General Information of Drug (ID: DMG814N)

Drug Name
Saquinavir Drug Info
Synonyms
Fortovase; Invirase; ROC; SQV; Saguinavir; Ro 318959; Fortovase (TN); Fortovase(TM); Invirase (TN); Ro 31-8959; Invirase(TM)(monomesylate); Ro-31-8959; Saquinavir (JAN/USP/INN); QNC-ASN-HPH-DIQ-NTB; CIS-N-TERT-BUTYL-DECAHYDRO-2-[2(R)-HYDROXY-4-PHENYL-3(S)-[[N-2-QUINOLYLCARBONYL-L-ASPARAGINYL]AMINO]BUTYL]-(4AS)-ISOQUINOLINE-3(S)-CARBOXAMIDE; (2S)-N-[(2S,3R)-4-[(3S,4aS,8aS)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1-phenylbutan-2-yl]-2-(quinoline-2-carbonylamino)butanediamide; (2s)-N-[(2s,3r)-4-[(2s,3s,4as,8as)-3-(Tert-Butylcarbamoyl)-3,4,4a,5,6,7,8,8a-Octahydro-1h-Isoquinolin-2-Yl]-3-Hydroxy-1-Phenyl-Butan-2-Yl]-2-(Quinolin-2-Ylcarbonylamino)butanediamide
Indication
Disease Entry ICD 11 Status REF
Human immunodeficiency virus infection 1C62 Approved [1]
Therapeutic Class
Anti-HIV Agents
Cross-matching ID
PubChem CID
441243
ChEBI ID
CHEBI:63621
CAS Number
CAS 127779-20-8
TTD Drug ID
DMG814N
VARIDT Drug ID
DR00309
INTEDE Drug ID
DR1462
ACDINA Drug ID
D00615

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [18]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [19]
Atazanavir DMSYRBX Human immunodeficiency virus infection 1C62 Approved [20]
Amprenavir DMLMXE0 Human immunodeficiency virus infection 1C62 Approved [21]
Darunavir DMN3GCH Human immunodeficiency virus infection 1C62 Approved [22]
Tipranavir DM8HJX6 Human immunodeficiency virus infection 1C62 Approved [23]
Fosamprenavir DM4W9B3 Human immunodeficiency virus infection 1C62 Approved [24]
BI 201335 DM3MXT8 Hepatitis C virus infection 1E51.1 Phase 3 [25]
BMS 650032 DMQI43G Hepatitis C virus infection 1E51.1 Phase 2 [26]
Danoprevir DM20MDU Hepatitis C virus infection 1E51.1 Phase 2 [27]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [28]
Methotrexate DM2TEOL Anterior urethra cancer Approved [29]
Folic Acid DMEMBJC Colorectal carcinoma Approved [30]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [31]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [32]
Verapamil DMA7PEW Angina pectoris BA40 Approved [33]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [34]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [35]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [36]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [37]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [38]
Methotrexate DM2TEOL Anterior urethra cancer Approved [39]
Folic Acid DMEMBJC Colorectal carcinoma Approved [40]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [41]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [42]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [43]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [44]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [45]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [46]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [47]
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Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [33]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [48]
Methotrexate DM2TEOL Anterior urethra cancer Approved [49]
Folic Acid DMEMBJC Colorectal carcinoma Approved [50]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [49]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [49]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [51]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [49]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [52]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [53]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [54]
Methotrexate DM2TEOL Anterior urethra cancer Approved [55]
Folic Acid DMEMBJC Colorectal carcinoma Approved [56]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [57]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [58]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [59]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [60]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [59]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [61]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [62]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [63]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [7]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [64]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [65]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [64]
Pravastatin DM6A0X7 Adult acute monocytic leukemia Approved [66]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [67]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [68]
Cerivastatin DMXCM7H Hyperlipidaemia 5C80 Approved [69]
PITAVASTATIN CALCIUM DM1UJO0 Dyslipidemia 5C80-5C81 Approved [66]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [70]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [71]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [72]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [73]
PITAVASTATIN CALCIUM DM1UJO0 Dyslipidemia 5C80-5C81 Approved [74]
Rosuvastatin DMMIQ7G Arteriosclerosis BD40 Approved [75]
Enalapril DMNFUZR Congestive heart failure BD10 Approved [76]
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [77]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [78]
Labetalol DMK8U72 Hypertension BA00-BA04 Approved [79]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [80]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [81]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [82]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [83]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [84]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [85]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [86]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [87]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [81]
Verapamil DMA7PEW Angina pectoris BA40 Approved [88]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [89]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [90]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [91]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [84]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [88]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [92]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [93]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [94]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [95]
Propranolol DM79NTF Angina pectoris BA40 Approved [96]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 3A5 (CYP3A5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [97]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [98]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [99]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [100]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [101]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [102]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [103]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [104]
Verapamil DMA7PEW Angina pectoris BA40 Approved [105]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [100]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 3A7 (CYP3A7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [106]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [100]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [100]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [100]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [107]
Verapamil DMA7PEW Angina pectoris BA40 Approved [108]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [100]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [100]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [100]
Metronidazole DMTIVEN Abscess Approved [109]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Trospium chloride DM32XZT Discovery agent N.A. Approved [110]
Hydroxyurea DMOQVU9 Chronic myelogenous leukaemia 2A20.0 Approved [111]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [112]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [113]
Testosterone enanthate DMB6871 N. A. N. A. Approved [114]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [115]
Cholecalciferol DMGU74E Adult acute monocytic leukemia Approved [116]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [117]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [118]
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [119]
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Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [120]
Riluzole DMECBWN Amyotrophic lateral sclerosis 8B60.0 Approved [121]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [122]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [123]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [124]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [125]
Ethacrynic acid DM60QMR Edema MG29 Approved [126]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [127]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [128]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [129]
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Drug(s) Affected By Bile salt export pump (ABCB11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [13]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [130]
Glipizide DMZA5PQ Diabetic complication 5A2Y Approved [130]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [131]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [13]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [130]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [132]
Gefitinib DM15F0X Colon adenocarcinoma Approved [13]
Drospirenone DM1A9W3 Acne vulgaris ED80 Approved [133]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [13]
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Drug(s) Affected By Albumin (ALB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [134]
Sulfamethoxazole DMB08GE Acute otitis media AB00 Approved [135]
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [136]
Diazepam DM08E9O Alcohol withdrawal Approved [137]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [138]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [139]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [140]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [141]
Methotrexate DM2TEOL Anterior urethra cancer Approved [142]
Quercetin DM3NC4M Obesity 5B81 Approved [143]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gefitinib DM15F0X Colon adenocarcinoma Approved [16]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [144]
Indapamide DMGN1PW Edema MG29 Approved [16]
Bortezomib DMNO38U Leukemia Approved [145]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [16]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [118]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [146]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [147]
acetaldehyde DMJFKG4 Discovery agent N.A. Investigative [148]
⏷ Show the Full List of 9 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [149]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [150]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [151]
Etretinate DM2CZFA Keratosis ED56 Approved [152]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [153]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [154]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [155]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [156]
Quercetin DM3NC4M Obesity 5B81 Approved [157]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [158]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [150]
Quercetin DM3NC4M Obesity 5B81 Approved [159]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [150]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [160]
Pyrazinamide DM4IF32 Meningeal tuberculosis Approved [161]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [162]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [163]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [150]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [164]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [165]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gefitinib DM15F0X Colon adenocarcinoma Approved [16]
Selenium DM25CGV N. A. N. A. Approved [166]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [16]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [167]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [168]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [169]
Repaglinide DM5SXUV Diabetic complication 5A2Y Approved [16]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [170]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [171]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [172]
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Drug(s) Affected By Caspase-9 (CASP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [173]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [174]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [175]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [176]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [177]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [178]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [179]
Meloxicam DM2AR7L Arthritis FA20 Approved [180]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [181]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [182]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [144]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [183]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [184]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [185]
Sulforaphane DMQY3L0 Skin disease EA00-EM0Z Investigative [186]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Human immunodeficiency virus Protease (HIV PR) TT5FNQT POL_HV1B1 Inhibitor [2]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Multidrug resistance-associated protein 2 (ABCC2) DTFI42L MRP2_HUMAN Substrate [3]
Organic anion transporting polypeptide 1A2 (SLCO1A2) DTE2B1D SO1A2_HUMAN Substrate [4]
Multidrug resistance-associated protein 1 (ABCC1) DTSYQGK MRP1_HUMAN Substrate [5]
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [6]
Organic anion transporting polypeptide 1B1 (SLCO1B1) DT3D8F0 SO1B1_HUMAN Substrate [7]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [8]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) Main DME DE4LYSA CP3A4_HUMAN Substrate [9]
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Substrate [10]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Substrate [11]
Cytochrome P450 3A7 (CYP3A7) DERD86B CP3A7_HUMAN Substrate [11]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Albumin (ALB) OTVMM513 ALBU_HUMAN Protein Interaction/Cellular Processes [12]
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Gene/Protein Processing [13]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Protein Interaction/Cellular Processes [14]
Cyclic AMP-dependent transcription factor ATF-6 alpha (ATF6) OTAFHAVI ATF6A_HUMAN Gene/Protein Processing [14]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Gene/Protein Processing [15]
Endoplasmic reticulum chaperone BiP (HSPA5) OTFUIRAO BIP_HUMAN Gene/Protein Processing [14]
HLA class I histocompatibility antigen, alpha chain F (HLA-F) OT76CM19 HLAF_HUMAN Gene/Protein Processing [16]
HLA class II histocompatibility antigen, DO alpha chain (HLA-DOA) OTZE5Q7R DOA_HUMAN Gene/Protein Processing [16]
Solute carrier organic anion transporter family member 1A2 (SLCO1A2) OTO70C5O SO1A2_HUMAN Regulation of Drug Effects [4]
Synaptic vesicle glycoprotein 2B (SV2B) OTAO5WIU SV2B_HUMAN Drug Response [17]

References

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2 PL-100, a novel HIV-1 protease inhibitor displaying a high genetic barrier to resistance: an in vitro selection study. J Med Virol. 2008 Dec;80(12):2053-63.
3 Evidence for two interacting ligand binding sites in human multidrug resistance protein 2 (ATP binding cassette C2). J Biol Chem. 2003 Jun 27;278(26):23538-44.
4 Human organic anion-transporting polypeptide OATP-A (SLC21A3) acts in concert with P-glycoprotein and multidrug resistance protein 2 in the vectorial transport of Saquinavir in Hep G2 cells. Mol Pharm. 2004 Jan 12;1(1):49-56.
5 Direct evidence that saquinavir is transported by multidrug resistance-associated protein (MRP1) and canalicular multispecific organic anion transporter (MRP2). Antimicrob Agents Chemother. 2002 Nov;46(11):3456-62.
6 Nicotine and cotinine increases the brain penetration of saquinavir in rat. J Neurochem. 2010 Dec;115(6):1495-507.
7 Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev. 2011 Mar;63(1):157-81.
8 Predicting P-glycoprotein effects on oral absorption: correlation of transport in Caco-2 with drug pharmacokinetics in wild-type and mdr1a(-/-) mice in vivo. Pharm Res. 2004 May;21(5):819-26.
9 Effect of saquinavir-ritonavir on cytochrome P450 3A4 activity in healthy volunteers using midazolam as a probe. Pharmacotherapy. 2009 Oct;29(10):1175-81.
10 Inhibition of desipramine hydroxylation (Cytochrome P450-2D6) in vitro by quinidine and by viral protease inhibitors: relation to drug interactions in vivo. J Pharm Sci. 1998 Oct;87(10):1184-9.
11 Differential inhibition of cytochrome P450 3A4, 3A5 and 3A7 by five human immunodeficiency virus (HIV) protease inhibitors in vitro. Basic Clin Pharmacol Toxicol. 2006 Jan;98(1):79-85.
12 Binding of anti-HIV drugs to human serum albumin. IUBMB Life. 2004 Oct;56(10):609-14. doi: 10.1080/15216540400016286.
13 Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicol Sci. 2010 Dec; 118(2):485-500.
14 The HIV protease inhibitor saquinavir induces endoplasmic reticulum stress, autophagy, and apoptosis in ovarian cancer cells. Gynecol Oncol. 2009 Mar;112(3):623-30. doi: 10.1016/j.ygyno.2008.11.028. Epub 2009 Jan 15.
15 Prediction of aryl hydrocarbon receptor-mediated enzyme induction of drugs and chemicals by mRNA quantification. Chem Res Toxicol. 1998 Dec;11(12):1447-52.
16 Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis. Chem Res Toxicol. 2015 May 18;28(5):927-34. doi: 10.1021/tx5005248. Epub 2015 Apr 3.
17 Population-based in vitro hazard and concentration-response assessment of chemicals: the 1000 genomes high-throughput screening study. Environ Health Perspect. 2015 May;123(5):458-66. doi: 10.1289/ehp.1408775. Epub 2015 Jan 13.
18 Quantification of HIV protease inhibitors and non-nucleoside reverse transcriptase inhibitors in peripheral blood mononuclear cell lysate using liq... J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Feb 15;877(5-6):575-80.
19 Anti-HIV drugs: 25 compounds approved within 25 years after the discovery of HIV. Int J Antimicrob Agents. 2009 Apr;33(4):307-20.
20 Hollow-fiber unit evaluation of a new human immunodeficiency virus type 1 protease inhibitor, BMS-232632, for determination of the linked pharmacod... J Infect Dis. 2001 Apr 1;183(7):1126-9.
21 Darunavir: a review of its use in the management of HIV infection in adults. Drugs. 2009;69(4):477-503.
22 2006 drug approvals: finding the niche. Nat Rev Drug Discov. 2007 Feb;6(2):99-101.
23 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
24 Fosamprenavir/ritonavir in advanced HIV disease (TRIAD): a randomized study of high-dose, dual-boosted or standard dose fosamprenavir/ritonavir in ... J Antimicrob Chemother. 2009 Aug;64(2):398-410.
25 2011 Pipeline of Boehringer Ingelheim Pharma.
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