1998 Aug;18(4):338-41.
184 CYP2A13 metabolizes the substrates of human CYP1A2, phenacetin, and theophylline. Drug Metab Dispos. 2007 Mar;35(3):335-9.
185 Human biotransformation of bropirimine. Characterization of the major bropirimine oxidative metabolites formed in vitro. Drug Metab Dispos. 1998 Oct;26(10):1048-51.
186 Antidepressants: Past, Present and Future. Edited by Sheldon H. Preskorn Christina Y. Stanga John P. Feighner Ruth Ross. Page: 574.
187 Metabolism of mofarotene in hepatocytes and liver microsomes from different species. Comparison with in vivo data and evaluation of the cytochrome P450 isoenzymes involved in human biotransformation. Drug Metab Dispos. 1995 Oct;23(10):1051-7.
188 Erythromycin interaction with risperidone or clomipramine in an adolescent. J Child Adolesc Psychopharmacol. 1996 Summer;6(2):133-8.
189 Human liver oxidative metabolism of O6-benzylguanine. Biochem Pharmacol. 1995 Oct 26;50(9):1385-9.
190 Activation of the antitumor agent aminoflavone (NSC 686288) is mediated by induction of tumor cell cytochrome P450 1A1/1A2. Mol Pharmacol. 2002 Jul;62(1):143-53.
191 Characterization of human cytochrome P450 enzymes involved in the metabolism of cyamemazine. Eur J Pharm Sci. 2007 Dec;32(4-5):357-66.
192 The influence of the sparteine/debrisoquine genetic polymorphism on the disposition of dexfenfluramine. Br J Clin Pharmacol. 1996 Apr;41(4):311-7.
193 Major pathway of imipramine metabolism is catalyzed by cytochromes P-450 1A2 and P-450 3A4 in human liver. Mol Pharmacol. 1993 May;43(5):827-32.
194 Coleman J., Cox A. and Cowley N. (2011). Side Effects of Drugs Annual. Elsevier.
195 Diazinon, chlorpyrifos and parathion are metabolised by multiple cytochromes P450 in human liver. Toxicology. 2006 Jul 5;224(1-2):22-32.
196 Role of polymorphic human cytochrome P450 enzymes in estrone oxidation. Cancer Epidemiol Biomarkers Prev. 2006 Mar;15(3):551-8.