General Information of Drug (ID: DMUIE76)

Drug Name
Acetaminophen Drug Info
Synonyms
acetaminophen; 4-Acetamidophenol; Paracetamol; 103-90-2; Tylenol; N-(4-Hydroxyphenyl)acetamide; APAP; Acetaminofen; Panadol; Datril; p-Hydroxyacetanilide; N-Acetyl-p-aminophenol; p-Acetamidophenol; Algotropyl; Naprinol; Lonarid; 4'-Hydroxyacetanilide; Multin; Acenol; Acamol; Anelix; p-Acetaminophenol; Liquagesic; Acetagesic; Gelocatil; Servigesic; Acetalgin; Abensanil; Pyrinazine; Injectapap; Clixodyne; Valgesic; Tussapap; Finimal; Paracet; Homoolan; Febrolin; Febrilix; Febridol; Dymadon; Anaflon; Apamide; Valadol; Tralgon; Tabalgin; Lestemp; Alvedon; Abenol; Abrol; Abrolet; Acephen; Acertol; Acetaco; Acetamol; Acetavance; Acetofen; Actamin; Actimol; Afebrin; Afebryl; Aferadol; Algesidal; Algina; Algomol; Alpiny; Alpinyl; Amadil; Aminofen; Analter; Anapap; Andox; Anhiba; Antidol; Anuphen; Apacet; Apadon; Apitrelal; Arfen; Arthralgen; Asetam; Asomal; Aspac; Asplin; Atasol; Atralidon; Babikan; Bacetamol; Banesin; Benmyo; Biocetamol; Cadafen; Calapol; Calmanticold; Calonal; Calpol; Capital; Captin; Causalon; Cefalex; Cetadol; Codabrol; Codalgin; Codapane; Codicet; Codisal; Codoliprane; Cofamol; Conacetol; Cosutone; Cuponol; Curadon; Curpol; Custodial; Dafalgan; Darocet; Darvocet; Daygrip; Deminofen; Democyl; Demogripal; Desfebre; Dhamol; Dimindol; Dirox; Disprol; Dolcor; Dolefin; Dolegrippin; Dolgesic; Doliprane; Dolko; Dolofugin; Doloreduct; Dolorfug; Dolorstop; Dolotec; Dolprone; Dorocoff; Dresan; Dristancito; Duaneo; Dularin; Duorol; Duracetamol; Durapan; Dypap; Ecosetol; Elixodyne; Empracet; Enelfa; Eneril; Excipain; Exdol; Fanalgic; Farmadol; Febranine; Febrectal; Febrectol; Febrex; Febricet; Febrin; Febrinol; Fendon; Fensum; Fepanil; Fevor; Finiweh; Fluparmol; Geluprane; Genapap; Genebs; Grippostad; Gynospasmine; Hedex; Ildamol; Inalgex; Infadrops; Janupap; Kataprin; Korum; Labamol; Lekadol; Lemgrip; Lemsip; Liqiprine; Lupocet; Lyteca; Magnidol; Malgis; Malidens; Maxadol; Medocodene; Mexalen; Minafen; Minoset; Miralgin; Momentum; NEBS; Napafen; Nealgyl; NeoCitran; Neodol; Neodolito; Neopap; Neotrend; Neuridon; NilnOcen; Nina; Nobedon; Nodolex; Noral; Ofirmev; Oltyl; Oralgan; Ortensan; Oxycocet; Paceco; Pacemo; Pacemol; Pacet; Pacimol; Paedialgon; Paedol; Painex; Paldesic; Pamol; Panacete; Panadeine; Panadiene; Panaleve; Panamax; Panasorb; Panasorbe; Panets; Panex; Panodil; Panofen; Pantalgin; Paracemol; Paracenol; Paracetamole; Paracetamolo; Paracetanol; Paracetol; Paracin; Paracod; Paracodol; Parador; Paradrops; Parakapton; Parake; Paralen; Paralief; Paralink; Paralyoc; Paramol; Paramolan; Paranox; Parapan; Parasedol; Parasin; Paraspen; Parcetol; Parelan; Parmol; Parogal; Paroma; Pasolind; Pediapirin; Pediatrix; Pedric; Perfalgan; Phendon; Phenipirin; Phogoglandin; Pinex; Piramin; Pirinasol; Plicet; Polmofen; Predimol; Predualito; Prodol; Prompt; Prontina; Puernol; Pulmofen; Pyrigesic; Pyromed; Redutemp; Reliv; Remedol; Rivalgyl; Robigesic; Rounox; RubieMol; Rubophen; Rupemol; Salzone; Sanicet; Sanicopyrine; Scanol; Scentalgyl; Schmerzex; Sedalito; Semolacin; Seskamol; Setakop; Setamol; Setol; Sifenol; Sinaspril; Sinedol; Sinmol; Stanback; Stopain; Sunetheton; Supofen; Suppap; TYL; Tachiprina; Tapanol; Tapar; Tazamol; Temlo; Tempanal; Tempra; Termacet; Termalgin; Termalgine; Termofren; Tiffy; Titralgan; Treuphadol; Tricoton; Tylex; Tylol; Tymol; Upsanol; Utragin; Valorin; Veralgina; Vermidon; Verpol; Vips; Viruflu; Vivimed; Volpan; Zatinol; Zolben; Aceta Elixir; Actifed Plus; Aspirin free anacin; Bayer Select; D oliprane; Dymadon Co; Fortalidon P; Gattaphen T; Gripin Bebe; Helon N; Influbene N; Jin Gang; Lonarid Mono; Lyteca Syrup; Malex N; Panadeine Co; Panale ve; Pasolind N; Spalt N; Supadol mono; Toximer P; Treupel N; Treupel mon; Ty lenol; Tylex CD; Anacin 3; A-Per; Accu-Tap; Ultracet
Indication
Disease Entry ICD 11 Status REF
Pain MG30-MG3Z Approved [1] , [2] , [3]
Therapeutic Class
Analgesics
Cross-matching ID
PubChem CID
1983
ChEBI ID
CHEBI:46195
CAS Number
CAS 103-90-2
TTD Drug ID
DMUIE76
VARIDT Drug ID
DR01006
INTEDE Drug ID
DR0037
ACDINA Drug ID
D00009

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
Drug Status:
Approved Drug(s)
Investigative Drug(s)
Clinical Trial Drug(s)
Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Solid tumour/cancer 2A00-2F9Z Approved [22]
Progesterone DMUY35B Premature labour JB00 Approved [23]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [24]
Estradiol DMUNTE3 Breast cancer 2C60-2C65 Approved [25]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [26]
Etoposide DMNH3PG Solid tumour/cancer 2A00-2F9Z Approved [27]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [28]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [23]
Verapamil DMA7PEW Hypertension BA00-BA04 Approved [29]
Diclofenac DMPIHLS Osteoarthritis FA00-FA05 Approved [30]
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Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Solid tumour/cancer 2A00-2F9Z Approved [31]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [32]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [33]
Estradiol DMUNTE3 Breast cancer 2C60-2C65 Approved [34]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [35]
Etoposide DMNH3PG Solid tumour/cancer 2A00-2F9Z Approved [27]
Oxaliplatin DMQNWRD Colorectal cancer 2B91.Z Approved [36]
Verapamil DMA7PEW Hypertension BA00-BA04 Approved [37]
Diclofenac DMPIHLS Osteoarthritis FA00-FA05 Approved [38]
Sorafenib DMS8IFC Hepatocellular carcinoma 2C12.02 Approved [39]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [40]
Estradiol DMUNTE3 Breast cancer 2C60-2C65 Approved [41]
Etoposide DMNH3PG Solid tumour/cancer 2A00-2F9Z Approved [42]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [43]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [44]
Mycophenolate mofetil DMPQAGE Organ transplant rejection NE84 Approved [45]
Metronidazole DMTIVEN Amoebiasis 1A36 Approved [46]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [47]
Ethanol DMDRQZU Chronic pain MG30 Approved [48]
Atorvastatin DMF28YC Cardiovascular disease BA00-BE2Z Approved [49]
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Drug(s) Metabolized By Cytochrome P450 2A6 (CYP2A6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Solid tumour/cancer 2A00-2F9Z Approved [31]
Progesterone DMUY35B Premature labour JB00 Approved [11]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [50]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [11]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [51]
Metronidazole DMTIVEN Amoebiasis 1A36 Approved [52]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [53]
Nicotine DMWX5CO Nicotine dependence 6C4A.2 Approved [54]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [11]
Lidocaine DML4ZOT Anaesthesia 9A78.6 Approved [11]
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Drug(s) Metabolized By Cytochrome P450 1A1 (CYP1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Premature labour JB00 Approved [55]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [56]
Estradiol DMUNTE3 Breast cancer 2C60-2C65 Approved [57]
Oxaliplatin DMQNWRD Colorectal cancer 2B91.Z Approved [36]
Diclofenac DMPIHLS Osteoarthritis FA00-FA05 Approved [58]
Estrone DM5T6US Menopausal and postmenopausal disorder GA30 Approved [59]
Erythromycin DM4K7GQ Bacterial infection 1A00-1C4Z Approved [60]
Riboflavin DM8YMWE Acne vulgaris ED80 Approved [61]
Mercaptopurine DMTM2IK Acute lymphoblastic leukaemia 2A85 Approved [62]
Nicotine DMWX5CO Nicotine dependence 6C4A.2 Approved [63]
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Drug(s) Metabolized By Sulfotransferase 1A1 (SULT1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Premature labour JB00 Approved [64]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [65]
Estradiol DMUNTE3 Breast cancer 2C60-2C65 Approved [66]
Aspirin DM672AH Myocardial infarction BA41-BA43 Approved [67]
Warfarin DMJYCVW Atrial fibrillation BC81.3 Approved [68]
Cholic acid DM7OKQV Peroxisomal disorder 5C57 Approved [69]
Liothyronine DM6IR3P Hypothyroidism 5A00 Approved [70]
Epinephrine DM3KJBC Allergy 4A80-4A85 Approved [71]
Benzyl alcohol DMBVYDI Head and body lice 1G00.0 Approved [72]
Teicoplanin DMAQ2LK Bacterial infection 1A00-1C4Z Approved [73]
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Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Solid tumour/cancer 2A00-2F9Z Approved [74]
Progesterone DMUY35B Premature labour JB00 Approved [75]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [76]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [29]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [77]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [78]
Dopamine DMPGUCF Parkinson disease 8A00.0 Approved [79]
Nicotine DMWX5CO Nicotine dependence 6C4A.2 Approved [63]
Propranolol DM79NTF Migraine 8A80 Approved [80]
Amitriptyline DMK7F9S Depression 6A70-6A7Z Approved [81]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Solid tumour/cancer 2A00-2F9Z Approved [82]
Progesterone DMUY35B Premature labour JB00 Approved [83]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [84]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [85]
Trabectedin DMG3Y89 Solid tumour/cancer 2A00-2F9Z Approved [86]
Busulfan DMXYJ9C Myeloproliferative syndrome 2A22 Approved [87]
Artemisinin DMOY7W3 Malaria 1F40-1F45 Approved [88]
Ethacrynic acid DM60QMR High blood pressure BA00 Approved [89]
Tacrine DM51FY6 Alzheimer disease 8A20 Approved [90]
Melphalan DMOLNHF Multiple myeloma 2A83 Approved [91]
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Drug(s) Metabolized By Cytochrome P450 3A5 (CYP3A5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Solid tumour/cancer 2A00-2F9Z Approved [92]
Progesterone DMUY35B Premature labour JB00 Approved [93]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [94]
Estradiol DMUNTE3 Breast cancer 2C60-2C65 Approved [95]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [96]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [97]
Etoposide DMNH3PG Solid tumour/cancer 2A00-2F9Z Approved [98]
Verapamil DMA7PEW Hypertension BA00-BA04 Approved [99]
Sorafenib DMS8IFC Hepatocellular carcinoma 2C12.02 Approved [95]
Estrone DM5T6US Menopausal and postmenopausal disorder GA30 Approved [100]
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Drug(s) Metabolized By Cytochrome P450 2E1 (CYP2E1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Folic acid DMEMBJC Folate-deficiency anemia 3A02.Y Approved [101]
Cisplatin DMRHGI9 Solid tumour/cancer 2A00-2F9Z Approved [102]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [50]
Etoposide DMNH3PG Solid tumour/cancer 2A00-2F9Z Approved [103]
Oxaliplatin DMQNWRD Colorectal cancer 2B91.Z Approved [36]
Verapamil DMA7PEW Hypertension BA00-BA04 Approved [11]
Estrone DM5T6US Menopausal and postmenopausal disorder GA30 Approved [104]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [105]
Ethanol DMDRQZU Chronic pain MG30 Approved [106]
Nicotine DMWX5CO Nicotine dependence 6C4A.2 Approved [107]
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Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Premature labour JB00 Approved [108]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [109]
Estradiol DMUNTE3 Breast cancer 2C60-2C65 Approved [110]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [111]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [11]
Verapamil DMA7PEW Hypertension BA00-BA04 Approved [112]
Diclofenac DMPIHLS Osteoarthritis FA00-FA05 Approved [113]
Estrone DM5T6US Menopausal and postmenopausal disorder GA30 Approved [114]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [115]
Pravastatin DM6A0X7 Hypercholesterolaemia 5C80.0 Approved [116]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Diclofenac DMPIHLS Osteoarthritis FA00-FA05 Approved [117]
Sorafenib DMS8IFC Hepatocellular carcinoma 2C12.02 Approved [118]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Mycophenolate mofetil DMPQAGE Organ transplant rejection NE84 Approved [119]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [29]
Ibuprofen DM8VCBE Pain MG30-MG3Z Approved [29]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [120]
Nateglinide DMLK2QH Diabetic complication 5A2Y Approved [29]
Haloperidol DM96SE0 Schizophrenia 6A20 Approved [29]
Naproxen DMZ5RGV Osteoarthritis FA00-FA05 Approved [121]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Ezetimibe DM7A8TW Hypercholesterolaemia 5C80.0 Approved [122]
Lorazepam DM84ZXF Anxiety disorder 6B00-6B0Z Approved [123]
Hydroxybenzo[a]pyrene DMFSKYE Discovery agent N.A. Investigative [124]
Hydroxybenzo(a)pyrene DM9H5EN Discovery agent N.A. Investigative [124]
BRN-1980310 DMOTU4P Discovery agent N.A. Investigative [124]
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Mycophenolate mofetil DMPQAGE Organ transplant rejection NE84 Approved [45]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [126]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [127]
Aspirin DM672AH Myocardial infarction BA41-BA43 Approved [128]
Naproxen DMZ5RGV Osteoarthritis FA00-FA05 Approved [121]
Deferiprone DMS2M7O Thalassemia 3A50 Approved [129]
Androsterone DMITJAK N. A. N. A. Phase 3 [130]
BCP-13498 DM2BO9W Anaesthesia 9A78.6 Phase 2 [131]
LM-94 DMW3QGJ Primary sclerosing cholangitis DB96.2 Phase 1/2 [132]
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Drug(s) Metabolized By Cytochrome P450 102A1 (cyp102)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Diclofenac DMPIHLS Osteoarthritis FA00-FA05 Approved [133]
Propranolol DM79NTF Migraine 8A80 Approved [134]
Dextromethorphan DMUDJZM Cough MD12 Approved [21]
Nifedipine DMSVOZT Angina pectoris BA40 Approved [135]
Chlorzoxazone DMCYVDT Acute pain MG31 Approved [135]
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [21]
Buspirone DMBS632 Anxiety disorder 6B00-6B0Z Approved [21]
Mefenamic acid DMK7HFI Dysmenorrhea GA34.3 Approved [133]
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [133]
GEA-6414 DM8J0MK Parkinson disease 8A00.0 Phase 1/2 [133]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Solid tumour/cancer 2A00-2F9Z Approved [136]
Methotrexate DM2TEOL leukaemia 2A60-2B33 Approved [137]
Folic acid DMEMBJC Folate-deficiency anemia 3A02.Y Approved [138]
Fluorouracil DMUM7HZ Solid tumour/cancer 2A00-2F9Z Approved [139]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [140]
Cisplatin DMRHGI9 Solid tumour/cancer 2A00-2F9Z Approved [141]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [142]
Etoposide DMNH3PG Solid tumour/cancer 2A00-2F9Z Approved [143]
Oxaliplatin DMQNWRD Colorectal cancer 2B91.Z Approved [144]
Ampicillin DMHWE7P Bacterial infection 1A00-1C4Z Approved [145]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Diclofenac DMPIHLS Osteoarthritis FA00-FA05 Approved [146]
Aspirin DM672AH Myocardial infarction BA41-BA43 Approved [147]
Dexibuprofen DMFYBD0 Ankylosing spondylitis FA92.0 Approved [148]
Ketorolac DMI4EL5 Postoperative inflammation 1A00-CA43.1 Approved [149]
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [150]
Oxaprozin DM9UB0P Rheumatoid arthritis FA20 Approved [151]
Aceclofenac DMZDF0B Inflammation 1A00-CA43.1 Approved [152]
Lornoxicam DMYZFXN Migraine 8A80 Approved [153]
Morniflumate DM9UTDE Otitis media AA80-AB0Z Approved [154]
Nepafenac DMYK490 Osteoarthritis FA00-FA05 Approved [155]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Amitriptyline DMK7F9S Depression 6A70-6A7Z Approved [156]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [157]
Desipramine DMT2FDC Attention deficit hyperactivity disorder 6A05.Z Approved [4]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [158]
Bupropion DM5PCS7 Smoking dependence 6C4A.2 Approved [159]
Tapentadol hydrochloride DMXLSH3 Acute pain MG31 Approved [160]
Venlafaxine DMR6QH0 Depression 6A70-6A7Z Approved [159]
Trimipramine DM1SC8M Major depressive disorder 6A70.3 Approved [161]
Duloxetine DM9BI7M Depression 6A70-6A7Z Approved [162]
Levomilnacipran DMV26S8 Fibromyalgia MG30.01 Approved [163]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Amitriptyline DMK7F9S Depression 6A70-6A7Z Approved [156]
Fluoxetine DM3PD2C Depression 6A70-6A7Z Approved [164]
Vortioxetine DM6F1PU Major depressive disorder 6A70.3 Approved [165]
Sertraline DM0FB1J Depression 6A70-6A7Z Approved [166]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [158]
Bupropion DM5PCS7 Smoking dependence 6C4A.2 Approved [159]
Citalopram DM2G9AE Depression 6A70-6A7Z Approved [164]
Nortriptyline DM4KDYJ Depression 6A70-6A7Z Approved [164]
Trazodone DMK1GBJ Depression 6A70-6A7Z Approved [164]
Paroxetine DM5PVQE Depression 6A70-6A7Z Approved [164]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Norepinephrine transporter (NET) TTAWNKZ SC6A2_HUMAN Inhibitor [4]
Prostaglandin G/H synthase (COX) TTK0943 PGH1_HUMAN; PGH2_HUMAN Inhibitor [5] , [6] , [7]
Serotonin transporter (SERT) TT3ROYC SC6A4_HUMAN Inhibitor [4]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Multidrug resistance-associated protein 2 (ABCC2) DTFI42L MRP2_HUMAN Substrate [8]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [9]
Cytochrome P450 2E1 (CYP2E1) Main DME DEVDYN7 CP2E1_HUMAN Substrate [10]
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Substrate [9]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Substrate [11]
Cytochrome P450 1A1 (CYP1A1) DE6OQ3W CP1A1_HUMAN Substrate [12]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DEYGVN4 UD11_HUMAN Substrate [13]
Glutathione S-transferase alpha-1 (GSTA1) DE4ZHS1 GSTA1_HUMAN Substrate [14]
Cytochrome P450 2A6 (CYP2A6) DEJVYAZ CP2A6_HUMAN Substrate [9]
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Substrate [15]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Substrate [16]
UDP-glucuronosyltransferase 1A9 (UGT1A9) DE85D2P UD19_HUMAN Substrate [17]
Sulfotransferase 1A1 (SULT1A1) DEYWLRK ST1A1_HUMAN Substrate [18]
UDP-glucuronosyltransferase 1A6 (UGT1A6) DESD26P UD16_HUMAN Substrate [19]
UDP-glucuronosyltransferase 2B15 (UGT2B15) DENZ6B1 UDB15_HUMAN Substrate [20]
Cytochrome P450 102A1 (cyp102) DE4OGUF CPXB_BACMB Substrate [21]

References

1 The Diversion of Ultram, Ultracet, and generic tramadol HCL. J Addict Dis. 2006;25(2):53-8.
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5239).
3 FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 018337.
4 Augmentation effect of combination therapy of aripiprazole and antidepressants on forced swimming test in mice. Psychopharmacology (Berl). 2009 Sep;206(1):97-107.
5 Mechanism of action of paracetamol. Am J Ther. 2005 Jan-Feb;12(1):46-55.
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