General Information of Drug (ID: DMLW57T)

Drug Name
Teniposide Drug Info
Synonyms
PTG; Teniposido; Teniposidum; Vehem; Vumon; Demethyl Epipodophyllotoxin Thenylidine Glucoside; VM 26; Teniposido [INN-Spanish]; Teniposidum [INN-Latin]; VM-26; Vee M-26; Veham-Sandoz; Vumon (TN); Teniposide (USAN/INN); Teniposide [USAN:BAN:INN]; VM-26 (TN); Vumon, VM-26, Vehem, NSC 122819, Teniposide; Epipodophyllotoxin, 4'-demethyl-, 9-(4,6-O-2-thenylidene-beta-D-glucopyranoside); 4'-Demethyl-epipodophyllotoxin-beta-D-thenylidene-glucoside; 4'-Demethylepipodophyllotoxin 9-(4,6-O-(R)-2-thenylidene-beta-D-glucopyranoside); 4'-Demethylepipodophyllotoxin 9-(4,6-O-2-thenylidene-beta-D-glucopyranoside); 4'-Demethylepipodophyllotoxin thenylidene glucoside; 4'-Demethylepipodophyllotoxin-beta-D-thenylidine glucoside; 4'-Dimethyl-9-(4,6-O-2-thenyid)-epipodophyllotoxin; 4-Demethylepipodophyllotoxin-.beta.-D-thenylideneglucoside
Indication
Disease Entry ICD 11 Status REF
Acute lymphoblastic leukaemia 2A85 Approved [1]
Therapeutic Class
Anticancer Agents
Cross-matching ID
PubChem CID
452548
CAS Number
CAS 29767-20-2
TTD Drug ID
DMLW57T
VARIDT Drug ID
DR00021
INTEDE Drug ID
DR1550

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Drug(s) Targeting DNA topoisomerase II (TOP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [2]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [12]
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [13]
Idarubicin DMM0XGL Acute myelogenous leukaemia 2A41 Approved [2]
Epirubicin DMPDW6T Solid tumour/cancer 2A00-2F9Z Approved [2]
Lomefloxacin DMVRH9C Bacterial infection 1A00-1C4Z Approved [14]
Dexrazoxane DMD7X1O Breast cancer 2C60-2C65 Approved [2]
Podofilox DMT2EJP Condyloma 1A95 Approved [15]
Enoxacin DMYTE6L Acute gonococcal cervicitis Approved [16]
Amsacrine DMZKYIV Acute lymphoblastic leukaemia 2A85 Approved [17]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [18]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [19]
Methotrexate DM2TEOL Anterior urethra cancer Approved [4]
Folic Acid DMEMBJC Colorectal carcinoma Approved [20]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [4]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [4]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [21]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [4]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [22]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [23]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [24]
Methotrexate DM2TEOL Anterior urethra cancer Approved [25]
Folic Acid DMEMBJC Colorectal carcinoma Approved [26]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [27]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [28]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [29]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [30]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [29]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [31]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [32]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [33]
Folic Acid DMEMBJC Colorectal carcinoma Approved [34]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [35]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [36]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [37]
Glibenclamide DM8JXPZ Diabetic complication 5A2Y Approved [38]
Morphine DMRMS0L Advanced cancer 2A00-2F9Z Approved [39]
Cefadroxil DMMC345 Bacterial infection 1A00-1C4Z Approved [40]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [41]
Efavirenz DMC0GSJ Human immunodeficiency virus infection 1C62 Approved [42]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [43]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [44]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [45]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [46]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [47]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [48]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [49]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [50]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [44]
Verapamil DMA7PEW Angina pectoris BA40 Approved [51]
Eplerenone DMF0NQR Heart failure BD10-BD13 Approved [70]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [71]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [72]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [73]
Proguanil DMBL79I Malaria 1F40-1F45 Approved [74]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [74]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [75]
Nelfinavir mesylate DMFX6G8 N. A. N. A. Approved [76]
Capsaicin DMGMF6V Back pain ME84.Z Approved [77]
Axitinib DMGVH6N Renal cell carcinoma 2C90 Approved [78]
⏷ Show the Full List of 20 Drug(s)
Drug(s) Metabolized By Cytochrome P450 3A5 (CYP3A5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [52]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [53]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [54]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [6]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [55]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [56]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [57]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [58]
Verapamil DMA7PEW Angina pectoris BA40 Approved [59]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [6]
Eplerenone DMF0NQR Heart failure BD10-BD13 Approved [70]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [71]
Nelfinavir mesylate DMFX6G8 N. A. N. A. Approved [76]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [76]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [79]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [80]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [81]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [82]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [83]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [84]
⏷ Show the Full List of 20 Drug(s)
Drug(s) Metabolized By Mephenytoin 4-hydroxylase (CYP2C19)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [60]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [61]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [62]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [63]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [64]
Verapamil DMA7PEW Angina pectoris BA40 Approved [65]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [66]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [67]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [68]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [69]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA topoisomerase 1 (TOP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [85]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [86]
Selenium DM25CGV N. A. N. A. Approved [87]
Methotrexate DM2TEOL Anterior urethra cancer Approved [88]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [89]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [90]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [91]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [92]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [93]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [91]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [94]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [95]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [96]
Gefitinib DM15F0X Colon adenocarcinoma Approved [97]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [98]
Selenium DM25CGV N. A. N. A. Approved [99]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [100]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [101]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [102]
Methotrexate DM2TEOL Anterior urethra cancer Approved [103]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [104]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [8]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [105]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [106]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [83]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [107]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [8]
Bezafibrate DMZDCS0 Hypercholesterolaemia 5C80.0 Approved [108]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [109]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [110]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ornithine decarboxylase (ODC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [111]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [112]
Methotrexate DM2TEOL Anterior urethra cancer Approved [113]
Quercetin DM3NC4M Obesity 5B81 Approved [114]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [115]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [115]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [116]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [117]
Propranolol DM79NTF Angina pectoris BA40 Approved [118]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [119]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [120]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [121]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [122]
Gefitinib DM15F0X Colon adenocarcinoma Approved [123]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [124]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [125]
Etretinate DM2CZFA Keratosis ED56 Approved [126]
Prednisone DM2HG4X Acute asthma CA23 Approved [127]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [128]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [129]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [130]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [131]
Panobinostat DM58WKG Chronic graft versus host disease Approved [132]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [133]
Leflunomide DMR8ONJ Arthritis FA20 Approved [134]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [92]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [135]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [83]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [136]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [137]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [138]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [82]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [139]
Gemfibrozil DMD8Q3J Hyperlipidaemia 5C80 Approved [140]
Ethanol DMDRQZU Chronic pain MG30 Approved [141]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [140]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [142]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [143]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [144]
Pioglitazone DMKJ485 Amyotrophic lateral sclerosis 8B60.0 Approved [145]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [146]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [9]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [147]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [130]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [148]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [149]
Quercetin DM3NC4M Obesity 5B81 Approved [150]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [115]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [151]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [152]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [153]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [105]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [154]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [83]
Gemfibrozil DMD8Q3J Hyperlipidaemia 5C80 Approved [140]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [140]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [143]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [144]
Pioglitazone DMKJ485 Amyotrophic lateral sclerosis 8B60.0 Approved [140]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [8]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [155]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [156]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [122]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [157]
Methotrexate DM2TEOL Anterior urethra cancer Approved [158]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [89]
Quercetin DM3NC4M Obesity 5B81 Approved [150]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [159]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [90]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [160]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [161]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [121]
Diazepam DM08E9O Alcohol withdrawal Approved [162]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [163]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [164]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [165]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [166]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [167]
Isradipine DMA5XGH Hypertension BA00-BA04 Approved [168]
Valdecoxib DMAY7H4 Osteoarthritis FA00-FA05 Approved [169]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
DNA topoisomerase II (TOP2) TT0IHXV TOP2A_HUMAN; TOP2B_HUMAN Modulator [2]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Multidrug resistance-associated protein 3 (ABCC3) DTQ3ZHF MRP3_HUMAN Substrate [3]
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [4]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [4]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [5]
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Substrate [6]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Substrate [7]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Cholesteryl ester transfer protein (CETP) OTAGPPOE CETP_HUMAN Gene/Protein Processing [8]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Gene/Protein Processing [8]
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Biotransformations [7]
Cytochrome P450 3A5 (CYP3A5) OTSXFBXB CP3A5_HUMAN Biotransformations [7]
DNA topoisomerase 1 (TOP1) OT51O0CF TOP1_HUMAN Drug Response [9]
DNA topoisomerase 2-alpha (TOP2A) OT6LPS08 TOP2A_HUMAN Drug Response [9]
Fibroblast growth factor 2 (FGF2) OT7YUJ9F FGF2_HUMAN Drug Response [10]
Glucose-6-phosphate 1-dehydrogenase (G6PD) OT300SMK G6PD_HUMAN Drug Response [9]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Gene/Protein Processing [11]
Nuclear receptor-interacting protein 1 (NRIP1) OTIZOJQV NRIP1_HUMAN Gene/Protein Processing [8]

References

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2 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
3 Characterization of drug transport by the human multidrug resistance protein 3 (ABCC3). J Biol Chem. 2001 Dec 7;276(49):46400-7.
4 Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64.
5 Screening for inhibitory effects of antineoplastic agents on CYP3A4 in human liver microsomes. Int J Clin Pharmacol Ther. 2001 Dec;39(12):517-28.
6 Drug Interactions Flockhart Table
7 O-demethylation of epipodophyllotoxins is catalyzed by human cytochrome P450 3A4. Mol Pharmacol. 1994 Feb;45(2):352-8.
8 Regulation of Hepatic Cholesteryl Ester Transfer Protein Expression and Reverse Cholesterol Transport by Inhibition of DNA Topoisomerase II. J Biol Chem. 2015 Jun 5;290(23):14418-29. doi: 10.1074/jbc.M115.643015. Epub 2015 Apr 25.
9 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
10 Adenovirus-mediated transfer of siRNA against basic fibroblast growth factor mRNA enhances the sensitivity of glioblastoma cells to chemotherapy. Med Oncol. 2011 Mar;28(1):24-30. doi: 10.1007/s12032-010-9445-z. Epub 2010 Feb 24.
11 Suppression of c-myc expression and c-Myc function in response to sustained DNA damage in MCF-7 breast tumor cells. Biochem Pharmacol. 2001 Sep 1;62(5):593-602. doi: 10.1016/s0006-2952(01)00699-2.
12 Etoposide, topoisomerase II and cancer.Curr Med Chem Anticancer Agents.2005 Jul;5(4):363-72.
13 Mitoxantrone, a topoisomerase II inhibitor, induces apoptosis of B-chronic lymphocytic leukaemia cells. Br J Haematol. 1998 Jan;100(1):142-6.
14 Inhibition of human topoisomerase IIalpha by fluoroquinolones and ultraviolet A irradiation. Toxicol Sci. 2002 Sep;69(1):16-22.
15 Antitumor properties of podophyllotoxin and related compounds. Curr Pharm Des. 2000 Dec;6(18):1811-39.
16 Clinical pharmacokinetics of the newer antibacterial 4-quinolones. Clin Pharmacokinet. 1988 Feb;14(2):96-121.
17 Design of two etoposide-amsacrine conjugates: topoisomerase II and tubuline polymerization inhibition and relation to cytotoxicity. Anticancer Drug Des. 2000 Dec;15(6):413-21.
18 Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007.
19 MDR1 (ABCB1) G1199A (Ser400Asn) polymorphism alters transepithelial permeability and sensitivity to anticancer agents. Cancer Chemother Pharmacol. 2009 Jun;64(1):183-8.
20 Folate transporter expression decreases in the human placenta throughout pregnancy and in pre-eclampsia. Pregnancy Hypertens. 2012 Apr;2(2):123-31.
21 Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein. Pharm Res. 2001 Dec;18(12):1660-8.
22 Antiestrogens and steroid hormones: substrates of the human P-glycoprotein. Biochem Pharmacol. 1994 Jul 19;48(2):287-92.
23 Association of genetic polymorphisms in the influx transporter SLCO1B3 and the efflux transporter ABCB1 with imatinib pharmacokinetics in patients with chronic myeloid leukemia. Ther Drug Monit. 2011 Apr;33(2):244-50.
24 Doxorubicin transport by RALBP1 and ABCG2 in lung and breast cancer. Int J Oncol. 2007 Mar;30(3):717-25.
25 Wild-type breast cancer resistance protein (BCRP/ABCG2) is a methotrexate polyglutamate transporter. Cancer Res. 2003 Sep 1;63(17):5538-43.
26 The effect of low pH on breast cancer resistance protein (ABCG2)-mediated transport of methotrexate, 7-hydroxymethotrexate, methotrexate diglutamate, folic acid, mitoxantrone, topotecan, and resveratrol in in vitro drug transport models. Mol Pharmacol. 2007 Jan;71(1):240-9.
27 Role of BCRP as a biomarker for predicting resistance to 5-fluorouracil in breast cancer. Cancer Chemother Pharmacol. 2009 May;63(6):1103-10.
28 Inhibiting the function of ABCB1 and ABCG2 by the EGFR tyrosine kinase inhibitor AG1478. Biochem Pharmacol. 2009 Mar 1;77(5):781-93.
29 Sterol transport by the human breast cancer resistance protein (ABCG2) expressed in Lactococcus lactis. J Biol Chem. 2003 Jun 6;278(23):20645-51.
30 The phytoestrogen genistein enhances multidrug resistance in breast cancer cell lines by translational regulation of ABC transporters. Cancer Lett. 2016 Jun 28;376(1):165-72.
31 Curcumin inhibits the activity of ABCG2/BCRP1, a multidrug resistance-linked ABC drug transporter in mice. Pharm Res. 2009 Feb;26(2):480-7.
32 Imatinib mesylate (STI571) is a substrate for the breast cancer resistance protein (BCRP)/ABCG2 drug pump. Blood. 2004 Nov 1;104(9):2940-2.
33 Multidrug resistance protein (MRP) 1 and MRP3 attenuate cytotoxic and transactivating effects of the cyclopentenone prostaglandin, 15-deoxy-Delta(12,14)prostaglandin J2 in MCF7 breast cancer cells. Biochemistry. 2003 May 13;42(18):5429-37.
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