Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMKJ485)

• Drug Name: Pioglitazone Drug Info
• Synonyms: 111025-46-8; Actos; Pioglitazona; Pioglitazonum; Glustin; Zactos; 105355-27-9; Pioglitazonum [INN-Latin]; Pioglitazona [INN-Spanish]; Duetact; Pioglitazone [INN:BAN]; Pioglitazone [BAN:INN]; 5-(4-(2-(5-ethylpyridin-2-yl)ethoxy)benzyl)thiazolidine-2,4-dione; AD-4833; U 72107; CHEBI:8228; Pioglitazone (Actos); HSDB 7322; Actos (TN); 5-{4-[2-(5-ethylpyridin-2-yl)ethoxy]benzyl}-1,3-thiazolidine-2,4-dione; C19H20N2O3S; AD 4833; 5-[4-[2-(5-ETHYL-2-PYRIDYL)ETHOXY]BENZYL]-2,4-THIAZOLIDINEDIONE; U 72107A; Actos; Actost; Glustin (TN); HS-0047; Pioglitazone (INN); U-72107; U72,107A; Zactos (TN); (+-)-5-((4-(2-(5-ethyl-2-pyridinyl)ethoxy)phenyl)methyl)-2,4-thiazolidinedione; (+/-)-5-[[4-[2-(5-Ethyl-2-pyridinyl)-ethoxy]phenyl]methyl]-2,4-thiazolidinedione; (+/-)-5-[p-[2-(ethyl-2-pyridyl)ethoxy]benzyl]-2,4-thiazolidinedione; 2,4-Thiazolidinedione, 5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-(9CI); 5-((4-(2-(5-Ethyl-2-pyridinyl)ethoxy)phenyl)methyl)-2,4-thiazolidinedione; 5-(4-(2-(5-ethyl-2-pyridyl)ethoxy)benzyl)-2,4-thiazolidinedione; 5-[4-[2-(5-Ethyl-2-pyridyl)ethoxy]benzyl]thiazolidine-2,4-dione; 5-[[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-thiazolidinedione; 5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione; 5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]thiazolidine-2,4-dione; 5-[[4-[2-[(5-ethyl-2-pyridyl)]ethoxy]phenyl]methyl]thiazolidine-2,4-dione; Linagliptin + pioglitazone; PCG1

Indication

Disease Entry	ICD 11	Status	REF
Amyotrophic lateral sclerosis	8B60.0	Approved	[1]
Diabetic complication	5A2Y	Approved	[2]
Non-insulin dependent diabetes	5A11	Approved	[1]
Type-2 diabetes	5A11	Phase 3	[3]
Endometriosis	GA10	Investigative	[1]
Obesity	5B81	Investigative	[4]

• Therapeutic Class: Hypoglycemic Agents
• Cross-matching ID:
  PubChem CID: 4829
  ChEBI ID: CHEBI:8228
  CAS Number: CAS 111025-46-8
  TTD Drug ID: DMKJ485
  VARIDT Drug ID: DR00518
  INTEDE Drug ID: DR1295
  ACDINA Drug ID: D00534

Molecule-Related Drug Atlas

Drug(s) Targeting Peroxisome proliferator-activated receptor gamma (PPAR-gamma)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[17]
Lobeglitazone	DMHY3IP	Type-2 diabetes	5A11	Approved	[18]
Rosiglitazone XR	DMT45MU	Type-2 diabetes	5A11	Approved	[19]
Thiazolidinedione	DMC1NBW	Alzheimer disease	8A20	Approved	[5]
Glitazone	DMDN4A1	N. A.	N. A.	Phase 4	[20]
MURAGLITAZAR	DMG3NFZ	N. A.	N. A.	Phase 3	[21]
Rivoglitazone	DMBY31K	Ocular inflammation	9C61.24	Phase 3	[22]
Balaglitazone	DMXBHR6	Type-1 diabetes	5A10	Phase 3	[23]
Ragaglitazar	DMFSHEM	Type-1 diabetes	5A10	Phase 3	[24]
CS-038	DM67P0F	Type-2 diabetes	5A11	Phase 3	[25]

Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[27]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[28]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[29]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[30]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[31]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[32]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[33]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[27]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[9]
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[51]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[52]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[53]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[54]
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[55]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[56]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[57]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[58]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[59]

Drug(s) Metabolized By Cytochrome P450 2C8 (CYP2C8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[34]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[35]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[35]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[36]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[37]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[38]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[39]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[35]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[40]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[41]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[60]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[61]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[60]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[61]
Sulfinpyrazone	DMEV954	Gout	FA25	Approved	[62]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[60]
Zafirlukast	DMHNQOG	Asthma	CA23	Approved	[60]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[60]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[63]
Dabrafenib	DMX6OE3	Melanoma	2C30	Approved	[64]

Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[42]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[43]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[44]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[36]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[45]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[36]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[46]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[47]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]

Drug(s) Metabolized By Prostaglandin G/H synthase 1 (COX-1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[9]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[9]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[9]
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[9]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[9]
Nateglinide	DMLK2QH	Diabetic complication	5A2Y	Approved	[9]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[9]
Ketobemidone	DMM3L6Z	Pain	MG30-MG3Z	Approved	[9]
Irbesartan	DMTP1DC	Diabetic kidney disease	GB61.Z	Approved	[9]

Drug(s) Affected By Superoxide dismutase (SOD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[65]
Haloperidol	DM96SE0	Delirium		Approved	[66]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[67]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[68]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[70]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[71]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[72]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[73]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]

Drug(s) Affected By Cytochrome b-245 light chain (CYBA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[75]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[76]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[77]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[80]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma (PPARG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[85]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[86]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[87]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[88]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[90]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[91]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[92]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[93]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[94]

Drug(s) Affected By Peroxisome proliferator-activated receptor alpha (PPARA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[95]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[77]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[96]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[93]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[97]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[98]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[99]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[100]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[101]

Drug(s) Affected By 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[102]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[103]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[104]
Digoxin	DMQCTIH	Arrhythmia	BC9Z	Approved	[66]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[105]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[106]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[76]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[107]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[108]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[11]

Drug(s) Affected By Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[109]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[110]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[111]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[112]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[112]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[112]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[108]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[114]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]

Drug(s) Affected By Cytochrome P450 2B6 (CYP2B6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[115]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[116]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[117]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[118]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[119]
Clopidogrel	DMOL54H	Acute coronary syndrome	BA41	Approved	[120]
Artemisinin	DMOY7W3	Malaria	1F40-1F45	Approved	[121]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[122]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[123]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[124]

Drug(s) Affected By Phospholipid-transporting ATPase ABCA1 (ABCA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[125]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[126]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[76]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[107]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[108]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[127]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[130]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[131]

Drug(s) Affected By Platelet glycoprotein 4 (CD36)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[132]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[133]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[135]
Tolcapone	DM8MNVO	Parkinson disease	8A00.0	Approved	[136]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[137]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Asasantin	DMCZIHT	Cerebrovascular ischaemia	8B1Z	Approved	[140]

Drug(s) Affected By Liver carboxylesterase 1 (CES1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[141]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[142]
Dextropropoxyphene	DM23HCX	Pain	MG30-MG3Z	Approved	[143]
Selenium	DM25CGV	N. A.	N. A.	Approved	[144]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[145]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[146]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[147]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[148]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[149]

Drug(s) Affected By Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[76]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[150]
Haloperidol	DM96SE0	Delirium		Approved	[109]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[101]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[151]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[152]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[13]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]

Drug(s) Affected By Oxysterols receptor LXR-alpha (NR1H3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[155]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[101]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Gemfibrozil	DMD8Q3J	Hyperlipidaemia	5C80	Approved	[156]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[157]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[156]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[158]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[159]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]
Teniposide	DMLW57T	Acute lymphoblastic leukaemia	2A85	Approved	[160]

Drug(s) Affected By Perilipin-2 (PLIN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[161]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[114]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[155]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[162]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[163]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[164]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[165]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[151]

Drug(s) Affected By Steroid 17-alpha-hydroxylase/17,20 lyase (CYP17A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[167]
FADROZOLE	DM3C5GZ	Breast cancer	2C60-2C65	Approved	[168]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[169]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[170]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[171]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[171]
Pyruvic acid	DM7Q41G	Malnutrition	5B50-5B71	Approved	[172]
Topiramate	DM82Z30	Alcohol dependence	6C40.2	Approved	[173]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[173]
ABIRATERONE	DM8V75C	Prostate cancer	2C82.0	Approved	[174]

Drug(s) Affected By 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (HSD3B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[169]
Topiramate	DM82Z30	Alcohol dependence	6C40.2	Approved	[173]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[173]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[175]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[176]
Metyrapone	DMI7FVQ	Cushing disease	5A70	Approved	[177]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[169]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[178]
Levetiracetam	DMTGDN8	Epilepsy	8A60-8A68	Approved	[176]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[179]

Drug(s) Affected By Bile salt export pump (ABCB11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[180]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[181]
Glipizide	DMZA5PQ	Diabetic complication	5A2Y	Approved	[181]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[159]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[180]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[181]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[182]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[180]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[183]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[180]

Drug(s) Affected By Choriogonadotropin subunit beta variant 1 (CGB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[178]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[184]
Forskolin	DM6ITNG	Solid tumour/cancer	2A00-2F9Z	Investigative	[185]

Drug(s) Affected By Immunoglobulin mu Fc receptor (FCMR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[186]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[187]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[188]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[189]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[190]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[191]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[192]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[193]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[194]

Drug(s) Affected By Protein FAM13A (FAM13A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[110]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[76]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[195]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[148]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[101]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[196]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[197]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[198]
Vandetanib	DMRICNP	Solid tumour/cancer	2A00-2F9Z	Approved	[199]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[200]

Drug(s) Affected By Somatotropin (GH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[201]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[202]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[203]
Cyproheptadine	DM92AH3	Allergic rhinitis	CA08.0	Approved	[204]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Sodium oxybate	DMBOV5P	Narcolepsy	7A20	Approved	[205]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[201]
Connexyn	DMF29Q5	Attention deficit hyperactivity disorder	6A05.Z	Approved	[206]
Gamma Hydroxybutyric Acid	DMGBKVD	Narcolepsy	7A20	Approved	[207]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[208]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[209]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[210]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[211]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[212]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[212]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[213]
Selenium	DM25CGV	N. A.	N. A.	Approved	[214]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[215]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[216]

Drug(s) Affected By Keratin, type II cytoskeletal 6A (KRT6A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[217]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[218]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[218]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[220]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[221]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[218]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[222]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[223]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[224]

Drug(s) Affected By Protein S100-A8 (S100A8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[225]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[226]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[225]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[218]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[218]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[227]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[187]
Halothane	DM80OZ5	Anaesthesia	9A78.6	Approved	[225]
Dicloxacillin	DM8EU0Z	Bacterial infection	1A00-1C4Z	Approved	[225]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[228]

Drug(s) Affected By Corticoliberin (CRH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[229]
Meglitinides	DM1OFHN	Type-2 diabetes	5A11	Approved	[230]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[230]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[230]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[231]
Haloperidol	DM96SE0	Delirium		Approved	[230]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[196]
Terbutaline	DMD4381	Asthma	CA23	Approved	[232]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[230]
Risperidone	DMN6DXL	Bipolar I disorder		Approved	[230]

Drug(s) Affected By Pleckstrin (PLEK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[151]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[233]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[234]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[235]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[78]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[236]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[237]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[238]
5'-Guanosine-Diphosphate-Monothiophosphate	DMIARG7	Discovery agent	N.A.	Investigative	[236]

Drug(s) Affected By Matrilysin (MMP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[239]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[240]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[241]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[227]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[220]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[101]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[242]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[243]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[244]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[245]

Drug(s) Affected By Choriogonadotropin subunit beta 3 (CGB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[246]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[247]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[248]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[248]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[249]
Bezafibrate	DMZDCS0	Hypercholesterolaemia	5C80.0	Approved	[250]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[251]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[252]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[253]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[254]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[255]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[256]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[257]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[210]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[212]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[258]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[212]

Drug(s) Affected By C-C motif chemokine 3 (CCL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[259]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[95]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[260]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[261]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[262]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[227]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[263]
Betamethasone	DMAHJEF	Acute adrenal insufficiency		Approved	[264]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[264]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[259]

Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[265]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[266]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[267]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[229]
Selenium	DM25CGV	N. A.	N. A.	Approved	[268]
Pentosan Polysulfate	DM2HRKE	Interstitial cystitis	GC00.3	Approved	[269]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[270]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[271]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[272]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[273]

Drug(s) Affected By Mucin-1 (MUC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[274]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[275]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[162]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[276]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[220]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[276]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[277]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[278]
Bortezomib	DMNO38U	Leukemia		Approved	[233]

Drug(s) Affected By C-C motif chemokine 3-like 1 (CCL3L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[214]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[95]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[279]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[189]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[280]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[281]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[282]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[283]
EUGENOL	DM7US1H	Discovery agent	N.A.	Patented	[284]

Drug(s) Affected By Natriuretic peptides B (NPPB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[285]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[286]
Rhucin	DM3ADGP	Erectile dysfunction	HA01.1	Approved	[287]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[288]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[289]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[290]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[291]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[292]

Drug(s) Affected By fMet-Leu-Phe receptor (FPR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[95]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[293]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[294]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[295]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[99]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[220]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[101]
Masoprocol	DMMVNZ0	Prostate cancer	2C82.0	Approved	[296]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[297]

Drug(s) Affected By Glutathione peroxidase 3 (GPX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[298]
Selenium	DM25CGV	N. A.	N. A.	Approved	[144]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[76]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[108]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[162]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[101]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[299]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[300]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[301]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fructose	DM43AN2	Vomiting	MD90	Approved	[302]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[303]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[148]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[228]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[197]
Mirtazapine	DML53ZJ	Depression	6A70-6A7Z	Approved	[304]
Methamphetamine	DMPM4SK	Anxiety		Approved	[305]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[234]

Drug(s) Affected By Fibulin-1 (FBLN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[110]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[111]
Selenium	DM25CGV	N. A.	N. A.	Approved	[144]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[306]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[306]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[162]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[307]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[220]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[196]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[151]

Drug(s) Affected By G-protein coupled receptor 183 (GPR183)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[95]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[308]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[231]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[308]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[309]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[234]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[310]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[191]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[308]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[311]

Drug(s) Affected By AP-1 complex subunit sigma-2 (AP1S2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[312]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[313]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[197]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[189]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[314]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[234]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[315]

Drug(s) Affected By Insulin gene enhancer protein ISL-1 (ISL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[316]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[195]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[101]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[196]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[317]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[318]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[319]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[311]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[184]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[320]

Drug(s) Affected By Transgelin (TAGLN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[321]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[322]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[323]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[321]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[277]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[321]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[76]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[321]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[324]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[323]

Drug(s) Affected By Regulator of G-protein signaling 1 (RGS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[95]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[325]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[220]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[197]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[326]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[284]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[309]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[280]

Drug(s) Affected By Chitotriosidase-1 (CHIT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[227]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[196]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[327]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[235]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[184]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 3 (BIRC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[328]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[329]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[110]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[330]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[239]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[108]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[195]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[331]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[332]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[333]

Drug(s) Affected By Four and a half LIM domains protein 1 (FHL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[334]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[151]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[277]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[233]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[335]
Isoproterenol	DMK7MEY	Atrioventricular block		Approved	[336]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[337]

Drug(s) Affected By Chorionic somatomammotropin hormone-like 1 (CSHL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[184]

Drug(s) Affected By kinase isozyme 4, mitochondrial (PDK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[325]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[338]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[339]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[340]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[164]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[164]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[164]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[101]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[196]

Drug(s) Affected By Fascin (FSCN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[341]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[186]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[342]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[343]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[80]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[344]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[101]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[197]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[151]

Drug(s) Affected By Ankyrin repeat domain-containing protein SOWAHC (SOWAHC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[111]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[165]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[189]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[345]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[346]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[310]

Drug(s) Affected By Mitochondrial amidoxime-reducing component 1 (MTARC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[347]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[76]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[101]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[196]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[348]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[347]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[349]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[350]

Drug(s) Affected By Isthmin-2 (ISM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[76]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[101]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[189]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[101]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[184]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[351]

Drug(s) Affected By Mitochondrial adenyl nucleotide antiporter SLC25A24 (SLC25A24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[111]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[76]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[151]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[109]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[189]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[352]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[249]

Drug(s) Affected By SPOC domain-containing protein 1 (SPOCD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[322]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[76]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[196]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[353]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[354]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[249]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[346]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[310]

Drug(s) Affected By Transmembrane protein 91 (TMEM91)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[220]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[354]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[354]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[310]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[184]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[355]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[356]

Drug(s) Affected By Retrotransposon-derived protein PEG10 (PEG10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[76]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[114]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[241]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[357]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[81]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[165]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[101]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[151]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[292]

Drug(s) Affected By Mast cell-expressed membrane protein 1 (MCEMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[326]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[234]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[184]

Drug(s) Affected By Retinol dehydrogenase 10 (RDH10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[196]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[151]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[358]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[189]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[335]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[249]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[315]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[191]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[359]

Drug(s) Affected By Leukocyte immunoglobulin-like receptor subfamily A member 2 (LILRA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[294]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[81]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[360]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[78]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[192]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[184]

Drug(s) Affected By C-type lectin domain family 1 member A (CLEC1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[361]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[184]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[362]

Drug(s) Affected By Prostamide/prostaglandin F synthase (PRXL2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[363]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[331]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[364]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[101]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[331]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[189]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[191]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[320]

Drug(s) Affected By Uncharacterized protein C1orf54 (C1ORF54)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[144]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[354]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[354]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[193]

Drug(s) Affected By MICOS complex subunit MIC25 (CHCHD6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[365]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[101]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[366]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[359]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[184]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[110]

Drug(s) Affected By Acetyl-CoA acetyltransferase, cytosolic (ACAT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[76]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[195]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[162]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[227]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[101]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[300]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[151]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[367]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[189]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[353]

Drug(s) Affected By Angiopoietin-related protein 4 (ANGPTL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[66]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[76]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[186]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[342]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[164]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[165]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[164]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[164]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[290]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]

Drug(s) Affected By Very long chain fatty acid elongase 4 (ELOVL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[162]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[196]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[282]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[311]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[359]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[368]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[184]

Drug(s) Affected By Membrane-spanning 4-domains subfamily A member 7 (MS4A7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[220]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[197]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[369]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[370]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[237]
EUGENOL	DM7US1H	Discovery agent	N.A.	Patented	[369]
MICROCYSTIN-LR	DMTMLRN	Discovery agent	N.A.	Investigative	[371]

Drug(s) Affected By B-cell lymphoma/leukemia 11A (BCL11A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[110]
Selenium	DM25CGV	N. A.	N. A.	Approved	[144]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[318]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[313]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[317]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[235]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[318]

Drug(s) Affected By Regulator of cell cycle RGCC (RGCC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[111]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[76]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[114]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[372]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[373]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[76]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[352]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[353]

Drug(s) Affected By Transducin-like enhancer protein 6 (TLE6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[249]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[374]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[311]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[184]

Drug(s) Affected By Endogenous retroviral envelope protein HEMO (ERVMER34-1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[372]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[196]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[352]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[249]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[375]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[311]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[376]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[193]

Drug(s) Affected By Nicotinamide riboside kinase 2 (NMRK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[290]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[319]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[377]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[191]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[311]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[318]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[320]

Drug(s) Affected By GTPase IMAP family member 4 (GIMAP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[187]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[315]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[191]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[184]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[238]

Drug(s) Affected By SLAM family member 5 (CD84)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[331]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[331]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[331]
Epanova	DMHEAGL	Hypertriglyceridemia	5C80.1	Approved	[378]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[331]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[200]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[379]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[184]
Rapamycin Immunosuppressant Drug	DM678IB	Discovery agent	N.A.	Investigative	[331]

Drug(s) Affected By Procollagen C-endopeptidase enhancer 2 (PCOLCE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[76]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[195]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[318]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[372]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[313]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[277]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[189]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]

Drug(s) Affected By C-type lectin domain family 4 member A (CLEC4A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[235]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[184]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[320]
EUGENOL	DM7US1H	Discovery agent	N.A.	Patented	[380]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[381]
cinnamaldehyde	DMZDUXG	Discovery agent	N.A.	Investigative	[380]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[382]
Vidarabine	DM0N85H	Hepatosplenic T-cell lymphoma		Approved	[382]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[383]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[384]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[385]
Etidronic acid	DM1XHYJ	Bone Paget disease		Approved	[382]
Tiaprofenic acid	DM23D7J	Osteoarthritis	FA00-FA05	Approved	[382]
Bromperidol	DM24XYQ	Schizophrenia	6A20	Approved	[382]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[386]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[387]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[388]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[389]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[390]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[391]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[392]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[393]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[394]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[395]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[396]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[394]

Drug(s) Affected By Alternative prion protein (PRNP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[397]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[95]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[318]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[228]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[101]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[300]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[398]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[15]
Bortezomib	DMNO38U	Leukemia		Approved	[233]

Drug(s) Affected By Serine/threonine-protein kinase Sgk1 (SGK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[399]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[400]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[401]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[402]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[76]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[195]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[331]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[399]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[403]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[364]

Drug(s) Affected By Unconventional myosin-Ic (MYO1C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[404]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[151]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[315]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[191]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[319]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[405]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[184]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[406]

Drug(s) Affected By Inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[407]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[408]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[409]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[195]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[407]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[410]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ibrutinib	DMHZCPO	Mantle cell lymphoma	2A85.5	Approved	[411]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[412]

Drug(s) Affected By Proepiregulin (EREG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[413]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[212]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[111]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[212]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[212]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[239]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[76]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[186]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[414]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[212]

Drug(s) Affected By Nephrin (NPHS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[415]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[416]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Bezafibrate	DMZDCS0	Hypercholesterolaemia	5C80.0	Approved	[417]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[311]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[376]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[184]
PIRINIXIC ACID	DM82Y75	Pulmonary fibrosis	CB03.4	Preclinical	[417]
Puromycin	DMDKLB5	N. A.	N. A.	Preclinical	[418]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[419]

Drug(s) Affected By Interleukin-1 alpha (IL1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[363]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[212]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[212]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[229]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[212]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[95]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[420]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[212]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[260]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]

Drug(s) Affected By C-reactive protein (CRP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lidocaine	DML4ZOT	Anaesthesia	9A78.6	Approved	[66]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[421]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[422]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[423]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[108]
Acalabrutinib	DM7GCVW	leukaemia	2A60-2B33	Approved	[424]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[425]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[426]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[427]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[81]

Drug(s) Affected By Apolipoprotein B-100 (APOB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[132]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[111]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[132]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[428]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[76]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[108]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[132]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[429]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[132]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[430]

Drug(s) Affected By Insulin-like growth factor I (IGF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dantrolene	DM1D8XY	Hyperthermia	MG26	Approved	[431]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[229]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[106]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[432]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[218]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[218]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[163]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[433]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[364]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[434]

Drug(s) Affected By Amyloid-beta precursor protein (APP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[397]
Selenium	DM25CGV	N. A.	N. A.	Approved	[144]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[95]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[435]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[186]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[436]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[437]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[276]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[163]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[438]

Drug(s) Affected By Plasminogen activator inhibitor 1 (SERPINE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[439]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[322]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[440]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[441]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[442]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[443]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[108]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[444]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[445]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[446]

Drug(s) Affected By Protein kinase C gamma type (PRKCG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[365]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[311]
Bryostatin-1	DM1JOXY	Alzheimer disease	8A20	Phase 2	[447]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[448]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[184]
Rapamycin Immunosuppressant Drug	DM678IB	Discovery agent	N.A.	Investigative	[449]
NSC-1771	DMNXDGQ	Discovery agent	N.A.	Investigative	[450]

Drug(s) Affected By ATP synthase subunit beta, mitochondrial (ATP5F1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[451]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[111]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[452]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[453]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[454]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[101]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[151]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[455]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[454]

Drug(s) Affected By Protein S100-A9 (S100A9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[225]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[95]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[226]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[218]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[218]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[231]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[456]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[187]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[457]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[101]

Drug(s) Affected By Hepatocyte growth factor receptor (MET)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cabozantinib	DMIYDT4	Medullary thyroid gland carcinoma		Approved	[458]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[459]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[212]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[212]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[212]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[306]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[76]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[212]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[460]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[306]

Drug(s) Affected By C-C motif chemokine 5 (CCL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[68]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[461]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[462]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[95]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[463]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[186]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[464]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[263]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[465]

Drug(s) Affected By G2/mitotic-specific cyclin-B1 (CCNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[413]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[466]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[68]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[111]
Selenium	DM25CGV	N. A.	N. A.	Approved	[467]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[468]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[469]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[470]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[471]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[472]

Drug(s) Affected By Fatty acid-binding protein, adipocyte (FABP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[473]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[88]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[155]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[474]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[473]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[101]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[475]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[127]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[476]

Drug(s) Affected By Protein kinase C alpha type (PRKCA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[477]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[478]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[108]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[318]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[295]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[165]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[151]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[479]

Drug(s) Affected By Cyclin-A2 (CCNA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[480]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[466]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[481]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[105]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[482]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[483]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[472]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[226]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[484]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[76]

Drug(s) Affected By Bone morphogenetic protein 6 (BMP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[212]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[212]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[485]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[212]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[212]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[212]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[212]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[465]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[212]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[228]

Drug(s) Affected By Ribosomal protein S6 kinase beta-1 (RPS6KB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[486]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[487]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[488]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[489]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[490]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[491]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[492]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[493]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[494]

Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[495]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[496]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[497]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[498]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[499]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[500]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[501]
Selenium	DM25CGV	N. A.	N. A.	Approved	[144]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[502]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[503]

Drug(s) Affected By G1/S-specific cyclin-E1 (CCNE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[363]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[504]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[482]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[469]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[483]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[76]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[505]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[506]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[507]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[508]

Drug(s) Affected By Cyclin-dependent kinase 2 (CDK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[413]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[466]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[504]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[509]
Selenium	DM25CGV	N. A.	N. A.	Approved	[467]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[469]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[510]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[271]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[511]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[512]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[513]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[514]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[515]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[516]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[517]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[518]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[519]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[520]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[521]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[522]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[523]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[514]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[524]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[525]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[526]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[513]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[66]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[209]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[516]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[517]

Drug(s) Affected By G1/S-specific cyclin-D3 (CCND3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[413]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[499]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[512]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[527]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[528]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[529]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[530]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[163]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[531]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[364]

Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[532]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[533]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[534]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[85]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[535]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[536]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[537]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[266]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[212]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[538]

Drug(s) Affected By Basigin (BSG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[539]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[540]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[76]
Carfilzomib	DM48K0X	Multiple myeloma	2A83	Approved	[539]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[162]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[541]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[539]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[151]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[109]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[542]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[142]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[68]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[543]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[500]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[105]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[468]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[544]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[469]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[402]

Drug(s) Affected By Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[209]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[111]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[76]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[163]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[545]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[228]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[546]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[547]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[548]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[499]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[544]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[549]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[550]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[551]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[552]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[505]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[553]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[554]

Drug(s) Affected By Stromal cell-derived factor 1 (CXCL12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[67]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[399]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[95]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[555]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[162]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[318]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[399]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[556]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[290]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[557]

Drug(s) Affected By Glycogen synthase kinase-3 beta (GSK3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[558]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[559]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[560]
Selenium	DM25CGV	N. A.	N. A.	Approved	[144]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[561]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[562]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[420]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[563]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[564]

Drug(s) Affected By Oxysterols receptor LXR-beta (NR1H2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[565]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[566]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Gemfibrozil	DMD8Q3J	Hyperlipidaemia	5C80	Approved	[156]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[156]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[159]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[160]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[567]

Drug(s) Affected By Beta-secretase 1 (BACE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[558]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[568]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[569]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[150]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[364]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[570]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[101]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[571]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[196]

Drug(s) Affected By Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[572]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[110]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[573]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[95]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[574]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[575]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[195]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[576]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[577]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[81]

Drug(s) Affected By Cell division control protein 42 homolog (CDC42)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[195]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[163]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[531]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[578]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[579]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[196]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[151]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[580]
Bortezomib	DMNO38U	Leukemia		Approved	[233]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[581]

Drug(s) Affected By Small ribosomal subunit protein eS6 (RPS6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[582]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[286]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[583]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[493]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[584]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[585]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[586]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[587]
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[588]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[101]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[365]
Selenium	DM25CGV	N. A.	N. A.	Approved	[144]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[286]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[196]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[151]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[189]
Bortezomib	DMNO38U	Leukemia		Approved	[233]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[249]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[191]

Drug(s) Affected By Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PPP2CA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[568]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[589]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[590]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[591]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[592]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[593]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[594]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[346]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[595]

Drug(s) Affected By Nucleobindin-2 (NUCB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[342]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[596]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[578]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[81]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[99]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[101]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[196]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[151]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[353]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]

Drug(s) Affected By Tumor necrosis factor-inducible gene 6 protein (TNFAIP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[322]
Selenium	DM25CGV	N. A.	N. A.	Approved	[214]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[212]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[186]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[195]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[227]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[212]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[212]
Trihexyphenidyl	DMB19L8	Dystonia	8A02	Approved	[212]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[212]

Drug(s) Affected By Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform (PPP2R2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[241]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[318]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[196]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[189]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[597]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[598]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[354]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[249]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[191]

Drug(s) Affected By Transcription factor A, mitochondrial (TFAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[599]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[600]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[454]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[81]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[601]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[319]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[602]
Zalcitabine	DMH7MUV	Human immunodeficiency virus infection	1C62	Approved	[603]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[604]

Drug(s) Affected By Caveolin-1 (CAV1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[497]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[266]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[520]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[605]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[606]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[607]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[608]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[609]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[101]

Drug(s) Affected By Peroxisome proliferator-activated receptor delta (PPARD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[298]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[610]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[95]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[195]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[611]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[148]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[612]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[100]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[101]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]

Drug(s) Affected By Interleukin-24 (IL24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[363]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[212]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[210]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[212]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[212]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[613]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[186]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[218]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[212]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[218]

Drug(s) Affected By Phospholipase D1 (PLD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[614]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[76]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[186]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[241]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[148]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[101]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[196]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[615]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[352]

Drug(s) Affected By Integrin-linked protein kinase (ILK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[144]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[561]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[294]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[609]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[151]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[315]

Drug(s) Affected By Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[616]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[502]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[617]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[618]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[619]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[148]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[586]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[591]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[101]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[300]

Drug(s) Affected By Eukaryotic translation initiation factor 4E-binding protein 2 (EIF4EBP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[218]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[218]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[364]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[81]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[620]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[101]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[196]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[218]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[621]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase FKBP8 (FKBP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[286]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[76]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[218]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[218]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[83]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[151]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[109]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[375]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[622]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[623]

Drug(s) Affected By Ribosomal protein S6 kinase alpha-2 (RPS6KA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[110]
Selenium	DM25CGV	N. A.	N. A.	Approved	[144]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[108]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[148]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[101]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[196]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[624]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[625]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[354]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[249]

Drug(s) Affected By GTP-binding protein Rheb (RHEB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[196]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[151]
Lonafarnib	DMGM2Z6	Hutchinson-Gilford progeria syndrome	LD2B	Approved	[626]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[191]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[627]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[626]
Zarnestra	DMF30HL	Acute myeloid leukaemia	2A60	Phase 3	[626]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[628]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[381]

Drug(s) Affected By Ribosomal protein S6 kinase alpha-1 (RPS6KA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[142]
Selenium	DM25CGV	N. A.	N. A.	Approved	[144]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[76]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[99]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[99]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[151]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[629]

Drug(s) Affected By Serine/threonine-protein kinase STK11 (STK11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[487]
Selenium	DM25CGV	N. A.	N. A.	Approved	[144]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[630]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[631]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[317]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[632]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[633]
GDC-0980/RG7422	DMF3MV1	Non-hodgkin lymphoma	2B33.5	Phase 2	[634]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[628]

Drug(s) Affected By Adiponectin (ADIPOQ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[259]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[259]
Ramipril	DM2R68E	Acute heart failure	BD10-BD13	Approved	[635]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[636]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[259]
Cilazapril	DM4V6JA	Congestive heart failure	BD10	Approved	[637]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[638]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[259]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[639]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[612]

Drug(s) Affected By Hypoxia-inducible factor 1-alpha (HIF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[640]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[641]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[642]
Triamterene	DM2HU9I	Congestive heart failure	BD10	Approved	[642]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[643]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[644]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[645]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[646]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[107]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[492]

Drug(s) Affected By PTB-containing, cubilin and LRP1-interacting protein (PID1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[212]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[212]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[212]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[212]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[212]
Amikacin	DM5PDRB	Bacteremia	1A73	Approved	[212]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[212]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[212]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[212]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[101]

Drug(s) Affected By Regulatory-associated protein of mTOR (RPTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[110]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[647]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[151]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[233]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[249]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[111]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[317]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[648]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[649]

Drug(s) Affected By Proprotein convertase subtilisin/kexin type 9 (PCSK9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[76]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[114]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[372]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[101]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[196]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[650]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[189]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[651]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[154]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[652]

Drug(s) Affected By Intelectin-1 (ITLN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[111]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[235]
Diphenylpyraline	DMW4X37	Allergic rhinitis	CA08.0	Approved	[653]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[184]

Drug(s) Affected By Type II iodothyronine deiodinase (DIO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[363]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[654]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[655]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[656]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[306]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[615]
Ergocalciferol	DMHO0AR	Hypoparathyroidism	5A50	Approved	[657]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[189]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]

Drug(s) Affected By DNA damage-inducible transcript 4-like protein (DDIT4L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[189]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[658]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[319]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[311]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[318]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[659]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[184]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[320]

Drug(s) Affected By Tribbles homolog 3 (TRIB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[279]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[114]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[660]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[331]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[661]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[276]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[331]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[148]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[662]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[364]

Drug(s) Affected By Fibroblast growth factor 21 (FGF21)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[101]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[663]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[664]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[665]
Famotidine	DMRL3AB	Gastric ulcer	DA60	Approved	[666]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[346]
Lansoprazole	DMXYLQ3	Gastric ulcer	DA60	Approved	[666]
Bezafibrate	DMZDCS0	Hypercholesterolaemia	5C80.0	Approved	[663]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[667]

Drug(s) Affected By DNA damage-inducible transcript 4 protein (DDIT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[279]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[614]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[402]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[161]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[76]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[668]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[661]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[150]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[669]

Drug(s) Affected By Cystine/glutamate transporter (SLC7A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[298]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[212]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[404]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[212]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[212]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[306]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[670]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[76]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[331]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[212]

Drug(s) Affected By Telomere length regulation protein TEL2 homolog (TELO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[151]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[249]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[317]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[671]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[671]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[184]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[320]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[406]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[406]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Peroxisome proliferator-activated receptor gamma (PPAR-gamma)	TTZMAO3	PPARG_HUMAN	Agonist	[5]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4) Main DME	DE4LYSA	CP3A4_HUMAN	Substrate	[6]
Cytochrome P450 2C9 (CYP2C9)	DE5IED8	CP2C9_HUMAN	Substrate	[7]
Cytochrome P450 2C8 (CYP2C8) Main DME	DES5XRU	CP2C8_HUMAN	Substrate	[8]
Prostaglandin G/H synthase 1 (COX-1)	DE073H6	PGH1_HUMAN	Substrate	[9]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (HSD3B2)	OT02MSKN	3BHS2_HUMAN	Gene/Protein Processing	[10]
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)	OTRT3F3U	HMDH_HUMAN	Gene/Protein Processing	[11]
Acetyl-CoA acetyltransferase, cytosolic (ACAT2)	OTZ092ZJ	THIC_HUMAN	Gene/Protein Processing	[12]
Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)	OTJC60Q7	THIL_HUMAN	Gene/Protein Processing	[13]
Adiponectin (ADIPOQ)	OTNX23LE	ADIPO_HUMAN	Gene/Protein Processing	[14]
Alternative prion protein (PRNP)	OTE85L1Q	APRIO_HUMAN	Gene/Protein Processing	[15]
Amyloid-beta precursor protein (APP)	OTKFD7R4	A4_HUMAN	Gene/Protein Processing	[16]
Angiopoietin-related protein 4 (ANGPTL4)	OTQL5SPX	ANGL4_HUMAN	Gene/Protein Processing	[12]
Ankyrin repeat domain-containing protein SOWAHC (SOWAHC)	OTI86ECP	SWAHC_HUMAN	Gene/Protein Processing	[12]
AP-1 complex subunit sigma-2 (AP1S2)	OTZHJFYI	AP1S2_HUMAN	Gene/Protein Processing	[12]

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