Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMYQGDV)

Drug Name
MANGOSTIN Drug Info
Synonyms
alpha-Mangostin; Mangostin; 6147/11/1; 1,3,6-Trihydroxy-7-methoxy-2,8-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9-one; Mangostine; NSC30552; NSC27593; NSC-30552; UNII-U6RIV93RU1; U6RIV93RU1; CHEMBL323197; CHEBI:67547; GNRIZKKCNOBBMO-UHFFFAOYSA-N; 1,3,6-trihydroxy-7-methoxy-2,8-diprenylxanthone; TNP00140; NSC 27593; NSC 30552; NSC 139154; AK105375; 1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methylbut-2-enyl)xanthen-9-one; 1,3,6-Trihydroxy-7-methoxy-2,8-bis(3-methyl-2-butenyl)-9H-xanthen-9-one; Q-100010
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
5281650
ChEBI ID
CHEBI:67547
CAS Number
CAS 6147-11-1
TTD Drug ID
DMYQGDV

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Patented Agent(s)
Discontinued Drug(s)
Investigative Drug(s)
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Arachidonate 15-lipoxygenase (15-LOX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indolizine derivative 1 DM4GZBI N. A. N. A. Patented [7]
Imidazole derivative 10 DMI7W3K N. A. N. A. Patented [8]
Indole and benzimidazole derivative 1 DMS0169 N. A. N. A. Patented [8]
Triazole derivative 3 DMZR0TH N. A. N. A. Patented [8]
Isothiazolone derivative 1 DMHAJCM N. A. N. A. Patented [8]
PMID26560362-Compound-90 DM9V13U N. A. N. A. Patented [8]
Imidazole derivative 11 DMTJ0DP N. A. N. A. Patented [8]
Tri-substituted benzene derivative 1 DMEQ3RD N. A. N. A. Patented [8]
NSC-661755 DMDJT7U N. A. N. A. Terminated [1]
KAEMPFEROL DMHEMUB Discovery agent N.A. Investigative [9]
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Drug(s) Targeting Influenza Neuraminidase (Influ NA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Oseltamivir DMGO72P Influenza 1E30-1E32 Approved [10]
Zanamivir DMFMBZ4 Influenza 1E30-1E32 Approved [10]
Peramivir DMNXY5K Influenza virus infection 1E30-1E32 Approved [11]
UX-001 DMD2O0L Hereditary inclusion body myositis 4A41.2 Phase 3 [12]
CS-8958 DM4CSDH Influenza virus infection 1E30-1E32 Phase 3 [11]
DAS-181 DM0Y8JP Influenza virus infection 1E30-1E32 Phase 2 [13]
Lactose DMO4GPK Discovery agent N.A. Phase 1 [12]
GS-3435 DMV7JC6 Influenza virus infection 1E30-1E32 Terminated [14]
BCX-140 DMBJERO Influenza virus infection 1E30-1E32 Terminated [15]
Alpha-D-Mannose DMF5DLW Discovery agent N.A. Investigative [12]
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Drug(s) Targeting Arachidonate 12-lipoxygenase (12-LOX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
NSC-661755 DMDJT7U N. A. N. A. Terminated [1]
PUUPEHEDIONE DMF28IU Discovery agent N.A. Investigative [16]
PUUPEHENONE DMF3BCK Discovery agent N.A. Investigative [17]
Isojaspic acid DMHTBDN Discovery agent N.A. Investigative [16]
(+)-(5S,8S,10S)-20-methoxy-9,15-ene-puupehenol DMLDQWT Discovery agent N.A. Investigative [17]
3,4,6-Tribromo-2-(2,4-dibromo-phenoxy)-phenol DMO34LJ Discovery agent N.A. Investigative [18]
NSC-292213 DMNUSKT Discovery agent N.A. Investigative [1]
Jaspic acid DMOF0TB Discovery agent N.A. Investigative [17]
DYSIDENIN DMIZQTX Discovery agent N.A. Investigative [1]
Polybrominated diphenyl ether derivative DMG7K84 Discovery agent N.A. Investigative [18]
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Drug(s) Affected By Apoptosis-inducing factor 1, mitochondrial (AIFM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [19]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [20]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [21]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [22]
Quercetin DM3NC4M Obesity 5B81 Approved [23]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [24]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [25]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [26]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [27]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
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Drug(s) Affected By Estrogen receptor (ESR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [29]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [30]
Gefitinib DM15F0X Colon adenocarcinoma Approved [31]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [32]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [33]
Liraglutide DM3FXPS Non-insulin dependent diabetes 5A11 Approved [34]
Quercetin DM3NC4M Obesity 5B81 Approved [35]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [36]
Procaine DM4LSNE Anaesthesia 9A78.6 Approved [32]
Estrone DM5T6US Acne vulgaris ED80 Approved [37]
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Drug(s) Affected By Trefoil factor 1 (TFF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [38]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [39]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [40]
Quercetin DM3NC4M Obesity 5B81 Approved [41]
Estrone DM5T6US Acne vulgaris ED80 Approved [42]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [43]
Reserpine DM6VM38 Hypertension BA00-BA04 Approved [40]
Testosterone DM7HUNW Hot flushes GA30 Approved [44]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [45]
Exemestane DM9HPW3 Hormonally-responsive breast cancer 2C60-2C65 Approved [46]
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Drug(s) Affected By Cellular tumor antigen p53 (TP53)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [47]
Methotrexate DM2TEOL Anterior urethra cancer Approved [48]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [49]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [50]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [51]
Paclitaxel DMLB81S Breast carcinoma Approved [52]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [53]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [54]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [55]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [56]
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Drug(s) Affected By 72 kDa type IV collagenase (MMP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [57]
Selenium DM25CGV N. A. N. A. Approved [58]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [59]
Quercetin DM3NC4M Obesity 5B81 Approved [60]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [61]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [62]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [24]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [63]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [64]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [65]
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Drug(s) Affected By High mobility group protein B1 (HMGB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [66]
Gefitinib DM15F0X Colon adenocarcinoma Approved [67]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [39]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [69]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [70]
Testosterone DM7HUNW Hot flushes GA30 Approved [71]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [71]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [72]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [73]
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Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [74]
Gefitinib DM15F0X Colon adenocarcinoma Approved [75]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [76]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [21]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [77]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [78]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [77]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [79]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [80]
Methotrexate DM2TEOL Anterior urethra cancer Approved [81]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [82]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [83]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [84]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [85]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [86]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [74]
Verapamil DMA7PEW Angina pectoris BA40 Approved [87]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [88]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [89]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [90]
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Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [91]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [92]
Gefitinib DM15F0X Colon adenocarcinoma Approved [93]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [94]
Selenium DM25CGV N. A. N. A. Approved [58]
Pentosan Polysulfate DM2HRKE Interstitial cystitis GC00.3 Approved [95]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [79]
Methotrexate DM2TEOL Anterior urethra cancer Approved [96]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [97]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [98]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [99]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [100]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [101]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [89]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [102]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [103]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [104]
Gefitinib DM15F0X Colon adenocarcinoma Approved [105]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [106]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [107]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [108]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [100]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [109]
Paclitaxel DMLB81S Breast carcinoma Approved [110]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [111]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [99]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [86]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [112]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [89]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [102]
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Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [113]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [114]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [54]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [90]
Gefitinib DM15F0X Colon adenocarcinoma Approved [115]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [116]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [117]
Selenium DM25CGV N. A. N. A. Approved [118]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [119]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [120]
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Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 2 (MAP2K2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [121]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [122]
Selenium DM25CGV N. A. N. A. Approved [118]
Quercetin DM3NC4M Obesity 5B81 Approved [123]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [124]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [125]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [126]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [127]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [128]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [129]
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Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [130]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [131]
Gefitinib DM15F0X Colon adenocarcinoma Approved [93]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [132]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [133]
Quercetin DM3NC4M Obesity 5B81 Approved [134]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [135]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [136]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [133]
Ethacrynic acid DM60QMR Edema MG29 Approved [137]
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Drug(s) Affected By Mitogen-activated protein kinase 9 (MAPK9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [131]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [138]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [133]
Methotrexate DM2TEOL Anterior urethra cancer Approved [139]
Quercetin DM3NC4M Obesity 5B81 Approved [140]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [141]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [133]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [142]
Sorbitol DMAN0DE Constipation DD91.1 Approved [143]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
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Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [144]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [145]
Quercetin DM3NC4M Obesity 5B81 Approved [146]
Testosterone DM7HUNW Hot flushes GA30 Approved [147]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [129]
Menthol DMG2KW7 Back pain ME84.Z Approved [149]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [150]
Indomethacin DMSC4A7 Bursitis Approved [151]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [152]
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Drug(s) Affected By Caspase-7 (CASP7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [91]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [153]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [154]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [155]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [156]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [156]
Methotrexate DM2TEOL Anterior urethra cancer Approved [144]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [145]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [157]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [158]
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Drug(s) Affected By Caspase-9 (CASP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [159]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [160]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [74]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [88]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [161]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [162]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [21]
Meloxicam DM2AR7L Arthritis FA20 Approved [163]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [164]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [165]
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Drug(s) Affected By BH3-interacting domain death agonist (BID)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [112]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [21]
Selenium DM25CGV N. A. N. A. Approved [166]
Quercetin DM3NC4M Obesity 5B81 Approved [134]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [167]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [168]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [169]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [170]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [171]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
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Drug(s) Affected By Actin, aortic smooth muscle (ACTA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [172]
Quercetin DM3NC4M Obesity 5B81 Approved [173]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [141]
Panobinostat DM58WKG Chronic graft versus host disease Approved [174]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [175]
Pirfenidone DM6VZFQ Idiopathic pulmonary fibrosis CB03.4 Approved [176]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [177]
Testosterone DM7HUNW Hot flushes GA30 Approved [71]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [178]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [71]
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Drug(s) Affected By Cytochrome c (CYCS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [112]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [179]
Gefitinib DM15F0X Colon adenocarcinoma Approved [75]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [161]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [180]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [155]
Methotrexate DM2TEOL Anterior urethra cancer Approved [48]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [181]
Pefloxacin DM49IGF Gonococcal urethritis 1A70.0Y Approved [182]
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Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 1 (MAP2K1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [121]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [183]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [184]
Ethacrynic acid DM60QMR Edema MG29 Approved [137]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [185]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [186]
Testosterone DM7HUNW Hot flushes GA30 Approved [187]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [72]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [129]
Menthol DMG2KW7 Back pain ME84.Z Approved [149]
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Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [82]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [188]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [74]
Verapamil DMA7PEW Angina pectoris BA40 Approved [87]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [189]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [161]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [190]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [138]
Meloxicam DM2AR7L Arthritis FA20 Approved [191]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [78]
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Drug(s) Affected By Histone deacetylase 1 (HDAC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [138]
Methotrexate DM2TEOL Anterior urethra cancer Approved [192]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [193]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [194]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [195]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [196]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [129]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [197]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [198]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-8 (CASP8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [199]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [200]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [201]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [112]
Gefitinib DM15F0X Colon adenocarcinoma Approved [202]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [203]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [21]
Selenium DM25CGV N. A. N. A. Approved [118]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [164]
Methotrexate DM2TEOL Anterior urethra cancer Approved [48]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NAD-dependent protein deacetylase sirtuin-3, mitochondrial (SIRT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [107]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [135]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [204]
Stavudine DM6DEK9 Human immunodeficiency virus infection 1C62 Approved [135]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [205]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [206]
Chloroquine DMSI5CB Malaria 1F40-1F45 Approved [204]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [207]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [208]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [209]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Arachidonate 12-lipoxygenase (12-LOX) TT12ABZ LOX12_HUMAN Inhibitor [1]
Arachidonate 15-lipoxygenase (15-LOX) TTN9T81 LOX15_HUMAN Inhibitor [1]
Influenza Neuraminidase (Influ NA) TT50QJ3 NRAM_I33A0 Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
72 kDa type IV collagenase (MMP2) OT5NIWA2 MMP2_HUMAN Gene/Protein Processing [3]
Actin, aortic smooth muscle (ACTA2) OTEDLG8E ACTA_HUMAN Gene/Protein Processing [4]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [5]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [5]
Apoptosis-inducing factor 1, mitochondrial (AIFM1) OTKPWB7Q AIFM1_HUMAN Protein Interaction/Cellular Processes [5]
BH3-interacting domain death agonist (BID) OTOSHSHU BID_HUMAN Gene/Protein Processing [5]
Caspase-7 (CASP7) OTAPJ040 CASP7_HUMAN Gene/Protein Processing [5]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Gene/Protein Processing [5]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Gene/Protein Processing [6]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Gene/Protein Processing [5]

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111 Modulation of apoptosis in HaCaT keratinocytes via differential regulation of ERK signaling pathway by flavonoids. J Biol Chem. 2005 Sep 9;280(36):31498-507. doi: 10.1074/jbc.M505537200. Epub 2005 Jul 13.
112 Cannabidiol Modulates the Immunophenotype and Inhibits the Activation of the Inflammasome in Human Gingival Mesenchymal Stem Cells. Front Physiol. 2016 Nov 24;7:559. doi: 10.3389/fphys.2016.00559. eCollection 2016.
113 Inhibition of cholesterol metabolism underlies synergy between mTOR pathway inhibition and chloroquine in bladder cancer cells. Oncogene. 2016 Aug 25;35(34):4518-28. doi: 10.1038/onc.2015.511. Epub 2016 Feb 8.
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115 Dihydromyricetin suppresses tumor growth via downregulation of the EGFR/Akt/survivin signaling pathway. J Biochem Mol Toxicol. 2023 Jun;37(6):e23328. doi: 10.1002/jbt.23328. Epub 2023 Feb 19.
116 Oxidative stress induces parallel autophagy and mitochondria dysfunction in human glioma U251 cells. Toxicol Sci. 2009 Aug;110(2):376-88. doi: 10.1093/toxsci/kfp101. Epub 2009 May 18.
117 Effect of toll-like receptor 7 and 9 targeted therapy to prevent the development of hepatocellular carcinoma. Liver Int. 2015 Mar;35(3):1063-76. doi: 10.1111/liv.12626. Epub 2014 Jul 30.
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