Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMHN7CB)

• Drug Name: Tributylstannanyl Drug Info
• Synonyms: Tributyltin; tributylstannanyl; Tributlytin; Tributylstannic hydride; TRIBUTYL TIN; Tri-n-butylstannane hydride; UNII-4XDX163P3D; Tin, tri-n-butyl-, hydride; HSDB 6362; EINECS 211-704-4; BRN 3587329; 4XDX163P3D; Stannane, tri-n-butyl-, hydride; 20763-88-6; Tri-n-butyltin hydride, 97%; tri-n-butylstannyl radical; tributyl-tin; TBY; TBTH; AC1MHUMB; AC1Q2UP8; ACMC-1B91A; DTXSID0040709; CTK1A6693; MolPort-003-928-307; PIILXFBHQILWPS-UHFFFAOYSA-N; MolPort-035-869-643; EBD10558; ANW-35557; MFCD00009416; ZINC169748512; AKOS015909735

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 3032732
  CAS Number: CAS 688-73-3
  TTD Drug ID: DMHN7CB

Molecule-Related Drug Atlas

Drug(s) Targeting Retinoic acid receptor RXR-alpha (RXRA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[8]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[9]
2-chloro-5-nitro-N-phenylbenzamide	DMUGQIV	Discovery agent	N.A.	Investigative	[1]
AGN-34	DM5ECDM	Discovery agent	N.A.	Investigative	[10]
LG100754	DMEK4FY	Discovery agent	N.A.	Investigative	[11]
(5BETA)-PREGNANE-3,20-DIONE	DMVQ6RN	Discovery agent	N.A.	Investigative	[1]
phytanic acid	DMSZ1RB	Discovery agent	N.A.	Investigative	[12]
CD3254	DM38MU1	Discovery agent	N.A.	Investigative	[13]
UVI3003	DM95UI1	Discovery agent	N.A.	Investigative	[14]
methoprene acid	DM58A0W	Discovery agent	N.A.	Investigative	[15]

Drug(s) Affected By 3-oxo-5-alpha-steroid 4-dehydrogenase 1 (SRD5A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[16]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[17]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[18]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[19]
Dydrogesterone	DMAKIDV	Menstrual disorder	GA20.3	Approved	[20]
Hydroxyflutamide	DMGIZF5	Prostate cancer	2C82.0	Approved	[21]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[22]
Dutasteride	DMQ4TJK	Benign prostatic hyperplasia	GA90	Approved	[23]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[20]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[24]

Drug(s) Affected By 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (SRD5A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[26]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[27]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[28]
Dutasteride	DMQ4TJK	Benign prostatic hyperplasia	GA90	Approved	[23]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[25]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[29]
Methyltestosterone	DMWLFGO	Advanced cancer	2A00-2F9Z	Approved	[28]
Finasteride	DMWV3TZ	Baldness, male pattern		Approved	[28]

Drug(s) Affected By Choriogonadotropin subunit beta 3 (CGB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[31]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[32]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[34]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[35]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[34]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[36]
Bezafibrate	DMZDCS0	Hypercholesterolaemia	5C80.0	Approved	[37]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[38]

Drug(s) Affected By 17-beta-hydroxysteroid dehydrogenase type 1 (HSD17B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Metyrapone	DMI7FVQ	Cushing disease	5A70	Approved	[41]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[4]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[42]
Dutasteride	DMQ4TJK	Benign prostatic hyperplasia	GA90	Approved	[43]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[44]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[42]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[45]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 3 (SLC2A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[46]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[47]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[48]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[49]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[48]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[50]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[48]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[48]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]

Drug(s) Affected By C-C chemokine receptor type 7 (CCR7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[53]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[56]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[57]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[56]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[22]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[58]

Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[59]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[60]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[61]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[62]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[63]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[64]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[65]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[66]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[67]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[68]

Drug(s) Affected By Nicotinamide phosphoribosyltransferase (NAMPT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[69]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[17]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[71]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[72]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[73]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[74]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[75]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[54]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[74]

Drug(s) Affected By C-X-C chemokine receptor type 4 (CXCR4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[76]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[77]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[78]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[79]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[80]
Carfilzomib	DM48K0X	Multiple myeloma	2A83	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[78]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[82]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[83]

Drug(s) Affected By Estrogen receptor (ESR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[84]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[85]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[86]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[87]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[88]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[89]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[90]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Procaine	DM4LSNE	Anaesthesia	9A78.6	Approved	[87]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[92]

Drug(s) Affected By Phospholipid-transporting ATPase ABCA1 (ABCA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[93]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[94]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[95]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[96]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[97]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[98]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[100]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[101]

Drug(s) Affected By ATP-binding cassette sub-family G member 1 (ABCG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[94]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[103]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[104]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[74]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[74]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[105]

Drug(s) Affected By Protein FAM200C (FAM200C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[106]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[108]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[109]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[22]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[105]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[110]

Drug(s) Affected By DNA damage-inducible transcript 4 protein (DDIT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[111]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[112]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[113]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[114]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[115]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[116]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[117]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[118]

Drug(s) Affected By Krueppel-like factor 2 (KLF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[119]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[120]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[121]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[122]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[53]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[123]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[22]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[58]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[36]

Drug(s) Affected By Steroid 21-hydroxylase (CYP21A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[124]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[125]
Mitotane	DMU1GX0	Adrenocortical carcinoma	2D11.Z	Approved	[126]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[127]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[129]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[130]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[131]
Forskolin	DM6ITNG	Solid tumour/cancer	2A00-2F9Z	Investigative	[41]

Drug(s) Affected By Aromatase (CYP19A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[132]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[133]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[134]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[66]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[134]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[119]
FADROZOLE	DM3C5GZ	Breast cancer	2C60-2C65	Approved	[135]
Bifonazole	DM3KN7V	Fungal infection	1F29-1F2F	Approved	[136]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[137]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[134]

Drug(s) Affected By Cytochrome P450 11B1, mitochondrial (CYP11B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[39]
FADROZOLE	DM3C5GZ	Breast cancer	2C60-2C65	Approved	[135]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[139]
Potassium Chloride	DMMTAJC	Hypokalemia	5C77	Approved	[140]
Mitotane	DMU1GX0	Adrenocortical carcinoma	2D11.Z	Approved	[141]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[142]
Dalcetrapib	DMKNCVM	Acute coronary syndrome	BA41	Phase 3	[143]
Anacetrapib	DMP2BFG	Arteriosclerosis	BD40	Phase 3	[143]

Drug(s) Affected By Cytochrome P450 11B2, mitochondrial (CYP11B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[144]
FADROZOLE	DM3C5GZ	Breast cancer	2C60-2C65	Approved	[135]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[145]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Potassium Chloride	DMMTAJC	Hypokalemia	5C77	Approved	[140]
Dutasteride	DMQ4TJK	Benign prostatic hyperplasia	GA90	Approved	[43]
Mitotane	DMU1GX0	Adrenocortical carcinoma	2D11.Z	Approved	[146]
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[145]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[125]
Irbesartan	DMTP1DC	Diabetic kidney disease	GB61.Z	Approved	[147]

Drug(s) Affected By 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (HSD3B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[148]
Topiramate	DM82Z30	Alcohol dependence	6C40.2	Approved	[149]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[149]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[150]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[125]
Metyrapone	DMI7FVQ	Cushing disease	5A70	Approved	[41]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[148]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[151]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[152]
Levetiracetam	DMTGDN8	Epilepsy	8A60-8A68	Approved	[125]

Drug(s) Affected By Steroidogenic acute regulatory protein, mitochondrial (STAR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[153]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[16]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[154]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[155]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[107]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[150]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[125]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[156]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[157]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[158]

Drug(s) Affected By Nardilysin (NRDC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[159]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[160]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[127]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[161]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[2]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[2]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[162]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[163]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[164]

Drug(s) Affected By Rho-associated protein kinase 2 (ROCK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[165]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[166]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[160]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[167]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[22]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[168]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[36]

Drug(s) Affected By Dickkopf-related protein 1 (DKK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[169]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[170]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[171]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[172]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[104]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[108]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[160]

Drug(s) Affected By Claudin-14 (CLDN14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[173]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[174]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[175]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[27]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[22]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[176]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[24]

Drug(s) Affected By BAG family molecular chaperone regulator 3 (BAG3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[76]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[116]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[177]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[160]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[116]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[179]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[180]

Drug(s) Affected By Mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[181]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[182]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[16]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[183]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[184]
Bortezomib	DMNO38U	Leukemia		Approved	[185]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[22]

Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[186]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[142]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[187]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[188]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[189]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[190]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[191]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[192]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[193]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[119]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[194]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[195]
Fructose	DM43AN2	Vomiting	MD90	Approved	[142]
Ketoprofen	DMRKXPT	Bursitis		Approved	[142]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[196]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[197]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[198]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[199]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[200]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[201]

Drug(s) Affected By Interferon gamma (IFNG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[202]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[203]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[204]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[205]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[119]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[206]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[207]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[208]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[209]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[210]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[211]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[212]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[213]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[67]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[214]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[67]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[215]
Selenium	DM25CGV	N. A.	N. A.	Approved	[216]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[217]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[218]

Drug(s) Affected By Angiogenin (ANG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[219]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[220]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[109]
Enalapril	DMNFUZR	Congestive heart failure	BD10	Approved	[221]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[22]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[58]
Valsartan	DMREUQ6	Chronic heart failure	BD1Z	Approved	[222]

Drug(s) Affected By Thy-1 membrane glycoprotein (THY1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[211]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[223]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[156]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[224]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[225]
Bortezomib	DMNO38U	Leukemia		Approved	[185]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[226]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[227]
Ximelegatran	DMU8ANS	Myocardial infarction	BA41-BA43	Approved	[228]

Drug(s) Affected By Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[229]
Selenium	DM25CGV	N. A.	N. A.	Approved	[230]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[231]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[232]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[233]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[234]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[235]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[160]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[236]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[237]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[119]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[238]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[239]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[240]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[241]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[242]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[243]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[244]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[245]

Drug(s) Affected By Integrin beta-2 (ITGB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[182]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[246]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[17]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[154]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[247]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[248]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[27]

Drug(s) Affected By Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[181]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[249]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[250]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[251]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[252]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[253]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[254]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[255]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[256]

Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[78]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[257]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[258]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[259]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[260]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[212]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[201]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[215]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[261]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[78]

Drug(s) Affected By Intercellular adhesion molecule 1 (ICAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[262]
Dicloxacillin	DM8EU0Z	Bacterial infection	1A00-1C4Z	Approved	[262]
Ergonovine	DM0VEC1	Postpartum haemorrhage	JA43	Approved	[142]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[263]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[264]
Mizolastine	DM1FDN8	Allergic rhinitis	CA08.0	Approved	[265]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[266]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[267]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[268]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[269]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[270]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[271]
Fructose	DM43AN2	Vomiting	MD90	Approved	[142]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[272]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[273]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[181]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[274]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[275]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[276]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[277]

Drug(s) Affected By Protein kinase C beta type (PRKCB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[230]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[278]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[279]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[280]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[281]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[282]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[108]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[278]

Drug(s) Affected By Insulin receptor (INSR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[283]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[119]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[220]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[284]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[285]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[286]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[287]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[288]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[168]

Drug(s) Affected By Lipoprotein lipase (LPL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[142]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[66]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[201]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[289]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[290]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[174]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[291]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[234]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[291]

Drug(s) Affected By Beta-2 adrenergic receptor (ADRB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salmeterol	DMIEU69	Allergic asthma	CA23.0	Approved	[292]
Bambuterol	DMKLSHF	Asthma	CA23	Approved	[293]
Terbutaline	DMD4381	Asthma	CA23	Approved	[294]
Salbutamol	DMN9CWF	Acute asthma	CA23	Approved	[295]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[296]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[50]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[297]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[298]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[299]

Drug(s) Affected By Annexin A5 (ANXA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[112]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[300]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[301]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[302]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[160]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[236]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[236]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[258]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[303]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[304]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[305]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[306]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[307]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[306]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[308]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[309]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[310]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[311]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[312]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[313]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[259]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[273]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[212]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[67]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[214]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[314]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[67]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[315]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[316]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[317]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[318]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[142]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[258]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[319]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[320]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[197]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[321]

Drug(s) Affected By Endoplasmic reticulum chaperone BiP (HSPA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[322]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[323]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[324]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[233]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[325]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[326]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[327]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[328]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[329]

Drug(s) Affected By Heat shock cognate 71 kDa protein (HSPA8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[322]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[181]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[249]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[173]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[233]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[279]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[330]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[302]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[331]

Drug(s) Affected By E3 SUMO-protein ligase EGR2 (EGR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[77]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[174]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[184]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[185]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[224]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 2 (SLC2A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[46]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[173]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[50]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[332]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[333]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[106]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[334]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]

Drug(s) Affected By Alpha-actinin-1 (ACTN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[230]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[335]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[160]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[336]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[22]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[337]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[338]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[127]

Drug(s) Affected By Proto-oncogene tyrosine-protein kinase Src (SRC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bosutinib	DMTI8YE	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[339]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[340]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[119]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[341]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[154]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[342]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[343]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[344]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[344]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]

Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[260]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[66]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[345]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[201]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[190]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[346]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[269]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[119]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[347]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[348]

Drug(s) Affected By Neural cell adhesion molecule 1 (NCAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[16]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[349]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[350]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[351]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[176]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[24]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[352]
Camptothecin	DM6CHNJ	Solid tumour/cancer	2A00-2F9Z	Phase 3	[353]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[354]

Drug(s) Affected By Integrin alpha-4 (ITGA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[355]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[355]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[356]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[280]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[184]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[357]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[358]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[355]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[359]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[110]

Drug(s) Affected By G2/mitotic-specific cyclin-B1 (CCNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[360]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[361]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[274]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[77]
Selenium	DM25CGV	N. A.	N. A.	Approved	[362]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[363]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[307]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[364]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[365]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[366]

Drug(s) Affected By Fatty acid-binding protein, adipocyte (FABP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[367]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[368]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[253]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[369]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[367]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[370]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[97]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[371]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-2 (ATF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[181]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[275]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[50]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[372]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[373]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[374]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[375]
Bortezomib	DMNO38U	Leukemia		Approved	[185]

Drug(s) Affected By Histone H2AX (H2AX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[81]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[376]
Selenium	DM25CGV	N. A.	N. A.	Approved	[230]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[377]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[378]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[379]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[380]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[381]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[382]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[383]

Drug(s) Affected By Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[182]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[253]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[154]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[111]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[160]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[384]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[385]

Drug(s) Affected By 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (PLCG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[120]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[16]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[386]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[387]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[108]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[388]
Ibrutinib	DMHZCPO	Mantle cell lymphoma	2A85.5	Approved	[389]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[58]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[58]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[390]

Drug(s) Affected By Protein kinase C alpha type (PRKCA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[391]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[392]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[16]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[280]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[234]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[160]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[393]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-6 alpha (ATF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[323]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[170]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[323]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[254]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[256]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[394]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[323]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[395]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[396]

Drug(s) Affected By 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[236]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[173]
Procaine	DM4LSNE	Anaesthesia	9A78.6	Approved	[397]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[398]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[160]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[168]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[399]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[338]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[400]

Drug(s) Affected By Azurocidin (AZU1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[401]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[399]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[400]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[402]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[30]
PF-3758309	DM36PKZ	Solid tumour/cancer	2A00-2F9Z	Phase 1	[403]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[130]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[2]

Drug(s) Affected By Integrin alpha-L (ITGAL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[229]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[119]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[246]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[16]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[404]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[83]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[404]
Bortezomib	DMNO38U	Leukemia		Approved	[185]

Drug(s) Affected By Neurofibromin (NF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[405]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[116]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[280]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[335]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[160]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[116]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[127]

Drug(s) Affected By Nucleoside diphosphate kinase B (NME2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[233]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[73]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[406]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[160]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[407]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[408]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[233]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[409]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[337]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[410]

Drug(s) Affected By Galanin peptides (GAL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[411]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[77]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[411]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[220]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[17]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[72]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[75]
Methazolamide	DM7J2TA	Glaucoma/ocular hypertension	9C61	Approved	[411]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[75]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[124]

Drug(s) Affected By Ferrochelatase, mitochondrial (FECH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[229]
Selenium	DM25CGV	N. A.	N. A.	Approved	[230]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[412]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[74]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[74]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[413]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[108]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[74]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[27]
Benzoic Acid	DMKB9FI	Alopecia areata	ED70.2	Approved	[413]

Drug(s) Affected By NF-kappa-B inhibitor alpha (NFKBIA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fructose	DM43AN2	Vomiting	MD90	Approved	[142]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[414]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[211]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[212]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[415]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[416]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[417]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[418]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[282]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[419]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[420]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[421]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[197]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[422]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[423]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[424]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[425]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[426]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[427]

Drug(s) Affected By 5-hydroxytryptamine receptor 2A (HTR2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[142]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[428]
Paliperidone	DM7NPJS	Psychotic disorder	6A20-6A25	Approved	[429]
Haloperidol	DM96SE0	Delirium		Approved	[429]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[224]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[430]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[431]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[338]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[432]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[433]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[420]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[434]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[435]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[436]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[419]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[142]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[211]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[197]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[422]

Drug(s) Affected By M-phase inducer phosphatase 3 (CDC25C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[360]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[229]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[182]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[69]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[16]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[116]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[437]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[438]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[75]

Drug(s) Affected By Catenin alpha-1 (CTNNA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[229]
Selenium	DM25CGV	N. A.	N. A.	Approved	[230]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[50]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[439]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[440]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[441]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[440]
Haloperidol	DM96SE0	Delirium		Approved	[236]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[159]

Drug(s) Affected By Catenin beta-1 (CTNNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[272]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[229]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[442]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[443]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[444]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[445]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[446]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[447]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[448]

Drug(s) Affected By Histamine H1 receptor (HRH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Desloratadine	DM56YN7	Allergic rhinitis	CA08.0	Approved	[449]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[449]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[142]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[450]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[119]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[451]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[430]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[151]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[111]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[452]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[181]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[453]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[323]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[169]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[325]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[454]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[366]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]

Drug(s) Affected By Sterol regulatory element-binding protein 1 (SREBF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[69]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[142]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[76]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[455]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[456]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[457]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[16]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[101]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma (PPARG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[62]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[458]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[459]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[368]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[460]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[461]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[462]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[463]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[464]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[465]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[450]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[274]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[466]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[467]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[169]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[363]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[468]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[307]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[113]

Drug(s) Affected By Leptin (LEP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[260]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[201]
Ramipril	DM2R68E	Acute heart failure	BD10-BD13	Approved	[469]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[470]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[471]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[260]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[260]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[291]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[31]
Amlodipine	DMBDAZV	Angina pectoris	BA40	Approved	[472]

Drug(s) Affected By Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[211]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[77]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[16]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[154]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[473]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[106]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[474]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[475]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]

Drug(s) Affected By Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PIK3CB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[450]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[165]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[476]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[108]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[22]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[24]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[142]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[30]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[477]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[478]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[479]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[240]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[480]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[481]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[482]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[483]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[484]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[414]

Drug(s) Affected By Tyrosine-protein kinase SYK (SYK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[280]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[154]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[108]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[485]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[36]
Diphenylpyraline	DMW4X37	Allergic rhinitis	CA08.0	Approved	[486]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[487]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[280]

Drug(s) Affected By Transcription factor GATA-4 (GATA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[377]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[488]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[280]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[489]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[123]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[490]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[168]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[338]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[24]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[491]

Drug(s) Affected By Collagenase 3 (MMP13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[492]
Clindamycin	DM15HL8	Acne vulgaris	ED80	Approved	[493]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[492]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[120]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[494]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[495]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[121]
Doxycycline	DM7ICNU	Acne vulgaris	ED80	Approved	[493]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[398]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[496]

Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[497]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[272]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[199]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[415]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[276]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[498]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[255]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[499]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[276]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[500]

Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[230]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[50]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[16]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[501]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[374]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[160]

Drug(s) Affected By Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (PIK3CG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[502]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[476]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[503]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[504]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[505]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[506]
GDC0941	DM1YAK6	Breast cancer	2C60-2C65	Phase 2	[473]
GDC-0980/RG7422	DMF3MV1	Non-hodgkin lymphoma	2B33.5	Phase 2	[507]

Drug(s) Affected By Fatty acid synthase (FASN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[508]
Selenium	DM25CGV	N. A.	N. A.	Approved	[230]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[509]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[323]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[510]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[511]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[96]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[512]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[355]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[513]

Drug(s) Affected By CCAAT/enhancer-binding protein alpha (CEBPA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[514]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[512]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[515]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[516]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[291]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[291]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[517]

Drug(s) Affected By Mitogen-activated protein kinase 12 (MAPK12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[518]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[96]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[519]
Sorbitol	DMAN0DE	Constipation	DD91.1	Approved	[520]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[124]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[521]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[522]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[280]
Amsacrine	DMZKYIV	Acute lymphoblastic leukaemia	2A85	Approved	[521]

Drug(s) Affected By Caspase-6 (CASP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[36]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[211]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[77]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[523]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[282]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[524]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[525]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[526]

Drug(s) Affected By Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[243]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[165]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[527]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[119]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[528]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[529]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[530]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[531]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[73]

Drug(s) Affected By Small ribosomal subunit protein eS6 (RPS6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[532]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[50]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[533]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[534]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[535]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[536]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[537]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[538]
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[539]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]

Drug(s) Affected By 11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[540]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[514]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[75]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[75]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[107]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[541]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[155]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[542]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[543]
Oxymetholone	DMFXUT8	Aplastic anemia	3A70	Approved	[544]

Drug(s) Affected By Myosin light chain 5 (MYL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[545]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[16]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[107]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[546]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[547]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[22]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[130]

Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[211]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[321]
Selenium	DM25CGV	N. A.	N. A.	Approved	[230]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[548]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[549]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[282]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[550]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[551]

Drug(s) Affected By Tyrosine-protein phosphatase non-receptor type 11 (PTPN11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[552]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[553]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[554]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[160]
Bortezomib	DMNO38U	Leukemia		Approved	[185]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[22]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[555]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[77]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[127]

Drug(s) Affected By Forkhead box protein O1 (FOXO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[556]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[557]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[405]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[16]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[280]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[558]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[223]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]

Drug(s) Affected By Oxysterols receptor LXR-alpha (NR1H3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[253]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[517]
Gemfibrozil	DMD8Q3J	Hyperlipidaemia	5C80	Approved	[559]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[560]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[559]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[561]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[562]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[224]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[563]

Drug(s) Affected By Serine-protein kinase ATM (ATM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[564]
Paromomycin	DM1AGXN	Amoebiasis	1A36	Approved	[565]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[566]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[363]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[567]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[116]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[451]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[553]

Drug(s) Affected By Rho-associated protein kinase 1 (ROCK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[568]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[69]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[16]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[356]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[73]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[166]
Pamidronate	DMB4AVP	Bone Paget disease		Approved	[569]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[160]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[570]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 3 (BIRC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[571]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[414]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[165]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[305]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[182]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[105]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[553]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[572]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 2 (BIRC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[571]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[414]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[573]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[574]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[575]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[576]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[577]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[572]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[578]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[579]

Drug(s) Affected By Sequestosome-1 (SQSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[187]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[580]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[581]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[112]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[582]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[365]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[182]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[69]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[583]

Drug(s) Affected By Cyclin-dependent kinase 5 activator 1 (CDK5R1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[322]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[584]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[585]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[585]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[586]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[587]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[588]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[587]

Drug(s) Affected By Serine/threonine-protein kinase D1 (PRKD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[75]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[75]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[36]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[338]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[588]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[24]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[589]

Drug(s) Affected By Mitogen-activated protein kinase 14 (MAPK14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[590]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[518]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[415]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[591]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[592]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[593]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[500]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[594]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[595]

Drug(s) Affected By Transcription factor MafA (MAFA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[36]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[596]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[597]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[596]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[130]
Harmine	DMPA5WD	Discovery agent	N.A.	Patented	[598]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[165]

Drug(s) Affected By Ras association domain-containing protein 5 (RASSF5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[108]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[185]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[36]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[24]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[599]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[600]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[130]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[2]
Methyl Mercury Ion	DM6YEW4	Discovery agent	N.A.	Investigative	[2]

Drug(s) Affected By Lipid transferase CIDEC (CIDEC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[219]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[601]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[602]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[176]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[603]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[51]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[604]

Drug(s) Affected By TSC22 domain family protein 3 (TSC22D3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[605]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[275]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[253]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[111]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[106]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[159]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[184]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[606]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[185]

Drug(s) Affected By Junctional adhesion molecule C (JAM3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[159]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[359]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[555]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[599]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[130]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[2]
Methyl Mercury Ion	DM6YEW4	Discovery agent	N.A.	Investigative	[2]

Drug(s) Affected By Partitioning defective 6 homolog beta (PARD6B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[16]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[280]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[160]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[22]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[202]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[599]
G1	DMTV42K	Lymphoma	2A80-2A86	Phase 1/2	[607]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[2]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[608]

Drug(s) Affected By Histone-lysine N-methyltransferase PRDM16 (PRDM16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[165]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[609]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[388]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[610]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[602]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[22]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[610]

Drug(s) Affected By Sphingosine kinase 1 (SPHK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[119]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[220]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[280]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[104]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[398]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Bortezomib	DMNO38U	Leukemia		Approved	[611]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[22]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[612]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10D (TNFRSF10D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[16]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[177]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[118]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[124]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[159]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[184]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[613]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[179]

Drug(s) Affected By Krueppel-like factor 15 (KLF15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[280]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[614]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[151]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[615]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[176]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[24]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[159]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[599]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[616]

Drug(s) Affected By Junctional adhesion molecule A (F11R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[165]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[77]
Selenium	DM25CGV	N. A.	N. A.	Approved	[230]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[108]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[160]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[617]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[36]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[24]

Drug(s) Affected By Chloride intracellular channel protein 4 (CLIC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[16]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[618]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[111]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[546]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[108]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[160]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[236]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[22]

Drug(s) Affected By DNA fragmentation factor subunit beta (DFFB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[619]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[16]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[116]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[177]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[122]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[75]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[75]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[107]

Drug(s) Affected By ATP synthase subunit a (ATP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[620]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[290]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[621]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[517]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[160]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[622]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[623]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[624]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[24]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Retinoic acid receptor RXR-alpha (RXRA)	TT6PEUO	RXRA_HUMAN	Inhibitor	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1)	OTSBQR6D	PLCG1_HUMAN	Gene/Protein Processing	[2]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (PLCG2)	OTGVC9MY	PLCG2_HUMAN	Gene/Protein Processing	[2]
11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2)	OTHF4H9U	DHI2_HUMAN	Gene/Protein Processing	[3]
17-beta-hydroxysteroid dehydrogenase type 1 (HSD17B1)	OT6EBDHM	DHB1_HUMAN	Gene/Protein Processing	[4]
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (HSD3B2)	OT02MSKN	3BHS2_HUMAN	Gene/Protein Processing	[5]
3-oxo-5-alpha-steroid 4-dehydrogenase 1 (SRD5A1)	OTQRET2B	S5A1_HUMAN	Gene/Protein Processing	[6]
3-oxo-5-alpha-steroid 4-dehydrogenase 2 (SRD5A2)	OTTG0NFD	S5A2_HUMAN	Gene/Protein Processing	[6]
5-hydroxytryptamine receptor 2A (HTR2A)	OTWXJX0M	5HT2A_HUMAN	Gene/Protein Processing	[7]
Alpha-actinin-1 (ACTN1)	OTUCLNXH	ACTN1_HUMAN	Gene/Protein Processing	[2]
Angiogenin (ANG)	OT3ECS6P	ANGI_HUMAN	Gene/Protein Processing	[2]

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