Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMNOKBV)

Drug Name
Phenytoin Drug Info
Synonyms
Aleviatin; Antisacer; Auranile; Causoin; Citrullamon; Citrulliamon; Comital; Comitoina; Convul; Danten; Dantinal; Dantoinal; Dantoine; Denyl; Difenilhidantoina; Difenin; Difetoin; Difhydan; Dihycon; Dihydantoin; Dilabid; Dilantin; Dilantine; Dillantin; Dintoin; Dintoina; Diphantoin; Diphedal; Diphedan; Diphenat; Diphenin; Diphenine; Diphentoin; Diphentyn; Diphenylan; Diphenylhydantoin; Diphenylhydantoine; Diphenylhydatanoin; Ditoinate; Ekko; Elepsindon; Enkelfel; Epamin; Epanutin; Epelin; Epifenyl; Epihydan; Epilantin; Epinat; Epised; Eptal; Eptoin; Fenitoin; Fenitoina; Fentoin; Fenylepsin; Fenytoine; Hidan; Hidantal; Hidantilo; Hidantina; Hidantomin; Hindatal; Hydantal; Hydantin; Hydantoinal; Hydantol; Idantoil; Idantoin; Iphenylhydantoin; Kessodanten; Labopal; Lehydan; Lepitoin; Lepsin; Minetoin; Neosidantoina; Novantoina; Novophenytoin; Oxylan; PHENYTEK; Phanantin; Phanatine; Phenatine; Phenatoine; Phenhydan; Phenhydanin; Phenitoin; Phentoin; Phentytoin; Phenytex; Phenytoine; Phenytoinum; Ritmenal; Saceril; Sanepil; Silantin; Sinergina; Sodanthon; Sodantoin; Sodanton; Solantin; Solantoin; Solantyl; Sylantoic;TOIN; Tacosal; Thilophenyl; Zentronal; Zentropil; Component of Mebroin; Dantoinal klinos; Difenilhidantoina [Spanish]; Dihydan toin; Dilantin acid; Diphenylhydantoine [French]; Ekko capsules; Elepsi ndon; Epdantoin Simple; Epdantoine simple; Epilan D; Extended Phenytoin Sodium; Fen toin; Fenantoin Mn Pharma; Fenidantoin s; Fenytoin Dak; Hidantina senosian; Hidantina vitoria; Ictalis simp le; Ictalis simple; Om hidantoina simple; Phenat ine; Phenytoin AWD; Sodium Diphenylhydantoinate; Taco sal; Toin unicelles; CL12003; D 4007; D4007_SIGMA; Didan TDC 250; Epasmir 5; IFLab1_000214; DILANTIN-30; DPH (VAN); Di-Hydan; Di-Lan; Di-Phetine; Dilantin (TN); Dilantin Infatabs (TN); Dilantin Kapseals (TN); Dilantin-125; Diphenylhydantoin (VAN); Epanutin (TN); Epasmir (5); Epilan-D; Eptoin (TN); Fenidantoin (s); Fenitoina [INN-Spanish]; Neos-Hidantoina; Om-Hydantoine; PHENYTOIN SODIUM, EXTENDED; Phenytek (TN); Phenytoin (PHN); Phenytoin-Gerot; Phenytoine [INN-French]; Phenytoinum [INN-Latin]; Di-Lan (VAN); Didan-tdc-250; Gerot-epilan-D; PHENYTOIN (5,5-DIPHENYLHYDANTOIN); Phenytoin (JP15/USP/INN); Phenytoin [USAN:INN:BAN:JAN]; Hydantoin, 5,5-diphenyl-(8CI); 2,4-Imidazolidinedione, 5,5-diphenyl-(9CI); 2-hydroxy-5,5-diphenyl-3,5-dihydro-4H-imidazol-4-one; 5,5-DIPHENYLHYDANTOIN; 5,5-Diphenyl-2,4-imidazolidinedione; 5,5-Diphenyl-imidazolidine-2,4-dione; 5,5-Diphenylhydantoin (IUPAC); 5,5-Diphenylhydantoin (phenytoin); 5,5-Diphenylimidazolidin-2,4-dione; 5,5-Dwufenylohydantoina; 5,5-Dwufenylohydantoina [Polish]; 5,5-diphenylimidazolidine-2,4-dione
Indication
Disease Entry ICD 11 Status REF
Epilepsy 8A60-8A68 Approved [1]
Epilepsy with generalized tonic-clonic seizures Approved [2]
Focal epilepsy Approved [2]
Primary motor cortex epilepsy Approved [2]
Therapeutic Class
Anticonvulsants
Cross-matching ID
PubChem CID
1775
ChEBI ID
CHEMBL16
CAS Number
CAS 57-41-0
TTD Drug ID
DMNOKBV
VARIDT Drug ID
DR00431
INTEDE Drug ID
DR1282
ACDINA Drug ID
D00529

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Preclinical Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Sodium channel unspecific (NaC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [16]
Zonisamide DM0DTF7 Alcohol dependence 6C40.2 Approved [17]
Eslicarbazepine DMZREFQ Seizure disorder 8A6Z Approved [18]
LIDOFLAZINE DMV23GL Angina pectoris BA40 Approved [19]
LOMERIZINE DME0TC8 Migraine 8A80 Approved [20]
Levobupivacaine DM783CH Anaesthesia 9A78.6 Approved [21]
Tetrodotoxin DMWMPRG Bacterial infection 1A00-1C4Z Approved [22]
Permethrin DMZ0Q1G Pediculus capitis infestation 1G00.0 Approved [23]
Rufinamide DMWE60C Epilepsy 8A60-8A68 Approved [24]
Butacaine DM584TM Pain MG30-MG3Z Approved [25]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By Multidrug resistance-associated protein 1 (ABCC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [26]
Methotrexate DM2TEOL Anterior urethra cancer Approved [27]
Folic Acid DMEMBJC Colorectal carcinoma Approved [28]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [29]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [30]
Verapamil DMA7PEW Angina pectoris BA40 Approved [31]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [32]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [33]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [34]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [31]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By Multidrug resistance-associated protein 2 (ABCC2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [35]
Methotrexate DM2TEOL Anterior urethra cancer Approved [36]
Folic Acid DMEMBJC Colorectal carcinoma Approved [37]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [38]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [39]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [40]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [41]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [42]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [43]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [44]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [31]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [45]
Methotrexate DM2TEOL Anterior urethra cancer Approved [46]
Folic Acid DMEMBJC Colorectal carcinoma Approved [47]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [46]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [46]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [48]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [46]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [49]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [50]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [51]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [52]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [53]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [54]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [55]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [56]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [57]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [58]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [52]
Verapamil DMA7PEW Angina pectoris BA40 Approved [59]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Glutathione S-transferase alpha-1 (GSTA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [60]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [61]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [62]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [63]
Trabectedin DMG3Y89 Leiomyosarcoma 2B58 Approved [64]
Busulfan DMXYJ9C Chronic myelogenous leukaemia 2A20.0 Approved [65]
Artemisinin DMOY7W3 Malaria 1F40-1F45 Approved [66]
Ethacrynic acid DM60QMR Edema MG29 Approved [67]
Tacrine DM51FY6 Alzheimer disease 8A20 Approved [68]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [69]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 3A5 (CYP3A5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [70]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [71]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [72]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [73]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [74]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [75]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [76]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [77]
Verapamil DMA7PEW Angina pectoris BA40 Approved [78]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [73]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 3A7 (CYP3A7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [79]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [73]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [73]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [73]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [10]
Verapamil DMA7PEW Angina pectoris BA40 Approved [80]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [73]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [73]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [73]
Metronidazole DMTIVEN Abscess Approved [81]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 2C18 (CYP2C18)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [10]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [82]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [83]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [84]
Diazepam DM08E9O Alcohol withdrawal Approved [85]
Methadone DMTW6IU Advanced cancer 2A00-2F9Z Approved [86]
Dapsone DM4LT8A Acne vulgaris ED80 Approved [87]
Lidocaine DML4ZOT Anaesthesia 9A78.6 Approved [10]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [88]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [89]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 2C8 (CYP2C8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [90]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [91]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [91]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [10]
Verapamil DMA7PEW Angina pectoris BA40 Approved [92]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [93]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [94]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [91]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [95]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [83]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [96]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [97]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [98]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [10]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [99]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [10]
Verapamil DMA7PEW Angina pectoris BA40 Approved [100]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [101]
Estrone DM5T6US Acne vulgaris ED80 Approved [102]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [103]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 2B6 (CYP2B6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [104]
Verapamil DMA7PEW Angina pectoris BA40 Approved [10]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [105]
Estrone DM5T6US Acne vulgaris ED80 Approved [98]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [106]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [107]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [108]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [109]
Amitriptyline DMK7F9S Depression 6A70-6A7Z Approved [110]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [10]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Mephenytoin 4-hydroxylase (CYP2C19)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [111]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [96]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [112]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [113]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [10]
Verapamil DMA7PEW Angina pectoris BA40 Approved [114]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [82]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [103]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [115]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [83]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 2C19 (CYP2C19)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [116]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [117]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [118]
Chloramphenicol DMFXEWT Bacterial infection 1A00-1C4Z Approved [119]
Capsaicin DMGMF6V Back pain ME84.Z Approved [120]
Pentamidine DMHZJCG African trypanosomiasis 1F51 Approved [121]
Stiripentol DMMSDOY Dravet syndrome 8A61.11 Approved [122]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [121]
Desipramine DMT2FDC Attention deficit hyperactivity disorder 6A05.Z Approved [117]
Amitriptyline DMK7F9S Depression 6A70-6A7Z Approved [123]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [124]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [125]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [126]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [127]
Cepharanthine DM9Y5JB N. A. N. A. Approved [128]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [129]
Clozapine DMFC71L Schizophrenia 6A20 Approved [130]
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [131]
Trifluoperazine DMKBYWI Anxiety Approved [132]
Olanzapine DMPFN6Y Bipolar depression Approved [130]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By HLA class I histocompatibility antigen, C alpha chain (HLA-C)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [133]
Allopurinol DMLPAOB Gout FA25 Approved [134]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [135]
Ticlopidine DMO946V Acute coronary syndrome BA41 Approved [136]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [137]
Selenium DM25CGV N. A. N. A. Approved [138]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [139]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [140]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [141]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [142]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [143]
Vidarabine DM0N85H Hepatosplenic T-cell lymphoma Approved [143]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [144]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [145]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [146]
Etidronic acid DM1XHYJ Bone Paget disease Approved [143]
Tiaprofenic acid DM23D7J Osteoarthritis FA00-FA05 Approved [143]
Bromperidol DM24XYQ Schizophrenia 6A20 Approved [143]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [147]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [148]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Neurocan core protein (NCAN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [149]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Arsenic DMTL2Y1 N. A. N. A. Approved [151]
PDX-101 DM6OC53 Plasma cell myeloma 2A83.1 Phase 2 [152]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [153]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [154]
Deguelin DMXT7WG Esophageal squamous cell carcinoma 2E60.1 Investigative [155]
⏷ Show the Full List of 7 Drug(s)
Drug(s) Affected By Plexin-B2 (PLXNB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [138]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [156]
Quercetin DM3NC4M Obesity 5B81 Approved [157]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [158]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [159]
Arsenic DMTL2Y1 N. A. N. A. Approved [160]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [161]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [162]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [163]
Adenine DMZLHKJ Malnutrition 5B50-5B71 Approved [156]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Calpain-5 (CAPN5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Leflunomide DMR8ONJ Arthritis FA20 Approved [164]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [165]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [158]
Ethanol DMDRQZU Chronic pain MG30 Approved [166]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [167]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [168]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [169]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [170]
Arsenic DMTL2Y1 N. A. N. A. Approved [160]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [163]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Leucine-rich repeat transmembrane protein FLRT2 (FLRT2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Panobinostat DM58WKG Chronic graft versus host disease Approved [152]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [165]
Testosterone enanthate DMB6871 N. A. N. A. Approved [171]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [158]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [167]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [172]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [173]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [174]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [175]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [176]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Lathosterol oxidase (SC5D)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [177]
Fluoxetine DM3PD2C Bipolar depression Approved [178]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [179]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [180]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [181]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [182]
Testosterone DM7HUNW Hot flushes GA30 Approved [183]
Haloperidol DM96SE0 Delirium Approved [182]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [184]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [185]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Eomesodermin homolog (EOMES)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [186]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [187]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [185]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [188]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [169]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [189]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [190]
Arsenic DMTL2Y1 N. A. N. A. Approved [191]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [135]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [176]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Metalloproteinase inhibitor 1 (TIMP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Pentoxifylline DMU3DNC Alcoholic hepatitis DB94.1 Approved [123]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [192]
Verapamil DMA7PEW Angina pectoris BA40 Approved [193]
Selenium DM25CGV N. A. N. A. Approved [194]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [193]
Quercetin DM3NC4M Obesity 5B81 Approved [195]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [179]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [139]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [196]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [197]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Myc proto-oncogene protein (MYC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [198]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [199]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [200]
Gefitinib DM15F0X Colon adenocarcinoma Approved [201]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [202]
Selenium DM25CGV N. A. N. A. Approved [203]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [204]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [205]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [206]
Methotrexate DM2TEOL Anterior urethra cancer Approved [207]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Collagen alpha-1(I) chain (COL1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [123]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [208]
Diazepam DM08E9O Alcohol withdrawal Approved [209]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [210]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [211]
Methotrexate DM2TEOL Anterior urethra cancer Approved [212]
Ceruletide DM2WE5K Caerulein stimulated gastric and pancreatic secretion 5A4Y Approved [213]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [214]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [215]
Quercetin DM3NC4M Obesity 5B81 Approved [216]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interstitial collagenase (MMP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [217]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [218]
Etretinate DM2CZFA Keratosis ED56 Approved [219]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [220]
Methotrexate DM2TEOL Anterior urethra cancer Approved [221]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [222]
Quercetin DM3NC4M Obesity 5B81 Approved [223]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [224]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [225]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [202]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Creatine kinase M-type (CKM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [226]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [227]
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [228]
Salbutamol DMN9CWF Acute asthma CA23 Approved [229]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [230]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [231]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [228]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [232]
Carbimazole DMULAI4 Hyperthyroidism 5A02 Approved [233]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [228]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Collagen alpha-2(I) chain (COL1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [234]
Panobinostat DM58WKG Chronic graft versus host disease Approved [152]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [227]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [235]
Aldosterone DM9S2JW Hypertension BA00-BA04 Approved [236]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [237]
Testosterone enanthate DMB6871 N. A. N. A. Approved [171]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [158]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [159]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [238]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Chymotrypsin-like elastase family member 2A (CELA2A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [202]
Arsenic DMTL2Y1 N. A. N. A. Approved [160]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [163]
Drug(s) Affected By Stromelysin-1 (MMP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [123]
Fluvastatin DM4MDJY Arteriosclerosis BD40 Approved [123]
Pravastatin DM6A0X7 Adult acute monocytic leukemia Approved [123]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [123]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [239]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [240]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [220]
Methotrexate DM2TEOL Anterior urethra cancer Approved [241]
Quercetin DM3NC4M Obesity 5B81 Approved [242]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [224]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Small ribosomal subunit protein uS2 (RPSA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [243]
Quercetin DM3NC4M Obesity 5B81 Approved [244]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [234]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [245]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [246]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [159]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [247]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [170]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [248]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [249]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Annexin A4 (ANXA4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [177]
Quercetin DM3NC4M Obesity 5B81 Approved [250]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [149]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [251]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [252]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [159]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [253]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [254]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [169]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [238]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Homeobox protein Hox-B7 (HOXB7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [149]
Polyethylene glycol DM4I1JP Constipation DD91.1 Approved [255]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [255]
Nilotinib DM7HXWT Chronic myelogenous leukaemia 2A20.0 Approved [255]
Ramelteon DM7IW9J Insomnia 7A00-7A0Z Approved [255]
Testosterone enanthate DMB6871 N. A. N. A. Approved [171]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [185]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [169]
Abacavir DMMN36E Human immunodeficiency virus infection 1C62 Approved [255]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [256]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transforming growth factor beta-3 proprotein (TGFB3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Diazepam DM08E9O Alcohol withdrawal Approved [209]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [257]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [177]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [179]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [258]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [259]
Testosterone DM7HUNW Hot flushes GA30 Approved [260]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [261]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [260]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [165]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fibroblast growth factor 5 (FGF5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [262]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [263]
Arsenic DMTL2Y1 N. A. N. A. Approved [264]
Ardeparin DMYRX8B Deep vein thrombosis BD71 Approved [265]
Warfarin DMJYCVW Atrial fibrillation BC81.3 Approved [266]
Paclitaxel DMLB81S Breast carcinoma Approved [267]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [267]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [268]
Suramin DMTOUY9 African trypanosomiasis 1F51 Phase 1 [269]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [153]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Collagen alpha-1(XI) chain (COL11A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [149]
Panobinostat DM58WKG Chronic graft versus host disease Approved [270]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [271]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [235]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [272]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [185]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [262]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [169]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [273]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [274]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Collagen alpha-1(VI) chain (COL6A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [275]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [275]
Panobinostat DM58WKG Chronic graft versus host disease Approved [152]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [184]
Testosterone enanthate DMB6871 N. A. N. A. Approved [171]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [158]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [159]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [276]
Paclitaxel DMLB81S Breast carcinoma Approved [277]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [275]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Collagen alpha-2(VI) chain (COL6A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [278]
Selenium DM25CGV N. A. N. A. Approved [138]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [181]
Testosterone enanthate DMB6871 N. A. N. A. Approved [171]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [158]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [276]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [254]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [169]
Paclitaxel DMLB81S Breast carcinoma Approved [277]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [238]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Collagen alpha-3(VI) chain (COL6A3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [181]
Panobinostat DM58WKG Chronic graft versus host disease Approved [152]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [227]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [279]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [272]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [158]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [169]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [238]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [280]
Arsenic DMTL2Y1 N. A. N. A. Approved [160]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interferon gamma receptor 1 (IFNGR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [239]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [177]
Methotrexate DM2TEOL Anterior urethra cancer Approved [221]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [180]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [281]
Leflunomide DMR8ONJ Arthritis FA20 Approved [164]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [272]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [158]
Clozapine DMFC71L Schizophrenia 6A20 Approved [282]
Pentamidine DMHZJCG African trypanosomiasis 1F51 Approved [283]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Methylated-DNA--protein-cysteine methyltransferase (MGMT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [284]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [285]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [286]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [184]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [287]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [159]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [288]
Dacarbazine DMNPZL4 Adenocarcinoma 2D40 Approved [289]
Topotecan DMP6G8T Central nervous system neoplasm Approved [290]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [290]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Homeobox protein Hox-B9 (HOXB9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [177]
Methotrexate DM2TEOL Anterior urethra cancer Approved [291]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [180]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [245]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [255]
Nilotinib DM7HXWT Chronic myelogenous leukaemia 2A20.0 Approved [255]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [184]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [158]
Dabigatran DMDI6R4 Stroke 8B20 Approved [255]
Abacavir DMMN36E Human immunodeficiency virus infection 1C62 Approved [255]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [292]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [293]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [199]
Gefitinib DM15F0X Colon adenocarcinoma Approved [294]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [137]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [295]
Methotrexate DM2TEOL Anterior urethra cancer Approved [296]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [297]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [298]
Quercetin DM3NC4M Obesity 5B81 Approved [299]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Midkine (MDK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [138]
Quercetin DM3NC4M Obesity 5B81 Approved [157]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [300]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [301]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [251]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [158]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [253]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [169]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [238]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [302]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Paired box protein Pax-3 (PAX3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [303]
Polyethylene glycol DM4I1JP Constipation DD91.1 Approved [255]
Panobinostat DM58WKG Chronic graft versus host disease Approved [152]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [255]
Nilotinib DM7HXWT Chronic myelogenous leukaemia 2A20.0 Approved [255]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [252]
Dabigatran DMDI6R4 Stroke 8B20 Approved [255]
Folic Acid DMEMBJC Colorectal carcinoma Approved [304]
Abacavir DMMN36E Human immunodeficiency virus infection 1C62 Approved [255]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [189]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Paired box protein Pax-6 (PAX6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [149]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [255]
Panobinostat DM58WKG Chronic graft versus host disease Approved [152]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [255]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [305]
Nilotinib DM7HXWT Chronic myelogenous leukaemia 2A20.0 Approved [255]
Ramelteon DM7IW9J Insomnia 7A00-7A0Z Approved [255]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [184]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [306]
Dabigatran DMDI6R4 Stroke 8B20 Approved [255]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein S100-A4 (S100A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [307]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [149]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [181]
Panobinostat DM58WKG Chronic graft versus host disease Approved [152]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [308]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [309]
Adenosine triphosphate DM79F6G Malnutrition 5B50-5B71 Approved [310]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [235]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [251]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [158]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [311]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [312]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [313]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [314]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [315]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [316]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [317]
Gefitinib DM15F0X Colon adenocarcinoma Approved [318]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [319]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [320]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [321]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [312]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [322]
Paclitaxel DMLB81S Breast carcinoma Approved [323]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [324]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [311]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [123]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [239]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [314]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [315]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fibroblast growth factor 9 (FGF9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [325]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [149]
Panobinostat DM58WKG Chronic graft versus host disease Approved [152]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [185]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [326]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [262]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [327]
Arsenic DMTL2Y1 N. A. N. A. Approved [160]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [328]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [152]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Keratin, type II cytoskeletal 2 epidermal (KRT2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [210]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [210]
Testosterone DM7HUNW Hot flushes GA30 Approved [260]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [260]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [159]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [273]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [329]
DNCB DMDTVYC Immune System disease 4A01-4B41 Phase 2 [330]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [153]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [331]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [332]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [333]
Gefitinib DM15F0X Colon adenocarcinoma Approved [334]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [335]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [336]
Etretinate DM2CZFA Keratosis ED56 Approved [337]
Prednisone DM2HG4X Acute asthma CA23 Approved [338]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [339]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [156]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Collagen alpha-1(XVIII) chain (COL18A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [278]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [177]
Selenium DM25CGV N. A. N. A. Approved [138]
Quercetin DM3NC4M Obesity 5B81 Approved [157]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [234]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [184]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [158]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [159]
Capsaicin DMGMF6V Back pain ME84.Z Approved [340]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [326]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Large ribosomal subunit protein eL28 (RPL28)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [157]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [158]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [159]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [172]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [329]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [176]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [341]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [138]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [153]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [342]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Microtubule-associated protein 1B (MAP1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [343]
Quercetin DM3NC4M Obesity 5B81 Approved [157]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [149]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [227]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [344]
Leflunomide DMR8ONJ Arthritis FA20 Approved [164]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [157]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [185]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [159]
Folic Acid DMEMBJC Colorectal carcinoma Approved [345]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (PIP4K2A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [346]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [347]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [251]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [185]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [159]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [169]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [348]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [231]
Arsenic DMTL2Y1 N. A. N. A. Approved [160]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [232]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Homeobox protein MOX-1 (MEOX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [210]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [255]
Polyethylene glycol DM4I1JP Constipation DD91.1 Approved [255]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [255]
Panobinostat DM58WKG Chronic graft versus host disease Approved [152]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [349]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [255]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [281]
Nilotinib DM7HXWT Chronic myelogenous leukaemia 2A20.0 Approved [255]
Ramelteon DM7IW9J Insomnia 7A00-7A0Z Approved [255]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Small ribosomal subunit protein mS29 (DAP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [180]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [184]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [350]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [351]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [159]
Menthol DMG2KW7 Back pain ME84.Z Approved [352]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [353]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [169]
Bortezomib DMNO38U Leukemia Approved [354]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [355]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein S100-A10 (S100A10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [180]
Panobinostat DM58WKG Chronic graft versus host disease Approved [152]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [356]
Adenosine triphosphate DM79F6G Malnutrition 5B50-5B71 Approved [310]
Testosterone DM7HUNW Hot flushes GA30 Approved [260]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [260]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [251]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [185]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [159]
Folic Acid DMEMBJC Colorectal carcinoma Approved [345]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Disintegrin and metalloproteinase domain-containing protein 8 (ADAM8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [291]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [234]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [235]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [158]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [169]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [231]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [357]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [153]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [278]
Deguelin DMXT7WG Esophageal squamous cell carcinoma 2E60.1 Investigative [155]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor Sp3 (SP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [358]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [358]
Plicamycin DM7C8YV Hypercalcaemia 5B91.0 Approved [359]
Leflunomide DMR8ONJ Arthritis FA20 Approved [164]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [360]
Promegestone DMK4S8I Gynecological disease GA6Z Approved [361]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [362]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [363]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [163]
Vitamin C DMXJ7O8 Adenocarcinoma 2D40 Approved [364]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fibromodulin (FMOD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Diazepam DM08E9O Alcohol withdrawal Approved [209]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [177]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [349]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [152]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [163]
Methotrexate DM2TEOL Anterior urethra cancer Approved [267]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [267]
Urethane DM7NSI0 N. A. N. A. Phase 4 [365]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [270]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [153]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor 15 (TCF15)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [255]
Polyethylene glycol DM4I1JP Constipation DD91.1 Approved [255]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [255]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [255]
Nilotinib DM7HXWT Chronic myelogenous leukaemia 2A20.0 Approved [255]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [255]
Dabigatran DMDI6R4 Stroke 8B20 Approved [255]
Abacavir DMMN36E Human immunodeficiency virus infection 1C62 Approved [255]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [255]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [153]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Phosphatidate phosphatase LPIN1 (LPIN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [138]
Fluoxetine DM3PD2C Bipolar depression Approved [178]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [179]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [168]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [139]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [181]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [184]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [158]
Ethanol DMDRQZU Chronic pain MG30 Approved [366]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [367]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Signal transducer and activator of transcription 4 (STAT4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [207]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [368]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [281]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [165]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [152]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [368]
Prednisolone DMQ8FR2 Acute adrenal insufficiency Approved [368]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [190]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [368]
Arsenic DMTL2Y1 N. A. N. A. Approved [151]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear receptor subfamily 1 group I member 3 (NR1I3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [147]
Quercetin DM3NC4M Obesity 5B81 Approved [369]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [370]
Artemether DM48QOT Malaria 1F40-1F45 Approved [371]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [372]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [373]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [374]
Estrone DM5T6US Acne vulgaris ED80 Approved [375]
Leflunomide DMR8ONJ Arthritis FA20 Approved [376]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [184]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Oligodendrocyte transcription factor 3 (OLIG3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [255]
Polyethylene glycol DM4I1JP Constipation DD91.1 Approved [255]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [255]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [255]
Nilotinib DM7HXWT Chronic myelogenous leukaemia 2A20.0 Approved [255]
Ramelteon DM7IW9J Insomnia 7A00-7A0Z Approved [255]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [189]
Dabigatran DMDI6R4 Stroke 8B20 Approved [255]
Ethanol DMDRQZU Chronic pain MG30 Approved [166]
Abacavir DMMN36E Human immunodeficiency virus infection 1C62 Approved [255]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sodium channel protein type 2 subunit alpha (SCN2A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [377]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [378]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [349]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [377]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [379]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [165]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [142]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [169]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [380]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [153]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Eyes absent homolog 1 (EYA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [278]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [234]
Polyethylene glycol DM4I1JP Constipation DD91.1 Approved [255]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [255]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [255]
Nilotinib DM7HXWT Chronic myelogenous leukaemia 2A20.0 Approved [255]
Ramelteon DM7IW9J Insomnia 7A00-7A0Z Approved [255]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [255]
Dabigatran DMDI6R4 Stroke 8B20 Approved [255]
Abacavir DMMN36E Human immunodeficiency virus infection 1C62 Approved [255]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Neurogenin-2 (NEUROG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [234]
Polyethylene glycol DM4I1JP Constipation DD91.1 Approved [255]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [255]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [255]
Nilotinib DM7HXWT Chronic myelogenous leukaemia 2A20.0 Approved [255]
Leflunomide DMR8ONJ Arthritis FA20 Approved [164]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [158]
Dabigatran DMDI6R4 Stroke 8B20 Approved [255]
Folic Acid DMEMBJC Colorectal carcinoma Approved [189]
Abacavir DMMN36E Human immunodeficiency virus infection 1C62 Approved [255]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sodium channel protein type 3 subunit alpha (SCN3A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [377]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [158]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [153]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [381]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [154]
Drug(s) Affected By Death-associated protein kinase 2 (DAPK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [139]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [382]
Testosterone DM7HUNW Hot flushes GA30 Approved [260]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [260]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [158]
Menthol DMG2KW7 Back pain ME84.Z Approved [352]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [274]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [231]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [383]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [190]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Structural maintenance of chromosomes protein 3 (SMC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [157]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [149]
Testosterone DM7HUNW Hot flushes GA30 Approved [183]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [184]
Testosterone enanthate DMB6871 N. A. N. A. Approved [171]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [188]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [159]
Bortezomib DMNO38U Leukemia Approved [367]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [302]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [161]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glutathione S-transferase kappa 1 (GSTK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [210]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [384]
Quercetin DM3NC4M Obesity 5B81 Approved [157]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [184]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [159]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [231]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [172]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [256]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [329]
Isoflavone DM7U58J N. A. N. A. Phase 4 [385]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Adiponectin receptor protein 2 (ADIPOR2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [207]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [180]
Leflunomide DMR8ONJ Arthritis FA20 Approved [164]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [386]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [231]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [302]
Arsenic DMTL2Y1 N. A. N. A. Approved [160]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [387]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [388]
Urethane DM7NSI0 N. A. N. A. Phase 4 [365]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein kinase C-binding protein NELL1 (NELL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [234]
Panobinostat DM58WKG Chronic graft versus host disease Approved [152]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [158]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [389]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [231]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [390]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [135]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [391]
Chlorothiazide DMLHESP Chronic heart failure BD1Z Approved [392]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [393]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sodium channel subunit beta-1 (SCN1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aspirin DM672AH Acute coronary syndrome BA41 Approved [394]
Testosterone DM7HUNW Hot flushes GA30 Approved [260]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [260]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [184]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [232]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [163]
Urethane DM7NSI0 N. A. N. A. Phase 4 [365]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [395]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Bis(5'-adenosyl)-triphosphatase (FHIT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [157]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [234]
Testosterone enanthate DMB6871 N. A. N. A. Approved [171]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [252]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [396]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [190]
Arsenic DMTL2Y1 N. A. N. A. Approved [160]
Hydralazine DMU8JGH Chronic heart failure BD1Z Approved [397]
Methamphetamine DMPM4SK Anxiety Approved [398]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [399]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sodium channel protein type 1 subunit alpha (SCN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [400]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [377]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [278]
Quercetin DM3NC4M Obesity 5B81 Approved [157]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [149]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [251]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [185]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [401]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [231]
Arsenic DMTL2Y1 N. A. N. A. Approved [160]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dachshund homolog 1 (DACH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [234]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [184]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [185]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [169]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [248]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [402]
Napabucasin DMDZ6Q3 Colorectal cancer 2B91.Z Phase 3 [403]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [152]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [153]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [404]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By V-type proton ATPase subunit d 2 (ATP6V0D2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Panobinostat DM58WKG Chronic graft versus host disease Approved [152]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [251]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [158]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [190]
Urethane DM7NSI0 N. A. N. A. Phase 4 [365]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [405]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [153]
THAPSIGARGIN DMDMQIE N. A. N. A. Preclinical [406]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [407]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [154]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By A disintegrin and metalloproteinase with thrombospondin motifs 20 (ADAMTS20)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [408]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [187]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [172]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [409]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [410]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [270]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [153]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [154]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Probable E3 ubiquitin-protein ligase IRF2BPL (IRF2BPL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [157]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [149]
Leflunomide DMR8ONJ Arthritis FA20 Approved [164]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [251]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [158]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [159]
Ethanol DMDRQZU Chronic pain MG30 Approved [166]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [326]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [248]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [161]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glutathione hydrolase 7 (GGT7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [158]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [190]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [232]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [163]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [123]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [411]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [153]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [412]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [413]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [414]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By cAMP-dependent protein kinase type II-beta regulatory subunit (PRKAR2B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [184]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [158]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [159]
Folic Acid DMEMBJC Colorectal carcinoma Approved [304]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [238]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [190]
Arsenic DMTL2Y1 N. A. N. A. Approved [160]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [172]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [387]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [415]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Sodium channel unspecific (NaC) TTRK8B9 NOUNIPROTAC Blocker [3]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Multidrug resistance-associated protein 2 (ABCC2) DTFI42L MRP2_HUMAN Substrate [4]
Multidrug resistance-associated protein 1 (ABCC1) DTSYQGK MRP1_HUMAN Substrate [5]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [6]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [7]
Cytochrome P450 2C9 (CYP2C9) Main DME DE5IED8 CP2C9_HUMAN Substrate [8]
Glutathione S-transferase alpha-1 (GSTA1) DE4ZHS1 GSTA1_HUMAN Substrate [9]
Mephenytoin 4-hydroxylase (CYP2C19) Main DME DEGTFWK CP2CJ_HUMAN Substrate [10]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Substrate [11]
Cytochrome P450 2B6 (CYP2B6) DEPKLMQ CP2B6_HUMAN Substrate [11]
Cytochrome P450 2C8 (CYP2C8) DES5XRU CP2C8_HUMAN Substrate [10]
Cytochrome P450 3A7 (CYP3A7) DERD86B CP3A7_HUMAN Substrate [11]
Cytochrome P450 2C18 (CYP2C18) DEZMWRE CP2CI_HUMAN Substrate [10]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
A disintegrin and metalloproteinase with thrombospondin motifs 20 (ADAMTS20) OTU0EKLN ATS20_HUMAN Drug Response [12]
Adiponectin receptor protein 2 (ADIPOR2) OT2HDTL8 PAQR2_HUMAN Drug Response [12]
Annexin A4 (ANXA4) OTUCRYXL ANXA4_HUMAN Gene/Protein Processing [13]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Regulation of Drug Effects [14]
Bis(5'-adenosyl)-triphosphatase (FHIT) OTGWBSLA FHIT_HUMAN Drug Response [12]
Calpain-5 (CAPN5) OTQ8QM7K CAN5_HUMAN Gene/Protein Processing [13]
cAMP-dependent protein kinase type II-beta regulatory subunit (PRKAR2B) OTZEXEFH KAP3_HUMAN Drug Response [12]
Chymotrypsin-like elastase family member 2A (CELA2A) OTY8QG2J CEL2A_HUMAN Gene/Protein Processing [13]
Collagen alpha-1(I) chain (COL1A1) OTI31178 CO1A1_HUMAN Gene/Protein Processing [15]
Collagen alpha-1(VI) chain (COL6A1) OTYKSCOB CO6A1_HUMAN Gene/Protein Processing [13]

References

1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2 Phenytoin FDA Label
3 Lacosamide: a new approach to target voltage-gated sodium currents in epileptic disorders. CNS Drugs. 2009;23(7):555-68.
4 Upregulation of brain expression of P-glycoprotein in MRP2-deficient TR(-) rats resembles seizure-induced up-regulation of this drug efflux transporter in normal rats. Epilepsia. 2007 Apr;48(4):631-45.
5 Evaluation of transport of common antiepileptic drugs by human multidrug resistance-associated proteins (MRP1, 2 and 5) that are overexpressed in pharmacoresistant epilepsy. Neuropharmacology. 2010 Jun;58(7):1019-32.
6 The transport of antiepileptic drugs by P-glycoprotein. Adv Drug Deliv Rev. 2012 Jul;64(10):930-42.
7 Coadministration of lopinavir/ritonavir and phenytoin results in two-way drug interaction through cytochrome P-450 induction. J Acquir Immune Defic Syndr. 2004 Aug 15;36(5):1034-40.
8 Antiepileptic drug interactions - principles and clinical implications. Curr Neuropharmacol. 2010 Sep;8(3):254-67.
9 Comparison of basal glutathione S-transferase activities and of the influence of phenobarbital, butylated hydroxy-anisole or 5,5'-diphenylhydantoin on enzyme activity in male rodents. Comp Biochem Physiol C. 1987;88(1):91-3.
10 Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448.
11 PharmGKB summary: phenytoin pathway. Pharmacogenet Genomics. 2012 Jun;22(6):466-70.
12 Genome-wide mapping for clinically relevant predictors of lamotrigine- and phenytoin-induced hypersensitivity reactions. Pharmacogenomics. 2012 Mar;13(4):399-405. doi: 10.2217/pgs.11.165.
13 Role of phenytoin in wound healing: microarray analysis of early transcriptional responses in human dermal fibroblasts. Biochem Biophys Res Commun. 2004 Feb 13;314(3):661-6. doi: 10.1016/j.bbrc.2003.12.146.
14 CYP2C9, CYP2C19, ABCB1 (MDR1) genetic polymorphisms and phenytoin metabolism in a Black Beninese population. Pharmacogenet Genomics. 2005 Nov;15(11):779-86.
15 Interleukin-1 beta and phenytoin reduce alpha 1 (I) procollagen mRNA expression in human gingival fibroblasts. J Periodontal Res. 1996 Nov;31(8):563-9. doi: 10.1111/j.1600-0765.1996.tb00521.x.
16 Sidedness of carbamazepine accessibility to voltage-gated sodium channels. Mol Pharmacol. 2014 Feb;85(2):381-7.
17 Antiepileptic drugs and relapse after epilepsy surgery. Epileptic Disord. 2008 Sep;10(3):193-8.
18 Progress report on new antiepileptic drugs: a summary of the Ninth Eilat Conference (EILAT IX). Epilepsy Res. 2009 Jan;83(1):1-43.
19 Synthesis and pharmacological evaluation of phenylacetamides as sodium-channel blockers. J Med Chem. 1994 Jan 21;37(2):268-74.
20 Medicinal chemistry of neuronal voltage-gated sodium channel blockers. J Med Chem. 2001 Jan 18;44(2):115-37.
21 Block of neuronal tetrodotoxin-resistant Na+ currents by stereoisomers of piperidine local anesthetics. Anesth Analg. 2000 Dec;91(6):1499-505.
22 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
23 In vitro assays for repellents and deterrents for ticks: differing effects of products when tested with attractant or arrestment stimuli. Med Vet Entomol. 2003 Dec;17(4):370-8.
24 Emerging drugs for epilepsy. Expert Opin Emerg Drugs. 2007 Sep;12(3):407-22.
25 WO patent application no. 2008,0857,11, Synergy of sodium channel blockers and calcium channel blockers.
26 The role of bioreductive activation of doxorubicin in cytotoxic activity against leukaemia HL60-sensitive cell line and its multidrug-resistant sublines. Br J Cancer. 2005 Jul 11;93(1):89-97.
27 Transport of methotrexate (MTX) and folates by multidrug resistance protein (MRP) 3 and MRP1: effect of polyglutamylation on MTX transport. Cancer Res. 2001 Oct 1;61(19):7225-32.
28 Folate concentration dependent transport activity of the Multidrug Resistance Protein 1 (ABCC1). Biochem Pharmacol. 2004 Apr 15;67(8):1541-8.
29 Hammerhead ribozyme against gamma-glutamylcysteine synthetase sensitizes human colonic cancer cells to cisplatin by down-regulating both the glutathione synthesis and the expression of multidrug resistance proteins. Cancer Gene Ther. 2001 Oct;8(10):803-14.
30 Multidrug resistance-associated protein-1 functional activity in Calu-3 cells. J Pharmacol Exp Ther. 2001 Sep;298(3):1199-205.
31 Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007.
32 ATP-Dependent efflux of CPT-11 and SN-38 by the multidrug resistance protein (MRP) and its inhibition by PAK-104P. Mol Pharmacol. 1999 May;55(5):921-8.
33 Structural determinants of substrate specificity differences between human multidrug resistance protein (MRP) 1 (ABCC1) and MRP3 (ABCC3). Drug Metab Dispos. 2008 Dec;36(12):2571-81.
34 Vinblastine and sulfinpyrazone export by the multidrug resistance protein MRP2 is associated with glutathione export. Br J Cancer. 2000 Aug;83(3):375-83.
35 Involvement of the drug transporters p glycoprotein and multidrug resistance-associated protein Mrp2 in telithromycin transport. Antimicrob Agents Chemother. 2006 Jan;50(1):80-7.
36 Dose-dependent disposition of methotrexate in Abcc2 and Abcc3 gene knockout murine models. Drug Metab Dispos. 2011 Nov;39(11):2155-61.
37 Mammalian multidrug-resistance proteins (MRPs). Essays Biochem. 2011 Sep 7;50(1):179-207.
38 Enhancing chemosensitivity in oral squamous cell carcinoma by lentivirus vector-mediated RNA interference targeting EGFR and MRP2. Oncol Lett. 2016 Sep;12(3):2107-2114.
39 Multidrug resistance associated protein 2 mediates transport of prostaglandin E2. Liver Int. 2006 Apr;26(3):362-8.
40 Lentivirus-mediated RNAi silencing targeting ABCC2 increasing the sensitivity of a human nasopharyngeal carcinoma cell line against cisplatin. J Transl Med. 2008 Oct 4;6:55.
41 Effect of acetaminophen on expression and activity of rat liver multidrug resistance-associated protein 2 and P-glycoprotein. Biochem Pharmacol. 2004 Aug 15;68(4):791-8.
42 Small intestinal efflux mediated by MRP2 and BCRP shifts sulfasalazine intestinal permeability from high to low, enabling its colonic targeting. Am J Physiol Gastrointest Liver Physiol. 2009 Aug;297(2):G371-7.
43 Delineating the contribution of secretory transporters in the efflux of etoposide using Madin-Darby canine kidney (MDCK) cells overexpressing P-glycoprotein (Pgp), multidrug resistance-associated protein (MRP1), and canalicular multispecific organic anion transporter (cMOAT). Drug Metab Dispos. 2002 Apr;30(4):457-63.
44 Multidrug Resistance-Associated Protein 2 (MRP2) Mediated Transport of Oxaliplatin-Derived Platinum in Membrane Vesicles. PLoS One. 2015 Jul 1;10(7):e0130727.
45 MDR1 (ABCB1) G1199A (Ser400Asn) polymorphism alters transepithelial permeability and sensitivity to anticancer agents. Cancer Chemother Pharmacol. 2009 Jun;64(1):183-8.
46 Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64.
47 Folate transporter expression decreases in the human placenta throughout pregnancy and in pre-eclampsia. Pregnancy Hypertens. 2012 Apr;2(2):123-31.
48 Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein. Pharm Res. 2001 Dec;18(12):1660-8.
49 Antiestrogens and steroid hormones: substrates of the human P-glycoprotein. Biochem Pharmacol. 1994 Jul 19;48(2):287-92.
50 Association of genetic polymorphisms in the influx transporter SLCO1B3 and the efflux transporter ABCB1 with imatinib pharmacokinetics in patients with chronic myeloid leukemia. Ther Drug Monit. 2011 Apr;33(2):244-50.
51 Expression levels and activation of a PXR variant are directly related to drug resistance in osteosarcoma cell lines. Cancer. 2007 Mar 1;109(5):957-65.
52 Contribution of human hepatic cytochrome P450 isoforms to regioselective hydroxylation of steroid hormones. Xenobiotica. 1998 Jun;28(6):539-47.
53 Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: prominent roles for CYP3A and CYP2D6. J Pharmacol Exp Ther. 2004 Sep;310(3):1062-75.
54 Isoform-specific regulation of cytochromes P450 expression by estradiol and progesterone. Drug Metab Dispos. 2013 Feb;41(2):263-9.
55 Metabolic interactions between acetaminophen (paracetamol) and two flavonoids, luteolin and quercetin, through in-vitro inhibition studies. J Pharm Pharmacol. 2017 Dec;69(12):1762-1772.
56 Potent mechanism-based inhibition of CYP3A4 by imatinib explains its liability to interact with CYP3A4 substrates. Br J Pharmacol. 2012 Apr;165(8):2787-98.
57 Effects of morin on the pharmacokinetics of etoposide in rats. Biopharm Drug Dispos. 2007 Apr;28(3):151-6.
58 The metabolism of zidovudine by human liver microsomes in vitro: formation of 3'-amino-3'-deoxythymidine. Biochem Pharmacol. 1994 Jul 19;48(2):267-76.
59 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
60 Role of glutathione S-transferase P1-1 in the cellular detoxification of cisplatin. Mol Cancer Ther. 2008 Oct;7(10):3247-55.
61 Human glutathione transferase A3-3, a highly efficient catalyst of double-bond isomerization in the biosynthetic pathway of steroid hormones. J Biol Chem. 2001 Aug 31;276(35):33061-5.
62 Retinoid X receptor alpha regulates the expression of glutathione s-transferase genes and modulates acetaminophen-glutathione conjugation in mouse liver. Mol Pharmacol. 2005 Dec;68(6):1590-6.
63 Characterization and formation of the glutathione conjugate of clofibric acid. Drug Metab Dispos. 1995 Jan;23(1):119-23.
64 In vitro characterization of the human biotransformation and CYP reaction phenotype of ET-743 (Yondelis, Trabectidin), a novel marine anti-cancer drug. Invest New Drugs. 2006 Jan;24(1):3-14.
65 Glutathione S-transferase M1 polymorphism: a risk factor for hepatic venoocclusive disease in bone marrow transplantation. Blood. 2004 Sep 1;104(5):1574-7.
66 Inhibition of glutathione S-transferases by antimalarial drugs possible implications for circumventing anticancer drug resistance. Int J Cancer. 2002 Feb 10;97(5):700-5.
67 Purification and biochemical properties of glutathione S-transferase from Lactuca sativa. J Biochem Mol Biol. 2005 Mar 31;38(2):232-7.
68 Combined glutathione-S-transferase M1 and T1 genetic polymorphism and tacrine hepatotoxicity. Clin Pharmacol Ther. 2000 Apr;67(4):432-7.
69 Metabolism of melphalan by rat liver microsomal glutathione S-transferase. Chem Biol Interact. 2005 Apr 15;152(2-3):101-6.
70 Drug related genetic polymorphisms affecting adverse reactions to methotrexate, vinblastine, doxorubicin and cisplatin in patients with urothelial cancer. J Urol. 2008 Dec;180(6):2389-95.
71 Human prostate CYP3A5: identification of a unique 5'-untranslated sequence and characterization of purified recombinant protein. Biochem Biophys Res Commun. 1999 Jul 14;260(3):676-81.
72 Polymorphisms in cytochrome P4503A5 (CYP3A5) may be associated with race and tumor characteristics, but not metabolism and side effects of tamoxifen in breast cancer patients. Cancer Lett. 2005 Jan 10;217(1):61-72.
73 Drug Interactions Flockhart Table
74 Induction of hepatic CYP2E1 by a subtoxic dose of acetaminophen in rats: increase in dichloromethane metabolism and carboxyhemoglobin elevation. Drug Metab Dispos. 2007 Oct;35(10):1754-8.
75 Urinary 6 beta-hydroxycortisol excretion in rheumatoid arthritis. Br J Rheumatol. 1997 Jan;36(1):54-8.
76 Clinical pharmacokinetics of imatinib. Clin Pharmacokinet. 2005;44(9):879-94.
77 Kinetics and regulation of cytochrome P450-mediated etoposide metabolism. Drug Metab Dispos. 2004 Sep;32(9):993-1000.
78 Differential mechanism-based inhibition of CYP3A4 and CYP3A5 by verapamil. Drug Metab Dispos. 2005 May;33(5):664-71.
79 The role of cytochrome P450 3A (CYP3A) isoform(s) in oxidative metabolism of testosterone and benzphetamine in human adult and fetal liver. J Steroid Biochem Mol Biol. 1993 Jan;44(1):61-7.
80 Prediction of cytochrome P450 3A inhibition by verapamil enantiomers and their metabolites. Drug Metab Dispos. 2004 Feb;32(2):259-66.
81 The role of human cytochrome P450 enzymes in the formation of 2-hydroxymetronidazole: CYP2A6 is the high affinity (low Km) catalyst. Drug Metab Dispos. 2013 Sep;41(9):1686-94.
82 Diclofenac and its derivatives as tools for studying human cytochromes P450 active sites: particular efficiency and regioselectivity of P450 2Cs. Biochemistry. 1999 Oct 26;38(43):14264-70.
83 Possible involvement of multiple human cytochrome P450 isoforms in the liver metabolism of propofol. Br J Anaesth. 1998 Jun;80(6):788-95.
84 Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites. Mol Pharmacol. 2000 Dec;58(6):1341-8.
85 Targeted antipeptide antibodies to cytochrome P450 2C18 based on epitope mapping of an inhibitory monoclonal antibody to P450 2C51. Arch Biochem Biophys. 1997 Feb 15;338(2):157-64.
86 Involvement of cytochrome P450 3A4 enzyme in the N-demethylation of methadone in human liver microsomes. Chem Res Toxicol. 1996 Mar;9(2):365-73.
87 CYP2C8/9 mediate dapsone N-hydroxylation at clinical concentrations of dapsone. Drug Metab Dispos. 2000 Aug;28(8):865-8.
88 Induction of CYP2C genes in human hepatocytes in primary culture. Drug Metab Dispos. 2001 Mar;29(3):242-51.
89 Development of a substrate-activity based approach to identify the major human liver P-450 catalysts of cyclophosphamide and ifosfamide activation based on cDNA-expressed activities and liver microsomal P-450 profiles. Drug Metab Dispos. 1999 Jun;27(6):655-66.
90 Roles of cytochromes P450 1A2, 2A6, and 2C8 in 5-fluorouracil formation from tegafur, an anticancer prodrug, in human liver microsomes. Drug Metab Dispos. 2000 Dec;28(12):1457-63.
91 Role of cytochrome P450 2C8 in drug metabolism and interactions. Pharmacol Rev. 2016 Jan;68(1):168-241.
92 Differential expression and function of CYP2C isoforms in human intestine and liver. Pharmacogenetics. 2003 Sep;13(9):565-75.
93 Analysis of human cytochrome P450 2C8 substrate specificity using a substrate pharmacophore and site-directed mutants. Biochemistry. 2004 Dec 14;43(49):15379-92.
94 Interaction of sorafenib and cytochrome P450 isoenzymes in patients with advanced melanoma: a phase I/II pharmacokinetic interaction study. Cancer Chemother Pharmacol. 2011 Nov;68(5):1111-8.
95 PharmGKB summary: mycophenolic acid pathway. Pharmacogenet Genomics. 2014 Jan;24(1):73-9.
96 Progesterone and testosterone hydroxylation by cytochromes P450 2C19, 2C9, and 3A4 in human liver microsomes. Arch Biochem Biophys. 1997 Oct 1;346(1):161-9.
97 Tamoxifen inhibits cytochrome P450 2C9 activity in breast cancer patients. J Chemother. 2006 Aug;18(4):421-4.
98 Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms. Endocrinology. 2003 Aug;144(8):3382-98.
99 Drug-drug interactions with imatinib: an observational study. Medicine (Baltimore). 2016 Oct;95(40):e5076.
100 Drug interactions with calcium channel blockers: possible involvement of metabolite-intermediate complexation with CYP3A. Drug Metab Dispos. 2000 Feb;28(2):125-30.
101 New insights into the structural features and functional relevance of human cytochrome P450 2C9. Part I. Curr Drug Metab. 2009 Dec;10(10):1075-126.
102 A potential role for the estrogen-metabolizing cytochrome P450 enzymes in human breast carcinogenesis. Breast Cancer Res Treat. 2003 Dec;82(3):191-7.
103 A mechanistic approach to antiepileptic drug interactions. Ann Pharmacother. 1998 May;32(5):554-63.
104 Effect of tamoxifen on the enzymatic activity of human cytochrome CYP2B6. J Pharmacol Exp Ther. 2002 Jun;301(3):945-52.
105 Hepatic metabolism of diclofenac: role of human CYP in the minor oxidative pathways. Biochem Pharmacol. 1999 Sep 1;58(5):787-96.
106 Insights into CYP2B6-mediated drug-drug interactions. Acta Pharm Sin B. 2016 Sep;6(5):413-425.
107 Drugs that may have potential CYP2B6 interactions.
108 Involvement of human cytochrome P450 2B6 in the omega- and 4-hydroxylation of the anesthetic agent propofol. Xenobiotica. 2007 Jul;37(7):717-24.
109 Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-butanone metabolism by cytochrome P450 2B6. Drug Metab Dispos. 2005 Dec;33(12):1760-4.
110 Application of the relative activity factor approach in scaling from heterologously expressed cytochromes p450 to human liver microsomes: studies on amitriptyline as a model substrate. J Pharmacol Exp Ther. 2001 Apr;297(1):326-37.
111 High-dose rabeprazole/amoxicillin therapy as the second-line regimen after failure to eradicate H. pylori by triple therapy with the usual doses of a proton pump inhibitor, clarithromycin and amoxicillin. Hepatogastroenterology. 2003 Nov-Dec;50(54):2274-8.
112 Cytochrome P450 pharmacogenetics and cancer. Oncogene. 2006 Mar 13;25(11):1679-91.
113 CYP2C19*17 is associated with decreased breast cancer risk. Breast Cancer Res Treat. 2009 May;115(2):391-6.
114 Cytochromes of the P450 2C subfamily are the major enzymes involved in the O-demethylation of verapamil in humans. Naunyn Schmiedebergs Arch Pharmacol. 1995 Dec;353(1):116-21.
115 Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33.
116 Characterization of the structural determinants required for potent mechanism-based inhibition of human cytochrome P450 1A1 by cannabidiol. Chem Biol Interact. 2014 May 25;215:62-8.
117 Inhibition of cytochrome P450 enzymes participating in p-nitrophenol hydroxylation by drugs known as CYP2E1 inhibitors. Chem Biol Interact. 2004 Apr 15;147(3):331-40.
118 The novel azole R126638 is a selective inhibitor of ergosterol synthesis in Candida albicans, Trichophyton spp., and Microsporum canis. Antimicrob Agents Chemother. 2004 Sep;48(9):3272-8.
119 Cytochrome P450 inhibition potential of new psychoactive substances of the tryptamine class. Toxicol Lett. 2016 Jan 22;241:82-94.
120 Effects of capsaicin and dihydrocapsaicin on human and rat liver microsomal CYP450 enzyme activities in vitro and in vivo. J Asian Nat Prod Res. 2012;14(4):382-95.
121 Application of higher throughput screening (HTS) inhibition assays to evaluate the interaction of antiparasitic drugs with cytochrome P450s. Drug Metab Dispos. 2001 Jan;29(1):30-5.
122 Stiripentol. Expert Opin Investig Drugs. 2005 Jul;14(7):905-11.
123 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
124 Characteristics of P388/VMDRC.04, a simple, sensitive model for studying P-glycoprotein antagonists. Cancer Res. 1994 Feb 1;54(3):730-7.
125 Michaelis-Menten kinetic analysis of drugs of abuse to estimate their affinity to human P-glycoprotein. Toxicol Lett. 2013 Feb 27;217(2):137-42. doi: 10.1016/j.toxlet.2012.12.012. Epub 2012 Dec 27.
126 Editor's Highlight: PlacentalDisposition and Effects of Crizotinib: An Ex Vivo Study in the Isolated Dual-Side Perfused Human Cotyledon. Toxicol Sci. 2017 Jun 1;157(2):500-509. doi: 10.1093/toxsci/kfx063.
127 Functional evaluation of polymorphisms in the human ABCB1 gene and the impact on clinical responses of antiepileptic drugs. Pharmacogenet Genomics. 2008 May;18(5):390-402. doi: 10.1097/FPC.0b013e3282f85e36.
128 Cepharanthine potently enhances the sensitivity of anticancer agents in K562 cells. Cancer Sci. 2005 Jun;96(6):372-6. doi: 10.1111/j.1349-7006.2005.00057.x.
129 Clinical pharmacokinetic monitoring of itraconazole is warranted in only a subset of patients. Ther Drug Monit. 2005 Jun;27(3):322-33. doi: 10.1097/01.ftd.0000150135.22645.ea.
130 Evaluation of antipsychotic drugs as inhibitors of multidrug resistance transporter P-glycoprotein. Psychopharmacology (Berl). 2006 Sep;187(4):415-23. doi: 10.1007/s00213-006-0437-9. Epub 2006 Jun 30.
131 Actions of the selective protein kinase C inhibitor PKC412 on B-chronic lymphocytic leukemia cells in vitro. Haematologica. 2002 Feb;87(2):167-76.
132 Characterization of the ATPase activity of the Mr 170,000 to 180,000 membrane glycoprotein (P-glycoprotein) associated with multidrug resistance in K562/ADM cells. Cancer Res. 1988 Sep 1;48(17):4926-32.
133 Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions. Pharmacogenet Genomics. 2006 Apr;16(4):297-306. doi: 10.1097/01.fpc.0000199500.46842.4a.
134 A study of HLA class I and class II 4-digit allele level in Stevens-Johnson syndrome and toxic epidermal necrolysis. Int J Immunogenet. 2011 Aug;38(4):303-9. doi: 10.1111/j.1744-313X.2011.01011.x. Epub 2011 May 4.
135 Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen. Clin Pharmacol Ther. 2016 Apr;99(4):432-41.
136 Ticlopidine-induced hepatotoxicity is associated with specific human leukocyte antigen genomic subtypes in Japanese patients: a preliminary case-control study. Pharmacogenomics J. 2008 Feb;8(1):29-33. doi: 10.1038/sj.tpj.6500442. Epub 2007 Mar 6.
137 Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells. Free Radic Biol Med. 2002 Nov 15;33(10):1419-32.
138 Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
139 Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis. Biochem Pharmacol. 2004 Dec 1;68(11):2177-86.
140 Changes in gene expression profiles of multiple myeloma cells induced by arsenic trioxide (ATO): possible mechanisms to explain ATO resistance in vivo. Br J Haematol. 2005 Mar;128(5):636-44.
141 Cyclosporine A--induced oxidative stress in human renal mesangial cells: a role for ERK 1/2 MAPK signaling. Toxicol Sci. 2012 Mar;126(1):101-13.
142 The neuroprotective action of the mood stabilizing drugs lithium chloride and sodium valproate is mediated through the up-regulation of the homeodomain protein Six1. Toxicol Appl Pharmacol. 2009 Feb 15;235(1):124-34.
143 Screening of a chemical library reveals novel PXR-activating pharmacologic compounds. Toxicol Lett. 2015 Jan 5;232(1):193-202. doi: 10.1016/j.toxlet.2014.10.009. Epub 2014 Oct 16.
144 Induction of PXR-mediated metabolism by beta-carotene. Biochim Biophys Acta. 2005 May 30;1740(2):162-9. doi: 10.1016/j.bbadis.2004.11.013. Epub 2004 Dec 8.
145 Lignans, bacteriocides and organochlorine compounds activate the human pregnane X receptor (PXR). Toxicol Appl Pharmacol. 2005 Dec 1;209(2):123-33. doi: 10.1016/j.taap.2005.03.015.
146 Identification and validation of novel human pregnane X receptor activators among prescribed drugs via ligand-based virtual screening. Drug Metab Dispos. 2011 Feb;39(2):337-44. doi: 10.1124/dmd.110.035808. Epub 2010 Nov 10.
147 Identification of HMG-CoA reductase inhibitors as activators for human, mouse and rat constitutive androstane receptor. Drug Metab Dispos. 2005 Jul;33(7):924-9.
148 Acetylated deoxycholic (DCA) and cholic (CA) acids are potent ligands of pregnane X (PXR) receptor. Toxicol Lett. 2017 Jan 4;265:86-96.
149 Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
150 Design principles of concentration-dependent transcriptome deviations in drug-exposed differentiating stem cells. Chem Res Toxicol. 2014 Mar 17;27(3):408-20.
151 Epigenetic changes in individuals with arsenicosis. Chem Res Toxicol. 2011 Feb 18;24(2):165-7. doi: 10.1021/tx1004419. Epub 2011 Feb 4.
152 A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
153 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
154 From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. Arch Toxicol. 2014 Jul;88(7):1451-68.
155 Neurotoxicity and underlying cellular changes of 21 mitochondrial respiratory chain inhibitors. Arch Toxicol. 2021 Feb;95(2):591-615. doi: 10.1007/s00204-020-02970-5. Epub 2021 Jan 29.
156 Utilization of CDKN1A/p21 gene for class discrimination of DNA damage-induced clastogenicity. Toxicology. 2014 Jan 6;315:8-16. doi: 10.1016/j.tox.2013.10.009. Epub 2013 Nov 6.
157 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
158 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
159 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
160 Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Toxicol Sci. 2015 Jan;143(1):97-106. doi: 10.1093/toxsci/kfu210. Epub 2014 Oct 10.
161 Gene expression analysis of precision-cut human liver slices indicates stable expression of ADME-Tox related genes. Toxicol Appl Pharmacol. 2011 May 15;253(1):57-69.
162 Identification of novel low-dose bisphenol a targets in human foreskin fibroblast cells derived from hypospadias patients. PLoS One. 2012;7(5):e36711. doi: 10.1371/journal.pone.0036711. Epub 2012 May 4.
163 Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
164 Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
165 Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
166 Gene expression signatures after ethanol exposure in differentiating embryoid bodies. Toxicol In Vitro. 2018 Feb;46:66-76.
167 Mifepristone induced progesterone withdrawal reveals novel regulatory pathways in human endometrium. Mol Hum Reprod. 2007 Sep;13(9):641-54.
168 Transcriptomic analysis of untreated and drug-treated differentiated HepaRG cells over a 2-week period. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):27-35.
169 Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
170 DNA methylation inhibits p53-mediated survivin repression. Oncogene. 2009 May 14;28(19):2046-50. doi: 10.1038/onc.2009.62. Epub 2009 Apr 13.
171 Transcriptional profiling of testosterone-regulated genes in the skeletal muscle of human immunodeficiency virus-infected men experiencing weight loss. J Clin Endocrinol Metab. 2007 Jul;92(7):2793-802. doi: 10.1210/jc.2006-2722. Epub 2007 Apr 17.
172 Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
173 Estradiol and selective estrogen receptor modulators differentially regulate target genes with estrogen receptors alpha and beta. Mol Biol Cell. 2004 Mar;15(3):1262-72. doi: 10.1091/mbc.e03-06-0360. Epub 2003 Dec 29.
174 Characterizing the genetic basis for nicotine induced cancer development: a transcriptome sequencing study. PLoS One. 2013 Jun 18;8(6):e67252.
175 Cytosine arabinoside induces ectoderm and inhibits mesoderm expression in human embryonic stem cells during multilineage differentiation. Br J Pharmacol. 2011 Apr;162(8):1743-56.
176 Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay. Toxicol Sci. 2015 Aug;146(2):311-20. doi: 10.1093/toxsci/kfv094. Epub 2015 May 15.
177 Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
178 Screening autism-associated environmental factors in differentiating human neural progenitors with fractional factorial design-based transcriptomics. Sci Rep. 2023 Jun 29;13(1):10519. doi: 10.1038/s41598-023-37488-0.
179 Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
180 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
181 Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May;1(3):177-87.
182 Drug-induced activation of SREBP-controlled lipogenic gene expression in CNS-related cell lines: marked differences between various antipsychotic drugs. BMC Neurosci. 2006 Oct 20;7:69.
183 The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
184 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
185 Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
186 Molecular characterization of a toxicological tipping point during human stem cell differentiation. Reprod Toxicol. 2020 Jan;91:1-13. doi: 10.1016/j.reprotox.2019.10.001. Epub 2019 Oct 7.
187 Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol. 2005 Nov;19(11):2685-95.
188 Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
189 Neuronal and cardiac toxicity of pharmacological compounds identified through transcriptomic analysis of human pluripotent stem cell-derived embryoid bodies. Toxicol Appl Pharmacol. 2021 Dec 15;433:115792. doi: 10.1016/j.taap.2021.115792. Epub 2021 Nov 3.
190 Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
191 Identification of novel gene targets and putative regulators of arsenic-associated DNA methylation in human urothelial cells and bladder cancer. Chem Res Toxicol. 2015 Jun 15;28(6):1144-55. doi: 10.1021/tx500393y. Epub 2015 Jun 3.
192 Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1. FASEB J. 2012 Apr;26(4):1535-48. doi: 10.1096/fj.11-198184. Epub 2011 Dec 23.
193 Discovery of molecular mechanisms of neuroprotection using cell-based bioassays and oligonucleotide arrays. Physiol Genomics. 2002 Oct 29;11(2):45-52. doi: 10.1152/physiolgenomics.00064.2002.
194 Inhibition of invasion and induction of apoptosis by selenium in human malignant brain tumour cells in vitro. Int J Oncol. 2007 May;30(5):1263-71.
195 Dietary supplementation with the anti-tumour promoter quercetin: its effects on matrix metalloproteinase gene regulation. Mutat Res. 2001 Sep 1;480-481:269-76. doi: 10.1016/s0027-5107(01)00184-1.
196 Arsenic trioxide (As2O3) inhibits invasion of HT1080 human fibrosarcoma cells: role of nuclear factor-kappaB and reactive oxygen species. J Cell Biochem. 2005 Aug 1;95(5):955-69. doi: 10.1002/jcb.20452.
197 Aspirin inhibits MMP-2 and MMP-9 expressions and activities through upregulation of PPARalpha/gamma and TIMP gene expressions in ox-LDL-stimulated macrophages derived from human monocytes. Pharmacology. 2009;83(1):18-25. doi: 10.1159/000166183. Epub 2008 Oct 30.
198 Acetaminophen-induced proliferation of estrogen-responsive breast cancer cells is associated with increases in c-myc RNA expression and NF-kappaB activity. Toxicol Sci. 2002 Apr;66(2):233-43. doi: 10.1093/toxsci/66.2.233.
199 Sertraline induces endoplasmic reticulum stress in hepatic cells. Toxicology. 2014 Aug 1;322:78-88. doi: 10.1016/j.tox.2014.05.007. Epub 2014 May 24.
200 Estrogen regulation in human breast cancer cells of new downstream gene targets involved in estrogen metabolism, cell proliferation and cell transformation. J Mol Endocrinol. 2004 Apr;32(2):397-414.
201 ZD1839 induces p15INK4b and causes G1 arrest by inhibiting the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway. Mol Cancer Ther. 2007 May;6(5):1579-87. doi: 10.1158/1535-7163.MCT-06-0814.
202 Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation. Blood. 2005 Jul 1;106(1):304-10.
203 Selenite and selenomethionine promote HL-60 cell cycle progression. J Nutr. 2002 Apr;132(4):674-9. doi: 10.1093/jn/132.4.674.
204 Ribavirin augments doxorubicin's efficacy in human hepatocellular carcinoma through inhibiting doxorubicin-induced eIF4E activation. J Biochem Mol Toxicol. 2018 Jan;32(1). doi: 10.1002/jbt.22007. Epub 2017 Nov 7.
205 Combination small molecule MEK and PI3K inhibition enhances uveal melanoma cell death in a mutant GNAQ- and GNA11-dependent manner. Clin Cancer Res. 2012 Aug 15;18(16):4345-55. doi: 10.1158/1078-0432.CCR-11-3227. Epub 2012 Jun 25.
206 Novel detection and differential utilization of a c-myc transcriptional block in colon cancer chemoprevention. Cancer Res. 2002 Nov 1;62(21):6006-10.
207 The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
208 Investigation of in vitro odonto/osteogenic capacity of cannabidiol on human dental pulp cell. J Dent. 2021 Jun;109:103673. doi: 10.1016/j.jdent.2021.103673. Epub 2021 Apr 16.
209 Patterns of some extracellular matrix gene expression are similar in cells from cleft lip-palate patients and in human palatal fibroblasts exposed to diazepam in culture. Toxicology. 2009 Mar 4;257(1-2):10-6. doi: 10.1016/j.tox.2008.12.002. Epub 2008 Dec 9.
210 Beta-carotene and apocarotenals promote retinoid signaling in BEAS-2B human bronchioepithelial cells. Arch Biochem Biophys. 2006 Nov 1;455(1):48-60.
211 Protective effects of myricitrin against osteoporosis via reducing reactive oxygen species and bone-resorbing cytokines. Toxicol Appl Pharmacol. 2014 Nov 1;280(3):550-60.
212 Gene expression profiling of rheumatoid arthritis synovial cells treated with antirheumatic drugs. J Biomol Screen. 2007 Apr;12(3):328-40. doi: 10.1177/1087057107299261. Epub 2007 Mar 22.
213 Acinar cell-specific knockout of the PTHrP gene decreases the proinflammatory and profibrotic responses in pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2014 Sep 1;307(5):G533-49. doi: 10.1152/ajpgi.00428.2013. Epub 2014 Jul 17.
214 The effects of particulate wear debris, cytokines, and growth factors on the functions of MG-63 osteoblasts. J Bone Joint Surg Am. 2001 Feb;83(2):201-11. doi: 10.2106/00004623-200102000-00007.
215 Inhibition of systemic sclerosis dermal fibroblast type I collagen production and gene expression by simvastatin. Arthritis Rheum. 2006 Apr;54(4):1298-308. doi: 10.1002/art.21723.
216 Antifibrotic effects of quercetin in primary orbital fibroblasts and orbital fat tissue cultures of Graves' orbitopathy. Invest Ophthalmol Vis Sci. 2012 Aug 31;53(9):5921-9. doi: 10.1167/iovs.12-9646.
217 Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells. Toxicol Sci. 2023 Feb 17;191(2):227-238. doi: 10.1093/toxsci/kfac131.
218 Oxidative Stress-Protective and Anti-Melanogenic Effects of Loliolide and Ethanol Extract from Fresh Water Green Algae, Prasiola japonica. Int J Mol Sci. 2018 Sep 18;19(9):2825. doi: 10.3390/ijms19092825.
219 The effects of a novel synthetic retinoid, seletinoid G, on the expression of extracellular matrix proteins in aged human skin in vivo. Clin Chim Acta. 2005 Dec;362(1-2):161-9. doi: 10.1016/j.cccn.2005.06.016. Epub 2005 Aug 1.
220 Ciprofloxacin enhances the stimulation of matrix metalloproteinase 3 expression by interleukin-1beta in human tendon-derived cells. A potential mechanism of fluoroquinolone-induced tendinopathy. Arthritis Rheum. 2002 Nov;46(11):3034-40. doi: 10.1002/art.10617.
221 Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells. Tumour Biol. 2011 Oct;32(5):965-76.
222 Simvastatin reduces MMP1 expression in human smooth muscle cells cultured on polymerized collagen by inhibiting Rac1 activation. Arterioscler Thromb Vasc Biol. 2007 May;27(5):1043-9. doi: 10.1161/ATVBAHA.107.139881. Epub 2007 Feb 15.
223 Quercetin inhibits matrix metalloproteinase-1 expression in human vascular endothelial cells through extracellular signal-regulated kinase. Arch Biochem Biophys. 2001 Jul 1;391(1):72-8. doi: 10.1006/abbi.2001.2402.
224 Rofecoxib regulates the expression of genes related to the matrix metalloproteinase pathway in humans: implication for the adverse effects of cyclooxygenase-2 inhibitors. Clin Pharmacol Ther. 2006 Apr;79(4):303-15. doi: 10.1016/j.clpt.2005.12.306.
225 Interaction between the aryl hydrocarbon receptor and retinoic acid pathways increases matrix metalloproteinase-1 expression in keratinocytes. J Biol Chem. 2004 Jun 11;279(24):25284-93. doi: 10.1074/jbc.M402168200. Epub 2004 Apr 9.
226 [Muscular damage during isotretinoin treatment]. Ann Dermatol Venereol. 1998 Feb;125(2):94-7.
227 Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
228 Identification of genomic biomarkers for anthracycline-induced cardiotoxicity in human iPSC-derived cardiomyocytes: an in vitro repeated exposure toxicity approach for safety assessment. Arch Toxicol. 2016 Nov;90(11):2763-2777.
229 Elevation of creatine kinase from skeletal muscle associated with inhaled albuterol. Ann Allergy Asthma Immunol. 1996 Dec;77(6):488-90. doi: 10.1016/S1081-1206(10)63356-X.
230 Cell death mechanisms of the anti-cancer drug etoposide on human cardiomyocytes isolated from pluripotent stem cells. Arch Toxicol. 2018 Apr;92(4):1507-1524.
231 Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
232 Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: application to acetaminophen injury. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):270-80.
233 Myositis in association with carbimazole therapy. Lancet. 1989 Apr 29;1(8644):964. doi: 10.1016/s0140-6736(89)92550-6.
234 Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
235 Identification of vitamin D3 target genes in human breast cancer tissue. J Steroid Biochem Mol Biol. 2016 Nov;164:90-97.
236 Modelling cardiac fibrosis using three-dimensional cardiac microtissues derived from human embryonic stem cells. J Biol Eng. 2019 Feb 13;13:15. doi: 10.1186/s13036-019-0139-6. eCollection 2019.
237 Primary Human Hepatocyte Spheroids as Tools to Study the Hepatotoxic Potential of Non-Pharmaceutical Chemicals. Int J Mol Sci. 2021 Oct 12;22(20):11005. doi: 10.3390/ijms222011005.
238 Identification of mechanisms of action of bisphenol a-induced human preadipocyte differentiation by transcriptional profiling. Obesity (Silver Spring). 2014 Nov;22(11):2333-43.
239 Cannabidiol Modulates the Immunophenotype and Inhibits the Activation of the Inflammasome in Human Gingival Mesenchymal Stem Cells. Front Physiol. 2016 Nov 24;7:559. doi: 10.3389/fphys.2016.00559. eCollection 2016.
240 Unique signatures of stress-induced senescent human astrocytes. Exp Neurol. 2020 Dec;334:113466. doi: 10.1016/j.expneurol.2020.113466. Epub 2020 Sep 17.
241 Reduction of synovial sublining layer inflammation and proinflammatory cytokine expression in psoriatic arthritis treated with methotrexate. Arthritis Rheum. 2004 Oct;50(10):3286-95. doi: 10.1002/art.20518.
242 Quercetin inhibits IL-1-induced proliferation and production of MMPs, COX-2, and PGE2 by rheumatoid synovial fibroblast. Inflammation. 2012 Aug;35(4):1585-94. doi: 10.1007/s10753-012-9473-2.
243 MS4A3-HSP27 target pathway reveals potential for haematopoietic disorder treatment in alimentary toxic aleukia. Cell Biol Toxicol. 2023 Feb;39(1):201-216. doi: 10.1007/s10565-021-09639-4. Epub 2021 Sep 28.
244 Protein expression profiling identifies molecular targets of quercetin as a major dietary flavonoid in human colon cancer cells. Proteomics. 2004 Jul;4(7):2160-74.
245 Gene expression profile induced by arsenic trioxide in chronic lymphocytic leukemia cells reveals a central role for heme oxygenase-1 in apoptosis and regulation of matrix metalloproteinase-9. Oncotarget. 2016 Dec 13;7(50):83359-83377.
246 The differential cancer growth associated with anaesthetics in a cancer xenograft model of mice: mechanisms and implications of postoperative cancer recurrence. Cell Biol Toxicol. 2023 Aug;39(4):1561-1575. doi: 10.1007/s10565-022-09747-9. Epub 2022 Aug 12.
247 Mitochondrial proteomics investigation of a cellular model of impaired dopamine homeostasis, an early step in Parkinson's disease pathogenesis. Mol Biosyst. 2014 Jun;10(6):1332-44.
248 Low doses of cisplatin induce gene alterations, cell cycle arrest, and apoptosis in human promyelocytic leukemia cells. Biomark Insights. 2016 Aug 24;11:113-21.
249 Transcriptional profiling in the human prefrontal cortex: evidence for two activational states associated with cocaine abuse. Pharmacogenomics J. 2003;3(1):27-40.
250 Identification of biomarkers for the initiation of apoptosis in human preneoplastic colonocytes by proteome analysis. Int J Cancer. 2004 Mar 20;109(2):220-9. doi: 10.1002/ijc.11692.
251 Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
252 Stem cell transcriptome responses and corresponding biomarkers that indicate the transition from adaptive responses to cytotoxicity. Chem Res Toxicol. 2017 Apr 17;30(4):905-922.
253 NOTCH signaling is activated in and contributes to resistance in enzalutamide-resistant prostate cancer cells. J Biol Chem. 2019 May 24;294(21):8543-8554. doi: 10.1074/jbc.RA118.006983. Epub 2019 Apr 2.
254 Mitochondrial Uncoupling Induces Epigenome Remodeling and Promotes Differentiation in Neuroblastoma. Cancer Res. 2023 Jan 18;83(2):181-194. doi: 10.1158/0008-5472.CAN-22-1029.
255 Exposure-based assessment of chemical teratogenicity using morphogenetic aggregates of human embryonic stem cells. Reprod Toxicol. 2020 Jan;91:74-91. doi: 10.1016/j.reprotox.2019.10.004. Epub 2019 Nov 8.
256 Genistein and bisphenol A exposure cause estrogen receptor 1 to bind thousands of sites in a cell type-specific manner. Genome Res. 2012 Nov;22(11):2153-62.
257 Arsenite and cadmium promote the development of mammary tumors. Carcinogenesis. 2020 Jul 14;41(7):1005-1014. doi: 10.1093/carcin/bgz176.
258 Retinoic acid receptor alpha amplifications and retinoic acid sensitivity in breast cancers. Clin Breast Cancer. 2013 Oct;13(5):401-8.
259 JunD is involved in the antiproliferative effect of Delta9-tetrahydrocannabinol on human breast cancer cells. Oncogene. 2008 Aug 28;27(37):5033-44.
260 Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
261 Ouabain impairs cell migration, and invasion and alters gene expression of human osteosarcoma U-2 OS cells. Environ Toxicol. 2017 Nov;32(11):2400-2413. doi: 10.1002/tox.22453. Epub 2017 Aug 10.
262 Dasatinib reverses cancer-associated fibroblasts (CAFs) from primary lung carcinomas to a phenotype comparable to that of normal fibroblasts. Mol Cancer. 2010 Jun 27;9:168.
263 Bone marrow osteoblast damage by chemotherapeutic agents. PLoS One. 2012;7(2):e30758. doi: 10.1371/journal.pone.0030758. Epub 2012 Feb 17.
264 Arsenic alters transcriptional responses to Pseudomonas aeruginosa infection and decreases antimicrobial defense of human airway epithelial cells. Toxicol Appl Pharmacol. 2017 Sep 15;331:154-163.
265 Activation of fibroblast growth factor (FGF) receptors by recombinant human FGF-5. Oncogene. 1993 May;8(5):1311-6.
266 Influence of common and rare genetic variation on warfarin dose among African-Americans and European-Americans using the exome array. Pharmacogenomics. 2017 Jul;18(11):1059-1073. doi: 10.2217/pgs-2017-0046. Epub 2017 Jul 7.
267 Gene expression profiling of 30 cancer cell lines predicts resistance towards 11 anticancer drugs at clinically achieved concentrations. Int J Cancer. 2006 Apr 1;118(7):1699-712. doi: 10.1002/ijc.21570.
268 A high concentration of genistein down-regulates activin A, Smad3 and other TGF-beta pathway genes in human uterine leiomyoma cells. Exp Mol Med. 2012 Apr 30;44(4):281-92.
269 Increased expression of fibroblast growth factors (FGFs) and their receptor by protamine and suramin on Kaposi's sarcoma-derived cells. Anticancer Res. 1993 Jul-Aug;13(4):887-90.
270 Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
271 Rofecoxib modulates multiple gene expression pathways in a clinical model of acute inflammatory pain. Pain. 2007 Mar;128(1-2):136-47.
272 Evaluation of a human iPSC-derived BBB model for repeated dose toxicity testing with cyclosporine A as model compound. Toxicol In Vitro. 2021 Jun;73:105112. doi: 10.1016/j.tiv.2021.105112. Epub 2021 Feb 22.
273 CXCL14 downregulation in human keratinocytes is a potential biomarker for a novel in vitro skin sensitization test. Toxicol Appl Pharmacol. 2020 Jan 1;386:114828. doi: 10.1016/j.taap.2019.114828. Epub 2019 Nov 14.
274 Identification by automated screening of a small molecule that selectively eliminates neural stem cells derived from hESCs but not dopamine neurons. PLoS One. 2009 Sep 23;4(9):e7155.
275 Retinoic acid and its 4-oxo metabolites are functionally active in human skin cells in vitro. J Invest Dermatol. 2005 Jul;125(1):143-53.
276 Proteomic analysis of human adipose tissue after rosiglitazone treatment shows coordinated changes to promote glucose uptake. Obesity (Silver Spring). 2010 Jan;18(1):27-34. doi: 10.1038/oby.2009.208. Epub 2009 Jun 25.
277 Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell. 2009 Aug 21;138(4):645-659. doi: 10.1016/j.cell.2009.06.034. Epub 2009 Aug 13.
278 DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.
279 Thyroid hormone responsive genes in cultured human fibroblasts. J Clin Endocrinol Metab. 2005 Feb;90(2):936-43.
280 The effect of DNA methylation inhibitor 5-Aza-2'-deoxycytidine on human endometrial stromal cells. Hum Reprod. 2010 Nov;25(11):2859-69.
281 THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders. Transl Psychiatry. 2018 Apr 25;8(1):89. doi: 10.1038/s41398-018-0137-3.
282 Toxicoproteomics reveals an effect of clozapine on autophagy in human liver spheroids. Toxicol Mech Methods. 2023 Jun;33(5):401-410. doi: 10.1080/15376516.2022.2156005. Epub 2022 Dec 19.
283 Antileishmanial drugs cause up-regulation of interferon-gamma receptor 1, not only in the monocytes of visceral leishmaniasis cases but also in cultured THP1 cells. Ann Trop Med Parasitol. 2003 Apr;97(3):245-57. doi: 10.1179/000349803235001714.
284 Tumor necrosis factor-alpha-induced protein 3 as a putative regulator of nuclear factor-kappaB-mediated resistance to O6-alkylating agents in human glioblastomas. J Clin Oncol. 2006 Jan 10;24(2):274-87. doi: 10.1200/JCO.2005.02.9405. Epub 2005 Dec 19.
285 Comparative gene expression analysis of a chronic myelogenous leukemia cell line resistant to cyclophosphamide using oligonucleotide arrays and response to tyrosine kinase inhibitors. Leuk Res. 2007 Nov;31(11):1511-20.
286 Ouabain induces apoptotic cell death in human prostate DU 145 cancer cells through DNA damage and TRAIL pathways. Environ Toxicol. 2019 Dec;34(12):1329-1339. doi: 10.1002/tox.22834. Epub 2019 Aug 21.
287 Disulfiram is a direct and potent inhibitor of human O6-methylguanine-DNA methyltransferase (MGMT) in brain tumor cells and mouse brain and markedly increases the alkylating DNA damage. Carcinogenesis. 2014 Mar;35(3):692-702. doi: 10.1093/carcin/bgt366. Epub 2013 Nov 5.
288 Induction of the DNA repair gene O6-methylguanine-DNA methyltransferase by dexamethasone in glioblastomas. J Neurosurg. 2004 Oct;101(4):659-63. doi: 10.3171/jns.2004.101.4.0659.
289 Pharmacokinetic, biochemical and clinical effects of dimethyltriazenoimidazole-4-carboxamide-bischloroethylnitrosourea combination therapy in patients with advanced breast cancer. Int J Cancer. 2003 Feb 20;103(5):686-92. doi: 10.1002/ijc.10849.
290 Transcriptional repression of O6-methylguanine DNA methyltransferase gene rendering cells hypersensitive to N,N'-bis(2-chloroethyl)-N-nitrosurea in camptothecin-resistant cells. Mol Pharmacol. 2008 Aug;74(2):517-26. doi: 10.1124/mol.107.043620. Epub 2008 May 20.
291 Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
292 Dexamethasone and the inflammatory response in explants of human omental adipose tissue. Mol Cell Endocrinol. 2010 Feb 5;315(1-2):292-8.
293 DNA array analysis of the effects of aspirin on colon cancer cells: involvement of Rac1. Carcinogenesis. 2004 Jul;25(7):1293-8.
294 Identification of genes linked to gefitinib treatment in prostate cancer cell lines with or without resistance to androgen: a clue to application of gefitinib to hormone-resistant prostate cancer. Oncol Rep. 2006 Jun;15(6):1453-60.
295 The thioredoxin system mediates redox-induced cell death in human colon cancer cells: implications for the mechanism of action of anticancer agents. Cancer Res. 2008 Oct 15;68(20):8269-77. doi: 10.1158/0008-5472.CAN-08-2010.
296 Development of an alternative zebrafish model for drug-induced intestinal toxicity. J Appl Toxicol. 2018 Feb;38(2):259-273. doi: 10.1002/jat.3520. Epub 2017 Oct 13.
297 Response rate of fibrosarcoma cells to cytotoxic drugs on the expression level correlates to the therapeutic response rate of fibrosarcomas and is mediated by regulation of apoptotic pathways. BMC Cancer. 2005 Jul 7;5:74. doi: 10.1186/1471-2407-5-74.
298 Suppression of RAGE as a basis of simvastatin-dependent plaque stabilization in type 2 diabetes. Arterioscler Thromb Vasc Biol. 2006 Dec;26(12):2716-23.
299 Quercetin potentiates apoptosis by inhibiting nuclear factor-kappaB signaling in H460 lung cancer cells. Biol Pharm Bull. 2013;36(6):944-51. doi: 10.1248/bpb.b12-01004.
300 Effects of ciglitazone and troglitazone on the proliferation of human stomach cancer cells. World J Gastroenterol. 2009 Jan 21;15(3):310-20.
301 Constitutive gene expression predisposes morphogen-mediated cell fate responses of NT2/D1 and 27X-1 human embryonal carcinoma cells. Stem Cells. 2007 Mar;25(3):771-8. doi: 10.1634/stemcells.2006-0271. Epub 2006 Nov 30.
302 Apoptosis induced by piroxicam plus cisplatin combined treatment is triggered by p21 in mesothelioma. PLoS One. 2011;6(8):e23569.
303 All-trans-retinoic acid inhibits collapsin response mediator protein-2 transcriptional activity during SH-SY5Y neuroblastoma cell differentiation. FEBS J. 2007 Jan;274(2):498-511. doi: 10.1111/j.1742-4658.2006.05597.x.
304 Folic acid supplementation dysregulates gene expression in lymphoblastoid cells--implications in nutrition. Biochem Biophys Res Commun. 2011 Sep 9;412(4):688-92. doi: 10.1016/j.bbrc.2011.08.027. Epub 2011 Aug 16.
305 hiPSC-Based Model of Prenatal Exposure to Cannabinoids: Effect on Neuronal Differentiation. Front Mol Neurosci. 2020 Jul 6;13:119. doi: 10.3389/fnmol.2020.00119. eCollection 2020.
306 Epigenetic changes and disturbed neural development in a human embryonic stem cell-based model relating to the fetal valproate syndrome. Hum Mol Genet. 2012 Sep 15;21(18):4104-14. doi: 10.1093/hmg/dds239. Epub 2012 Jun 20.
307 Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses. PLoS One. 2010 Dec 17;5(12):e14352. doi: 10.1371/journal.pone.0014352.
308 Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells. Nat Commun. 2018 Aug 9;9(1):3069. doi: 10.1038/s41467-018-05402-2.
309 Lunasin, a novel seed peptide, sensitizes human breast cancer MDA-MB-231 cells to aspirin-arrested cell cycle and induced apoptosis. Chem Biol Interact. 2010 Jul 30;186(2):127-34. doi: 10.1016/j.cbi.2010.04.027. Epub 2010 May 21.
310 Extracellular ATP drives breast cancer cell migration and metastasis via S100A4 production by cancer cells and fibroblasts. Cancer Lett. 2018 Aug 28;430:1-10. doi: 10.1016/j.canlet.2018.04.043. Epub 2018 May 5.
311 Treatment with anticancer agents induces dysregulation of specific Wnt signaling pathways in human ovarian luteinized granulosa cells in vitro. Toxicol Sci. 2013 Nov;136(1):183-92. doi: 10.1093/toxsci/kft175. Epub 2013 Aug 16.
312 Progesterone increases csk homologous kinase in HMC-1560 human mast cells and reduces cell proliferation. J Cell Biochem. 2007 Dec 1;102(5):1271-80. doi: 10.1002/jcb.21357.
313 Cannabidiol upregulates melanogenesis through CB1 dependent pathway by activating p38 MAPK and p42/44 MAPK. Chem Biol Interact. 2017 Aug 1;273:107-114. doi: 10.1016/j.cbi.2017.06.005. Epub 2017 Jun 7.
314 Sertraline, an antidepressant, induces apoptosis in hepatic cells through the mitogen-activated protein kinase pathway. Toxicol Sci. 2014 Feb;137(2):404-15. doi: 10.1093/toxsci/kft254. Epub 2013 Nov 5.
315 Growth stimulation of human pulmonary adenocarcinoma cells and small airway epithelial cells by beta-carotene via activation of cAMP, PKA, CREB and ERK1/2. Int J Cancer. 2006 Mar 15;118(6):1370-80. doi: 10.1002/ijc.21537.
316 Estrogen and pure antiestrogen fulvestrant (ICI 182 780) augment cell-matrigel adhesion of MCF-7 breast cancer cells through a novel G protein coupled estrogen receptor (GPR30)-to-calpain signaling axis. Toxicol Appl Pharmacol. 2014 Mar 1;275(2):176-81. doi: 10.1016/j.taap.2014.01.005. Epub 2014 Jan 17.
317 Inhibition of activator protein 1 by barbiturates is mediated by differential effects on mitogen-activated protein kinases and the small G proteins ras and rac-1. J Pharmacol Exp Ther. 2004 Dec;311(3):1232-40. doi: 10.1124/jpet.104.071332. Epub 2004 Jul 19.
318 Growth of hormone-dependent MCF-7 breast cancer cells is promoted by constitutive caveolin-1 whose expression is lost in an EGF-R-mediated manner during development of tamoxifen resistance. Breast Cancer Res Treat. 2010 Feb;119(3):575-91. doi: 10.1007/s10549-009-0355-8. Epub 2009 Mar 15.
319 Effect of histamine H1 receptor antagonists on TARC/CCL17 and MDC/CCL22 production from CD14+ cells induced by antigenic stimulation in vitro. Int Arch Allergy Immunol. 2011;155(1):38-51. doi: 10.1159/000318720. Epub 2010 Nov 25.
320 SIRT3 Mediates the Antioxidant Effect of Hydrogen Sulfide in Endothelial Cells. Antioxid Redox Signal. 2016 Feb 20;24(6):329-43. doi: 10.1089/ars.2015.6331. Epub 2015 Nov 10.
321 Downregulation of mitogen-activated protein kinases (MAPKs) in chronic ethanol-induced fatty liver. Toxicol Mech Methods. 2020 Jul;30(6):407-416. doi: 10.1080/15376516.2020.1747126. Epub 2020 Apr 1.
322 A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling. Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16657-62. doi: 10.1073/pnas.0707936104. Epub 2007 Oct 9.
323 The stent-eluting drugs sirolimus and paclitaxel suppress healing of the endothelium by induction of autophagy. Am J Pathol. 2009 Nov;175(5):2226-34.
324 Modulation of apoptosis in HaCaT keratinocytes via differential regulation of ERK signaling pathway by flavonoids. J Biol Chem. 2005 Sep 9;280(36):31498-507. doi: 10.1074/jbc.M505537200. Epub 2005 Jul 13.
325 Expression and mitogenic effect of fibroblast growth factor-9 in human endometriotic implant is regulated by aberrant production of estrogen. J Clin Endocrinol Metab. 2003 Nov;88(11):5547-54. doi: 10.1210/jc.2003-030597.
326 Interleukin-19 as a translational indicator of renal injury. Arch Toxicol. 2015 Jan;89(1):101-6.
327 Clinical determinants of response to irinotecan-based therapy derived from cell line models. Clin Cancer Res. 2008 Oct 15;14(20):6647-55.
328 Fibroblast growth factor-9 is an endometrial stromal growth factor. Endocrinology. 2002 Jul;143(7):2715-21. doi: 10.1210/endo.143.7.8900.
329 Expression Profiling of Human Pluripotent Stem Cell-Derived Cardiomyocytes Exposed to Doxorubicin-Integration and Visualization of Multi-Omics Data. Toxicol Sci. 2018 May 1;163(1):182-195. doi: 10.1093/toxsci/kfy012.
330 Proteomic analysis of the cellular response to a potent sensitiser unveils the dynamics of haptenation in living cells. Toxicology. 2020 Dec 1;445:152603. doi: 10.1016/j.tox.2020.152603. Epub 2020 Sep 28.
331 Zidovudine induces S-phase arrest and cell cycle gene expression changes in human cells. Mutagenesis. 2005 Mar;20(2):139-46. doi: 10.1093/mutage/gei019. Epub 2005 Mar 22.
332 Cannabidiol Activates Neuronal Precursor Genes in Human Gingival Mesenchymal Stromal Cells. J Cell Biochem. 2017 Jun;118(6):1531-1546. doi: 10.1002/jcb.25815. Epub 2016 Dec 29.
333 Gene expression profiles with activation of the estrogen receptor alpha-selective estrogen receptor modulator complex in breast cancer cells expressing wild-type estrogen receptor. Cancer Res. 2002 Aug 1;62(15):4419-26.
334 Leptomycin B reduces primary and acquired resistance of gefitinib in lung cancer cells. Toxicol Appl Pharmacol. 2017 Nov 15;335:16-27. doi: 10.1016/j.taap.2017.09.017. Epub 2017 Sep 21.
335 BMN 673 (talazoparib): A potent PARP inhibitor for triple negative breast cancer with different genetic profile. J Biochem Mol Toxicol. 2019 May;33(5):e22286. doi: 10.1002/jbt.22286. Epub 2019 Jan 23.
336 Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells. Cancer Res. 2002 Nov 1;62(21):6246-54.
337 Bexarotene activates the p53/p73 pathway in human cutaneous T-cell lymphoma. Br J Dermatol. 2009 Mar;160(3):519-26. doi: 10.1111/j.1365-2133.2008.08931.x. Epub 2008 Nov 25.
338 Glucocorticoids induce G1 arrest of lymphoblastic cells through retinoblastoma protein Rb1 dephosphorylation in childhood acute lymphoblastic leukemia in vivo. Cancer Biol Ther. 2004 May;3(5):470-6. doi: 10.4161/cbt.3.5.838. Epub 2004 May 9.
339 Ciprofloxacin mediated cell growth inhibition, S/G2-M cell cycle arrest, and apoptosis in a human transitional cell carcinoma of the bladder cell line. Clin Cancer Res. 2000 Mar;6(3):891-900.
340 Capsaicin promotes a more aggressive gene expression phenotype and invasiveness in null-TRPV1 urothelial cancer cells. Carcinogenesis. 2011 May;32(5):686-94. doi: 10.1093/carcin/bgr025. Epub 2011 Feb 10.
341 The molecular basis of genistein-induced mitotic arrest and exit of self-renewal in embryonal carcinoma and primary cancer cell lines. BMC Med Genomics. 2008 Oct 10;1:49.
342 Alternatives for the worse: Molecular insights into adverse effects of bisphenol a and substitutes during human adipocyte differentiation. Environ Int. 2021 Nov;156:106730. doi: 10.1016/j.envint.2021.106730. Epub 2021 Jun 27.
343 Gingival Stromal Cells as an In Vitro Model: Cannabidiol Modulates Genes Linked With Amyotrophic Lateral Sclerosis. J Cell Biochem. 2017 Apr;118(4):819-828. doi: 10.1002/jcb.25757. Epub 2016 Nov 28.
344 Keratinocyte-derived IL-36gama plays a role in hydroquinone-induced chemical leukoderma through inhibition of melanogenesis in human epidermal melanocytes. Arch Toxicol. 2019 Aug;93(8):2307-2320.
345 Folate deficiency in normal human fibroblasts leads to altered expression of genes primarily linked to cell signaling, the cytoskeleton and extracellular matrix. J Nutr Biochem. 2007 Aug;18(8):541-52. doi: 10.1016/j.jnutbio.2006.11.002. Epub 2007 Feb 22.
346 Oxidative stress modulates theophylline effects on steroid responsiveness. Biochem Biophys Res Commun. 2008 Dec 19;377(3):797-802.
347 Delta9-tetrahydrocannabinol inhibits cytotrophoblast cell proliferation and modulates gene transcription. Mol Hum Reprod. 2006 May;12(5):321-33. doi: 10.1093/molehr/gal036. Epub 2006 Apr 5.
348 Identification of biomarkers and outcomes of endocrine disruption in human ovarian cortex using In Vitro Models. Toxicology. 2023 Feb;485:153425. doi: 10.1016/j.tox.2023.153425. Epub 2023 Jan 5.
349 Identification of transcriptome signatures and biomarkers specific for potential developmental toxicants inhibiting human neural crest cell migration. Arch Toxicol. 2016 Jan;90(1):159-80.
350 Plasmatic concentration of organochlorine lindane acts as metabolic disruptors in HepG2 liver cell line by inducing mitochondrial disorder. Toxicol Appl Pharmacol. 2013 Oct 15;272(2):325-34.
351 Gene expression profiling of early primary biliary cirrhosis: possible insights into the mechanism of action of ursodeoxycholic acid. Liver Int. 2008 Aug;28(7):997-1010. doi: 10.1111/j.1478-3231.2008.01744.x. Epub 2008 Apr 15.
352 Repurposing L-menthol for systems medicine and cancer therapeutics? L-menthol induces apoptosis through caspase 10 and by suppressing HSP90. OMICS. 2016 Jan;20(1):53-64.
353 Rosiglitazone sensitizes MDA-MB-231 breast cancer cells to anti-tumour effects of tumour necrosis factor-alpha, CH11 and CYC202. Endocr Relat Cancer. 2007 Jun;14(2):305-15. doi: 10.1677/ERC-06-0003.
354 Bortezomib induces caspase-dependent apoptosis in Hodgkin lymphoma cell lines and is associated with reduced c-FLIP expression: a gene expression profiling study with implications for potential combination therapies. Leuk Res. 2008 Feb;32(2):275-85. doi: 10.1016/j.leukres.2007.05.024. Epub 2007 Jul 19.
355 Increased mitochondrial ROS formation by acetaminophen in human hepatic cells is associated with gene expression changes suggesting disruption of the mitochondrial electron transport chain. Toxicol Lett. 2015 Apr 16;234(2):139-50.
356 Detection of gene expression alteration of myeloma cells treated with arsenic trioxide. Zhonghua Xue Ye Xue Za Zhi. 2005 Apr;26(4):209-13.
357 The MT1G Gene in LUHMES Neurons Is a Sensitive Biomarker of Neurotoxicity. Neurotox Res. 2020 Dec;38(4):967-978. doi: 10.1007/s12640-020-00272-3. Epub 2020 Sep 1.
358 Arsenic trioxide downregulates specificity protein (Sp) transcription factors and inhibits bladder cancer cell and tumor growth. Exp Cell Res. 2010 Aug 1;316(13):2174-88. doi: 10.1016/j.yexcr.2010.04.027. Epub 2010 May 8.
359 The activity of a novel mithramycin analog is related to its binding to DNA, cellular accumulation, and inhibition of Sp1-driven gene transcription. Chem Biol Interact. 2014 Aug 5;219:123-32. doi: 10.1016/j.cbi.2014.05.019. Epub 2014 Jun 4.
360 Nuclear and Mitochondrial DNA Methylation Patterns Induced by Valproic Acid in Human Hepatocytes. Chem Res Toxicol. 2017 Oct 16;30(10):1847-1854. doi: 10.1021/acs.chemrestox.7b00171. Epub 2017 Sep 13.
361 SP1 and SP3 mediate progesterone-dependent induction of the 17beta hydroxysteroid dehydrogenase type 2 gene in human endometrium. Biol Reprod. 2006 Oct;75(4):605-14.
362 Specificity protein 1 (sp1) oscillation is involved in copper homeostasis maintenance by regulating human high-affinity copper transporter 1 expression. Mol Pharmacol. 2012 Mar;81(3):455-64. doi: 10.1124/mol.111.076422. Epub 2011 Dec 15.
363 Transcriptional regulation of neutral sphingomyelinase 2 gene expression of a human breast cancer cell line, MCF-7, induced by the anti-cancer drug, daunorubicin. Biochim Biophys Acta. 2009 Nov-Dec;1789(11-12):681-90. doi: 10.1016/j.bbagrm.2009.08.006. Epub 2009 Aug 19.
364 Pharmacologic doses of ascorbic acid repress specificity protein (Sp) transcription factors and Sp-regulated genes in colon cancer cells. Nutr Cancer. 2011;63(7):1133-42. doi: 10.1080/01635581.2011.605984. Epub 2011 Sep 15.
365 Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.
366 The potential effects of HECTD4 variants on fasting glucose and triglyceride levels in relation to prevalence of type 2 diabetes based on alcohol intake. Arch Toxicol. 2022 Sep;96(9):2487-2499. doi: 10.1007/s00204-022-03325-y. Epub 2022 Jun 17.
367 The proapoptotic effect of zoledronic acid is independent of either the bone microenvironment or the intrinsic resistance to bortezomib of myeloma cells and is enhanced by the combination with arsenic trioxide. Exp Hematol. 2011 Jan;39(1):55-65.
368 Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration. Arthritis Res Ther. 2009;11(1):R15.
369 Bioactive terpenoids and flavonoids from Ginkgo biloba extract induce the expression of hepatic drug-metabolizing enzymes through pregnane X receptor, constitutive androstane receptor, and aryl hydrocarbon receptor-mediated pathways. Pharm Res. 2009 Apr;26(4):872-82.
370 Species-specific toxicity of diclofenac and troglitazone in primary human and rat hepatocytes. Chem Biol Interact. 2009 Apr 15;179(1):17-24.
371 Fetal bovine serum and human constitutive androstane receptor: evidence for activation of the SV23 splice variant by artemisinin, artemether, and arteether in a serum-free cell culture system. Toxicol Appl Pharmacol. 2014 Jun 1;277(2):221-30. doi: 10.1016/j.taap.2014.03.023. Epub 2014 Apr 12.
372 Constitutive androstane/active receptor is a target of retinoic acid receptor in humans. Biochem Pharmacol. 2010 Jul 1;80(1):129-35. doi: 10.1016/j.bcp.2010.02.023. Epub 2010 Mar 6.
373 Robustness testing and optimization of an adverse outcome pathway on cholestatic liver injury. Arch Toxicol. 2020 Apr;94(4):1151-1172. doi: 10.1007/s00204-020-02691-9. Epub 2020 Mar 10.
374 Expression and inducibility of cytochrome P450s (CYP1A1, 2B6, 2E1, 3A4) in human cord blood CD34(+) stem cell-derived differentiating neuronal cells. Toxicol Sci. 2012 Oct;129(2):392-410.
375 Agonistic effects of diverse xenobiotics on the constitutive androstane receptor as detected in a recombinant yeast-cell assay. Toxicol In Vitro. 2018 Feb;46:335-349. doi: 10.1016/j.tiv.2017.09.014. Epub 2017 Sep 18.
376 Teriflunomide is an indirect human constitutive androstane receptor (CAR) activator interacting with epidermal growth factor (EGF) signaling. Front Pharmacol. 2018 Oct 11;9:993.
377 Inhibitory effects of cannabidiol on voltage-dependent sodium currents. J Biol Chem. 2018 Oct 26;293(43):16546-16558. doi: 10.1074/jbc.RA118.004929. Epub 2018 Sep 14.
378 Selective Recognition of H3.1K36 Dimethylation/H4K16 Acetylation Facilitates the Regulation of All-trans-retinoic Acid (ATRA)-responsive Genes by Putative Chromatin Reader ZMYND8. J Biol Chem. 2016 Feb 5;291(6):2664-81. doi: 10.1074/jbc.M115.679985. Epub 2015 Dec 11.
379 Electrophysiological and pharmacological properties of the human brain type IIA Na+ channel expressed in a stable mammalian cell line. Pflugers Arch. 2001 Jan;441(4):425-33. doi: 10.1007/s004240000448.
380 Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma. Oncotarget. 2014 May 15;5(9):2355-71.
381 Bisphenol A induces DSB-ATM-p53 signaling leading to cell cycle arrest, senescence, autophagy, stress response, and estrogen release in human fetal lung fibroblasts. Arch Toxicol. 2018 Apr;92(4):1453-1469.
382 Distinct TP73-DAPK2-ATG5 pathway involvement in ATO-mediated cell death versus ATRA-mediated autophagy responses in APL. J Leukoc Biol. 2017 Dec;102(6):1357-1370. doi: 10.1189/jlb.1A0317-132R. Epub 2017 Oct 4.
383 DNA methyltransferase inhibitor 5-aza-CdR enhances the radiosensitivity of gastric cancer cells. Cancer Sci. 2009 Jan;100(1):181-8. doi: 10.1111/j.1349-7006.2008.01004.x. Epub 2008 Nov 25.
384 Neuroprotective effects of glucomoringin-isothiocyanate against H(2)O(2)-Induced cytotoxicity in neuroblastoma (SH-SY5Y) cells. Neurotoxicology. 2019 Dec;75:89-104. doi: 10.1016/j.neuro.2019.09.008. Epub 2019 Sep 12.
385 Soy isoflavones exert differential effects on androgen responsive genes in LNCaP human prostate cancer cells. J Nutr. 2007 Apr;137(4):964-72.
386 Regulation of adiponectin receptors in hepatocytes by the peroxisome proliferator-activated receptor-gamma agonist rosiglitazone. Diabetologia. 2006 Jun;49(6):1303-10. doi: 10.1007/s00125-006-0228-1. Epub 2006 Apr 12.
387 Long-term estrogen exposure promotes carcinogen bioactivation, induces persistent changes in gene expression, and enhances the tumorigenicity of MCF-7 human breast cancer cells. Toxicol Appl Pharmacol. 2009 Nov 1;240(3):355-66.
388 Progesterone regulation of implantation-related genes: new insights into the role of oestrogen. Cell Mol Life Sci. 2007 Apr;64(7-8):1009-32.
389 The genomic response of a human uterine endometrial adenocarcinoma cell line to 17alpha-ethynyl estradiol. Toxicol Sci. 2009 Jan;107(1):40-55.
390 Hypermethylation of the nel-like 1 gene is a common and early event and is associated with poor prognosis in early-stage esophageal adenocarcinoma. Oncogene. 2007 Sep 20;26(43):6332-40. doi: 10.1038/sj.onc.1210461. Epub 2007 Apr 23.
391 Transcriptome and DNA methylome dynamics during triclosan-induced cardiomyocyte differentiation toxicity. Stem Cells Int. 2018 Oct 29;2018:8608327.
392 Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. Pharmacogenomics J. 2014 Feb;14(1):35-40. doi: 10.1038/tpj.2013.3. Epub 2013 Feb 12.
393 Dose- and time-dependent transcriptional response of Ishikawa cells exposed to genistein. Toxicol Sci. 2016 May;151(1):71-87.
394 Expression profile analysis of colon cancer cells in response to sulindac or aspirin. Biochem Biophys Res Commun. 2002 Mar 29;292(2):498-512.
395 Effect of aflatoxin B(1), benzo[a]pyrene, and methapyrilene on transcriptomic and epigenetic alterations in human liver HepaRG cells. Food Chem Toxicol. 2018 Nov;121:214-223. doi: 10.1016/j.fct.2018.08.034. Epub 2018 Aug 26.
396 Epigenetic modulation of endogenous tumor suppressor expression in lung cancer xenografts suppresses tumorigenicity. Int J Cancer. 2007 Jan 1;120(1):24-31. doi: 10.1002/ijc.22073.
397 A phase I study of hydralazine to demethylate and reactivate the expression of tumor suppressor genes. BMC Cancer. 2005 Apr 29;5:44.
398 Genome-wide association for methamphetamine dependence: convergent results from 2 samples. Arch Gen Psychiatry. 2008 Mar;65(3):345-55. doi: 10.1001/archpsyc.65.3.345.
399 Intramitochondrial calcium regulation by the FHIT gene product sensitizes to apoptosis. Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12753-8. doi: 10.1073/pnas.0906484106. Epub 2009 Jul 21.
400 Association between SCN1A polymorphism and carbamazepine-resistant epilepsy. Br J Clin Pharmacol. 2008 Aug;66(2):304-7. doi: 10.1111/j.1365-2125.2008.03203.x. Epub 2008 Apr 11.
401 A transcriptomics-based in vitro assay for predicting chemical genotoxicity in vivo. Carcinogenesis. 2012 Jul;33(7):1421-9.
402 Identification of potential biomarkers of hepatitis B-induced acute liver failure using hepatic cells derived from human skin precursors. Toxicol In Vitro. 2015 Sep;29(6):1231-9. doi: 10.1016/j.tiv.2014.10.012. Epub 2014 Oct 24.
403 Suppression of cancer relapse and metastasis by inhibiting cancer stemness. Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):1839-44. doi: 10.1073/pnas.1424171112. Epub 2015 Jan 20.
404 Comparison of transcriptome expression alterations by chronic exposure to low-dose bisphenol A in different subtypes of breast cancer cells. Toxicol Appl Pharmacol. 2019 Dec 15;385:114814. doi: 10.1016/j.taap.2019.114814. Epub 2019 Nov 9.
405 CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer. J Clin Invest. 2016 Feb;126(2):639-52.
406 The genome-wide expression profile of Scrophularia ningpoensis-treated thapsigargin-stimulated U-87MG cells. Neurotoxicology. 2009 May;30(3):368-76.
407 Comprehensive analysis of transcriptomic changes induced by low and high doses of bisphenol A in HepG2 spheroids in vitro and rat liver in vivo. Environ Res. 2019 Jun;173:124-134. doi: 10.1016/j.envres.2019.03.035. Epub 2019 Mar 18.
408 10mM glucosamine prevents activation of proADAMTS5 (aggrecanase-2) in transfected cells by interference with post-translational modification of furin. Osteoarthritis Cartilage. 2010 Mar;18(3):455-63. doi: 10.1016/j.joca.2009.10.014. Epub 2009 Nov 4.
409 Coordinate up-regulation of TMEM97 and cholesterol biosynthesis genes in normal ovarian surface epithelial cells treated with progesterone: implications for pathogenesis of ovarian cancer. BMC Cancer. 2007 Dec 11;7:223.
410 Exposure to Insecticides Modifies Gene Expression and DNA Methylation in Hematopoietic Tissues In Vitro. Int J Mol Sci. 2023 Mar 26;24(7):6259. doi: 10.3390/ijms24076259.
411 Bromodomain-containing protein 4 (BRD4) regulates RNA polymerase II serine 2 phosphorylation in human CD4+ T cells. J Biol Chem. 2012 Dec 14;287(51):43137-55.
412 Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761. doi: 10.1016/j.taap.2019.114761. Epub 2019 Sep 15.
413 Quantitative phosphoproteomics reveal cellular responses from caffeine, coumarin and quercetin in treated HepG2 cells. Toxicol Appl Pharmacol. 2022 Aug 15;449:116110. doi: 10.1016/j.taap.2022.116110. Epub 2022 Jun 7.
414 A trichostatin A expression signature identified by TempO-Seq targeted whole transcriptome profiling. PLoS One. 2017 May 25;12(5):e0178302. doi: 10.1371/journal.pone.0178302. eCollection 2017.
415 Long noncoding RNA TDRG1 aggravates doxorubicin-induced cardiomyopathy by binding with miR-873-5p to upregulate PRKAR2. Environ Toxicol. 2022 Aug;37(8):2072-2083. doi: 10.1002/tox.23551. Epub 2022 May 7.