Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMRKXPT)

Drug Name
Ketoprofen Drug Info
Synonyms
Actron; Alrheumat; Alrheumum; Alrheumun; Aneol; Capisten; Dexal; Epatec; Fastum; Kefenid; Ketoprofene; Ketoprofeno; Ketoprofenum; Ketopron; Ketoprophene; Lertus; Menamin; Meprofen; Orudis; Orugesic; Oruvail; Oscorel; Profenid; Toprec; Toprek; Benzoylhydratropic Acid; Orudis KT; K 1751; RP 19583; RP19583; RU 4733; Arthril (TN); Fastum (TN); Fastum Gel (TN); Iso-K; Keto (TN); Ketoflam (TN); Ketomex (TN); Ketonal (TN); Ketoprofenas (TN); Ketoprofene (TN); Ketoprofene [INN-French]; Ketoprofeno [INN-Spanish]; Ketoprofenum (TN); Ketoprofenum [INN-Latin]; Ketorin (TN); Ketospray (TN); Lasonil (TN); M-Benzoylhydratropic acid; Oki (TN); Orudis (TN); Oruvail (TN); RP-19583; Racemic-Ketoprofen; Zon (TN); Bi-Profnid (TN); RP, 19,583; Ketoprofen (JP15/USP/INN); Ketoprofen [USAN:INN:BAN:JAN]; Orudis, Oruvail, Ketoflam, Orudis KT, Ketoprofen; Acide (benzoyl-3-phenyl)-2-propionique; Acide (benzoyl-3-phenyl)-2-propionique [French]; L'Acide (benzoyl-3-phenyl)-2-propionique; (+-)-m-Benzoylhydratropic acid; 2-(3-Benzoylphenyl)propanoic acid; 2-(3-Benzoylphenyl)propionic acid; 2-(m-Benzoylphenyl)propionic acid; 2-[3-(benzoyl)phenyl]propanoic acid; 2-[3-(phenylcarbonyl)phenyl]propanoic acid; 2-[3-Benzoylphenyl]propionic acid; 3-Benzoylhydratropic acid
Indication
Disease Entry ICD 11 Status REF
Bursitis Approved [1]
Dysmenorrhea GA34.3 Approved [1]
Musculoskeletal pain MG30 Approved [2]
Pain MG30-MG3Z Phase 3 [3]
Migraine 8A80 Phase 2 [4]
Osteoarthritis FA00-FA05 Phase 1 [4]
Therapeutic Class
Analgesics
Cross-matching ID
PubChem CID
3825
ChEBI ID
CHEBI:6128
CAS Number
CAS 22071-15-4
TTD Drug ID
DMRKXPT
VARIDT Drug ID
DR00690
INTEDE Drug ID
DR0907
ACDINA Drug ID
D00343

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Prostaglandin G/H synthase 2 (COX-2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [16]
Naproxen DMZ5RGV Bursitis Approved [17]
Etodolac DM6WJO9 Osteoarthritis FA00-FA05 Approved [18]
Indomethacin DMSC4A7 Bursitis Approved [19]
Celecoxib DM6LOQU Dysmenorrhea GA34.3 Approved [20]
Nabumetone DMAT2XH Osteoarthritis FA00-FA05 Approved [21]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [22]
Flurbiprofen DMGN4BY Osteoarthritis FA00-FA05 Approved [23]
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [24]
Aminosalicylic Acid DMENSL5 Crohn disease DD70 Approved [19]
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Drug(s) Metabolized By UDP-glucuronosyltransferase 1A1 (UGT1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [25]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [26]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [27]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [28]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [29]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [30]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [31]
Metronidazole DMTIVEN Abscess Approved [32]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [33]
Ethanol DMDRQZU Chronic pain MG30 Approved [34]
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Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [35]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [36]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [37]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [38]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [39]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [38]
Verapamil DMA7PEW Angina pectoris BA40 Approved [40]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [41]
Estrone DM5T6US Acne vulgaris ED80 Approved [42]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [43]
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Drug(s) Affected By Tumor necrosis factor (TNF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [44]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [45]
Fructose DM43AN2 Vomiting MD90 Approved [12]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [46]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [47]
Baclofen DM0QV1J Multiple sclerosis 8A40 Approved [48]
Gefitinib DM15F0X Colon adenocarcinoma Approved [49]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [50]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [51]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [52]
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Drug(s) Affected By Glutathione reductase, mitochondrial (GSR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [53]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [54]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [55]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [56]
Quercetin DM3NC4M Obesity 5B81 Approved [57]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [58]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [59]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [60]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [61]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [54]
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Drug(s) Affected By Solute carrier family 22 member 1 (SLC22A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Phenoxybenzamine DM8KSQH Malignant essential hypertension BA00 Approved [62]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [63]
Trospium chloride DM32XZT Discovery agent N.A. Approved [64]
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [65]
Lamivudine DMI347A Chronic HBV infection 1E51.0Z Approved [66]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [15]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [67]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [69]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [15]
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Drug(s) Affected By Solute carrier family 22 member 6 (SLC22A6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [70]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [15]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [15]
Quercetin DM3NC4M Obesity 5B81 Approved [71]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [15]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [15]
Succinic acid DMDWICP Malnutrition 5B50-5B71 Approved [72]
Mefenamic acid DMK7HFI Dysmenorrhea GA34.3 Approved [15]
Probenecid DMMFWOJ Acute gonococcal cervicitis Approved [73]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [15]
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Drug(s) Affected By Organic anion transporter 7 (SLC22A9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [15]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [15]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [75]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [76]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [15]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [15]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [67]
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Drug(s) Affected By Solute carrier family 22 member 11 (SLC22A11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [15]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [15]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [67]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [15]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [15]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [79]
Mefenamic acid DMK7HFI Dysmenorrhea GA34.3 Approved [15]
Probenecid DMMFWOJ Acute gonococcal cervicitis Approved [80]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [15]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [81]
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Drug(s) Affected By Solute carrier family 22 member 7 (SLC22A7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aspirin DM672AH Acute coronary syndrome BA41 Approved [15]
Methotrexate DM2TEOL Anterior urethra cancer Approved [82]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [75]
Paclitaxel DMLB81S Breast carcinoma Approved [83]
Allopurinol DMLPAOB Gout FA25 Approved [83]
Bumetanide DMRV7H0 Congestive heart failure BD10 Approved [83]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [83]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [83]
Tetracycline DMZA017 Acne vulgaris ED80 Approved [83]
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [84]
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Drug(s) Affected By Tumor necrosis factor receptor superfamily member 16 (NGFR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [85]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [86]
Methotrexate DM2TEOL Anterior urethra cancer Approved [82]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [87]
Panobinostat DM58WKG Chronic graft versus host disease Approved [88]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [89]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [89]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [90]
Oxaprozin DM9UB0P Osteoarthritis FA00-FA05 Approved [91]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
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Drug(s) Affected By HLA class II histocompatibility antigen, DQ beta 1 chain (HLA-DQB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aspirin DM672AH Acute coronary syndrome BA41 Approved [92]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [13]
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [13]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [93]
Allopurinol DMLPAOB Gout FA25 Approved [94]
Ticlopidine DMO946V Acute coronary syndrome BA41 Approved [95]
Selenium DM25CGV N. A. N. A. Approved [96]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [13]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [97]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [98]
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Drug(s) Affected By Albumin (ALB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [99]
Sulfamethoxazole DMB08GE Acute otitis media AB00 Approved [12]
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [8]
Diazepam DM08E9O Alcohol withdrawal Approved [100]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [101]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [102]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [103]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [104]
Methotrexate DM2TEOL Anterior urethra cancer Approved [105]
Quercetin DM3NC4M Obesity 5B81 Approved [106]
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Drug(s) Affected By L-selectin (SELL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [14]
Meloxicam DM2AR7L Arthritis FA20 Approved [14]
Methotrexate DM2TEOL Anterior urethra cancer Approved [107]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [108]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [109]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [14]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [110]
Nabumetone DMAT2XH Osteoarthritis FA00-FA05 Approved [14]
Phenylbutazone DMAYL0T Chronic pain MG30 Approved [14]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
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Drug(s) Affected By HLA class II histocompatibility antigen, DP alpha 1 chain (HLA-DPA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [96]
Fluoxetine DM3PD2C Bipolar depression Approved [13]
Cinoxacin DM4EWNS Urinary tract infection GC08 Approved [13]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [98]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [111]
Testosterone DM7HUNW Hot flushes GA30 Approved [112]
Valdecoxib DMAY7H4 Osteoarthritis FA00-FA05 Approved [13]
Testosterone enanthate DMB6871 N. A. N. A. Approved [113]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [114]
Cephalexin DMD5JU8 Acute otitis media AB00 Approved [13]
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Drug(s) Affected By Glutamate--cysteine ligase catalytic subunit (GCLC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [115]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [116]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [117]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [56]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [118]
Quercetin DM3NC4M Obesity 5B81 Approved [119]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [120]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [121]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [122]
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Drug(s) Affected By Glutamate--cysteine ligase regulatory subunit (GCLM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [115]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [123]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [56]
Quercetin DM3NC4M Obesity 5B81 Approved [124]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [98]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [60]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [125]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [126]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [127]
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Drug(s) Affected By Cytochrome P450 4A11 (CYP4A11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [128]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [9]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [9]
Methotrexate DM2TEOL Anterior urethra cancer Approved [107]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [58]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [129]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [129]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [9]
Etodolac DM6WJO9 Osteoarthritis FA00-FA05 Approved [9]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [9]
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Drug(s) Affected By Dehydrogenase/reductase SDR family member 11 (DHRS11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [10]
Quercetin DM3NC4M Obesity 5B81 Approved [10]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [98]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
Flufenamic Acid DMC8VNH Dysmenorrhea GA34.3 Approved [10]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [130]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [131]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [132]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Prostaglandin G/H synthase 2 (COX-2) TTVKILB PGH2_HUMAN Inhibitor [5]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Substrate [6]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DEYGVN4 UD11_HUMAN Substrate [7]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Albumin (ALB) OTVMM513 ALBU_HUMAN Protein Interaction/Cellular Processes [8]
Cytochrome P450 4A11 (CYP4A11) OTPU5J0S CP4AB_HUMAN Gene/Protein Processing [9]
Dehydrogenase/reductase SDR family member 11 (DHRS11) OTU3J0ZL DHR11_HUMAN Gene/Protein Processing [10]
Glutamate--cysteine ligase catalytic subunit (GCLC) OTESDI4D GSH1_HUMAN Gene/Protein Processing [11]
Glutamate--cysteine ligase regulatory subunit (GCLM) OT6CP234 GSH0_HUMAN Gene/Protein Processing [11]
Glutathione reductase, mitochondrial (GSR) OTM2TUYM GSHR_HUMAN Drug Response [12]
HLA class II histocompatibility antigen, DP alpha 1 chain (HLA-DPA1) OT7OG7Y2 DPA1_HUMAN Gene/Protein Processing [13]
HLA class II histocompatibility antigen, DQ beta 1 chain (HLA-DQB1) OTVVI3UI DQB1_HUMAN Gene/Protein Processing [13]
L-selectin (SELL) OT6RAJZR LYAM1_HUMAN Gene/Protein Processing [14]
Organic anion transporter 7 (SLC22A9) OTO4BJCC S22A9_HUMAN Gene/Protein Processing [15]

References

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3 Ketoprofen-induced cyclooxygenase inhibition in renal medulla and platelets of rats treated with caffeine. Pharmacology. 2001;63(4):234-9.
4 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5 Probing the skin permeation of fish oil/EPA and ketoprofen-3. Effects on epidermal COX-2 and LOX. Prostaglandins Leukot Essent Fatty Acids. 2007 Jun;76(6):357-62.
6 Clinical pharmacokinetics of ketoprofen enantiomers in wild type of Cyp 2c8 and Cyp 2c9 patients with rheumatoid arthritis. Eur J Drug Metab Pharmacokinet. 2011 Sep;36(3):167-73.
7 Association between the UGT1A1*28 allele and hyperbilirubinemia in HIV-positive patients receiving atazanavir: a meta-analysis. Biosci Rep. 2019 May 2;39(5). pii: BSR20182105.
8 A protein-coated magnetic beads as a tool for the rapid drug-protein binding study. J Pharm Biomed Anal. 2010 Jul 8;52(3):420-4. doi: 10.1016/j.jpba.2009.06.023. Epub 2009 Jun 18.
9 Effects of acidic non-steroidal anti-inflammatory drugs on human cytochrome P450 4A11 activity: Roles of carboxylic acid and a sulfur atom in potent inhibition by sulindac sulfide. Chem Biol Interact. 2023 Sep 1;382:110644. doi: 10.1016/j.cbi.2023.110644. Epub 2023 Jul 25.
10 Rabbit dehydrogenase/reductase SDR family member 11 (DHRS11): Its identity with acetohexamide reductase with broad substrate specificity and inhibitor sensitivity, different from human DHRS11. Chem Biol Interact. 2019 May 25;305:12-20. doi: 10.1016/j.cbi.2019.03.026. Epub 2019 Mar 26.
11 Redox-sensitive interaction between KIAA0132 and Nrf2 mediates indomethacin-induced expression of gamma-glutamylcysteine synthetase. Free Radic Biol Med. 2002 Apr 1;32(7):650-62. doi: 10.1016/s0891-5849(02)00755-4.
12 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
13 Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis. Chem Res Toxicol. 2015 May 18;28(5):927-34. doi: 10.1021/tx5005248. Epub 2015 Apr 3.
14 Structure-function relationship and role of tumor necrosis factor-alpha-converting enzyme in the down-regulation of L-selectin by non-steroidal anti-inflammatory drugs. J Biol Chem. 2002 Oct 11;277(41):38212-21. doi: 10.1074/jbc.M205142200. Epub 2002 Jul 29.
15 Interactions of human organic anion transporters and human organic cation transporters with nonsteroidal anti-inflammatory drugs. J Pharmacol Exp Ther. 2002 Nov;303(2):534-9.
16 Maternal toxicity of nonsteroidal anti-inflammatory drugs as an important factor affecting prenatal development. Reprod Toxicol. 2009 Sep;28(2):239-44.
17 Comparative inhibitory activity of rofecoxib, meloxicam, diclofenac, ibuprofen, and naproxen on COX-2 versus COX-1 in healthy volunteers. J Clin Pharmacol. 2000 Oct;40(10):1109-20.
18 Membranous nephropathy associated with the relatively selective cyclooxygenase-2 inhibitor, etodolac, in a patient with early rheumatoid arthritis. Intern Med. 2007;46(13):1055-8.
19 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
20 Pfizer. Product Development Pipeline. March 31 2009.
21 Renal effects of nabumetone, a COX-2 antagonist: impairment of function in isolated perfused rat kidneys contrasts with preserved renal function in vivo. Exp Nephrol. 2001;9(6):387-96.
22 Privileged structures: a useful concept for the rational design of new lead drug candidates. Mini Rev Med Chem. 2007 Nov;7(11):1108-19.
23 Flurbiprofen, a cyclooxygenase inhibitor, protects mice from hepatic ischemia/reperfusion injury by inhibiting GSK-3 signaling and mitochondrial permeability transition.Mol Med.2012 Sep 25;18:1128-35.
24 Cox-2 inhibitory effects of naturally occurring and modified fatty acids. J Nat Prod. 2001 Jun;64(6):745-9.
25 Functional significance of UDP-glucuronosyltransferase variants in the metabolism of active tamoxifen metabolites. Cancer Res. 2009 Mar 1;69(5):1892-900.
26 Functional characterization of human and cynomolgus monkey UDP-glucuronosyltransferase 1A1 enzymes. Life Sci. 2010 Aug 14;87(7-8):261-8.
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