Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMGDA3C)

• Drug Name: cycloheximide Drug Info
• Synonyms: naramycin A; NSC 185; FT 3422-2; NM-MCD 80

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 6197
  ChEBI ID: CHEMBL123292
  CAS Number: CAS 66-81-9
  TTD Drug ID: DMGDA3C
  VARIDT Drug ID: DR01367

Molecule-Related Drug Atlas

Drug(s) Transported By P-glycoprotein 1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[10]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[11]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[12]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[13]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[12]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[12]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[14]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[12]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[15]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[16]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[17]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[18]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[19]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[20]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[21]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[22]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[23]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[24]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[25]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[23]

Drug(s) Affected By ATP-binding cassette sub-family C member 3 (ABCC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[26]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[27]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[28]
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[29]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[30]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[5]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[31]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[32]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[33]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[34]

Drug(s) Affected By ATP-binding cassette sub-family C member 5 (ABCC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[35]
Pemetrexed	DMMX2E6	Central nervous system lymphoma	2B33.5	Approved	[36]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[37]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[5]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[38]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[39]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[40]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[41]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]

Drug(s) Affected By Transforming acidic coiled-coil-containing protein 1 (TACC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[5]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[31]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[44]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[47]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[48]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[49]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[50]

Drug(s) Affected By Receptor tyrosine-protein kinase erbB-2 (ERBB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Trastuzumab	DMZQOUX	Breast cancer	2C60-2C65	Approved	[51]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[52]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[53]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[5]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[54]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[55]
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]

Drug(s) Affected By Insulin-like growth factor-binding protein 4 (IGFBP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[5]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[60]
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[61]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[64]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[65]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[66]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[67]

Drug(s) Affected By CCN family member 3 (CCN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[5]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[31]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[68]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[69]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[70]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[71]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[72]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[5]
Lucanthone	DMZLBUO	Solid tumour/cancer	2A00-2F9Z	Approved	[73]

Drug(s) Affected By Dynamin-1-like protein (DNM1L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[74]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[75]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[76]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[77]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[47]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[78]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[79]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[74]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[80]

Drug(s) Affected By Apoptotic protease-activating factor 1 (APAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[81]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[84]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[85]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[86]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[47]

Drug(s) Affected By Glycosylphosphatidylinositol anchor attachment 1 protein (GPAA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[89]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[47]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[48]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[90]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[91]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[92]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[93]

Drug(s) Affected By Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[94]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[95]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[97]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[98]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[100]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[101]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[102]

Drug(s) Affected By Glia-derived nexin (SERPINE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[31]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[103]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[104]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[105]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[89]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[47]

Drug(s) Affected By ETS domain-containing protein Elk-1 (ELK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[52]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[55]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[106]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[107]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[108]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[109]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[110]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[111]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[69]

Drug(s) Affected By CCN family member 2 (CCN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[112]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[113]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[60]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[114]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[116]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[117]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[104]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[118]

Drug(s) Affected By Kappa-type opioid receptor (OPRK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[119]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[120]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[121]
Morphine	DMRMS0L	Advanced cancer	2A00-2F9Z	Approved	[122]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[44]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[123]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[51]

Drug(s) Affected By Collagenase 3 (MMP13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[124]
Clindamycin	DM15HL8	Acne vulgaris	ED80	Approved	[125]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[124]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[126]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[127]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[128]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[129]
Doxycycline	DM7ICNU	Acne vulgaris	ED80	Approved	[125]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[130]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[131]

Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein H2 (HNRNPH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[132]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[47]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[133]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[134]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[135]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[136]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[137]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[138]

Drug(s) Affected By Single-stranded DNA-binding protein, mitochondrial (SSBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[41]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[110]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[140]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[47]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[141]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[142]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[143]

Drug(s) Affected By Mitogen-activated protein kinase 7 (MAPK7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[38]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[89]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[145]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[146]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[134]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[147]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[147]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[135]

Drug(s) Affected By Pappalysin-1 (PAPPA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[103]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[148]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[149]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[150]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[151]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[69]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[152]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[153]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[154]

Drug(s) Affected By SERTA domain-containing protein 2 (SERTAD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[155]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[156]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[48]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[142]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[157]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[158]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[134]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[135]

Drug(s) Affected By Next to BRCA1 gene 1 protein (NBR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[31]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[119]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[111]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[160]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[161]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[48]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[162]

Drug(s) Affected By 5'-3' exonuclease PLD3 (PLD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[163]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[47]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[152]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[141]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[50]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[31]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[164]

Drug(s) Affected By Synaptopodin (SYNPO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[66]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[68]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[121]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[145]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[134]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[165]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[163]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[166]

Drug(s) Affected By Transmembrane protein 263 (TMEM263)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[47]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[69]
Bortezomib	DMNO38U	Leukemia		Approved	[111]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[48]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[145]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[138]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[167]

Drug(s) Affected By Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase (ST8SIA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[168]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[169]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[170]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[138]
EMODIN	DMAEDQG	Coronavirus Disease 2019 (COVID-19)	1D6Y	Terminated	[171]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[88]

Drug(s) Affected By Sororin (CDCA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[172]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[103]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[173]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[173]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[156]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[89]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[174]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[175]

Drug(s) Affected By Retinoic acid receptor responder protein 2 (RARRES2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[89]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[176]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[152]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[48]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[177]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[178]

Drug(s) Affected By Solute carrier family 22 member 4 (SLC22A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levacecarnine hci	DMJBOCR	Cognitive impairment	6D71	Approved	[179]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[103]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[180]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[156]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[89]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[151]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[181]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[182]

Drug(s) Affected By CDC42 small effector protein 2 (CDC42SE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Bortezomib	DMNO38U	Leukemia		Approved	[111]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[48]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[163]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[93]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[183]

Drug(s) Affected By Myotubularin-related protein 7 (MTMR7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[119]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[138]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[184]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[185]

Drug(s) Affected By Small ribosomal subunit protein uS7m (MRPS7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[66]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[47]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[48]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[79]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[135]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[137]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[186]

Drug(s) Affected By Amino acid transporter heavy chain SLC3A2 (SLC3A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[187]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[103]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[180]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[188]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[189]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[188]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[66]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[190]

Drug(s) Affected By Tumor protein p53-inducible protein 11 (TP53I11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[192]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[150]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[121]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[50]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[193]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[164]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[194]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[144]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[195]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[196]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[81]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[197]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[198]
Selenium	DM25CGV	N. A.	N. A.	Approved	[199]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[195]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[200]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[61]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[200]

Drug(s) Affected By Proepiregulin (EREG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[172]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[201]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[31]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[201]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[201]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[103]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[202]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[201]

Drug(s) Affected By CASP8 and FADD-like apoptosis regulator (CFLAR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[203]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[204]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[205]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[206]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[207]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[208]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[209]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[210]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[211]

Drug(s) Affected By Autophagy-related protein 13 (ATG13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[212]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[89]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[50]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[213]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[183]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[184]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[214]

Drug(s) Affected By Protein phosphatase 1 regulatory subunit 15A (PPP1R15A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[118]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[94]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[198]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[215]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[103]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[148]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[104]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[216]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[217]

Drug(s) Affected By Mitochondrial uncoupling protein 4 (SLC25A27)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[105]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[89]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[157]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[218]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[158]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[135]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[93]
4-hydroxy-2-nonenal	DM2LJFZ	Discovery agent	N.A.	Investigative	[219]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[220]

Drug(s) Affected By Protein c-Fos (FOS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[41]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[221]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[222]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[94]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[222]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[5]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[55]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[223]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[224]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[225]

Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[226]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[51]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[227]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[228]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[229]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[230]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[231]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[232]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[233]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[119]

Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[234]
Selenium	DM25CGV	N. A.	N. A.	Approved	[235]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[116]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[236]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[237]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[238]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[239]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[240]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[241]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[242]

Drug(s) Affected By Transcription factor AP-2-alpha (TFAP2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[243]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[244]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[245]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[246]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[44]
Paroxetine	DM5PVQE	Anxiety disorder	6B00-6B0Z	Approved	[243]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[159]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[149]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[190]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[190]

Drug(s) Affected By Beta-2 adrenergic receptor (ADRB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salmeterol	DMIEU69	Allergic asthma	CA23.0	Approved	[247]
Bambuterol	DMKLSHF	Asthma	CA23	Approved	[248]
Terbutaline	DMD4381	Asthma	CA23	Approved	[249]
Salbutamol	DMN9CWF	Acute asthma	CA23	Approved	[250]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[251]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[61]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[252]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[253]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[254]

Drug(s) Affected By Rho-related GTP-binding protein RhoC (RHOC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[255]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[256]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[257]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[217]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[258]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[150]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[47]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[112]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[259]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[260]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[261]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[262]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[263]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[262]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[264]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[265]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[266]

Drug(s) Affected By Intestinal-type alkaline phosphatase (ALPI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[267]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[268]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[268]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[269]
Wortmannin	DM8EVK5	Haematological malignancy	2B33.Y	Terminated	[267]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[183]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[184]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[270]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[271]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[272]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[273]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[274]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[275]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[276]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[277]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[201]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[278]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[279]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[201]

Drug(s) Affected By E3 SUMO-protein ligase EGR2 (EGR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[31]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[280]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[66]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[89]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[281]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[111]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[69]

Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[282]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[113]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[283]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[284]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[230]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[285]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[286]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[119]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[287]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[288]

Drug(s) Affected By C-C motif chemokine 5 (CCL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[289]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[290]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[291]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[119]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[292]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[103]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[293]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[294]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[295]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[296]

Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[297]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[298]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[94]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[299]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[55]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[300]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[301]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[302]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[303]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[208]

Drug(s) Affected By Receptor tyrosine-protein kinase erbB-3 (ERBB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[113]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[304]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[44]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[149]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[89]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[150]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[305]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[306]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[307]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[308]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[309]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[310]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[311]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[312]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[313]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[314]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[315]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[316]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[317]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[318]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[309]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[319]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[320]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[321]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[308]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[51]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[81]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[311]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[312]

Drug(s) Affected By Retinoblastoma-like protein 1 (RBL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[172]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[322]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[61]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[208]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[103]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[323]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[173]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[173]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[150]

Drug(s) Affected By Protein PML (PML)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[324]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[239]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[242]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[239]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[47]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[325]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[326]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[326]

Drug(s) Affected By Pro-adrenomedullin (ADM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[221]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[198]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[119]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[327]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[156]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[68]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[297]

Drug(s) Affected By Receptor-type tyrosine-protein kinase FLT3 (FLT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quizartinib	DM8Y4JS	Acute myeloid leukaemia	2A60	Approved	[328]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[329]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[184]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[330]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[331]
Venetoclax	DM8I94Y	Chronic lymphocytic leukaemia	2A82.0	Approved	[332]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[333]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[334]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[335]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[336]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[221]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[289]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[337]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[338]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[339]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[340]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[341]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[263]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[195]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 2A (CDKN2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[172]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[38]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[341]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[342]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[208]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[343]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[344]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[345]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[346]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[347]

Drug(s) Affected By E3 ubiquitin-protein ligase RNF4 (RNF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[348]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[89]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[178]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[134]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[349]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[137]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[183]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[152]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[350]

Drug(s) Affected By Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[351]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[89]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[325]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[352]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[353]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[354]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[355]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[164]

Drug(s) Affected By Heat shock factor protein 1 (HSF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[356]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[357]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[357]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[358]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[359]
Ceftazidime	DM41GRA	Bacteremia	1A73	Approved	[357]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Chlorpheniramine	DM5URA2	Allergic rhinitis	CA08.0	Approved	[357]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[357]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[357]

Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[81]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[360]
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[324]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[303]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[361]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[362]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[293]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[363]

Drug(s) Affected By Tight junction protein ZO-1 (TJP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[364]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[55]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[66]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[89]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[47]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[365]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[366]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[367]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[368]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[261]
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[369]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[370]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[207]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[208]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[371]

Drug(s) Affected By Protein NDRG1 (NDRG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[284]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[372]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[324]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[373]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[103]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[89]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[174]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[160]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[69]

Drug(s) Affected By Type II iodothyronine deiodinase (DIO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[112]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[374]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[375]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[376]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[116]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[377]
Ergocalciferol	DMHO0AR	Hypoparathyroidism	5A50	Approved	[378]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[151]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[69]

Drug(s) Affected By Transcription termination factor 3, mitochondrial (MTERF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[69]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[48]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[157]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[134]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[90]

Drug(s) Affected By Endothelial PAS domain-containing protein 1 (EPAS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[379]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[119]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[380]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[44]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[381]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[156]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[89]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Ketorolac	DMI4EL5	Postoperative inflammation	1A00-CA43.1	Approved	[381]

Drug(s) Affected By Repressor of RNA polymerase III transcription MAF1 homolog (MAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[48]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[382]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[158]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[135]
MLN4924	DMP36KD	Myelodysplastic syndrome	2A37	Phase 3	[383]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[138]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[93]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[183]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[183]

Drug(s) Affected By D-ribitol-5-phosphate cytidylyltransferase (CRPPA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[384]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[269]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[93]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[184]

Drug(s) Affected By Rab9 effector protein with kelch motifs (RABEPK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[47]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[48]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[382]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[158]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[135]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[385]

Drug(s) Affected By Kremen protein 1 (KREMEN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[44]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[173]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[173]
Haloperidol	DM96SE0	Delirium		Approved	[386]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[387]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[164]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[134]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[44]

Drug(s) Affected By Unconventional myosin-Id (MYO1D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[44]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[173]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[50]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[145]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[177]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[91]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[135]

Drug(s) Affected By Cation channel sperm-associated protein 4 (CATSPER4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[41]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[138]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[184]

Molecular Interaction Atlas of This Drug

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
5'-3' exonuclease PLD3 (PLD3)	OTL07SP2	PLD3_HUMAN	Gene/Protein Processing	[3]
Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase (ST8SIA1)	OTGND2YZ	SIA8A_HUMAN	Gene/Protein Processing	[3]
Amino acid transporter heavy chain SLC3A2 (SLC3A2)	OTBR33M9	4F2_HUMAN	Gene/Protein Processing	[4]
Apoptotic protease-activating factor 1 (APAF1)	OTJWIVY0	APAF_HUMAN	Gene/Protein Processing	[3]
ATP-binding cassette sub-family C member 3 (ABCC3)	OTC3IJV4	MRP3_HUMAN	Gene/Protein Processing	[5]
ATP-binding cassette sub-family C member 5 (ABCC5)	OT34G4US	MRP5_HUMAN	Gene/Protein Processing	[5]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Gene/Protein Processing	[6]
Autophagy-related protein 13 (ATG13)	OTYMHNEJ	ATG13_HUMAN	Gene/Protein Processing	[7]
Bcl-2-like protein 1 (BCL2L1)	OTRC5K9O	B2CL1_HUMAN	Gene/Protein Processing	[8]
Beta-2 adrenergic receptor (ADRB2)	OTSDOX4Q	ADRB2_HUMAN	Gene/Protein Processing	[9]

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