Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMTV42K)

• Drug Name: G1 Drug Info
• Synonyms: CHEMBL569766; 1-[(3aS,4R,9bR)-4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-8-yl]ethanone; 1-(4-(6-Bromobenzo[1,3]dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-8-yl)-ethanone; SR-01000506928; AC1NT1SF; GTPL1014; SCHEMBL12700948; cid_5322399; cid_3136849; MolPort-003-004-976; ML051; HMS3650I22; ZINC4172149; BDBM50303803; STK330808; AKOS015969580; HY-107216; CS-0027669; UNM000011063001; UNM000000675701; SR-01000506928-1; SR-01000506928-3; 925419-53-0

Indication

Disease Entry	ICD 11	Status	REF
Lymphoma	2A80-2A86	Phase 1/2	[1]
Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[1]

• Cross-matching ID:
  PubChem CID: 5322399
  ChEBI ID: CHEBI:156296
  CAS Number: CAS 881639-98-1
  TTD Drug ID: DMTV42K

Molecule-Related Drug Atlas

Drug(s) Targeting G-protein coupled estrogen receptor 1 (GPER1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Segesterone acetate; ethinyl estradiol	DMFEGB0	Contraception	QA21	Approved	[7]
G15	DMMEC9D	Discovery agent	N.A.	Investigative	[8]
G36	DMDJCIP	Discovery agent	N.A.	Investigative	[9]

Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[10]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[11]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[12]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[13]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[14]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[15]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[16]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[17]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[18]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[19]

Drug(s) Affected By Aryl hydrocarbon receptor (AHR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[20]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[21]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[22]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[23]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[24]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[28]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[29]

Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[11]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[30]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[31]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[32]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[33]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[34]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[35]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[36]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[37]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[38]

Drug(s) Affected By Protein c-Fos (FOS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[39]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[40]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[41]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[42]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[41]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[43]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[44]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[45]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[46]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[47]

Drug(s) Affected By Gap junction alpha-1 protein (GJA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[48]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[52]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[53]
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[48]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[54]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[55]

Drug(s) Affected By PDZ domain-containing protein GIPC1 (GIPC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[59]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[60]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[61]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[62]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[63]

Drug(s) Affected By Protein phosphatase 1 regulatory subunit 12A (PPP1R12A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[64]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[66]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[67]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[68]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Norepinephrine	DMOUC09	Alopecia	ED70	Approved	[70]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[72]

Drug(s) Affected By Forkhead box protein O3 (FOXO3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[6]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[73]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[76]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[77]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[78]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[79]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]

Drug(s) Affected By Tripartite motif-containing protein 16 (TRIM16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[82]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[83]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[68]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[84]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[85]
Penicillin V	DMKVOYF	Acute otitis media	AB00	Approved	[84]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[31]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[32]

Drug(s) Affected By Serine/threonine-protein kinase PAK 4 (PAK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
PF-3758309	DM36PKZ	Solid tumour/cancer	2A00-2F9Z	Phase 1	[87]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[88]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[89]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[64]
SB-431542	DM0YOXQ	Pulmonary fibrosis	CB03.4	Preclinical	[90]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[64]
taurine	DMVW7N3	Discovery agent	N.A.	Investigative	[91]

Drug(s) Affected By Epidermal growth factor receptor (EGFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BIBW 2992	DMTKD7Q	Non-small-cell lung cancer	2C25.Y	Approved	[92]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[93]
Erlotinib	DMCMBHA	Adrenal gland neoplasm		Approved	[94]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[95]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[96]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[97]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[42]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[98]
Selenium	DM25CGV	N. A.	N. A.	Approved	[99]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[100]

Drug(s) Affected By Vasopressin-neurophysin 2-copeptin (AVP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[101]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[102]
Oxprenolol	DM51OQW	Anxiety		Approved	[103]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[105]
Luvox	DMJKROX	Anxiety disorder	6B00-6B0Z	Approved	[106]
Sodium chloride	DMM3950	Skin burns	ME65.0	Approved	[107]
Levodopa	DMN3E57	Parkinson disease	8A00.0	Approved	[102]
Chlorpropamide	DMPHZQE	Non-insulin dependent diabetes	5A11	Approved	[108]

Drug(s) Affected By Prelamin-A/C (LMNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[109]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[110]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[111]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[112]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[113]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[114]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[115]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]

Drug(s) Affected By Estrogen receptor (ESR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[116]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[117]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[118]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[119]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[95]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[120]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[121]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[122]
Procaine	DM4LSNE	Anaesthesia	9A78.6	Approved	[119]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[123]

Drug(s) Affected By 72 kDa type IV collagenase (MMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Selenium	DM25CGV	N. A.	N. A.	Approved	[99]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[125]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[126]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[127]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[128]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[129]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[130]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[131]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[132]

Drug(s) Affected By Microtubule-associated protein tau (MAPT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[133]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[134]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[135]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[136]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[137]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[138]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[68]

Drug(s) Affected By Steroid hormone receptor ERR1 (ESRRA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[139]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[140]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[141]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[142]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[143]
Bortezomib	DMNO38U	Leukemia		Approved	[144]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[145]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[146]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[146]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[147]

Drug(s) Affected By Proto-oncogene tyrosine-protein kinase Src (SRC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bosutinib	DMTI8YE	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[148]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[149]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[140]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[150]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[39]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[151]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[152]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[153]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[153]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]

Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[154]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[20]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[155]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[156]
Selenium	DM25CGV	N. A.	N. A.	Approved	[99]
Pentosan Polysulfate	DM2HRKE	Interstitial cystitis	GC00.3	Approved	[157]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[158]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[159]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[160]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[161]

Drug(s) Affected By Stathmin (STMN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[42]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[162]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[163]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[164]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[165]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[166]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[167]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[168]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[168]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[80]

Drug(s) Affected By Nucleolin (NCL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[40]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[162]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[169]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[170]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[171]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[59]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[172]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[173]

Drug(s) Affected By DNA cytosine-5)-methyltransferase 1 (DNMT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[174]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[175]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[176]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[165]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[178]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[179]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[180]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[181]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[182]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[183]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[184]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[185]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[186]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[187]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[188]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[189]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[190]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[191]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[192]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[193]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[184]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[194]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[195]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[196]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[183]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[197]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[198]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[186]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[187]

Drug(s) Affected By Phosphatidylethanolamine-binding protein 1 (PEBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[199]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[200]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[201]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[201]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[202]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[203]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[204]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[205]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[206]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[207]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[208]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[209]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[210]
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[211]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[212]

Drug(s) Affected By Lamina-associated polypeptide 2, isoform alpha (TMPO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[162]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[30]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[64]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[213]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[214]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[168]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[168]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]

Drug(s) Affected By Serine/threonine-protein kinase mTOR (MTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[215]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[216]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[217]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[218]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[219]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[212]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[220]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[221]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[222]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[223]

Drug(s) Affected By Paxillin (PXN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[140]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[64]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[224]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[225]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[113]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[226]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[227]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[228]
Terbinafine	DMI6HUW	Fungal infection	1F29-1F2F	Approved	[229]

Drug(s) Affected By Choline-phosphate cytidylyltransferase A (PCYT1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[64]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[230]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Bortezomib	DMNO38U	Leukemia		Approved	[144]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[231]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[232]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[147]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[233]

Drug(s) Affected By DNA replication licensing factor MCM2 (MCM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[234]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[235]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[165]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[236]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[237]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[168]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[168]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[238]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]

Drug(s) Affected By Eukaryotic translation initiation factor 5 (EIF5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[162]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[169]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[64]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[39]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[58]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[239]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]

Drug(s) Affected By Caspase-7 (CASP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[154]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[42]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[240]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[241]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[242]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[242]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[109]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[243]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[244]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[245]

Drug(s) Affected By Eukaryotic translation initiation factor 3 subunit B (EIF3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[111]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[246]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[58]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[246]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[230]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[115]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[59]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[247]

Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein K (HNRNPK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[64]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[248]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[249]
Haloperidol	DM96SE0	Delirium		Approved	[201]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[250]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[251]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[252]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[249]

Drug(s) Affected By Small ribosomal subunit protein RACK1 (RACK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[216]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[164]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[253]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[253]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[201]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[201]
Nandrolone	DMFWKG1	Osteoporosis	FB83.0	Approved	[254]

Drug(s) Affected By General transcription factor II-I (GTF2I)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[66]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[230]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[144]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[255]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[169]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[256]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[4]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[257]

Drug(s) Affected By Spectrin beta chain, non-erythrocytic 1 (SPTBN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[258]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[259]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[226]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[260]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[261]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[262]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[263]

Drug(s) Affected By Eukaryotic translation initiation factor 4 gamma 1 (EIF4G1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[264]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[265]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[68]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[247]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[266]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[173]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[256]

Drug(s) Affected By Ras GTPase-activating protein-binding protein 1 (G3BP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[98]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[267]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[230]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[115]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[59]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[256]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[4]

Drug(s) Affected By SNW domain-containing protein 1 (SNW1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[226]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[268]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[4]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[232]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[269]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[89]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[64]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[270]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[271]

Drug(s) Affected By Dihydropyrimidinase-related protein 1 (CRMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[272]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[230]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[273]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[4]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[274]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[88]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[89]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[275]

Drug(s) Affected By Dihydropyrimidinase-related protein 2 (DPYSL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[258]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[276]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[129]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[39]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[226]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[250]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[201]

Drug(s) Affected By E2F-associated phosphoprotein (EAPP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[277]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[4]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[232]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[233]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[88]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[64]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[115]

Drug(s) Affected By La-related protein 1 (LARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[64]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[113]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[173]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[256]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[278]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[232]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[233]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[88]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[64]

Drug(s) Affected By EF-hand domain-containing protein D2 (EFHD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[275]
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[230]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[279]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[4]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[232]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[280]

Drug(s) Affected By SRSF protein kinase 1 (SRPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[246]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[246]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[281]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[169]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[231]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[282]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[56]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[64]

Drug(s) Affected By Partitioning defective 6 homolog beta (PARD6B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[283]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[284]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[280]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[285]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[89]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[64]

Drug(s) Affected By Golgi reassembly-stacking protein 2 (GORASP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[230]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[273]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[232]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[88]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[64]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[64]

Drug(s) Affected By Anillin (ANLN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[169]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[286]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[258]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[165]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[168]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[168]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[287]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[230]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[288]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]

Drug(s) Affected By RNA polymerase I-specific transcription initiation factor RRN3 (RRN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[143]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[289]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[4]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[88]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[89]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[64]

Drug(s) Affected By Protein NDRG2 (NDRG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[258]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[68]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[290]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[262]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[291]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
G-protein coupled estrogen receptor 1 (GPER1)	TTDSB34	GPER1_HUMAN	Agonist	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
72 kDa type IV collagenase (MMP2)	OT5NIWA2	MMP2_HUMAN	Gene/Protein Processing	[3]
Anillin (ANLN)	OTXJY54C	ANLN_HUMAN	Post-Translational Modifications	[4]
Aryl hydrocarbon receptor (AHR)	OTFE4EYE	AHR_HUMAN	Gene/Protein Processing	[5]
Caspase-7 (CASP7)	OTAPJ040	CASP7_HUMAN	Gene/Protein Processing	[6]
Choline-phosphate cytidylyltransferase A (PCYT1A)	OTMH0YLN	PCY1A_HUMAN	Post-Translational Modifications	[4]
Cytochrome P450 1A1 (CYP1A1)	OTE4EFH8	CP1A1_HUMAN	Gene/Protein Processing	[5]
Cytochrome P450 1B1 (CYP1B1)	OTYXFLSD	CP1B1_HUMAN	Gene/Protein Processing	[5]
Dihydropyrimidinase-related protein 1 (CRMP1)	OTJDIQ3C	DPYL1_HUMAN	Post-Translational Modifications	[4]
Dihydropyrimidinase-related protein 2 (DPYSL2)	OTWNQ74H	DPYL2_HUMAN	Post-Translational Modifications	[4]
DNA cytosine-5)-methyltransferase 1 (DNMT1)	OTM2DGTK	DNMT1_HUMAN	Post-Translational Modifications	[4]

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